{"title":"肿瘤同源盒基因MEOX1的研究进展","authors":"Yuan Zhang","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.005","DOIUrl":null,"url":null,"abstract":"As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differenti-ation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors. \n \n \nKey words: \nGenes, homeobox; Neoplasms; MEOX1","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"21 1","pages":"278-280"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances of homeobox gene MEOX1 in tumors\",\"authors\":\"Yuan Zhang\",\"doi\":\"10.3760/CMA.J.ISSN.1673-422X.2019.05.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differenti-ation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors. \\n \\n \\nKey words: \\nGenes, homeobox; Neoplasms; MEOX1\",\"PeriodicalId\":16120,\"journal\":{\"name\":\"国际肿瘤学杂志\",\"volume\":\"21 1\",\"pages\":\"278-280\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际肿瘤学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际肿瘤学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differenti-ation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors.
Key words:
Genes, homeobox; Neoplasms; MEOX1
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