Characteristics and Outcomes of Declined Adult Liver Allografts due to Donor-Related Medical Reasons in Japan: Insights for Safe Utilization.

IF 2.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-09-23 DOI:10.1002/jhbp.70015

Junya Mita, Yusuke Takemura, Juntaro Ashikari, Kaori Kuramitsu, Shohei Yoshiya, Takeo Toshima, Shinji Itoh, Hiroto Egawa, Tomoharu Yoshizumi, Hiroyuki Yokota

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引用次数: 0

Abstract

Background: Few studies have evaluated allografts that were declined before the acceptance for deceased-donor liver transplantation. We aimed to elucidate the characteristics of these allografts and assess their transplantation outcomes.

Methods: We analyzed data from 730 adult liver allografts transplanted between July 2010 and March 2024. Clinical characteristics of the transplanted allografts were evaluated according to the number of declines, and the outcomes of the recipients were analyzed.

Results: Transplanted allografts were categorized into three groups: ≥ 5 declined (n = 41), 1-4 declined (n = 104), and no declined group (n = 585). The ≥ 5 declined group exhibited high liver enzyme levels and steatosis. Within this group, the Japan Risk Index and total ischemic time (TIT) were identified as poor prognostic factors. Notably, in cases where TIT exceeded 10 h, a poor prognosis was observed in the ≥ 5 declined group.

Conclusion: Abnormal liver functions or steatosis were observed in the ≥ 5 declined group. Shortening the TIT could contribute to an improved prognosis after transplantation.

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日本因供体相关医学原因导致成人同种异体肝脏移植减少的特点和结果：安全使用的见解

背景：很少有研究评估同种异体移植物在接受死亡供体肝移植之前的表现。我们的目的是阐明这些同种异体移植物的特点，并评估其移植结果。方法：我们分析了2010年7月至2024年3月期间移植的730例成人同种异体肝脏移植的数据。根据下降次数评估同种异体移植物移植的临床特征，并分析受者的结果。结果：移植同种异体移植物分为3组：≥5个衰退组（n = 41）， 1-4个衰退组（n = 104），无衰退组（n = 585）。≥5下降组表现为高肝酶水平和脂肪变性。在该组中，日本风险指数和总缺血时间（TIT）被确定为不良预后因素。值得注意的是，当TIT超过10 h时，≥5下降组的预后较差。结论：≥5衰组存在肝功能异常或脂肪变性。缩短TIT可以改善移植后的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY

自引率

10.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.