Journal of Magnetic Resonance Imaging最新文献

{"title":"Discrimination Between Benign and Malignant Lesions With Restriction Spectrum Imaging MRI in an Enriched Breast Cancer Screening Cohort","authors":"Stephane Loubrie, Jingjing Zou, Ana E. Rodriguez‐Soto, Jihe Lim, Maren M.S. Andreassen, Yuwei Cheng, Summer J. Batasin, Sheida Ebrahimi, Lauren K. Fang, Christopher C. Conlin, Tyler M. Seibert, Michael E. Hahn, Vandana Dialani, Catherine J. Wei, Zahra Karimi, Joshua Kuperman, Anders M. Dale, Haydee Ojeda‐Fournier, Etta Pisano, Rebecca Rakow‐Penner","doi":"10.1002/jmri.29599","DOIUrl":"https://doi.org/10.1002/jmri.29599","url":null,"abstract":"BackgroundBreast cancer screening with dynamic contrast‐enhanced MRI (DCE‐MRI) is recommended for high‐risk women but has limitations, including variable specificity and difficulty in distinguishing cancerous (CL) and high‐risk benign lesions (HRBL) from average‐risk benign lesions (ARBL). Complementary non‐invasive imaging techniques would be useful to improve specificity.PurposeTo evaluate the performance of a previously‐developed breast‐specific diffusion‐weighted MRI (DW‐MRI) model (BS‐RSI3C) to improve discrimination between CL, HRBL, and ARBL in an enriched screening population.Study TypeProspective.SubjectsExactly 187 women, either with mammography screening recommending additional imaging (N = 49) or high‐risk individuals undergoing routine breast MRI (N = 138), before the biopsy.Field Strength/SequenceMultishell DW‐MRI echo planar imaging sequence with a reduced field of view at 3.0 T.AssessmentA total of 72 women had at least one biopsied lesion, with 89 lesions categorized into ARBL, HRBL, CL, and combined CLs and HRBLs (CHRLs). DW‐MRI data were processed to produce apparent diffusion coefficient (ADC) maps, and estimate signal contributions (C<jats:sub>1</jats:sub>, C<jats:sub>2</jats:sub>, and C<jats:sub>3</jats:sub>—restricted, hindered, and free diffusion, respectively) from the BS‐RSI3C model. Lesion regions of interest (ROIs) were delineated on DW images based on suspicious DCE‐MRI findings by two radiologists; control ROIs were drawn in the contralateral breast.Statistical TestsOne‐way ANOVA and two‐sided <jats:italic>t</jats:italic>‐tests were used to assess differences in signal contributions and ADC values among groups. <jats:italic>P</jats:italic>‐values were adjusted using the Bonferroni method for multiple testing, <jats:italic>P</jats:italic> = 0.05 was used for the significance level. Receiver operating characteristics (ROC) curves and intra‐class correlations (ICC) were also evaluated.ResultsC<jats:sub>1</jats:sub>, √C<jats:sub>1</jats:sub>C<jats:sub>2</jats:sub>, and were significantly different in HRBLs compared with ARBLs (<jats:italic>P</jats:italic>‐values &lt; 0.05). The had the highest AUC (0.821) in differentiating CHRLs from ARBLs, performing better than ADC (0.696), especially in non‐mass enhancement (0.776 vs. 0.517).Data ConclusionThis study demonstrated the BS‐RSI3C could differentiate HRBLs from ARBLs in a screening population, and separate CHRLs from ARBLs better than ADC.Level of Evidence1.Technical Efficacy Stage2.","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"206 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Discrimination Between Benign and Malignant Lesions With Restriction Spectrum Imaging MRI in a Breast Cancer Screening Cohort\".","authors":"Almir G V Bitencourt,Sunitha B Thakur","doi":"10.1002/jmri.29600","DOIUrl":"https://doi.org/10.1002/jmri.29600","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"3 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Multiparametric MRI Scoring System of the Pancreas for the Diagnosis of Chronic Pancreatitis\".","authors":"Ryan L Brunsing","doi":"10.1002/jmri.29609","DOIUrl":"https://doi.org/10.1002/jmri.29609","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial\".","authors":"Furkan Ufuk","doi":"10.1002/jmri.29613","DOIUrl":"https://doi.org/10.1002/jmri.29613","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study Between Variable Flip Angle and Modified Look-Locker Inversion Recovery for Evaluating Renal Interstitial Fibrosis.","authors":"Chenchen Hua, Yi Zhuang, Miaoyan Wang, Ting Cai, Bin Xu, Shaowei Hao, Xiangming Fang, Liang Wang, Leting Zhou","doi":"10.1002/jmri.29611","DOIUrl":"https://doi.org/10.1002/jmri.29611","url":null,"abstract":"<p><strong>Background: </strong>Variable flip angle (VFA) and modified Look-Locker inversion recovery (MOLLI) are frequently used for noninvasive evaluation of renal interstitial fibrosis (IF) in chronic kidney disease (CKD). However, controversy remains over which method is preferred.</p><p><strong>Purpose: </strong>To compare the diagnostic efficacy of VFA and MOLLI for T1 mapping in evaluating renal IF.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Fifty-one participants with CKD (CKD stage 1-5, 35 males) and 18 healthy volunteers (eight males).</p><p><strong>Field strength/sequence: </strong>3.0 T, three-dimensional gradient echo sequence for B1+ VFA, and two-dimensional gradient echo sequence for MOLLI.</p><p><strong>Assessment: </strong>Image quality was assessed on a five-point scale. Cortex and medulla T1 values (cT1 and mT1), corticomedullary T1 value difference (ΔT1, medulla - cortex), and corticomedullary T1 value ratio (ratio T1, cortex:medulla) were compared between VFA and MOLLI as well as between IF grade (0-4) based on biopsy.</p><p><strong>Statistical tests: </strong>Intraclass correlation coefficient, Bland-Altman analysis, analysis of variance, Kruskal-Wallis test, correlation analysis, and receiver operating characteristics analysis with the area under the curve (AUC). P-value <0.05 was considered significant.</p><p><strong>Results: </strong>MOLLI provided significantly better image quality compared to VFA. cT1 and mT1 values significantly differed between VFA and MOLLI (cT1-VFA: 1771.4 ± 139.4 msec vs. cT1-MOLLI: 1729.9 ± 132.1 msec; mT1-VFA: 2076.0 [interquartile range (IQR): 2045.9-2129.9] msec vs. mT1-MOLLI: 2039.2 [IQR: 1997.8-2071.6] msec). ΔT1 and ratio T1 values were not different between VFA and MOLLI (ΔT1: 300.8 ± 71.4 vs. 306.0 ± 78.4, respectively, P = 0.33 and ratio T1: 0.85 ± 0.038 vs. 0.85 ± 0.041, respectively, P = 0.064). No difference was observed between T1 variables and T1 mapping methods in diagnosing IF.</p><p><strong>Data conclusion: </strong>ΔT1 and ratio T1 were not different between VFA and MOLLI. Both VFA and MOLLI are effective for noninvasive assessment of renal IF.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Comparative Study Between Variable Flip Angle and Modified Look-Locker Inversion Recovery for Evaluating Renal Interstitial Fibrosis\".","authors":"Takeshi Yoshikawa, Takahiro Ueda, Yoshiharu Ohno","doi":"10.1002/jmri.29612","DOIUrl":"https://doi.org/10.1002/jmri.29612","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation in Small Animal fMRI.","authors":"Li-Ming Hsu, Yen-Yu Ian Shih","doi":"10.1002/jmri.29575","DOIUrl":"10.1002/jmri.29575","url":null,"abstract":"<p><p>The integration of functional magnetic resonance imaging (fMRI) with advanced neuroscience technologies in experimental small animal models offers a unique path to interrogate the causal relationships between regional brain activity and brain-wide network measures-a goal challenging to accomplish in human subjects. This review traces the historical development of the neuromodulation techniques commonly used in rodents, such as electrical deep brain stimulation, optogenetics, and chemogenetics, and focuses on their application with fMRI. We discuss their advantageousness roles in uncovering the signaling architecture within the brain and the methodological considerations necessary when conducting these experiments. By presenting several rodent-based case studies, we aim to demonstrate the potential of the multimodal neuromodulation approach in shedding light on neurovascular coupling, the neural basis of brain network functions, and their connections to behaviors. Key findings highlight the cell-type and circuit-specific modulation of brain-wide activity patterns and their behavioral correlates. We also discuss several future directions and feature the use of mediation and moderation analytical models beyond the intuitive evoked response mapping, to better leverage the rich information available in fMRI data with neuromodulation. Using fMRI alongside neuromodulation techniques provide insights into the mesoscopic (relating to the intermediate scale between single neurons and large-scale brain networks) and macroscopic fMRI measures that correlate with specific neuronal events. This integration bridges the gap between different scales of neuroscience research, facilitating the exploration and testing of novel therapeutic strategies aimed at altering network-mediated behaviors. In conclusion, the combination of fMRI with neuromodulation techniques provides crucial insights into mesoscopic and macroscopic brain dynamics, advancing our understanding of brain function in health and disease. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for “Longitudinal Multi‐Parametric Quantitative MRI Evaluation of Acute and Chronic Multiple Sclerosis Paramagnetic Rim Lesions”","authors":"Yue Zhang","doi":"10.1002/jmri.29585","DOIUrl":"https://doi.org/10.1002/jmri.29585","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"40 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Spin Labeling (ASL) MRI in Evaluating Pancreatic Blood Perfusion in Subjects With Different Glucose Tolerances","authors":"Yuling Zhang, Zhengzheng Tao, Qian Ji","doi":"10.1002/jmri.29608","DOIUrl":"https://doi.org/10.1002/jmri.29608","url":null,"abstract":"BackgroundThe pancreas plays a central role in type 2 diabetes mellitus (T2DM), and its blood flow is usually associated with insulin release demand.PurposeTo noninvasively assess pancreatic blood flow (PBF) changes and modulation in people with different glucose tolerance following a glucose challenge using ASL MRI.Study TypeProspective.SubjectsFourteen prediabetes, 22 T2DM, and 40 normal.Field Strength/SequencePseudo‐continuous ASL with a turbo gradient spin echo sequence at 3.0 T.AssessmentAll normal and subjects (diagnosed by oral glucose tolerance test) underwent ASL after fasting for at least 6 hours. The normal and prediabetes groups additionally had ASL scans at 5, 10, 15, 20, and 25 minutes following oral glucose (50 mL, 5%). PBF maps were generated from the ASL data and measured at body and tail. The ability of baseline PBF (BL‐PBF) of body, tail (BL‐PBF<jats:sub>tail</jats:sub>), and their average to determine abnormal glucose tolerance and stage was assessed.Statistical TestsANOVA, Mann–Whitney <jats:italic>U</jats:italic> test, Kruskal–Wallis H test, paired sample <jats:italic>t</jats:italic>‐test, intra‐class correlation coefficient, repeated measures ANOVA, correlation analysis, receiver operating characteristic analysis, and logistic regression analysis. A <jats:italic>P</jats:italic> value &lt;0.05 was considered significant.ResultsThere were significant differences in BL‐PBF among the three groups. The prediabetes group exhibited significantly lower PBF than the normal group at all time points; Both groups showed similar changing trends in PBF (peaking at the 15th minute and subsequently declining). The BL‐PBF<jats:sub>tail</jats:sub> had the highest diagnostic performance when evaluating abnormal glucose tolerance or stage (area under the curves = 0.800, 0.584, respectively) and was an independent risk factor for glucose tolerance status.Data ConclusionASL can noninvasively assess changes in PBF among individuals with varying glucose tolerance and in response to glucose challenge, which could be linked to insulin release demand and might help characterize changes in pancreatic endocrine function.Evidence Level2Technical EfficacyStage 1","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"43 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Middle Cerebral Artery Culprit Plaque Inflammation in Ischemic Stroke Using CAIPIRINHA‐Dixon‐TWIST Dynamic Contrast‐Enhanced Magnetic Resonance Imaging","authors":"Junxia Niu, Yuncai Ran, Rui Chen, Yan Zhang, Yong Zhang, Qi Yang, Jingliang Cheng","doi":"10.1002/jmri.29576","DOIUrl":"https://doi.org/10.1002/jmri.29576","url":null,"abstract":"BackgroundMiddle cerebral artery (MCA) plaques are a leading cause of ischemic stroke (IS). Plaque inflammation is crucial for plaque stability and urgently needs quantitative detection.PurposeTo explore the utility of Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA)‐Dixon‐Time‐resolved angiography With Interleaved Stochastic Trajectories (TWIST) (CDT) dynamic contrast‐enhanced MRI (DCE‐MRI) for evaluating MCA culprit plaque inflammation changes over stroke time and with diabetes mellitus (DM).Study TypeProspective.PopulationNinety‐four patients (51.6 ± 12.23 years, 32 females, 23 DM) with acute IS (AIS; N = 43) and non‐acute IS (non‐AIS; 14 days &lt; stroke time ≤ 3 months; N = 51).Field Strength/Sequence3‐T, CDT DCE‐MRI and three‐dimensional (3D) Sampling Perfection with Application optimized Contrast using different flip angle Evolution (3D‐SPACE) T1‐weighted imaging (T1WI).AssessmentStroke time (from initial IS symptoms to MRI) and DM were registered. For 94 MCA culprit plaques, K<jats:sup>trans</jats:sup> from CDT DCE‐MRI and enhancement ratio (ER) from 3D‐SPACE T1WI were compared between groups with and without AIS and DM.Statistical TestsShapiro–Wilk test, Bland–Altman analysis, Passing and Bablok test, independent <jats:italic>t</jats:italic>‐test, Mann–Whitney <jats:italic>U</jats:italic> test, Chi‐squared test, Fisher's exact test, receiver operating characteristics (ROC) with the area under the curve (AUC), DeLong's test, and Spearman rank correlation test with the <jats:italic>P</jats:italic>‐value significance level of 0.05.ResultsK<jats:sup>trans</jats:sup> and ER of MCA culprit plaques were significantly higher in AIS than non‐AIS patients (K<jats:sup>trans</jats:sup> = 0.098 s<jats:sup>−1</jats:sup> vs. 0.037 s<jats:sup>−1</jats:sup>; ER = 0.86 vs. 0.55). K<jats:sup>trans</jats:sup> showed better AUC for distinguishing AIS from non‐AIS patients (0.87 vs. 0.75) and stronger negative correlation with stroke time than ER (<jats:italic>r</jats:italic> = −0.60 vs. −0.34). DM patients had significantly higher K<jats:sup>trans</jats:sup> and ER than non‐DM patients in IS and AIS groups.Data ConclusionImaging by CDT DCE‐MRI may allow to quantitatively evaluate MCA culprit plaques over stroke time and DM.Evidence Level2Technical EfficacyStage 2","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"39 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}