Journal of Hypertension最新文献

{"title":"Effectiveness of a hybrid model education program for hypertension management: a secondary analysis of healthy community clinic records in Jordan.","authors":"Khitam Alsaqer, Sara Abu Hashish, Mariam Kawafha, Duaa Al-Maghaireh, Abdullah Al Nsour, Rami Farraj, Amal Ireifij, Saif Fakhoury, Mohammad Ayyad, Saba Abu Fanouneh","doi":"10.1097/HJH.0000000000004361","DOIUrl":"10.1097/HJH.0000000000004361","url":null,"abstract":"<p><strong>Background: </strong>Uncontrolled hypertension contributes substantially to the burden of noncommunicable diseases and poses a significant threat to public health. Despite the high prevalence of hypertension in Jordan, gaps remain in effective management strategies and community awareness.</p><p><strong>Objective: </strong>To evaluate the effectiveness of the Hybrid Model Education Program implemented in Healthy Community Clinics (HCCs) in Jordan.</p><p><strong>Methods: </strong>This study was designed as a prospective longitudinal secondary analysis of the HCCs' database. Data were collected from April 2024 through December 2024. Of the 17 519 adult beneficiaries who attended HCCs across Jordan, 9193 adults with a documented diagnosis of hypertension and complete clinical data were analyzed. Descriptive statistics and repeated measures analyses were performed to assess changes across five educational sessions in blood pressure, weight, dietary habits, and physical activity.</p><p><strong>Results: </strong>The analytic sample included 9193 hypertensive adults (mean age 55.6 years; 63.9% female). Most participants resided in the Middle region (63.8%), and 25.5% were current smokers. Across sessions, statistically significant improvements were observed in mean weight (-3.0 kg, 95% CI: -3.9 to -2.1), systolic BP (-8.1 mmHg, 95% CI: -9.5 to -6.7), diastolic BP (-3.0 mmHg, 95% CI: -3.8 to -2.2), vegetable meal consumption (+0.39 meals/day, 95% CI: +0.31 to +0.47), and proportion classified as physically active (+9.8%, P  < 0.001).</p><p><strong>Conclusion: </strong>This study, based on a census of available HCCs' records, provides evidence that the Hybrid Model Education Program can effectively improve lifestyle behaviors and hypertension control in a large community-based Jordanian population.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1510-1517"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term prognostic impact of a novel arterial stiffness index using upper-arm cuff oscillometric inflation.","authors":"Noriyuki Kawaura, Rie Nakashima-Sasaki, Kotaro Uchida, Takuya Sugawara, Sae Saigo, Shintaro Minegishi, Kaito Abe, Lin Chen, Kouji Yamamoto, Kiyoshi Hibi, Tomoaki Ishigami","doi":"10.1097/HJH.0000000000004359","DOIUrl":"10.1097/HJH.0000000000004359","url":null,"abstract":"<p><strong>Background: </strong>Arteriosclerosis is a leading cause of cardiovascular events and effective predictive tools are required for its prevention. The AVE-1500 device noninvasively measures the arterial pressure volume index (API) and arterial velocity pulse index (AVI), which reflect arterial stiffness and central pressure, using upper-arm cuff oscillometric inflation. This study aimed to investigate the long-term prognosis of these novel noninvasive vascular indices, API and AVI, in outpatients with diverse clinical backgrounds.</p><p><strong>Methods results: </strong>In this retrospective, single-center, observational cohort study, 230 outpatients with diverse clinical profiles were monitored over an average follow-up period of 2473 days. Of the patients, 61.8% were men, and the overall mean age was 68.5 ± 12.1 years. The mean API and AVI were 32.5 and 23.9, respectively. Patients were stratified based on API (≤ 32.0 vs. > 32.0) and AVI (≤ 27.0 vs. > 27.0). Kaplan-Meier survival analysis showed significant differences in all-cause mortality, cardiovascular events, and the composite endpoint between the groups ( P  < 0.05).</p><p><strong>Conclusion: </strong>This study found that API and AVI have long-term prognostic value in patients at risk of arteriosclerosis.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1502-1509"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of treatment response to mineralocorticoid receptor antagonists in primary aldosteronism: insights from the SPAIN-ALDO registry.","authors":"Jessica Goi, Miguel Paja Fano, Alicia Rizo Gellida, Marga González-Boillos, Patricia Martín Rojas-Marcos, Laura Caja Guayerbas, Ana María García Cano, Jorge Gabriel Ruiz-Sanchez, Emilia Gómez-Hoyos, Mònica Recasens, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina María Perdomo, Laura Manjón-Miguélez, Ángel Rebollo Román, Cristina Robles Lázaro, José María Recio, María Calatayud, Noemi Jiménez López, Miguel Sampedro Nuñez, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, Joaquín Serrano, Theodora Michalopoulou, Susana Tenes Rodrigo, Eider Pascual-Corrales, Fernando Jaén Aguila, Nuria Muñoz Rivas, Eva María Moya Mateo, Sonsoles Gutiérrez-Medina, Felicia Alexandra Hanzu, Paola Parra Ramírez, Marta Araujo-Castro","doi":"10.1097/HJH.0000000000004365","DOIUrl":"10.1097/HJH.0000000000004365","url":null,"abstract":"<p><strong>Background: </strong>Data on factors predicting favorable response to medical therapy in primary aldosteronism, based on Primary Aldosteronism Medical treatment Outcome (PAMO) criteria, remain limited.</p><p><strong>Aim: </strong>This study aimed to identify baseline parameters independently associated with clinical and biochemical responses to mineralocorticoid receptor antagonist (MRA) therapy after at least 6  months of treatment.</p><p><strong>Methods: </strong>Primary aldosteronism patients from the SPAIN-ALDO registry, treated medically with MRA (or amiloride) and with available clinical and/or biochemical follow-up data after at least 6 months of therapy were included.</p><p><strong>Results: </strong>A total of 402 patients (38.3% women; mean age 57 ± 11.8 years) were analyzed. Median follow-up duration was 38  months [interquartile range (IQR) 20-76]. At last visit, 55% of patients were receiving spironolactone, 44% eplerenone, and 1.2% amiloride. Among 389 patients with clinical follow-up data, 16.2% achieved complete clinical success, 65.5% partial response, and 18.3% showed no response. Complete clinical response was more likely in women, in patients with lower BMI, fewer antihypertensive medications, and higher potassium levels. Among 261 patients with biochemical follow-up data, 50.1% had complete biochemical response, 21.5% partial, and 28.4% absent. Predictors of complete biochemical response included lower baseline aldosterone concentration, higher baseline renin levels, use of spironolactone rather than eplerenone, and higher MRA doses.</p><p><strong>Conclusion: </strong>Early identification of primary aldosteronism and optimized titration of MRA therapy, especially with eplerenone, are crucial for improving clinical and biochemical outcomes.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1530-1538"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium depletion score is associated with arterial stiffness: data from the Brisighella Heart study: A critical appraisal.","authors":"Iqra Akhtar, Muhammad Hassaan Javaid","doi":"10.1097/HJH.0000000000004352","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004352","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1655-1656"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Methodological and interpretive concerns regarding 'asymmetric U-shaped association between first trimester maternal free thyroxine levels and the risk of preeclampsia'.","authors":"Sha Chen, Xueya Zhao, Lina Xia, Yu Meng","doi":"10.1097/HJH.0000000000004387","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004387","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1658-1659"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological inconsistencies and nomenclature errors in 'Arterial hypertension-attributable mortality in Europe', 2012-2021.","authors":"Aurelio Cayuela, Lucía Cayuela","doi":"10.1097/HJH.0000000000004379","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004379","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1659-1660"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium depletion score is associated with arterial stiffness: a critical appraisal.","authors":"Arrigo F G Cicero, Federica Fogacci","doi":"10.1097/HJH.0000000000004364","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004364","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1656-1657"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Astragalus membranaceus on inflammation and apoptosis in rats with preeclampisa.","authors":"Xu Zhang, Guohua Zhang, Yinmin Chen, Lijun Yang, Huiniu Hao, Jiaxin Meng, Ruifan Gao, Hailan Yang, Zengrong Tu","doi":"10.1097/HJH.0000000000004360","DOIUrl":"10.1097/HJH.0000000000004360","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia, an idiopathic multifactorial hypertensive disorder associated with pregnancy, is characterized by systemic immune regularization, inflammatory, excessive placental apoptosis, and widespread vasoconstriction, among other pathological features. Astragalus membranaceus (AMS) exhibits diverse biological activities, including immunomodulation, antiapoptosis, antioxidation, antiinflammatory and anticancer effects. Numerous studies have demonstrated its therapeutic potential in mitigating endothelial injury, reducing blood pressure, and improving renal function. In this systematic in-vivo investigation, we elucidated the biological activity and mechanistic underpinnings of AMS in ameliorating preeclampsia development.</p><p><strong>Methods: </strong>The optimal dosage of AMS was determined through preliminary experiments. Pregnant Sprague-Dawley rats ( n  = 40) were randomly allocated into four experimental groups: control, control+AMS, L -NAME-treated, and L -NAME + AMS-treated. Inflammatory and placental apoptosis-related markers were analyzed using real-time quantitative PCR (RT-qPCR), Western blotting, and immunohistochemistry. Additionally, ELISA was conducted to quantify the expression of inflammation-related genes.</p><p><strong>Results: </strong>AMS significantly ameliorated hypertension, proteinuria, and abortion rates of rats with preeclampsia with l -NAME-induced. It effectively inhibited the placental and serum expression of TNF-α at both mRNA and protein levels, while simultaneously increasing placental and serum levels of IL-10 and mitigating serum IL-6 expression, mitigating inflammation in rats with preeclampisa. Furthermore, AMS reduced FAS in the extrinsic apoptosis pathway and regulated BCL-2/BAX/BAK/AIF in the mitochondrial apoptosis pathway in rats with preeclampsia.</p><p><strong>Conclusion: </strong>Our study demonstrates that AMS significantly reduced the hypertension and proteinuria in rats with preeclampsia. AMS alleviates inflammation and apoptosis in rats with preeclampsia by regulating inflammatory factors and mitochondrial outer membrane permeability (MOMP). Additional AMS reduced FAS (CD95/APO-1), in the extrinsic apoptosis pathway. AMS offers a potential therapeutic strategy for preeclampsia.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1518-1529"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological and interpretive concerns regarding \"Asymmetric U-shaped association between first trimester maternal free thyroxine levels and the risk of preeclampsia\".","authors":"Muhammad Adil, Zia Ullah, Zain Ul Abedeen, Abdul Basit, Fareed Ullah, Aiman Khaliq, Saman Naz","doi":"10.1097/HJH.0000000000004372","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004372","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 9","pages":"1657-1658"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of simplified ambulatory nocturnal blood pressure monitoring for nocturnal hypertension and target organ damage assessment.","authors":"Qing Liu, Yukun Liang, Yancui Sun, Minghui Gong, Minghui Yang, Ying Zhang, Yinong Jiang, Wei Song","doi":"10.1097/HJH.0000000000004378","DOIUrl":"10.1097/HJH.0000000000004378","url":null,"abstract":"<p><strong>Objective: </strong>Nocturnal blood pressure (BP) is a more sensitive predictor of cardiovascular risk. However, frequent nighttime measurements may disrupt sleep and reduce patient compliance. Therefore, this study aimed to investigate whether simplified nocturnal or awake BP readings could effectively diagnose nocturnal hypertension (NHT) and assess associated target organ damage (TOD).</p><p><strong>Methods: </strong>Two thousand four hundred seventy-five hypertensive patients with complete 24-h ambulatory BP monitoring (ABPM) data between January 2021 and December 2023 were recruited in this retrospective study. Six SBP indicators, including fixed-interval SBP, extended-interval SBP, evening SBP, morning SBP, daytime SBP, and morning-evening average SBP, were adopted to explore the agreement with mean nocturnal SBP and diagnostic potential for NHT, as well as their relationship with TOD.</p><p><strong>Results: </strong>Among different SBPs, fixed-interval SBP (measured at 02 : 00, 03 : 00, and 04 : 00) showed the strongest correlation with nocturnal SBP ( r  = 0.961, P  < 0.001). Bland-Altman analysis indicated good agreement, with a mean bias of 0.81 mmHg (95% confidence interval: 0.61-1.01) and 95.1% of data points falling within the limits of agreement, further supported by an intraclass correlation coefficient of 0.960. Compared to other five SBPs, fixed-interval SBP demonstrated the best diagnostic performance for NHT (area under the curve = 0.974, P  < 0.001) with the optimal cut-off 120.5 mmHg. Logistic analysis confirmed that fixed-interval SBP remained independently associated with TOD risk after multivariable adjustment.</p><p><strong>Conclusion: </strong>Our analysis suggests that a simplified 3-time-point nocturnal SBP protocol might be considered as a potential alternative to conventional ABPM for diagnosing NHT and evaluating TOD.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1617-1625"},"PeriodicalIF":5.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}