Journal of Magnetic Resonance Imaging最新文献

{"title":"Three-Dimensional MR Elastography of Microvascular Invasion.","authors":"Armando Manduca","doi":"10.1002/jmri.29563","DOIUrl":"https://doi.org/10.1002/jmri.29563","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferumoxytol-Enhanced 5D Multiphase Steady-State Imaging Using Rotating Cartesian K-Space With Low-Rank Reconstruction for Pediatric Congenital Heart Disease.","authors":"Zixuan Zhao, Hsu-Lei Lee, Dan Ruan, Zhengyang Ming, Fei Han, Arash Bedayat, Anthony G Christodoulou, J Paul Finn, Kim-Lien Nguyen","doi":"10.1002/jmri.29565","DOIUrl":"10.1002/jmri.29565","url":null,"abstract":"<p><strong>Background: </strong>The rotating Cartesian k-space multiphase steady-state imaging with contrast (ROCK-MUSIC) pulse sequence enables acquisition of whole-heart, cardiac phase-resolved images in pediatric congenital heart disease (CHD) without reliance on the ventilator gating signal. Multidimensional reconstruction with low rank tensor (LRT) has shown promise for resolving complex cardiorespiratory motion.</p><p><strong>Purpose: </strong>To enhance ROCK-MUSIC by resolving cardiorespiratory phases using LRT reconstruction and to enable semi-automatic hyperparameter tuning by developing an image quality scoring model.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Thirty patients (45% female, age 2 days to 6.7 years) with CHD.</p><p><strong>Field strength/sequence: </strong>3-T, four-dimensional (4D) spoiled gradient recalled echo sequence.</p><p><strong>Assessment: </strong>Eigenvector-based iTerative Self-consistent Parallel Imaging Reconstruction (ESPIRiT) served as the reference comparison for LRT reconstruction. A 4-point Likert scale was used for cardiac and vascular image quality scoring based on cardiac chamber definition, lumen signal uniformity, vascular margin clarity, and motion artifact. Ejection fraction and ventricular volumes were assessed in 16 patients. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and edge sharpness were computed.</p><p><strong>Statistical tests: </strong>Intraclass correlation coefficients, Wilcoxon signed-rank test, Bland-Altman. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Relative to ESPIRiT, LRT images received significantly higher cardiac (2.81 ± 0.57 vs. 3.19 ± 0.54) and vascular (2.81 ± 0.60 vs. 3.36 ± 0.53) image quality scores. Image quality scoring with semi-automated hyperparameter tuning showed strong correlations (R² = 0.748) among image quality, SNR, and septal sharpness. Comparison of ejection fraction and volumetry derived from ESPIRiT, and LRT showed no significant systematic difference (P = 0.32).</p><p><strong>Data conclusion: </strong>Integration of low-rank reconstruction with ROCK-MUSIC acquisition may be feasible, and semi-automatic hyperparameter tuning could be effective for generating cardiorespiratory resolved images.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Spatial-Resolution and Acquisition-Efficiency Cardiac MR T1 Mapping Based on Radial bSSFP and a Low-Rank Tensor Constraint.","authors":"Juan Gao, Yiwen Gong, Yixin Emu, Zhuo Chen, Haiyang Chen, Fan Yang, Zekang Ding, Sha Hua, Wei Jin, Chenxi Hu","doi":"10.1002/jmri.29564","DOIUrl":"https://doi.org/10.1002/jmri.29564","url":null,"abstract":"<p><strong>Background: </strong>Cardiac T1 mapping is valuable for evaluating myocardial fibrosis, yet its resolution and acquisition efficiency are limited, potentially obscuring visualization of small pathologies.</p><p><strong>Purpose: </strong>To develop a technique for high-resolution cardiac T1 mapping with a less-than-100-millisecond acquisition window based on radial MOdified Look-Locker Inversion recovery (MOLLI) and a calibrationless space-contrast-coil locally low-rank tensor (SCC-LLRT) constrained reconstruction.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects/phantom: </strong>Sixteen healthy subjects (age 25 ± 3 years, 44% females) and 12 patients with suspected cardiomyopathy (age 57 ± 15 years, 42% females), NiCl2-agar phantom.</p><p><strong>Field strength/sequence: </strong>3-T, standard MOLLI, radial MOLLI, inversion-recovery spin-echo, late gadolinium enhancement.</p><p><strong>Assessment: </strong>SCC-LLRT was compared to a conventional locally low-rank (LLR) method through simulations using Normalized Root-Mean-Square Error (NRMSE) and Structural Similarity Index Measure (SSIM). Radial MOLLI was compared to standard MOLLI across phantom, healthy subjects, and patients. Three independent readers subjectively evaluated the quality of T1 maps using a 5-point scale (5 = best).</p><p><strong>Statistical tests: </strong>Paired t-test, Wilcoxon signed-rank test, intraclass correlation coefficient analysis, linear regression, Bland-Altman analysis. P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>In simulations, SCC-LLRT demonstrated a significant improvement in NRMSE and SSIM compared to LLR. In phantom, both radial MOLLI and standard MOLLI provided consistent T1 estimates across different heart rates. In healthy subjects, radial MOLLI exhibited a significantly lower mean T1 (1115 ± 39 msec vs. 1155 ± 36 msec), similar T1 SD (74 ± 14 msec vs. 67 ± 23 msec, P = 0.20), and similar T1 reproducibility (28 ± 18 msec vs. 22 ± 15 msec, P = 0.34) compared to standard MOLLI. In patients, the proposed method significantly improved the sharpness of myocardial boundaries (4.50 ± 0.65 vs. 3.25 ± 0.43), the conspicuity of papillary muscles and fine structures (4.33 ± 0.74 vs. 3.33 ± 0.47), and artifacts (4.75 ± 0.43 vs. 3.83 ± 0.55). The reconstruction time for a single slice was 5.2 hours.</p><p><strong>Data conclusion: </strong>The proposed method enables high-resolution cardiac T1 mapping with a short acquisition window and improved image quality.</p><p><strong>Evidence level: </strong>1 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.","authors":"Aaryani Tipirneni-Sajja, Utsav Shrestha, Juan Esparza, Cara E Morin, Stephan Kannengiesser, Nathan T Roberts, Johannes M Peeters, Samir D Sharma, Houchun H Hu","doi":"10.1002/jmri.29526","DOIUrl":"https://doi.org/10.1002/jmri.29526","url":null,"abstract":"<p><p>The role of MRI to estimate liver iron concentration (LIC) for identifying patients with iron overload and guiding the titration of chelation therapy is increasingly established for routine clinical practice. However, the existence of multiple MRI-based LIC quantification techniques limits standardization and widespread clinical adoption. In this article, we review the existing and widely accepted MRI-based LIC estimation methods at 1.5 T and 3 T: signal intensity ratio (SIR) and relaxometry (R2 and R2*) and discuss the basic principles, acquisition and analysis protocols, and MRI-LIC calibrations for each technique. Further, we provide an up-to-date information on MRI vendor implementations and available offline commercial and free software for each MRI-based LIC quantification approach. We also briefly review the emerging and advanced MRI techniques for LIC estimation and their current limitations for clinical use. Lastly, we discuss the implications of MRI-based LIC measurements on clinical use and decision-making in the management of patients with iron overload. Some of the key highlights from this review are as follows: 1) Both R2 and R2* can estimate accurate and reproducible LIC, when validated acquisition parameters and analysis protocols are applied, 2) Although the Ferriscan R2 method has been widely used, recent consensus and guidelines endorse R2*-MRI as the most accurate and reproducible method for LIC estimation, 3) Ongoing efforts aim to establish R2*-MRI as the standard approach for quantifying LIC, and 4) Emerging R2*-MRI techniques employ radial sampling strategies and offer improved motion compensation and broader dynamic range for LIC estimation. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Observations Regarding the Detection of Abnormal Findings Following a Cancer Screening Whole-Body MRI in Asymptomatic Subjects: The Psychological Consequences and the Role of Personality Traits Over Time\".","authors":"Ravikanth Balaji","doi":"10.1002/jmri.29527","DOIUrl":"https://doi.org/10.1002/jmri.29527","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ethanol on Brain Electrical Tissue Conductivity in Social Drinkers.","authors":"Jun Cao, Iain K Ball, Elizabeth Summerell, Peter Humburg, Tom Denson, Caroline D Rae","doi":"10.1002/jmri.29548","DOIUrl":"https://doi.org/10.1002/jmri.29548","url":null,"abstract":"<p><strong>Background: </strong>How the biophysics of electrical conductivity measures relate to brain activity is poorly understood. The sedative, ethanol, reduces metabolic activity but its impact on brain electrical conductivity is unknown.</p><p><strong>Purpose: </strong>To investigate whether ethanol reduces brain electrical tissue conductivity.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Fifty-two healthy volunteers (aged 18-37 years, 22 females, 30 males).</p><p><strong>Field strength/sequence: </strong>3 T, T1-weighted, multi-shot, turbo-field echo (TFE); 3D balanced fast-field echo (bFFE).</p><p><strong>Assessment: </strong>Brain gray and white matter tissue conductivity measured with phase-based magnetic resonance electrical properties tomography (MREPT) compared before and 20 minutes after ethanol consumption (0.7 g/kg body weight). Differential conductivity whole brain maps were generated for three subgroups: those with strong ( <math> <semantics><mrow><mo>∆</mo> <msub><mi>σ</mi> <mi>max</mi></msub> </mrow> <annotation>$$ Delta {sigma}_{mathrm{max}} $$</annotation></semantics> </math>  > 0.1 S/m; N = 33), weak (0.02 S/m ≤  <math> <semantics><mrow><mo>∆</mo> <msub><mi>σ</mi> <mi>max</mi></msub> </mrow> <annotation>$$ Delta {sigma}_{mathrm{max}} $$</annotation></semantics> </math>  ≤ 0.1 S/m; N = 9) conductivity decrease, and no significant response ( <math> <semantics><mrow><mo>∆</mo> <msub><mi>σ</mi> <mi>max</mi></msub> </mrow> <annotation>$$ Delta {sigma}_{mathrm{max}} $$</annotation></semantics> </math>  < 0.02 S/m, N = 10). Maps were compared in the strong response group where breath alcohol rose between scans, vs. those where it fell.</p><p><strong>Statistical tests: </strong>Average breath alcohol levels were compared to the differential conductivity maps using linear regression. T-maps were generated (threshold P < 0.05 and P < 0.001; minimum cluster 48 mm³). Differential conductivity maps were compared with ANOVA.</p><p><strong>Results: </strong>Whole-group analysis showed decreased conductivity that did not survive statistical thresholding. Strong responders (N = 33) showed a consistent pattern of significantly decreased conductivity ( <math> <semantics><mrow><mo>∆</mo> <msub><mi>σ</mi> <mi>max</mi></msub> </mrow> <annotation>$$ Delta {sigma}_{mathrm{max}} $$</annotation></semantics> </math>  > 0.1 S/m) in frontal/occipital and cerebellar white matter. The weak response group (N = 9) showed a similar pattern of conductivity decrease (0.02 S/m ≤  <math> <semantics><mrow><mo>∆</mo> <msub><mi>σ</mi> <mi>max</mi></msub> </mrow> <annotation>$$ Delta {sigma}_{mathrm{max}} $$</annotation></semantics> </math>  ≤ 0.1 S/m). There was no significant relationship with breath alcohol levels, alcohol use, age, ethnicity, or sex. The strong responders' regional response was different between ascending (N = 12) or descending (N = 20) alcohol during the scan.</p><p><strong>Data conclusion: </stro","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR Assessment of Acute Changes of Cerebral Perfusion, Metabolism, and Blood-Brain Barrier Permeability in Response to Aerobic Exercise.","authors":"Yizhe Hu, Wen Shi, Dengrong Jiang, Li Zhao, Hanzhang Lu, Dan Wu, Zixuan Lin","doi":"10.1002/jmri.29544","DOIUrl":"https://doi.org/10.1002/jmri.29544","url":null,"abstract":"<p><strong>Background: </strong>It remains unclear how a single bout of exercise affects brain perfusion, oxygen metabolism, and blood-brain barrier (BBB) permeability. Addressing this unresolved issue is essential to understand the acute changes in cerebral physiology induced by aerobic exercise.</p><p><strong>Purpose: </strong>To dynamically monitor the acute changes in cerebral physiology subsequent to a single aerobic exercise training session using noninvasive MRI measurements.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Twenty-three healthy participants (18-35 years, 10 females/13 males) were enrolled and divided into 10-minute exercising (N = 10) and 20-minute exercising (N = 13) groups.</p><p><strong>Field strength/sequence: </strong>3.0 T/Phase Contrast (PC) MRI (gradient echo), T₂-Relaxation-Under-Spin-Tagging (TRUST) MRI (gradient echo EPI), Water-Extraction-with-Phase-Contrast-Arterial-Spin-Tagging (WEPCAST) MRI (gradient echo EPI) and T₁-weighted magnetization-prepared-rapid-acquisition-of-gradient-echo (MPRAGE) (gradient echo).</p><p><strong>Assessment: </strong>A baseline MR measurement plus four repeated MR measurements immediately after 10 or 20 minutes moderate running exercise. MR measurements included cerebral blood flow (CBF) as measured by PC MRI, venous oxygenation (Y_v) and cerebral metabolic rate of oxygen (CMRO₂) as assessed by TRUST MRI, water extraction fraction (E), and BBB permeability-surface-area product (PS) as determined by WEPCAST MRI.</p><p><strong>Statistical tests: </strong>The time dependence of the physiological parameters was studied with a linear mixed-effect model. Additionally, pairwise t-tests comparison of the physiological parameters at each time point was conducted. A P-value of <0.05 was considered statistically significant.</p><p><strong>Results: </strong>There was an initial drop (8.22 ± 2.60%) followed by a recovery in CBF after exercise, while Y_v revealed a significant decrease (6.37 ± 0.92%), i.e., an increased oxygen extraction, and returned to baseline at later time points. CMRO₂ showed a trend of increase (5.68 ± 3.04%) and a significant interaction between time and group. In addition, E increased significantly (3.86% ± 0.89) and returned to baseline level at later time points, while PS remained elevated (13.33 ± 4.79%).</p><p><strong>Data conclusion: </strong>A single bout of moderate aerobic exercise can induce acute alterations in cerebral perfusion, metabolism, and BBB permeability.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-²H₂]Glucose Doses\".","authors":"Lijing Xin, Uzay Emir","doi":"10.1002/jmri.29546","DOIUrl":"https://doi.org/10.1002/jmri.29546","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Enabling AI-Generated Content for Gadolinium-Free Contrast-Enhanced Breast Magnetic Resonance Imaging\".","authors":"Catherine J Moran","doi":"10.1002/jmri.29535","DOIUrl":"https://doi.org/10.1002/jmri.29535","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cerebral White Matter Involvement in Amyotrophic Lateral Sclerosis Patients With Disease Progression and Cognitive Impairment by Fixel-Based Analysis and Neurite Orientation Dispersion and Density Imaging","authors":"Rui Xu MM,&nbsp;Ximing Wang MD,&nbsp;Sijia Zhu MM,&nbsp;Bin Jiang MM,&nbsp;Jiayi Wan MM,&nbsp;Jiali Ma MM,&nbsp;Yixing Yu MD,&nbsp;Liqiang Yu MD,&nbsp;Qi Fang MD,&nbsp;Chunhong Hu MD,&nbsp;Mo Zhu MD","doi":"10.1002/jmri.29557","DOIUrl":"10.1002/jmri.29557","url":null,"abstract":"<p>Group Comparison of TBSS Results (Total ALS Patients vs. Controls). TBSS Showed Differences In Neurite Density Index (NDI), Orientation Dispersion Index (ODI), Isotropic Volume Fraction (ISO), and Fractional Anisotropy (FA) Metrics between the Two Groups. The Green Color Indicates the FA Skeleton with a Threshold of 0.2. Blue Color Refers to Regions of Decreased FA, NDI, and ISO in ALS Patients Indicator Differences. Red Color Refers to the Region of Increased ODI in ALS Patients. By Xu et al. (900-908)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.29557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}