Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.

IF 3.3 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging Pub Date : 2025-06-30 DOI:10.1002/jmri.70021

Daan Bosshardt, Mitzi M van Andel, E M Schrauben, Roland R J van Kimmenade, Arthur J Scholte, Moniek G J P Cox, Daniëlle Robbers-Visser, Aeilko H Zwinderman, Barbara J M Mulder, Aart J Nederveen, Vivian de Waard, Maarten Groenink, Pim van Ooij

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引用次数: 0

Abstract

Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients.

Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS.

Study type: Prospective single-arm open-label multicenter trial.

Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of aortic root surgery (RR and native MFS), and 25 age- and sex-matched healthy controls.

Field strength/sequence: 3T, temporally resolved 3D phase contrast (4D flow MRI) and 3D mDixon sequences.

Assessment: MFS patients underwent 4D flow MRI before (baseline) and after 1 year of 500 mg daily Resveratrol treatment (follow-up). Velocity magnitude and wall shear stress (WSS) in six regions in the thoracic aorta were evaluated. Incidence maps showing abnormal hemodynamics compared to healthy controls were generated. Pulse wave velocity (PWV) was assessed in 45 subjects. The relationships between MRI parameters and annual aortic growth from the 3D mDixon scans and age were investigated.

Statistical tests: Student's paired and unpaired t-tests, Fisher's exact tests, McNemar's exact test, and Pearson correlation coefficients (r). Statistical significance was defined as p < 0.05.

Results: No significant changes in any of the hemodynamic parameters were observed: inner descending aorta WSS (Pa), native: from 1.08 ± 0.21 to 1.08 ± 0.17, p = 0.818, RR: from 1.02 ± 0.29 to 0.98 ± 0.21, p = 0.270; velocity (m/s), native: from 0.64 ± 0.10 to 0.65 ± 0.10, p = 0.359, RR: 0.68 ± 0.15, to 0.67 ± 0.12, p = 0.629; abnormally directed WSS incidence: native: from 17 (65%) to 14 (54%), p = 0.453, RR: 13 (65%) to 13 (65%), p = 1.000; PWV (m/s) native: from 7.7 ± 1.9 to 7.9 ± 1.8, p = 0.582, RR: 9.2 ± 1.6 to 8.2 ± 3.2, p = 0.184. PWV correlated with age in RR MFS patients (r = 0.59, n = 19).

Data conclusion: No significant changes in aortic hemodynamics derived from 4D flow MRI were observed after 1 year of Resveratrol treatment.

Evidence level: 1.

Technical efficacy: Stage 4.

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接受白藜芦醇治疗的马凡氏综合征患者主动脉功能的纵向4D血流MRI研究。

背景：需要新的治疗策略来减少马凡氏综合征（MFS）的主动脉事件。白藜芦醇是一种膳食补充剂，干预主动脉壁细胞代谢，可能有利于MFS患者。目的：评价白藜芦醇治疗对MFS患者血流动力学的影响。研究类型：前瞻性单臂开放标签多中心试验。人群：46例MFS患者（平均年龄36±9岁，女性23例），20例有主动脉根部手术史，26例无主动脉根部手术史（RR和原生MFS）， 25例年龄和性别匹配的健康对照。场强/序列：3T，时间分辨3D相衬（4D流MRI）和3D mDixon序列。评估：MFS患者在每日500mg白藜芦醇治疗前（基线）和1年后（随访）行4D血流MRI检查。评估胸主动脉6个区域的速度大小和壁剪切应力（WSS）。与健康对照组相比，生成了显示异常血流动力学的发生率图。对45例患者进行脉搏波速度（PWV）测定。研究了MRI参数与3D mDixon扫描的主动脉年生长和年龄之间的关系。统计检验：学生配对和非配对t检验、Fisher精确检验、McNemar精确检验和Pearson相关系数(r)。结果：各血流动力学参数均无明显变化：内降主动脉WSS (Pa)，原生值从1.08±0.21降至1.08±0.17,p = 0.818， RR从1.02±0.29降至0.98±0.21,p = 0.270；速度(米/秒),本机:从0.64±0.10,0.65±0.10,p = 0.359, RR: 0.68±0.15,0.67±0.12,p = 0.629;异常定向WSS发病率：原生：17例（65%）~ 14例（54%），p = 0.453， RR: 13例（65%）~ 13例（65%），p = 1.000；采集(m / s)本机:从7.7±1.9,7.9±1.8,p = 0.582, RR: 9.2±1.6,8.2±3.2,p = 0.184。RR MFS患者PWV与年龄相关（r = 0.59, n = 19）。数据结论：白藜芦醇治疗1年后，4D血流MRI显示主动脉血流动力学无明显变化。证据等级：1。技术功效：第4阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.