Walid Hadji, Nassiba Beghdadi, Chady Salloum, Claire Goumard, Safi Dokmak, Chetana Lim, Stéphanie Roullet, Rania Bounab, Djillali Annane, Mickaël Lesurtel, Olivier Scatton, Daniel Cherqui, Marc Antoine Allard
{"title":"Incidence and Risk Factors of Symptomatic Venous Gas Embolism During Laparoscopic Liver Resection.","authors":"Walid Hadji, Nassiba Beghdadi, Chady Salloum, Claire Goumard, Safi Dokmak, Chetana Lim, Stéphanie Roullet, Rania Bounab, Djillali Annane, Mickaël Lesurtel, Olivier Scatton, Daniel Cherqui, Marc Antoine Allard","doi":"10.1002/jhbp.70013","DOIUrl":"https://doi.org/10.1002/jhbp.70013","url":null,"abstract":"<p><strong>Background: </strong>Risk factors of symptomatic venous gas embolism (GE) during laparoscopic liver resection (LLR) are poorly known. The objective of this study was to report the incidence, risk factors, and morbidity of symptomatic GE during LLR.</p><p><strong>Methods: </strong>All consecutive patients who underwent LLR in 3 French centers over 3 years were retrospectively studied. All intraoperative events, with a focus on symptomatic venous GE, were collected and reviewed.</p><p><strong>Results: </strong>Among the 518 LLR (507 patients) studied, 26 (5%) cases of symptomatic GE occurred. There was no GE-related death nor neurological sequelae after GE. The group of patients with GE and without GE was similar in terms of baseline characteristics, type of resection, and pneumoperitoneum pressure (≤ 12 mmHg in 93% of LLR) or intraoperative bleeding. Overall morbidity and length of stay were longer after GE. The probability of GE was higher under the Airseal insufflation system at 12 mmHg (7.1% with Airseal versus 0.59% with conventional systems, odds ratio 12.73, 95% confidence interval [2.66-228.4], p = 0.013).</p><p><strong>Conclusion: </strong>Our results suggest that AirSeal at 12 mmHg or more is a risk factor for symptomatic venous GE. Insufflation with lower pressure or alternative insufflation systems should be evaluated during LLR.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristics and Outcomes of Declined Adult Liver Allografts due to Donor-Related Medical Reasons in Japan: Insights for Safe Utilization.","authors":"Junya Mita, Yusuke Takemura, Juntaro Ashikari, Kaori Kuramitsu, Shohei Yoshiya, Takeo Toshima, Shinji Itoh, Hiroto Egawa, Tomoharu Yoshizumi, Hiroyuki Yokota","doi":"10.1002/jhbp.70015","DOIUrl":"https://doi.org/10.1002/jhbp.70015","url":null,"abstract":"<p><strong>Background: </strong>Few studies have evaluated allografts that were declined before the acceptance for deceased-donor liver transplantation. We aimed to elucidate the characteristics of these allografts and assess their transplantation outcomes.</p><p><strong>Methods: </strong>We analyzed data from 730 adult liver allografts transplanted between July 2010 and March 2024. Clinical characteristics of the transplanted allografts were evaluated according to the number of declines, and the outcomes of the recipients were analyzed.</p><p><strong>Results: </strong>Transplanted allografts were categorized into three groups: ≥ 5 declined (n = 41), 1-4 declined (n = 104), and no declined group (n = 585). The ≥ 5 declined group exhibited high liver enzyme levels and steatosis. Within this group, the Japan Risk Index and total ischemic time (TIT) were identified as poor prognostic factors. Notably, in cases where TIT exceeded 10 h, a poor prognosis was observed in the ≥ 5 declined group.</p><p><strong>Conclusion: </strong>Abnormal liver functions or steatosis were observed in the ≥ 5 declined group. Shortening the TIT could contribute to an improved prognosis after transplantation.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Factors and Strategies for Failure to Rescue Following Hepatectomy: A Review.","authors":"Jiro Kimura, Kosei Takagi, Tomokazu Fuji, Kazuya Yasui, Takeyoshi Nishiyama, Toshiyoshi Fujiwara","doi":"10.1002/jhbp.70014","DOIUrl":"https://doi.org/10.1002/jhbp.70014","url":null,"abstract":"<p><p>Failure to rescue (FTR), defined as mortality after major postoperative complications, is a crucial indicator of surgical quality. Although mortality rates after hepatectomy have declined owing to improved surgical techniques and perioperative care, FTR remains a major concern. This review synthesizes the current evidence on the risk factors contributing to FTR after hepatectomy and explores multidisciplinary strategies to reduce its rate. Post-hepatectomy liver failure, hemorrhage, bile leakage, and sepsis commonly precede FTR. Risk factors for FTR are multifactorial and include patient-, procedure-, and system-related factors. Higher procedural volumes are associated with lower FTR rates, likely due to better infrastructure, experienced personnel, and access to rapid interventions. Strategies to reduce the FTR rate include preoperative optimization, intraoperative precision, and vigilant postoperative surveillance. System-level approaches, such as multidisciplinary rounds, standardized escalation protocols, and a robust institutional safety culture, are also pivotal. Future innovations, such as predictive analytics, artificial intelligence, and wearable monitoring devices, offer considerable potential for the early detection of complications. Centralization of complex liver surgeries to high-volume centers is recommended to enhance team preparedness. This review emphasizes the importance of adopting a comprehensive, proactive, and technologically integrated approach to reduce the FTR rate after hepatectomy and improve patient survival.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Characteristics and Predictors of Acute Cholangitis With Enterococcal-Positive Bile Cultures: A Retrospective Study.","authors":"Junichi Kaneko, Masaki Takinami, Akihiro Anma, Daijiro Suzuki, Kohei Nishizawa, Yuichi Hirano, Tomoyuki Niwa, Atsushi Kato, Yurimi Takahashi, Masafumi Nishino","doi":"10.1002/jhbp.70012","DOIUrl":"https://doi.org/10.1002/jhbp.70012","url":null,"abstract":"<p><strong>Background: </strong>Enterococci are commonly isolated from bile cultures in patients with acute cholangitis (AC) and pose a global concern owing to antibiotic resistance. This study identified predictive factors and clinical characteristics of AC with enterococcal-positive bile cultures.</p><p><strong>Methods: </strong>Consecutive patients with AC and bactobilia who underwent endoscopic retrograde cholangiopancreatography between April 2022 and March 2024 were included. Patients were categorized into enterococcal (E) and non-E groups based on bile culture results. Predictive factors for enterococcal positivity were analyzed. Empirical antibiotic coverage and clinical outcomes (symptom duration, length of antibiotic therapy, in-hospital mortality, and short-term recurrence) were compared within all-grade and severe AC.</p><p><strong>Results: </strong>Among 250 patients, 100 with enterococcal-positive bile cultures formed the E group. Predictive factors included age > 71 years, immunosuppressed status, prior endoscopic sphincterotomy, and prior biliary stenting. Inappropriate empirical antibiotic coverage was more frequent in the E group across both severity categories. Clinical outcomes did not differ among all-grade patients except for higher short-term recurrence in the E group. No significant differences were observed among severe patients for any clinical outcome.</p><p><strong>Conclusions: </strong>Enterococcal-positive bile cultures are predicted by specific factors. Despite frequent inadequate empirical antibiotic coverage, most clinical outcomes were similar to those for non-enterococcal patients.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riccardo Pellegrini, Hiroyuki Ishida, Richard D Schulick, Marco Del Chiaro
{"title":"The Shifting Target: Redefining Timing and Risk in the Management of Mucinous Pancreatic Cysts.","authors":"Riccardo Pellegrini, Hiroyuki Ishida, Richard D Schulick, Marco Del Chiaro","doi":"10.1002/jhbp.70001","DOIUrl":"https://doi.org/10.1002/jhbp.70001","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eyad Ebrahim, Hochang Chae, Hyeong Seok Kim, So Jeong Yoon, Sang Hyun Shin, In Woong Han, Jin Seok Heo, Hongbeom Kim
{"title":"Natural History and Risk Factors of Splenic Infarction After Spleen-Preserving Distal Pancreatectomy Using the Warshaw Technique.","authors":"Eyad Ebrahim, Hochang Chae, Hyeong Seok Kim, So Jeong Yoon, Sang Hyun Shin, In Woong Han, Jin Seok Heo, Hongbeom Kim","doi":"10.1002/jhbp.70009","DOIUrl":"https://doi.org/10.1002/jhbp.70009","url":null,"abstract":"<p><strong>Background: </strong>The Warshaw technique for spleen-preserving distal pancreatectomy (SPDP), which sacrifices splenic vessels, is widely used for benign and borderline malignant pancreatic diseases due to its technical simplicity. However, it carries the risk of splenic infarction. This study aimed to evaluate the incidence, risk factors, and clinical course of splenic infarction in patients who underwent SPDP using the Warshaw technique.</p><p><strong>Methods: </strong>Patients who underwent SPDP using the Warshaw technique at the Samsung Medical Center between 2007 and 2022 were retrospectively analyzed. Postoperative computed tomography scans were reviewed by a single researcher to classify splenic infarction severity based on the extent of infarction.</p><p><strong>Results: </strong>About 158 patients underwent the Warshaw technique. Splenic infarction was observed in 75 patients (47.5%). Among these, 34 cases (21.5%) were classified as severe (> 50%) infarction. Univariate and multivariate analysis identified previous abdominal surgery as the only statistically significant risk factor. Among the 75 patients with splenic infarction, two required antibiotic management, while none required radiological intervention.</p><p><strong>Conclusion: </strong>Splenic infarction after SPDP using the Warshaw technique was clinically insignificant. These findings support the use of the Warshaw technique as a feasible and effective option for treating benign and borderline malignant pancreatic diseases.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to \"Novel Method to Prevent Severe Postoperative Pancreatic Fistula Caused by Lipolysis\".","authors":"","doi":"10.1002/jhbp.70010","DOIUrl":"https://doi.org/10.1002/jhbp.70010","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Systemic Lupus Erythematosus (SLE) on Short-Term Outcomes of Cholecystectomy for Acute Cholecystitis: An Analysis of the US National Readmission Database, 2016-2020.","authors":"Shao Ciao Luo, Kuei-Heng Chang, Te-Cheng Su, He-Yuan Hsieh, Yu-Hsuan Shih, Hsin-Chen Lin, Ming-Chih Chou","doi":"10.1002/jhbp.70004","DOIUrl":"https://doi.org/10.1002/jhbp.70004","url":null,"abstract":"<p><strong>Background/purpose: </strong>Systemic lupus erythematosus (SLE) may impact surgical outcomes of acute cholecystitis due to immune dysfunction and systemic inflammation. This study evaluated short-term outcomes of cholecystectomy in SLE patients using US Nationwide Readmissions Database data.</p><p><strong>Methods: </strong>Adults (≥ 18 years) admitted with acute cholecystitis who underwent cholecystectomy between 2016 and 2020 were included. Patients with cholecystostomy or missing data were excluded. After 1:4 propensity score matching, multivariable logistic regression assessed associations between SLE and postoperative outcomes, with results reported as adjusted odds ratios (aORs).</p><p><strong>Results: </strong>A total of 4400 patients were analyzed (880 with SLE; 3520 without). SLE was associated with higher odds of complications (aOR = 1.64, 95% CI: 1.30-2.08, p < 0.001), particularly sepsis (aOR = 2.41, 95% CI: 1.55-3.77, p < 0.001) and acute kidney injury (aOR = 1.64, 95% CI: 1.23-2.18, p = 0.001). SLE patients also had increased 30-day (aOR = 1.59, 95% CI: 1.24-2.03, p < 0.001) and 90-day (aOR = 1.61, 95% CI: 1.31-1.99, p < 0.001) readmission rates, longer hospital stays (β = 1.04 days), and higher costs (β = 13.01, 95% CI: 7.23-18.80, p < 0.001).</p><p><strong>Conclusions: </strong>SLE is independently linked to worse short-term outcomes following cholecystectomy for acute cholecystitis. Tailored perioperative strategies are warranted for this high-risk group.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takuya Maeda, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Hajime Asai, Ami Utsunomiya, Yui Murata, Yaohui Guo, Jiahui Liu
{"title":"Long-Term Outcomes of Congenital Biliary Dilatation Surgery: A Single-Center Study Highlighting the High Incidence of Complications Within 5 Years.","authors":"Takuya Maeda, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Hajime Asai, Ami Utsunomiya, Yui Murata, Yaohui Guo, Jiahui Liu","doi":"10.1002/jhbp.70011","DOIUrl":"https://doi.org/10.1002/jhbp.70011","url":null,"abstract":"<p><strong>Background: </strong>Congenital biliary dilatation (CBD) is a rare anomaly often treated surgically, yet postoperative complications remain a concern. This study aimed to evaluate the incidence, timing, and risk factors of such complications after CBD surgery.</p><p><strong>Methods: </strong>A retrospective review was conducted on 184 patients with CBD who underwent either open or laparoscopic surgery, with a mean follow-up of 9 years. The analysis focused on postoperative complications, including bile duct-related issues, pancreatic complications, and bowel obstruction.</p><p><strong>Results: </strong>Complications occurred in 14.7% of patients, predominantly bile duct-related (11.4%), followed by pancreatic (1.6%) and bowel obstruction (1.6%). Most bile duct complications, including anastomotic and intrahepatic strictures, emerged within 5 years postoperatively. Residual bile ducts were more common after open surgery, but no significant difference in other complications was observed between surgical approaches. No biliary malignancies developed during follow-up.</p><p><strong>Conclusion: </strong>The majority of complications occurred within 5 years after surgery, underscoring the importance of intensive monitoring during this period. Regular imaging and blood tests are essential for early detection. Although no malignancies were observed, long-term follow-up remains critical to address late-onset risks.</p><p><strong>Trial registration: </strong>Clinical registration number: 2023-045432262.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shorter Pancreatic Division-To-Anastomosis Time Reduces Drain Amylase Levels After Pancreatoduodenectomy for Nonpancreatic Cancer.","authors":"Shimpei Otsuka, Ryo Ashida, Katsuhisa Ohgi, Yoshiyasu Kato, Hideyuki Dei, Akifumi Notsu, Katsuhiko Uesaka, Teiichi Sugiura","doi":"10.1002/jhbp.70008","DOIUrl":"10.1002/jhbp.70008","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in surgical techniques, postoperative pancreatic fistula (POPF) remains a major concern after pancreatoduodenectomy (PD). Although various risk factors have been identified, most are patient-specific and nonmodifiable. This study investigated whether the time from pancreatic division to anastomosis (division-to-anastomosis time, DAT) influences postoperative outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed 182 patients who underwent PD for nonpancreatic cancer between 2017 and 2022. The relationship between DAT and drain amylase (D-amy) levels on postoperative day 3 was evaluated. We also investigated the association between DAT and POPF development. Multiple regression analyses were performed to adjust for potential confounding factors.</p><p><strong>Results: </strong>Median patient age was 72 years, and 64.8% were male. Primary diagnoses included distal bile duct (35.7%), ampullary (24.7%), and duodenal (7.7%) cancers. Longer DAT was independently associated with increased D-amy levels (regression coefficient 0.16, 95% confidence interval: 0.0-0.29), with each hourly increase in DAT corresponding to a 1.45-fold increase. Grade B POPF occurred in 48% of cases. Multivariate analysis identified prolonged DAT and higher BMI as independent POPF risk factors.</p><p><strong>Conclusions: </strong>Prolonged DAT during PD was associated with increased D-amy levels and POPF incidence. As a modifiable surgical factor, DAT represents a potential target for technical refinement to improve postoperative outcomes.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}