Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

{"title":"A Structured Preoperative Imaging Checklist for Pancreatoduodenectomy: Translating Precision Anatomy Into Surgical Practice","authors":"Pasquale Avella, Martina Guerra, Aldo Rocca","doi":"10.1002/jhbp.70141","DOIUrl":"10.1002/jhbp.70141","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"e86-e88"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial Pancreatic Cancer at a Tertiary Referral Center: Incidence and Clinical Characteristics in Korea","authors":"Eugene Park,&nbsp;Hochang Chae,&nbsp;Hyeong Seok Kim,&nbsp;Sang Hyun Shin,&nbsp;In Woong Han,&nbsp;Jin Seok Heo,&nbsp;Hongbeom Kim","doi":"10.1002/jhbp.70142","DOIUrl":"10.1002/jhbp.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Familial pancreatic cancer (FPC), defined as kindreds with at least two first-degree relatives affected by pancreatic cancer (PC), represents a high-risk subgroup. However, data on its incidence and clinical characteristics in Korea remain limited. This study evaluated the incidence, clinicopathologic features, and prognostic impact of FPC at a tertiary referral center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 5 858 patients diagnosed with pancreatic ductal adenocarcinoma between 2008 and 2019. FPC was defined as at least one pair of first-degree relatives with PC. Clinicopathologic characteristics and overall survival (OS) were compared between FPC and non-FPC groups. Propensity score matching (PSM) was performed using age, sex, and clinical stage. Survival was assessed using Kaplan–Meier analysis and Cox regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FPC was identified in 208 patients (3.55%) and in 5.0% of those undergoing curative-intent surgery (1 536 patients). Before PSM, FPC patients were less likely to present with metastatic disease and more likely to receive surgery and chemotherapy. After PSM, differences were not significant. OS was comparable between FPC and non-FPC groups, and FPC was not an independent prognostic factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this large Korean cohort, FPC incidence and survival outcomes were comparable to those of non-FPC cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"779-788"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Alcohol Consumption Before Hepatocellular Carcinoma Resection: From Prognostic Marker to Modifiable Addiction-Related Risk Factor","authors":"Iok-Hong Tan,&nbsp;Lien-Chung Wei","doi":"10.1002/jhbp.70151","DOIUrl":"10.1002/jhbp.70151","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"e90-e91"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel, Small-Incision, Gasless Videoscope-Assisted Necrosectomy for Infected Walled-Off Necrosis: A Single-Center Experience","authors":"Hideki Sasanuma,&nbsp;Naohiro Sata,&nbsp;Masatake Taniguchi,&nbsp;Yuichi Aoki,&nbsp;Masanobu Taguchi,&nbsp;Yoshiyuki Meguro,&nbsp;Naoya Kasahara,&nbsp;Kazue Morishima,&nbsp;Yasunaru Sakuma,&nbsp;Hironori Yamaguchi","doi":"10.1002/jhbp.70137","DOIUrl":"10.1002/jhbp.70137","url":null,"abstract":"<p>When endoscopic drainage is challenging for infected walled-off necrosis with solid-predominant debris, gasless videoscope-assisted necrosectomy (VANE) offers a complementary surgical step-up option. With accompanying video, Sasanuma and colleagues demonstrate how its wide-bore corridor enables effective, single-session bulk removal of extensive solid debris while preserving vital abdominal vessels through a small incision.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"e83-e85"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure Laparoscopic Living Donor Right Hepatectomy: A Multifactorial Evolutional Learning Curve Analysis From a Single-Surgeon High-Volume Series","authors":"Flavio Milana,&nbsp;Sang Hoon Kim,&nbsp;Alessandro Parente,&nbsp;Ki-Hun Kim","doi":"10.1002/jhbp.70152","DOIUrl":"10.1002/jhbp.70152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pure laparoscopic donor right hepatectomy (PLDRH) is a safe technique, but its learning curve is often oversimplified. This study evaluates variables contributing to evolutional patterns for mastering PLDRH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Consecutive donors undergoing PLDRH at a single center (2014–2021) were collected. A cumulative sum (CUSUM) method assessed a composite score derived from graft weight (GW), bile duct (BD) anatomy, operative time (OT), and warm ischemia time (WIT). Segmented regression identified the statistical breakpoint in the composite learning curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 215 donors, no conversion occurred. Major post-operative complications (Clavien-Dindo ≥ 3) were reported in 2 (0.9%) cases with no mortality. CUSUM analysis identified a significant technical breakpoint at case 180 (<i>p</i> &lt; 0.001). While OT and WIT improved after 60 cases (<i>p</i> &lt; 0.001), surgical complexity, specifically GW and multiple BD, simultaneously increased between 60 and 180 cases. This demonstrates a multiphasic learning process where technical maturity was achieved by case 180, maintaining high safety standards despite progressive inclusion of larger grafts and more complex anatomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The PLDRH learning curve is multifactorial and non-linear. While approximately 60 cases suffice for technical standardization, achieving full mastery over complex donors requires further caution. This multifactorial “evolutional” approach provides a comprehensive understanding for targeted improvement and surgical coaching.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"750-757"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Risk Prediction Model for Prolonged Mechanical Ventilation After Liver Transplantation: A Multicenter Retrospective Study","authors":"Xuejiao Zhou,&nbsp;Jing Hu,&nbsp;Zeliang Xu,&nbsp;Di Jiang,&nbsp;Yao Xie,&nbsp;Xingchao Liu,&nbsp;Guangkai Zhao,&nbsp;Shaohua Song,&nbsp;Xishu Wang,&nbsp;Qingyi Zhang","doi":"10.1002/jhbp.70160","DOIUrl":"10.1002/jhbp.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To identify risk factors for prolonged mechanical ventilation (PMV) after liver transplantation (LT) and to develop and internally validate a predictive nomogram.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multicenter retrospective cohort of 746 LT recipients (January 2015–June 2023) was randomly split 7:3 into training (<i>n</i> = 522) and validation (<i>n</i> = 224) sets. We conducted univariate and multivariate logistic regression to identify factors linked to PMV. A risk nomogram was created based on the multivariate analysis, and its performance was evaluated for calibration, discrimination, and clinical utility, with internal validation using the Validation Set data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence of PMV was 21.6%. Multivariate analysis identified five independent predictors of PMV: ASA scores ≥ 3, mechanical ventilation before LT, MELD score, albumin levels, and anhepatic phase. The nomogram developed from these predictors showed a concordance index (C-index) of 0.780 (95% CI, 0.734–0.827) and demonstrated good calibration. After internal validation, the model maintained a C-index of 0.731 (95% CI, 0.653–0.810). Decision curve analysis and clinical impact curve confirmed the nomogram's effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The nomogram enables individualized PMV risk estimation in LT recipients and may guide early intervention and resource allocation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"736-749"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review","authors":"Takamichi Ishii,&nbsp;Kenta Makino,&nbsp;Etsuro Hatano,&nbsp;Mina Komuta,&nbsp;Jun Akiba,&nbsp;Yoshihiro Sakamoto,&nbsp;Shun-Ichi Ariizumi,&nbsp;Goro Honda,&nbsp;Toru Hisaka,&nbsp;Yutaka Takeda,&nbsp;Akira Shimizu,&nbsp;Kentaro Yasuchika,&nbsp;Takashi Mizuno,&nbsp;Daisuke Asano,&nbsp;Atsushi Fujio,&nbsp;Naoto Gotohda,&nbsp;Chie Kitami,&nbsp;Koji Amaya,&nbsp;Hiroshi Sadamori,&nbsp;Manabu Kawai,&nbsp;Akiyoshi Nakakura,&nbsp;Masafumi Nakamura,&nbsp;Itaru Endo","doi":"10.1002/jhbp.70170","DOIUrl":"10.1002/jhbp.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide multicenter study with centralized pathological review to investigate the features of CLC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included patients with a postoperative diagnosis of CLC at 49 participating institutions (2005–2018). All cases were re-evaluated by centralized pathology according to the WHO classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 196 re-evaluated patients, 56 tumors were classified as CLC, 69 as intrahepatic cholangiocarcinoma (iCCA) with &lt; 80% DC, 53 as small-duct type iCCA with DC, and 16 as mixed small- and large-duct type (SD/LD-iCCA with DC). CLC showed a low prevalence of viral hepatitis (23.2%), frequent arterial enhancement (83.9%), and characteristic apical EMA positivity. The median overall survival (OS) was 10.8 years, with 5- and 10-year OS rates of 85.0% and 73.7%, respectively, which were significantly better than those of SD/LD-iCCA with DC. Recurrence occurred in 38.2% of CLC cases with favorable outcomes following surgical resection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CLC exhibits distinct pathological and prognostic features, including favorable long-term survival, supporting CLC as a distinct clinicopathological entity. Further molecular research is needed to refine the classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study was registered with the UMIN Clinical Trials Registry (UMIN000057919)</p>\u0000 </section>\u0000 </div>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"758-768"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jhbp.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor","authors":"Masafumi Nakamura,&nbsp;the Study Group of Precision Anatomy for Minimally Invasive Hepato-Biliary-Pancreatic Surgery (PAM-HBP Surgery)","doi":"10.1002/jhbp.70140","DOIUrl":"10.1002/jhbp.70140","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time AI-Based Alert System for Head Occlusion: Ensuring Video Quality for Hepato-Biliary-Pancreatic Board Certification","authors":"Shuta Kuchida,&nbsp;Hiroyuki Nitta,&nbsp;Akira Umemura,&nbsp;Daiki Takeda,&nbsp;Taro Ando,&nbsp;Satoshi Amano,&nbsp;Toma Kawashima,&nbsp;Koji Kikuchi,&nbsp;Taku Kimura,&nbsp;Akira Sasaki","doi":"10.1002/jhbp.70157","DOIUrl":"10.1002/jhbp.70157","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"733-735"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of the Effectiveness of Digital Peroral Cholangioscopy-Guided Lithotripsy for Difficult Bile Duct Stones","authors":"Hirohito Minami,&nbsp;Shuntaro Mukai,&nbsp;Takayoshi Tsuchiya,&nbsp;Reina Tanaka,&nbsp;Ryosuke Tonozuka,&nbsp;Kazumasa Nagai,&nbsp;Hiroyuki Kojima,&nbsp;Noriyuki Hirakawa,&nbsp;Kyoko Asano,&nbsp;Takao Itoi","doi":"10.1002/jhbp.70138","DOIUrl":"10.1002/jhbp.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Peroral cholangioscopy-guided lithotripsy (POCS-L) has emerged as a treatment option for difficult bile duct stones (DBDSs), but detailed evidence remains limited. This study evaluated its effectiveness, safety, and risk factors for adverse events (AEs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 132 consecutive patients who underwent POCS-L for DBDSs between December 2014 and July 2023 at Tokyo Medical University Hospital. Electrohydraulic lithotripsy or holmium: yttrium-aluminum-garnet laser lithotripsy was performed under cholangioscopic guidance. The primary outcomes were technical and clinical success, and secondary outcomes included procedure-associated AEs and risk factors for cholangitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The technical and clinical success rates were 98.5% and 94.7%, respectively, with a median procedure time of 56 min. Clinical success was higher for common bile duct stones than intrahepatic bile duct stones (98.0% vs. 83.9%). Procedure-associated AEs occurred in 29.5% of patients, most commonly transient fever (16.7%) and cholangitis (11.4%). Multivariable analysis identified a stone diameter &gt; 20 mm (odds ratio [OR]: 4.79; <i>p</i> = 0.016) and absence of postprocedural biliary drainage (OR: 3.73; <i>p</i> = 0.048) as independent predictors of cholangitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>POCS-L is an effective and safe treatment for DBDSs. Postprocedural biliary drainage may reduce the risk of cholangitis, particularly in patients with large stones.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 10","pages":"789-794"},"PeriodicalIF":2.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jhbp.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}