Mechanisms and Factors Influencing Resorption of Herniated Part of Lumbar Disc Herniation: Comprehensive Review.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI:10.2147/JIR.S525233

Qilong Lai, Guanyi Gong, Yukai Lu, Peijie You, Yicheng Zhu, Zhiqiang Wang, Shun Lin, Hong Jiang, Xiaochun Li, Jintao Liu

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引用次数: 0

Abstract

Abstract: This review systematically examines the mechanisms underlying the spontaneous resorption of lumbar disc herniation (LDH), focusing on vascularization, autophagy, apoptosis, macrophage activity, and the therapeutic potential of traditional Chinese medicine (TCM). We emphasize that resorption is influenced by factors such as herniation type, disease duration, and imaging biomarkers (eg, the bull's-eye sign). Additionally, this review summarizes recent progress in the study of resorption mechanisms following lumbar disc herniation, providing a reference for future clinical research.

Methods: Literature was systematically searched in PubMed, Web of Science, and CNKI (2000-2024) using keywords: 'lumbar disc herniation,' 'resorption,' 'autophagy,' 'TCM.' Inclusion criteria: (1) human/animal studies; (2) MRI-confirmed LDH; (3) English/Chinese full texts. Exclusion criteria: case reports (n<10).

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影响腰椎间盘突出部分吸收的机制和因素：综合综述。

摘要：本文系统探讨了腰椎间盘突出症（LDH）自发吸收的机制，重点关注血管化、自噬、细胞凋亡、巨噬细胞活性以及中药的治疗潜力。我们强调，吸收受诸如疝类型、病程和成像生物标志物（如靶心征）等因素的影响。此外，本文综述了近年来腰椎间盘突出症后吸收机制的研究进展，为今后的临床研究提供参考。方法：系统检索PubMed、Web of Science、中国知网（CNKI） 2000-2024年间的相关文献，检索关键词为：腰椎间盘突出症、吸收、自噬、中医。纳入标准：(1)人类/动物研究；(2) mri证实的LDH；(3)中英文全文。排除标准：病例报告(n

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.