Journal of Inflammation Research最新文献

{"title":"Heightened Innate Immune and Inflammatory Gene Expression in the Skin of Severe COVID-19 Cases.","authors":"Iara Grigoletto Fernandes, Frederico Moraes Ferreira, Emanuella Sarmento Alho De Sousa, Anna Julia Pietrobon, Franciane Mouradian Emidio Teixeira, Yasmim Álefe Leuzzi Ramos, Tatiana Mina Yendo, Natalli Zanete Pereira, Mirian Nacagami Sotto, Amaro Nunes Duarte-Neto, Raquel Leão Orfali, Valeria Aoki, Luiz Fernando Ferraz Da Silva, Alberto José da Silva Duarte, Maria Notomi Sato","doi":"10.2147/JIR.S516737","DOIUrl":"https://doi.org/10.2147/JIR.S516737","url":null,"abstract":"<p><strong>Purpose: </strong>Cutaneous manifestations of SARS-CoV-2 infection exhibit significant variability, yet the role of innate immune responses in the skin of COVID-19 patients remains poorly understood. In this study, we investigated the transcriptomic profile of skin samples from patients who succumbed to COVID-19.</p><p><strong>Patients and methods: </strong>Skin autopsies from COVID-19 patients with post-mortem time of less than 20 hours were obtained from University of São Paulo Medical School Hospital and healthy skin samples, were submitted to RNA sequencing analysis. Validation of differentially expressed genes (DEGs) was performed by real-Time PCR.</p><p><strong>Results: </strong>Our analysis revealed markedly elevated expression of type I interferon (IFN)-inducible antiviral factors, antioxidant enzymes, and components of several cytokine-signaling pathways in COVID-19 skin samples compared to healthy controls. SARS-CoV-2 infection robustly induced numerous interferon-stimulated genes (ISGs), IFITs, IRF, S100 family with a notable enrichment of those associated with antiviral and inflammatory responses. Moreover, the presence of counter-regulatory factors such as SOCS3 and NFKBIA indicate the involvement of anti-inflammatory mechanisms in the skin. Furthermore, deconvolution data indicated increased presence of macrophages other nucleated cells in vessels in the skin of COVID-19 patients, highlighting the involvement of innate immune mechanisms.</p><p><strong>Conclusion: </strong>The results revealed cutaneous alterations in the expression of genes associated with innate immunity and inflammation factors. This suggests that, unlike tissues with viral tropism, the skin is enriched with antiviral factors to defend against SARS-CoV-2. This information could be useful for developing specific antiviral therapies.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9119-9128"},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Identification of Pediatric Inflammatory Bowel Disease Based on a Noninvasive Multivariable Predictive Model.","authors":"Hailin Wu, Yinghua Sun, Zifei Tang, Xiaojiao Qin, Yuhuan Wang, Ying Huang","doi":"10.2147/JIR.S529537","DOIUrl":"https://doi.org/10.2147/JIR.S529537","url":null,"abstract":"<p><strong>Background: </strong>Early identification of pediatric inflammatory bowel disease (IBD) improves long-term outcomes; yet, significant diagnostic delays persist. This study aimed to establish and validate the optimal model of noninvasive evaluation tests to help clinicians with the early identification of pediatric IBD.</p><p><strong>Methods: </strong>The study adopted a retrospective development and prospective temporal validation design within the same clinical center. A cohort of 314 pediatric patients (IBD, 103; non-IBD, 211) was used to develop a logistic regression model. The model based on noninvasive features, including IBD-related symptoms, routine laboratory tests, and transabdominal ultrasound findings. Ultrasound parameters included Limberg score >1 (bowel wall thickening with blood flow), increased mesenteric fat, disrupted wall layering, and enlarged lymph nodes. The ultrasound operator was blinded to laboratory and endoscopic results. Feature selection was performed using logistic regression and random forest methods. Model performance was assessed via bootstrapped internal validation (1000 resamples), and temporally validated in a prospective cohort of 66 children (IBD, 19; non-IBD, 47).</p><p><strong>Results: </strong>In the importance assessment, the ultrasound feature of Limberg level >1 was identified as the most valuable feature, followed by the erythrocyte sedimentation rate, fecal calprotectin, C-reactive protein and hypoalbuminemia. The most valuable clinical symptom identified was active perianal abscess or fistula. The model, constructed from these features, demonstrated high accuracy and robustness in both internal validation (area under the curve, 0.97 [95% confidence interval: 0.95-0.98]) and temporal external validation (area under the curve, 0.94 [95% confidence interval: 0.86-1.00]). In the external validation set, the model showed good calibration, with a calibration slope of 0.86, and a Brier score of 0.08.</p><p><strong>Conclusion: </strong>The nomogram, based on noninvasive factors, can identify children with IBD at early stages using accessible noninvasive testing.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9107-9118"},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Serum Bilirubin and Total Bile Acids During Biologic Therapy in Patients with Ulcerative Colitis: A Retrospective Study.","authors":"Zhengyu Ren, Zhewei Zhang, Haichen Li, Pumeng Fu, Ruixue Wang, Siyao Wang, Yingchao Li","doi":"10.2147/JIR.S524056","DOIUrl":"https://doi.org/10.2147/JIR.S524056","url":null,"abstract":"<p><strong>Purpose: </strong>Ulcerative colitis (UC) requires new non-invasive serum biomarkers for assistance in monitoring due to the low rate of endoscopic follow-up. Previous research indicated reduced levels of serum indirect bilirubin (sIBIL), serum total bilirubin (sTBIL), and serum total bile acids (sTBAs) in UC patients. This study aims to assess their monitoring potential in UC during biologic therapy.</p><p><strong>Methods: </strong>We conducted a retrospective single-center study including 138 UC patients and 150 controls with normal colonoscopy results. The receiver operating characteristic (ROC) curve was used to assess diagnostic value of sIBIL, sTBIL, and sTBAs. Spearman correlation analysis was performed to assess the association between these biomarkers and the severity of both endoscopic findings and clinical symptoms in UC patients. Additionally, changes in serum biomarkers were analyzed in 72 UC patients during biologic therapy, with stratified analyses based on endoscopic remission status.</p><p><strong>Results: </strong>Patients with UC exhibited lower concentrations of sIBIL, sTBIL, and sTBAs compared to the controls (<i>P</i> < 0.05), and all these biomarkers demonstrated moderate diagnostic value in identifying UC from normal controls (<i>P</i> < 0.05). sIBIL concentration negatively correlated with disease severity and showed a progressive increase during biologic therapy, particularly in patients achieving endoscopic remission at week 52 (<i>P</i> < 0.05). The sIBIL concentration in the remission group was significantly higher than that in the non-remission group after week 26 (<i>P</i> < 0.05). For sTBAs, concentration initially increased and then decreased, with a turning point at week 14 in the remission group (<i>P</i> < 0.05) and at week 26 in the non-remission group (<i>P</i> > 0.05). No significant differences in sTBAs concentrations were found between remission and non-remission groups at any time (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>sIBIL may be used as a valuable serum biomarker for the clinical diagnosis and the monitoring of response to biologics. Additionally, the change trend of sTBAs may provide reference value for monitoring UC biologic therapy. However, further studies are needed to analyze the changes in its internal composition.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9079-9090"},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAR-Based Prognostic Model for Predicting Overall Survival in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study.","authors":"Maoqing Tan, Yifan Liu, Wei Dai, Yanling Chen, Danni Cai, Baomin Chen, Jing Wang, Ruolan You, Dongliang Li, Huifang Huang","doi":"10.2147/JIR.S527420","DOIUrl":"https://doi.org/10.2147/JIR.S527420","url":null,"abstract":"<p><strong>Purpose: </strong>Hepatitis B virus-related hepatocellular carcinoma poses a significant global health challenge. This study aimed to develop and validate a novel prognostic nomogram integrating the red blood cell distribution width-to-albumin ratio for predicting patients' overall survival.</p><p><strong>Patients and methods: </strong>A retrospective cohort of 1403 patients was divided into training, internal validation, and external validation cohorts. A multivariate Cox regression model selected variables to construct a nomogram and an online calculator, which were subsequently validated.</p><p><strong>Results: </strong>The ratio emerged as an independent risk factor for long-term survival (hazard ratio: 5.808, 95% confidence interval: 1.721-19.599). A prognostic nomogram incorporating nine variables based on the ratio was developed. Calibration curves demonstrated high concordance between the predicted and actual 3-year survival rates. Decision curve analysis indicated that the nomogram significantly increased the net benefit of predicting 3-year survival. Based on the area under the receiver operating characteristic curves, the nomogram outperformed traditional models in predicting survival across the three cohorts. Patients were stratified into low-, intermediate-, and high-risk groups based on risk scores calculated from the nomogram. In all cohorts, the median survival time of the high-risk group was significantly shorter than that of the intermediate- and low-risk groups. An online calculator, deployed via a web-based platform, facilitated convenient mortality risk prediction for these patients.</p><p><strong>Conclusion: </strong>The ratio-based nomogram we developed can accurately predict the survival of patients with hepatitis B virus-related hepatocellular carcinoma, serving as an effective auxiliary tool for clinical personalized treatment and prognostic assessment.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9159-9170"},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role and Mechanism of Protein Post‑Translational Modification in Rheumatoid Arthritis.","authors":"Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang","doi":"10.2147/JIR.S528487","DOIUrl":"https://doi.org/10.2147/JIR.S528487","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic autoimmune disease that significantly compromises patient quality of life due to its high prevalence and risk of disability. While its etiology remains incompletely understood, increasing evidence highlights the critical involvement of epigenetic mechanisms, particularly post-translational modifications (PTMs), in RA pathogenesis. Advances in proteomics have identified various PTMs-including phosphorylation, methylation, acetylation, ubiquitination, glycosylation, lactylation, as well as citrullination and carbamylation-as key regulators of inflammation, immune response, and tissue remodeling in RA. Importantly, dysregulated PTMs may alter protein structure and function, thereby contributing to disease progression. This review systematically summarizes current knowledge on the roles and mechanisms of major PTMs in RA, with a special focus on the cross-talk between PTMs, their interaction with non-coding RNAs, and the emerging therapeutic potential of traditional Chinese medicine (TCM) targeting PTMs. These insights may provide novel perspectives for the diagnosis and treatment of RA.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9055-9078"},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modulation of Neuroimmune Responses in Peripheral Inflammation.","authors":"Jing Wang, Dandan Ji, Ninan Dai, Chang Qin, Mingyang Gong, Bao Fu","doi":"10.2147/JIR.S533106","DOIUrl":"10.2147/JIR.S533106","url":null,"abstract":"<p><p>The brain, as the \"commander-in-chief\" of the human body, is known to pick up the peripheral situation and dictate orders to the periphery on time, and the immune system makes no exception. Inflammation is a defensive reaction of the body, which can be beneficial, however, unrestricted inflammation can result in life-threatening injuries and multi-organ dysfunction. The intricate interaction between the nervous and the immune system would prevent inflammation from spreading indefinitely. The onset of life-threatening bursts of inflammation may indicate neurological dysregulation, at which point additional interventions are necessary to establish a new balance. However, these interventions must be predicated on an understanding of the neuroimmune communication. Consequently, we provide a comprehensive pathway that illustrates how the central nervous system detects peripheral inflammatory signals that are transmitted by nerves or related substances and subsequently regulates peripheral inflammation through the autonomic nervous system and neuroendocrine system, intending to discover new methods of treating peripheral inflammation by intervening the nervous system.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9015-9030"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of Insulin Resistance and Systemic Inflammation with Cardiovascular Outcomes in Non-Diabetic Patients Undergoing Coronary Artery Bypass Grafting.","authors":"Yingying Xie, Hao Chen, Yanxiang Gao, Haoming He, Zhe Wang, Yaru Zhang, Qiaochu Zhou, Ling Liu, Jingang Zheng","doi":"10.2147/JIR.S514852","DOIUrl":"10.2147/JIR.S514852","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) is linked to adverse cardiovascular outcomes, but its mechanisms are not fully understood. This study investigates the relationship between IR and systemic inflammation and evaluates how systemic inflammation affects the correlation between IR and prognosis in non-diabetic patients undergoing coronary artery bypass grafting (CABG).</p><p><strong>Methods: </strong>This study enrolled 1,658 patients post-CABG. IR was assessed via the estimated glucose disposal rate (eGDR), and systemic inflammation was measured by C-reactive protein (CRP) levels. The correlation between eGDR and CRP was analyzed using linear regression. Associations of eGDR and CRP with major adverse cardiovascular and cerebrovascular events (MACCEs) were evaluated through the Kaplan-Meier method, restricted cubic splines (RCS), and adjusted Cox regression analyses. A novel two-stage regression method for survival data was used in the mediation analysis.</p><p><strong>Results: </strong>Over a median follow-up period of 60.9 months, 414 MACCEs cases were documented. The RCS analysis revealed an L-shaped association between eGDR and MACCEs with an approximate threshold of 8 mg/kg/min, whereas CRP exhibited a linear positive dose-response relationship with MACCEs. Compared with individuals in the high eGDR and low CRP group (eGDR > 8 and CRP < 3), those in the low eGDR and high CRP group (eGDR ≤ 8 and CRP ≥ 3) showed the highest risk for MACCEs (hazard ratio [HR] = 2.282, 95% confidence interval [CI] 1.749-2.978). Mediation analysis indicated that CRP levels mediated 12.3% of the correlation between eGDR and MACCEs.</p><p><strong>Conclusion: </strong>eGDR showed a negative correlation with CRP levels, and their synergistic relationship enhanced the prediction of MACCEs in non-diabetic patients undergoing CABG. Additionally, CRP levels partially mediated the association between eGDR and MACCEs. Anti-inflammatory treatment for non-diabetic individuals with high IR who underwent CABG may offer further benefits.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9031-9043"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aneurysm Wall Enhancement and Systemic Inflammation Jointly Contribute to Cognitive Dysfunction in Untreated Unruptured Intracranial Aneurysm Patients.","authors":"Xiao-Bing Wu, Bin Luo, Xin Guo, Chi-Chen Liu, Yi-Ao Liu, Jie-Shun Ye, Shao-Yi Fan, Qing-Jian Li, Sheng-Wen Wang","doi":"10.2147/JIR.S515856","DOIUrl":"10.2147/JIR.S515856","url":null,"abstract":"<p><strong>Background and purpose: </strong>Peripheral inflammatory markers and aneurysm wall enhancement (AWE) on high-resolution vessel wall MRI (HR-VWI) may reflect inflammation in unruptured intracranial aneurysms (UIAs). We assessed cognitive function and its association with inflammatory markers in UIA patients.</p><p><strong>Methods: </strong>The study included 120 consecutive patients with UIAs diagnosed between September 2018 and December 2023 and a control group of 27 healthy adults at our institution. Neuropsychological function in these patients was evaluated using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Scale (HAMA), and Self-Rating Depression Scale (SDS). A MoCA score of <23 was classified as cognitive decline, while scores of ≥23 indicated normal cognitive function. The peripheral blood inflammatory markers and radiological characteristics were compared between the patients with cognitive decline and those with normal cognitive function. The presence of AWE and white matter hyperintensities (WMH) in UIA was identified through HR-VWI.</p><p><strong>Results: </strong>UIA patients demonstrated significantly poorer cognitive performance than controls, with lower MMSE (27.0 vs 29.0, P < 0.001) and MoCA scores (23.0 vs 25.0, P = 0.020). Patients with cognitive decline were older and exhibited elevated inflammatory markers (NLR, SII, hsCRP; all P < 0.05), along with higher rates of AWE and white matter hyperintensities (WMH) (both P < 0.001). Multivariate analysis identified AWE (OR = 5.33, 95% CI:1.82-15.59), WMH (OR = 4.26, 95% CI:1.58-11.49), and age (OR = 1.07, 95% CI:1.02-1.12) as independent predictors of cognitive decline (all P ≤ 0.01). Moreover, the cognitive decline group also showed higher SDS and HAMA scores (P < 0.05), suggesting a correlation between emotional distress and cognitive impairment.</p><p><strong>Conclusion: </strong>Untreated UIA patients exhibit cognitive decline associated with systemic inflammation (NLR, SII, hs-CRP). AWE, WMH and age are independent risk factors, suggesting vascular inflammation contributes to cognitive dysfunction.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9045-9053"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome.","authors":"Tianyan Chen, Yawen Liu, Yuan Liu, Nannan Hu, Yan Dai, Chuanlong Zhu, Yaping Han, Ke Jin, Jun Li","doi":"10.2147/JIR.S520425","DOIUrl":"10.2147/JIR.S520425","url":null,"abstract":"<p><strong>Purpose: </strong>Hyperactive immune responses in severe fever with thrombocytopenia syndrome (SFTS) is considered to associated with disease severity, prognosis and complications. This article aims to evaluate the validity of complement C3a, C5a, and sC5b-9 in predicting the severity and clinical outcomes in SFTS.</p><p><strong>Patients and methods: </strong>Patients diagnosed with SFTS at the First Affiliated Hospital with Nanjing Medical University from March to November 2021 were enrolled in this retrospective analysis. The study evaluated C3a, C5a, and sC5b-9 levels between SFTS patients and healthy controls. The diagnostic and prognostic efficiency of C3a, C5a, and sC5b-9 for SFTS was assessed utilizing receiver operating characteristic (ROC) curve analysis. Correlation analysis was performed to examine the relationships between these complement components and clinical laboratory parameters in SFTS patients.</p><p><strong>Results: </strong>A total of 67 hospitalized SFTS patients were enrolled. SFTS patients exhibited significantly higher concentrations of C3a, C5a, and sC5b-9 compared to healthy controls. Non-survival and severe SFTS patients had notably higher C3a and sC5b-9 levels than survival and mild, respectively. ROC curve analysis revealed that C3a and sC5b-9 demonstrated effective performance for distinguishing severity in SFTS patients, with the area under the curve (AUC) of 0.784 (95% CI: 0.671-0.896, <i>p</i> < 0.001) and 0.703 (95% CI: 0.573-0.832, <i>p</i> = 0.005), respectively. The correlation analysis indicated that C3a and sC5b-9 positively correlated with SFTS RNA, CRP, PCT, ALT, AST, ALP, LDH, CK, HBDH, APPT, TT and D-dimer, while C3a negatively correlated with PLT.</p><p><strong>Conclusion: </strong>This study revealed abnormalities in complement components among patients with SFTS. C3a and sC5b-9 levels show promise as biomarkers for linking with disease severity and prognosis, potentially providing therapeutic targets for the management of SFTS patients and guide future mechanistic research.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"9001-9014"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for Predicting Postoperative Cardiopulmonary Complications in Non-Small Cell Lung Cancer Based on Systemic Inflammatory Markers: A Retrospective Study.","authors":"Zemin He, Keting Liu, Ling Wu, Qiang Wei","doi":"10.2147/JIR.S519449","DOIUrl":"10.2147/JIR.S519449","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to investigate the association between systemic inflammatory markers and postoperative cardiopulmonary complications in patients with non-small cell lung cancer (NSCLC). Additionally, the study aims to develop a column chart tool to improve the accuracy of predicting the risk of postoperative cardiopulmonary complications in NSCLC patients.</p><p><strong>Methods: </strong>This study analyzed data on patients with lung cancer who underwent surgery in our department from July 2022 to December 2024.Patients were divided into training and validation sets.Logistic regression analysis was used to construct a column chart and identify predictive factors for cardiopulmonary complications.The chart's performance was evaluated using the C-index, the AUC, the calibration curve, and the decision curve analysis.The validation set was used for further model evaluation.</p><p><strong>Results: </strong>Multivariate logistic regression analysis demonstrated that smoking history, postoperative neutrophil count, postoperative systemic immunoinflammatory index (SII), ΔSII (change in SII), ΔPLR (change in platelet-lymphocyte ratio), and ΔAISI (change in neutrophil * platelet * monocyte/lymphocyte ratio) were predictive factors for postoperative cardiopulmonary complications. In the training set, the C-index of the model is 0.86 (95% confidence interval: 0.82-0.91), while in the validation set it is 0.81 (95% confidence interval: 0.73-0.89). The calibration curve demonstrates a strong correlation between the column chart model and the observed data. The decision curve analysis indicates that the net profit of this model is considerably superior to that of other models.</p><p><strong>Conclusion: </strong>The present study successfully developed and validated a predictive model based on systemic inflammatory markers to assess the risk of postoperative cardiopulmonary complications in patients with small cell lung cancer. This model assists clinicians in accurately assessing patients' risk of postoperative cardiovascular and pulmonary complications, thereby promoting personalized patient management.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8961-8976"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}