利用超极化MRI进行代谢和分子成像的技术和策略。

IF 3.5 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Alixander S Khan, Christoffer Laustsen
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引用次数: 0

摘要

传统的磁共振成像(MRI)由于低热核自旋极化,对非质子核的直接代谢和分子成像的灵敏度有限。超极化(HP)技术将核自旋极化提高了几个数量级,克服了这一限制,使生物化学和生理学的体内研究成为可能。越来越多的文献表明,HP技术为各种临床应用提供了有用的代谢和功能信息。本文详细介绍了超极化MRI的完整工作流程,从用于产生超极化样品的方法和可用探针的范围到最大化信号所需的特定成像采集和数据分析策略,最后介绍了其主要的临床应用。证据等级:5。技术功效:第3阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.

Conventional Magnetic Resonance Imaging (MRI) offers limited sensitivity for direct metabolic and molecular imaging using non-proton nuclei due to low thermal nuclear spin polarization. Hyperpolarization (HP) technologies increase nuclear spin polarization by several orders of magnitude, overcoming this limitation to enable in vivo studies of biochemistry and physiology. A growing body of literature has shown the value in HP technologies offering metabolic and functional information useful for a variety of clinical applications. This review details the complete workflow of hyperpolarized MRI, from the methodologies used to produce hyperpolarized samples and the range of available probes to the specific imaging acquisition and data analysis strategies required to maximize the signal, and finally, its major clinical applications. EVIDENCE LEVEL: 5. TECHNICAL EFFICACY: Stage 3.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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