国际肿瘤学杂志最新文献

{"title":"Research progress on exosome-derived non-coding RNAs in liquid biopsy of hepatocelluar carcinoma","authors":"Fang Zhang","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.06.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.06.014","url":null,"abstract":"Exosomes contain ample non-coding RNAs, which mainly function as regulating gene expre-ssion and play key roles in the occurrence and development of hepatocellular carcinoma. Exosomal non-coding RNAs are expected to become a new biopsy marker for hepatocellular carcinoma, providing a new means for early diagnosis and early treatment of hepatocellular carcinoma.Although the clinical application of exosomal non-coding RNAs is still insufficient at present, exosomal non-coding RNAs will play an increasingly important role in the diagnosis, personalized treatment and prognosis evaluation of hepatocellular carcinoma with the deepening of research. \u0000 \u0000 \u0000Key words: \u0000Liver neoplasms; Liquid biopsy; Exosomes; Non-coding RNA","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"8 1","pages":"378-381"},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78462382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of gene mutations and targeted treatment of brain metastases in breast cancer","authors":"Z. Yi, F. Ma","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.06.008","url":null,"abstract":"Brain metastasis (BM) is considered one of the major causes of mortality in breast cancer patients. BM develops more frequently in triple-negative breast cancer and human epidermal growth factor receptor 2 (HER2)-positive breast cancers, while the incidence of BM in hormone receptor positive is much lower. Mutations and expression of BM of breast cancer are differ from their primary tumors. Importantly, some therapeutic actionable mutations can be present in the BM while not in the primary tumors. Current targeted therapeutics in BM of breast cancers are limited, and drugs used have proven effects on the primary tumors but lack specificity for the BM. The identification of genomic and expressional alterations specific to BM are crucial to the development of BM specific targeted therapies. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Brain metastasis; Mutation; Targeted therapy","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"46 1","pages":"354-357"},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73775102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"微小RNA-424-5p调控OTX1对结直肠癌细胞增殖、迁移和侵袭的影响","authors":"余昆, 王伟雅, 蔡昕怡, 程先硕, 赵笑枫, 别雅琴, 李强","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.06.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.06.001","url":null,"abstract":"Objective \u0000To investigate the correlation of the expression of microRNA-424-5p (miR-424-5p) and orthodenticle homeobox 1 (OTX1) gene in colorectal cancer (CRC) tissue, and the effects of miR-424-5p on the proliferation, migration and invasion of CRC cells HCT116. \u0000 \u0000 \u0000Methods \u0000A total of 60 patients with CRC were collected from June 2017 to June 2018 in Department of Colorectal Surgery of Third Affiliated Hospital of Kunming Medical University. Real time quantitative PCR (RT-qPCR) was used to detect the expression of miR-424-5p and OTX1 mRNA in 60 cases of CRC tissues, para-carcinoma tissues and CRC cell lines. The correlation between the expression of miR-424-5p and OTX1 gene was further analyzed. miR-NC (miR-NC group) and miR-424-5p-mimic (miR-424-5p-mimic group) were transfected into HCT116 cells. CCK-8 assay, scratch assay and Transwell assay were used to detect the effects of miR-424-5p on the proliferation, migration and invasion of HCT116 cells. The effect of miR-424-5p on the expression of OTX1 protein was detected by Western blotting. The luciferase report assay was used to detect the influence of miR-424-5p on the luciferase activity of OTX1-3′UTR vector. \u0000 \u0000 \u0000Results \u0000The relative expressions of OTX1 mRNA in CRC tissues and para-carcinoma tissues were 1.049±0.446 and 0.639±0.178 (t=-6.583, P<0.001); and the relative expression of miR-424-5p in CRC tissues and para-carcinoma tissues were 0.865±0.261 and 1.329±0.387 (t=7.705, P<0.001), with statistically significant differences. Negative correlation was found between the expression of miR-424-5p and OTX1 mRNA in CRC tissues (r=-0.439, P=0.015). The absorbance values of HCT116 cells transfected with miR-424-5p-mimic were 0.813±0.064, 0.960±0.098, 1.287±0.192 on 72, 96 and 120 hours respectively, and those of HCT116 cells transfected with miR-NC were 1.163±0.158, 1.645±0.117 and 2.043±0.236. The proliferation ability of miR-424-5p-mimic group was lower than that of miR-NC group and the differences between the two groups were statistically significant (t=3.538, P=0.024; t=7.778, P=0.001; t=4.257, P=0.013). The scratch assay showed that the migration of HCT116 cells in miR-424-5p-mimic group was inhibited as compared with miR-NC group. The numbers of cells permeating septum of miR-NC and miR-424-5p-mimic group were 177.104±17.834 and 35.667±13.634, and the difference was statistically significant (t=15.246, P<0.001). The relative expressions of OTX1 protein in miR-NC and miR-424-5p-mimic group were 0.862±0.121 and 0.342±0.103 respectively, and the difference was statistically significant (t=16.286, P<0.001). Luciferase report assay showed that the luciferase activities of wt-OTX1-3′UTR and mut-OTX1-3′UTR vector were 0.305±0.095 and 0.898±0.080 after over expression of miR-424-5p, and the difference was statistically significant (P<0.001). \u0000 \u0000 \u0000Conclusion \u0000The expressions of miR-424-5p and OTX1 mRNA are negatively correlated in CRC tissue. miR-424-5p can inhibit the proliferation, migration a","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"280 1","pages":"321-326"},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89066515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances of homeobox gene MEOX1 in tumors","authors":"Yuan Zhang","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.005","url":null,"abstract":"As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differenti-ation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors. \u0000 \u0000 \u0000Key words: \u0000Genes, homeobox; Neoplasms; MEOX1","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"21 1","pages":"278-280"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86328309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippo signaling pathway and colorectal cancer","authors":"Sijia Gu, G. Sun, Dawei Qiao, Yi Zhong, G. Kong, P. Bu","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.010","url":null,"abstract":"Hippo signaling pathway plays a significant role in the development of colorectal cancer, and acts as an important regulatory pathway which regulates cell proliferation and cell differentiation. Multiple proteins and genes in Hippo signaling pathway, especially the downstream YAP protein, play important roles in the occurrence, metastasis, drug resistance and recurrence of colorectal cancer. YAP and other related genes can be used as targeted markers for predicting drug resistance to colorectal cancer. Hippo signaling pathway gene network can be used as targeted therapy or combination therapy, thus providing new ideas for the treatment of colorectal cancer. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Molecular targeted therapy; Hippo signaling pathway; YAP protein","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"35 5 1","pages":"299-302"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75684436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Nivolumab in the treatment of advanced non-small cell lung cancer","authors":"Dongqi Liu, Runze Chen, Yuhan Liu, Huan Zhou","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.009","url":null,"abstract":"Lung cancer has the highest morbidity and mortality among malignant tumors in our country. The treatment researches related to non-small cell lung cancer (NSCLC) such as targeted therapy and immunotherapy are the research hotspots in recent years. Nivolumab is the first programmed death-1 (PD-1) inhibitor which is allowed to enter clinical trials, and it is also the first approved drug for tumor immunotherapy in China. In June 2018, Nivolumab injection was marketed in China, and it was used in the second-line treatment for the patients with advanced NSCLC, opened up a new era of the lung cancer treatment in our country. Review the clinical research related to the Nivolumab and NSCLC, summarizing usage, dosage, adverse reactions, will provide a help for clinical application, bring more benefits for patients at the same time. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, non-small-cell lung; Immunotherapy; Nivolumab","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"34 1","pages":"295-298"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85503369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy prediction and molecular mechanism of thyroid hormone levels and multi-target TKI therapy for renal cell carcinoma and hepatocellular carcinoma","authors":"Yueqin Sun, Aimin Li, Yue Luo, Zheng-Xiang Song, Xue-Wei Zhuang, Guanqi Dai","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.011","url":null,"abstract":"Hypothyroidism is a common adverse reaction in clinical multi-target tyrosine kinase inhibitor (TKI) and may be used as a predictor of efficacy of TKI drugs. Studies show that hypothyroidism is significantly associated with good prognosis in patients with renal cell carcinoma treated with multi-target TKI, which may be related to inhibition of vascular endothelial growth factor receptor pathway, potential off-target effects and inhibition of cell proliferation. Whereas in the patients with hepatocellular carcinoma who received multi-target TKI therapy, hypothyroidism is an indicator of poor prognosis, which is related to the T3/TR pathway regulating liver cancer growth and invasion. The predictive function and mechanism of thyroid hormone levels in different tumor patients receiving multi-target TKI drugs are different, and further research is still needed. \u0000 \u0000 \u0000Key words: \u0000Thyroid hormones; Neoplasms; Prognosis; Tyrosine kinase inhibitors","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"27 1","pages":"303-306"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91209450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-tumor mechanism of lactoferrin","authors":"Xiao-mei Mo, Pengfei Qin, N. Zhao, Meixing Yan","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.007","url":null,"abstract":"Alterations of the lactoferrin gene are associated with an increased incidence of tumor, however, the exact mechanisms involved in the anti-tumor activity of lactoferrin are still unclear. Several studies suggest that lactoferrin can affect the initiation and development of tumors via different mechanisms such as damaging cell membranes, inducing apoptosis, blocking cell cycle, regulating cellular immune response and inhibiting angiogenesis in different cancer cell lines. Further study about the mechanism can provide new ideas for clinical prevention and treatment of tumors. \u0000 \u0000 \u0000Key words: \u0000Lactoferrin; Neoplasms; Apoptosis","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"75 1","pages":"285-288"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86163894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and future challenges of HPV preventive vaccine of cervical cancer","authors":"An-jie Li, Fang Wei","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.012","url":null,"abstract":"Human papillomavirus (HPV) vaccine is approved by the the U. S. Food and Drug Administration in 2006 for female cancer prevention. There are currently three types of prophylactic HPV vaccines, and its application in developed countries can significantly reduce HPV infection rates and cervical lesion rates. In developing countries, HPV vaccination rates are low due to lack of knowledge of cervical cancer and funds. At the same time, concerns about vaccine safety have led to a reduction in vaccination rates in developed countries. Countries are facing the challenge of increasing vaccination rates. \u0000 \u0000 \u0000Key words: \u0000Papillomaviridae; Uterine cervical neoplasms; Papillomavirus vaccines; Primary prevention","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"96 1","pages":"307-310"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82225244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1/TGF-β双功能抑制剂融合蛋白M7824研究进展","authors":"胡梦雪，许斌，于金明，宋启斌, Xu Bin Yu Jinming Song Qibin Hu Mengxue","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.006","url":null,"abstract":"With the development of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors, the second generation of combined immunosuppressive agents emerge as the times require. As a bifunctional anti-PD-L1/transforming growth factor-β (TGF-β) fusion protein, M7824 can antagonize PD-L1 pathway and trap TGF-β at the same time, which can effectively enhance the immune response and reduce the occurrence of immune escape and drug resistance. The drug has achieved remarkable results in many preclinical studies, however, the indications, safety and efficacy still need to be confirmed by large-scale clinical research data. \u0000 \u0000 \u0000Key words: \u0000Recombinant fusion proteins; Transforming growth factor β; PD-L1; M7824","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"27 1","pages":"281-284"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90168718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}