Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma. 辅助化疗在远端胆管癌中的作用。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-12 DOI: 10.1002/jhbp.12163

Yoon Soo Chae, Youngmin Han, Go-Won Choi, Younsoo Seo, Inhyuck Lee, Won-Gun Yun, Hye-Sol Jung, Wooil Kwon, Joon Seong Park, Jin-Young Jang

{"title":"Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma.","authors":"Yoon Soo Chae, Youngmin Han, Go-Won Choi, Younsoo Seo, Inhyuck Lee, Won-Gun Yun, Hye-Sol Jung, Wooil Kwon, Joon Seong Park, Jin-Young Jang","doi":"10.1002/jhbp.12163","DOIUrl":"https://doi.org/10.1002/jhbp.12163","url":null,"abstract":"Background: Recent studies addressing the role of adjuvant chemotherapy (AC) in cholangiocarcinoma (CCA) have been published; however, there are challenges in generalizing the findings due to different prognostic characteristics depending on tumor location and resectability. Therefore, this study aimed to investigate the role of AC in distal cholangiocarcinoma (dCCA), a common tumor subtype of CCA.Method: Data from 497 patients with dCCA who underwent curative surgery at Seoul National University Hospital between 2000 and 2019 were reviewed using prospectively collected clinicopathologic information.Results: The median overall survival (OS) and recurrence-free survival (RFS) in the entire cohort were 62.9 and 44.0 months, respectively. AC was associated with improved five-year OS (58.5% vs. 46.4%; p < 0.001) and RFS (49.9% vs. 40.7%; p = 0.005), particularly in patients with advanced T stages (≥ T3). Multivariate analysis revealed that AC was an independent positive prognostic factor for survival. Furthermore, adjuvant radiotherapy (RT) alone provides no survival benefit, whereas AC combined with RT (AC + RT) offers greater benefits, particularly for patients with positive resection margins.Conclusion: AC improved the postoperative survival outcomes of patients with dCCA who underwent curative surgery. Furthermore, AC + RT appears to provide greater benefits, especially for patients with positive resection margins.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply to the Letter to the Editor. 作者给编辑的回信。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-10 DOI: 10.1002/jhbp.12168

Dharmenaan Palamuthusingam, Camel M Hawley, Magid Fahim

引用次数: 0

New Endoscopic Strategy for Ampullary Tumor and Superficial Nonampullary Duodenal Epithelial Tumor Extending Into Papillary Area. 壶腹部肿瘤及扩展至乳头区十二指肠浅表性上皮肿瘤的内镜新策略。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-09 DOI: 10.1002/jhbp.12165

Takashi Hirose, Yoshihisa Takada, Kazuhiro Furukawa, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Masanao Nakamura, Hiroki Kawashima

{"title":"New Endoscopic Strategy for Ampullary Tumor and Superficial Nonampullary Duodenal Epithelial Tumor Extending Into Papillary Area.","authors":"Takashi Hirose, Yoshihisa Takada, Kazuhiro Furukawa, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Masanao Nakamura, Hiroki Kawashima","doi":"10.1002/jhbp.12165","DOIUrl":"https://doi.org/10.1002/jhbp.12165","url":null,"abstract":"Background and study aim: Endoscopic papillectomy (EP) is widely performed for avoiding high-risk surgeries. However, recurrence rates are high, and lateral extension is a risk for recurrence. With endoscopic submucosal dissection (ESD), even lesions with lateral extensions are able to be en bloc resected, and may reduce that risk. The aim of this study is to validate the adequacy and safety of the new strategy.Patients and methods: This is an exploratory observational study with prospective case enrollment and retrospective analysis.Inclusion criteria: patients aged 20-85 years with a diagnosis of ampullary tumor or superficial nonampullary duodenal epithelial tumors extending into papilla, and endoscopically resected between December 2020 and April 2023. EP was performed with a lateral extension of < 20 mm, and ESD was performed with 20 mm or more, and the validity of these strategies was verified.Results: In total, 40 patients were enrolled, 29 EP and 11 ESD underwent. The en bloc resection rate was 95% (38/40) and endoscopic control was 97.5% (39/40). Adverse events were observed in 27.5% (11/40), with no significant difference in both groups. No serious adverse event was observed.Conclusions: This strategy based on lateral extension performed very well, and ESD is a useful treatment.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propensity Score-Matched Comparison of Robotic and Laparoscopic Pancreaticoduodenectomy. 机器人胰十二指肠切除术与腹腔镜胰十二指肠切除术倾向评分匹配比较。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-09 DOI: 10.1002/jhbp.12161

Bor-Shiuan Shyr, Shin-E Wang, Shih-Chin Chen, Yi-Ming Shyr, Bor-Uei Shyr

{"title":"Propensity Score-Matched Comparison of Robotic and Laparoscopic Pancreaticoduodenectomy.","authors":"Bor-Shiuan Shyr, Shin-E Wang, Shih-Chin Chen, Yi-Ming Shyr, Bor-Uei Shyr","doi":"10.1002/jhbp.12161","DOIUrl":"https://doi.org/10.1002/jhbp.12161","url":null,"abstract":"Background: Robotic pancreaticoduodenectomy (RPD) has theoretical advantages over laparoscopic pancreaticoduodenectomy (LPD), offering enhanced dexterity with EndoWrist technology and improved ergonomics. This study aimed to compare surgical outcomes between RPD and LPD.Methods: Patients undergoing minimally invasive pancreaticoduodenectomy, including 679 RPD and 94 LPD, were included for comparison before and after propensity score matching (PSM).Results: After 1:1 PSM, 88 cases were analyzed in each group. The RPD group showed significantly shorter operation times (median: 7.5 vs. 11.0 h, p < 0.001). Complications were lower in the RPD group (46.6% vs. 65.9%, p = 0.010 overall; 9.1% vs. 19.3%, p = 0.010 for major complications with Clavien-Dindo ≥ III). Postoperative pancreatic fistula (POPF) was lower in the RPD group (3.4% vs. 12.5%, p = 0.026 for overall; 5.1% vs. 16.9%, p = 0.040 for soft parenchyma of pancreas; 4.1% vs. 16.7%, p = 0.042 for non-dilated pancreatic ducts). In the LPD group, all vascular resections required open conversion, whereas 42.9% of vascular resections were performed robotically in the RPD group (p = 0.013). There was no significant difference between RPD and LPD regarding intraoperative blood loss, conversion, vascular resection, surgical mortality, or survival outcomes.Conclusions: RPD offers several advantages over LPD, including shorter operation time, lower morbidity, and reduced incidence of major complications and POPF, especially in patients with soft pancreas and non-dilated pancreatic ducts.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Anatomical Variations of Right Hepatic Artery on Biliary Obstruction and Liver Fibrosis in Pediatric Congenital Biliary Dilatation Patients: A Retrospective Analysis of 1464 Cases. 1464例小儿先天性胆道扩张患者肝右动脉解剖变异对胆道梗阻及肝纤维化的影响

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-05 DOI: 10.1002/jhbp.12171

Jianfeng Luo, Kaikun Huang, Anxiao Ming, Haibin Wang, Yu Tian, Mei Diao, Long Li

{"title":"Impact of Anatomical Variations of Right Hepatic Artery on Biliary Obstruction and Liver Fibrosis in Pediatric Congenital Biliary Dilatation Patients: A Retrospective Analysis of 1464 Cases.","authors":"Jianfeng Luo, Kaikun Huang, Anxiao Ming, Haibin Wang, Yu Tian, Mei Diao, Long Li","doi":"10.1002/jhbp.12171","DOIUrl":"https://doi.org/10.1002/jhbp.12171","url":null,"abstract":"Background: The role of the ventrally positioned right hepatic artery (RHA) in congenital biliary dilatation (CBD) remains unclear.Methods: We retrospectively analyzed 1464 pediatric CBD patients undergoing surgery from 2015 to 2023, comparing those with ventrally positioned versus normal RHA.Results: Ventrally positioned RHA was identified in 10.31% of patients and was associated with more frequent symptoms (e.g., abdominal pain, vomiting, jaundice), elevated liver enzymes, and a higher incidence of liver fibrosis (23.40% vs. 14.85%, p = 0.008). It was an independent risk factor for fibrosis (adjusted OR = 1.74, p = 0.011) and correlated with increased bile duct strictures and intrahepatic duct dilation. No recurrence was observed during a 41-month median follow-up.Conclusions: Ventrally positioned RHA contributes to biliary obstruction and liver fibrosis in pediatric CBD. Early recognition and surgical correction may improve outcomes and reduce long-term complications.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed-Reality in Pancreatobiliary Endoscopy: Innovation Without Immediate Impact. 混合现实在胰胆管内窥镜：创新没有立即的影响。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-05 DOI: 10.1002/jhbp.12166

Muhammad Khubaib Iftikhar, Qurat Ul Ain Iftikhar, Bilal Tariq

引用次数: 0

Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis. 紧急ERCP对急性胆管炎并发急性胆石性胰腺炎临床结局的影响：倾向评分匹配分析

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-05 DOI: 10.1002/jhbp.12164

Mustafa Comoglu, Fatih Acehan, Enes Seyda Sahiner, Huseyin Camli, Zeki Mesut Yalin Kilic, Bulent Odemis, Ihsan Ates

{"title":"Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis.","authors":"Mustafa Comoglu, Fatih Acehan, Enes Seyda Sahiner, Huseyin Camli, Zeki Mesut Yalin Kilic, Bulent Odemis, Ihsan Ates","doi":"10.1002/jhbp.12164","DOIUrl":"https://doi.org/10.1002/jhbp.12164","url":null,"abstract":"Background/purpose: Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.Methods: A total of 144 patients diagnosed with AC concurrent with AGP between March 2019 and February 2024 were included in the study. Patients were classified into two groups: urgent ERCP group (ERCP ≤ 24 h) and non-urgent ERCP group (ERCP 24-72 h). Clinical outcomes were compared using propensity score matching (PSM) analysis.Results: After PSM, two well-balanced groups of 55 patients were created. The median ERCP time was 18 (13-21) hours in the urgent group and 41 (36-54) hours in the non-urgent group. There was no significant difference in composite outcomes, including in-hospital mortality, prolonged hospital stay, severe pancreatitis, or late localized/systemic complications of pancreatitis [11 (20%) vs. 16 (29.1%); p = 0.268]. Additionally, no significant difference was observed between the groups regarding prolonged hospital stay (p = 0.506), ICU admission (p = 0.680), or in-hospital mortality (p = 0.161).Conclusions: Urgent ERCP within 24 h does not significantly improve clinical outcomes compared to ERCP performed within 24-72 h in patients with AC and AGP.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply: "Prognostic Value of the Measurement at Admission of the Inferior Vena Cava in Acute Pancreatitis". 作者回复：“急性胰腺炎下腔静脉入院时测量的预后价值”。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-04 DOI: 10.1002/jhbp.12174

Augustin Meria, Thomas Chaigneau, Benoît Dupont

引用次数: 0

Precut Sphincterotomy is a Valuable Advanced Cannulation Technique for Difficult Biliary Duct Cannulation in Single-Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiopancreatography for Surgically Altered Anatomy. 预切括约肌切开术是单球囊肠镜辅助内镜逆行胆管造影术中胆管插管困难的一种有价值的先进插管技术。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-04 DOI: 10.1002/jhbp.12162

Masafumi Watanabe, Kosuke Okuwaki, Tomohisa Iwai, Mitsuhiro Kida, Hiroshi Imaizumi, Kai Adachi, Akihiro Tamaki, Taro Hanaoka, Chika Kusano

{"title":"Precut Sphincterotomy is a Valuable Advanced Cannulation Technique for Difficult Biliary Duct Cannulation in Single-Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiopancreatography for Surgically Altered Anatomy.","authors":"Masafumi Watanabe, Kosuke Okuwaki, Tomohisa Iwai, Mitsuhiro Kida, Hiroshi Imaizumi, Kai Adachi, Akihiro Tamaki, Taro Hanaoka, Chika Kusano","doi":"10.1002/jhbp.12162","DOIUrl":"https://doi.org/10.1002/jhbp.12162","url":null,"abstract":"Background: In single balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography (SBE-assisted ERCP) for patients with surgically altered anatomies, precut sphincterotomy is performed as an advanced cannulation technique for difficult biliary cannulation cases. This study evaluated the safety and efficacy of precut sphincterotomy.Methods: The study included patients who underwent SBE-assisted ERCP on a naive papilla with surgically altered anatomies (excluding Billroth-I reconstruction) from April 2015 to December 2023. The success rate of biliary cannulation and the complication incidence were analyzed retrospectively.Results: A total of 231 patients were included. Scope insertion to the duodenal papilla was possible in 204 cases (88.3%), and biliary cannulation was attempted in 198 cases (85.7%). Standard cannulation was successful in 132 cases (66.7%), while an additional 10 cases (5.1%) successfully cannulated using pancreatic guide wire-assisted biliary cannulation. An additional 28 cases (14.1%) were successfully cannulated using precut sphincterotomy. Therefore, the overall biliary cannulation success rate was 85.9% (170 of 198 cases). The success rate of precut sphincterotomy was 66.7% (28 of 42 cases). Intraoperative bleeding caused by precut sphincterotomy occurred in 11.9%, and other complications were present in 16.7% of cases.Conclusions: Precut sphincterotomy is a one of the valuable techniques in SBE-assisted ERCP for surgically altered anatomies.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor for "Operative and Nonoperative Management of Acute Cholecystitis in Patients on Chronic Kidney Replacement Therapy". 致“慢性肾脏替代疗法患者急性胆囊炎的手术与非手术治疗”编辑信。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-02 DOI: 10.1002/jhbp.12169

Renu Sah, Ankita Mathur, Venkata Dileep Kumar Veldi

引用次数: 0