Journal of Hypertension最新文献_第7页

Sleep blood pressure and cardiovascular events in men and women. 男性和女性的睡眠血压和心血管事件。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-02-01 Epub Date: 2025-01-02 DOI: 10.1097/HJH.0000000000003913

Yasuharu Tabara

引用次数: 0

A rheumatological perspective on hypertension: a role for disease-modifying antirheumatic drugs? 高血压的风湿病学观点：改善疾病的抗风湿药物的作用？

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-02-01 Epub Date: 2025-01-02 DOI: 10.1097/HJH.0000000000003876

Stephen Poos, Noha Hassan, Shan Jin, Ikhtesham Chuadhry, David F Lo

引用次数: 0

Advancements in cardiovascular risk assessment: the prognostic value of arterial stiffness metrics. 心血管风险评估的进展：动脉硬度指标的预后价值。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-02-01 Epub Date: 2025-01-02 DOI: 10.1097/HJH.0000000000003896

Muhammad Osama, Safiyyah Ubaid, Ubaid Ullah, Maryam Ubaid

引用次数: 0

Beyond awareness: time to tackle nonadherence with precision. 超越意识：是时候精确地解决不遵守规定的问题了。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-02-01 Epub Date: 2025-01-02 DOI: 10.1097/HJH.0000000000003933

Prashanth Patel, Pankaj Gupta

引用次数: 0

Prospective associations of genetic susceptibility to high blood pressure and muscle strength with incident cardiovascular disease outcomes. 高血压遗传易感性和肌肉力量与心血管疾病发病结果的前瞻性关联。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-02-01 Epub Date: 2024-10-14 DOI: 10.1097/HJH.0000000000003900

Mengyao Wang, Paul James Collings, Haeyoon Jang, Ziyuan Chen, Shan Luo, Shiu Lun Au Yeung, Stephen J Sharp, Soren Brage, Youngwon Kim

{"title":"Prospective associations of genetic susceptibility to high blood pressure and muscle strength with incident cardiovascular disease outcomes.","authors":"Mengyao Wang, Paul James Collings, Haeyoon Jang, Ziyuan Chen, Shan Luo, Shiu Lun Au Yeung, Stephen J Sharp, Soren Brage, Youngwon Kim","doi":"10.1097/HJH.0000000000003900","DOIUrl":"10.1097/HJH.0000000000003900","url":null,"abstract":"Background: This study explored the prospective associations of genetic susceptibility to high blood pressure (BP) and muscle strength with cardiovascular disease (CVD) mortality, incident coronary heart disease (CHD) and incident stroke.Methods: This study included 349 085 white British individuals from the UK Biobank study. Genetic risk of high BP was estimated using a weighted polygenic risk score that incorporated 136 and 135 nonoverlapping single-nucleotide polymorphisms for systolic BP and diastolic BP, respectively. Muscle strength was assessed using a hand dynamometer and expressed relative to fat-free mass. Sex- and age-specific tertiles were used to classify muscle strength into three categories. Cox regressions with age as the underlying timescale were fit for CVD mortality ( n = 8275), incident CHD ( n = 14 503), and stroke ( n = 7518).Results: Compared with the lowest genetic risk of high BP (bottom 20%), the highest (top 20%) had greater hazards of each outcome. Low muscle strength was associated with higher hazards of CVD mortality [hazard ratio (HR): 1.51, 95% confidence interval (CI): 1.43-1.59], incident CHD (HR: 1.16, 95% CI: 1.11-1.21), and stroke (HR: 1.20, 95% CI: 1.14-1.27), independently of confounders and genetic predisposition to high BP, compared with high muscle strength. Joint analyses revealed that the estimated 10-year absolute risks of each outcome were lower for high muscle strength combined with high genetic risk, compared with low muscle strength combined with low or medium genetic risk.Conclusion: Individuals who are genetically predisposed to high BP but have high muscle strength could have lower risk of major CVD events, compared with those who have low or medium genetic risk but low muscle strength.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"280-289"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of sacubitril-valsartan in hypertension patients with end-stage kidney disease on maintenance dialysis: a meta-analysis.

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-01-30 DOI: 10.1097/HJH.0000000000003972

Dung Viet Nguyen, Giang Thai Pham, Son Nguyen Pham, Hoai Thi Thu Nguyen

{"title":"Efficacy and safety of sacubitril-valsartan in hypertension patients with end-stage kidney disease on maintenance dialysis: a meta-analysis.","authors":"Dung Viet Nguyen, Giang Thai Pham, Son Nguyen Pham, Hoai Thi Thu Nguyen","doi":"10.1097/HJH.0000000000003972","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003972","url":null,"abstract":"The aim of this meta-analysis was to assess the efficacy and safety of sacubitril-valsartan in hypertension patients with end-stage kidney disease (ESKD) undergoing dialysis. We searched the Medline, Cochrane, Embase, Web of Science, and ClinicalTrials.gov databases for studies reporting outcomes after SV treatment. All analyses were performed utilizing the random effects models. Nineteen studies comprising 1597 patients with concomitant hypertension and ESKD undergoing dialysis were included. After sacubitril-valsartan treatment, significant reductions in both SBP and DBP were observed (mean change in SBP: -11.09 mmHg [95% confidence interval, 95% CI: -14.51,-7.66] and DBP: -4.37 mmHg [-6.36,-2.38]). Compared to conventional treatment, patients treated with sacubitril-valsartan had a lower risk of cardiovascular hospitalization (risk ratio: 0.63 [0.44,0.90]). Sacubitril-valsartan treatment showed a trend toward reducing the risk of all-cause mortality, although this was not statistically significant (risk ratio: 0.66 [0.27,1.60]). Evaluation of echocardiographic parameters among studies including hypertension patients with heart failure indicated that SV improved LVEF (mean change: +7.04%[+3.19, +10.90]), however this effect was more pronounced in the HFrEF patients (Pinteraction=0.0003). Sacubitril-valsartan also reduced LVSd, LVDd, LAD, and E/e' ratio (P < 0.05). The risks of severe hyperkalemia and symptomatic hypotension were comparable between sacubitril-valsartan treatment and conventional treatment (P > 0.05). The present study revealed that sacubitril-valsartan treatment is well tolerated and could have potential benefits in hypertension patients with ESKD on dialysis by effectively controlling blood pressure, improving LVEF, reversing cardiac remodeling, and reducing the risk of cardiovascular hospitalization.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective relationships between left ventricular mass, brachial and central blood pressures in participants from the UK Biobank.

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-01-24 DOI: 10.1097/HJH.0000000000003969

James E Sharman, Fumihiko Takeuchi, Athanase Protogerou, Thomas Weber, Siegfried Wassertheurer, Thomas H Marwick

{"title":"Prospective relationships between left ventricular mass, brachial and central blood pressures in participants from the UK Biobank.","authors":"James E Sharman, Fumihiko Takeuchi, Athanase Protogerou, Thomas Weber, Siegfried Wassertheurer, Thomas H Marwick","doi":"10.1097/HJH.0000000000003969","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003969","url":null,"abstract":"Background: Central SBP purports to aid hypertension management. This concept is founded on cross-sectional studies; however, findings are mixed and few report longitudinal relationships between changes in blood pressure (BP) and outcomes. This study aimed to determine associations of changes in brachial BP and central BP with changes in left ventricular mass index (LVMi), as an important hypertension-related clinical outcome.Methods: Standard brachial BP and central BP (Vicorder, Skidmore Medical, UK; a type 1 device, using SBP/DBP calibration) were measured at the same time as cardiac MRI for LVMi among adults from the UK Biobank Cohort Study assessed prospectively at two time points (2014+ and 2019+). Analysis was by linear regression adjusted for demographic and clinical characteristics.Results: Data were evaluable for 681 participants (aged 50.1 ± 7.1 years, 54% women) followed over 3.2 ± 1.6 years [mean ± standard deviation (SD)]. Cross-sectional analysis showed the association of brachial SBP with LVMi [β ± standard error (SE) 3.47 × 10-2 ± 6.39 × 10-3 g/m2.7/mmHg] and central SBP with LVMi (β ± SE = 3.52 × 10-2 ± 6.40 × 10-3 g/m2.7/mmHg) were comparable (P < 0.001 both). In longitudinal analysis, associations between the changes in BP and changes in LVMi were identical for both central and brachial SBP (β ± SE = 0.011 ± 0.003 g/m2.7/mmHg; P < 0.001 both). Findings were unchanged if participants were stratified by age, LVMi quartile, BP category or central BP phenotype.Conclusion: Changes over time in standard brachial BP provide similar information to central BP on changes over time in LVMi. Whether these findings are generalizable must be further investigated in other cohorts and by other types of central BP devices.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure phenotypes and day-night variability in acute ischemic stroke: is there any cardiovascular mortality link 10 years after?

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-01-24 DOI: 10.1097/HJH.0000000000003976

Christina Antza, Vasilios Kotsis

{"title":"Blood pressure phenotypes and day-night variability in acute ischemic stroke: is there any cardiovascular mortality link 10 years after?","authors":"Christina Antza, Vasilios Kotsis","doi":"10.1097/HJH.0000000000003976","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003976","url":null,"abstract":"Objective: Blood pressure (BP) phenotypes and day-night variability have been associated with acute ischemic stroke (AISTR). The aim of this study was to analyze the BP phenotypes and day-night variability during the first 3 days of an AISTR and their correlation with 10-year cardiovascular death (CVD).Methods: Eighty-five volunteers (49.9% men, 77.3 ± 6 years), diagnosed for AISTR, were included in the study. Twenty-four hour ABPM was performed during the first 3 days of AISTR symptoms. A follow-up visit was performed through phone call, 10 years after the AISTR event.Results: There is a reproducible nocturnal circadiac rhythm, with the nondipping status to be the most prevalent (89.3%, 89.2%, 88.3% for Days 1, 2, 3 accordingly, P > 0.05), compared to dipping status (P < 0.05), but not a reproducible BP phenotype, except the hypertensive one (50%, 45.8%, 51.6% for Days 1, 2 and 3 accordingly, P > 0.05). The mean follow-up was 509.6 ± 10 weeks. 37.1% had died (41.2% from MACE). Cox regression analysis revealed that age [odds ratio (OR):1.15, confidence interval (CI): 1.01-1.17, P < 0.05], sex (male, OR: 1.92, CI: 1.07-3.82, P < 0.05), diabetes mellitus (OR: 1.55, CI: 1.06-3.14, P < 0.05), early vascular ageing (OR: 2.01, CI: 1.19-3.74, P < 0.05), transient ischemic attack (OR: 2.32, CI: 1.02-5.34, P < 0.05), sustained hypertension (OR: 2.78, CI: 1.13-6.83, P < 0.05), day-night SBP ratio (OR: 0.98, CI: 0.96-0.99, P < 0.05) and day-night DBP ratio (OR: 0.96, CI: 0.94-0.99, P < 0.05) were significant predictors for CVD.Conclusion: Hence, patients with AISTR present a reproducible nocturnal circadian rhythm, but not a reproducible BP phenotype, except sustained hypertension. These parameters found also to be determinants for 10-year CVD.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central pulse pressure, carotid artery remodeling and coronary artery calcifications.

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-01-23 DOI: 10.1097/HJH.0000000000003968

Michaela Kozakova, Carmela Morizzo, Giuli Jamagidze, Sara Chiappino, Dante Chiappino, Michele Emdin, Carlo Palombo

{"title":"Central pulse pressure, carotid artery remodeling and coronary artery calcifications.","authors":"Michaela Kozakova, Carmela Morizzo, Giuli Jamagidze, Sara Chiappino, Dante Chiappino, Michele Emdin, Carlo Palombo","doi":"10.1097/HJH.0000000000003968","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003968","url":null,"abstract":"Objectives: The aim of the study was to evaluate the role of central pulse pressure (PP) in carotid wall thickening and coronary artery calcification (CAC).Methods: In an asymptomatic general population (N = 396, 163 men, 47-89 years), central PP was measured by applanation tonometry, CAC by computed tomography, and common carotid artery intima-media thickness (cIMT), pulse wave velocity (cPWV) and the power of the signal reflected from carotid media (cMP) by radiofrequency-based carotid ultrasound. High cIMT was defined as cIMT equal to or greater than the 75th percentile for given sex and age, and CAC presence as a CAC score greater than 0.Results: In the entire population, luminal diameter and cMP increased with increasing central PP (r = 0.32 and 0.25; P < 0.0001). One hundred and ninety-seven individuals had high cIMT; individuals with high cIMT had higher central PP, luminal diameter, cMP and cPWV (P = or <0.0001), but comparable wall tensile stress (P = 0.23). In a logistic regression model, high cIMT was independently associated with luminal diameter and central PP. One hundred and fifty-two individuals had CAC score greater than 0; in a logistic regression model, CAC score greater than 0 was independently associated with sex, age, central PP, LDL-cholesterol, triglycerides and T2DM.Conclusion: Our findings indicate that high central PP contributes both to an increase in cIMT and the development of CAC. However, while central PP was the only risk factor linked to high cIMT, multiple atherosclerotic risk factors were associated with CAC. Therefore, both high cIMT and CAC reflect the adverse impact of high pulsatile load on the vascular system, yet only CAC can be considered a marker of atherosclerosis.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased arterial stiffness and left ventricular remodelling as markers of masked hypertension: findings from the PAMELA population.

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-01-23 DOI: 10.1097/HJH.0000000000003970

Cesare Cuspidi, Rita Facchetti, Elisa Gherbesi, Fosca Quarti-Trevano, Jennifer Vanoli, Giuseppe Mancia, Guido Grassi

{"title":"Increased arterial stiffness and left ventricular remodelling as markers of masked hypertension: findings from the PAMELA population.","authors":"Cesare Cuspidi, Rita Facchetti, Elisa Gherbesi, Fosca Quarti-Trevano, Jennifer Vanoli, Giuseppe Mancia, Guido Grassi","doi":"10.1097/HJH.0000000000003970","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003970","url":null,"abstract":"Background: The value of the association of arterial stiffness with left ventricular concentric remodelling/left ventricular hypertrophy (LVH) assessed by echocardiography, for prediction of masked hypertension defined by office and ambulatory blood pressure monitoring (ABPM) in the general population is largely undefined. We investigated this topic in the participants to the Pressioni Monitorate E Loro Associazioni (PAMELA) study.Methods: The study included 272 participants (153 normotensives and 119 with masked hypertension) who attended the second and third survey of the PAMELA study performed after 10 and 25 years from the initial evaluation. Data collection included medical history, physical examination, blood tests, office, ABPM, echocardiographic and Cardio-Ankle Vascular Index (CAVI) measurements.Results: Compared to normotensive individuals, participants with masked hypertension were younger, had significantly higher office, home, mean 24-h, day-time, night-time SBP/DBP and heart rate. The likelihood of having masked hypertension, was approximately more than two-fold higher [odds ratio (OR) = 2.29, confidence interval (CI): 1.01-5.31, P = 0.04] in participants with increased CAVI and left ventricular remodelling/LVH compared to their counterparts without organ damage. This association showed a unique value in identifying masked hypertension compared to both isolated markers of organ damage (OR = 1.69, P = 0.15 for increased CAVI and OR = 0.82, P = 0.80 for left ventricular remodelling/LVH), after adjusting for age, sex, office SBP/DBP, antihypertensive treatment and diabetes.Conclusion: The present study offers a new piece of evidence of the key value of looking for both vascular and cardiac organ damage to unmask MH and improve its clinical management in the general population.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0