Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Current trends in types of pancreatoduodenectomy: Focus on the advancement of robot-assisted pancreatoduodenectomy with 630 consecutive cases. 胰十二指肠切除术类型的当前趋势：重点介绍机器人辅助胰十二指肠切除术的进展，连续病例数达 630 例。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-18 DOI: 10.1002/jhbp.12086

Mirang Lee, Yoon Soo Chae, Seulah Park, Won-Gun Yun, Hye-Sol Jung, Youngmin Han, Wooil Kwon, Joon Seong Park, Jin-Young Jang

{"title":"Current trends in types of pancreatoduodenectomy: Focus on the advancement of robot-assisted pancreatoduodenectomy with 630 consecutive cases.","authors":"Mirang Lee, Yoon Soo Chae, Seulah Park, Won-Gun Yun, Hye-Sol Jung, Youngmin Han, Wooil Kwon, Joon Seong Park, Jin-Young Jang","doi":"10.1002/jhbp.12086","DOIUrl":"10.1002/jhbp.12086","url":null,"abstract":"Background: Pancreatoduodenectomy (PD) is a complex abdominal surgery, and the adoption of robotic PD has been on the rise because of its numerous benefits. This study aimed to investigate the current PD trends, focusing on advancements in robotic surgery.Methods: Between 2015 and 2023, 1231 patients underwent open PD, whereas 630 underwent robot-assisted PD (RAPD). Demographics and surgical outcomes were analyzed according to the time period. Moreover, a propensity score-matched (PSM) analysis was performed to evaluate the clinical outcomes.Results: The proportion of RAPD cases gradually increased from 6.3% in 2015 to 50.9% in 2020, reaching a plateau of >50% thereafter. The proportion of patients receiving neoadjuvant chemotherapy increased during the late period (11.4% vs. 17.6%), with many of these patients undergoing open PD. Additionally, RAPD was performed in patients with a high probability of postoperative pancreatic fistula. However, the two groups demonstrated no significant difference in the occurrence of clinically relevant postoperative pancreatic fistula (10.6% vs. 9.5%, p = .532). Among periampullary cancer cases, RAPD demonstrated comparable survival outcomes to open PD after PSM (5-year survival rate: 61.8% vs. 49.8%, p = .189).Conclusions: RAPD has become a stable approach, accounting for over 50% of all PD cases in high-volume centers, and it can be safely performed. However, open PD remains important owing to the development of neoadjuvant therapy and the aging population. Therefore, establishing appropriate indications to maximize the benefits of both RAPD and open PD is necessary.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An artificial intelligence-based recognition model of colorectal liver metastases in intraoperative ultrasonography with improved accuracy through algorithm integration. 基于人工智能的术中超声成像结直肠肝转移识别模型，通过算法集成提高了准确性。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-15 DOI: 10.1002/jhbp.12089

Maho Takayama, Kyoji Ito, Kenji Karako, Yuichiro Mihara, Shu Sasaki, Akihiko Ichida, Takeshi Takamoto, Nobuhisa Akamatsu, Yoshikuni Kawaguchi, Kiyoshi Hasegawa

{"title":"An artificial intelligence-based recognition model of colorectal liver metastases in intraoperative ultrasonography with improved accuracy through algorithm integration.","authors":"Maho Takayama, Kyoji Ito, Kenji Karako, Yuichiro Mihara, Shu Sasaki, Akihiko Ichida, Takeshi Takamoto, Nobuhisa Akamatsu, Yoshikuni Kawaguchi, Kiyoshi Hasegawa","doi":"10.1002/jhbp.12089","DOIUrl":"https://doi.org/10.1002/jhbp.12089","url":null,"abstract":"Background/purpose: Contrast-enhanced intraoperative ultrasonography (CE-IOUS) is crucial for detecting colorectal liver metastases (CLM) during surgery. Although artificial intelligence shows potential in diagnostic systems, its application in CE-IOUS is limited.Methods: This study aimed to develop an automatic tumor detection model using Mask region-based convolutional neural network (Mask R-CNN) for CE-IOUS images. CE-IOUS videos of the CLM from 121 patients were collected, generating ground truth data. A total of 2659 images were obtained. Two models were developed: the basic recognition model (BRM), which was trained on CE-mode images, and the subtraction model (SM), which used images created by a subtraction algorithm that highlighted the differences in pixel values between the basic-mode and CE-mode images. The subtraction algorithm focuses on echogenicity differences. These two models were combined into a combination model (CM), which assessed outcomes using the prediction probabilities from both models.Results: The optimal epochs were determined by the maximum area under the curve (AUC), and the thresholds were calculated accordingly. BRM, SM, and CM achieved 89.4%, 86.6%, and 96.5% accuracy, respectively. CM outperformed the individual models, achieving an AUC of 0.99.Conclusions: A novel automated recognition model was developed for accurate CLM detection in CE-IOUS by integrating image- and algorithm-based models.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating antibiotic therapy in acute cholangitis: Best practices and new insights. 指导急性胆管炎的抗生素治疗：最佳实践与新见解。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-13 DOI: 10.1002/jhbp.12087

Sakue Masuda, Yoshinori Imamura, Ryuhei Jinushi, Karen Kimura, Shomei Ryozawa, Kazuya Koizumi

{"title":"Navigating antibiotic therapy in acute cholangitis: Best practices and new insights.","authors":"Sakue Masuda, Yoshinori Imamura, Ryuhei Jinushi, Karen Kimura, Shomei Ryozawa, Kazuya Koizumi","doi":"10.1002/jhbp.12087","DOIUrl":"https://doi.org/10.1002/jhbp.12087","url":null,"abstract":"Globally, antibiotic resistance is linked to increased morbidity, mortality, and healthcare costs, which necessitates further research on optimal antibiotic usage. Acute cholangitis (AC), a common cause of community-acquired bacteremia, often requires antimicrobial therapy. Therefore, studying the appropriate use of antibiotics for AC is considered crucial for suppressing the emergence of resistant bacteria and reducing adverse antibiotic-associated events. The Tokyo Guidelines 2018 (TG18) recommend 4-7 days of antibiotics post-biliary drainage. However, this lacks strong evidence and is based primarily on various evidence and expert opinions. Recent retrospective studies advocate for a shorter 1-3-day antibiotic course for AC, thereby prompting a need to reassess the treatment duration to balance therapeutic efficacy and minimize resistance and adverse effects. Choosing the appropriate duration and antibiotics based on susceptibility to pathogens causing cholangitis is important. Awareness of local resistance patterns and understanding patients' risks of resistant pathogens are prerequisite for effective treatment. We must explore the applicability of these guidelines in specific scenarios such as severe AC, positive blood cultures, fever, or hilar biliary obstructions due to malignancy. This comprehensive review considers both the duration and type of antibiotics and aims to enhance treatment outcomes while reducing the risk of resistant bacterial infections.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral administration of poly-ICLC enhances the antitumor effects of anti-PD-1. 瘤内给药聚-ICLC可增强抗-PD-1的抗肿瘤作用。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-13 DOI: 10.1002/jhbp.12088

Shin-Yun Liu, Chia-Lang Hsu, Shih-Feng Yang, Hsuan-Shu Lee, Jin-Chuan Sheu, Meng-Tzu Weng

{"title":"Intratumoral administration of poly-ICLC enhances the antitumor effects of anti-PD-1.","authors":"Shin-Yun Liu, Chia-Lang Hsu, Shih-Feng Yang, Hsuan-Shu Lee, Jin-Chuan Sheu, Meng-Tzu Weng","doi":"10.1002/jhbp.12088","DOIUrl":"https://doi.org/10.1002/jhbp.12088","url":null,"abstract":"Background: Immune checkpoint inhibitors are effective to treat hepatocellular carcinoma (HCC) yet only successful in a small part of patients. This study aimed to investigate whether poly-ICLC, an immune stimulant, can enhance the antitumor effects of anti-PD-1 on mouse HCC.Methods: We established two syngeneic HCC mouse models with BNL cells in BALB/c mice and Hep-55.1 C cells in C57BL/6 J mice. Mice with subcutaneous HCC tumors received one of five treatments: control, anti-PD-1, intratumoral (IT) poly-ICLC, anti-PD-1 plus intramuscular (IM) poly-ICLC, or anti-PD-1 plus IT poly-ICLC. Tumor volumes were measured, CD8+ T lymphocytes in tumors and spleen were analyzed, and interferon-γ activity was assessed by ELISpot. Immune cell types and abundance were evaluated with NanoString nCounter IO360 panels.Results: Cotreatment with poly-ICLC significantly enhanced the antitumor effects of anti-PD-1, with IT administration being more effective than IM. IT poly-ICLC also induced more significant CD8+ T cell infiltration and interferon-γ activity in the tumor and spleen, and more upregulation of both interferon-γ and M1 macrophage signals in the tumor microenvironment while downregulating several cancer-promoting pathways.Conclusions: Combination therapy with poly-ICLC, especially through IT route, and anti-PD-1 provides significantly greater antitumor effects than anti-PD-1 monotherapy in syngeneic mouse models of HCC.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan. 2013年至2017年间5085例新确诊结直肠肝转移患者的综合数据：日本全国调查第四次报告。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-12 DOI: 10.1002/jhbp.12078

Katsunori Sakamoto, Toru Beppu, Goro Honda, Kenjiro Kotake, Masakazu Yamamoto, Keiichi Takahashi, Itaru Endo, Kiyoshi Hasegawa, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Shin Kobayashi, Tatsuro Yamaguchi, Kazushige Kawai, Soichiro Natsume, Ken Tabuchi, Hirotoshi Kobayashi, Kensei Yamaguchi, Kimitaka Tani, Satoshi Morita, Yoichi Ajioka, Masaru Miyazaki, Kenichi Sugihara

{"title":"Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan.","authors":"Katsunori Sakamoto, Toru Beppu, Goro Honda, Kenjiro Kotake, Masakazu Yamamoto, Keiichi Takahashi, Itaru Endo, Kiyoshi Hasegawa, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Shin Kobayashi, Tatsuro Yamaguchi, Kazushige Kawai, Soichiro Natsume, Ken Tabuchi, Hirotoshi Kobayashi, Kensei Yamaguchi, Kimitaka Tani, Satoshi Morita, Yoichi Ajioka, Masaru Miyazaki, Kenichi Sugihara","doi":"10.1002/jhbp.12078","DOIUrl":"https://doi.org/10.1002/jhbp.12078","url":null,"abstract":"The Joint Committee for Nationwide Survey on colorectal liver metastasis (CRLM) was established to improve treatment outcomes in patients with CRLM. The aim of this study was to evaluate the transition in the characteristics and treatment strategies of patients with CRLM and to analyze the prognostic factors. The data of 5085 patients newly diagnosed between 2013 and 2017 were compared with those of 3820 patients from 2005 and 2007. In patients who underwent hepatectomy (n = 2759 and 2163), the number of CRLMs was significantly higher and in the 2013-2017 data than in the 2005-2007 data (median 2 vs. 1; p = .005). Overall survival (OS) rates after diagnosis of CRLM after hepatectomy were better in the 2013-2017 data than that in the 2005-2007 data (5-year OS, 62.4% vs. 56.7%, p < .001). Recurrence-free survival (RFS) after hepatectomy was comparable between the groups (5-year RFS, 30.5% vs. 30.7%; p = .068). Multivariate analyses identified age at diagnosis of CRLM ≥70 years, lymph node metastasis of primary lesion, preoperative carbohydrate antigen (CA) 19-9 value >100 U/mL, number of CRLM 2-4, and R2 resection as independent predictors of OS. Synchronous CRLM, concomitant extrahepatic metastasis, lymphatic invasion, lymph node metastasis of primary lesion, preoperative CA19-9 value >100 U/mL, number of CRLM 5-, and nonlaparoscopic approach were selected as that of RFS. Despite having a higher prevalence of advanced stage CRLM in the 2013-2017 patient population compared to the 2005-2007 cohort, prognostic outcomes demonstrably improved in the later period.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Same day discharge after hepatectomy: Can it be done safely? 肝切除术后当天出院：可以安全地做到吗？

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-07 DOI: 10.1002/jhbp.12076

Zain Kashif, Sayed Imtiaz, Saif Ahmed, Juliet Emamaullee, Mohd Raashid Sheikh

{"title":"Same day discharge after hepatectomy: Can it be done safely?","authors":"Zain Kashif, Sayed Imtiaz, Saif Ahmed, Juliet Emamaullee, Mohd Raashid Sheikh","doi":"10.1002/jhbp.12076","DOIUrl":"10.1002/jhbp.12076","url":null,"abstract":"Background: With the advent of minimally invasive techniques and enhanced recovery pathways, outpatient surgery is becoming increasingly common, but has not yet been extensively described in liver surgery. The aim of the present study was to analyze the incidence, characteristics, and outcomes of patients undergoing outpatient hepatectomy in the US.Methods: We utilized the National Surgical Quality Improvement Program (NSQIP) database for patients who underwent laparoscopic or robotic, elective hepatectomy from 2014 to 2021. Patients discharged on postoperative day 0 were assigned to the \"same-day discharge\" group, otherwise the patient was considered \"admitted.\" Postoperative outcomes were compared with propensity-matched analysis. Multivariate analysis was performed to identify predictors of postoperative LOS (length of stay).Results: We identified 7279 patients, of which 361 were in the same-day discharge cohort and 6918 were in the admitted cohort. For admitted patients, median postoperative length of stay was three days (SD = 6). Same-day discharge patients tended to be younger (age 59 vs. 62, p = .034) and more often ASA class ≤2 (49% vs. 29%, p < .001). Comorbidities such as hypertension (40% vs. 45%, p = .048) and diabetes (12% vs. 19%, p = .002) were less common in the same-day discharge cohort. On propensity-matched comparison, there was no significant difference in 30-day mortality (p > .9), 30-day readmission (p = .2), and overall postoperative complication rate (p = .2). Predictors of longer postoperative LOS included longer operative time, inpatient hospital status, preoperative transfusion, dependent functional status, and use of neoadjuvant chemotherapy.Conclusion: Our results indicate that for low-risk patients and uncomplicated cases, same-day discharge after minimally invasive, elective hepatectomy is feasible without compromising patient safety and outcomes.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor for "Evaluation of prognostic efficacy of liver immune status index in predicting postoperative outcomes in hepatocellular carcinoma patients: A multi-institutional retrospective study". 致编辑的信，标题为 "评估肝脏免疫状态指数在预测肝细胞癌患者术后预后方面的功效：多机构回顾性研究"。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-06 DOI: 10.1002/jhbp.12084

Ganesh Bushi, Muhammed Shabil, Amogh Verma

引用次数: 0

Reply to comment on "Evaluation of prognostic efficacy of liver immune status index in predicting postoperative outcomes in hepatocellular carcinoma patients: A multi-institutional retrospective study". 对 "评估肝脏免疫状态指数在预测肝细胞癌患者术后预后方面的功效：一项多机构回顾性研究"。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-05 DOI: 10.1002/jhbp.12085

Yuki Imaoka, Masahiro Ohira, Hideki Ohdan

引用次数: 0

Minimally invasive approach of hepatectomy and thrombectomy for hepatocellular carcinoma with right atrial tumor thrombus without sternotomy using percutaneous cardiopulmonary bypass. 利用经皮心肺旁路，在不进行胸骨切开术的情况下，对伴有右心房肿瘤血栓的肝细胞癌进行肝切除术和血栓切除术的微创方法。

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-03 DOI: 10.1002/jhbp.12083

Ryosuke Maki, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi

引用次数: 0

Prognostic significance of creatine kinase in resected pancreatic cancer. 切除胰腺癌肌酸激酶的预后意义

IF 3.2 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-11-03 DOI: 10.1002/jhbp.12081

Yuichiro Kohara, Satoshi Yasuda, Minako Nagai, Kota Nakamura, Yasuko Matsuo, Taichi Terai, Shunsuke Doi, Takeshi Sakata, Masayuki Sho

{"title":"Prognostic significance of creatine kinase in resected pancreatic cancer.","authors":"Yuichiro Kohara, Satoshi Yasuda, Minako Nagai, Kota Nakamura, Yasuko Matsuo, Taichi Terai, Shunsuke Doi, Takeshi Sakata, Masayuki Sho","doi":"10.1002/jhbp.12081","DOIUrl":"https://doi.org/10.1002/jhbp.12081","url":null,"abstract":"Background: Creatine kinase (CK) levels decrease with cancer progression and muscle wasting, but its association with pancreatic ductal adenocarcinoma (PDAC) remains unclear. The aim of this study was to investigate CK as a prognostic biomarker and surrogate marker for muscle mass in patients with PDAC.Methods: A retrospective analysis of 476 patients with PDAC was conducted. CK levels were categorized into low and high groups using receiver-operating characteristic (ROC) curve analysis.Results: Among the 476 patients, 200 (42.0%) and 276 (58.0%) were classified into the low and high CK groups, respectively. The low CK group had significantly poorer overall survival (p < .001) and recurrence-free survival (p < .001) compared to the high CK group. Multivariate analysis identified low CK as an independent poor prognostic factor (p < .001). The low CK group had significantly lower skeletal muscle index (p = .048) than the high CK group; however, the difference was slight and not significantly associated with sarcopenia. Additionally, combined risk assessment incorporating CK and resectability facilitated a more nuanced prognostic stratification.Conclusions: CK served as a reliable prognostic marker independent from resectability but was less effective as a marker for sarcopenia in PDAC.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0