Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study. 常温机器灌注与静态冷库在高meld受者DBD肝移植中的应用：一项单中心回顾性研究

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-05-08 DOI: 10.1002/jhbp.70129

Yuzuru Sambommatsu, Daisuke Imai, Kush Savsani, Mallika Datta, Junpei Tarashi, Jacob Hallesy, Samuel Wolfe, Isao Yokota, Seung Duk Lee, David A Bruno

{"title":"Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study.","authors":"Yuzuru Sambommatsu, Daisuke Imai, Kush Savsani, Mallika Datta, Junpei Tarashi, Jacob Hallesy, Samuel Wolfe, Isao Yokota, Seung Duk Lee, David A Bruno","doi":"10.1002/jhbp.70129","DOIUrl":"https://doi.org/10.1002/jhbp.70129","url":null,"abstract":"Background and purpose: While normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high-acuity recipients with high Model for End-Stage Liver Disease (MELD) scores, particularly using a back-to-base application model, is not well established. We aimed to compare short-term outcomes between NMP and SCS in this cohort.Methods: This retrospective cohort study analyzed 215 adult recipients with a laboratory MELD score ≥ 25 who underwent isolated liver transplantation from donation after brain death (DBD) donors between July 2022 and June 2024. Patients were divided into SCS (n = 137; median MELD, 35) and NMP (n = 78; median MELD, 36) groups. Outcomes were compared using multivariable regression analyses.Results: NMP was associated with higher daytime surgery rates (88.5% vs. 23.4%) and lower peak alanine aminotransferase levels (median 298 vs. 653 IU/L). However, no significant differences were found in blood loss, early allograft dysfunction, acute kidney injury, comprehensive complication index, hospital stay, or 90-day graft survival.Conclusions: In high-MELD recipients of DBD grafts, a predominantly back-to-base NMP approach did not improve major short-term clinical outcomes compared to SCS. Benefits of NMP appear to be highly context-dependent across three axes-graft type, application model (upfront vs. back-to-base), and recipient acuity.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study. 利用经乳头活检样本对胆道癌进行全面基因组分析的可行性：一项前瞻性研究。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-05-06 DOI: 10.1002/jhbp.70123

Kazuya Miyamoto, Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Hirohumi Inoue, Ryosuke Sato, Akihiro Matsumi, Yuki Fujii, Daisuke Uchida, Motoyuki Otsuka

{"title":"Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study.","authors":"Kazuya Miyamoto, Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Hirohumi Inoue, Ryosuke Sato, Akihiro Matsumi, Yuki Fujii, Daisuke Uchida, Motoyuki Otsuka","doi":"10.1002/jhbp.70123","DOIUrl":"https://doi.org/10.1002/jhbp.70123","url":null,"abstract":"Background: Patients with biliary tract cancer (BTC) often have actionable mutations, and comprehensive genomic profiling (CGP) plays an important role. However, the feasibility of CGP using transpapillary biopsy (TPB) samples remains unclear.Methods: Thirty patients with suspected BTC based on radiographic imaging were enrolled. Pre-analytical criteria for CGP suitability were based on the OncoGuide NCC Oncopanel System (NCCOP) and FoundationOne CDx (F1CDx). Each patient underwent six biopsies using an endoscopic introducer: five biopsy samples were preserved as formalin-fixed paraffin-embedded (FFPE) samples and one as a fresh frozen (FF) sample. DNA quality indicators were compared between the two groups.Results: Malignancy was confirmed in 29 patients, and one had a benign biliary stricture. Suitability rate was 31% (9/29) for NCCOP and 3.4% (1/29) for F1CDx. Compared to FFPE samples, FF samples demonstrated significantly higher DNA concentration [ng/μL, interquartile range (IQR)], [0.34 (0.16-0.95) vs. 37.8 (11.6-67.6), p < 0.001] and DNA integrity number (IQR) [7.1 (6.8-7.3) vs. 8.9 (8.3-9), p = 0.021].Conclusions: Introducer-assisted multipass TPB may increase the rate of obtaining adequate CGP specimens, but its suitability remains limited and strongly panel dependent. Since FF samples have better DNA quality, establishing a system detailing their use is desirable.Trial registration: ClinicalTrials.gov identifier: UMIN 000049826.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open Versus Laparoscopic and Robotic Approach in Hilar Cholangiocarcinoma: A Network Meta-Analysis With Trial Sequential Analysis. 开放、腹腔镜和机器人入路治疗肝门胆管癌：一项具有试验序列分析的网络荟萃分析。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-05-01 DOI: 10.1002/jhbp.70124

Fabio Giannone, Gabriela Del Angel Millan, Gianluca Cassese, Fabio Benedetti, Marco Palucci, Fabrizio Panaro

{"title":"Open Versus Laparoscopic and Robotic Approach in Hilar Cholangiocarcinoma: A Network Meta-Analysis With Trial Sequential Analysis.","authors":"Fabio Giannone, Gabriela Del Angel Millan, Gianluca Cassese, Fabio Benedetti, Marco Palucci, Fabrizio Panaro","doi":"10.1002/jhbp.70124","DOIUrl":"https://doi.org/10.1002/jhbp.70124","url":null,"abstract":"Background: The use of minimally invasive (MI) techniques for Hilar cholangiocarcinoma (HCCA) has increased in the last years, but high-quality evidence remains limited. This study aims to assess the safety of laparoscopic (LPS) and robotic (ROB) approaches compared to open surgery in the treatment of HCCA.Methods: After a systematic search, a frequentist network meta-analysis and a Trial sequential analysis were performed. Primary outcomes set for the study were major complications and R0 rate.Results: Fourteen studies including 1169 patients were found eligible, of which 403 were LPS (34.5%) and 137 operated with a ROB approach (11.7%). ROB and LPS techniques showed statistically similar rates of major complications (p = 0.251 and p = 0.143), while ROB was associated with a higher rate of negative resection margins (OR: 2.856, 95% CI: 1.585-5.144; p < 0.001). No differences were observed in the secondary outcomes assessed, except for the operative time, higher in both MI approaches, and length of stay, shorter in the ROB group.Conclusions: Global experience in MI surgery for HCCA remains limited and subject to potential bias. Nevertheless, both LPS and ROB approaches seem to represent safe and viable options for carefully selected patients when performed by experienced surgeons in high-volume centers.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Nanoliposomal Irinotecan Plus Fluorouracil/Leucovorin and S-1, Irinotecan, and Oxaliplatin as Second-Line Chemotherapy After Gemcitabine Plus Nab-Paclitaxel for Unresectable Pancreatic Cancer. 纳米脂质体伊立替康加氟尿嘧啶/亚叶酸蛋白与S-1、伊立替康和奥沙利铂作为吉西他滨加nab -紫杉醇后二线化疗治疗不可切除胰腺癌的比较

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-29 DOI: 10.1002/jhbp.70122

Masahiro Itonaga, Reiko Ashida, Takashi Tamura, Yasunobu Yamashita, Yuki Kawaji, Takahiro Shishimoto, Hiromu Morishita, Keisuke Hanada, Fumiyoshi Kojima, Masayuki Kitano

{"title":"Comparison of Nanoliposomal Irinotecan Plus Fluorouracil/Leucovorin and S-1, Irinotecan, and Oxaliplatin as Second-Line Chemotherapy After Gemcitabine Plus Nab-Paclitaxel for Unresectable Pancreatic Cancer.","authors":"Masahiro Itonaga, Reiko Ashida, Takashi Tamura, Yasunobu Yamashita, Yuki Kawaji, Takahiro Shishimoto, Hiromu Morishita, Keisuke Hanada, Fumiyoshi Kojima, Masayuki Kitano","doi":"10.1002/jhbp.70122","DOIUrl":"https://doi.org/10.1002/jhbp.70122","url":null,"abstract":"Objectives: The optimal second-line chemotherapy after gemcitabine plus nab-paclitaxel (GnP) for unresectable pancreatic cancer (PC) remains unclear. This study compared the efficacy and safety of nanoliposomal irinotecan plus fluorouracil/leucovorin (NFF) and S-1, irinotecan, and oxaliplatin (S-IROX) after GnP failure.Methods: This single-center retrospective cohort study included patients with unresectable PC refractory to GnP who received NFF or S-IROX between July 2020 and June 2024. Progression-free survival (PFS), overall survival (OS), tumor response, and adverse events were evaluated. Prognostic factors were also assessed with subgroup analyses.Results: Seventy-nine patients were analyzed (NFF, n = 55; S-IROX, n = 24). Median PFS was significantly longer with S-IROX than with NFF (6.29 vs. 3.45 months; p = 0.048), and the overall response rate was higher (29% vs. 9%; p = 0.038). Median OS did not differ significantly (12.81 vs. 10.64 months; p = 0.170). The incidence of grade ≥ 3 adverse events was comparable. Multivariate analysis identified S-IROX, modified Glasgow Prognostic Score (mGPS) 0, and CA19-9 < 373 IU/L as independent predictors of longer PFS, while mGPS 0 and CA19-9 < 373 IU/L were associated with longer OS. Subgroup analyses showed favorable outcomes with S-IROX in locally advanced disease.Conclusions: S-IROX may be an effective and safe second-line option after GnP, particularly for locally advanced PC.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Lymph Node Staging in Gallbladder Cancer: A Cutoff of 11 Nodes for Accurate Staging and Improved Survival. 优化胆囊癌淋巴结分期：切除11个淋巴结可准确分期并提高生存率。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-24 DOI: 10.1002/jhbp.70115

So Jeong Yoon, Hyun Jeong Jeon, Boram Park, Hyeong Seok Kim, Hochang Chae, Sang Hyun Shin, In Woong Han, Jin Seok Heo, Okjoo Lee, Hongbeom Kim

{"title":"Optimizing Lymph Node Staging in Gallbladder Cancer: A Cutoff of 11 Nodes for Accurate Staging and Improved Survival.","authors":"So Jeong Yoon, Hyun Jeong Jeon, Boram Park, Hyeong Seok Kim, Hochang Chae, Sang Hyun Shin, In Woong Han, Jin Seok Heo, Okjoo Lee, Hongbeom Kim","doi":"10.1002/jhbp.70115","DOIUrl":"https://doi.org/10.1002/jhbp.70115","url":null,"abstract":"Background: Gallbladder cancer (GBC) is an aggressive malignancy in which lymph node (LN) status is a key prognostic factor. Adequate LN retrieval is essential for accurate nodal staging. This study aimed to identify an LN threshold that reduces false node-negative (false N0) rates and to evaluate its association with overall survival (OS) as supportive evidence.Methods: This retrospective study included 425 patients in a development cohort and 176 patients in an external validation cohort who underwent curative-intent surgery for GBC between 2008 and 2017. False N0 rates were estimated according to the number of retrieved LNs using a β-binomial model, and survival analyses were performed as complementary assessments.Results: In both cohorts, retrieval of 11 LNs reduced the false N0 rate to approximately 11%-13% across T stages. Spline-based analyses demonstrated changes in survival patterns according to LN yield in the development cohort, with an inflection around 11 retrieved LNs, although dichotomized survival comparisons were not statistically significant in either cohort.Conclusions: Retrieval of at least 11 LNs was associated with a lower false N0 rate in GBC and may serve as a reference point for nodal staging. Survival analyses provided contextual support rather than evidence of a direct survival benefit.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stump Ischemia Is a Possible Risk Factor for Late-Onset Pancreatic Fistula After Distal Pancreatectomy. 残端缺血是远端胰腺切除术后迟发性胰瘘的可能危险因素。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-24 DOI: 10.1002/jhbp.70118

Shigeaki Kurihara, Kenjiro Kimura, Genki Watanabe, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Kohei Nishio, Hiroji Shinkawa, Takeaki Ishizawa

{"title":"Stump Ischemia Is a Possible Risk Factor for Late-Onset Pancreatic Fistula After Distal Pancreatectomy.","authors":"Shigeaki Kurihara, Kenjiro Kimura, Genki Watanabe, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Kohei Nishio, Hiroji Shinkawa, Takeaki Ishizawa","doi":"10.1002/jhbp.70118","DOIUrl":"https://doi.org/10.1002/jhbp.70118","url":null,"abstract":"Background: This study was conducted to determine the clinical significance of pancreatic stump ischemia (PSI) in predicting late-onset pancreatic fistula (LOPF) following stapled distal pancreatectomy (DP).Methods: A total of 165 patients who underwent stapled DP between July 2018 and March 2024 were included. PSI was defined as a non-enhancing area between the pancreatic stump and stapler line on postoperative contrast-enhanced computed tomography (CT). LOPF was diagnosed when peripancreatic fluid collection necessitated antibiotics and/or image-guided drainage after drain removal.Results: LOPF developed in 19 patients (11.5%). PSI was detected in 40 patients (24.2%) and was significantly more frequent in those with LOPF (47.4% vs. 21.2%). Receiver operating characteristic curve analysis identified a PSI width of ≥ 1.9 mm as the optimal threshold LOPF prediction. The incidence of LOPF was 26.5% among 81 patients with positive PSI (≥ 1.9 mm) on contrast-enhanced CT within 90 days postoperatively. By contrast, LOPF did not develop beyond 90 days following surgery, even when PSI was present.Conclusion: PSI may be interpreted as a radiologic factor associated with LOPF after stapled DP. Conservative drain management and close postoperative follow-up are recommended when an ischemic band ≥ 2 mm along a stapler line is detected on early postoperative CT.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologically Refined Oncological Resectability for Hepatocellular Carcinoma. 肝细胞癌的生物学精细化肿瘤可切除性。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-24 DOI: 10.1002/jhbp.70119

Kenta Aso, Yoshinori Takeda, Atsushi Takahashi, Shoichi Irie, Yoshihiro Hirata, Hirofumi Ichida, Ryuji Yoshioka, Yoshihito Kotera, Yoshihiro Mise, Akio Saiura

{"title":"Biologically Refined Oncological Resectability for Hepatocellular Carcinoma.","authors":"Kenta Aso, Yoshinori Takeda, Atsushi Takahashi, Shoichi Irie, Yoshihiro Hirata, Hirofumi Ichida, Ryuji Yoshioka, Yoshihito Kotera, Yoshihiro Mise, Akio Saiura","doi":"10.1002/jhbp.70119","DOIUrl":"https://doi.org/10.1002/jhbp.70119","url":null,"abstract":"Background/purpose: Oncological resectability criteria for hepatocellular carcinoma (HCC) have been proposed to guide multidisciplinary treatment, but their validation remains limited. Incorporating biological factors may improve prognostic stratification and identification of borderline-resectable HCC.Methods: Patients undergoing initial hepatectomy for HCC (2009-2022) were classified as resectable (R), borderline-resectable (BR)1, or BR2. Stratification of overall survival (OS) and recurrence-free survival (RFS) was compared with the BCLC staging system. R-group patients with alpha-fetoprotein (AFP) ≥ 400 ng/mL and des-gamma-carboxy prothrombin (DCP) ≥ 400 mAU/mL were subclassified as biological-BR.Results: Among 391 patients (R: 330; BR1: 23; BR2: 38), survival stratification was comparable to the BCLC classification. Twenty-six R-group patients were reclassified as biological-BR, with higher microvascular invasion rates (42.3%) and 5 year OS and 3 year RFS similar to BR1 patients (54.9% vs. 51.3%, p = 0.457; 38.1% vs. 25.0%, p = 0.954). Combining Biological BR with BR1 significantly improved time-dependent prediction of 6 month recurrence, with an area under the receiver operating characteristic curve (Refined: 0.803; Original: 0.658, p ≤ 0.001, BCLC: 0.608, p ≤ 0.001) and net reclassification improvement (0.220 vs. Original; 0.446 vs. BCLC).Conclusions: Refinement using AFP and DCP identified a biologically aggressive subset within the R group and may improve early recurrence prediction.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Middle Pancreatectomy for Low-Grade Malignancies: Superior Long-Term Glucose Tolerance Preservation Over Distal Pancreatectomy. 中端胰腺切除术治疗低级别恶性肿瘤：远端胰腺切除术优于长期糖耐量保存。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-23 DOI: 10.1002/jhbp.70121

Atsuro Fujinaga, Minoru Esaki, Kei Kitamura, Ryosuke Umino, Takahiro Mizui, Akinori Miyata, Satoshi Nara

{"title":"Middle Pancreatectomy for Low-Grade Malignancies: Superior Long-Term Glucose Tolerance Preservation Over Distal Pancreatectomy.","authors":"Atsuro Fujinaga, Minoru Esaki, Kei Kitamura, Ryosuke Umino, Takahiro Mizui, Akinori Miyata, Satoshi Nara","doi":"10.1002/jhbp.70121","DOIUrl":"https://doi.org/10.1002/jhbp.70121","url":null,"abstract":"Background: This study compared outcomes of middle pancreatectomy (MP) and distal pancreatectomy (DP), focusing on long-term glucose tolerance.Methods: We retrospectively reviewed 282 patients who underwent MP (n = 69) or DP (n = 213) for low-grade malignant tumors from 2000 to 2020. Surgical outcomes, HbA1c levels, prevalence of diabetes mellitus (DM), and escalation of antidiabetic medication were analyzed.Results: MP was associated with longer operation time (312 vs. 245 min, p < 0.001) and higher pancreatic fistula rate (64% vs. 47%, p = 0.018). Among 248 patients with 3-year follow-up, MP showed lower HbA1c levels (5.9% vs. 6.3%, p < 0.001), lower incidence of new-onset DM (3% vs. 30%, p < 0.001), and fewer cases of increased antidiabetic medication use (8% vs. 24%, p = 0.005). Insulin therapy was newly required in 1 MP case versus 18 DP cases.Conclusion: Despite higher morbidity, MP demonstrated superior preservation of long-term glucose tolerance compared with DP. These findings suggest that MP is a valuable parenchyma-preserving option for patients with low-grade malignant pancreatic tumors, particularly those at increased risk of postoperative DM, although careful consideration of surgical risks is required.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer. 自然牙数与后牙咬合对胰腺癌切除术预后的独立价值。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-23 DOI: 10.1002/jhbp.70113

Kaoru Seo, Kenichiro Uemura, Kenjiro Okada, Hiromi Nishi, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Yoshiaki Murakami, Hiroyuki Kawaguchi, Shinya Takahashi

{"title":"Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer.","authors":"Kaoru Seo, Kenichiro Uemura, Kenjiro Okada, Hiromi Nishi, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Yoshiaki Murakami, Hiroyuki Kawaguchi, Shinya Takahashi","doi":"10.1002/jhbp.70113","DOIUrl":"https://doi.org/10.1002/jhbp.70113","url":null,"abstract":"Background/purpose: Prognostic significance of preoperative patient-related factors, including oral health status, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We evaluated the association between preoperative factors-particularly oral health parameters-and long-term survival after curative PDAC resection.Methods: Patients who underwent radical pancreatectomy for PDAC (2014-2022) were retrospectively analyzed. Preoperative factors, including oral health status (natural tooth count and posterior teeth occlusion), clinical characteristics, and immuno-nutritional markers, were assessed for their association with overall survival (OS). Multivariate models adjusted for established pathological and treatment-related prognostic variables were further analyzed.Results: Of 343 eligible patients, 339 underwent preoperative dental examinations; 135 had ≤ 20 teeth and 204 had ≥ 21 teeth. Patients with ≤ 20 teeth had significantly poorer OS (median survival: 39.1 vs. 60.7 months, p < 0.001). Posterior teeth occlusion was not associated with OS. In multivariate analysis of preoperative factors, natural tooth count was independently associated with OS (p = 0.003). This association remained significant after adjustment for established prognostic variables (p = 0.016), whereas other immuno-nutritional markers did not emerge as independent prognostic factors.Conclusions: Post-PDAC resection, natural tooth count, but not posterior teeth occlusion, is independently associated with OS. Tooth count may reflect long-term host vulnerability and serve as a prognostic marker in PDAC patients.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological Complexity Determines the Frequency of Branching Variations in the Celiac Trunk-Superior Mesenteric Artery System. 拓扑复杂性决定了腹腔干-肠系膜上动脉系统分支变异的频率。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-04-23 DOI: 10.1002/jhbp.70120

Satoru Muro, Akimoto Nimura, Keiichi Akita

{"title":"Topological Complexity Determines the Frequency of Branching Variations in the Celiac Trunk-Superior Mesenteric Artery System.","authors":"Satoru Muro, Akimoto Nimura, Keiichi Akita","doi":"10.1002/jhbp.70120","DOIUrl":"https://doi.org/10.1002/jhbp.70120","url":null,"abstract":"Background: Variations in the anatomical branching patterns of the celiac trunk and superior mesenteric artery (SMA) directly affect vascular identification, surgical planning, and risk of intraoperative vascular injury. However, despite the extensive classification of these variations, the principles governing the occurrence of certain branching patterns remain unclear.Methods: We analyzed 28 branching subtypes of the celiac trunk-SMA system described by Adachi. Each branching pattern was quantified relative to the standard configuration by using Node-Shift (relative displacement of branching nodes), Edge-Gain (number of additional branches), and Edge-Loss (number of missing branches). The relationships between these topological parameters and branching frequency were examined using linear, log-linear, and exponential regression models.Results: Branching frequency consistently decreased as topological complexity increased. In subtypes without branch loss, the branching frequency showed a strong exponential decline with increasing Node-Shift and Edge-Gain (R2 = 0.979). When all subtypes were included, the exponential model maintained a similarly high explanatory power (R2 = 0.979), whereas the linear and log-linear models showed a limited fit. Branch loss was exclusively associated with very-low-frequency patterns.Conclusions: Arterial branching variations do not arise in a purely random manner and are consistent with the probabilistic constraints of developmental and anatomical pattern formation.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0