Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Prognostic Impact of Unplanned Total Pancreatectomy in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis. 非计划全胰切除术对胰管腺癌预后的影响：回顾性分析。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-07-02 DOI: 10.1002/jhbp.12176

Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Takuya Nakai, Mamoru Takenaka, Takaaki Chikugo, Ippei Matsumoto

{"title":"Prognostic Impact of Unplanned Total Pancreatectomy in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis.","authors":"Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Takuya Nakai, Mamoru Takenaka, Takaaki Chikugo, Ippei Matsumoto","doi":"10.1002/jhbp.12176","DOIUrl":"https://doi.org/10.1002/jhbp.12176","url":null,"abstract":"Background: This study evaluated the clinical significance of an unplanned total pancreatectomy (TP) by comparing surgical outcomes of planned and unplanned TP for pancreatic ductal adenocarcinoma (PDAC).Methods: Forty-two patients who underwent TP for PDAC between 2009 and 2020 at the Kindai University Hospital were retrospectively analyzed. We evaluated the differences in the prognosis and related factors between planned and unplanned TP, and independent prognostic factors of TP for PDAC.Results: Twenty-three patients underwent planned TP, and 19 underwent unplanned TP. There were no significant differences in clinicopathological data between the two groups, except for microscopic vascular invasion. However, the unplanned TP group had significantly better overall survival (OS) and recurrence-free survival (RFS) times than the planned TP group. In the multivariate analysis of the prognostic factors of TP for PDAC, a planned TP and not receiving or completing postoperative adjuvant chemotherapy (AC) were independent poor prognostic factors.Conclusion: This study supports a rigorous approach to margin clearance in TP for PDAC to achieve curative negative margins in cancer-positive pancreatic resection stumps. However, the prognosis of a planned TP for PDAC is extremely poor, and adequate preoperative and multidisciplinary treatment may be necessary to prolong the prognosis.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Metabolic Response During Preoperative Chemotherapy Can Predict Prognosis in Pancreatic Cancer". 修正“术前化疗期间的代谢反应可以预测胰腺癌预后”。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-07-01 DOI: 10.1002/jhbp.12170

引用次数: 0

Correction to "Short- and Long-Term Outcomes of Liver Resection With Hepatic Vein Reconstruction for Liver Tumors: A Nationwide Multicenter Survey". 更正“肝肿瘤肝切除肝静脉重建的短期和长期疗效：一项全国多中心调查”。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-27 DOI: 10.1002/jhbp.12180

引用次数: 0

Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer. 胰腺癌淋巴结位置指标对预后的影响及对最佳区域淋巴结位置的重新考虑。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-25 DOI: 10.1002/jhbp.12179

Suguru Yamada, Tsutomu Fujii, Kenji Oshima, Kosuke Nomoto, Yukiko Oshima, Masamichi Hayashi, Akimasa Nakao

{"title":"Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer.","authors":"Suguru Yamada, Tsutomu Fujii, Kenji Oshima, Kosuke Nomoto, Yukiko Oshima, Masamichi Hayashi, Akimasa Nakao","doi":"10.1002/jhbp.12179","DOIUrl":"https://doi.org/10.1002/jhbp.12179","url":null,"abstract":"Purposes: Regional lymphadenectomy is standard in pancreatic cancer. The aim was to explore clinical impact for the prognostic index of nodal stations and optimal extent of lymphadenectomy in pancreatic cancer.Methods: A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.Results: In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.Conclusion: Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Patients With Asymptomatic Common Bile Duct Stones Compared to Symptomatic Cases: A Propensity Score-Matched Cohort Analysis. 无症状胆总管结石患者与有症状患者相比，内镜后逆行胆管造影胰腺炎的风险更高：倾向评分匹配队列分析

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-24 DOI: 10.1002/jhbp.12178

Fumiya Kataoka, Mitsuru Okuno, Tsuyoshi Mukai, Atsushi Tagami, Hiroshi Araki, Junichi Sugihara, Eiichi Tomita, Hisataka Moriwaki, Atsushi Masamune, Masahito Shimizu

{"title":"Higher Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Patients With Asymptomatic Common Bile Duct Stones Compared to Symptomatic Cases: A Propensity Score-Matched Cohort Analysis.","authors":"Fumiya Kataoka, Mitsuru Okuno, Tsuyoshi Mukai, Atsushi Tagami, Hiroshi Araki, Junichi Sugihara, Eiichi Tomita, Hisataka Moriwaki, Atsushi Masamune, Masahito Shimizu","doi":"10.1002/jhbp.12178","DOIUrl":"https://doi.org/10.1002/jhbp.12178","url":null,"abstract":"Background and aims: Endoscopic retrograde cholangiopancreatography (ERCP), the standard procedure for common bile duct (CBD) stones (CBDS) removal, carries a risk of post-ERCP pancreatitis (PEP). We compared PEP-related factors between asymptomatic and symptomatic CBDS cases.Methods: A retrospective cohort study was conducted on 367 patients who underwent ERCP for CBDS. To adjust for baseline differences, propensity score matching (PSM) was performed, yielding 170 matched patients (85 asymptomatic and 85 symptomatic groups) for comparative analysis of PEP-related factors.Results: Baseline differences in the proportion of patients with American Society of Anesthesiologists-Physical Status (≥ 3) cases, CBD diameter, and CBDS size were eliminated after PSM. The asymptomatic group had a significantly longer ERCP procedure time (20 vs. 18-min, p = 0.02) and a higher incidence of PEP compared to the symptomatic group (11.8% vs. 1.2%, p = 0.01). Multivariate analysis confirmed that asymptomatic CBDS cases (odds ratio [OR]: 9.37, 95% confidence interval [CI]: 1.13-77.6, p = 0.0381) and prolonged procedure time (> 26 min, OR: 5.29, 95% CI: 1.26-22.3, p = 0.0231) were independent risk factors for PEP.Conclusions: ERCP procedures performed for asymptomatic CBDS cases are associated with a higher risk of PEP. The decision to perform ERCP in asymptomatic CBDS cases should carefully consider the PEP risk factors of the patient.Trial registration: UMIN000055951.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Pancreatic Fistula Between Robotic-Assisted and Open Pancreatoduodenectomy: A Comprehensive Evaluation Using an Alternative Fistula Risk Score. 机器人辅助胰十二指肠切除术与开放式胰十二指肠切除术胰瘘的比较：使用替代瘘风险评分的综合评估。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-21 DOI: 10.1002/jhbp.12167

Charnwit Assawasirisin, Youngmin Han, Hye-Sol Jung, Won-Gun Yun, Yoon Soo Chae, Wooil Kwon, Joon Seong Park, Jin-Young Jang

{"title":"Comparison of Pancreatic Fistula Between Robotic-Assisted and Open Pancreatoduodenectomy: A Comprehensive Evaluation Using an Alternative Fistula Risk Score.","authors":"Charnwit Assawasirisin, Youngmin Han, Hye-Sol Jung, Won-Gun Yun, Yoon Soo Chae, Wooil Kwon, Joon Seong Park, Jin-Young Jang","doi":"10.1002/jhbp.12167","DOIUrl":"10.1002/jhbp.12167","url":null,"abstract":"Background: Robotic-assisted pancreatoduodenectomy (RPD) offers ergonomic advantages, yet its effect on pancreatic fistula risk remains unclear. This study evaluated RPD safety using the alternative fistula risk score (aFRS).Methods: We retrospectively reviewed the pancreatoduodenectomy database at Seoul National University Hospital (2014-2023), comparing RPD with open pancreatoduodenectomy (OPD) in a 1:1 aFRS probability-matched analysis. Baseline characteristics and outcomes were compared overall and by aFRS risk groups.Results: In the matched cohort, RPD patients had a similar BMI but a higher incidence of soft pancreatic texture, smaller ducts, and increased aFRS probability compared to OPD. Overall, clinically relevant postoperative pancreatic fistula (CR-POPF) rates were similar (11% vs. 10%, p = 0.84). However, RPD had lower rates of delayed gastric emptying (3.1% vs. 5.4%, p = 0.024) and wound complications (1.9% vs. 5.5%, p < 0.001). Notably, in the high-risk aFRS group, RPD demonstrated significantly lower CR-POPF rates both before (12% vs. 18%, p = 0.049) and after matching (11% vs. 17%, p = 0.042).Conclusion: RPD is a safe and feasible approach, offering particular benefits in reducing CR-POPF among high-risk patients.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor. 给编辑的信。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-19 DOI: 10.1002/jhbp.12173

Kazumasa Nagai, Takao Itoi

引用次数: 0

Bone Mineral Density Decline in Long-Term Pancreaticoduodenectomy Survivors: Dynamics and Risk Factors. 长期胰十二指肠切除术幸存者骨矿物质密度下降：动态和危险因素。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-16 DOI: 10.1002/jhbp.12175

Yuhei Endo, Hiroshi Noda, Hidetoshi Aizawa, Koetsu Inoue, Fumiaki Watanabe, Takaharu Kato, Yuki Mizusawa, Natsumi Matsuzawa, Toshiki Rikiyama

{"title":"Bone Mineral Density Decline in Long-Term Pancreaticoduodenectomy Survivors: Dynamics and Risk Factors.","authors":"Yuhei Endo, Hiroshi Noda, Hidetoshi Aizawa, Koetsu Inoue, Fumiaki Watanabe, Takaharu Kato, Yuki Mizusawa, Natsumi Matsuzawa, Toshiki Rikiyama","doi":"10.1002/jhbp.12175","DOIUrl":"https://doi.org/10.1002/jhbp.12175","url":null,"abstract":"Background/purpose: The dynamics of bone mineral density (BMD) decrease after pancreaticoduodenectomy in long-term survivors and its risk factors have scarcely been studied.Methods: Seventy-nine patients who underwent pancreaticoduodenectomy and survived for > 5 years were included in this study. We measured the mean CT Hounsfield Unit [HU] values of the anterior trabecular portion of the 1st through 4th lumbar vertebral bodies on a single axial CT scan before pancreaticoduodenectomy and at 1, 2, 3, 4, and 5 years postoperatively. The mean HU values for the 1st to 4th lumbar vertebrae were used as the BMD index.Results: The percentage annual BMD index decrease after pancreaticoduodenectomy was as follows: before pancreaticoduodenectomy and 1st year postoperatively, 18.9% (p < 0.001); 1-2 years postoperatively, 3.9% (p = 0.014); and 4-5 years postoperatively, 3.9% (p = 0.030). A multivariate analysis revealed that the presence of preoperative obstructive jaundice (β = -5.2; 95% confidence interval -9.6 to -0.7, p = 0.023) and long postoperative hospital stay (β = -7.0; 95% confidence interval - 13.4 to -0.7, p = 0.031) were significantly associated with BMD index decrease until the 1st year after pancreaticoduodenectomy.Conclusions: This study identified a rapid decrease of BMD after pancreaticoduodenectomy. Preoperative obstructive jaundice and long postoperative hospital stay are significant risk factors for decreased BMD after pancreaticoduodenectomy.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma. 辅助化疗在远端胆管癌中的作用。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-12 DOI: 10.1002/jhbp.12163

Yoon Soo Chae, Youngmin Han, Go-Won Choi, Younsoo Seo, Inhyuck Lee, Won-Gun Yun, Hye-Sol Jung, Wooil Kwon, Joon Seong Park, Jin-Young Jang

{"title":"Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma.","authors":"Yoon Soo Chae, Youngmin Han, Go-Won Choi, Younsoo Seo, Inhyuck Lee, Won-Gun Yun, Hye-Sol Jung, Wooil Kwon, Joon Seong Park, Jin-Young Jang","doi":"10.1002/jhbp.12163","DOIUrl":"https://doi.org/10.1002/jhbp.12163","url":null,"abstract":"Background: Recent studies addressing the role of adjuvant chemotherapy (AC) in cholangiocarcinoma (CCA) have been published; however, there are challenges in generalizing the findings due to different prognostic characteristics depending on tumor location and resectability. Therefore, this study aimed to investigate the role of AC in distal cholangiocarcinoma (dCCA), a common tumor subtype of CCA.Method: Data from 497 patients with dCCA who underwent curative surgery at Seoul National University Hospital between 2000 and 2019 were reviewed using prospectively collected clinicopathologic information.Results: The median overall survival (OS) and recurrence-free survival (RFS) in the entire cohort were 62.9 and 44.0 months, respectively. AC was associated with improved five-year OS (58.5% vs. 46.4%; p < 0.001) and RFS (49.9% vs. 40.7%; p = 0.005), particularly in patients with advanced T stages (≥ T3). Multivariate analysis revealed that AC was an independent positive prognostic factor for survival. Furthermore, adjuvant radiotherapy (RT) alone provides no survival benefit, whereas AC combined with RT (AC + RT) offers greater benefits, particularly for patients with positive resection margins.Conclusion: AC improved the postoperative survival outcomes of patients with dCCA who underwent curative surgery. Furthermore, AC + RT appears to provide greater benefits, especially for patients with positive resection margins.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply to the Letter to the Editor. 作者给编辑的回信。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-06-10 DOI: 10.1002/jhbp.12168

Dharmenaan Palamuthusingam, Camel M Hawley, Magid Fahim

引用次数: 0