Hippo信号通路与结直肠癌

国际肿瘤学杂志 Pub Date : 2019-05-08 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.05.010

Sijia Gu, G. Sun, Dawei Qiao, Yi Zhong, G. Kong, P. Bu

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引用次数: 0

摘要

Hippo信号通路在结直肠癌的发生发展中起着重要作用，是调控细胞增殖和细胞分化的重要调控通路。Hippo信号通路中的多种蛋白和基因，尤其是下游的YAP蛋白，在结直肠癌的发生、转移、耐药和复发中发挥着重要作用。YAP等相关基因可作为预测结直肠癌耐药的靶向标记物。Hippo信号通路基因网络可作为靶向治疗或联合治疗，从而为结直肠癌的治疗提供新的思路。关键词:结直肠肿瘤;分子靶向治疗;Hippo信号通路;YAP蛋白质

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Hippo signaling pathway and colorectal cancer

Hippo signaling pathway plays a significant role in the development of colorectal cancer, and acts as an important regulatory pathway which regulates cell proliferation and cell differentiation. Multiple proteins and genes in Hippo signaling pathway, especially the downstream YAP protein, play important roles in the occurrence, metastasis, drug resistance and recurrence of colorectal cancer. YAP and other related genes can be used as targeted markers for predicting drug resistance to colorectal cancer. Hippo signaling pathway gene network can be used as targeted therapy or combination therapy, thus providing new ideas for the treatment of colorectal cancer. Key words: Colorectal neoplasms; Molecular targeted therapy; Hippo signaling pathway; YAP protein

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国际肿瘤学杂志

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12123

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