Journal of Hypertension最新文献

{"title":"Transcriptomic analysis identifies novel ferroptosis-related biomarkers and therapeutic targets in pulmonary arterial hypertension.","authors":"Haoyi Ji, Shuangshuang Ma, Wenhui Bao, Xincheng Li, Xinfang Li, Yu Du, Liu Liu, Yiwei Shi, Yishan Li","doi":"10.1097/HJH.0000000000004374","DOIUrl":"10.1097/HJH.0000000000004374","url":null,"abstract":"<p><strong>Background: </strong>Ferroptosis plays a significant role in pulmonary arterial hypertension (PAH), although its underlying mechanisms and key pathogenic genes remain unclear.</p><p><strong>Methods: </strong>Transcriptomic data from human PAH and control lung tissue were obtained from the Gene Expression Omnibus (GEO) database, whereas ferroptosis-related genes (FRGs) were sourced from the MsigDb and FerrDb databases. Differentially expressed FRGs (DE-FRGs) were identified through the intersection of FRGs with differentially expressed genes (DEGs). Functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Key hub genes were identified through Least Absolute Shrinkage and Selection Operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and weighted correlation network analysis (WGCNA). Gene set enrichment analysis (GSEA) was conducted to explore the functional roles and associated pathways of hub genes. The relationship between hub genes and immune infiltration was investigated. Expression levels of potential biomarkers were validated via Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) in two PAH animal models (monocrotaline-induced and Sugen5416 plus hypoxia-induced PAH). Finally, molecular docking was employed to screen potential therapeutic compounds.</p><p><strong>Results: </strong>A total of 133 DE-FRGs were identified, with KEGG and GO analyses highlighting their involvement in intracellular iron homeostasis and ferroptosis. Hub genes, notably FZD7 and NFE2, were identified using LASSO, SVM-RFE, and WGCNA. Immune infiltration analysis suggested that monocytes and neutrophils play key roles in PAH pathogenesis. Validation in PAH animal models showed significant upregulation of Fzd7 and downregulation of Nfe2 in lung tissues of both MCT- and SuHx-induced PAH models. Molecular docking identified tetrachlorodibenzodioxin (TCDD) has good binding affinity.</p><p><strong>Conclusion: </strong>In summary, we investigated two ferroptosis-related biomarkers, FZD7 and NFE2, in PAH using transcriptomics, offering new insights into molecular mechanisms and potential targeted therapies for the disease.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1564-1578"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response effects of isometric wall squats on postexercise hypotension in older women with hypertension.","authors":"Milton Rocha Moraes, Angélica Ramos Aranha, Erisvaldo Silva, Bernardo Neme Ide, Marcos Doederlein Polito, Rodrigo Vanerson Passos Neves, Hugo de Luca Corrêa, Alexandre Sérgio Silva, Herbert Gustavo Simões, Antonio R Zamuner, Fernando Ribeiro, Linda S Pescatello, Sandro Soares Almeida, Thiago Dos Santos Rosa, Luiz Humberto Rodrigues Souza","doi":"10.1097/HJH.0000000000004381","DOIUrl":"10.1097/HJH.0000000000004381","url":null,"abstract":"<p><strong>Objectives: </strong>The isometric wall squat (IWS) is a promising nonpharmacological intervention for blood pressure (BP) management, but its optimal dosage in older adults remains unclear. This study compared postexercise hypotension (PEH) after two IWS doses in medicated older women with systemic arterial hypertension (SAH).</p><p><strong>Methods: </strong>Thirty older hypertensive women (68.8 ± 10.0 years) were randomized into three groups: control (CG), 8-min IWS (G8-IWS; 4 × 2-min sets), and 12-min IWS (G12-IWS; 6 × 2-min sets). BP and heart rate (HR) were assessed at rest and at 0, 5, 10, 15, 30, 45, and 60 min postexercise and analyzed using linear mixed-effects models with Bonferroni correction ( P  < 0.05).</p><p><strong>Results: </strong>G12-IWS significantly reduced systolic BP and mean arterial pressure (MAP) at 45-60 min and 30-60 min postexercise ( P  < 0.05), while G8-IWS showed no BP changes. G12-IWS decreased HR (30-60 min) and rate-pressure product (RPP; 15-60 min); G8-IWS reduced RPP from 30 to 60 min only. Diastolic BP and pulse pressure remained unchanged in both groups.</p><p><strong>Conclusion: </strong>A single G12-IWS session induced clinically meaningful PEH (~8-10 mmHg), exceeding reported with isometric handgrip exercise (~4-6 mmHg), with greater RPP suppression than G8-IWS. This equipment-free protocol represents a relevant nonpharmacological strategy for BP management in older women with SAH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1626-1635"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vascular features enhance short-term prediction of delivery in hypertensive disorders of pregnancy.","authors":"Mingsi Chi, Jiawei Tang, Shuangyong Wang, Di Xiao, Yu Huang, Liang Hong, Dunjin Chen, Ying Cui, Fang He","doi":"10.1097/HJH.0000000000004369","DOIUrl":"10.1097/HJH.0000000000004369","url":null,"abstract":"<p><strong>Objective: </strong>Hypertensive disorders of pregnancy (HDP) are a significant global health concern requiring effective strategies for risk stratification. We hypothesized that integrating quantitative retinal vascular features with the soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio and clinical data would significantly improve the prediction of delivery within 2 weeks due to HDP progression.</p><p><strong>Method: </strong>This prospective cohort study enrolled 54 hospitalized patients with HDP who underwent simultaneous sFlt-1/PlGF testing and fundus photography. Retinal vascular parameters (density, fractal dimension, tortuosity) were automatically quantified from images using the deep-learning-based AutoMorph pipeline, with separate analyses performed for arteries and veins. The primary outcome was delivery for maternal or fetal indications within 2 weeks. Predictive models were developed and compared using logistic regression with feature selection.</p><p><strong>Results: </strong>Patients with an sFlt-1/PlGF ratio at least 38 exhibited significant retinal microvascular alterations, including reduced vessel density and fractal dimension, compared to those with a lower ratio. These changes were more pronounced in patients who progressed to preeclampsia. The full multimodal model, incorporating retinal features, the sFlt-1/PlGF ratio, and clinical data, achieved an area under the curve (AUC) of 0.85 [95% conflicts of interest (CI), 0.75-0.96)] for predicting delivery within 2 weeks. This significantly outperformed models based on the sFlt-1/PlGF ratio alone (AUC = 0.64) or the ratio combined with clinical data (AUC = 0.72).</p><p><strong>Conclusion: </strong>The integration of retinal vascular features with clinical and biochemical data may improve predictive performance of short-term risk stratification in HDP. This non-invasive, multimodal approach warrants validation in larger prospective studies to determine its potential for improving clinical decision-making.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1556-1563"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of systemic microvascular function in the association between large artery stiffness and cognitive function in older adults.","authors":"Kunihiko Aizawa, Kim M Gooding, Francesco Casanova, David J Llewellyn, Andrew Forbes Brown, Natalia Rolinska, Anna Barnes, Damilola D Adingupu, David M Mawson, Phillip E Gates, Suzy V Hope, Mark Gilchrist, W David Strain, Angela C Shore","doi":"10.1097/HJH.0000000000004368","DOIUrl":"10.1097/HJH.0000000000004368","url":null,"abstract":"<p><strong>Objectives: </strong>We determined whether large artery stiffness (LAS) and systemic microvascular function were associated with cognitive function in older adults, and whether systemic microvascular function mediated the association between LAS and cognitive function.</p><p><strong>Methods: </strong>Older adults with diverse cardiovascular risk ( n  = 435, 162F) participated in this study. Estimated pulse wave velocity (ePWV) as an estimate of LAS was calculated from age and blood pressure. Skin microvascular function was assessed by acetylcholine (ACh) and sodium nitroprusside (SNP) responses using iontophoresis, and expressed as the area under the curve of each vasodilator (ACh_auc and SNP_auc, respectively). Validated cognitive tasks [Addenbrooke's Cognitive Examination Revised (ACE-R), Trail Making Test Part-A (TMT-A) and Part-B (TMT-B)] were administered to assess participants' cognitive function.</p><p><strong>Results: </strong>One standard deviation (SD) increase in ePWV was positively associated with TMT-A [ β  = 0.339 (0.226, 0.467), P  < 0.001] and TMT-B [ β  = 0.342 (0.232, 0.451), P  < 0.001] after accounting for conventional cardiovascular risk factors. One SD increase in ACh_auc was also associated inversely with TMT-B after similar adjustments [ β  = -0.113 (-0.201, -0.024), P  = 0.013]. A mediation analysis revealed that the association between ePWV and TMT-B was partially mediated by ACh_auc explaining about 3% of the total effect in the crude model, but this did not persist in the adjusted model.</p><p><strong>Conclusion: </strong>Increased LAS and skin microvascular dysfunction were associated with poorer cognitive function in older adults, but LAS and skin microvascular function may independently influence cognitive function in our cohort.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1647-1654"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher skeletal muscle mass is associated with higher blood pressure and left ventricular mass.","authors":"Eduard Shantsila, Alena Shantsila, Matthew Sperrin, Zhuangzhi Gao, Yalin Zheng, Ian B Wilkinson, Paul Leeson, Iain Buchan, Gregory Y H Lip","doi":"10.1097/HJH.0000000000004375","DOIUrl":"10.1097/HJH.0000000000004375","url":null,"abstract":"<p><strong>Background and aims: </strong>Skeletal muscles make up about 40% of the body mass, but the effects of skeletal muscle mass (SMM) on blood pressure (BP) and the heart remain unclear and were explored in this study.</p><p><strong>Methods: </strong>The study used cross-sectional and longitudinal cohort designs with data from 492 498 UK Biobank (ID 54078) participants without a history of stroke [mean (SD) age 56.5 (8.1) years, 45% men, 94% white]. Muscle mass index (MMI) was measured by bioimpedance analysis, lean mass index by DEXA, and thigh MMI by MRI, fat mass index (FMI) by bioimpedance and DEXA, left ventricular mass index (LVMI) by MRI. Multivariable regression was used to relate muscle mass, BP, and LVMI.</p><p><strong>Results: </strong>On cross-sectional analysis, people with hypertension have higher values of all muscle mass metrics, which were independently associated with higher SBP and DBP after adjustment for age, sex, use of BP-lowering drugs and their interactions. Each 1 kg/m 2 higher muscle mass was associated with higher SBP by 0.67 [95% confidence interval (CI) 0.63-0.71] mmHg for MMI, 0.82 (95% CI 0.68-0.97) mmHg for lean mass index and 4.7 (95% CI 4.3-5.1) mmHg for thigh MMI. On longitudinal cohort analyses, higher values of muscle mass changes were independently associated with higher SBP and DBP after adjustment for age, sex and FMI (for SBP per 1 kg/m 2 increase) MMI during first follow-up of 4.3 years was independently associated with 2.2 (95% CI 1.9-2.5) mmHg increase in SBP, with consistent findings during longer follow-ups and MMI assessment by DEXA and MRI ( P  < 0.001 for all). Similarly, higher values of muscle mass metrics and their follow-up changes were independently associated with higher LVMI on cross-sectional and cohort analysis.</p><p><strong>Conclusion: </strong>Higher SMM is associated with higher BP and LVMI, independently of adiposity. Further research is needed to establish whether the observed association is causal and to identify the optimal exercise modes for optimal BP and better health outcomes.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1594-1604"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP.","authors":"Elpida Athanasopoulou, Thomas Weber, James E Sharman, Siegfried Wassertheurer, Mohsen Agharazii, Antonios Argyris, Sola Aoun Bahous, Jose R Banegas, Ronald K Binder, Jacques Blacher, Andréa Araujo Brandao, Kathrin Danninger, Peter Fitscha, Cristina Giannattasio, Eugenia Gkaliagkousi, Annelise Machado Gomes de Paiva, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Fotios Karachalias, Kazuomi Kario, Anastasios Kollias, Antonios Lazaridis, Yan Li, Alessandro Maloberti, Christopher C Mayer, Barry J McDonnell, Carmel M McEniery, Marco Antonio Mota-Gomes, Maria Lorenza Muiesan, János Nemcsik, Anna Paini, Sabine Perl, Gary L Pierce, Daniel Piskorz, Giacomo Pucci, Eva Reininghaus, Bernd Reininghaus, Enrique Rodilla Sala, Aletta E Schutte, Petros P Sfikakis, Alejandro de la Sierra, George S Stergiou, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Lisa J Ware, Ian B Wilkinson, Yi Zhang, Athanase D Protogerou","doi":"10.1097/HJH.0000000000004376","DOIUrl":"10.1097/HJH.0000000000004376","url":null,"abstract":"<p><strong>Background: </strong>Novel hypertension phenotypes are described by cross-classification of brachial and aortic SBP (brSBP/aoSBP).</p><p><strong>Objectives: </strong>The aim of this study is to examine their prevalence and age and sex-distribution, factors that potentially modulate them, and their association with left ventricular hypertrophy (LVH).</p><p><strong>Methods: </strong>Data on 24-h ambulatory BP monitoring (ABPM) using the Mobilograph device (IEM GmbH, Stolberg, Germany) and LVH from the I nternational 24-h A mbulatory aortic B lood pressure C onsortium (i24ABC) were retrieved from 31 centers (17 countries). The population was categorized into four phenotypes; concordant systolic normotension (CSN: both SBPs normal), isolated brachial systolic hypertension (IbrSH: high brSBP/normal aoSBP), isolated aortic systolic hypertension (IaoSH: normal brSBP/high aoSBP), and concordant systolic hypertension (CSH: both SBPs high).</p><p><strong>Results: </strong>In 8738 participants (age: 58.4 ± 15.1 years; 51.8% men), the prevalence of IaoSH was 7.7%, being more prevalent in men, and presenting a U-shape age-distribution in them compared to a linear distribution in females. IaoSH was associated with lower heart rate and beta-blockade medications. The prevalence of IbrSH was 6.5%, presenting an inverted U-shape age-distribution; it was higher in the presence of higher heart rate and calcium channel-blockade. In 2307 individuals with LVH data, after adjustment for age, sex, DBP, IaoSH - but not IbrSH - had 2.6 higher odds of LVH compared to CSN (95% confidence interval, 1.7-3.9) and similar to CSH.</p><p><strong>Conclusion: </strong>IaoSH and IbrSH amounted to almost 15% and showed specific clinic characteristics. Only IaoSH was significantly associated with LVH. Outcome-driven randomized controlled trials are needed to further investigate their clinical relevance.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1605-1616"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home blood pressure telemonitoring reveals race-specific patterns of target organ damage.","authors":"Dong-Yan Zhang, De-Wei An, Yu-Ling Yu, Błażej P Kaleta, Gontse Mokwatsi, Dries S Martens, Olugbenga O Abiodun, Tina Anya, Ruan Kruger, Godsent Isiguzo, Hui-Zhong Shi, Zhi-Kai Yang, Yu-Chen Wang, Muhammad N Shehu, Laurenço Chemo, Martin Salazar, Walter Espeche, Jana Brguljan-Hitij, Agnieszka Olszanecka, Aletta E Schutte, Agnieszka Łebek-Szatańska, Wiktoria Wojciechowska, Marek Rajzer, Andrzej Januszewicz, Katarzyna Stolarz-Skrzypek, Tim S Nawrot, Albertino Damasceno, Augustine N Odili, Jan A Staessen","doi":"10.1097/HJH.0000000000004390","DOIUrl":"10.1097/HJH.0000000000004390","url":null,"abstract":"<p><strong>Background: </strong>Racial differences in cardiac and renal target organ damage (TOD) may persist at comparable blood pressure levels. This study compared TOD in high-risk, non-African-American Black and White patients in relation to the home blood pressure (HBP).</p><p><strong>Methods: </strong>UPRIGHT-HTM (NCT04299529) is an ongoing international trial comparing risk stratification strategies in asymptomatic patients, aged 55-75  years, with ≥5 risk factors. Patients engage in HBP telemonitoring (OMRON HEM 9210-T). After 34.7 months (median), 287 Black and 154 White patients underwent echocardiography. At baseline, their chronic kidney disease (CKD) grade was assessed by cross-classification of the race-free estimated glomerular filtration rate and albuminuria (2024 KDIGO guideline). HBP was stratified by the 2024 ESC thresholds. Linear and logistic regression models, including a race-by-HBP interaction term, were applied to assess associations with the home systolic HBP.</p><p><strong>Results: </strong>The number of HBP readings was 252 215. Median systolic/diastolic HBP was 127/77 mmHg with 142 patients (32.2%) having home hypertension. Fewer Black patients received statins or combination therapy for hypertension or diabetes. Among nonhypertensive White compared to Black patients, left atrial dimensions, mitral annular s', and stroke volume had a steeper slope in relation to systolic HBP. All patients had concentric left ventricular remodeling, but only 4 Black and 13 White patients had an ejection fraction < 50%. CKD grade was worse in Black than White patients without association with HBP.</p><p><strong>Conclusions: </strong>TOD primarily affects the kidney in Black and the heart in White patients. Intensifying pharmacological treatment in sub-Saharan Africa, including antihypertensives, lipid-lowering agents, antidiabetic medications, and aspirin, should create an opportunity for improved overall cardiovascular and metabolic prevention.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1636-1646"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further perspectives on magnesium depletion and vascular health.","authors":"Sharanya Sarkar, Aayush Visaria","doi":"10.1097/HJH.0000000000004380","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004380","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1662-1663"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and hypertension management: experience the journey but fasten your seatbelt.","authors":"C Venkata S Ram","doi":"10.1097/HJH.0000000000004384","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004384","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1499-1501"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining blood pressure reduction heterogeneity in sodium-glucose cotransporter-2 inhibitor trials: a meta-analysis stratified by patient characteristics.","authors":"Josef Toma Alyas, Steffen Flindt Nielsen, Niels Henrik Buus","doi":"10.1097/HJH.0000000000004386","DOIUrl":"10.1097/HJH.0000000000004386","url":null,"abstract":"<p><p>This meta-analysis evaluated the efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in reducing blood pressure (BP), stratified by type 2 diabetes (T2DM) and end-organ damage status. A PRISMA-compliant systematic review identified 38 RCTs ( n  = 48 828). In patients with T2DM, SBP decreased by -3.66 mmHg (95% CI: -4.16, -3.16) and DBP by -1.33 mmHg (95% CI: -1.68, -0.98). Populations without T2DM showed a significant SBP reduction of -1.79 mmHg (95% CI: -2.85, -0.72), but a nonsignificant DBP reduction. Significant antihypertensive effects were observed regardless of end-organ damage status. However, the conservative Robust Bayesian Meta-analysis ('RoBMA') attenuated most results to clinically trivial reductions (<2 mmHg), except in T2DM populations. Meta-regression identified T2DM and 24-h BP measurement as significant moderators for greater SBP reduction. However, baseline BP and end-organ damage were not moderators. These findings indicate the BP-lowering efficacy of SGLT-2i is most pronounced in patients with T2DM and when assessed via 24 h BP measurements.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1487-1498"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}