Journal of Inflammation Research最新文献

{"title":"Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways.","authors":"Mengyue Ren, Siman Li, Shaoqiang Li, Zhiwei Tan, Jun Shi","doi":"10.2147/JIR.S512868","DOIUrl":"10.2147/JIR.S512868","url":null,"abstract":"<p><strong>Objective: </strong>Allergic contact dermatitis (ACD) is a delayed-type inflammatory skin illness, and its incidence rate is 10-20%. Wenqing Yin (WQY) is a classic prescription commonly used to treat ACD in China and Japan, and this study aims to explore the pharmacological effect and therapeutic mechanism of WQY to treat ACD.</p><p><strong>Methods: </strong>The pharmacological effect of WQY were investigated using a mouse model caused by 2,4-dinitrofluorobenzene, and the Th1 and Th2 cells numbers in spleen were measured. The potential active components and signal pathways of WQY to treat ACD were obtained using UPLC-MS/MS and network pharmacological analysis, the protein expression levels in relation to the MAPK and JAK/STAT1 signaling pathways were assessed, and the serum metabolites were also analyzed.</p><p><strong>Results: </strong>WQY alleviated pathological injuries and reduced the increase in mast cells, reduced the thickness and weight of the ears, down-regulated the IL-6, IL-1β, IFN-γ, IL-4, T-bet, and STAT1 mRNA levels, and decreased the percentages of Th1 cells in spleen mononuclear cells of ACD mice. Meanwhile, 38 ingredients in WQY-containing serum were identified by UPLC<i>‒</i>MS/MS, and 123 overlapping target genes of WQY and ACD were then obtained. The analysis of GO and KEGG pathway enrichment of the 34 core target genes out of 123 revealed that WQY may effectively treat ACD by targeting specific biological processes, such as the MAPK and JAK-STAT signaling pathway. WQY decreased the <i>p</i>-JAK2, <i>p</i>-STAT1, <i>p</i>-ERK, <i>p</i>-JNK, and <i>p</i>-p38 expressions in the ears of ACD mice, which led to the inhibition of JAK2/STAT1 and MAPK signaling pathways in treatment of ACD.</p><p><strong>Conclusion: </strong>WQY exhibited a significant anti-inflammatory role on DNFB-induced ACD mice via inhibiting the Th1 immune response and IL-4 secretion, which may be closely linked to the JAK2/STAT1 and MAPK signaling pathways inhibition.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7013-7031"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease.","authors":"Yan Jiang, Yaqin Chen, Wen Lu, Yanchun Peng, Liangwan Chen, Yanjuan Lin","doi":"10.2147/JIR.S527868","DOIUrl":"10.2147/JIR.S527868","url":null,"abstract":"<p><strong>Background and objective: </strong>The Naples Prognostic Score (NPS) is a tool for assessing inflammation and nutrition, widely used in outcome evaluation. However, its association with adverse outcomes in patients with coronary artery disease (CAD) has not been explored. This study aims to investigate the prognostic value of NPS in CAD patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 2453 patients with CAD who visited the Fujian Heart Medical Center between 2017 and 2022. Patients were divided into three groups based on NPS. The NPS was calculated based on serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Univariate and multivariate regression analyses, along with Cox models, were used to assess the impact of NPS on adverse outcomes. Receiver operating characteristic (ROC) curves evaluated NPS's accuracy in predicting all-cause in-hospital mortality.</p><p><strong>Results: </strong>Patients with lower NPS scores are less likely to have comorbidities such as hyperlipidemia and chronic kidney disease. Additionally, they tend to use fewer medications for treatment. Multivariate analysis revealed that elevated NPS levels were independently associated with poorer clinical outcomes. Compared to group 1, the risk of all-cause mortality was significantly higher in groups 2 and 3 [group 2, adjusted odds ratio (aOR)=0.33; group 3, aOR=1.82; <i>P</i>=0.037], the risk of acute myocardial infarction was higher (group 2, aOR=2.41; group 3, aOR=4.05; <i>P</i><0.001), and the risk of stroke was also higher (group 2, aOR=1.26; group 3, aOR=1.80; <i>P</i>=0.039). ROC curve analysis showed that NPS could independently predict the risk of all-cause mortality in patients with CAD.</p><p><strong>Conclusion: </strong>This study suggests that the NPS, a novel metric integrating inflammation and nutritional status, is closely associated with the prognosis of CAD.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6999-7012"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between High-Sensitivity C-Reactive Protein and the Progression of Arteriosclerosis: The Kailuan Study.","authors":"Weizhe Li, Pei Liang, Xueliang Ma, Yanling Gao, Xiaoxin Bai, Shasha An, Xin Wang, Shuohua Chen, Shouling Wu","doi":"10.2147/JIR.S524495","DOIUrl":"10.2147/JIR.S524495","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.</p><p><strong>Methods: </strong>Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. Based on baseline hs-CRP levels, they were divided into three groups: hs-CRP <1 mg/L group, 1 mg/L≤hs-CRP≤3 mg/L group, and hs-CRP >3 mg/L group. Poisson regression analysis was employed for longitudinal comparison to assess the impact of different hs-CRP levels on baPWV≥1,400 cm/s.</p><p><strong>Results: </strong>(1) After a mean follow-up of 5.12 ± 2.84 years, the detection rates of baPWV≥1,400 cm/s at the end of follow-up were 28.54%, 33.36%, and 36.25% in the hs-CRP<1 mg/L (n=5,998), 1 mg/L≤ hs-CRP≤3 mg/L (n=4,101), and hs-CRP>3 mg/L (n=1,578) groups, respectively (<i>P</i><0.001). (2) Multivariable-adjusted Poisson regression analysis for baPWV≥1,400 cm/s showed that, after adjusting for confounding factors, compared to the hs-CRP<1 mg/L group, the 1 mg/L≤hs-CRP≤3 mg/L group had a 2.4% higher risk of arterial stiffness (RR: 1.024; 95% CI: 1.002 to 1.047; <i>P</i><0.05) and hs-CRP>3 mg/L group had a 6.3% higher risk (RR: 1.063; 95% CI: 1.031 to 1.095; <i>P</i><0.001). Sensitivity analysis validated the robustness of the results.</p><p><strong>Conclusion: </strong>Elevated hs-CRP is an independent risk factor for arteriosclerosis progression.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7047-7054"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Prediction of Post-Operative Systemic Inflammatory Response Syndrome Following Pediatric Percutaneous Nephrolithotripsy.","authors":"Nueraili Abudurexiti, Bide Liu, Shuheng Wang, Qiang Dong, Maimaitiaili Batuer, Zewei Liu, Xun Li","doi":"10.2147/JIR.S518631","DOIUrl":"10.2147/JIR.S518631","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and validate a machine learning-based model for predicting systemic inflammatory response syndrome (SIRS) in pediatric patients undergoing percutaneous nephrolithotripsy (PCNL) and to establish a prediction platform specifically tailored for this population.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from 410 pediatric patients who underwent PCNL at the People's Hospital of Xinjiang Uygur Autonomous Region between January 2013 and September 2024. The dataset was split into training and validation sets using a 7:3 ratio based on positive samples. The Synthetic Minority Over-sampling Technique (SMOTE) was applied to overcome class imbalance in the training set, while feature selection was performed using a combination of LASSO regression and Boruta algorithms. Eight advanced machine learning algorithms were employed to construct predictive models. The best-performing model was selected based on multiple performance metrics. Additionally, we validated an existing adult model to assess its effectiveness in the pediatric population and compared it with our model. Shapley Additive Explanations (SHAP) analysis was utilized to determine feature importance and model decision basis. Finally, we developed a prediction platform specifically for pediatric patients.</p><p><strong>Results: </strong>The postoperative SIRS incidence was 20.24%. The LightGBM algorithm demonstrated superior predictive performance, achieving an area under the curve (AUC) of 0.8576 and an F1 score of 0.6154. The existing adult models showed lower predictive accuracy in the pediatric cohort (AUC values of 0.7420 and 0.7053). Analysis of SHAP values indicated that operation time, stone burden, preoperative hemoglobin, preoperative monocyte count, and hydronephrosis were the five most critical features affecting predictions. We established a prediction platform specifically designed for the pediatric population.</p><p><strong>Conclusion: </strong>The LightGBM-based model effectively predicts postoperative SIRS in pediatric PCNL patients, providing a tailored tool for this population. The online prediction platform might be useful to guide clinical decision making.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7067-7081"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications.","authors":"Zhen Fan, Rui Chen, Xiaomei Xie, Zhifeng Chen, Dan Yang, Chunbo Hao, Shan Wang","doi":"10.2147/JIR.S505907","DOIUrl":"10.2147/JIR.S505907","url":null,"abstract":"<p><strong>Background and objective: </strong>Periodontitis is a chronic inflammatory condition that can be associated with systemic diseases like diabetes and cardiovascular disease. This study investigates the role of AIM2, a key inflammasome component, in periodontitis, focusing on its involvement in inflammation, DNA repair, and systemic disease links.</p><p><strong>Methods: </strong>AIM2 expression was analyzed in saliva and gingival crevicular fluid (GCF) from periodontitis patients. A mouse periodontitis model and in vitro gingival fibroblast experiments were used to study AIM2's role. Gene Set Enrichment Analysis (GSEA) and Protein-Protein Interaction (PPI) network analysis explored AIM2's systemic disease associations.</p><p><strong>Results: </strong>AIM2 was significantly upregulated in periodontitis patients and models, correlating with increased IL-1β, ASC, and Caspase-1. Immunofluorescence revealed AIM2's nuclear localization and co-localization with inflammatory markers. GSEA linked high AIM2 expression to cardiovascular diseases, while its suppression showed protective effects. PPI analysis identified interactions with DNA repair proteins (THOC2, SETX, ATM), suggesting a role in genomic stability and systemic disease.</p><p><strong>Conclusion: </strong>AIM2 drives local inflammation in periodontitis and may connect periodontitis to systemic diseases via DNA repair and systemic inflammation. This highlights AIM2 as a potential therapeutic target for managing periodontitis and associated systemic risks.</p><p><strong>Clinical significance: </strong>Targeting AIM2 could offer a dual therapeutic strategy to control periodontal inflammation and mitigate systemic disease risks, such as cardiovascular disorders.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6983-6997"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Seizure Outcomes in Antibody-Positive Autoimmune Limbic Encephalitis.","authors":"Hao Song, Sha Xu, Bing-Qing Du, Qi-Lun Lai, Meng-Ting Cai, Hong Li, Yin Hu, Yao Ding, Mei-Ping Ding, Yin-Xi Zhang, Chun-Hong Shen","doi":"10.2147/JIR.S521219","DOIUrl":"10.2147/JIR.S521219","url":null,"abstract":"<p><strong>Purpose: </strong>Autoimmune limbic encephalitis (ALE) often occurs with detectable neuronal antibodies, presenting with seizures as a prominent clinical manifestation. We aimed to investigate the clinical characteristics and seizure outcomes in a cohort with antibody-positive ALE.</p><p><strong>Methods: </strong>We consecutively recruited patients with antibody-positive ALE and new-onset seizures between July 2014 and February 2024. Their demographic, clinical, and paraclinical characteristics, and treatment were collected. Seizure outcomes during follow-up were evaluated respectively, as well as the associated risk factors.</p><p><strong>Results: </strong>Seventy-two patients were included, and the associated autoantibodies targeted the leucine-rich glioma-inactivated 1 (LGI1), gamma-aminobutyric acid type B receptor (GABA_BR), and glutamic acid decarboxylase 65 (GAD65). Secondarily generalized tonic-clonic seizures and focal non-motor seizures were the most prevalent seizure semiologies, and 28 (38.9%) patients exhibited multiple seizure types. Furthermore, among 54 patients with over two years of follow-up, 16 (29.6%) experienced intermittent seizures lasting for more than one year. Younger onset, specific antibodies, and multiple seizure types were correlated with the longer seizure duration (all <i>P</i> < 0.05). Six (11.1%) patients continued to have seizures even after two years of follow-up, comprising two with LGI1 and four with GAD65 antibodies. Female sex, younger onset, and specific antibody profiles were significantly associated with sustained seizures, indicating autoimmune-associated epilepsy (AAE, all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>In patients with antibody-positive ALE, seizure outcomes appeared to change over an extended follow-up period, particularly in those with LGI1 and GABA_BR antibodies. Younger age at disease onset, female sex, and specific antibody profiles may be indicators of AAE.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7055-7065"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8⁺ T Cells in the Progression of Androgenetic Alopecia.","authors":"Haijing Fu, Wumei Zhao, Leiwei Jiang, Shijun Shan","doi":"10.2147/JIR.S522458","DOIUrl":"10.2147/JIR.S522458","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Emerging evidence highlights inflammation as a critical mediator in follicular miniaturization and disease progression. This investigation systematically explores inflammatory mechanisms in AGA through comprehensive analysis of hair follicles transcriptional profiles combined with cellular heterogeneity.</p><p><strong>Methods: </strong>Matched follicular specimens were procured from AGA patients: occipital non-balding units (controls) versus frontal alopecic zones (experimental). Bulk RNA-sequencing was conducted on Norwood-Hamilton grade 3-5 AGA scalp tissues to delineate inflammatory signatures. Subsequent single-nucleus RNA sequencing (snRNA-seq) of grade 5 specimens resolved cellular heterogeneity. Immune subsets (NK/CD8⁺ T cells), vascular endothelia (BECs), keratinocytes, and fibroblasts were transcriptionally characterized. Findings were validated through immunofluorescence cytochemistry (IFC) and reverse transcription quantitative PCR (RT-qPCR).</p><p><strong>Results: </strong>Bulk RNA-sequencing of AGA hair follicles revealed heightened inflammatory signatures in grade 5 patients compared to grade 3-4 counterparts. To dissect cellular heterogeneity, we systematically investigated the dynamic changes of immune cells in hair follicles of AGA patients using snRNA-seq technology for the first time. The result showed that grade 5 AGA hair follicles, identifying significant enrichment of natural killer (NK) and CD8⁺ T cells in balding hair follicles. Concurrently, blood endothelial cells (BECs) in balding follicles exhibited downregulation of angiogenesis-related genes. Notably, IL-15-a cytokine critical for NK/CD8⁺ T cell proliferation-was overexpressed in BECs, keratinocytes, and fibroblasts, suggesting a microenvironmental cue for immune cell expansion.</p><p><strong>Conclusion: </strong>These findings collectively implicate NK and CD8⁺ T cell infiltration as drivers of inflammatory exacerbation in AGA. By blocking IL-15 signaling-mediated immune activation may be an innovative therapeutic approach to promote hair regeneration in AGA patients.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"7033-7046"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition.","authors":"Xiaoqiang Wang, Silong Gao, Daqian Zhou, Weiye Cai, Jiale Lv, Zhangchao Wei, Chao Song, Xubin Shan, Zongchao Liu","doi":"10.2147/JIR.S519179","DOIUrl":"10.2147/JIR.S519179","url":null,"abstract":"<p><strong>Background: </strong>Programmed cell death (PCD), including pyroptosis, apoptosis, and necroptosis, plays a critical role in the pathogenesis of intervertebral disc degeneration (IVDD). PANoptosis, a recently identified form of PCD integrating pyroptosis, apoptosis, and necroptosis, may represent a more comprehensive target for therapeutic intervention in IVDD.</p><p><strong>Objective: </strong>To explore the role of PANoptosis in IVDD and investigate the therapeutic potential and underlying mechanism of baicalin in regulating PANoptosis to alleviate disc degeneration.</p><p><strong>Methods: </strong>We performed integrative analyses of bulk transcriptomic datasets (GSE167199, GSE245147, GSE266883) and a single-cell RNA-seq dataset (GSE244889) to identify PANoptosis-related genes involved in IVDD. The expression and function of key genes were validated using clinical samples, an IL-1β-induced NPC degeneration model in vitro, and a puncture-induced rat IVDD model in vivo treated with baicalin.</p><p><strong>Results: </strong>Five core PANoptosis-related genes (FOS, CASP1, H1-2, BCL2L11, and H2AC6) were significantly upregulated in degenerated discs. Baicalin treatment effectively downregulated these genes at both mRNA and protein levels. Moreover, baicalin alleviated IL-1β-induced cell death in NPCs and improved histological features in the rat IVDD model.</p><p><strong>Conclusion: </strong>Our findings reveal a critical role of PANoptosis in IVDD progression and demonstrate that baicalin alleviates disc degeneration by inhibiting PANoptosis. This study provides novel insights into PANoptosis as a promising therapeutic target for IVDD.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6963-6981"},"PeriodicalIF":4.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Cellulitis of the Scalp Successfully Treated with a Combination of Ixekizumab and Tofacitinib.","authors":"Miaoqi Qiu, Xiaoyong Man, Jing Jing","doi":"10.2147/JIR.S504393","DOIUrl":"10.2147/JIR.S504393","url":null,"abstract":"<p><strong>Aim: </strong>Dissecting Cellulitis of the Scalp (DCS) is a rare form of neutrophilic primary cicatricial alopecia (PCA). It usually occurs in black males and is less commonly reported in Asian populations. There are no systematic treatment guidelines for this disease, the hypothetical co-pathogenesis of DCS and hidradenitis suppurativa (HS) has led to the fact that most of the current biological therapies for DCS are based on the experience of HS, such as biologics and JAK inhibitors. Both agents alone have been reported in the treatment of HS and DCS, but the efficacy is uncertain. For severely refractory DCS, the combination of biologics and Janus kinase inhibitors (JAKi) may be a new strategy. In this case, we describe a 28-year-old Chinese young man with a confirmed diagnosis of severe DCS who experienced nodules resolve and hair regrowth after a combination use of ixekizumab and tofacitinib. This is the first case of DCS treated with a combination of IL-17 inhibitors and JAKi.</p><p><strong>Purpose: </strong>We hope that dermatologists should be aware that early diagnosis of DCS and the application of biologics are essential to quickly control symptoms and prevent from PCA and keloids.</p><p><strong>Patients and methods: </strong>This is a patient from the Department of Dermatology, the Second Affiliated Hospital of Zhejiang University School of Medicine.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6959-6961"},"PeriodicalIF":4.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury.","authors":"Xue Sun, Yang Liu, Yan Liu, Shaozheng Ai, Pengli Luo","doi":"10.2147/JIR.S524046","DOIUrl":"10.2147/JIR.S524046","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aims to investigate specific changes in serological 5-MTP expression in sepsis-associated acute kidney injury (SA-AKI) patients and assess its potential as a biomarker for SA-AKI occurrence. Additionally, we seek to evaluate the predictive value of 5-MTP in long-term clinical prognosis following SA-AKI.</p><p><strong>Patients and methods: </strong>A prospective cohort study included 31 healthy controls and 78 patients diagnosed with sepsis at the Affiliated Hospital of Qinghai University. Following the collection of serological samples, 5-MTP levels were determined using targeted metabolomics.Additionally, we collected clinical data, including blood routine, biochemical, inflammatory indicators and severity of disease. Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis.</p><p><strong>Results: </strong>The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups(<i>P</i><0.05), and were associated with Scr, BUN, and eGFR levels(<i>P</i><0.05). Additionally, 5-MTP was identified as an independent influencing factor for all-cause mortality in patients with sepsis and SA-AKI. Higher levels of 5-MTP were linked to faster recovery of kidney function, while lower levels were associated with increased 90-day all-cause mortality in SA-AKI patients.</p><p><strong>Conclusion: </strong>5-MTP may have a protective role in the development of SA-AKI, and an early increase in serological expression of 5-MTP could positively impact the prognosis of sepsis and SA-AKI.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6865-6875"},"PeriodicalIF":4.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}