Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Prognostic significance of clinical scoring systems for large-duct primary sclerosing cholangitis in Japanese patients.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-27 DOI: 10.1002/jhbp.12117

Koji Takahashi, Ryosuke Horio, Hiroshi Ohyama, Motoyasu Kan, Mayu Ouchi, Hiroki Nagashima, Kohichiroh Okitsu, Izumi Ohno, Naoya Kato

{"title":"Prognostic significance of clinical scoring systems for large-duct primary sclerosing cholangitis in Japanese patients.","authors":"Koji Takahashi, Ryosuke Horio, Hiroshi Ohyama, Motoyasu Kan, Mayu Ouchi, Hiroki Nagashima, Kohichiroh Okitsu, Izumi Ohno, Naoya Kato","doi":"10.1002/jhbp.12117","DOIUrl":"https://doi.org/10.1002/jhbp.12117","url":null,"abstract":"Purpose: This study aimed to identify the significant factors associated with liver transplant-free survival time in Japanese patients with large-duct primary sclerosing cholangitis (PSC) by evaluating the association between various parameters and clinical scores at PSC diagnosis.Methods: This single-center retrospective study investigated factors influencing liver transplant-free survival in Japanese large-duct PSC patients. Univariate analysis using log-rank tests identified significant clinical parameters and scoring systems, which were further analyzed with multivariate Cox proportional hazards models to determine independent predictors of liver transplant-free survival.Results: A total of 77 patients with large-duct PSC were included. The univariate analysis identified that age (p < .001), serum albumin level (p = .024), Child-Pugh score (p = .0012), albumin-bilirubin score (p = .0083), Amsterdam-Oxford PSC score (p < .001), and revised Mayo risk score (p < .001) were significant predictors of liver transplant-free survival time. However, the multivariate analysis revealed that only the Amsterdam-Oxford PSC score remained as an independent factor significantly associated with liver transplant-free survival time (hazard ratio: 12.90, 95% confidence interval: 2.78-59.81, p = .0011).Conclusions: This study underscored the importance of utilizing the Amsterdam-Oxford PSC score in clinical practice to assess disease prognosis and guide patient management in Japanese patients with large-duct PSC.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of living donor liver transplantation for unresectable perihilar cholangiocarcinoma: A single center prospective study.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-25 DOI: 10.1002/jhbp.12121

Takashi Ito, Kojiro Taura, Ken Fukumitsu, Shinya Okumura, Satoshi Ogiso, Takayuki Anazawa, Kazuyuki Nagai, Yoichiro Uchida, Takamichi Ishii, Etsuro Hatano

{"title":"Safety and efficacy of living donor liver transplantation for unresectable perihilar cholangiocarcinoma: A single center prospective study.","authors":"Takashi Ito, Kojiro Taura, Ken Fukumitsu, Shinya Okumura, Satoshi Ogiso, Takayuki Anazawa, Kazuyuki Nagai, Yoichiro Uchida, Takamichi Ishii, Etsuro Hatano","doi":"10.1002/jhbp.12121","DOIUrl":"https://doi.org/10.1002/jhbp.12121","url":null,"abstract":"Background: The prognosis for unresectable perihilar cholangiocarcinoma (phCCA) is extremely poor. Liver transplantation in combination with neoadjuvant chemoradiation therapy has become the treatment of choice for unresectable phCCA in the USA. In 2018, we launched a prospective study to evaluate the safety and efficacy of living donor liver transplantation (LDLT) for unresectable phCCA.Methods: A total of 10 patients were enrolled in this study between 2018 and 2024. Finally, five patients with unresectable phCCA underwent LDLT after neoadjuvant chemotherapy, radiation, and staging laparotomy, while the other five patients dropped out of the protocol.Results: The median follow-up period was 23.7 months. The overall survival rate for the five patients who underwent LDLT was 100% after one year. Hepatic artery thrombosis and delayed gastric emptying occurred in two and three cases, respectively. The histological efficacy of preoperative treatment was grade IIb and III, according to the Evans classification, in all five patients. All surgical margins and dissected lymph nodes were negative. Four patients were alive with no evidence of disease recurrence while one patient had recurrence 10 months after LDLT.Conclusions: LDLT is feasible and may be a last-resort treatment option for unresectable phCCA, although the long-term outcomes need to be carefully monitored.Clinical trial register and clinical registration number: The UMIN registration number for this study is 000033348.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyses of CTNNB1 mutation and expression and clinicopathological characteristics in 179 cases of solid-pseudopapillary neoplasm of the pancreas.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-24 DOI: 10.1002/jhbp.12123

Shuai Zhao, Jian Wang, Huimin Liu, Shasha Liu, Lin Sun, Ying Wang, Song Gao, Yan Sun

{"title":"Analyses of CTNNB1 mutation and expression and clinicopathological characteristics in 179 cases of solid-pseudopapillary neoplasm of the pancreas.","authors":"Shuai Zhao, Jian Wang, Huimin Liu, Shasha Liu, Lin Sun, Ying Wang, Song Gao, Yan Sun","doi":"10.1002/jhbp.12123","DOIUrl":"https://doi.org/10.1002/jhbp.12123","url":null,"abstract":"Background: Nuclear expression of CTNNB1 is occasionally negative in solid-pseudopapillary neoplasm (SPN) of the pancreas, leading to a missed diagnosis. In the present study, we aimed to investigate the clinical significance of CTNNB1 mutation detection for diagnosing SPN and explore the difference in clinicopathological characteristics at different ages and sex.Methods: Patients who underwent surgery for a pathologically confirmed SPN in our institution between 2011 and 2020 were collected. Their clinicopathological data were analyzed.Results: The median age of the 179 patients was 31 years (6-64 years), including 34 pediatric patients (19.0%), and 32 patients were male (17.9%). We detected point mutations in exon 3 of CTNNB1 in 74.3% (133/179) of SPNs by Sanger sequencing. The main mutation sites were D32, S33, S37, G34 and T41. In the three SPNs without nuclear expression of CTNNB1, Sanger sequencing showed point mutations of CTNNB1. NGS did not detect any consistent mutation except CTNNB1 in the three cases. The tumor size, Ki-67 index, and the negative rates of CTNNB1 nuclear expression and synaptophysin expression in the pediatric group were higher than those in other groups (p < .05).Conclusions: For atypical cases, testing for CTNNB1 mutations can help in the accurate diagnosis of SPN. Compared with adult patients, pediatrics with SPN may be more prone to recurrence, and their immunohistochemical phenotype is more complex, requiring additional care in the diagnosis and postoperative follow-up.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A left-posterior approach to the superior mesenteric artery during robot-assisted pancreaticoduodenectomy.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-21 DOI: 10.1002/jhbp.12120

Sho Kiritani, Yosuke Inoue, Takafumi Sato, Yui Sawa, Kosuke Kobayashi, Atsushi Oba, Yoshihiro Ono, Hiromichi Ito, Yu Takahashi

{"title":"A left-posterior approach to the superior mesenteric artery during robot-assisted pancreaticoduodenectomy.","authors":"Sho Kiritani, Yosuke Inoue, Takafumi Sato, Yui Sawa, Kosuke Kobayashi, Atsushi Oba, Yoshihiro Ono, Hiromichi Ito, Yu Takahashi","doi":"10.1002/jhbp.12120","DOIUrl":"https://doi.org/10.1002/jhbp.12120","url":null,"abstract":"Background: A complete dissection around the superior mesenteric artery (SMA) with artery-first concept is crucial during pancreaticoduodenectomy for periampullary cancers. The left-posterior (LP) approach to the SMA may be effective during robot-assisted pancreaticoduodenectomy (RPD), but data on its technical feasibility and clinical outcomes are limited.Methods: We retrospectively reviewed 83 RPD patients utilizing the LP approach, dividing them into early (n = 42) and late (n = 41) groups to assess procedural maturity. The LP approach was initiated at the first phase of resection to achieve circumferential SMA dissection from the left and posterior aspect and early vascular control through ligation of the inferior pancreaticoduodenal artery (IPDA). Postoperative short-term outcomes were compared between the two groups.Results: The late group demonstrated significantly shorter operative times (518 vs. 626 min; p < .01) and higher rates of IPDA ligation (90% vs. 71%; p = .03). The median blood loss in the late group was 50 mL (65 mL in the early group; p = .39). Lymph node retrieval number was 17 in both (p = .81), and R0 resection was achieved in all late group cases (96% in the early group; p = .35).Conclusions: With experience from approximately 80 cases, the LP approach for RPD has enabled precise SMA dissection and early vascular control. A stable and super-magnified caudal view provided by robotic surgery is particularly advantageous for this approach.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living-donor liver transplantation using donors older than 50 years of age: Recipient criteria and donor risk: A multicenter study of Japanese Society of Hepato-Biliary-Pancreatic Surgery.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-18 DOI: 10.1002/jhbp.12118

Takeo Toshima, Tomoharu Yoshizumi, Yasutsugu Takada, Takashi Ito, Masahiro Shinoda, Takeshi Takahara, Keinosuke Ishido, Hiroyuki Takamura, Akinobu Taketomi, Naokazu Chiba, Masafumi Nakamura, Ken Shirabe, Itaru Endo

{"title":"Living-donor liver transplantation using donors older than 50 years of age: Recipient criteria and donor risk: A multicenter study of Japanese Society of Hepato-Biliary-Pancreatic Surgery.","authors":"Takeo Toshima, Tomoharu Yoshizumi, Yasutsugu Takada, Takashi Ito, Masahiro Shinoda, Takeshi Takahara, Keinosuke Ishido, Hiroyuki Takamura, Akinobu Taketomi, Naokazu Chiba, Masafumi Nakamura, Ken Shirabe, Itaru Endo","doi":"10.1002/jhbp.12118","DOIUrl":"https://doi.org/10.1002/jhbp.12118","url":null,"abstract":"Background: Few published reports have addressed the feasibility of living-donor liver transplantation (LDLT) using elderly donors. We aimed to examine LDLT outcomes in elderly donors and identify clinical factors impacting safely conducted LDLT.Methods: This study was conducted in collaboration with the Japanese Society of Hepatobiliary-Pancreatic Surgery. Data were collected from 140 patients who underwent LDLT using donors aged ≥50 years between 2013 and 2017 at nine collaborating hospitals.Results: The 1-, 3-, and 5-year graft survival rates in recipients after LDLT employing elderly donors were 84.3%, 78.5%, and 76.3%, respectively, with 6-month mortality of 12.1%. Specific recipient-donor age combinations did not emerge as adverse prognostic factors. A total of 32 recipients (22.9%) had major complications requiring reoperation after LDLT, and 15 donors (10.7%) had major complications of Clavien-Dindo grade ≥II. Multivariate analysis revealed that graft-to-recipient weight ratio (GRWR) <0.84% and neutrophil-to-lymphocyte ratio (NLR) >6.6 were independent predictors of 6-month graft loss after LDLT.Conclusion: LDLT using elderly donors aged ≥50 years has acceptable graft survival and morbidity rates, and donor age >50 years should not be an absolute contraindication for LDLT. In LDLT involving elderly donors, it is crucial to consider that GRWR <0.84% and NLR >6.6 are adverse prognostic factors. Addressing these factors is necessary to enhance the prognosis, aligning with the increasing public demand for this surgical procedure.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of needle tract seeding following endoscopic ultrasound-guided tissue acquisition for cholangiocarcinoma.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-17 DOI: 10.1002/jhbp.12124

Tatsunori Satoh, Haruna Takahashi, Shinya Kawaguchi

引用次数: 0

The impact of extra-pancreatic infections on outcomes of acute pancreatitis: A systematic review and meta-analysis.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-14 DOI: 10.1002/jhbp.12099

XueMin Zhang, Ping Zhu, YanFei Zhang, ShanShan Dai

{"title":"The impact of extra-pancreatic infections on outcomes of acute pancreatitis: A systematic review and meta-analysis.","authors":"XueMin Zhang, Ping Zhu, YanFei Zhang, ShanShan Dai","doi":"10.1002/jhbp.12099","DOIUrl":"https://doi.org/10.1002/jhbp.12099","url":null,"abstract":"Background: The impact of extrapancreatic infections (EPI) on outcomes of acute pancreatitis has received limited attention in the literature. We compiled data from published studies to present high-quality evidence on the prognostic role of EPI on acute pancreatitis.Methods: This PRISMA-compliant and PROSPERO registered review (CRD42024516872) searched Embase, Scopus, Web of Science, and PubMed for comparative studies between EPI and no-EPI. Outcomes assessed were mortality, intensive care unit (ICU) admission, necrosis, organ failure, persistent organ failure, and length of hospital stay (LOS).Results: Seven studies were included in the review. The meta-analysis found that patients with EPI had a significantly higher risk of mortality as compared to the no-EPI group (OR: 3.85 95% CI: 2.79, 5.31). The risk of ICU admission (OR: 12.24 95% CI: 3.56, 42.10), necrosis (OR: 3.50 95% CI: 1.37, 8.89) organ failure (OR: 6.03 95% CI: 3.75, 9.70) and persistent organ failure (OR: 6.72 95% CI: 3.58, 12.62) was significantly increased in the EPI group compared to the non-EPI group. The meta-analysis also found significantly longer LOS in the EPI group (MD: 11.92 95% CI: 4.75, 19.08).Conclusion: EPI is associated with a worse prognosis in acute pancreatitis. EPI was associated with an increased risk of mortality, ICU admission, organ failure, and prolonged LOS. Limited number of studies and baseline confounding are drawbacks of current evidence which need to be rectified by future studies.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-13 DOI: 10.1002/jhbp.12111

Takashi Kokumai, Shuichi Aoki, Kei Nakagawa, Masahiro Iseki, Hideaki Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno

{"title":"High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.","authors":"Takashi Kokumai, Shuichi Aoki, Kei Nakagawa, Masahiro Iseki, Hideaki Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno","doi":"10.1002/jhbp.12111","DOIUrl":"https://doi.org/10.1002/jhbp.12111","url":null,"abstract":"Background: Hemihepatectomy with extrahepatic bile duct resection is considered the only curative treatment for perihilar cholangiocarcinoma. The aim of the study was to clarify the survival benefits in this invasive surgical procedure for elderly patients.Methods: A total of 290 patients who underwent surgical resection for perihilar cholangiocarcinoma in our department from 2000 to 2020 were categorized into the E group (62 patients aged ≥75 years) and NE group (228 patients aged <74 years).Results: The E group exhibited decreased pathological lymph node metastasis (p = .001) and had a shorter operative time (p = .021) and fewer cases of combined vascular resection (p = .002). We found no significant differences in postoperative mortality; however, disease-specific survival was significantly better in the E group (3-year survival: 75.6 vs. 60.3%, p = .031). After propensity score matching, overall survival and disease-specific survival did not differ between the two groups; nevertheless, the hospital mortality rate was significantly higher in the E group (11.5 vs. 1.6%, p = .020). In the E group, a high preoperative Glasgow prognostic score was the only factor associated with hospital mortality (odds ratio, 7.35; p = .026) and indicated worse prognosis.Conclusions: A high preoperative Glasgow prognostic score was associated with hospital mortality and poor prognosis in elderly patients with perihilar cholangiocarcinoma.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholangiogram of durvalumab-related sclerosing cholangitis as immune-mediated adverse event.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-12 DOI: 10.1002/jhbp.12119

Naosuke Kuraoka, Tetsuro Ujihara, Shun Sakai

引用次数: 0

Intraprocedural mixed-reality hologram support in endoscopic retrograde cholangiography (ERC) for bile leaks.

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-02-12 DOI: 10.1002/jhbp.12098

Hirohito Minami, Kazumasa Nagai, Maki Sugimoto, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Hiroyuki Kojima, Takao Itoi

引用次数: 0