Journal of Inflammation Research最新文献

{"title":"Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.","authors":"Yanxuan Xiao, Maliang Tao, Yiqi Yu, Ruiyan Bai, Yunting Zhuang, Qiuyu Huang, Jiexing He, Zeshan Lin, Mingze Gao, Jiaqi Li, Yuting Wang, Yao Xu, Xinyang Shen, Zhenqin Huang, Yuan Yao, Zhiyong Chen, Qian Chen, Zhijian Wang","doi":"10.2147/JIR.S538337","DOIUrl":"10.2147/JIR.S538337","url":null,"abstract":"<p><strong>Purpose: </strong>To elucidate the association between CD36 expression and senescence induced by oxidized low-density lipoprotein (ox-LDL) in patients with preeclampsia (PE).</p><p><strong>Patients and methods: </strong>We conducted a gene set enrichment analysis on RNA-sequencing data of placentas, focusing on CD36, a key gene in lipid metabolism. CD36 and ox-LDL expression were measured via qRT-PCR, Western blotting, immunohistochemistry, and immunofluorescence. We used plasmid and siRNA transfection to modulate CD36 expression in human umbilical vein endothelial cells, exposing them to ox-LDL to assess cellular senescence, oxidative stress, and angiogenesis. A co-culture system was constructed to examine how endothelial cell senescence affects trophoblast migration and invasion.</p><p><strong>Results: </strong>In patients with PE, CD36 expression significantly increased in the vascular endothelial cells of the placenta. An association was observed between elevated CD36 and ox-LDL-induced cell senescence, accompanied by intracellular oxidative stress, endothelial cell angiogenesis disorders, and decreased trophoblast function in the placenta.</p><p><strong>Conclusion: </strong>Our study has initially identified significant alterations in CD36 expression in PE placentas, which may be one of the driving factors for the occurrence of senescence. Further research is warranted to explore the mechanism between CD36 and PE-related placental senescence, which may offer novel avenues for the diagnosis and treatment of PE.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12801-12816"},"PeriodicalIF":4.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Effects of Tranexamic Acid on Perioperative Inflammation, Long-Term Functional Recovery, and Satisfaction in Total Knee Arthroplasty: A Follow-up Study.","authors":"Silong Lin, Xianqi Zhang, Xishang Xia, Guishui Xu, Hong Pan","doi":"10.2147/JIR.S532632","DOIUrl":"10.2147/JIR.S532632","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the anti-inflammatory effects and safety of Tranexamic Acid (TXA) during the perioperative period of Total Knee Arthroplasty (TKA) in patients with Knee Osteoarthritis (KOA), and to follow-up on long-term knee joint function and patient satisfaction.</p><p><strong>Methods: </strong>A prospective non-randomized controlled cohort study evaluated TXA efficacy in 130 unilateral TKA patients with KOA between January 2019 and March 2021. Patients were randomized into TXA (n=65) and control (n=65) groups. The TXA group received both intravenous and intra-articular TXA as required Postoperative coagulation profiles, day-3 systemic inflammatory markers, 6-month DVT/complication rates, and 2-year functional outcomes (knee function, QoL [Quality of Life], satisfaction) were assessed.</p><p><strong>Results: </strong>No significant differences in demographics, clinical data, or KOA severity were observed between the control and TXA groups (P>0.05). Only TXA group showed decreased post-operative Fibrinogen (FIB) levels, while Erythrocyte Sedimentation Rate (ESR)(decreased to 15.41 ±4.39 mm/h), C-reactive Protein (CRP) (decreased to 33.32 ±11.56 mg/L), and Interleukin 6 (IL-6) levels significantly decreased (decreased to 111.38 ±30.14 μg/mL) on the third day post-operation (P<0.001). During the 6 months, specific complications did not significantly differ, but the overall complication rate notably decreased in the TXA group (OR=0.23, 95% CI 0.08 to 0.61, P = 0.012). At 2-year follow-up, TXA group showed significantly better joint function and QoL (P<0.05). Postoperative satisfaction correlated with preoperative TXA use, neutrophil count, NLR, ESR, and CRP. Multivariate analysis identified TXA as an independent predictor of satisfaction (P<0.05). TXA group exhibited reduced inflammation, lower complication rates, and improved long-term outcomes, demonstrating favorable perioperative and long-term outcomes in KOA management.</p><p><strong>Conclusion: </strong>TXA has a significant effect on perioperative inflammation, long-term functional recovery and satisfaction in TKA.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12769-12781"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Value of ADC Values, Degree of Edema and the Systemic Immune-Inflammation Index for Early Postoperative Recurrence in High-Grade Gliomas.","authors":"Man Wang, Sisi Wang, Qian Li, Xili Jiang","doi":"10.2147/JIR.S533915","DOIUrl":"10.2147/JIR.S533915","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the predictive value of apparent diffusion coefficient (ADC) values, degree of edema and the systemic immune-inflammation index (SII) for early postoperative recurrence in high-grade gliomas (HGG).</p><p><strong>Methods: </strong>This retrospective study analyzed data from patients with HGG who underwent surgery at the Second People's Hospital of Hunan Province between May 2018 and June 2023. Patients were divided into early recurrence (within six months post-surgery) and non-early recurrence groups. Receiver operating characteristic (ROC) curves were used to develop predictive models for early recurrence of HGG based on ADC, degree of edema and SII.</p><p><strong>Results: </strong>A total of 68 patients with HGG were included, of whom 20 (29.5%) had early recurrence. Significant differences were observed between the early recurrence and non-early recurrence groups in age, tumor size, degree of edema, and Pathologic grading (all P < 0.05). The area under the ROC curve (AUC) for tumor ADC was 0.623 (95% CI: 0.461-0.786) with a sensitivity of 0.500 and a specificity of 0.854; for degree of edema, it was 0.652 (95% CI: 0.517-0.787) with a sensitivity of 0.900 and a specificity of 0.458; and for SII, it was 0.781 (95% CI: 0.663-0.900) with a sensitivity of 0.750 and a specificity of 0.729. The combined model yielded an AUC of 0.823 (95% CI: 0.715-0.931) with a sensitivity of 0.800 and a specificity of 0.708.</p><p><strong>Conclusion: </strong>The combined evaluation of tumor ADC values, SII, and the degree of edema offers predictive value for early recurrence in HGG.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12739-12748"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Systemic Inflammatory Biomarkers (NLR, MLR, PLR, SII, SIRI) with Preeclampsia-Related Kidney Injury: A Retrospective Observational Study.","authors":"Li-Na Gao, Dong Yan, Xiao-Hui Liu, De Chen, Hong Guo, Jian Liu","doi":"10.2147/JIR.S542136","DOIUrl":"10.2147/JIR.S542136","url":null,"abstract":"<p><strong>Background: </strong>Approximately 7-13% of pregnant women with preeclampsia (PE) develop acute kidney injury (AKI), which is one of the most serious complications of PE and is linked to long-term chronic kidney disease. This retrospective observational study investigated the association between inflammation indices and PE-related acute kidney injury (PE-AKI).</p><p><strong>Methods: </strong>This retrospective study analyzed 4071 PE patients admitted between 2013 and 2023. Inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), were derived from complete blood counts. Multivariate logistic regression assessed associations with PE-AKI risk, with nonlinear relationships characterized using restricted cubic spline models.</p><p><strong>Results: </strong>Among 4071 patients with PE, 290 (7.13%) developed AKI. Multivariate analysis (Model 3) revealed significant positive associations between log₂-transformed inflammatory indices and PE-AKI risk, with the highest odds ratios observed for MLR (OR = 6.02, 95% CI: 4.68-7.73; <i>P</i> < 0.0001) and NLR (OR = 3.93, 95% CI: 3.09-5.01; <i>P</i> < 0.0001). MLR demonstrated the strongest independent correlation with PE-AKI (highest tertile OR = 7.24, 95% CI: 4.75-11.02), followed by SIRI (OR = 5.78, 95% CI: 3.89-8.59). All indices (NLR, MLR, PLR, SII, SIRI) exhibited linear dose-response relationships with PE-AKI risk (<i>P</i>-overall <0.001 for each). Subgroup analyses further identified elevated MLR as a prominent risk factor in early-onset PE (gestational age ≤32 weeks; OR = 8.81, 95% CI: 4.91-17.10) and patients with complications (OR = 7.28, 95% CI: 5.23-10.32).</p><p><strong>Conclusion: </strong>MLR and SIRI are positively associated with PE-AKI risk, particularly in early-onset and complicated cases. This first comprehensive assessment of five biomarkers supports clinical utility. Prospective validation is required, with focus on monocyte-mediated inflammatory mechanisms.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12725-12738"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Immune-Inflammatory Biomarkers During Pregnancy and Postpartum and Adverse Outcomes of Preeclampsia: A Longitudinal Retrospective Analysis.","authors":"Xinke Guo, Weimin Tao, Qingsong Zhao, Cuicui Qu, Xiang Li, Xiaoru Sun, Zhendong Xu","doi":"10.2147/JIR.S544304","DOIUrl":"10.2147/JIR.S544304","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia (PE) is a pregnancy-specific hypertensive disorder linked to systemic inflammation. The systemic immune-inflammation index (SII), calculated from neutrophil, lymphocyte, and platelet counts, has emerged as a novel immune activation marker. Its longitudinal changes in pregnancy and predictive performance for adverse outcomes in PE are not well established.</p><p><strong>Methods: </strong>This retrospective cohort study included 692 clinical records of women with PE who delivered at Shanghai First Maternity and Infant Hospital between January 2019 and June 2024, representing 685 unique patients, 7 of whom delivered twice. SII, systemic inflammatory response index (SIRI), other inflammatory indices, and biochemical parameters were measured at four time points: the first, second, and third trimesters, and the postpartum. Linear mixed-effects models evaluated longitudinal trends, and random intercepts were used as predictors in logistic regression models assessing adverse pregnancy outcomes. All two-and three-biomarker combinations were evaluated, and DeLong's test (α = 0.05) was used to compare the area under the Receiver Operating Characteristic (ROC) curves and AUC values of each combination with that of the best single-biomarker model.</p><p><strong>Results: </strong>Among the 692 records of women with PE, 204 (29.5%) experienced adverse pregnancy outcomes. SII showed an overall increasing trend during pregnancy and demonstrated moderate predictive performance (AUC = 0.666). The combination model including SII, alanine transaminase (ALT), and creatinine (Cr) achieved the highest predictive performance (AUC = 0.712, 95% CI: 0.669-0.755, <i>P = 0.011</i>), outperforming each single-biomarker.</p><p><strong>Conclusion: </strong>SII followed an overall increasing trend during pregnancy in patients with PE and was associated with adverse pregnancy outcomes. Combining SII with ALT and Cr improved predictive performance and may be a practical tool for clinical monitoring and early intervention.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12713-12723"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue.","authors":"Xiaobo Ding, Guoxiang Li, Yuehan Yang, Zhengyao Song, Xudong Shen, Bingbing Hou, Meng Zhang, Shifang Sang, Jian Dai, Jiankang Zhang, Zongyao Hao, Yang Chen, Chaozhao Liang","doi":"10.2147/JIR.S540340","DOIUrl":"10.2147/JIR.S540340","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to construct a comprehensive single-cell transcriptomic atlas of human ureteral scar stricture tissue using single-cell RNA sequencing (scRNA-seq), to uncover cellular heterogeneity, subpopulation dynamics, and intercellular communication networks.</p><p><strong>Methods: </strong>Ureteral tissues were collected from three normal controls (CTR) and three patients with ureteral scar stricture (US). Single-cell suspensions were prepared using the MobiNova-100 platform and sequenced on the Illumina NovaSeq 6000 system. Data were analyzed using Seurat, Harmony, Monocle2 (for pseudotime trajectory analysis), CellChat (for cell-cell communication), and SCP (for GO/KEGG enrichment). Key findings were validated by multiplex immunofluorescence (IF) and immunohistochemistry (IHC).</p><p><strong>Results: </strong>Eleven major cell types were identified, including epithelial, stromal, endothelial, and immune cells, each comprising distinct subpopulations. Compared to CTR tissues, US tissues exhibited an increased proportion of S100A8⁺ and MT1E⁺ basal epithelial cells with pro-inflammatory characteristics. Fibroblasts displayed substantial heterogeneity, with expansion of inflammatory fibroblasts and smooth muscle cell subsets. Endothelial cells (ECs) showed upregulated inflammatory and antigen presentation pathways. Macrophages exhibited mixed M1/M2 polarization, with enrichment of APOE⁺ and APOBEC3A⁺ subsets. Additionally, Th17, Treg, and CD8⁺ T cell populations were elevated. Cell-cell communication analysis revealed enhanced signaling among fibroblasts, ECs, and immune subsets, particularly via PERIOSTIN, collagen, and laminin pathways.</p><p><strong>Conclusion: </strong>This study presents the first high-resolution single-cell atlas of ureteral scar stricture tissue, revealing profound cellular heterogeneity and remodeling of the immune-stromal-epithelial landscape. The findings also highlight intensified intercellular communication within the fibrotic microenvironment, offering novel insights into disease pathogenesis and potential therapeutic targets.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12749-12768"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swainsonine Protects Human Thyrocytes from Fas-Induced Apoptosis: In vitro Study on Nthy-Ori 3-1 Cell Line.","authors":"Sara Trzos, Małgorzata Opydo, Michał Bochenek, Paweł Link-Lenczowski, Ewa Pocheć","doi":"10.2147/JIR.S529858","DOIUrl":"10.2147/JIR.S529858","url":null,"abstract":"<p><strong>Background: </strong>The role of Fas is crucial for preserving immunotolerance. The mechanisms and roles of Fas/FasL signaling in the immune system are well understood, but the knowledge of how this process is regulated remains limited. Fas-mediated apoptosis is a way of thyrocyte elimination and thyroid destruction in Hashimoto's thyroiditis (HT). Proinflammatory cytokines, produced abundantly by immune cells in the thyroid in HT, stimulate the expression of Fas in thyrocytes, making them susceptible to apoptosis induced by FasL on the immune cell surface.</p><p><strong>Purpose: </strong>The present study aimed to evaluate the impact of changes in Fas <i>N</i>-glycosylation on the death of human follicular thyroid cells of the Nthy-ori 3-1 line.</p><p><strong>Methods: </strong>To induce thyrocyte apoptosis, an in vitro model was established. Cells were stimulated with IFNγ to express Fas and treated with the <i>N</i>-glycosylation inhibitors, kifunensine and swainsonine. Then apoptosis was induced by human recombinant FasL. MALDI-Tof mass spectrometry monitored kifunensine- and swainsonine-induced changes in <i>N</i>-glycosylation of Nthy-ori 3-1 thyrocytes, and cell death was analyzed using flow cytometry (annexin V staining, caspase 3/7 activity, TMRE mitochondrial membrane potential assay) and fluorescence microscopy (DAPI staining).</p><p><strong>Results: </strong>We found that swainsonine reduces Nthy-ori 3-1 cell apoptosis, caspase 3 and 7 activity, and restores mitochondrial potential. DAPI staining showed a decreased rupture and fragmentation of Nthy-ori 3-1 cell nuclei in the presence of swainsonine. The protective effect of kifunensine was only shown in the TMRE assay and for the late apoptotic cells in annexin V⁺/PI⁺ staining.</p><p><strong>Conclusion: </strong>Our study demonstrated for the first time the anti-apoptotic effect of swainsonine on follicular thyroid cell death through the Fas/FasL signaling pathway. This finding may have later applications in controlling Fas/FasL-induced thyrocyte apoptosis and preventing thyroid destruction in HT.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12677-12697"},"PeriodicalIF":4.1,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects and Mechanisms of Patchouli Alcohol on Experimental Periodontitis Rats Based on the OPG/RANK/RANKL/P38 MAPK Signaling Pathway.","authors":"Shuting Zhang, Feifei Duan, Tianzhen He, Chaoqun Sun, Menglu Zhen, Enxi Liang, Xingduo Liu, Yuqiong Dai, Ruoting Zhan, Nianchun Hu, Yun Xia, Sijun Liu","doi":"10.2147/JIR.S530534","DOIUrl":"10.2147/JIR.S530534","url":null,"abstract":"<p><strong>Background: </strong>Patchouli has been used for a long time in traditional Chinese medicine to treat inflammatory diseases, and its main active component, patchouli alcohol (PA), also has anti-inflammatory effects. However, the underlying molecular mechanism of PA in the periodontitis treatment is not well understood.</p><p><strong>Aim of the study: </strong>The primary objective of this study was to examine the effects of PA on experimental periodontitis in rats through the lens of the OPG/RANK/RANKL/p38 MAPK signaling pathway.</p><p><strong>Materials and methods: </strong>A rat model of periodontitis induced by ligation combined with LPS injection was used to evaluate the therapeutic effects of PA on periodontitis. Target prediction, target screening, intersection target identification, protein-protein interaction (PPI) network construction and topological analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, along with molecular docking were employed to predict the potential pharmacological mechanisms of PA. Micro-CT was utilized to detect alveolar bone loss, ELISA was used to measure inflammation, and qRT-PCR and Western blot were performed to further confirm its mechanisms of action.</p><p><strong>Results: </strong>Network pharmacology indicated that the p38 MAPK signaling pathway is the primary mechanism by which PA treats periodontitis. PA treatment reduced the distance between the cementum and the alveolar bone crest in rats with periodontitis. ELISA and H&E staining results showed that PA alleviated the inflammatory response and reduced the levels of IL-6, TNF-α, and IL-1β. qRT-PCR analysis revealed that PA significantly increased the mRNA expression levels of <i>RUNX2</i> and <i>OPG</i>, and decreased the mRNA expression levels of <i>RANK, RANKL, NFATc1</i>, and <i>TRAF6</i>. Western blot revealed that PA significantly reduced the expression of RANKL, RANK, and MMP9 while significantly elevating OPG expression.</p><p><strong>Conclusion: </strong>PA is an effective therapeutic strategy for periodontitis, and its mechanism of action involves inhibiting alveolar bone loss and modulating the OPG/RANK/RANKL/p38 MAPK pathway.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12599-12617"},"PeriodicalIF":4.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glasgow Prognostic Score Serves as a Prognostic Factor of Clinical Outcome in Patients with Newly Diagnosed Multiple Myeloma.","authors":"Shuzhen Li, Limei Zhang, Shutong Liu, Zhijian Liang, Weida Wang, Yun Wang, Yang Liang","doi":"10.2147/JIR.S539706","DOIUrl":"10.2147/JIR.S539706","url":null,"abstract":"<p><strong>Purpose: </strong>The Glasgow Prognostic Score (GPS), a systemic inflammation-based prognostic model incorporating C-reactive protein (CRP) and serum albumin levels, has been widely validated in solid tumors and several hematologic malignancies. However, its prognostic value in newly diagnosed multiple myeloma (NDMM) remains unclear. This study aimed to evaluate the association between GPS and survival outcomes in NDMM patients.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed a real-world cohort of 865 NDMM patients. Patients were stratified based on GPS, and overall survival (OS) and progression-free survival (PFS) were assessed by using Kaplan-Meier analysis. Cox proportional hazards models were used to determine the independent prognostic significance of GPS, adjusting for confounding factors. To compare the prognostic stratification capacity of GPS to its two modified variants, the same Kaplan-Meier analysis was applied to evaluate both the modified Glasgow Prognostic Score (mGPS) and the hypersensitivity-modified Glasgow Prognostic Score (Hs-mGPS). Quantitative comparisons utilized area under the curve (AUC) values derived from time-dependent Receiver Operating Characteristic (ROC) analysis.</p><p><strong>Results: </strong>A higher GPS was significantly associated with inferior OS and PFS in NDMM patients. Multivariate analysis confirmed that GPS was an independent prognostic factor after adjusting for disease stage and other clinical variables. Additionally, patients with elevated GPS scores presented with more advanced disease stages, as reflected by higher Durie-Salmon and International Staging System (ISS) classifications. And GPS exerts better prognostic stratification capacity than mGPS and Hs-mGPS.</p><p><strong>Conclusion: </strong>The baseline GPS at the time of diagnosis is an independent prognostic factor that negatively relates to the MM patient survival, for which GPS may serve as a supplement tool in risk stratification upon the primary medical assessment.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12699-12711"},"PeriodicalIF":4.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wheat-Grain Moxibustion Ameliorates Ulcerative Colitis: Suppressing Intestinal Inflammation, Modulating Gut Microbiota, and Restoring Mucosal Barrier Integrity.","authors":"Tao Zhu, Shi-Yue Sun, Shuo-Xin Yang, Yu-Fang Ji, Hong-Ye Wan, Lai-Xi Ji","doi":"10.2147/JIR.S540574","DOIUrl":"10.2147/JIR.S540574","url":null,"abstract":"<p><strong>Background: </strong>Wheat-grain moxibustion (Wgm), a specialized form of moxibustion therapy, exerts therapeutic effects by delivering thermal stimulation from ignited moxa wool to specific acupoints, thereby preventing or treating various diseases. Previous studies have demonstrated its beneficial role in ulcerative colitis (UC); however, the exact mechanisms involved remain to be elucidated. This study investigated the therapeutic effects of Wgm at Zhongwan (CV12), Tianshu (ST25), and Shangjuxu (ST37) sites on colonic inflammatory cytokines, intestinal mucosal barrier homeostasis, and gut microbiome profiles in UC mice.</p><p><strong>Materials and methods: </strong>A DSS-induced UC mouse model was established and Wgm at Zhongwan (CV12), Tianshu (ST25), and Shangjuxu (ST37) acupoints was conducted once a day for 7 consecutive days. The therapeutic effects of Wgm were assessed by monitoring body weight variations, disease activity index (DAI) scoring, colon length measurements, and histopathological features of colonic tissues, and the expression levels of inflammatory cytokines and intestinal mucosal barrier-related factors in colonic tissues were measured using enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), Western blotting (WB), and real-time quantitative polymerase chain reaction (RT-PCR). Additionally, 16S rRNA sequencing was performed to characterize the gut microbial community structure and diversity.</p><p><strong>Results: </strong>Wgm applied to Zhongwan (CV12), Tianshu (ST25), and Shangjuxu (ST37) significantly reduced the DAI and histological scores of colonic tissue in UC mice, while demonstrating specific efficacy in increasing body weight and colon length. By inhibiting the TLR4/MyD88/NF-κB signaling pathway, Wgm suppressed the release of intestinal inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, MPO, and COX2), downregulated intestinal injury markers (DAO, D-LA, ICAM-1, and IFABP), and upregulated mucosal barrier proteins (MUC2, ZO-1, Occludin, Claudin 1), thereby restoring intestinal mucosal barrier function and restoring the composition and diversity of the gut microbiota.</p><p><strong>Conclusion: </strong>Our results suggest that Wgm alleviates colitis by suppressing the TLR4/MyD88/NF-κB signaling pathway, reducing pro-inflammatory cytokine release, restoring intestinal mucosal barrier integrity, and modulating gut microbiome profiles. These findings collectively elucidate the potential therapeutic mechanisms by which Wgm ameliorates UC pathogenesis and demonstrate its multimodal regulatory effects in UC.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"12619-12636"},"PeriodicalIF":4.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}