Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献_第2页

"How I Do It:" Robotic Transduodenal Ampullectomy for an Ampullary Adenoma. 我是怎么做的：机器人经十二指肠壶腹切除术治疗壶腹腺瘤。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-29 DOI: 10.1002/jhbp.70002

Juan Felipe Salazar Gonzalez, Daniel Aliseda, Jon Michael Harrison, Brendan Christopher Visser

引用次数: 0

Incidence and Risk Factors for Prolonged Opioid Analgesic Use in Opioid-Naive Patients Following Pancreaticoduodenectomy. 胰十二指肠切除术后阿片类药物初治患者阿片类药物长期使用的发生率和危险因素。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-25 DOI: 10.1002/jhbp.70007

Fang-Ju Hsueh, Jin-Ming Wu, Chien-Hui Wu, Ting-Chun Kuo, Ching-Yao Yang, Kuang-Cheng Chan, Yu-Wen Tien

{"title":"Incidence and Risk Factors for Prolonged Opioid Analgesic Use in Opioid-Naive Patients Following Pancreaticoduodenectomy.","authors":"Fang-Ju Hsueh, Jin-Ming Wu, Chien-Hui Wu, Ting-Chun Kuo, Ching-Yao Yang, Kuang-Cheng Chan, Yu-Wen Tien","doi":"10.1002/jhbp.70007","DOIUrl":"https://doi.org/10.1002/jhbp.70007","url":null,"abstract":"Background: Effective pain management is essential for patients undergoing pancreaticoduodenectomy (PD) due to the complexity of the surgery. Opioid analgesics (OA) are commonly used for pain relief but can lead to prolonged postoperative use, posing significant health risks. This study examines the incidence and risk factors of prolonged OA use among opioid-naive patients following PD.Methods: This retrospective cohort study included patients who underwent PD from 2010 to 2022 at National Taiwan University Hospital, excluding those with preoperative opioid use, emergent PD, minimally invasive procedures, opioid dependence, or in-hospital death. Prolonged OA use was defined as filling at least one OA prescription between 31 and 60 days postoperatively. Statistical analyses included univariate and multivariate logistic regression models to identify risk factors.Results: Among the 1309 patients, 224 (17.1%) filled at least one OA prescription between 31 and 60 days after PD. Multivariate analysis identified BMI (OR = 1.06, 95% CI = 1.02-1.10, p = 0.001), chronic pancreatitis (OR = 1.82, 95% CI = 1.13-2.94, p = 0.013), and epidural analgesia use (OR = 2.40, 95% CI = 1.64-3.52, p < 0.001) as factors associated with prolonged OA use.Conclusion: This study reveals a 17.1% incidence of prolonged OA use among opioid-naive patients post-PD. These findings highlight the need for tailored pain management strategies to reduce prolonged opioid use and improve patient outcomes. Further research should focus on developing targeted interventions to mitigate opioid dependency in this population.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Impact of HER2 Overexpression in Intraductal Papillary Neoplasm of the Bile Duct. HER2过表达对胆管内乳头状肿瘤预后的影响。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-25 DOI: 10.1002/jhbp.70000

Shunsuke Onoe, Takashi Mizuno, Nobuyuki Watanabe, Shoji Kawakatsu, Junpei Yamaguchi, Taisuke Baba, Ryusei Yamamoto, Yoshie Shimoyama, Toshio Kokuryo, Tomoki Ebata

{"title":"Prognostic Impact of HER2 Overexpression in Intraductal Papillary Neoplasm of the Bile Duct.","authors":"Shunsuke Onoe, Takashi Mizuno, Nobuyuki Watanabe, Shoji Kawakatsu, Junpei Yamaguchi, Taisuke Baba, Ryusei Yamamoto, Yoshie Shimoyama, Toshio Kokuryo, Tomoki Ebata","doi":"10.1002/jhbp.70000","DOIUrl":"https://doi.org/10.1002/jhbp.70000","url":null,"abstract":"Background: Overexpression of human epidermal growth factor receptor 2 (HER2) is a recognized prognostic marker and therapeutic target in oncology. However, its clinical significance in intraductal papillary neoplasm of the bile duct (IPNB) remains unclear.Methods: This retrospective study reviewed patients who underwent resection for IPNB between 1998 and 2011. HER2 overexpression was evaluated by immunohistochemistry and semi-quantitatively categorized into four grades (score 0, 1+, 2+, 3+); the former two and the latter two grades defined HER2-negative and HER2-positive groups, respectively.Results: A total of 184 IPNB cases were analyzed, of which 12 patients (6.5%) were diagnosed with HER2-positive disease. There were no significant differences between the groups in clinicopathologic characteristics such as tumor location, histologic type, or invasion depth, with the exception of superficial extension, which was significantly more frequent in the HER2-positive group. The HER2-positive group demonstrated significantly worse overall survival than the HER2-negative group (25% vs. 49% at 5 years, p = 0.030). In multivariable analysis, HER2 positivity, age ≥ 70, percutaneous transhepatic biliary drainage, nodal metastasis, and positive margin status were identified as independent prognostic factors.Conclusion: HER2 overexpression is an independent biologic marker for unfavorable survival, though infrequent in IPNB.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of New Portal Reconstruction Strategy on Portal Vein Growth and Outcomes in Living-Donor Liver Transplantation for Small Children With Biliary Atresia. 新的门静脉重建策略对胆道闭锁儿童活体肝移植门静脉生长和预后的影响。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-24 DOI: 10.1002/jhbp.70003

Hikaru Aoki, Eri Ogawa, Takashi Ito, Elena Yukie Uebayashi, Shinya Okumura, Yuki Masano, Tatsuya Okamoto, Hironori Haga, Hideaki Okajima, Etsuro Hatano

{"title":"Impact of New Portal Reconstruction Strategy on Portal Vein Growth and Outcomes in Living-Donor Liver Transplantation for Small Children With Biliary Atresia.","authors":"Hikaru Aoki, Eri Ogawa, Takashi Ito, Elena Yukie Uebayashi, Shinya Okumura, Yuki Masano, Tatsuya Okamoto, Hironori Haga, Hideaki Okajima, Etsuro Hatano","doi":"10.1002/jhbp.70003","DOIUrl":"https://doi.org/10.1002/jhbp.70003","url":null,"abstract":"Background/purpose: We evaluated the outcomes of a new reconstruction method that we adopted in 2017 for small children with biliary atresia, involving aggressive resection of the sclerotic portal vein (PV), larger anastomotic orifice, and proactive vein graft interposition.Methods: Data from 85 patients with biliary atresia (excluding one) aged < 3 years who underwent living-donor liver transplantation from January 2011 to December 2022 were retrospectively reviewed. Patients were categorized into former (\"before 2017\") and latter (\"after 2017\") groups, comprising 47 and 38 patients, respectively, according to their surgery time.Results: The percentage of trunk reconstruction cases decreased from 51% to 26%, whereas that of vein graft interposition cases increased from 38% to 68% (p = 0.021). PV complication rates improved significantly from 19% to 3% (p = 0.035). Over 6 months postoperatively, the PV diameter was < 6 mm in 44% of cases in the former group but improved to 0% in the latter group (p < 0.01). Platelet counts at 1 year postoperatively were significantly higher in the latter group.Conclusions: In living-donor liver transplantation for small children with biliary atresia, aggressive resection of the sclerotic PV, large anastomotic orifice, and proactive vein graft interposition may reduce PV complications and provide appropriate portal dilation for body growth.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Surgical Technique of Liver Parenchyma Transection During Robotic-Assisted Liver Resection: "Trac & Pac". 机器人辅助肝切除术中肝实质横断的新手术技术：“Trac & Pac”。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-22 DOI: 10.1002/jhbp.70006

Yuta Abe, Yutaka Nakano, Yosuke Uematsu, Minoru Kitago, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Taizo Hibi, Yuko Kitagawa

{"title":"Novel Surgical Technique of Liver Parenchyma Transection During Robotic-Assisted Liver Resection: \"Trac & Pac\".","authors":"Yuta Abe, Yutaka Nakano, Yosuke Uematsu, Minoru Kitago, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Taizo Hibi, Yuko Kitagawa","doi":"10.1002/jhbp.70006","DOIUrl":"https://doi.org/10.1002/jhbp.70006","url":null,"abstract":"Background/purpose: A standardized liver parenchymal transection method in robotic-assisted liver resection has not yet been established, and the techniques used vary among institutions. We developed a novel transection technique for robotic-assisted liver resection termed \"Trac & Pac,\" which uses maryland bipolar forceps with a gentle stroking motion and strategic traction to progressively expose and dissect the liver parenchyma.Methods: We described the technical details of \"Trac & Pac\" and Evaluated its short-term outcomes (2022-2025), comparing them with those of conventional laparoscopic liver resection using the Cavitron Ultrasonic Surgical Aspirator (CUSA) (2018-2022).Results: The robotic-assisted liver resection group included 26 patients who underwent robotic left or right hepatectomy with the \"Trac & Pac\" technique, whereas the laparoscopic liver resection group comprised 34 patients who underwent laparoscopic left or right hepatectomy using the CUSA. The robotic group had a longer time from pneumoperitoneum to the start of intra-abdominal manipulation than the laparoscopic group (p < 0.001). Both groups had similar parenchymal transection times, blood loss, and postoperative complications.Conclusions: \"Trac & Pac\" is a safe and feasible robotic-assisted liver parenchymal transection technique that may provide a new solution for improving precision and exposure in minimally invasive liver surgery.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Closure of an Enterocutaneous Fistula Associated With Surgical Site Infection After Pancreatoduodenectomy Using an Over-the-Scope Clip System. 使用超镜夹系统成功关闭胰十二指肠切除术后与手术部位感染相关的肠皮瘘。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-20 DOI: 10.1002/jhbp.70005

Sho Hasegawa, Itaru Endo, Masato Yoneda

引用次数: 0

Comprehensive Analysis of Chyle Leak in Resected Pancreatic Head Cancer: Impact on Clinical, Oncologic, and Nutritional Outcomes. 胰头癌切除术后乳糜漏的综合分析：对临床、肿瘤学和营养结果的影响。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-13 DOI: 10.1002/jhbp.12191

Jae Seung Kwak, Chang Moo Kang, Ho Kyoung Hwang, Sung Hyun Kim, Seung Soo Hong

{"title":"Comprehensive Analysis of Chyle Leak in Resected Pancreatic Head Cancer: Impact on Clinical, Oncologic, and Nutritional Outcomes.","authors":"Jae Seung Kwak, Chang Moo Kang, Ho Kyoung Hwang, Sung Hyun Kim, Seung Soo Hong","doi":"10.1002/jhbp.12191","DOIUrl":"https://doi.org/10.1002/jhbp.12191","url":null,"abstract":"Background: Chyle leak (CL) is a relevant complication of pancreatic surgery, but its incidence, risk factors, clinical and oncologic impacts, and nutritional relevance remain inconsistent and limited.Methods: We retrospectively reviewed patients who underwent pancreaticoduodenectomy for pancreatic head cancer from 2007 to 2023 at a single institution. The clinical impact of CL was evaluated by prolonged hospital stays and immune-nutritional status, assessed using the Controlling Nutritional Status (CONUT) score at discharge. Oncologic impact included the administration of adjuvant chemotherapy, the surgery-to-chemotherapy interval, overall survival (OS), and recurrence-free survival (RFS). Predictors of CL were identified through multivariate analyses.Results: CL occurred in 70 patients (13.8%) and was significantly associated with prolonged hospital stay (OR: 1.947, p = 0.045) and poor CONUT score at discharge (> 6; OR: 1.820, p = 0.036). CL did not significantly impact oncologic outcomes, including adjuvant chemotherapy (p = 0.732), surgery-to-chemotherapy interval (p = 0.235), 5-year OS (p = 0.978), or 5-year RFS (p = 0.919). Independent predictors of CL included hypertension, lymph node metastasis, delayed gastric emptying, minimally invasive surgery (MIS), and operative time.Conclusions: CL is associated with prolonged hospital stay and poor nutritional status at discharge, but shows no significant impact on long-term oncologic outcomes.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter to the Editor. 对给编辑的信的回应。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-06 DOI: 10.1002/jhbp.12185

Kazumasa Nagai, Takao Itoi

引用次数: 0

Microbiological Characteristics of Pathogens Isolated From Blood Cultures of Patients With Acute Cholangitis: Insights From Patients With Biliary-Enteric Anastomosis. 急性胆管炎患者血培养病原菌的微生物学特征：来自胆肠吻合患者的见解。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-02 DOI: 10.1002/jhbp.12193

Yuta Kuhara, Hiroki Kitagawa, Yuki Kaiki, Keitaro Omori, Norifumi Shigemoto, Tomoyuki Akita, Kenichiro Uemura, Shingo Fukuma, Shinya Takahashi, Hiroki Ohge

{"title":"Microbiological Characteristics of Pathogens Isolated From Blood Cultures of Patients With Acute Cholangitis: Insights From Patients With Biliary-Enteric Anastomosis.","authors":"Yuta Kuhara, Hiroki Kitagawa, Yuki Kaiki, Keitaro Omori, Norifumi Shigemoto, Tomoyuki Akita, Kenichiro Uemura, Shingo Fukuma, Shinya Takahashi, Hiroki Ohge","doi":"10.1002/jhbp.12193","DOIUrl":"https://doi.org/10.1002/jhbp.12193","url":null,"abstract":"Background: We aimed to investigate the microbiological characteristics of pathogens isolated from blood cultures (BCs) of patients with acute cholangitis (AC) after biliary-enteric anastomosis and biliary intervention (BI).Methods: A retrospective analysis was conducted on 366 patients with AC and bacteremia between 2015 and 2024 at Hiroshima University Hospital. Patients were categorized into three groups: post-biliary reconstruction-associated AC (PBR-AC), BI-associated AC (BI-AC), and common AC (C-AC). Patients' clinical and microbiological data were statistically analyzed in each group.Results: The most frequently isolated pathogens were Escherichia coli and Klebsiella spp., accounting for > 50% of isolates in all groups. ESCPM spp. (Enterobacter spp., including Klebsiella aerogenes, Serratia marcescens, Citrobacter freundii complex, Providencia spp., and Morganella morganii) were significantly associated with PBR- and BI-AC compared with C-AC. No significant differences in the prevalence of anaerobic bacteria were observed among the groups.Conclusions: The prevalence of ESCPM spp. isolated from BCs was significantly higher in the PBR- and BI-AC groups than in the C-AC group. The presence of biliary-enteric anastomosis or BI history should be checked when determining the treatment strategy for AC. Cefepime may be a better antibiotic option for PBR- and BI-AC, particularly in severe cases.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Patients With Unresectable Cholangiocarcinoma After Portal Vein Embolization: A Propensity Score-Matched Analysis. 门静脉栓塞后不可切除胆管癌患者的预后：倾向评分匹配分析。

IF 2.8 3区医学

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2025-08-01 DOI: 10.1002/jhbp.12192

Ho Seung Lee, Tae Jun Song, Sung Hyun Cho, Gunn Huh, Dongwook Oh, Jae Min Lee, Jae Hoon Lee, Dae Wook Hwang, Dong-Wan Seo

{"title":"Outcomes of Patients With Unresectable Cholangiocarcinoma After Portal Vein Embolization: A Propensity Score-Matched Analysis.","authors":"Ho Seung Lee, Tae Jun Song, Sung Hyun Cho, Gunn Huh, Dongwook Oh, Jae Min Lee, Jae Hoon Lee, Dae Wook Hwang, Dong-Wan Seo","doi":"10.1002/jhbp.12192","DOIUrl":"https://doi.org/10.1002/jhbp.12192","url":null,"abstract":"Background: This study aimed to evaluate the outcomes of patients with unresectable cholangiocarcinoma (CCA) who underwent portal vein embolization (PVE) with a focus on overall survival (OS) and the frequency of biliary drainage (BD).Methods: In this retrospective analysis, we evaluated 255 patients with unresectable CCA; 56 patients underwent PVE but ultimately remained unresectable. Propensity score matching (PSM) was used to minimize the potential confounding factors. The primary outcome was the OS, while the secondary outcome was BD frequency.Results: The PVE-unresectable group showed lower OS than that in the non-PVE-unresectable group both before and after PSM (median OS: 238.5 vs. 371.0 days, p = 0.006; 238.5 vs. 483.5 days, p = 0.002, respectively). Unresectable PVE status was a predictor of worse survival both before and after PSM (hazard ratio [HR] = 2.06, p < 0.001 and HR = 2.46, p < 0.001, respectively). Chemotherapy improved survival before and after PSM (HR = 0.45, p < 0.001 and HR = 0.41, p = 0.003, respectively). The BD frequency was higher in the PVE-unresectable group than in the non-PVE-unresectable group before and after PSM (0.693 vs. 0.470 procedures per month, p = 0.010).Conclusions: Patients with unresectable CCA who underwent PVE had worse survival outcomes and required BD. Optimizing systemic therapy and BD strategies may improve the outcomes.","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0