Journal of Inflammation Research最新文献

{"title":"White Blood Cell Count Is Associated with Hyperuricemia in Patients with Type 2 Diabetes Mellitus.","authors":"You-Fan Peng, Han Yin, Lin Hu, Li Fang, Dian-Rong Jia, Ling Li","doi":"10.2147/JIR.S501890","DOIUrl":"10.2147/JIR.S501890","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia is highly prevalent among patients with type 2 diabetes mellitus (T2DM). Inflammation is associated with the process of hyperuricemia. However, it is unclear whether white blood cell (WBC) count, a convenient inflammatory marker, is associated with hyperuricemia in patients with T2DM. Thus, we aimed to explore the possible association between WBC count and hyperuricemia in patients with T2DM.</p><p><strong>Methods: </strong>A total of 1768 patients with T2DM were retrospectively included. Cumulative data were analyzed in patients with T2DM.</p><p><strong>Results: </strong>WBC count was significantly elevated in T2DM patients with hyperuricemia compared with those without hyperuricemia (6.80 [5.60, 8.02] vs 6.20 [5.27, 7.24] 10⁹/L, p<0.001). There was a significant positive correlation between WBC count and serum UA levels in patients with T2DM (r=0.165, 95% CI: [0.118, 0.211], p<0.001). Multivariable logistic regression analysis revealed an independent association between WBC count and hyperuricemia in patients with T2DM (OR=1.185, 95% CI: [1.077, 1.303], p<0.001).</p><p><strong>Conclusion: </strong>Elevated WBC count, even within the normal range, is associated with hyperuricemia in patients with T2DM, suggesting that chronic inflammation, as indicated by a higher WBC count, may be related to the development of hyperuricemia in patients with T2DM and urate-lowering therapy may be helpful to ameliorate chronic inflammatory damage in T2DM patients with hyperuricemia.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3993-3999"},"PeriodicalIF":4.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-126-5p Down-Regulation Alleviates the Inflammatory Response of Allergic Rhinitis in Children via Inhibiting HIPK2/NF-κB Signaling Pathway.","authors":"Yunlong Jing, Jiang Xie, Songliang Long, Min Huang","doi":"10.2147/JIR.S507828","DOIUrl":"10.2147/JIR.S507828","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of our study was to exploit the potential mechanism of microRNA-126-5p (miR-126-5p) in the occurrence and formation of allergic rhinitis (AR) in children.</p><p><strong>Patients and methods: </strong>Nasal mucosal tissues were obtained from AR in children and patients with adenoidectomy. Human nasal epithelial cell line (RPMI-2650) and BALB/c mice models were, respectively, established via ovalbumin (OVA) stimulation. Target genes and proteins levels were determined through quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) assays. The interaction of miR-126-5p with homeodomain-interacting protein kinase 2 (HIPK2) was confirmed via dual-luciferase reporter detection.</p><p><strong>Results: </strong>MiR-126-5p was memorably increased in nasal mucosal tissue specimens of AR children compared with patients with adenoidectomy, while HIPK2 was distinctly declined (all P<0.05). A negative association was found between miR-126-5p and HIPK2 expression (r=-0.5757, P<0.001). Moreover, HIPK2 was predicted to be targeted by miR-126-5p. Proinflammatory cytokines expressions were significantly increased, and anti-inflammatory cytokines were obviously decreased in AR RPMI-2650 cell model (P<0.001). NF-κB signaling pathway was also activated in AR RPMI-2650 cell model. MiR-126-5p inhibitor mitigated the stimulated function by OVA. Silencing HIPK2 recused miR-126-5p inhibitor phenomena in AR RPMI-2650 cell model. Furthermore, in vivo experiments further verified in vitro results, documenting that miR-126-5p inhibitor and si-HIPK2 relieved AR in the mice model.</p><p><strong>Conclusion: </strong>MiR-126-5p down-regulation relieved inflammation response and events of AR in children and mice model of AR through HIPK2/NF-κB signaling pathway, suggesting being a latent therapeutic target in AR.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3981-3992"},"PeriodicalIF":4.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Liquid-Liquid Phase Separation and Its Mechanisms in Sepsis.","authors":"Meiling Cao, Xinyi Zhang, Xiaohan Wang, Danyang Zhao, Mingyue Shi, Jiahui Zou, Lei Li, Hongkun Jiang","doi":"10.2147/JIR.S513098","DOIUrl":"10.2147/JIR.S513098","url":null,"abstract":"<p><p>Sepsis is a systemic inflammatory response syndrome triggered by the invasion of bacteria or pathogenic microorganisms into the human body, which may lead to a variety of serious complications and pose a serious threat to the patient's life and health. Liquid-liquid phase separation (LLPS) is a biomolecular process in which different biomolecules, such as proteins and nucleic acids, form liquid condensates through interactions, and these condensates play key roles in cellular physiological processes. LLPS may affect the development of sepsis through several pathways, such as modulation of inflammatory factors, immune responses, and cell death, by altering the function or activity of biomolecules, which, in turn, affect the cellular response to infection and inflammation. In this paper, we first discuss the mechanism of phase separation, then summarize the studies of LLPS in sepsis, and finally propose the potential application of LLPS in sepsis treatment strategies, while pointing out the limitations of the existing studies and the directions for future research.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3969-3980"},"PeriodicalIF":4.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Editing: An Effective Tool for the Future Treatment of Kidney Disease.","authors":"Mei-Ling Cao, Rui-Yi Han, Si-Da Chen, Dan-Yang Zhao, Ming-Yue Shi, Jia-Hui Zou, Lei Li, Hong-Kun Jiang","doi":"10.2147/JIR.S506760","DOIUrl":"10.2147/JIR.S506760","url":null,"abstract":"<p><p>Gene editing technology involves modifying target genes to alter genetic traits and generate new phenotypes. Beginning with zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN), the field has evolved through the advent of clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems, and more recently to base editors (BE) and prime editors (PE). These innovations have provided deep insights into the molecular mechanisms of complex biological processes and have paved the way for novel therapeutic strategies for a range of diseases. Gene editing is now being applied in the treatment of both genetic and acquired kidney diseases, as well as in kidney transplantation and the correction of genetic mutations. This review explores the current applications of mainstream gene editing technologies in biology, with a particular emphasis on their roles in kidney disease research and treatment of. It also addresses the limitations and challenges associated with these technologies, while offering perspectives on their future potential in this field.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"4001-4018"},"PeriodicalIF":4.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-214-3p Promotes ox-LDL-Induced Macrophages Ferroptosis and Inflammation via GPX4.","authors":"Xueliang Pei, Facai Cui, Yu Chen, Zhiyuan Yang, Zhouliang Xie, Yongjin Wen","doi":"10.2147/JIR.S507076","DOIUrl":"10.2147/JIR.S507076","url":null,"abstract":"<p><strong>Purpose: </strong>Atherosclerosis (AS) is a chronic inflammatory disease caused by the dysregulation of lipid metabolism. It has been established that oxidized low-density lipoprotein (ox-LDL)-induced macrophage inflammation and ferroptosis play important roles in AS. However, the mechanism by which ox-LDL induces inflammation in macrophages requires further investigation.</p><p><strong>Materials and methods: </strong>A foam cell model derived from ox-LDL-induced macrophages was constructed to study its mechanism of action. The levels of interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were evaluated using an Enzyme-Linked Immunosorbent Assay (ELISA). Oil Red O staining was used to detect intracellular lipid accumulation levels. Lactate dehydrogenase (LDH), malondialdehyde (MDA), reactive oxygen species (ROS), and Fe²⁺ levels were assessed. Dual-luciferase and RNA-binding protein immunoprecipitation (RIP) experiments validated the binding relationship between microRNA (miR)-214-3p and glutathione peroxidase 4 (GPX4).</p><p><strong>Results: </strong>The levels of IL-6, IL-1β, and TNF-α were significantly increased in ox-LDL-induced macrophages, accompanied by increased lipid accumulation, indicating the promotion of foam cell formation. Additionally, ox-LDL increased LDH, MDA, ROS, and Fe²⁺. The expression of miR-214-3p positively correlated with ox-LDL concentration in macrophages. Treatment with an miR-214-3p inhibitor reduces lipid accumulation, inflammatory responses, and ferroptosis in macrophages. Dual-luciferase and RIP experiments confirmed that miR-214-3p regulates GPX4 transcription. Silenced GPX4 reversed the inflammatory effects of the miR-214-3p inhibitor on ox-LDL-induced macrophages. Low GPX4 expression also increased lipid accumulation and ferroptosis in macrophages.</p><p><strong>Conclusion: </strong>miR-214-3p promotes macrophage ferroptosis and inflammation induced by ox-LDL. This mechanism may be associated with miR-214-3p-induced GPX4 expression, which underscores the therapeutic significance of targeting macrophage inflammation and ferroptosis in addressing AS.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3937-3950"},"PeriodicalIF":4.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Identification of CD74 as a Biomarker for Diagnosing and Prognosing Sepsis Patients.","authors":"Kaibo Hu, Ao Shi, Yuan Shu, Shivon Sudesh, Jitao Ling, Yixuan Chen, Fuzhou Hua, Shuchun Yu, Jing Zhang, Peng Yu","doi":"10.2147/JIR.S509089","DOIUrl":"10.2147/JIR.S509089","url":null,"abstract":"<p><strong>Purpose: </strong>Sepsis, a life-threatening inflammatory condition due to an imbalanced response to infections, has been a major concern. Necroptosis, a newly discovered programmed cell death form, plays a crucial role in various inflammatory diseases. Our study aims to identify necroptosis - related genes (NRGs) and explore their potential for sepsis diagnosis.</p><p><strong>Patients and methods: </strong>We used weighted gene co-expression network analysis to identify gene modules associated with sepsis. Cox regression and Kaplan-Meier methods were employed to assess the diagnostic and prognostic value of these genes. Single-cell and immune infiltration analyses were carried out to explore the immune environment in sepsis. Plasma CD74 protein levels were quantified in our samples, and relevant clinical data from electronic patient records were analyzed for correlation.</p><p><strong>Results: </strong>CD74 was identified through the intersection of the hub genes of sepsis and NRGs related modules. Septic patients had lower CD74 expression compared to healthy controls. The CD74-based diagnostic model showed better performance in the training dataset (AUC, 0.79 [95% CI, 0.75-0.84]), was cross-validated in external datasets, and demonstrated better performances than other published diagnostic models. Pathway analysis and single-cell profiling supported further exploration of CD74-related inflammation and immune response in sepsis.</p><p><strong>Conclusion: </strong>This study presents the first quantitative assessment of human plasma CD74 in sepsis patients. CD74 levels were significantly lower in the sepsis cohort. CD74 warrants further exploration as a potential prognostic and therapeutic target for sepsis.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3829-3842"},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Predictive Performance of MLPAS and CCMLP for Clinical Outcome and Risk Stratification in Patients with Colorectal Cancer.","authors":"Qiu-Ying Ye, Yuan-Yuan Wang, Zhi-Jie Wang, Min Lu, Hong-Xin Peng, Xin Wang, Xue-Xin Cheng, Hou-Qun Ying","doi":"10.2147/JIR.S498028","DOIUrl":"10.2147/JIR.S498028","url":null,"abstract":"<p><strong>Background: </strong>There is no recognized biomarker is recommended to monitor or predict the prognosis of colorectal cancer (CRC) patients with negative detection of carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA19-9) and to classify high recurrence-risk cases.</p><p><strong>Methods: </strong>Discovery and two-stage validation cohorts, which included 2111 radically resected patients with stage II-III CRC, were enrolled in this study. We detected preoperative peripheral monocyte, platelet, albumin (Alb), pre-albumin (pAlb), CEA, and CA19-9 and investigated the prognostic and risk-stratified roles of twelve new inflammatory biomarkers in the three cohorts.</p><p><strong>Results: </strong>In our study, monocyte-to-pAlb ratio (MPAR), monocyte-to-lymphocyte -to-Alb ratio (MLAR), monocyte-to-lymphocyte-to-pAlb ratio (MLPAR), monocyte- to-pAlb score (MPAS), lymphocyte-to-monocyte-Alb score (MLAS), lymphocyte-to monocyte-pAlb score (MLPAS), and platelet-to-lymphocyte-Alb score (PLAS) were significantly associated with both RFS and OS in three cohorts. MLPAS showed the best performance in predicting RFS and OS, and it was related to right-tumor location and significant cancer burden (≥5cm) in the overall population. Moreover, MLPAS is a robust prognostic biomarker in subgroups stratified by CEA or CA19-9. Patients with scores zero and two of the CEA-CA19-9-MLPAS score (CCMLP) showed the lowest and highest recurrence and death rates, respectively, and significant survival differences were observed between them.</p><p><strong>Conclusion: </strong>MLPAS is an optimal, independent, and robust prognostic biomarker in the stage II-III CRC population, especially with negative CEA or CA19-9. The CCMLP could effectively classify high recurrence-risk patients who require more focus, monitoring, and treatment for the clinic.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3889-3900"},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of <i>RSAD2</i> as a Key Biomarker Linking Iron Metabolism and Dendritic Cell Activation in Systemic Lupus Erythematosus Through Bioinformatics and Experimental Validation.","authors":"Hengrong Qian, Sheng Gao, Ting Zhang, Yuanyuan Xie, Siyan Chen, Yanggang Hong, Xinlei Wu, Zhouhang Xing, Lingjie Kong, Jintao Mo, Yiming Lin, Anzhe Zheng, Wenqian Wang, Liangxing Wang, Chunyan Hua","doi":"10.2147/JIR.S500115","DOIUrl":"10.2147/JIR.S500115","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is characterized by aberrant immune activation and disrupted iron metabolism, yet the molecular mediators that govern both processes remain unclear. This study aims to identify pivotal genes that modulate immune responses and iron metabolism, and to delineate their contributions to SLE pathogenesis.</p><p><strong>Methods: </strong>Differentially expressed genes related to iron metabolism (IM-DEGs) were identified using datasets (GSE72326, GSE110169, GSE126307, and GSE50772) from the GEO database and the MSigDB. Functional enrichment analyses were performed on the iron metabolism related genes (IM-Genes). A weighted gene co-expression network analysis was constructed to identify hub genes, which were further refined as potential biomarkers using the least absolute shrinkage and selection operator method. The predictive value of these biomarkers was validated using receiver operating characteristic (ROC) curves and the nomogram. CIBERSORT was employed to evaluate immune cell infiltration in SLE. Additionally, the expression and function of <i>RSAD2</i> were confirmed using RNA interference, quantitative real-time PCR, and Western blotting techniques.</p><p><strong>Results: </strong>Bioinformatics analyses identified 4 potential biomarkers: <i>RSAD2, MT2A, LCN2</i>, and <i>LTF. RSAD2</i> exhibited the highest clinical validity (AUC = 0.927) and was closely associated with classic diagnostic indicators. Its diagnostic potential was confirmed through ROC curve and nomogram, highlighting its role in SLE pathogenesis. Elevated <i>RSAD2</i> expression was observed in peripheral blood mononuclear cells of SLE patients, positively correlating with activated dendritic cells (DCs). Notably, <i>Rsad2</i> knockdown markedly impaired the function of activated DCs, as evidenced by suppressed expression of inflammatory mediators and iron metabolism-related genes.</p><p><strong>Conclusion: </strong>Our findings suggest that <i>RSAD2</i> is a potential diagnostic biomarker and therapeutic target for SLE, elucidating the intricate relationship between immune dysregulation and aberrant iron metabolism in activated DCs, which exacerbates SLE.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3859-3878"},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Involvement in Idiopathic Inflammatory Myopathies.","authors":"Hongji Zhu, Runzhao Li, Hongxia Tan, Tangdan Ding, Ying Yuan, Zhihua Wen, Jijun Zhao, Min Liu, Qiong Shi, Liubing Li","doi":"10.2147/JIR.S503928","DOIUrl":"10.2147/JIR.S503928","url":null,"abstract":"<p><p>Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune diseases that includes the main subtypes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and inclusion body myositis. IIMs are characterized by the involvement of skeletal muscle and multiple organs, including the heart. This review summarizes the pathology, prevalence, biomarkers, imaging and treatment of cardiac involvement in patients with IIMs. The cardiac involvement in these patients is usually subclinical and rarely considered as the main clinical feature at the time of initial consultation, with a prevalence ranging from 4% to 26%. However, it results in a worse prognosis and represents the main cause of mortality in patients with IIMs. The selection of specific serum cardiac biomarkers is essential for the early detection of cardiac involvement in patients with IIMs, such as cardiac troponin I (cTnI), which is preferred over cardiac troponin T (cTnT), followed by diagnostic evaluations including electrocardiography (ECG), echocardiography (ECHO), and cardiac magnetic resonance imaging (CMR). The combination of glucocorticoids, immunosuppressants, and conventional cardiac medications is effective for the management of IIM patients with confirmed cardiac involvement.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3879-3888"},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tryptase as a Biomarker for Adverse Prognosis in ST-Segment Elevation Myocardial Infarction Patients: A Prospective Cohort Study.","authors":"Pengxin Xie, Shuwan Xu, Xi Chen, Hong Xu, Ruitao Zhang, Dan Li, Lijie Sun, Dan Zhu, Ming Cui","doi":"10.2147/JIR.S502496","DOIUrl":"10.2147/JIR.S502496","url":null,"abstract":"<p><strong>Background: </strong>Acute ST-segment elevation myocardial infarction (STEMI) is characterized by a rapid inflammatory response, with mast cells (MCs) playing a significant role. However, the relationship between MC activation and the adverse outcomes remains unclear. This study investigated the association between the MC activation biomarker, tryptase, and major adverse cardiovascular events (MACE).</p><p><strong>Methods: </strong>This prospective study included patients with STEMI who underwent primary percutaneous coronary intervention (PPCI) at Peking University Third Hospital between July 2020 and July 2023. Tryptase levels were detected from plasma samples collected 6 hours post-PPCI and using ELISA method. All patients were followed up every 6 months, with MACE as the primary endpoint.</p><p><strong>Results: </strong>The study enrolled 514 patients with STEMI who underwent PPCI (mean age: 59.27 ± 13.26 years, 16.93% female). The median follow-up time was 13.28 (10.47-37.61) months, during which 85 patients (16.54%) experienced MACE. Patients in the higher tryptase group had a higher risk of MACE (HR 2.60 [1.68-4.01], P < 0.001). Tryptase was an independent risk factor of MACE (HR 1.56 [1.29-1.88] per 1-unit increase, P < 0.001). Subgroup analysis revealed the prognostic value of tryptase among different age groups, left ventricular ejection levels, and patients with hypertension, hyperlipidemia, smoking and diabetes. The addition of tryptase to the basic model had an incremental effect on the predictive value for MACE (AUC: 0.763 vs 0.702, P = 0.002).</p><p><strong>Conclusion: </strong>In this study, elevated tryptase levels, a biomarker of MC activation, were identified as a significant predictor of MACE in STEMI patients undergoing PPCI.</p><p><strong>Trial registration: </strong>(ClinicalTrials.gov NCT05802667).</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3817-3828"},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}