Feras Qawasmi, Maria Segev, Tamer Sobah, Larisa Gorenstein, Gadi Abebe-Campino, Chen Hoffmann, Michal Yalon, Dalit Modan-Moses, Shai Shrot
{"title":"Imaging Assessment of the Pituitary Gland and Long-Term Endocrinological Abnormalities in Pediatric Brain Cancer Survivors.","authors":"Feras Qawasmi, Maria Segev, Tamer Sobah, Larisa Gorenstein, Gadi Abebe-Campino, Chen Hoffmann, Michal Yalon, Dalit Modan-Moses, Shai Shrot","doi":"10.1002/jmri.29674","DOIUrl":"https://doi.org/10.1002/jmri.29674","url":null,"abstract":"<p><strong>Background: </strong>Pediatric brain cancer survivors often experience hypothalamic-pituitary dysfunction due to cranial irradiation and chemotherapy. While hormone deficiencies have been studied, the changes in pituitary size and shape on long-term MRI and their relationship to endocrine dysfunction remain under-explored.</p><p><strong>Purpose: </strong>To evaluate pituitary gland height, volume, and shape in relation to long-term endocrine abnormalities in pediatric brain tumor survivors.</p><p><strong>Study type: </strong>Retrospective cohort study.</p><p><strong>Population: </strong>A total of 56 pediatric brain tumor survivors (50% male) with an average follow-up of 10.8 ± 1.6 years; 44.6% underwent radiotherapy, and 48% were treated with chemotherapy. One-third of the cohort experienced at least one pituitary hormone deficiency.</p><p><strong>Field strength/sequence: </strong>3 T, including volumetric 1 mm sagittal post-contrast T1 images.</p><p><strong>Assessment: </strong>Pituitary height, volume, and shape (concave, horizontal, convex) were measured. Endocrine abnormalities were diagnosed through routine serum hormone testing.</p><p><strong>Statistical tests: </strong>The t test, chi-square test, and Pearson test with significance at P < 0.05 were used. Receiver-operating characteristic (ROC) analysis assessed the association of imaging parameters and pituitary dysfunction.</p><p><strong>Results: </strong>Radiation and chemotherapy treatment were significantly associated with pituitary hormone deficiencies. There were significant differences in pituitary height and volume in patients with pituitary hormone deficiencies compared with normal pituitary function (4.0 ± 1.3 vs. 5.5 ± 1.5 mm, and 354.2 ± 198.0 vs. 568.3 ± 184.4 mm<sup>3</sup>, respectively). There was a significant association between radiation therapy and pituitary gland shape, with 60.0% of patients who received radiation therapy exhibiting a pituitary shape categorized as concave, 32.0% as horizontal, and 8.0% as convex, compared to 9.7%, 74.2%, and 16.1%, respectively. ROC analysis for association with pituitary hormone deficiency was 0.81, 0.8, and 0.74 for pituitary height, volume, and shape, respectively.</p><p><strong>Data conclusion: </strong>Cranial irradiation and chemotherapy in pediatric brain tumors are associated with endocrine dysfunction, with decreased pituitary height, volume, and concave shape in long-term MRI surveillance are associated with such late endocrine dysfunction.</p><p><strong>Level of evidence: </strong>4 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Age-Related Microstructure Changes in Thigh Skeletal Muscle Based on Neurite Orientation Dispersion and Density Imaging.","authors":"Yiou Wang, Yiqiong Yang, Ziru Qiu, Yanjun Chen, Xinru Zhang, Qianyi Qiu, Yi Yang, Qinglin Xie, Xinyuan Zhang, Xiaodong Zhang","doi":"10.1002/jmri.29675","DOIUrl":"https://doi.org/10.1002/jmri.29675","url":null,"abstract":"<p><strong>Background: </strong>Neurite orientation dispersion and density imaging (NODDI) could offer information about the morphological properties of tissue. Diffusion microstructure imaging has been widely used, but the applicability of NODDI in skeletal muscle imaging remains to be explored.</p><p><strong>Purpose: </strong>To evaluate microstructure parameters variations in skeletal muscle as indicators of age-related changes.</p><p><strong>Study type: </strong>Prospective, cross-sectional.</p><p><strong>Population: </strong>A total of 108 asymptomatic volunteers, divided into three age groups: 20-39 years (N = 34), 40-59 years (N = 40), and over 60 years (N = 34).</p><p><strong>Field strength/sequence: </strong>3-T, three-dimensional (3D) gradient echo sequence.</p><p><strong>Assessment: </strong>T1-weighted imaging, T2-weighted imaging with spectral adiabatic inversion recovery, and NODDI were used to image the thigh skeletal muscles. Four thigh skeletal muscle groups were analyzed, including bilateral thigh quadriceps femoris and hamstrings. The microstructure parameters included orientation dispersion index (ODI), intra-myofibrillar water volume fraction (V-intra), free-water fraction (V-csf), fractional anisotropy (FA), and mean diffusivity (MD). These parameters were quantified using NODDI images and compared among different age, body mass index (BMI), and skeletal muscle index (SMI) subgroups.</p><p><strong>Statistical tests: </strong>Segmentation measurement reliability was assessed using a two-way mixed intraclass correlation coefficient (ICC). Shapiro-Wilk tests were used to assess data distribution. Kruskal-Wallis and Mann-Whitney U tests were used to compare ODI, V-intra, V-csf, FA, and MD values among different age, BMI, and SMI subgroups. The Spearman correlation coefficient was utilized to assess the strength of the correlation between the age and microstructure parameters, as well as between age and SMI. Additionally, Bonferroni post hoc tests were conducted on microstructure parameters that exhibited significant differences across various age groups. A P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Significant differences in ODI, V-csf, FA, and MD values were observed among age, BMI, and SMI subgroups.</p><p><strong>Data conclusion: </strong>NODDI may be used to reveal information about microstructure integrity and local physiological changes of thigh skeletal muscle fibers in relation to age.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neil J Stewart, Nara S Higano, Lena Wucherpfennig, Simon M F Triphan, Amy Simmons, Laurie J Smith, Mark O Wielpütz, Jason C Woods, Jim M Wild
{"title":"Pulmonary MRI in Newborns and Children.","authors":"Neil J Stewart, Nara S Higano, Lena Wucherpfennig, Simon M F Triphan, Amy Simmons, Laurie J Smith, Mark O Wielpütz, Jason C Woods, Jim M Wild","doi":"10.1002/jmri.29669","DOIUrl":"https://doi.org/10.1002/jmri.29669","url":null,"abstract":"<p><p>Lung MRI is an important tool in the assessment and monitoring of pediatric and neonatal lung disorders. MRI can provide both similar and complementary image contrast to computed tomography for imaging the lung macrostructure, and beyond this, a number of techniques have been developed for imaging the key functions of the lungs, namely ventilation, perfusion, and gas exchange, through the use of free-breathing proton and hyperpolarized gas MRI. Here, we review the state-of-the-art in MRI methods that have found utility in pediatric and neonatal lung imaging, the structural and physiological information that can be gleaned from such images, and strategies that have been developed to deal with respiratory (and cardiac) motion, and other technological challenges. The application of lung MRI in neonatal and pediatric lung conditions, in particular bronchopulmonary dysplasia, cystic fibrosis, and asthma, is reviewed, highlighting our collective experiences in the clinical translation of these methods and technology, and the key current and future potential avenues for clinical utility of this methodology. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Dai, Chun Lian, Zhuo Zhang, Jing Gao, Fan Lin, Ziyin Li, Qi Wang, Tongpeng Chu, Dilinuer Aishanjiang, Meiying Chen, Ximing Wang, Guanxun Cheng, Rong Huang, Jianjun Dong, Haicheng Zhang, Ning Mao
{"title":"Development and Validation of a Deep Learning System to Differentiate HER2-Zero, HER2-Low, and HER2-Positive Breast Cancer Based on Dynamic Contrast-Enhanced MRI.","authors":"Yi Dai, Chun Lian, Zhuo Zhang, Jing Gao, Fan Lin, Ziyin Li, Qi Wang, Tongpeng Chu, Dilinuer Aishanjiang, Meiying Chen, Ximing Wang, Guanxun Cheng, Rong Huang, Jianjun Dong, Haicheng Zhang, Ning Mao","doi":"10.1002/jmri.29670","DOIUrl":"https://doi.org/10.1002/jmri.29670","url":null,"abstract":"<p><strong>Background: </strong>Previous studies explored MRI-based radiomic features for differentiating between human epidermal growth factor receptor 2 (HER2)-zero, HER2-low, and HER2-positive breast cancer, but deep learning's effectiveness is uncertain.</p><p><strong>Purpose: </strong>This study aims to develop and validate a deep learning system using dynamic contrast-enhanced MRI (DCE-MRI) for automated tumor segmentation and classification of HER2-zero, HER2-low, and HER2-positive statuses.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>One thousand two hundred ninety-four breast cancer patients from three centers who underwent DCE-MRI before surgery were included in the study (52 ± 11 years, 811/204/279 for training/internal testing/external testing).</p><p><strong>Field strength/sequence: </strong>3 T scanners, using T1-weighted 3D fast spoiled gradient-echo sequence, T1-weighted 3D enhanced fast gradient-echo sequence and T1-weighted turbo field echo sequence.</p><p><strong>Assessment: </strong>An automated model segmented tumors utilizing DCE-MRI data, followed by a deep learning models (ResNetGN) trained to classify HER2 statuses. Three models were developed to distinguish HER2-zero, HER2-low, and HER2-positive from their respective non-HER2 categories.</p><p><strong>Statistical tests: </strong>Dice similarity coefficient (DSC) was used to evaluate the segmentation performance of the model. Evaluation of the model performances for HER2 statuses involved receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC), accuracy, sensitivity, and specificity. The P-values <0.05 were considered statistically significant.</p><p><strong>Results: </strong>The automatic segmentation network achieved DSC values of 0.85 to 0.90 compared to the manual segmentation across different sets. The deep learning models using ResNetGN achieved AUCs of 0.782, 0.776, and 0.768 in differentiating HER2-zero from others in the training, internal test, and external test sets, respectively. Similarly, AUCs of 0.820, 0.813, and 0.787 were achieved for HER2-low vs. others, and 0.792, 0.745, and 0.781 for HER2-positive vs. others, respectively.</p><p><strong>Data conclusion: </strong>The proposed DCE-MRI-based deep learning system may have the potential to preoperatively distinct HER2 expressions of breast cancers with therapeutic implications.</p><p><strong>Evidence level: </strong>4 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Prenatal MR Diagnosis of Total Anomalous Pulmonary Venous Connection and Related Brain Growth Changes\".","authors":"Aviad Rabinowich, Livia Kapusta","doi":"10.1002/jmri.29673","DOIUrl":"https://doi.org/10.1002/jmri.29673","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing-Ya Ren, Chang-An Chen, Ming Zhu, Ke Liu, Li-Jun Chen, Su-Zhen Dong
{"title":"Prenatal MR Diagnosis of Total Anomalous Pulmonary Venous Connection and Related Brain Growth Changes.","authors":"Jing-Ya Ren, Chang-An Chen, Ming Zhu, Ke Liu, Li-Jun Chen, Su-Zhen Dong","doi":"10.1002/jmri.29671","DOIUrl":"https://doi.org/10.1002/jmri.29671","url":null,"abstract":"<p><strong>Background: </strong>Prenatal diagnosis of total anomalous pulmonary venous connection (TAPVC) is challenging, and little is known about how it affects brain development.</p><p><strong>Purpose: </strong>To evaluate the utility of fetal MRI to diagnose TAPVC and related brain growth changes.</p><p><strong>Study type: </strong>Retrospective case-control study.</p><p><strong>Population: </strong>Twenty-one fetuses (23.0 to 30.8 weeks, mean 26.4 weeks) with pre-natal MRI diagnosis of TAPVC. Post-natal images and surgery were available in 18 fetuses. Brain volumes in TAPVC fetuses were compared with age and sex matched 100 cases of normal controls and 38 fetuses with tetralogy of Fallot (TOF).</p><p><strong>Sequence: </strong>Single shot turbo spin echo sequence for evaluating fetal brain, and steady-state free precession (SSFP) sequence for evaluating fetal cardiovascular structures at 1.5 T.</p><p><strong>Assessment: </strong>TAPVC type was determined by visualizing the drainage of the common pulmonary vein and dilated coronary sinus: supracardiac, intracardiac and infracardiac. The fetal pulmonary edema was evaluated, and fetal brain volumes were measured using automatic segmentation.</p><p><strong>Statistical tests: </strong>One-way analysis of variance and post hoc least square difference tests to evaluate differences in variables between TAPVC, TOF and control groups. A P value <0.05 was considered significant.</p><p><strong>Results: </strong>Of the 21 cases of TAPVC, 10 (47.6%) were identified as supracardiac, 8 (38.1%) as intracardiac, and 3 (14.3%) as infracardiac. Eighteen cases were confirmed by postnatal imaging and surgery; the remaining three cases had no confirmation. Six cases were associated with other cardiovascular abnormalities. Key MRI features of fetal TAPVC included a dilated coronary sinus and vertical vein. Fetal pulmonary edema was seen in six cases. Compared to controls, TAPVC fetuses had lower cerebellum and brainstem volumes and higher e-CSF, while had larger subcortical brain tissue, cerebellum, brainstem, e-CSF, and intracranial cavity volumes than those of TOF cases.</p><p><strong>Data conclusion: </strong>Fetal MRI may be a useful modality for evaluating fetal TAPVC and altered brain development.</p><p><strong>Evidence level: </strong>3 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Parhiala, Juha Knaapila, Ivan Jambor, Janne Verho, Kari Syvänen, Hannu Aronen, Peter Boström, Otto Ettala
{"title":"Long-Term Risk of Clinically Significant Prostate Cancer in Biopsy-Negative Patients With Baseline Biparametric Prostate MRI.","authors":"Laura Parhiala, Juha Knaapila, Ivan Jambor, Janne Verho, Kari Syvänen, Hannu Aronen, Peter Boström, Otto Ettala","doi":"10.1002/jmri.29668","DOIUrl":"https://doi.org/10.1002/jmri.29668","url":null,"abstract":"<p><strong>Background: </strong>The long-term prevalence of clinically significant prostate cancer (csPCa) in patients with initial negative prostate biopsy is unknown.</p><p><strong>Purpose: </strong>To investigate the rate of csPCa of men with initial negative biopsy.</p><p><strong>Study type: </strong>Retrospective analysis of prospectively collected data.</p><p><strong>Population: </strong>A total of 197 men (mean age 63 years [SD ±6.98, range 29-79]) without csPCa on initial biopsy and available baseline biparametric prostate MRI (bpMRI).</p><p><strong>Field strength/sequence: </strong>3.0 T, turbo spin-echo T2-weighted (axial and sagittal) and three sets of diffusion-weighted imaging using single-shot spin-echo planar imaging (5 b-values 0-500 seconds/mm<sup>2</sup>; 2 b-values 0 and 1500 seconds/mm<sup>2</sup>, and 2 b-values 0 and 2000 seconds/mm<sup>2</sup>).</p><p><strong>Assessment: </strong>BpMRI was read using Prostate Imaging Reporting Data System (PI-RADS) v2.1. Systematic or targeted biopsy results served as reference standard.</p><p><strong>Statistical tests: </strong>Continuous variables were compared using Kruskal-Wallis rank sum test. Categorical variables were compared using either Fisher's exact test or Pearson's chi-square test. Uni- and multivariate regression odds ratios (95% confidence interval) were used to study factors affecting csPCa being diagnosed during follow-up. Time to diagnosis of csPCa is calculated using the Kaplan-Meier method.</p><p><strong>Results: </strong>Of 197 men, 74 (38%), 57 (29%), and 66 (34%) presented with PI-RADS 1-2, 3, and 4-5 findings in the baseline bpMRI. During the median follow-up of 52 months, 8.1%, 5.3%, and 18.2% of these men were diagnosed with csPCa, respectively. Baseline PI-RADS finding was the only factor that associated with csPCa found during the follow-up.</p><p><strong>Data conclusion: </strong>Baseline bpMRI with PI-RADS scores 1-3 and initial biopsies negative of csPCa had low rate of csPCa during follow-up, which supports more conservative follow-up for them but further research with longer follow-up is warranted.</p><p><strong>Level of evidence: </strong>3 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Chai, Jun Sun, Zhizheng Zhuo, Ren Wei, Xiaolu Xu, Yunyun Duan, Decai Tian, Yutong Bai, Ningnannan Zhang, Haiqing Li, Yuxin Li, Yongmei Li, Fuqing Zhou, Jun Xu, James H Cole, Frederik Barkhof, Jianguo Zhang, Huaguang Zheng, Yaou Liu
{"title":"Estimated Brain Age in Healthy Aging and Across Multiple Neurological Disorders.","authors":"Li Chai, Jun Sun, Zhizheng Zhuo, Ren Wei, Xiaolu Xu, Yunyun Duan, Decai Tian, Yutong Bai, Ningnannan Zhang, Haiqing Li, Yuxin Li, Yongmei Li, Fuqing Zhou, Jun Xu, James H Cole, Frederik Barkhof, Jianguo Zhang, Huaguang Zheng, Yaou Liu","doi":"10.1002/jmri.29667","DOIUrl":"https://doi.org/10.1002/jmri.29667","url":null,"abstract":"<p><strong>Background: </strong>The brain aging in the general population and patients with neurological disorders is not well understood.</p><p><strong>Purpose: </strong>To characterize brain aging in the above conditions and its clinical relevance.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>A total of 2913 healthy controls (HC), with 1395 females; 331 multiple sclerosis (MS); 189 neuromyelitis optica spectrum disorder (NMOSD); 239 Alzheimer's disease (AD); 244 Parkinson's disease (PD); and 338 cerebral small vessel disease (cSVD).</p><p><strong>Field strength/sequence: </strong>3.0 T/Three-dimensional (3D) T1-weighted images.</p><p><strong>Assessment: </strong>The brain age was estimated by our previously developed model, using a 3D convolutional neural network trained on 9794 3D T1-weighted images of healthy individuals. Brain age gap (BAG), the difference between chronological age and estimated brain age, was calculated to represent accelerated and resilient brain conditions. We compared MRI metrics between individuals with accelerated (BAG ≥ 5 years) and resilient brain age (BAG ≤ -5 years) in HC, and correlated BAG with MRI metrics, and cognitive and physical measures across neurological disorders.</p><p><strong>Statistical tests: </strong>Student's t test, Wilcoxon test, chi-square test or Fisher's exact test, and correlation analysis. P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>In HC, individuals with accelerated brain age exhibited significantly higher white matter hyperintensity (WMH) and lower regional brain volumes than those with resilient brain age. BAG was significantly higher in MS (10.30 ± 12.6 years), NMOSD (2.96 ± 7.8 years), AD (6.50 ± 6.6 years), PD (4.24 ± 4.8 years), and cSVD (3.24 ± 5.9 years) compared to HC. Increased BAG was significantly associated with regional brain atrophy, WMH burden, and cognitive impairment across neurological disorders. Increased BAG was significantly correlated with physical disability in MS (r = 0.17).</p><p><strong>Data conclusion: </strong>Healthy individuals with accelerated brain age show high WMH burden and regional volume reduction. Neurological disorders exhibit distinct accelerated brain aging, correlated with impaired cognitive and physical function.</p><p><strong>Level of evidence: </strong>4 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominika Suchá, Anneloes E Bohte, Pim van Ooij, Tim Leiner, Eric M Schrauben, Heynric B Grotenhuis
{"title":"Fetal Cardiovascular Magnetic Resonance: History, Current Status, and Future Directions.","authors":"Dominika Suchá, Anneloes E Bohte, Pim van Ooij, Tim Leiner, Eric M Schrauben, Heynric B Grotenhuis","doi":"10.1002/jmri.29664","DOIUrl":"https://doi.org/10.1002/jmri.29664","url":null,"abstract":"<p><p>Fetal cardiovascular magnetic resonance imaging (MRI) has emerged as a complementary modality for prenatal imaging in suspected congenital heart disease. Ongoing technical improvements extend the potential clinical value of fetal cardiovascular MRI. Ascertaining equivocal prenatal diagnostics obtained with ultrasonography allows for appropriate parental counseling and planning of postnatal surgery. This work summarizes current acquisition techniques and clinical applications of fetal cardiovascular MRI in the prenatal diagnosis and follow-up of fetuses with congenital heart disease. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Assessment the Impact of IDH Mutation Status on MRI Assessments of White Matter Integrity in Glioma Patients: Insights From Peak Width of Skeletonized Mean Diffusivity and Free Water Metrics\".","authors":"Steven Benitez, Seena Dehkharghani","doi":"10.1002/jmri.29651","DOIUrl":"https://doi.org/10.1002/jmri.29651","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}