Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Efficacy and Safety of Surgical Treatment Among Older Adult Patients (80 Years) With Pancreatic Cancer: A Systematic Review and Meta-Analysis. 老年（80岁）胰腺癌手术治疗的有效性和安全性：一项系统综述和荟萃分析。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-14 DOI: 10.1002/jhbp.12151

Naoki Ikenaga, Takao Ohtsuka, Eiji Mitate, Koji Tamura, Masayuki Sho, Masafumi Nakamura

{"title":"Efficacy and Safety of Surgical Treatment Among Older Adult Patients (80 Years) With Pancreatic Cancer: A Systematic Review and Meta-Analysis.","authors":"Naoki Ikenaga, Takao Ohtsuka, Eiji Mitate, Koji Tamura, Masayuki Sho, Masafumi Nakamura","doi":"10.1002/jhbp.12151","DOIUrl":"https://doi.org/10.1002/jhbp.12151","url":null,"abstract":"Background: With rapid population aging, the number of older adult patients presenting with pancreatic cancer is increasing. This meta-analysis aimed to clarify the efficacy and safety of surgical interventions for pancreatic cancer among older adult patients.Methods: Literature published in PubMed, Cochrane Library, and ICHUSHI databases until January 2024 was systematically searched. Comparative studies reporting outcomes of pancreatic cancer resection among patients aged 80 years or older were included in the analysis. Fifteen retrospective studies involving 22 647 patients were included in the meta-analysis: 2930 patients aged 80 years or older who underwent pancreatic resection, 2059 patients aged 80 years or older treated with chemotherapy, and 17 658 patients under 80 years old.Results: Surgical treatment had a higher two-year survival rate than chemotherapy among patients with pancreatic cancer aged 80 years or older. These patients experienced similar morbidity, higher mortality, and lower three-year survival rates than those younger than 80 years.Conclusions: Surgical treatment for pancreatic cancer improves survival rates even among patients aged 80 years or older; however, these patients may have a lower chance of recovering from complications. Patients should be informed of these objective findings to ensure shared decision-making regarding the best treatment strategy.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Particle Beam Therapy for Extrahepatic Biliary Cancer-Updated Systematic Review and Meta-Analysis for Comparison Between Photon and Particle Radiotherapy. 粒子束治疗在肝外胆道癌中的作用光子与粒子放疗比较的最新系统综述和荟萃分析。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-13 DOI: 10.1002/jhbp.12156

Hideya Yamazaki, Takuya Kimoto, Satoshi Teramukai, Mitsuko Nakata, Kei Shibuya, Motohisa Suzuki, Kazuki Terashima, Takashi Iizumi, Masaru Wakatsuki, Takayuki Hashimoto, Takumi Fukumoto, Masayuki Ohtsuka

{"title":"Role of Particle Beam Therapy for Extrahepatic Biliary Cancer-Updated Systematic Review and Meta-Analysis for Comparison Between Photon and Particle Radiotherapy.","authors":"Hideya Yamazaki, Takuya Kimoto, Satoshi Teramukai, Mitsuko Nakata, Kei Shibuya, Motohisa Suzuki, Kazuki Terashima, Takashi Iizumi, Masaru Wakatsuki, Takayuki Hashimoto, Takumi Fukumoto, Masayuki Ohtsuka","doi":"10.1002/jhbp.12156","DOIUrl":"https://doi.org/10.1002/jhbp.12156","url":null,"abstract":"Background/purpose: The study was designed to examine the role of particle beam therapy (PT) in the treatment of extrahepatic biliary cancer (EHC).Methods: We conducted a systematic review and meta-analysis to compare the outcomes of PT and photon radiotherapy in treating EHC. Medline/PubMed and Japan Medical Abstracts databases were screened using a systematic search strategy. The primary endpoint was overall survival (OS), pooled using a random effects model.Results: In total, 236 articles were retrieved. After screening, 11 articles were retained, comprising 2108 patients (nine photon articles, n = 2038 patients; two PT articles, n = 70 patients). We have updated and incorporated the outcomes of the prospective data registry (Proton-net, n = 137 patients) for PT. The 1-year OS probability rates were 56% (95% confidence interval = 49%-62%) for the photon and 72% (65%-78%) for the PT groups (p < 0.001). The median survival time was 13.1 months (11.0-15.1 months) for the photon group and 18.8 months (14.1-23.4 months) for the PT group (p = 0.03). The PT group demonstrated a superior OS rate compared to that observed in the photon group. The incidence rates of grade 3 ≤ toxicity was 18.5%-33% in the photon radiotherapy group and 2.9%-15% in the PT group.Conclusion: PT demonstrated superior outcomes with acceptable toxicity compared to those noted with photon radiotherapy for EHC in this meta-analysis. In the absence of randomized trials, this meta-analysis provides useful evidence that PT can be considered an effective therapeutic modality for EHC.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the Outcomes of Advanced Hepatobiliary-Pancreatic Surgery: The Impact of a Nationwide Clinical Database and Surgeon Certification System. 晚期肝胆胰手术预后的趋势：全国临床数据库和外科医生认证系统的影响。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-13 DOI: 10.1002/jhbp.12158

Takayuki Anazawa, Hiroyuki Yamamoto, Etsuro Hatano, Mitsukazu Gotoh, Masafumi Nakamura, Masayuki Ohtsuka, Itaru Endo

{"title":"Trends in the Outcomes of Advanced Hepatobiliary-Pancreatic Surgery: The Impact of a Nationwide Clinical Database and Surgeon Certification System.","authors":"Takayuki Anazawa, Hiroyuki Yamamoto, Etsuro Hatano, Mitsukazu Gotoh, Masafumi Nakamura, Masayuki Ohtsuka, Itaru Endo","doi":"10.1002/jhbp.12158","DOIUrl":"https://doi.org/10.1002/jhbp.12158","url":null,"abstract":"Background: The Japanese Society of Hepatobiliary and Pancreatic Surgery has established a certification system for experienced surgeons. Evaluating its efficacy requires accounting for patient risk variations. The National Clinical Database (NCD) facilitates this using risk-adjusted outcome measures to validate and compare surgical performance.Methods: We analyzed the NCD from 2014 to 2020 to examine trends in adjusted odds ratios (AORs) for mortality and morbidity following pancreaticoduodenectomy using 2014 as the reference. Primary outcomes were surgical and 30-day postoperative mortality. Secondary outcomes included severe complications and grade C pancreatic fistula. Subgroup analyses considered surgeon and institutional certification.Results: Analysis of 78 972 pancreaticoduodenectomy reports revealed a decrease in the AOR for surgical mortality from 0.906 (95% Confidence Interval [CI]: 0.759-1.082, p = 0.276) in 2015 to 0.647 (95% CI: 0.539-0.777, p < 0.001) in 2020. A significant downward trend in the incidence of Grade C pancreatic fistula was observed. Board-certified surgeons have demonstrated superior performance compared to nonboard-certified surgeons since 2014, with board-certified training institutions having significantly lower AORs than those without certification. The AOR for surgical mortality showed an annual decrease across institutions.Conclusions: The certification system for hepatobiliary-pancreatic surgery and participation in the NCD significantly decreased surgical mortality after pancreaticoduodenectomy.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicenter Comparative Study of 6- and 10-mm Fully Covered Self-Expandable Metal Stents for Malignant Distal Biliary Obstruction During Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Cancer. 可切除和交界性可切除胰腺癌新辅助化疗期间，6毫米和10毫米全覆盖自扩张金属支架治疗恶性胆道远端梗阻的多中心比较研究。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-12 DOI: 10.1002/jhbp.12157

Arata Sakai, Atsuhiro Masuda, Mamoru Takenaka, Hideyuki Shiomi, Shunsuke Omoto, Akihiro Yoshida, Ryota Nakano, Yuta Kawase, Shinya Kohashi, Yuzo Kodama

{"title":"Multicenter Comparative Study of 6- and 10-mm Fully Covered Self-Expandable Metal Stents for Malignant Distal Biliary Obstruction During Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Cancer.","authors":"Arata Sakai, Atsuhiro Masuda, Mamoru Takenaka, Hideyuki Shiomi, Shunsuke Omoto, Akihiro Yoshida, Ryota Nakano, Yuta Kawase, Shinya Kohashi, Yuzo Kodama","doi":"10.1002/jhbp.12157","DOIUrl":"https://doi.org/10.1002/jhbp.12157","url":null,"abstract":"Background: The use of 10-mm fully covered self-expandable metal stents for preoperative bile duct drainage in patients with pancreatic cancer is increasing. However, these can cause complications (cholecystitis and pancreatitis) that may affect surgical outcomes. Smaller-diameter self-expandable metal stents may reduce these risks; however, the optimal stent size is unclear.Methods: Patients with pancreatic cancer who underwent neoadjuvant chemotherapy and placement of either 6 or 10-mm fully covered self-expandable metal stents for malignant distal biliary obstruction were included. The primary outcome was the 90-day incidence of recurrent biliary obstruction. Secondary outcomes were non-recurrent biliary obstruction and adverse events.Results: Fifty-three patients were enrolled (27 and 26 patients received 6-mm and 10-mm self-expandable metal stents, respectively). The 90-day incidence of recurrent biliary obstruction of the 6-mm group was significantly higher than that of the 10-mm group (30.8% vs. 3.8%; p = 0.02). Stent migration occurred more frequently in the 6-mm group (26.9% vs. 0%; p = 0.01). Although non-recurrent biliary obstruction adverse events were less common in the 6-mm group, the difference was not statistically significant (11.1% vs. 23.0%; p = 0.29).Conclusions: The 10-mm self-expandable metal stents were more suitable for the preoperative management of pancreatic cancer.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Cholangitis Caused by Migration of a Pancreatic Stent Into a Biliary Stent. 胰腺支架向胆道支架迁移引起的急性胆管炎。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-09 DOI: 10.1002/jhbp.12155

Ryo Jimbo, Toshifumi Sato, Shuji Terai

引用次数: 0

Correction to "Usefulness of simplified comprehensive geriatric assessment as a pre-ERCP screening for the elderly". 更正“简化综合老年病评估作为ercp前老年人筛查的有用性”。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-05 DOI: 10.1002/jhbp.12125

引用次数: 0

Clinical and radiological predictive features for high-grade and invasive carcinoma in intraductal papillary mucinous neoplasms: A systematic review. 导管内乳头状黏液性肿瘤中高级别癌和浸润性癌的临床和放射学预测特征：一项系统综述。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-05-04 DOI: 10.1002/jhbp.12150

Camila Hidalgo Salinas, Christopher L Wolfgang, Joseph R Habib

{"title":"Clinical and radiological predictive features for high-grade and invasive carcinoma in intraductal papillary mucinous neoplasms: A systematic review.","authors":"Camila Hidalgo Salinas, Christopher L Wolfgang, Joseph R Habib","doi":"10.1002/jhbp.12150","DOIUrl":"https://doi.org/10.1002/jhbp.12150","url":null,"abstract":"Background/purpose: Intraductal papillary mucinous neoplasms (IPMNs) progress from low-grade dysplasia to high-grade dysplasia (HGD) or invasive carcinoma (IC). High diagnostic accuracy is critical for surgical decision-making.Methods: We searched Medline, Embase, and Cochrane Library from January 1, 2015, to January 27, 2025. Eligible studies reported on resected IPMNs, assessing diagnostic features for HGD/IC. Two reviewers screened articles, extracted data, and assessed bias using the Newcastle-Ottawa scale. Descriptive statistics summarized outcomes. The performance of worrisome features (WFs) and high-risk stigmata (HRS) based on International Association of Pancreatology guidelines were evaluated.Results: In the 53 studies, 12 953 patients were included. HRS including obstructive jaundice and enhancing mural nodules ≥5mm showed robust specificity for HGD/IC, while main pancreatic duct size ≥10mm showed variable diagnostic accuracy. WFs such as cyst size ≥3 cm performed poorly, while cyst growth rate >3.5 mm/year demonstrated higher sensitivity (88%) and specificity (91%). Although rare, abrupt caliber change with distal atrophy was a robust predictor of malignancy (median odds ratio: 3.01). Acute pancreatitis and lymphadenopathy displayed variable value. Incremental improvement in diagnostic accuracy was observed with additional HRS or WFs.Conclusions: Current diagnostic markers are valuable but provide limited guidance for surgical decision-making in IPMNs, highlighting the need for further refinement of diagnostic tools.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to the Letter by Dr. Ranjana Sah Et al. 答复Ranjana Sah博士等人的来信。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-04-29 DOI: 10.1002/jhbp.12153

Yoji Kishi, Teiichi Sugiura, Takashi Mizuno

引用次数: 0

Letter to the Editor for "Comparable Impact of Lymph Node Metastases in T2 Gallbladder Cancer on Postoperative Prognosis Irrespective of the Extent of the Metastases: A Retrospective Analysis". 致编辑的信，题目是“无论转移程度如何，T2胆囊癌淋巴结转移对术后预后的影响：回顾性分析”。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-04-25 DOI: 10.1002/jhbp.12154

Ranjana Sah, Rachana Mehta, Amogh Verma

引用次数: 0

Pigtail Stent-Stone Complex in the Gallbladder: A Rare Adverse Event Following Long-Term Placement of an Endoscopic Gallbladder Stent. 长时间放置内窥镜胆囊支架后的罕见不良事件：胆囊内的辫状支架-结石复合物。