Journal of Magnetic Resonance Imaging最新文献

{"title":"Early Detection of Myocardial Involvement in Thalassemia Intermedia Patients: Multiparametric Mapping by Magnetic Resonance Imaging.","authors":"Antonella Meloni, Laura Pistoia, Davide Garamella, Alessandro Parlato, Vincenzo Positano, Paolo Ricchi, Tommaso Casini, Emanuela De Marco, Elisabetta Corigliano, Zelia Borsellino, Domenico Visceglie, Raffaele De Caterina, Alessia Pepe, Filippo Cademartiri","doi":"10.1002/jmri.29625","DOIUrl":"https://doi.org/10.1002/jmri.29625","url":null,"abstract":"<p><strong>Background: </strong>No study has assessed myocardial T1 and T2 values in patients with beta-thalassemia intermedia (β-TI).</p><p><strong>Purpose: </strong>To assess the prevalence of myocardial involvement in β-TI patients by T2* relaxometry and native T1 and T2 mapping and to determine the correlation of myocardial relaxation times with demographic and clinical parameters.</p><p><strong>Study type: </strong>Prospective matched-cohort study.</p><p><strong>Subjects: </strong>42 β-TI patients (27 females, 39.65 ± 12.32 years), enrolled in the Extension-Myocardial Iron Overload in Thalassaemia Network, and 42 age- and sex-matched healthy volunteers (27 females, 40.01 ± 11.36 years) and thalassemia major (TM) patients (27 females, 39.27 ± 11.57 years).</p><p><strong>Field strength/sequence: </strong>1.5 T/multi-echo gradient echo, modified Look-Locker inversion recovery, multi-echo fast-spin-echo, cine balanced steady-state-free precession, and late gadolinium enhancement (LGE) sequences.</p><p><strong>Assessment: </strong>Hepatic, pancreatic, and left ventricular (LV) T2* values, LV native T1 and T2 values, biventricular ejection fractions and volumes, and presence and extent of replacement myocardial fibrosis.</p><p><strong>Statistical tests: </strong>Comparisons between two groups were performed with two-sample t tests, Wilcoxon's signed rank tests, or χ² testing. Correlation analysis was performed using Pearson's or Spearman's test. P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>β-TI patients had significantly higher LV T2 values than healthy subjects (56.84 ± 4.03 vs. 52.46 ± 2.50 msec, P < 0.0001) and significantly higher LV T1 values than TM patients (1018.32 ± 48.94 vs. 966.66 ± 66.47 msec, P < 0.0001). In β-TI, female gender was associated with significantly increased LV T1 (P = 0.041) and T2 values (P < 0.0001), while splenectomy and presence of regular transfusions were associated with significantly lower LV T1 values (P = 0.014 and P = 0.001, respectively). In β-TI patients, all LV relaxation times were significantly correlated with each other (T2*-T1: P = 0.003; T2*-T2: P = 0.003; T1-T2: P < 0.0001). Two patients with a reduced LV T2* also had a reduced LV T1, while only one had a reduced LV T2. Three patients had a reduced LV T1 but a normal LV T2*; 66.7% of the patients had an increased LV T2. All LV relaxation times were significantly correlated with pancreas T2* values (T2*: P = 0.033; T1: P < 0.0001; T2: P = 0.014). No LV relaxation time was associated (P > 0.05) with hepatic iron concentration, biventricular function parameters, or LGE presence.</p><p><strong>Conclusion: </strong>The combined use of all three myocardial relaxation times has potential to improve sensitivity in the detection of early/subclinical myocardial involvement in β-Tl patients.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Deep-Learning-Based Disease Classification in Patients Undergoing Cine Cardiac MRI\".","authors":"Saber Mohammadi, Pegah Khosravi","doi":"10.1002/jmri.29621","DOIUrl":"https://doi.org/10.1002/jmri.29621","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep-Learning-Based Disease Classification in Patients Undergoing Cine Cardiac MRI.","authors":"Athira J Jacob, Teodora Chitiboi, U Joseph Schoepf, Puneet Sharma, Jonathan Aldinger, Charles Baker, Carla Lautenschlager, Tilman Emrich, Akos Varga-Szemes","doi":"10.1002/jmri.29619","DOIUrl":"https://doi.org/10.1002/jmri.29619","url":null,"abstract":"<p><strong>Background: </strong>Automated approaches may allow for fast, reproducible clinical assessment of cardiovascular diseases from MRI.</p><p><strong>Purpose: </strong>To develop an MRI-based deep learning (DL) disease classification algorithm to distinguish among normal subjects (NORM), patients with dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and ischemic heart disease (IHD).</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>A total of 1337 subjects (55% female), comprising normal subjects (N = 568), and patients with DCM (N = 151), HCM (N = 177), and IHD (N = 441).</p><p><strong>Field strength/sequence: </strong>Balanced steady-state free precession cine sequence at 1.5/3.0 T.</p><p><strong>Assessment: </strong>Bi-ventricular morphological and functional features and global and segmental left ventricular strain features were automatically extracted from short- and long-axis cine images. Variational autoencoder models were trained on the extracted features and compared against consensus disease label provided by two expert readers (13 and 14 years of experience). Adding unlabeled, normal data to the training was explored to increase specificity of NORM class.</p><p><strong>Statistical tests: </strong>Tenfold cross-validation for model development; mean, standard deviation (SD) for measurements; classification metrics: area under the curve (AUC), confusion matrix, accuracy, specificity, precision, recall; 95% confidence intervals; Mann-Whitney U test for significance.</p><p><strong>Results: </strong>AUCs of 0.952 for NORM, 0.881 for DCM, 0.908 for HCM, and 0.856 for IHD and overall accuracy of 0.778 were obtained, with specificity of 0.908 for the NORM class using both SAX and LAX features. Longitudinal strain features slightly improved classification metrics by 0.001 to 0.03 points, except for HCM-AUC. Differences in accuracy, metrics for NORM class and HCM-AUC were statistically significant. Cotraining using unlabeled data increased the specificity for the NORM class to 0.961.</p><p><strong>Data conclusion: </strong>Cardiac function features automatically extracted from cine MRI have potential to be used for disease classification, especially for normal-abnormal classification. Feature analyses showed that strain features were important for disease labeling. Cotraining using unlabeled data may help to increase specificity for normal-abnormal classification.</p><p><strong>Level of evidence: </strong>3 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Clinical Study of Nuclear Overhauser Enhancement.","authors":"Nannan Zhao, Yuanyu Shen, Dafa Shi, Yumeng Mao, Guangsong Wang, Gang Xiao, Dongyuan Xu, Gen Yan","doi":"10.1002/jmri.29623","DOIUrl":"https://doi.org/10.1002/jmri.29623","url":null,"abstract":"<p><p>Nuclear overhauser enhancement is a confounding factor arising from the in vivo application of a chemical exchange saturation transfer technique in which two nuclei in close proximity undergo dipole cross-relaxation. Several studies have shown applicability and efficacy of nuclear overhauser enhancement in observing tumors and other lesions in vivo. Thus, this effect could become an emerging molecular imaging research tool for many diseases. Moreover, nuclear overhauser enhancement has the advantages of simplicity, noninvasiveness, and high resolution and has become a major focus of current research. In this review, we summarize the principles and applications of nuclear overhauser enhancement. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging Findings From Cerebral Structure and Function in Coronary Artery Disease.","authors":"Wanbing Wang, Xinghua Zhang, Jinhao Lyu, Qi Duan, Fei Yan, Runze Li, Xinbo Xing, Yanhua Li, Xin Lou","doi":"10.1002/jmri.29624","DOIUrl":"https://doi.org/10.1002/jmri.29624","url":null,"abstract":"<p><p>An increasing number of evidence suggests that bidirectional communication between the cardiovascular system and the central nervous system (CNS), known as the heart-brain interaction, is crucial in understanding the impact of coronary artery disease (CAD) on brain health. The multifactorial role of CAD in the brain involves processes such as inflammation, oxidative stress, neuronal activity, neuroendocrine imbalances, and reduced cerebral perfusion, leading to various cerebral abnormalities. The mechanisms underlying the relationship between CAD and brain injury are complex and involve parallel pathways in the CNS, endocrine system, and immune system. Although the exact mechanisms remain partially understood, neuroimaging techniques offer valuable insights into subtle cerebral abnormalities in CAD patients. Neuroimaging techniques, including assessment of neural function, brain metabolism, white matter microstructure, and brain volume, provide information on the evolving nature of CAD-related cerebral abnormalities over time. This review provides an overview of the pathophysiological mechanisms of CAD in the heart-brain interaction and summarizes recent neuroimaging studies utilizing multiparametric techniques to investigate brain abnormalities associated with CAD. The application of advanced neuroimaging, particularly functional, diffusion, and perfusion advanced techniques, offers high resolution, multiparametric capabilities, and high contrast, thereby allowing for the early detection of changes in brain structure and function, facilitating further exploration of the intricate relationship between CAD and brain health. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Diagnosis of Major Depressive Disorder Based on Individualized Brain Functional and Structural Connectivity\".","authors":"Ismail Koubiyr, Thomas Tourdias","doi":"10.1002/jmri.29618","DOIUrl":"https://doi.org/10.1002/jmri.29618","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Major Depressive Disorder Based on Individualized Brain Functional and Structural Connectivity.","authors":"Yuting Guo, Tongpeng Chu, Qinghe Li, Qun Gai, Heng Ma, Yinghong Shi, Kaili Che, Fanghui Dong, Feng Zhao, Danni Chen, Wanying Jing, Xiaojun Shen, Gangqiang Hou, Xicheng Song, Ning Mao, Peiyuan Wang","doi":"10.1002/jmri.29617","DOIUrl":"https://doi.org/10.1002/jmri.29617","url":null,"abstract":"<p><strong>Background: </strong>Traditional neuroimaging studies have primarily emphasized analysis at the group level, often neglecting the specificity at the individual level. Recently, there has been a growing interest in individual differences in brain connectivity. Investigating individual-specific connectivity is important for understanding the mechanisms of major depressive disorder (MDD) and the variations among individuals.</p><p><strong>Purpose: </strong>To integrate individualized functional connectivity and structural connectivity with machine learning techniques to distinguish people with MDD and healthy controls (HCs).</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>A total of 182 patients with MDD and 157 HCs and a verification cohort including 54 patients and 46 HCs.</p><p><strong>Field strength/sequence: </strong>3.0 T/T1-weighted imaging, resting-state functional MRI with echo-planar sequence, and diffusion tensor imaging with single-shot spin echo.</p><p><strong>Assessment: </strong>Functional and structural brain networks from rs-fMRI and DTI data were constructed, respectively. Based on these networks, individualized functional connectivity (IFC) and individualized structural connectivity (ISC) were extracted using common orthogonal basis extraction (COBE). Subsequently, multimodal canonical correlation analysis combined with joint independent component analysis (mCCA + jICA) was conducted to fusion analysis to identify the joint and unique independent components (ICs) across multiple modes. These ICs were utilized to generate features, and a support vector machine (SVM) model was implemented for the classification of MDD.</p><p><strong>Statistical tests: </strong>The differences in individualized connectivity between patients and controls were compared using two-sample t test, with a significance threshold set at P < 0.05. The established model was tested and evaluated using the receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>The classification performance of the constructed individualized connectivity feature model after multisequence fusion increased from 72.2% to 90.3%. Furthermore, the prediction model showed significant predictive power for assessing the severity of depression in patients with MDD (r = 0.544).</p><p><strong>Data conclusion: </strong>The integration of IFC and ISC through multisequence fusion enhances our capacity to identify MDD, highlighting the advantages of the individualized approach and underscoring its significance in MDD research.</p><p><strong>Level of evidence: </strong>1 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative MRI for Monitoring Metabolic Dysfunction-Associated Steatotic Liver Disease: A Test-Retest Repeatability Study.","authors":"Cayden Beyer, Anneli Andersson, Elizabeth Shumbayawonda, Naim Alkouri, Ami Banerjee, Prashant Pandya, Mukesh Harisinghani, Kathleen Corey, Andrea Dennis, Michele Pansini","doi":"10.1002/jmri.29610","DOIUrl":"https://doi.org/10.1002/jmri.29610","url":null,"abstract":"<p><strong>Background: </strong>Quantitative magnetic resonance imaging metrics iron-corrected T1 (cT1) and liver fat from proton density fat-fraction (PDFF) are both commonly used as noninvasive biomarkers for metabolic dysfunction-associated steatohepatitis (MASH); however, their repeatability in this population has rarely been characterized.</p><p><strong>Purpose: </strong>To quantify the variability of cT1 and liver fat fraction from PDFF in patients with biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) and MASH.</p><p><strong>Study type: </strong>Prospective, single center.</p><p><strong>Population: </strong>Twenty-one participants (female = 11, mean age 53 ± 24 years) with biopsy-confirmed MASLD, including 6 with MASH and fibrosis ≥2.</p><p><strong>Field strength/sequence: </strong>3 T; T1 and T2* mapping for the generation of cT1 (shMOLLI: CardioMaps and 2D MDE, T1map-FIESTA and LMS MOST: StarMap, 2D Multi-Echo FSPGR) and magnitude-only PDFF sequence for liver fat quantification (LMS IDEAL: StarMap, 2D Multi-Echo FSPGR).</p><p><strong>Assessment: </strong>T1 mapping and PDFF scans were performed twice on the same day for all participants (N = 21), with an additional scan 2-4 weeks later for MASH patients with fibrosis ≥2 (N = 6). Whole liver segmentation masks were generated semi-automatically and average pixel counts within these masks were used for the calculation of cT1 and liver fat fraction.</p><p><strong>Statistical tests: </strong>Bland-Altman analysis for repeatability coefficient (RC) and 95% limits of agreement (LOA) and intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>Same-day RC was 32.1 msec (95% LOA: -36.6 to 24.2 msec) for cT1 and 0.6% (95% LOA: -0.5% to 0.7%) for liver fat fraction; the ICCs were 0.98 (0.96-0.99) and 1.0, respectively. Short-term RC was 65.2 msec (95% LOA: -63.8 to 76.5 msec) for cT1 and 2.6% (95% LOA: -2.8% to 3.1%) for liver fat fraction.</p><p><strong>Data conclusion: </strong>In participants with MASLD and MASH, cT1 and liver fat fraction measurements show excellent test-retest repeatability, supporting their use in monitoring MASLD and MASH.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Visual Pathway White Matter Degeneration in Primary Open-Angle Glaucoma Using Multiple MRI Morphology and Diffusion Metrics.","authors":"Linying Guo, Yin Wang, Fengjuan Gao, Fei Duan, Yuzhe Wang, Jingfeng Cheng, Dandan Shen, Jianfeng Luo, Lingjie Wu, Rifeng Jiang, Xinghuai Sun, Zuohua Tang","doi":"10.1002/jmri.29616","DOIUrl":"https://doi.org/10.1002/jmri.29616","url":null,"abstract":"<p><strong>Background: </strong>Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness, is associated with neurodegeneration in the visual pathway, but the underlying pathophysiology remains incompletely resolved.</p><p><strong>Purpose: </strong>To characterize macro- and microstructural white matter abnormalities in optic tract (OT) and optic radiation (OR) of POAG.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Populations: </strong>A total of 34 POAG patients (21 males, 13 females) and 25 healthy controls (HCs) (16 males, nine females).</p><p><strong>Field strength/sequence: </strong>3 T; multiband spin-echo echo planar diffusion spectrum imaging (DSI).</p><p><strong>Assessment: </strong>We compared multiple morphology metrics, including volume, area, length, and shape metrics, as well as diffusion metrics such as diffusion tensor imaging (fractional anisotropy [FA], mean diffusivity, radial diffusivity, and axial diffusivity), mean apparent propagator (mean squared displacement, q-space inverse variance, return-to-origin probability, return-to-axis probabilities [RTAP] and return-to-plane probabilities, non-Gaussianity, perpendicular non-Gaussianity, parallel non-Gaussianity), and neurite orientation dispersion and density imaging (intracellular volume fraction, orientation dispersion index [ODI], and isotropic volume fraction of the OT and OR).</p><p><strong>Statistical tests: </strong>Statistical comparisons and classifications employed linear mixed model and logistic regression. Diagnostic performance was assessed using area under the receiver operating characteristic curve (AUC). P-value <0.05 was statistically significant.</p><p><strong>Results: </strong>Morphology analysis in POAG revealed a lower span in the OR (29.43 ± 2.30 vs. 30.59 ± 2.01, 3.8%) and OT (19.73 ± 2.21 vs. 20.68 ± 1.37, 4.6%), and a higher curl (3.03 ± 0.22 vs. 2.90 ± 0.16, 4.5%) in OT. Diffusion metrics revealed lower mean FA (OR: 0.328 ± 0.03 vs. 0.340 ± 0.018, 3.5%; OT: 0.255 ± 0.022 vs. 0.268 ± 0.018, 4.9%) and lower mean RTAP (OR: 5.919 ± 0.529 vs. 6.216 ± 0.489, 4.8%; OT: 4.089 ± 0.402 vs. 4.280 ± 0.353, 4.5%), with higher mean ODI in the OT (0.448 ± 0.029 vs. 0.433 ± 0.025, 3.5%). Combined models, incorporating these MRI metrics, effectively discriminated POAG from HCs, achieving AUCs of 0.84 for OR and 0.83 for OT.</p><p><strong>Data conclusions: </strong>DSI-derived morphology and diffusion metrics demonstrated macro- and micro abnormalities in the visual pathway, providing insights into POAG-related neurodegeneration.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glymphatic System in Preterm Neonates: Developmental Insights Following Birth Asphyxia.","authors":"Shiwei Lin, Xiaoshan Lin, Qunjun Liang, Shengli Chen, Yanyu Zhang, Ying Li, Tianfa Dong, Yingwei Qiu","doi":"10.1002/jmri.29615","DOIUrl":"https://doi.org/10.1002/jmri.29615","url":null,"abstract":"<p><strong>Background: </strong>Birth asphyxia (BA) and germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) are common clinical events in preterm neonates. However, their effects on the glymphatic system (GS) development in preterm neonates remain arcane.</p><p><strong>Purpose: </strong>To evaluate the developmental trajectory of the GS, and to investigate the effects of BA and GMH-IVH on GS function in preterm neonates.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Two independent datasets, prospectively acquired internal dataset (including 99 preterm neonates, 40 female, mean [standard deviation] gestational age (GA) at birth, 29.95 [2.63] weeks) and the developing Human Connectome Project (dHCP) dataset (including 81 preterm neonates, 29 female, median [interquartile range] GA at birth, 32.71 [4.28] weeks).</p><p><strong>Field strength/sequence: </strong>3.0 T MRI and diffusion-weighted spin-echo planar imaging sequence.</p><p><strong>Assessment: </strong>The diffusion-weighted images were preprocessed in volumetric space using the FMRIB Software Library and diffusion along the perivascular space (DTI-ALPS) index was accessed to evaluate GS function.</p><p><strong>Statistical tests: </strong>Two sample t tests, one-way analysis of variance followed by least-significant difference (LSD) post hoc analysis, chi-squared tests, and Pearson's correlation analysis. Significance level: P < 0.05.</p><p><strong>Results: </strong>In prospectively acquired internal dataset, preterm neonates with BA exhibited a significant lower DTI-ALPS index than those without BA (0.98 ± 0.08 vs. 1.08 ± 0.07, T = -5.89); however, GMH-IVH did not exert significant influences on the DTI-ALPS index (P = 0.83 and 0.27). The DTI-ALPS index increased significantly at postmenstrual age ranging from 25 to 34 weeks (r = 0.38) and then plateaued after 34 weeks (P = 0.35), which we also observed in the dHCP dataset.</p><p><strong>Data conclusion: </strong>BA rather than GMH-IVH serves as the major influencing factor in the development of GS in preterm neonates. Moreover, as GS development follows a nonlinear trajectory, we recommend close monitoring of GS development in preterm neonates with a GA less than 34 weeks.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}