Journal of Inflammation Research最新文献

{"title":"Using Olink Proteomics to Identify Inflammatory Biomarkers in the Cerebrospinal Fluid in Guillain-Barré Syndrome.","authors":"Shuanghong Sun, Meng Li, Jihe Song, Di Zhong","doi":"10.2147/JIR.S507515","DOIUrl":"https://doi.org/10.2147/JIR.S507515","url":null,"abstract":"<p><strong>Purpose: </strong>The precise etiology of Guillain-Barré syndrome (GBS) is uncertain; however, it is linked to immunological and inflammatory processes. Thus, this research aims to investigate new inflammatory biomarkers for GBS diagnosis.</p><p><strong>Patients and methods: </strong>In this work, Olink proteomics was used to compare the expression levels of 92 inflammation-related proteins in the cerebrospinal fluid (CSF) of patients with non-inflammatory neurological diseases (n=14) and GBS (n=23). Differentially expressed proteins (DEPs) were then analyzed biologically and in terms of their relationship to clinical features, and logistic regression models were built. We also downloaded GEO data to validate DEPs at the mRNA level.</p><p><strong>Results: </strong>We identified twenty DEPs. The PPI network screened six key DEPs (including TNF, CCL20, IL8, MCP-1, IL10, and IL5). These DEPs were enriched in the chemokine signaling pathway, the IL-17 signaling pathway, cytokines and their receptor interactions, and other pathways. TNFRSF9 and IL-10RB showed the strongest correlation of expression in CSF. CCL20 and IL5 could be used as potential independent predictors for the diagnosis of GBS. Seven DEPs (MCP-1, CXCL1, MCP-4, MMP-10, CXCL10, CCL28, and CCL20) had some predictive value for the severity of GBS. Based on the validation of the GEO data, the mRNA expression of MCP-1 and CXCL9 was found to be upregulated at the peak of EAN, and the enriched pathways at the gene transcription level were consistent with the results of this study.</p><p><strong>Conclusion: </strong>DEPs linked to inflammation (such as TNF, CCL20, IL8, MCP-1, IL10, and IL5) could be useful biomarkers for GBS diagnosis. More research is required to determine their precise mechanisms in GBS.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6703-6717"},"PeriodicalIF":4.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis.","authors":"Yi Liu, Weili Zhao, Qingqing Huang, Linjun Wan, Zongfang Ren, Bangting Zhang, Chen Han, Jin Yang, Haoling Zhang, Jingjing Zhang","doi":"10.2147/JIR.S520726","DOIUrl":"https://doi.org/10.2147/JIR.S520726","url":null,"abstract":"<p><p>Sepsis, a lethal organ dysfunction syndrome driven by aberrant host responses to infection, intertwines excessive inflammatory responses and dysregulated coagulation processes in its pathophysiology. Emerging research reveals the complement terminal membrane attack complex C5b-9 orchestrates ultralarge von Willebrand factor (ULVWF) release from vascular endothelial cells (ECs) through multifaceted mechanisms: C5b-9 compromises EC membrane integrity, activates calcium influx cascades, and provokes NLRP3 inflammasome signaling, triggering massive exocytosis of ULVWF stored within Weibel-Palade bodies (WPBs). When ADAMTS13 activity falters, undegraded ULVWF complexes with platelets to spawn microthrombi, precipitating microvascular occlusion and multiorgan collapse. Strikingly, elevated plasma von Willebrand factor (vWF) antigen levels in sepsis patients correlate robustly with endothelial injury, thrombocytopenia, and mortality-underscoring C5b-9-driven vWF release as a linchpin of septic coagulopathy. Current therapeutic strategies targeting these pathways, including recombinant ADAMTS13 (rhADAMTS13), N-acetylcysteine (NAC), and complement inhibitors like eculizumab, face limitations in clinical translation, necessitating further validation of their efficacy. Additionally, investigating complement regulatory molecules such as CD59 may unlock novel therapeutic avenues. Deciphering the intricate interplay within the C5b-9-vWF axis and advancing precision therapies hold transformative potential for ameliorating sepsis outcomes.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6719-6733"},"PeriodicalIF":4.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MPO-ANCA-Associated Hypertrophic Pachymeningitis Mimicking IgG4-Related Disease: A Case Report and Literature Review.","authors":"Yuxue Chen, Lu Liu, Cuihong Xie","doi":"10.2147/JIR.S521138","DOIUrl":"https://doi.org/10.2147/JIR.S521138","url":null,"abstract":"<p><p>Hypertrophic pachymeningitis (HP) is a rare and chronic clinical disease characterized by thickening of the dura mater, leading to persistent headache, cranial neuropathy, seizures, and other neurological symptoms. Immune-mediated causes, particularly antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and IgG4-related disease (IgG4-RD), are among the most common etiologies. We report a case of a 54-year-old female with recurrent headache, blepharoptosis, hearing loss, and markedly elevated inflammatory markers. Blood tests, and serum levels of IgG4 were within normal ranges. Contrast enhanced cranial MRI revealed thickening and enhancement of bilateral cerebral hemispheres and tentorial dural maters. Additional findings included mild left lacrimal gland enlargement, bilateral middle ear mastoiditis, and tympanic tegmen destruction. Abdominal high-resolution computed tomography (CT) showed enlarged retroperitoneal lymph nodes. Histopathology demonstrated dense lymphoplasmacytic and neutrophilic infiltration with 80 IgG4-positive plasma cells per high-power field and an IgG4⁺/IgG⁺ cell ratio of 20%. An initial diagnosis of possible IgG4-RD was made. However, the patient's symptoms responded poorly to prednisolone (20 mg/day), and fever ensued. P<i>seudomonas aeruginosa, nocardia malleis</i>, and <i>leptocyclus virus</i> were found in the cerebrospinal fluid measured by NGS. Subsequent laboratory testing showed positive p-ANCA and anti-myeloperoxidase antibodies (anti-MPO), with a negative anti-nuclear antibodies panel, leading to a revised diagnosis of MPO-ANCA-associated HP. Treatment was escalated to intravenous methylprednisolone (40 mg/day), cyclophosphamide, and anti-infectious agents, leading to improved symptoms and decreased inflammatory markers. However, there was a recurrence during the taper of prednisolone. The addition of rituximab achieved complete remission. MPO-ANCA-associated HP is a rare inflammatory disorder that brings diagnostic challenges and requires comprehensive differential diagnosis. In relapsed or refractory cases, rituximab may be a valuable therapeutical option.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6673-6680"},"PeriodicalIF":4.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Precision Diagnosis: Thoughts and Suggestions on Enhancing the Nomogram for Ventilator-Associated Pneumonia [Response to Letter].","authors":"Jiajia Yang, Yuancheng Li, Ying Wang","doi":"10.2147/JIR.S537758","DOIUrl":"https://doi.org/10.2147/JIR.S537758","url":null,"abstract":"","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6681-6682"},"PeriodicalIF":4.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of CARD14-Associated Papulosquamous Eruption and Evaluation of Therapeutic Efficacy of Secukinumab.","authors":"Xinrong Zhao, Zhaoyang Wang, Yunliu Chen, Xin Xiang, Yuanxiang Liu, Chaoyang Miao, Zigang Xu","doi":"10.2147/JIR.S519554","DOIUrl":"10.2147/JIR.S519554","url":null,"abstract":"<p><strong>Background: </strong><i>CARD14</i>-associated papulosquamous eruption (CAPE) is a spectrum of disease exhibited by patients with <i>CARD14</i> mutations, which are rare and have a wide variety of clinical manifestations. Patients usually have limited response to traditional therapies.</p><p><strong>Methods: </strong>We retrospectively analyzed a case series of 8 patients with CAPE in China. Whole-exome sequencing (WES) was performed in all patients to identify the mutation type. Three patients received the treatment of secukinumab with a 52-week follow-up period. They achieved 84.6%, 76.9%, and 68.8% improvement in PASI score, respectively.</p><p><strong>Results: </strong>The study identified three new variants in <i>CARD14</i> that had not been previously reported: c.392_397del, c.391_392delinsTT, and c.-280C>T. Three patients with different clinical manifestations showed good response to secukinumab.</p><p><strong>Conclusion: </strong>The mutation types in <i>CARD14</i>-associated papulosquamous eruption were various. IL-17A inhibitors, such as secukinumab, can be an alternative treatment option for pediatric patients with CAPE.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6597-6605"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Systemic Immune Inflammation Index(Sll) and Outcome After Occlusion in Patients with Post-Infarction Ventricular Septal Rupture.","authors":"Qingwang Hou, Yipin Zhao, Zebin Lin, Tongfeng Chen, Xinlong Di, Xiaohu Wang, Jiangtao Cheng, Xiaoyan Guo, Chong Chen, Dan Hu, Chang Liu, Yapeng Jiang, Yancun Liu, Ying Li, Mai Su, Yuhao Liu","doi":"10.2147/JIR.S518540","DOIUrl":"https://doi.org/10.2147/JIR.S518540","url":null,"abstract":"<p><strong>Background: </strong>The Systemic Immune-Inflammation Index (SII) is a key indicator for assessing inflammatory status. This study aims to determine the association between SII and prognosis following occlusion in patients with post-infarction ventricular septal rupture (PIVSR).</p><p><strong>Methods: </strong>A total of 130 patients admitted to Fuwai Central China Cardiovascular Hospital between 2018 and 2023 were included in this retrospective study. Based on the tertiles of the Systemic Inflammatory Index (SII), the patients were categorized into two groups: 65 patients in the low SII group and 65 in the high SII group. Variable screening was performed using the Least Absolute Shrinkage and Selection Operator (LASSO) analysis. We conducted multivariable logistic regression analyses to rigorously assess the independent association between SII and short-term outcomes in PIVSR patients. After variable selection, a nomogram was constructed using R, and Restricted Cubic Splines (RCS) were employed to flexibly model nonlinear relationships. Subsequently, the predictive abilities of the screened variables and SII for the outcome were independently evaluated using Receiver Operating Characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>A nomogram model incorporating ALT, UREA, NT-proBNP, and SII was developed to predict the short-term prognosis of PIVSR patients following occlusion surgery. ROC curve analysis demonstrated that the area under the curve (AUC) for SII level was 0.702 (95% CI: 0.599-0.804, <i>P</i> < 0.001). Incorporating the Systemic Immune-Inflammation Index (SII) significantly improved prognostic accuracy, with Model 2 demonstrating superior discriminatory power (AUC 0.845 vs 0.828) over Model 1.</p><p><strong>Conclusion: </strong>The Systemic Immune-Inflammation (SII) is a convenient and effective prognostic indicator, and the model incorporating SII can facilitate personalized prognostic assessment for patients with post-infarction ventricular septal rupture (PIVSR).</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6641-6652"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of the Effects of Infrapatellar Fat Pad Excision on the Inflammatory Progression of Knee Osteoarthritis in Mice.","authors":"Ya Li, Peizhi Lu, Haoyu Yao, Shuo Yang, Bizhi Tu, Lingchao Kong, Rende Ning","doi":"10.2147/JIR.S517314","DOIUrl":"10.2147/JIR.S517314","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, and joint pain. The infrapatellar fat pad (IFP) has been suggested to play a role in modulating the inflammatory processes in KOA. Excision of the IFP is considered a potential therapeutic approach to reduce inflammation and slow disease progression.</p><p><strong>Methods: </strong>A mouse model of KOA was used to evaluate the impact of IFP excision on inflammation. Mice were divided into five groups: sham (control), unexcised IFP, quarter excision, partial excision, and complete excision of the IFP. Knee joints were collected at early, middle, and late stages of KOA. Gait analysis, micro-computed tomography (micro-CT), HE staining, Safranin O-Fast Green staining, and immunohistochemistry (IHC) were performed to assess joint stability, bone changes, and inflammatory markers (<i>MMP-3, IL-6, TNF-α, COL-2</i>). qRT-PCR was conducted for cartilage tissue analysis.</p><p><strong>Results: </strong>Partial IFP excision significantly improved joint stability, particularly in the middle and late stages of KOA. Micro-CT analysis showed increased bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) in excised groups, with the most significant effects in the partial and complete excision groups. IHC and qRT-PCR indicated reduced <i>MMP-3, IL-6</i>, and TNF-α levels in excised groups, particularly in the partial and complete excision groups, suggesting reduced inflammation. <i>COL-2</i> expression was higher in excised groups, particularly in late-stage KOA, indicating cartilage protection. The partial excision group exhibited the most balanced reduction in inflammation and improved cartilage integrity across all disease stages.</p><p><strong>Conclusion: </strong>IFP excision, especially partial excision, significantly modulates the inflammatory response in KOA. Partial excision showed the most effective and balanced impact on joint stability, bone integrity, and cartilage protection, offering potential as a therapeutic approach for KOA.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6653-6672"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Herb-Partitioned Moxibustion in the Angiogenesis of Colitis-Associated Cancer in Rats.","authors":"Kunshan Li, Luyi Wu, Lu Zhu, Wenjia Wang, Yiyi Chen, Zhe Ma, Guangtao Zhang, Muen Gu, Hanxiao Zhang, Huangan Wu","doi":"10.2147/JIR.S518214","DOIUrl":"https://doi.org/10.2147/JIR.S518214","url":null,"abstract":"<p><strong>Purpose: </strong>Angiogenesis in tumors is imperative to tumor growth. Our previous studies revealed that herb-partitioned moxibustion (HPM) could delay colitis-associated cancer (CAC), but the mechanism of the effects on the angiogenesis remains largely undiscovered. We aimed to investigate whether HPM delays CAC by inhibiting the angiogenesis with emergent three-dimensional (3D) imaging technologies.</p><p><strong>Materials and methods: </strong>The CAC model was induced by azoxymethane (AOM)/dextran sodium sulphate (DSS). The rats were randomly divided into normal, model and HPM groups. The tumorigenesis, number of tumors, and tumor diameter were observed. Immunohistochemistry or enzyme-linked immunosorbent assay (ELISA) was performed to assess the microvessel density (MVD), reactive oxygen species (ROS), hypoxia-inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor receptor 1 (VEGFR1), interleukin-6 (IL-6), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). The three-dimensional imaging of solvent-cleared organs with superior fluorescence-preserving capability (FDISCO) tissue clearing technique was used to clear colon tissues, and the platelet endothelial cells were stained and labelled with platelet endothelial cell adhesion molecule 1 (PECAM-1). Imaris software was used to perform 3D measurement and analysis of the colonic vascular architecture.</p><p><strong>Results: </strong>The HPM group were found decreased in the colon tumor diameter, MVD, ROS, HIF-1α, VEGFA, VEGFR1, IL-6, IL-1β, and TNF-α in colon tissues compared with those in the model group. 3D imaging revealed that the number of vessels, number of branch points, and vessel branch level in the HPM group were lower than those in the model group. The number of branch points and vessel branch level were negatively correlated with the average vessel length.</p><p><strong>Conclusion: </strong>HPM plays a role in inhibiting CAC angiogenesis. This study may provide new evidence at the macroscopic level of vascular architecture for HPM to inhibit the progression of CAC by FDISCO tissue clearing technique for 3D imaging.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6623-6639"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermedin_1-53 Improves Atherosclerosis by Reducing Local Endothelial Damage via AMPK Signaling Pathway in Obese apoE-Deficient Mice.","authors":"Han-Xu Zhu, Jin-Ling Ren, Wen-Juan Cao, Rui Wang, Lei-Lei Chen, Qing Gao, Ye-Bo Zhou","doi":"10.2147/JIR.S505695","DOIUrl":"https://doi.org/10.2147/JIR.S505695","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerotic cardiovascular diseases (CVD) are commonly found in obesity. Endothelial inflammation accompanied by oxidative stress is a crucial risk factor and a key initiating step for the pathogenesis of atherosclerosis (AS). In the present study, the role and mechanism of intermedin (IMD), a potent active peptide, in endothelial damage in AS in obese apolipoprotein E-deficient (apoE^-/-) mice were investigated.</p><p><strong>Methods and results: </strong>In vivo, IMD_1-53 was infused via Alzet mini-osmotic pump in apoE^-/- mice with high-fat diet (HFD) for 4 weeks. In vitro, palmitic acid (PA) and oxidized low density lipoprotein (Ox-LDL) were used to stimulate human umbilical vein endothelial cells (HUVECs) for exploring the potential mechanism of IMD_1-53 action on endothelial damage. We found that IMD_1-53 application remarkably improved plasma lipid profiles, hepatic lipid accumulation and its cholesterol levels, and vascular lipid accumulation and lesion sizes. Moreover, IMD_1-53 markedly increased eNOS expression and decreased the levels of vascular inflammatory factors and ROS. In vitro, the combination of PA and Ox-LDL caused more severe inflammatory and oxidative damages and lower expression of eNOS, which were significantly inhibited by IMD_1-53. IMD_1-53 notably induced AMPK phosphorylation, and the inhibition of AMPK activation markedly reversed the anti-inflammatory and antioxidant effects of IMD_1-53 on PA and Ox-LDL-treated HUVECs.</p><p><strong>Conclusion: </strong>IMD_1-53 improves AS partially by reducing endothelial inflammatory and oxidative damage via AMPK signaling pathway and decreasing vascular lipid accumulation involving the improvement of lipid profiles in blood and in liver in a state of obesity.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6583-6596"},"PeriodicalIF":4.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Composite Scoring System for Predicting Prognosis in Stage IV Gastric Cancer Patients Treated with Immune Checkpoint Inhibitors.","authors":"Lingbing Yang, Hongwei Li, Mingyu Xia, Xiaomeng Pu","doi":"10.2147/JIR.S519724","DOIUrl":"https://doi.org/10.2147/JIR.S519724","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) with distant metastases has a poor prognosis, and immune checkpoint inhibitors (ICIs) effectively improve the survival time of patients with this disease. This study aimed to identify effective prognostic markers that can predict the treatment effect of ICIs in patients with stage IV GC.</p><p><strong>Methods: </strong>This study included 256 patients with GC with distant metastases who had received treatment with ICIs. A receiver operating characteristic (ROC) curve was used to analyze the predictive ability and optimal cutoff values of immune-inflammatory markers. Kaplan‒Meier survival curves were used to analyze the differences in progression-free survival (PFS) and overall survival (OS) among patients. Cox proportional hazard regression analysis was used to identify independent prognostic factors for PFS and OS.</p><p><strong>Results: </strong>By comparing the area under the ROC curve (AUC) of immune-inflammatory markers, we selected the preoperative platelet count/(lymphocyte count × prealbumin count) ratio and fibrinogen/albumin ratio to form a combined score (PLPR-FAR score). The ROC curve revealed that when the PLPR-FAR score was used to predict patient PFS and OS, the AUC were 0.614 and 0.672, respectively. The Kaplan‒Meier survival curve revealed that patients with higher PLPR-FAR scores had significantly shorter PFS and OS than those with lower PLPR-FAR scores. Cox proportional hazard regression analysis revealed that the PLPR-FAR score was an independent risk factor for PFS and OS in stage IV GC patients.</p><p><strong>Conclusion: </strong>The PLPR-FAR score may help identify which patients are more likely to benefit from ICIs treatment, and could serve as a novel and promising prognostic biomarker.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6491-6504"},"PeriodicalIF":4.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}