Leyre Garcia-Ruiz, Rebeca Echeverria-Chasco, Verónica Aramendía-Vidaurreta, Sergio M Solis-Barquero, Nuria Garcia-Fernandez, José María Mora-Gutiérrez, Marta Vidorreta, Gorka Bastarrika, Maria A Fernández-Seara
{"title":"场强、性别和年龄对肾脏伪连续动脉自旋标记和T1定位的影响。","authors":"Leyre Garcia-Ruiz, Rebeca Echeverria-Chasco, Verónica Aramendía-Vidaurreta, Sergio M Solis-Barquero, Nuria Garcia-Fernandez, José María Mora-Gutiérrez, Marta Vidorreta, Gorka Bastarrika, Maria A Fernández-Seara","doi":"10.1002/jmri.70009","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pseudo-continuous arterial spin labeling (PCASL) and T<sub>1</sub> mapping have been used for renal imaging at 1.5 T and 3 T. However, direct comparisons between field strengths, age, and sex are lacking.</p><p><strong>Purpose: </strong>To assess the effects of field strength, age, and sex on renal perfusion and T<sub>1</sub> values and measure reproducibility.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Sixteen healthy volunteers (eight females, age 41.8 ± 13.3 years) underwent same-day scans at 1.5 T and 3 T, repeated 1 week later.</p><p><strong>Field strength/sequence: </strong>1.5 T/3 T multi-delay PCASL with spin-echo EPI readout, inversion-recovery T<sub>1</sub> mapping, B<sub>0</sub> and B<sub>1</sub> mapping.</p><p><strong>Assessment: </strong>Multi-delay PCASL was employed to calculate renal blood flow (RBF) and arterial transit time (ATT) maps; single-delay PCASL (PLD = 1.3 s) assessed RBF and technical parameters. Cortical and medullary RBF, ATT, and T<sub>1</sub> were compared between field strengths, age, and sex groups. Reproducibility and inter-observer agreement were evaluated.</p><p><strong>Statistical tests: </strong>Shapiro-Wilk test, analysis of variance, Levene test, Box M-test, Pearson's correlation, within-subject coefficient of variation (wsCV), and intraclass correlation coefficient (ICC). P-value < 0.05 was significant.</p><p><strong>Results: </strong>3 T yielded significantly higher cortical T<sub>1</sub> (1356.02 ± 3.72 vs. 1023.29 ± 39.30 ms), and lower RBF (310.63 ± 52.72 vs. 347.65 ± 54.08 [mL/min/100 g]) than 1.5 T. Eight older (≥ 40 years) participants had significantly lower cortical RBF (1.5 T: 312.23 ± 37.59 vs. 383.06 ± 43.91 [mL/min/100 g]). Females showed significantly shorter ATT (1.5 T: 0.75 ± 0.11 s vs. 0.96 ± 0.22 s) and longer medullary T<sub>1</sub> (1.5 T: 1388.12 ± 33.68 ms vs. 1308.97 ± 28.52 ms). T<sub>1</sub> showed excellent reproducibility and inter-observer agreement (wsCV: < 2%, ICC: > 0.8). Cortical RBF was reproducible (wsCV: ~10%, ICC: > 0.7) with strong inter-observer agreement (wsCV: < 2.5%, ICC > 0.95). Medullary RBF had good inter-observer agreement (wsCV: < 4.7%, ICC: > 0.75) but poor reproducibility (wsCV: 15.78%-19.38%).</p><p><strong>Data conclusion: </strong>Cortical perfusion parameters and T<sub>1</sub> were reproducible. However, age, sex, and field strength affect the values, requiring consideration in renal imaging.</p><p><strong>Evidence level: </strong>Level 2.</p><p><strong>Technical efficacy: </strong>Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of Field Strength, Sex, and Age on Pseudo-Continuous Arterial Spin Labeling and T<sub>1</sub> Mapping in the Kidney.\",\"authors\":\"Leyre Garcia-Ruiz, Rebeca Echeverria-Chasco, Verónica Aramendía-Vidaurreta, Sergio M Solis-Barquero, Nuria Garcia-Fernandez, José María Mora-Gutiérrez, Marta Vidorreta, Gorka Bastarrika, Maria A Fernández-Seara\",\"doi\":\"10.1002/jmri.70009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Pseudo-continuous arterial spin labeling (PCASL) and T<sub>1</sub> mapping have been used for renal imaging at 1.5 T and 3 T. However, direct comparisons between field strengths, age, and sex are lacking.</p><p><strong>Purpose: </strong>To assess the effects of field strength, age, and sex on renal perfusion and T<sub>1</sub> values and measure reproducibility.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Sixteen healthy volunteers (eight females, age 41.8 ± 13.3 years) underwent same-day scans at 1.5 T and 3 T, repeated 1 week later.</p><p><strong>Field strength/sequence: </strong>1.5 T/3 T multi-delay PCASL with spin-echo EPI readout, inversion-recovery T<sub>1</sub> mapping, B<sub>0</sub> and B<sub>1</sub> mapping.</p><p><strong>Assessment: </strong>Multi-delay PCASL was employed to calculate renal blood flow (RBF) and arterial transit time (ATT) maps; single-delay PCASL (PLD = 1.3 s) assessed RBF and technical parameters. Cortical and medullary RBF, ATT, and T<sub>1</sub> were compared between field strengths, age, and sex groups. Reproducibility and inter-observer agreement were evaluated.</p><p><strong>Statistical tests: </strong>Shapiro-Wilk test, analysis of variance, Levene test, Box M-test, Pearson's correlation, within-subject coefficient of variation (wsCV), and intraclass correlation coefficient (ICC). P-value < 0.05 was significant.</p><p><strong>Results: </strong>3 T yielded significantly higher cortical T<sub>1</sub> (1356.02 ± 3.72 vs. 1023.29 ± 39.30 ms), and lower RBF (310.63 ± 52.72 vs. 347.65 ± 54.08 [mL/min/100 g]) than 1.5 T. Eight older (≥ 40 years) participants had significantly lower cortical RBF (1.5 T: 312.23 ± 37.59 vs. 383.06 ± 43.91 [mL/min/100 g]). Females showed significantly shorter ATT (1.5 T: 0.75 ± 0.11 s vs. 0.96 ± 0.22 s) and longer medullary T<sub>1</sub> (1.5 T: 1388.12 ± 33.68 ms vs. 1308.97 ± 28.52 ms). T<sub>1</sub> showed excellent reproducibility and inter-observer agreement (wsCV: < 2%, ICC: > 0.8). Cortical RBF was reproducible (wsCV: ~10%, ICC: > 0.7) with strong inter-observer agreement (wsCV: < 2.5%, ICC > 0.95). Medullary RBF had good inter-observer agreement (wsCV: < 4.7%, ICC: > 0.75) but poor reproducibility (wsCV: 15.78%-19.38%).</p><p><strong>Data conclusion: </strong>Cortical perfusion parameters and T<sub>1</sub> were reproducible. However, age, sex, and field strength affect the values, requiring consideration in renal imaging.</p><p><strong>Evidence level: </strong>Level 2.</p><p><strong>Technical efficacy: </strong>Stage 1.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.70009\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.70009","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Influence of Field Strength, Sex, and Age on Pseudo-Continuous Arterial Spin Labeling and T1 Mapping in the Kidney.
Background: Pseudo-continuous arterial spin labeling (PCASL) and T1 mapping have been used for renal imaging at 1.5 T and 3 T. However, direct comparisons between field strengths, age, and sex are lacking.
Purpose: To assess the effects of field strength, age, and sex on renal perfusion and T1 values and measure reproducibility.
Study type: Prospective.
Population: Sixteen healthy volunteers (eight females, age 41.8 ± 13.3 years) underwent same-day scans at 1.5 T and 3 T, repeated 1 week later.
Field strength/sequence: 1.5 T/3 T multi-delay PCASL with spin-echo EPI readout, inversion-recovery T1 mapping, B0 and B1 mapping.
Assessment: Multi-delay PCASL was employed to calculate renal blood flow (RBF) and arterial transit time (ATT) maps; single-delay PCASL (PLD = 1.3 s) assessed RBF and technical parameters. Cortical and medullary RBF, ATT, and T1 were compared between field strengths, age, and sex groups. Reproducibility and inter-observer agreement were evaluated.
Statistical tests: Shapiro-Wilk test, analysis of variance, Levene test, Box M-test, Pearson's correlation, within-subject coefficient of variation (wsCV), and intraclass correlation coefficient (ICC). P-value < 0.05 was significant.
Results: 3 T yielded significantly higher cortical T1 (1356.02 ± 3.72 vs. 1023.29 ± 39.30 ms), and lower RBF (310.63 ± 52.72 vs. 347.65 ± 54.08 [mL/min/100 g]) than 1.5 T. Eight older (≥ 40 years) participants had significantly lower cortical RBF (1.5 T: 312.23 ± 37.59 vs. 383.06 ± 43.91 [mL/min/100 g]). Females showed significantly shorter ATT (1.5 T: 0.75 ± 0.11 s vs. 0.96 ± 0.22 s) and longer medullary T1 (1.5 T: 1388.12 ± 33.68 ms vs. 1308.97 ± 28.52 ms). T1 showed excellent reproducibility and inter-observer agreement (wsCV: < 2%, ICC: > 0.8). Cortical RBF was reproducible (wsCV: ~10%, ICC: > 0.7) with strong inter-observer agreement (wsCV: < 2.5%, ICC > 0.95). Medullary RBF had good inter-observer agreement (wsCV: < 4.7%, ICC: > 0.75) but poor reproducibility (wsCV: 15.78%-19.38%).
Data conclusion: Cortical perfusion parameters and T1 were reproducible. However, age, sex, and field strength affect the values, requiring consideration in renal imaging.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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