Journal of Hypertension最新文献

{"title":"The European Society of Cardiology got it wrong: their target systolic blood pressure in chronic kidney disease patients is not low enough!","authors":"Robert S Brown","doi":"10.1097/HJH.0000000000004048","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004048","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 7","pages":"1263-1265"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of telemonitoring and home blood pressure monitoring on blood pressure reduction in hypertensive adults: a network meta-analysis.","authors":"Shubhima Grover, Hara Prasad Mishra, Rachna Gupta, Lalit K Gupta","doi":"10.1097/HJH.0000000000004008","DOIUrl":"10.1097/HJH.0000000000004008","url":null,"abstract":"<p><strong>Introduction: </strong>Telemonitoring and home blood pressure monitoring (HBPM) are becoming popular approaches for managing hypertension. They are believed to improve patient compliance as compared to the usual care monitoring. This network meta-analysis was undertaken to compare blood pressure (BP) reduction following telemonitoring, HBPM and usual care BP monitoring approaches.</p><p><strong>Methods: </strong>PubMed and clinicaltrial.gov were searched till 15 May 2024 for randomized controlled trials (RCTs) comparing telemonitoring, HBPM and usual care monitoring for reduction in BP and the postintervention BP in hypertensive adults.</p><p><strong>Results: </strong>A network meta-analysis with 24 RCTs was performed using MetaInsight. Telemonitoring produced a significantly greater reduction in the systolic blood pressure (SBP) (-3.69 mmHg [95% CI -5.82; -1.57, P  < 0.001]) and the diastolic blood pressure (DBP) (-1.82 mmHg [95% CI -2.98 to -0.67, P  < 0.001]) as compared to the usual care monitoring. Home BP monitoring also produced a greater lowering of SBP (-2.73 mmHg [95% CI -5.69 to 0.22, P  = 0.069]) and DBP (-2.09 mm Hg [95% CI -3.66 to -0.52, P  < 0.001]) than usual care, with a significant reduction in the DBP alone. The postintervention SBP and DBP were also lower in the telemonitoring and the HBPM groups than the usual care group. However, there was no significant difference between the SBP and the DBP reductions in the telemonitoring and the HBPM groups.</p><p><strong>Conclusion: </strong>Telemonitoring and HBPM may be more useful in controlling BP as compared to usual care management alone. However, more direct studies comparing telemonitoring with HBPM are needed in the future.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1091-1098"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the relationship between short-term blood pressure variability and glycation profile in young and middle-aged nondiabetic hypertensive individuals.","authors":"Nestor Vazquez-Agra, Lucia Barrera-Lopez, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras","doi":"10.1097/HJH.0000000000004029","DOIUrl":"10.1097/HJH.0000000000004029","url":null,"abstract":"<p><strong>Introduction: </strong>Elevated short-term blood pressure (BP) variability (BPV) has been associated with a poorer cardiovascular prognosis. The glycation profile is related to BPV in diabetic and prediabetic individuals. However, little is known about the relationship between glycation levels and BPV in hypertensive patients with optimal glycemic control.</p><p><strong>Objectives: </strong>This observational study aimed to elucidate the relationship between glycated hemoglobin (HbA1c) levels and short-term BPV in young and middle-aged hypertensive patients over 18 years with HbA1c levels below 5.7%.</p><p><strong>Methods: </strong>We collected and analyzed data on 24-h ambulatory BP monitoring, demographic, epidemiological, clinical, and laboratory variables from 143 hypertensive patients. BPV was measured as the standard deviation (SD) and average real variability (ARV) in millimeters of mercury, as well as the dimensionless coefficient of variation (CV).</p><p><strong>Results: </strong>Depending on the index, each one unit increase in nighttime SD and CV indices was associated with a 17-24% higher likelihood of elevated HbA1c levels (higher than 5.2%). Regarding BPV dipping, each 1% decrease in nighttime SD and CV dipping was associated with a 10-20% higher risk of increased HbA1c levels. Additionally, each 1% decrease in nighttime ARV DBP dipping was also associated with a 10% higher risk of elevated HbA1c levels. A one-standardized-unit increase in the overall combined BPV index, as a pooled measure of BPV, was associated with a 45% higher likelihood of raised HbA1c levels.</p><p><strong>Conclusion: </strong>Even within the optimal range, elevated HbA1c levels may reflect an underlying increase in BPV, which may be particularly relevant given the prognostic implications of short-term BPV.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1148-1157"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension determinants among Ghanaians differ according to location of residence: RODAM study: Erratum.","authors":"","doi":"10.1097/HJH.0000000000004033","DOIUrl":"10.1097/HJH.0000000000004033","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 7","pages":"1266"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DDX17 deficiency inhibits the proliferation and migration of vascular smooth muscle cells by inhibiting RHEB/mTORC1-mediated glycolysis and oxidative stress.","authors":"Ying Li, Chenming Qiu, Xi Wu, Sheng Hu","doi":"10.1097/HJH.0000000000004043","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004043","url":null,"abstract":"<p><p>As an RNA-binding protein, DEAD-box RNA helicase 17 (DDX17) plays a critical role in influencing gene expression and participates in the proliferation and migration of several cell lines. The current study aims to investigate the role of DDX17 in vascular smooth muscle cell (VSMC) proliferation and migration and vascular intimal hyperplasia. DDX17 expression was upregulated in injured mouse arteries and platelet derived growth factor (PDGF)-BB-treated VSMCs. An adeno-associated virus serotype 9 vector carrying Ddx17 short hairpin RNA (shDdx17) was used to silence DDX17 expression in vivo. DDX17 silencing significantly ameliorated injury-induced mouse vascular intimal hyperplasia. In vitro, the recombinant lentivirus carrying Ddx17 shRNA (Len-Ddx17i) was used to inhibition DDX17 expression in VSMCs. DDX17 deficiency inhibited PDGF-BB-induced phenotypic switching of VSMCs. Bioinformatics analysis revealed that DDX17 expression is closely related to glucose metabolism- and oxidative stress-associated pathways. Next, we found that glycolysis and oxidative stress were both attenuated by DDX17 ablation in VSMCs. Mechanically, reduced ras homolog enriched in brain (RHEB) expression and decreased mammalian target of rapamycin complex 1 (mTORC1) activity were observed after silencing of DDX17 in PDGF-BB-challenged VSMCs. Upregulating RHEB expression or elevating mTORC1 activity abolished the inhibitory effects of DDX17 silencing on PDGF-BB-induced glycolysis, oxidative stress, proliferation, and migration in VSMCs. Furthermore, the decreased mTORC1 activity induced by DDX17 deficiency was also reversed by RHEB overexpression. In conclusion, DDX17 silencing attenuates VSMC proliferation and migration by inhibiting RHEB/mTORC1-mediated glycolysis and oxidative stress, thus suppressing vascular intimal hyperplasia.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 7","pages":"1232-1246"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Within-visit blood pressure variability in children and adolescents in the National Health and Nutrition Examination Survey (2013-2020).","authors":"Sandeep K Riar, Scott Gillespie, Andrew M South","doi":"10.1097/HJH.0000000000004006","DOIUrl":"10.1097/HJH.0000000000004006","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) varies depending on several factors. The objective of our study was to describe within-visit BP variability (BPV) in healthy children and compare BPV between manual and automated BP readings.</p><p><strong>Methods: </strong>We included individuals aged 8-17 years with three BP readings from NHANES 2013-2020 cycles. From 2013 to 2016, BP was obtained using auscultation (manual protocol, MP) and, subsequently, using oscillometry (automated protocol, AP). We excluded individuals with DBP 'zero'.</p><p><strong>Results: </strong>In 5656 individuals [MP group: 3365 (59.5%); AP group: 2291 (40.5%]), a ΔBP (difference between highest and lowest of three BP readings) at least 5 mmHg was noted in 49.1 and 60.7% of individuals for SBP and DBP, respectively. ΔDBP at least 10 mmHg was twice as common in the MP group as in the AP group. ΔDBP at least 20 mmHg was observed in 4.4% individuals. A difference of at least 5 mmHg between the initial and averaged second and third BP readings was noted in 24.9 and 34.5% of individuals for SBP and DBP, respectively. The highest of three BP readings was the first, second, or third in 44.2, 30.5, and 25.4% of individuals, for SBP, and 42.4, 29.8, and 27.7%, for DBP respectively.</p><p><strong>Conclusion: </strong>Less than half of individuals had three DBP readings within 5 mmHg and some had ΔBP at least 20 mmHg. Initial BP is not always the highest; inclusion of the second and third BP readings may be more representative of the individual's actual BP. DBPV was higher with manual than with automated BP measurement.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1158-1168"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension accelerates the development of a diabetic nephropathy model with more relevant clinical features in Dahl salt-sensitive rat.","authors":"Lijun Hu, Jing Li, Weizhi Wang, Yong Li, Baohua Gu, Yao Tian, Qiyan Ruan, Juncheng Deng","doi":"10.1097/HJH.0000000000004038","DOIUrl":"10.1097/HJH.0000000000004038","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic nephropathy is becoming an increasing health problem and the major cause of chronic kidney disease. The lack of experimental models that reproduce all structural and functional alterations of human diabetic nephropathy is one of the barriers to solve these clinical needs in basic research. We aimed to establish a simple and rapid method for diabetic nephropathy induction in Dahl salt-sensitive rats and achieved more clinical relevant features.</p><p><strong>Methods and results: </strong>Six or seven-week-old male Dahl salt-sensitive rats were used to induce diabetes by a single injection of streptozotocin (STZ; 45 mg/kg, intraperitoneally). After 7 days, rats with diabetes (will refer as STZ-DS rats) will be used for further studies. STZ-DS rats will be grouped and were fed with water or water containing 0.3%/0.9%/2% NaCl and a regular chow throughout the study. We found that STZ-treated Dahl salt-sensitive rat fed with 0.9% NaCl in drinking water (STZ-DS + 0.9% NaCl) displayed most of the characteristics of human diabetic nephropathy and the model meets the criteria of the diabetic nephropathy standards proposed by Animal Models of Diabetic Complications Consortium (AMDCC); which includes a 10-fold increase in albuminuria, more than 50% decline in estimated glomerular filtration rate over the lifetime, hypertrophy, thickening of the glomerular basement membrane, expansion of the mesangial matrix, any degree of arteriolar hyalinosis, severe glomerulosclerosis, and tubulointerstitial fibrosis.</p><p><strong>Conclusion: </strong>STZ-DS + 0.9% NaCl is an improved diabetes nephropathy model and more suited for the study of the signaling pathways and mechanisms in the progression of diabetes-induced renal disease. The model will facilitate the development of new therapies for diabetes nephropathy.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1225-1231"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic esaxerenone treatment improves vascular function and lowers peripheral arterial stiffness in patients with idiopathic hyperaldosteronism.","authors":"Shinji Kishimoto, Tatsuya Maruhashi, Masato Kajikawa, Aya Mizobuchi, Takahiro Harada, Takayuki Yamaji, Yukiko Nakano, Chikara Goto, Farina Mohamad Yusoff, Yukihito Higashi","doi":"10.1097/HJH.0000000000004030","DOIUrl":"10.1097/HJH.0000000000004030","url":null,"abstract":"<p><strong>Objective: </strong>Primary aldosteronism is one of the most common types of secondary endocrine hypertension. Treatment with mineralocorticoid receptor antagonists is recommended for bilateral idiopathic hyperaldosteronism (IHA). The purpose of this study was to evaluate the effects of esaxerenone, a nonsteroidal mineralocorticoid receptor antagonist with high mineralocorticoid receptor-binding specificity, on vascular function and peripheral arterial stiffness in patients with IHA.</p><p><strong>Methods: </strong>This study was a single-center, observational prospective cohort study. Forty-four patients with IHA (18 men and 26 women; 52 ± 11 years) were enrolled from Hiroshima University Hospital. Vascular function, including flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) and peripheral arterial stiffness, including brachial-ankle pulse wave velocity (baPWV) and brachial artery intima-media thickness (bIMT) were measured before and after 12 weeks of treatment with esaxerenone.</p><p><strong>Results: </strong>Esaxerenone treatment increased FMD (3.1 ± 2.0% to 5.7 ± 2.2%, P  < 0.01) and NID (10.7 ± 3.8% to 15.7 ± 6.2%, P  < 0.01) and decreased baPWV (1605 ± 263 to 1428 ± 241 cm/s, P  < 0.01), while esaxerenone treatment did not significantly alter bIMT. The changes in FMD and NID posttreatment with esaxerenone were significantly correlated with the changes in plasma aldosterone concentration (PAC) and plasma renin activity (PRA). The change in baPWV was significantly correlated with the changes in PRA, aldosterone-to-renin ratio, and systolic blood pressure.</p><p><strong>Conclusion: </strong>Esaxerenone improved vascular function and peripheral arterial stiffness in patients with IHA. These findings suggest aldosterone inhibition is a potential mechanism governing improvement in cardiovascular health.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1205-1213"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular events and biochemically negative paragangliomas: a systematic review.","authors":"George Tsorbatzoglou, Foteini Thanasoula, Chrysoula Mytareli, Elisavet Tasouli, Alexandros Smyrnis, Konstantinos Kontzoglou, Gregory Kaltsas, Anna Angelousi","doi":"10.1097/HJH.0000000000004026","DOIUrl":"10.1097/HJH.0000000000004026","url":null,"abstract":"<p><strong>Objective: </strong>To study cardiovascular morbidity in patients with biochemically inactive pheochromocytomas/paragangliomas.</p><p><strong>Methods: </strong>PubMed, Cochrane, and Scopus databases were searched by two independent reviewers to identify relevant studies. Twenty-four case reports ( n  = 24 patients) met the inclusion criteria providing data on the cardiovascular status of biochemically negative pheochromocytomas/paragangliomas patients. Methodological quality was assessed by the Grading of Recommendations, Assessment, Development and Evaluations system, and all included studies were assessed for the risk of bias. This systematic review was conducted in conformance with the PRISMA statement and registered to PROSPERO (ID: CRD42024530601).</p><p><strong>Results: </strong>Almost half of patients (46%) presented objective abnormal findings on noninvasive cardiovascular examination performed routinely before surgery, whereas 67% complained of pheochromocytoma/paraganglioma-related symptoms (angina, headache, diaphoresis, shortness of breath, palpitations) and exhibited relevant clinical signs (hypertension, tachycardia, tachypnea, pallor). Preoperatively, only 38% of patients with biochemically negative pheochromocytomas/paragangliomas were treated with alpha-blockers, 25% did not receive any pharmaceutical preparation whereas data were not available for the remaining 37% of patients. Following an uneventful surgery, 70% of patients exhibited resolution of the preoperatively detected cardiovascular symptoms and signs.</p><p><strong>Conclusion: </strong>The high occurrence of cardiovascular abnormalities in patients with pheochromocytomas/paragangliomas characterized as \"biochemically negative\" based on routine biochemical analyses highlights the difficulty in the appropriate classification of these tumors regarding their secretory profile and thus the risk of missing cardiovascular system involvement with potentially deleterious effects.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1116-1125"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission blood pressure and blood pressure variability in medical emergency predicts 3-month mortality and readmission.","authors":"Emma Hildur Jensen Malm, Anton W Petersen, Rakin Hadad, Steen B Haugaard, Michael H Olsen, Philip L Bonde, Helena Dominguez, Edina Hadziselimovic, Ahmad Sajadieh","doi":"10.1097/HJH.0000000000004027","DOIUrl":"10.1097/HJH.0000000000004027","url":null,"abstract":"<p><strong>Background: </strong>The admission systolic blood pressure (SBP) recorded at the emergency department is typically elevated and tends to decrease, while various degrees of blood pressure variability (BPV) remain. Whether admission SBP or mean SBP and BPV from resting beat-to-beat measurements are better associated with short-term outcome remains unknown.</p><p><strong>Methods: </strong>We conducted a prospective study, including adults acutely admitted to the emergency department at a larger Danish tertiary care Hospital in Copenhagen, Denmark from 2019 to 2023. We measured blood pressure (BP) at admission and beat-to-beat BP and BPV during 10-minute rest. We defined BPV as the standard deviation from the mean of the beat-to-beat SBP measurements. Primary outcome was defined as 3-month all-cause mortality or readmission, and secondary outcome as 3-month cardiovascular mortality or readmission for cardiovascular disease.</p><p><strong>Results: </strong>Among 951 patients included, mean age was 64 (standard deviation; 17) with 44% women. During 3-month follow-up, 284 (30%) patients met a primary outcome and 69 (7,2%) a secondary outcome. In adjusted Cox models, admission SBP, but neither mean SBP or BPV, was significantly associated with primary outcome [hazard ratio 0.971, 95% confidence interval (CI) 0.948-0.995, P  = 0.017] for each 5 mmHg increase in SBP. When exploring both extremes of upper and lower quartiles, BPV greater than 10 mmHg was associated with increased cardiovascular events (hazard ratio 2.019, 95% CI 1.142-3.569, P  = 0.016).</p><p><strong>Conclusion: </strong>In this study, low admission SBP was associated with all-cause readmissions and mortality, while BPV above 10 mmHg was associated with 3-month risk of cardiovascular events.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1198-1204"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}