{"title":"The efficacy of 3D hologram support with mixed-reality technique in pancreatobiliary endoscopy.","authors":"Kazumasa Nagai, Maki Sugimoto, Takao Itoi, Hirohito Minami, Takayoshi Tsuchiya, Yoichi Araki, Ryosuke Tonozuka, Hiroyuki Kojima, Noriyuki Hirakawa, Shunichiro Orihara","doi":"10.1002/jhbp.12136","DOIUrl":"https://doi.org/10.1002/jhbp.12136","url":null,"abstract":"<p><strong>Background and aims: </strong>Mixed-reality (MR) technology is an advanced holographic imaging system that uses wearable devices to display three-dimensional (3D) images in clinical environments. In pancreatobiliary endoscopy, MR technology can facilitate 3D visualization of the bile and pancreatic ducts, enhancing spatial awareness and providing a more intuitive understanding of the anatomy. We evaluated the safety and efficacy of 3D hologram support (3D-HS) using MR in pancreatobiliary endoscopy.</p><p><strong>Methods: </strong>This study included 30 patients who underwent pancreatobiliary endoscopy using 3D-HS between June 2023 and July 2024. The procedures included ERCP (n = 13) and interventional EUS (iEUS) (n = 17). The primary outcome was technical success, with secondary outcomes including total procedure-related time and adverse events. The conventional treatment group, matched for age and disease type, was compared to the 3D-HS group. a questionnaire was used to evaluate the MR device, 3D hologram images, and the overall evaluation with 3D-HS.</p><p><strong>Results: </strong>The overall technical success rate was 96.7% (ERCP, 100%; iEUS, 93.8%). Adverse events occurred in 16.7% of cases; all were managed conservatively. comparison with conventional treatment showed no significant differences in outcomes, although conventional methods had shorter procedural times (p < 0.05). The questionnaire results indicated positive feedback on operability and image quality of 3D-HS, with enhanced anatomical understanding relative to 2D imaging, although some ERCP cases received lower ratings, particularly for intrahepatic bile duct stones.</p><p><strong>Conclusions: </strong>Pancreatobiliary endoscopy using 3D-HS can be safe and effective in enhancing anatomical understanding. Further studies are needed to optimize its use and reduce the total procedure time.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Augustin Meria, Anna Fournier, Thomas Chaigneau, Marietta Musikas, Marie Astrid Piquet, Benoît Dupont
{"title":"Prognostic value of the measurement at admission of the inferior vena cava in acute pancreatitis.","authors":"Augustin Meria, Anna Fournier, Thomas Chaigneau, Marietta Musikas, Marie Astrid Piquet, Benoît Dupont","doi":"10.1002/jhbp.12146","DOIUrl":"https://doi.org/10.1002/jhbp.12146","url":null,"abstract":"<p><strong>Background: </strong>Identifying new early predictive markers for the development of severe forms in acute pancreatitis remains a major challenge. The aim of this study was to evaluate the performance of inferior vena cava (IVC) measurement to predict severe acute pancreatitis.</p><p><strong>Methods: </strong>We conducted a single-center retrospective study including patients consecutively hospitalized for acute pancreatitis between 2014 and 2019 who had an abdominal scan within 24 h after admission, before any significant fluid resuscitation. We calculated the ratio of inferior vena cava diameters (IVCR) by dividing the transverse diameter by the anteroposterior. Admission parameters associated with the occurrence of severe acute pancreatitis (persistent organ failure or necrosis infection) were identified by multivariate logistic regression.</p><p><strong>Results: </strong>Of the 404 included patients, 64 (15.8%) progressed to severe pancreatitis. IVCR in these patients was significantly higher (2.2 ± 0.6 vs. 1.7 ± 0.9, p < .001). In multivariate analysis, IVCR was independently associated with severe pancreatitis (OR = 2.27 95% CI [1.38-3.72], p = .001), as well as visual analog scale, creatinine, albumin, and bicarbonates. The areas under the Receiver Operating Characteristic (ROC) curve of IVCR was 0.67, inferior to systemic inflammatory response syndrome (0.76; p = .03) and Bedside Index for Severe Acute Pancreatitis (BISAP) (0.80; p = .002) in predicting severe acute pancreatitis.</p><p><strong>Conclusions: </strong>IVCR is associated with the development of severe acute pancreatitis.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carbon-ion irradiation together with autophagy inhibition and immune checkpoint inhibitors protect against pancreatic cancer development in mouse model.","authors":"Makoto Sudo, Yaoyao Wang, Jingren Wang, Koubun Yasuda, Keiko Mitani, Shuhei Hayashi, Masaki Ohmuraya, Hiroko Tsutsui, Jiro Fujimoto","doi":"10.1002/jhbp.12148","DOIUrl":"https://doi.org/10.1002/jhbp.12148","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer remains fatal because of resistance to chemo-, radio-, and immunotherapies. Carbon-ion radiotherapy (CIRT) has been beneficial for patients with pancreatic cancer. The purpose of this study was to identify the mechanism by which CIRT exerts its anticancer activity, particularly in combination with immunotherapy.</p><p><strong>Methods: </strong>We implanted murine pancreatic cancer cells treated with CIRT and autophagy inhibitor HCQ (CIRT+HCQ) into syngeneic mice, followed by the application of a regulatory T (Treg) cell blockade using immune-checkpoint inhibitors. We compared CIRT+HCQ-treated tumors with those implanted without any treatment. Further, we also implanted CIRT+HCQ-treated pancreatic tumors into CD8<sup>+</sup> T cell-depleted mice. To characterize immunological alterations, we conducted immunohistology and flow cytometry of implanted tumors.</p><p><strong>Results: </strong>CIRT+HCQ-treated tumors exhibited reduced growth, higher numbers of CD8<sup>+</sup> T cells, and lower numbers of Treg cells compared with control tumors. CD8<sup>+</sup> T cell depletion restored growth in CIRT+HCQ-treated tumors. A Treg blockade resulted in greater tumor growth remission and elevated levels of intratumor CD8<sup>+</sup> T cells in mice bearing CIRT+HCQ-treated tumors but not in mice bearing control tumors.</p><p><strong>Conclusions: </strong>Treg cell-targeted therapy exerted an anticancer effect in mice bearing CIRT+HCQ-treated tumors but not in those bearing untreated pancreatic tumors by activating cancer-specific CD8<sup>+</sup> T cells.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical features and long-term prognosis of type 1 autoimmune pancreatitis based on the location of bile duct lesions.","authors":"Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Noriaki Gibo, Kunio Kataoka, Hiroshi Mori, Yoshihisa Takada, Hironori Aoi, Yoshiyuki Minami, Hiroki Kawashima","doi":"10.1002/jhbp.12147","DOIUrl":"https://doi.org/10.1002/jhbp.12147","url":null,"abstract":"<p><strong>Background/purpose: </strong>Type 1 autoimmune pancreatitis (AIP) frequently involves biliary lesions and poses diagnostic and therapeutic challenges. We aimed to evaluate the clinical features and long-term prognosis of type 1 AIP with a focus on the locations of bile duct lesions.</p><p><strong>Methods: </strong>In this retrospective study, 159 patients with type 1 AIP were included. Patients were classified on the basis of the location of bile duct strictures, and clinical outcomes, including relapse rates and steroid dependency, were analyzed.</p><p><strong>Results: </strong>Eighty-nine (56%) patients had bile duct involvement. Forty-nine patients (30.8%) experienced relapse, with a significantly higher cumulative relapse rate in cases of stricture or wall thickening upstream of the intrapancreatic bile duct (3 years: 24% vs. 37.1%, p < .001). These patients also had a significantly higher rate of two or more relapses than did the patients without stricture or wall thickening (5.1% vs. 19.5%, p = .01). Two patients with stricture and dilation up to the intrahepatic bile ducts became steroid-dependent and were treated with azathioprine.</p><p><strong>Conclusions: </strong>Patients with type 1 AIP with biliary lesions involving upstream strictures or wall thickening, especially those with stricture and dilation extending into the intrahepatic bile ducts, are at high risk of relapse and may become steroid dependent.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of the novel EUS scope and ultrasonographic system for diagnosis and therapy in patients with pancreatobiliary diseases (videos).","authors":"Hiroyuki Kojima, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Yukitoshi Matsunami, Hirohito Minami","doi":"10.1002/jhbp.12144","DOIUrl":"https://doi.org/10.1002/jhbp.12144","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the diagnostic and therapeutic capabilities of endoscopic ultrasonography (EUS) in pancreaticobiliary diseases. We aimed to validate the efficiency of detective flow imaging (DFI), shear wave elastography (SWE), and other advanced imaging techniques.</p><p><strong>Methods: </strong>We used new EUS scopes (EG-740 UT and G-580UR) and the latest ultrasound equipment (ARIETTA 850) (Fujifilm Healthcare, Kanagawa, Japan). Diagnostic procedures were performed in 16 cases, including pancreatic cancer and intraductal papillary mucinous neoplasms, and therapeutic procedures in eight cases, involving complex biliary and pancreatic interventions. The utility of SWE in assessing tissue stiffness was quantified by measuring the shear wave velocity (SWV) in pancreatic cancer and autoimmune pancreatitis.</p><p><strong>Results: </strong>We found no significant difference in SWVs among different pancreatic conditions; however, significant variations were observed in the net percentage of effective SWV. Interventional EUS had a 100% technical and clinical success rate, demonstrating the efficacy of new imaging techniques and equipment in enhancing procedural safety and diagnostic accuracy.</p><p><strong>Conclusions: </strong>The integration of advanced EUS imaging technologies, particularly DFI, contrast-enhanced EUS, and SWE, significantly enhances the diagnosis and treatment of pancreaticobiliary diseases.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new framework for tailoring laparoscopic cholecystectomy: Integrating preoperative clinical factors with surgical difficulty based on the Tokyo Guidelines 2018.","authors":"Daisuke Noguchi, Aoi Hayasaki, Takahiro Ito, Yusuke Iizawa, Takehiro Fujii, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno","doi":"10.1002/jhbp.12145","DOIUrl":"https://doi.org/10.1002/jhbp.12145","url":null,"abstract":"<p><strong>Purpose: </strong>The Tokyo Guidelines 2018 introduced the Surgical Difficulty Score (TGDS18) to assess laparoscopic cholecystectomy (LC) difficulty based on intraoperative findings. This study aimed to predict surgical difficulty preoperatively using clinical factors correlated with TGDS18.</p><p><strong>Methods: </strong>Of 369 LC cases for cholecystitis (Jan 2014-Jul 2024), 106 with operative video data were analyzed. Multivariate analysis of 69 with preoperative CT (≤14 days) evaluated the association between preoperative clinical findings and TGDS18 sub-scores (around the gallbladder, Calot's triangle, gallbladder bed, additional findings, unrelated to inflammation).</p><p><strong>Results: </strong>TGDS18 was positively correlated with operative time, blood loss, and hospital stay (all p < .001). Patients undergoing subtotal cholecystectomy had higher TGDS18 scores (median 20, p < .001). Six preoperative findings strongly associated with TGDS18 sub-scores were identified: calcified stone in cystic duct, TG18 Grade ≥2, preoperative gallbladder drainage, urgent operation, pericholecystic inflammation, and age-adjusted Charlson comorbidity index ≥7. The rate of subtotal cholecystectomy increased with the number of findings linked to the \"Calot's triangle\" sub-score-cystic duct stone and TG18 Grade ≥2. (0% with no findings, 8% with one finding, and 23% with both, p = .009). Similarly, the risk of cholecystectomy requiring the posterior wall left can be predicted by the number of clinical findings related to the 'Gallbladder bed' sub-score (p = .009).</p><p><strong>Conclusions: </strong>The clinical findings linked to TGDS18 allow tailored preoperative strategies for acute cholecystitis.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael J Kirsch, Salvador Rodriguez Franco, Toshitaka Sugawara, Oskar Franklin, Richard D Schulick, Marco Del Chiaro
{"title":"Frozen section pathology in IPMN: A systematic review.","authors":"Michael J Kirsch, Salvador Rodriguez Franco, Toshitaka Sugawara, Oskar Franklin, Richard D Schulick, Marco Del Chiaro","doi":"10.1002/jhbp.12126","DOIUrl":"https://doi.org/10.1002/jhbp.12126","url":null,"abstract":"<p><p>Intraductal papillary mucinous neoplasms (IPMNs) resection margins are assessed intraoperatively using frozen section (IFS) pathology. We conducted a systematic review to evaluate the concordance of IFS with permanent histopathology and the association between IFS margin status and recurrence. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We queried PubMed, Embase, Scopus, and Google Scholar for studies reporting IFS in patients undergoing resection for IPMN. Data, including IFS margin status, recurrence rates, and final pathology, were extracted. Positive margins were defined as high-grade dysplasia or invasive cancer. Seven studies, with a total of 706 patients, met the inclusion criteria. Positive IFS margins were reported in 9.4% of cases, with a high correlation (98%) between IFS and final pathology. Recurrence occurred in 15.4% of patients. Fifty-nine of 85 (69.4%) patients with recurrence of IPMN or intraductal papillary mucinous carcinoma (IPMC) had negative IFS margins. IFS accurately predicts final pathology and is a valuable tool for guiding intraoperative decision-making. A sizeable number of patients experienced recurrence despite negative margins, highlighting the need for adjunct diagnostic modalities and continued surveillance following resection, regardless of margin status.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic yields and clinical impact of endoscopic ultrasound-guided tissue acquisition for biliary lesions.","authors":"Daiki Agarie, Susumu Hijioka, Yoshikuni Nagashio, Daiki Yamashige, Kohei Okamoto, Shin Yagi, Soma Fukuda, Shota Harai, Kazuko Yamamoto, Takuji Okusaka","doi":"10.1002/jhbp.12143","DOIUrl":"https://doi.org/10.1002/jhbp.12143","url":null,"abstract":"<p><strong>Background/purpose: </strong>Diagnostic yields of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for biliary lesions have not been fully established due to limited evidence. We aimed to clarify the efficacy of EUS-TA for biliary lesions.</p><p><strong>Methods: </strong>Diagnostic yields and adverse event rates of EUS-TA for biliary lesions were evaluated. The subject cases were only limited to cases in which the biliary lesions itself was punctured. Diagnostic yields of endoscopic retrograde cholangiography (ERC)-guided biopsy/cytology performed within the same period were also evaluated to assess the additional effect of EUS-TA.</p><p><strong>Results: </strong>EUS-TA was attempted in 71 cases (28 hilar bile duct, 19 distal bile duct, 4 ampulla of Vater, and 20 gallbladder), and the final diagnosis was malignant in 54 cases (76.1%). The sensitivity, specificity, and accuracy of EUS-TA were 96.3% (52/54), 100% (17/17), and 97.2% (69/71), respectively. Adverse events were observed in one case (1.4%, peritonitis). The accuracy of ERC biopsy/cytology was 82.5% (212/257 cases); additional EUS-TA diagnosed 30 cases as malignant additionally and improved the accuracy (94.2%; 242/257 cases; p < .01).</p><p><strong>Conclusions: </strong>EUS-TA is an accurate and safe diagnostic test for biliary lesions. The addition of EUS-TA may be considered when there is a suspicion of a false-negative ERC result.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}