Journal of Magnetic Resonance Imaging最新文献

{"title":"Editorial for \"High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age\".","authors":"Masaaki Hori, Kei Nakahara, Masahiro Kobayashi","doi":"10.1002/jmri.29745","DOIUrl":"10.1002/jmri.29745","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"749-750"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR Fingerprinting Predicts Gait Improvement After Lumbar Cerebrospinal Fluid Drainage for Normal Pressure Hydrocephalus.","authors":"R Sky Jones, Jacqueline Chen, Doksu Moon, Mathias Nittka, Tiffany Ejikeme, Dan Ma, Mark Griswold, Sean Nagel, Stephen E Jones","doi":"10.1002/jmri.29788","DOIUrl":"10.1002/jmri.29788","url":null,"abstract":"<p><strong>Background: </strong>Normal pressure hydrocephalus (NPH) results in gait disturbance, but clinical response to extended lumbar drainage (ELD) of cerebrospinal fluid varies. Noninvasive predictors of response are needed.</p><p><strong>Purpose: </strong>To determine whether MR fingerprinting (MRF) findings have potential as a quantifiable biomarker for predicting clinical response to ELD in patients with NPH.</p><p><strong>Study type: </strong>Prospective cohort.</p><p><strong>Population: </strong>Twenty individuals with NPH (mean age 77.7 years; 11 male sex).</p><p><strong>Field strength/sequence: </strong>3T; 2D T₁,T₁/T₂ MRF, 3D T₁.</p><p><strong>Assessment: </strong>Patients with NPH referred for ELD between August 2020 and February 2023 were recruited and underwent brain MRI and 10 m walking test before and after ELD. Clinical response was defined as improvement in the walking test plus a positive neurosurgical assessment. Quantitative T ₁ and T ₂ values were obtained using MRF. Whole-brain T ₁ and T ₂ times were obtained for cerebral white matter (WM) and gray matter (GM). Brain volumetry was derived using a 3DT₁-weighted sequence.</p><p><strong>Statistical tests: </strong>Linear discriminants to predict responder status were derived from logistic regression against T ₁ and T ₂ times; supplementary discriminants from visual inspection (manual delineation) were created as well. Fisher's exact test was applied to resulting contingency tables with significance at p < 0.05. Receiver operating characteristic curves were generated to assess predictors.</p><p><strong>Results: </strong>There were 11 responders and 9 nonresponders. Pretreatment MRF demonstrated an ability to distinguish responders from nonresponders (areas under the curve: WM T ₁, 0.83 ± 0.21; GM T ₁, 0.76 ± 0.23; WM T ₂, 0.81 ± 0.22; GM T ₂, 0.81 ± 0.22). Via logistic regression, GM measures significantly predicted responder status (OR = 14.0 [1.54, 130]) but WM measures did not (p = 0.37). Visual inspection yielded significance for GM (OR incalculable due to zero-valued contingency cell) and WM (OR = 18.7 [1.56, 222]).</p><p><strong>Data conclusion: </strong>Elevated whole-brain T ₁ and T ₂ relaxation times may serve as a noninvasive predictive biomarker of response to ELD in patients with NPH.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"880-889"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Stroke Mechanism Subtypes and Prognosis in Patients With Symptomatic Intracranial Atherosclerosis Based on Multiparametric MRI\".","authors":"Shuang Xia, Huiying Wang","doi":"10.1002/jmri.29831","DOIUrl":"10.1002/jmri.29831","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"928-929"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke Mechanism Subtypes and Prognosis in Patients With Symptomatic Intracranial Atherosclerosis Based on Multiparametric MRI.","authors":"Wenqiao Zheng, Hua Wei, Fan Bai, Yichun Qu, Zhichang Fan, Yan Li, Bin Wang, Yongfang Wang, Le Wang, Xiaochun Wang","doi":"10.1002/jmri.29813","DOIUrl":"10.1002/jmri.29813","url":null,"abstract":"<p><strong>Background: </strong>Different stroke mechanisms present with distinct imaging characteristics and prognosis. Multiparametric MRI can characterize these variations and may contribute to stroke secondary prevention.</p><p><strong>Purpose: </strong>To investigate the stroke mechanism subtypes and prognosis in patients with symptomatic intracranial atherosclerosis using multiparametric MRI.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Two hundred and seventeen ischemic stroke patients (147 males; age 55.5 ± 11.7 years) with intracranial atherosclerosis.</p><p><strong>Field strength/sequence: </strong>3-T, dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI); High-resolution vessel wall imaging (HR-VWI): three-dimensional (3D) T1-weighted Sampling Perfection with Application optimized Contrast using different flip angle Evolution (SPACE) and contrast-enhanced T1-SPACE.</p><p><strong>Assessment: </strong>All patients underwent multiparametric MRI within 7 days of stroke symptom onset. The stroke mechanisms included branch occlusive disease (BOD), artery-to-artery embolism, hypoperfusion, and mixed mechanisms. The following imaging characteristics were assessed by three radiologists independently. HR-VWI plaque characteristics included plaque area, lipid area, lipid ratio, occlusive thrombus, degree of stenosis, plaque burden, enhancement ratio, remodeling index, and intraplaque hemorrhage (IPH). The mean transit time-Alberta Stroke Program Early Computed Tomography score (MTT-ASPECTS) based on DSC-PWI was used to evaluate perfusion impairment. During a median follow-up period of 15 months, the correlation between different stroke mechanisms and prognosis was analyzed.</p><p><strong>Statistical tests: </strong>Chi-squared or Fisher's exact, Kruskal-Wallis H-tests, multivariate logistic regression, and Kaplan-Meier curves. All p-values were corrected by Bonferroni correction, and p-values < 0.05 were considered statistically significant.</p><p><strong>Results: </strong>Mixed mechanism was the most common subtype (32.7%). Significant differences were observed in perfusion impairment, degree of stenosis, plaque burden, enhancement ratio, IPH, and remodeling among stroke mechanisms. Of these characteristics, MTT-ASPECTS (odds ratio [OR] 0.70, 95% CI 0.562-0.863) and IPH (OR 2.30, 95% CI 1.042-5.051) were significantly associated with non-BOD mechanisms. Hypoperfusion mechanism was associated with a higher risk of stroke recurrence during a median follow-up of 15 months (hazard ratio 3.97, 95% CI 1.43-11.03).</p><p><strong>Data conclusion: </strong>Multiparametric MRI may reveal differences in imaging characteristics among stroke mechanisms. Hypoperfusion may be associated with an increased risk of stroke recurrence.</p><p><strong>Evidence level: </strong>3. Technical Efficacy: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"917-927"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Prostate Cancer Risk Stratification and Scan Tailoring Using Deep Learning on Abbreviated Prostate MRI\".","authors":"Felipe Sahb Furtado","doi":"10.1002/jmri.29806","DOIUrl":"10.1002/jmri.29806","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"867-868"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"MRI Assessment of Lung Water Density in Individuals Previously Infected With COVID-19: A Cross-Sectional Study\".","authors":"Laura C Saunders, A A Roger Thompson, Jim M Wild","doi":"10.1002/jmri.29821","DOIUrl":"10.1002/jmri.29821","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"779-780"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitat Radiomics Based on Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessing Axillary Lymph Node Burden in Clinical T1-T2 Stage Breast Cancer: A Multicenter and Interpretable Study.","authors":"Siyi Chen, Yue Zhang, Yuqi Su, Jie Tian, Yongxin Chen, Wenjie Tang, Yaheng Fan, Chen Jin, Yangcheng He, Yongzhou Xu, Hong Hu, Yuan Guo, Junping Li","doi":"10.1002/jmri.29796","DOIUrl":"10.1002/jmri.29796","url":null,"abstract":"<p><strong>Background: </strong>Axillary lymph node burden(ALNB) is a critical factor in determining treatment strategies for clinical T₁-T₂ (cT₁-T₂) stage breast cancer. However, as ALNB assessment relies on invasive procedures, exploring non-invasive methods is essential.</p><p><strong>Purpose: </strong>To develop and validate a habitat radiomics model for assessing ALNB in cT₁-T₂ breast cancer, incorporating radiogenomic data to improve interpretability.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>468 patients with cT₁-T₂ stage breast cancer from two institutions and The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA)-Breast Invasive Carcinoma (BRCA) were included. The cohort was divided into training (n = 173), internal validation (n = 58), external validation (n = 130), and TCGA-BRCA sets (n = 107). Patients were categorized into high nodal burden (HNB; > 3 positive lymph nodes) and non-HNB (≤ 3 positive lymph nodes) groups.</p><p><strong>Field strength/sequence: </strong>1.5-T MRI and 3.0-T MRI, and three-dimensional dynamic contrast-enhanced T1-weighted gradient-echo sequences.</p><p><strong>Assessment: </strong>Two logistic regression models were developed using habitat-based and clinical features. Model performance was evaluated using the AUC. SHapley Additive exPlanations (SHAP) analysis was employed to identify key features. Radiogenomic analysis, including gene set enrichment and drug sensitivity assessments, was conducted using transcriptomic data from the TCGA-BRCA set.</p><p><strong>Statistical tests: </strong>Pearson correlation, Mann-Whitney U, genetic algorithm, logistic regression, AUC analysis, delong test, and SHAP analysis. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The Habitat model outperformed the Clinical model (AUCs: 0.840-0.932 vs. 0.558-0.673). The SHAP analysis was used to rank feature importance, with subregion 3 showing the highest average SHAP value. Radiogenomic analysis indicated upregulation of the KEGG ribosome pathway in the HNB group and identified differential drug sensitivity profiles among risk groups.</p><p><strong>Data conclusion: </strong>The Habitat model has the potential to assess ALNB in cT₁-T₂ breast cancer and assist radiologists in axillary diagnosis, which may help reduce the need for unnecessary ALN dissection.</p><p><strong>Evidence level: </strong>3. Technical Efficacy: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"751-764"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age.","authors":"Zhiyi Hu, Dengrong Jiang, Jennifer Shepard, Yuto Uchida, Kenichi Oishi, Wen Shi, Peiying Liu, Doris Lin, Vivek Yedavalli, Aylin Tekes, William Christopher Golden, Hanzhang Lu","doi":"10.1002/jmri.29740","DOIUrl":"10.1002/jmri.29740","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Perfusion imaging of the brain has important clinical applications in detecting neurological abnormalities in neonates. However, such tools have not been available to date. Although arterial-spin-labeling (ASL) MRI is a powerful noninvasive tool to measure perfusion, its application in neonates has encountered obstacles related to low signal-to-noise ratio (SNR), large-vessel contaminations, and lack of technical development studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To systematically develop and optimize ASL perfusion MRI in healthy neonates under 1 week of age.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study type: &lt;/strong&gt;Prospective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects: &lt;/strong&gt;Thirty-two healthy term neonates (19 female; postnatal age 1.9 ± 0.7 days).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Field strength/sequence: &lt;/strong&gt;3.0 T; T&lt;sub&gt;2&lt;/sub&gt; -weighted half-Fourier single-shot turbo-spin-echo (HASTE) imaging, single-delay and multi-delay 3D gradient-and-spin-echo (GRASE) large-vessel-suppression pseudo-continuous ASL (LVS-pCASL).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Assessment: &lt;/strong&gt;Three studies were conducted. First, an LVS-pCASL MRI sequence was developed to suppress large-vessel spurious signals in neonatal pCASL. Second, multiple post-labeling delays (PLDs) LVS-pCASL were employed to simultaneously estimate normative cerebral blood flow (CBF) and arterial transit time (ATT) in neonates. Third, an enhanced background-suppression (BS) scheme was developed to increase the SNR of neonatal pCASL.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical tests: &lt;/strong&gt;Repeated measure analysis-of-variance, paired t-test, spatial intraclass-correlation-coefficient (ICC), and voxel-wise coefficient-of-variation (CoV). P-value &lt;0.05 was considered significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;LVS-pCASL reduced spurious ASL signals, making the CBF images more homogenous and significantly reducing the temporal variation of CBF measurements by 58.0% when compared to the standard pCASL. Multi-PLD ASL yielded ATT and CBF maps showing a longer ATT and lower CBF in the white matter relative to the gray matter. The highest CBF was observed in basal ganglia and thalamus (10.4 ± 1.9 mL/100 g/min). Enhanced BS resulted in significantly higher test-retest reproducibility (ICC = 0.90 ± 0.04, CoV = 8.4 ± 1.2%) when compared to regular BS (ICC = 0.59 ± 0.12, CoV = 23.6 ± 3.8%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data conclusion: &lt;/strong&gt;We devised an ASL method that can generate whole-brain CBF images in 4 minutes with a test-retest image ICC of 0.9. This technique holds potential for studying neonatal brain diseases involving perfusion abnormalities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;MR imaging of cerebral blood flow in neonates remains a challenge due to low blood flow rates and confounding factors from large blood vessels. This study systematically developed an advanced MRI technique to enhance the reliability of perfusion measurements in neonates. The proposed method reduced signal artifacts from large blood vessels and improved the signal-to-no","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"737-748"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Altered Brain Functional Networks in Patients With Breast Cancer After Different Cycles of Neoadjuvant Chemotherapy\".","authors":"Hernan Jara, Chad W Farris","doi":"10.1002/jmri.29773","DOIUrl":"10.1002/jmri.29773","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"915-916"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Improved and Automated Detection of Papillary Muscle Infarction Using Joint Bright- and Black-Blood Late Gadolinium Enhancement MRI\".","authors":"Robert J Holtackers, Akos Varga-Szemes, Martijn W Smulders","doi":"10.1002/jmri.29794","DOIUrl":"10.1002/jmri.29794","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"840-841"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}