{"title":"乳铁蛋白的抗肿瘤机制","authors":"Xiao-mei Mo, Pengfei Qin, N. Zhao, Meixing Yan","doi":"10.3760/CMA.J.ISSN.1673-422X.2019.05.007","DOIUrl":null,"url":null,"abstract":"Alterations of the lactoferrin gene are associated with an increased incidence of tumor, however, the exact mechanisms involved in the anti-tumor activity of lactoferrin are still unclear. Several studies suggest that lactoferrin can affect the initiation and development of tumors via different mechanisms such as damaging cell membranes, inducing apoptosis, blocking cell cycle, regulating cellular immune response and inhibiting angiogenesis in different cancer cell lines. Further study about the mechanism can provide new ideas for clinical prevention and treatment of tumors. \n \n \nKey words: \nLactoferrin; Neoplasms; Apoptosis","PeriodicalId":16120,"journal":{"name":"国际肿瘤学杂志","volume":"75 1","pages":"285-288"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-tumor mechanism of lactoferrin\",\"authors\":\"Xiao-mei Mo, Pengfei Qin, N. Zhao, Meixing Yan\",\"doi\":\"10.3760/CMA.J.ISSN.1673-422X.2019.05.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alterations of the lactoferrin gene are associated with an increased incidence of tumor, however, the exact mechanisms involved in the anti-tumor activity of lactoferrin are still unclear. Several studies suggest that lactoferrin can affect the initiation and development of tumors via different mechanisms such as damaging cell membranes, inducing apoptosis, blocking cell cycle, regulating cellular immune response and inhibiting angiogenesis in different cancer cell lines. Further study about the mechanism can provide new ideas for clinical prevention and treatment of tumors. \\n \\n \\nKey words: \\nLactoferrin; Neoplasms; Apoptosis\",\"PeriodicalId\":16120,\"journal\":{\"name\":\"国际肿瘤学杂志\",\"volume\":\"75 1\",\"pages\":\"285-288\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际肿瘤学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际肿瘤学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-422X.2019.05.007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Alterations of the lactoferrin gene are associated with an increased incidence of tumor, however, the exact mechanisms involved in the anti-tumor activity of lactoferrin are still unclear. Several studies suggest that lactoferrin can affect the initiation and development of tumors via different mechanisms such as damaging cell membranes, inducing apoptosis, blocking cell cycle, regulating cellular immune response and inhibiting angiogenesis in different cancer cell lines. Further study about the mechanism can provide new ideas for clinical prevention and treatment of tumors.
Key words:
Lactoferrin; Neoplasms; Apoptosis
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