Journal of Inflammation Research最新文献

{"title":"Prediction of Flares in Systemic Lupus Erythematosus During Post-Remission Follow-up.","authors":"Yu Bai, Jiuliang Zhao, Qian Wang, Dong Xu, Xiaofeng Zeng, Xinping Tian, He-Jun Li, Mengtao Li","doi":"10.2147/JIR.S504995","DOIUrl":"10.2147/JIR.S504995","url":null,"abstract":"<p><strong>Purpose: </strong>Patients at high risk of SLE flares benefit from being identified before flares; this can be done by predictors of flares. This study aimed to explore the predictive factors and model of SLE flares after remission, providing basis for clinical decision-making.</p><p><strong>Patients and methods: </strong>SLE patients recruited at the Peking Union Medical College Hospital (PUMCH), were all registered in the Chinese SLE treatment and research (CSTAR) registry cohort and had experienced at least one remission before December 31, 2020. Demographic, clinical, and laboratory parameters were collected through CSTAR online registry. The predictive effects of variables were analyzed using a Cox proportional hazards model. A nomogram was formulated to predict flares.</p><p><strong>Results: </strong>A total of 359 patients were included in the analysis, among which, 108 (30.1%) patients had at least one flare. Multivariate Cox regression model showed that younger age (hazard ratio [HR], 0.97; 95% CI, 0.95-0.99), positive anti-dsDNA at remission (HR, 1.64; 95% CI, 1.08-2.51), significantly low levels of C3 and C4 (HR, 2.09; 95% CI, 1.17-3.73) were independent risk factors associated with flares. A nomogram was established based on the multivariate analysis. The internal bootstrap resampling approach suggested the nomogram has a certain degree of discriminatory power with a C-index of 0.654 (95% CI, 0.601-0.707). The calibration plots also showed good consistency between the prediction and the observation.</p><p><strong>Conclusion: </strong>This study highlights that SLE patients with significantly low levels of C3 and C4, younger age, and elevated anti-dsDNA levels may require closer monitoring and follow-up after remission. Identifying these predictors allows clinicians to better assess the risk of flare and tailor therapeutic strategies accordingly for more effective long-term management.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3377-3384"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Hospitalized Immunocompromised Patients With COVID-19 and the Impact of Hyperinflammation: A Retrospective Cohort Study.","authors":"Xinxin Zhang, Xiaobo Han, Chenglong Li, Junchang Cui, Xin Yuan, Jiguang Meng, Zhihai Han, Xinjie Han, Wei Chen, Junchen Xiong, Wuxiang Xie, Lixin Xie","doi":"10.2147/JIR.S482940","DOIUrl":"10.2147/JIR.S482940","url":null,"abstract":"<p><strong>Purpose: </strong>Immunocompromised patients are at increased risk for severe outcomes from COVID-19 due to their altered immune responses, yet their inflammatory profiles and the interplay between immunosuppression remain poorly understood. We aimed to illustrate the inflammation profile and clinical outcomes of hospitalized immunocompromised patients with COVID-19.</p><p><strong>Methods: </strong>We conducted a retrospective study using a multicenter database and included adult hospitalized patients with Corona virus disease 2019 (COVID-19) in China's late 2022 COVID-19 wave. Crude and adjusted 28- and 60-day mortality was compared between the two groups. Inflammatory phenotypes were evaluated by serum interleukin-6 (IL-6) and C-reactive protein (CRP) level. The interplay between overt inflammation and immunosuppression was analyzed.</p><p><strong>Results: </strong>Among the 4078 included patients, 348 (8.5%) were immunocompromised. Immunocompromised patients had lower crude mortality but higher adjusted mortality at 28-day (hazard ratio [HR] = 1.55; 95% CI 1.08 to 2.23) and 60-day (HR = 1.47; 95% CI 1.05 to 2.06). Besides, immunocompromised patients had a higher risk of developing hyperinflammation (odd ratio [OR] =1.92; 95% CI 1.47 to 2.50, p <0.001). Moreover, hyperinflammation mediated a major part of the deleterious survival effect of immunosuppression on COVID-19.</p><p><strong>Conclusion: </strong>Immunodeficiency not only increases short-term mortality risk but also predisposes patients to hyperinflammation. The complex interplay between immunosuppression, hyperinflammation, and COVID-19 outcomes warrants more detailed profiling of inflammation and immunity in this population.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3385-3397"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of Pyroptosis in the Progression of Pulpitis and Apical Periodontitis.","authors":"Fan Gu, Delan Huang, Ruiqi Li, Linlin Peng, Tingting Huan, Kaili Ye, Zhuan Bian, Wei Yin","doi":"10.2147/JIR.S507198","DOIUrl":"10.2147/JIR.S507198","url":null,"abstract":"<p><p>Pyroptosis is a type of programmed cell death that induces proinflammatory cytokine release and is closely related to inflammatory diseases. Pulpitis and apical periodontitis are common inflammatory diseases that lead to alveolar bone destruction and tooth loss. Recent studies have revealed that pyroptosis is crucial in the progression of pulpitis and apical periodontitis, which involves various cell types and leads to different results. Odontoblasts are located at the periphery of dental pulp tissue and are susceptible to various irritants, the lysates from odontoblasts act as alerts and induce immune reactions in the inner pulp after pyroptosis. The expression levels of inflammasomes in dental pulp cells (DPCs) change with the progression of pulpitis, which may serve as a diagnostic marker of pulpitis. Periodontal ligament fibroblasts (PDLFs) undergo pyroptosis when stimulated by bacterial infection or cyclic stretch and are associated with both infection-induced and trauma-induced apical periodontitis. Immune cells can undergo pyroptosis directly after infection or are influenced by the pyroptotic secretome of other cells, which changes their composition. In this review, we briefly introduce the location and function of different cell types involved in the progression of pulpitis and apical periodontitis, summarize the roles of pyroptosis in different cells, and discuss the effects of drugs targeting pyroptosis in the treatment of pulpitis and apical periodontitis.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3361-3375"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative SII Can Predict Postoperative Recurrence and Serious Complications in Patients with Hepatolithiasis.","authors":"Tianyang Mao, Xin Zhao, Kangyi Jiang, Qingyun Xie, Manyu Yang, Hongyuan Wang, Peng Zheng, Zehua Lei, Fengwei Gao","doi":"10.2147/JIR.S506442","DOIUrl":"10.2147/JIR.S506442","url":null,"abstract":"<p><strong>Purpose: </strong>The occurrence and progression of hepatolithiasis are related to inflammatory reactions and immune proteins. This study aims to evaluate the relationship between systemic immune index (SII) in recurrence-free survival (RFS), as well as the incidence of severe postoperative complications in hepatolithiasis patients.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed 177 patients with hepatolithiasis. The optimal cut-off values of SII, systemic inflammatory response index (SIRI), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR) and prognostic nutritional index (PNI) were evaluated by the analysis of the receiver operating characteristic (ROC) curve. The relationship between SII, SIRI, NLR and clinical results was tested with <i>χ</i>²-test. Logical regression analysis is used to evaluate the risk factors of postoperative serious complications. The Kaplan-Meier survival curve and Cox regression analyses are used to evaluate the impact of SII, SIRI, NLR on RFS.</p><p><strong>Results: </strong>The analysis of the ROC curve determines the optimal cut-off value and the area under the curve (AUC) of SII, SIRI, NLR, MLR, PLR and PNI, and then grouped. In the multivariate analysis, surgical method (HR=3.331, 95% CI: 1.360-8.158, p=0.008) and SII (HR=2.883, 95% CI: 1.084-7.668, p=0.034) were identified as independent risk factors for serious postoperative complications; the multivariate cox regression analysis demonstrated that a history of gallstones (HR=1.965, 95% CI: 1.206-3.201, p=0.007), SII (HR=2.818, 95% CI: 1.340-5.926, p=0.006), and MLR (HR=3.240, 95% CI: 1.158-9.067, p=0.025) were independent risk factors for RFS; survival analysis results show that patients with low levels of SII (p<0.001), SIRI (p=0.005), and NLR (p<0.001) had significantly higher RFS compared to those in the high-level group.</p><p><strong>Conclusion: </strong>Preoperative high levels of SII, SIRI, and NLR are associated with postoperative recurrence in patients with hepatolithiasis, with SII identified as an independent risk factor for both postoperative RFS and serious complications.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3321-3331"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases - Opportunity or Challenge?","authors":"Jintao Fang, Weihan Zhu, Dian Yu, Lujian Zhu, Haorui Zha, Jingyi Tang, Yujia Li, Xiaxin Zhu, Ting Zhao, Wei Zhang","doi":"10.2147/JIR.S498703","DOIUrl":"10.2147/JIR.S498703","url":null,"abstract":"<p><p>Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation of Gasdermin proteins, which form membrane pores, leading to rapid cell rupture and the release of inflammatory molecules. Unlike other types of cell death, pyroptosis has distinct activation mechanisms and plays a complex role in chronic intestinal diseases, including inflammatory bowel disease, intestinal fibrosis, chronic infectious enteritis, and colorectal cancer. This review comprehensively examines how pyroptosis influences disease development and progression while exploring the therapeutic potential of targeting pyroptosis-related pathways. Moreover, the complex interplay between gut microbiota and pyroptosis is summarized, highlighting its critical role in the pathogenesis of chronic intestinal disorders. A deeper understanding of pyroptosis-related mechanisms in these diseases may provide valuable insights for future research and contribute to the development of innovative therapeutic strategies in gastroenterology.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3349-3360"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States.","authors":"Xiandu Jin, Yue Liu, Wenjun Jia, Ruohang Xu, Xiuju Guan, Min Cui, Hanmo Zhang, Hao Wu, Liping Wei, Xin Qi","doi":"10.2147/JIR.S507696","DOIUrl":"10.2147/JIR.S507696","url":null,"abstract":"<p><strong>Background: </strong>The systemic immune-inflammatory index (SII) serves as a comprehensive indication of systemic inflammation. However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated.</p><p><strong>Methods: </strong>A total of 2727 patients with CAD were enrolled between January 2018 and April 2022. SII was calculated as (platelet count × neutrophil count)/lymphocyte count. Participants were grouped by SII quartiles. Glucose metabolic status was classified as normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM) and diabetes mellitus (DM) according to World Health Organization guidelines. Logistic regression and restricted cubic spline models were applied to estimate the relationship between SII and severity of coronary artery lesions in different glucose metabolic states with further adjustments for confounders.</p><p><strong>Results: </strong>Logistic regression analysis indicated a significant association between SII and coronary lesion severity (<i>P</i> < 0.05). Regardless of glucose metabolic status, Participants in the highest SII quartile (Q4) had a markedly higher risk of severe coronary lesions than those in the lowest quartile (Q1). After adjusting for confounders, a significant association between SII and coronary lesion severity was observed in the Pre-DM and DM individuals (<i>P</i> < 0.05), whereas not in the NGR individuals (<i>P</i> > 0.05). Subgroup analyses revealed that the association between SII and coronary lesion severity was consistent across age, gender, hypertension, antihypertensive drugs, hyperlipidemia, antilipidemic drugs, smokingand drinking (<i>P</i> > 0.05). Furthermore, restricted cubic spline modeling indicated a significant linear correlation between SII and coronary artery lesion severity.</p><p><strong>Conclusion: </strong>The SII is a relatively stable indicator of inflammation and is positively correlated with coronary lesion severity. This study highlights the potential of SII as a novel inflammatory biomarker for assessing the coronary lesion severity among patients in different glucose metabolic states.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3295-3309"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Quantitative Evaluation of Proliferative Lupus Nephritis Based on Ultrasonic Viscoelastic Imaging.","authors":"Han Yuan, Yuanyuan Chen, Liyan Wei, Xinhong Liao, Yong Gao","doi":"10.2147/JIR.S505223","DOIUrl":"10.2147/JIR.S505223","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the role of ultrasonic viscoelastic imaging in predicting proliferative lupus nephritis (PLN).</p><p><strong>Methods: </strong>We prospectively used ultrasonic viscoelastic imaging to evaluate 143 patients with lupus nephritis (LN), who underwent kidney biopsies from May 2023 to June 2024. Sixty healthy volunteers served as the control group. Patients were categorized as 90 cases of PLN, and 53 cases of nonproliferative lupus nephritis (nPLN). Ultrasonic viscoelastic imaging was employed to quantitatively analyze kidney cortex elasticity (Emean), viscosity coefficient (Vmean) and dispersion coefficient (Dmean). Semi-quantitative assessment of the lesion tissues was conducted based on the activity index and chronic index scoring system established by the National Institutes of Health (NIH) in 2018. The relationship among clinicopathological, conventional ultrasound factors and viscoelastic parameters was evaluated.</p><p><strong>Results: </strong>Viscoelastic parameters (Emean, Vmean, and Dmean) significantly differed among the healthy control, PLN, and nPLN groups (all <i>p</i> < 0.05). The viscoelastic parameters (Emean, Vmean, and Dmean) of the PLN and nPLN groups exceeded those of the control group. Vmean and Dmean were considerably greater in the PLN group than in the nPLN group (<i>p</i> < 0.05). Vmean (OR 89.49, <i>p</i> = 0.002), serum creatinine (Scr) (OR 110.57, <i>p</i> = 0.024), and anti-dsDNA (OR 1.0, <i>p</i> = 0.015) were significant predictors of PLN. The combined model's area under curve (AUC) for predicting PLN was 0.83, better than any single indicator (<i>p</i> < 0.05). The peak systolic velocity (PSV) of the interlobar artery was determining factor of Emean (<i>p</i> < 0.05). The estimated glomerular filtration rate (eGFR), activity index, and body mass index (BMI) were determining factors of Dmean, while activity index was the determining factor of Vmean (<i>p</i> < 0.05). Correlation analysis reveals a positive correlation between Vmean and both the activity index and the chronicity index (<i>r</i> = 0.57 and <i>r</i> = 0.34, respectively, <i>p</i> < 0.05), as well as between Dmean and both the activity index and the chronicity index (<i>r</i> = 0.43 and <i>r</i> = 0.20, respectively, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>As a noninvasive examination method, ultrasonic viscoelastic imaging is beneficial for identifying PLN.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3269-3281"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-6089 Alleviates Inflammation and Cell Apoptosis Through Modulating the TLR4 Pathway in Mite-Sensitized Allergic Rhinitis.","authors":"Chang-Yu Qiu, Jia-Xin Bi, Xin-Yan Cui, Ruo-Xi Chen, Zheng Luan, Yun Guo, Mei-Ping Lu, Ling Li, Lei Cheng","doi":"10.2147/JIR.S497005","DOIUrl":"10.2147/JIR.S497005","url":null,"abstract":"<p><strong>Purpose: </strong>Allergic rhinitis (AR), a chronic inflammatory disease of nasal mucosa, is considered as a classic Th2-mediated disease. We aimed to elucidate the molecular mechanisms and therapeutic potential of microRNAs (miRNAs) in AR.</p><p><strong>Methods: </strong>Nasal mucosa was collected from patients with mite-sensitized AR and non-allergic controls for miRNA and mRNA sequencing. miRNA expression was profiled. GO and KEGG enrichment analyses were conducted. Luciferase reporter assay was implemented to identify potential targets of candidate miRNAs. An AR cell model was established through lipopolysaccharide (LPS) exposure. miR-6089 was overexpressed or downregulated to characterize its roles in the proliferation and apoptosis of human nasal epithelial cells (HNEpC). The relationship between miR-6089 and toll-like receptor 4 (TLR4) was described. PCR and ELISA were applied to quantify the expression levels of miRNAs and mRNAs.</p><p><strong>Results: </strong>A total of 28 miRNAs and 172 mRNAs were identified to be differently expressed in the nasal mucosa of patients with AR compared to controls. The KEGG enrichment analysis showed that TLR signaling pathway, NF-κB signaling pathway, IL-17 signaling pathway and other pathways were significantly enriched in these differentially expressed RNAs. As shown by PCR results, the expression of miR-6089 decreased, and that of TLR4, IL-6, IL-8, and TSLP increased significantly in the nasal mucosa from patients with AR. Dual-luciferase reporter assay showed that miR-6089 directly bound to TLR4. miR-6089 could increase the viability, inhibit apoptosis, and relieve inflammatory response in LPS-induced HNEpC. Furthermore, miR-6089 could regulate the expression of TLR4, IL-6, IL-8, and TSLP in the LPS-induced HNEpC.</p><p><strong>Conclusion: </strong>miR-6089 can alleviate LPS-induced inflammatory response via targeting TLR4 and may serve as a therapeutic target in the treatment of mite-sensitized AR.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3243-3254"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosine A2A Receptor Activation Alleviated Disease of Mice with Systemic <i>Candida albicans</i> Infection by Regulating Macrophage Function.","authors":"Xia-Nan Wu, Ke Dong, Yan Liu, Lan Yang, Jing Zhang, Ming Yang, Zhao-Wei Gao","doi":"10.2147/JIR.S501546","DOIUrl":"10.2147/JIR.S501546","url":null,"abstract":"<p><strong>Purpose: </strong>The incidence of candidemia, mediated by systemic <i>Candida albicans</i> (<i>C. albicans</i>) infection, was increasing. It is an urgent need to understand the underlying disease mechanisms to identify new therapeutic targets. This study aimed to investigate the roles of adenosine-adenosine receptor signal in systemic <i>C. albicans</i> infection.</p><p><strong>Methods: </strong>The candidemia mice models (named CA mice) were established by tail intravenous injection of <i>C. albicans</i>. CA Mice were treated with NECA (a metabolically stable adenosine analogue) or agonists targeting different adenosine receptors (A1R, A2AR, A2BR and A3R). The survival rate, renal fungal load and tissue damage were investigated. Bone marrow-derived macrophages (BMDM) were isolated and cultured to investigate the effects of NECA and adenosine receptor agonist on phagocytosis, killing function and polarization of macrophages.</p><p><strong>Results: </strong>In CA mice, we observed that NECA and A2AR agonist treatment significantly alleviated the sepsis score and increased the survival rate. Moreover, the renal injury and fungal load were reduced by NECA and A2AR agonist treatment. However, the other adenosine receptors (ie, A1R, A2BR and A3R) activation have no effect on survival and tissue damage of CA mice. A2AR activation could reduce macrophage infiltration in kidney and the production of inflammatory cytokine IL-6 in CA mice. Moreover, adenosine-A2AR signaling activation could enhance antifungal capacity of macrophages and promoted macrophage polarization toward the M2 subtype.</p><p><strong>Conclusion: </strong>Activation of adenosine-A2AR axis promoted macrophage M2 polarization, enhanced host defense against systemic <i>C. albicans</i> infection, and alleviated candidiasis. A2AR activation could be considered as a potential therapeutic strategy in candidemia.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3283-3294"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Rosacea Induced by Compound Vitamin Tablets: A Case Report.","authors":"Hui-Shang Feng, Wan-Tong Zhang, Zi-Ye Xi, Guo-Dong Hua, Chun-Miao Xue, Ling-Ling Li, Shuang-Qing Qu, Li-Li Zhao, Tai Zhang, Bao-Chen Zhu, Yuan-Wen Li","doi":"10.2147/JIR.S507861","DOIUrl":"10.2147/JIR.S507861","url":null,"abstract":"<p><p>We present a case of rosacea recurrence in a 37-year-old woman associated with the intake of compound vitamin tablets during the preconception period, with a Naranjo score of 7. These tablets, commonly used for nutritional supplementation to prevent anemia, contain a variety of vitamins, minerals, and trace elements. Despite their widespread use, reports of such supplements causing rosacea recurrence are rare. In this case, the patient experienced a recurrence of facial redness, stinging, and burning after taking the tablets on two separate occasions. Skin dermatoscopy, VISIA imaging, Clinician's Erythema Assessment (CEA), Investigator's Global Assessment (IGA), and Visual Analogue Scale (VAS) all confirmed the recurrence of rosacea. Given her intention to conceive, symptomatic treatment with emollient and reparative dressings was administered. The patient's symptoms gradually resolved after discontinuing the medication, with no recurrence observed during follow-up visits. Women with a history of rosacea should avoid these tablets during preconception, pregnancy, and lactation to prevent recurrence and should choose supplements carefully to minimize the risk of rosacea flare-ups.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"3311-3319"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}