Research progress on exosome-derived non-coding RNAs in liquid biopsy of hepatocelluar carcinoma

Abstract

Exosomes contain ample non-coding RNAs, which mainly function as regulating gene expre-ssion and play key roles in the occurrence and development of hepatocellular carcinoma. Exosomal non-coding RNAs are expected to become a new biopsy marker for hepatocellular carcinoma, providing a new means for early diagnosis and early treatment of hepatocellular carcinoma.Although the clinical application of exosomal non-coding RNAs is still insufficient at present, exosomal non-coding RNAs will play an increasingly important role in the diagnosis, personalized treatment and prognosis evaluation of hepatocellular carcinoma with the deepening of research. Key words: Liver neoplasms; Liquid biopsy; Exosomes; Non-coding RNA