Journal of Hypertension最新文献

{"title":"Differential associations between kidney and vascular health biomarkers in young adults stratified by blood pressure status: The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension study.","authors":"Anja Degenaar, Ruan Kruger, Adriaan Jacobs, Marlien Pieters, Catharina Mc Mels","doi":"10.1097/HJH.0000000000004051","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004051","url":null,"abstract":"<p><strong>Objective: </strong>Hypertension and kidney disease share common pathophysiological pathways involved in endothelial dysfunction including increased oxidative stress and chronic inflammation. The precise early-stage mechanisms associated with nephron-specific kidney injury remain unclear. We aimed to explore associations of kidney function biomarkers with markers representing these mechanisms in young adults stratified by blood pressure status [according to 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guidelines].</p><p><strong>Methods: </strong>We cross-sectionally analysed 1055 adults. Kidney biomarkers included estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (uACR), alpha-1 microglobulin (uA1M), neutrophil gelatinase-associated lipocalin (uNGAL), uromodulin (uUMOD) and CKD273 classifier. Markers of oxidative stress [gamma-glutamyl transferase (GGT); malondialdehyde (MDA)], inflammation [interleukin 6 (IL-6); C-reactive protein (CRP); fibrinogen] and endothelial function [soluble intercellular adhesion molecule-1; soluble vascular cell adhesion molecule-1 (sVCAM-1); von Willebrand factor antigen (vWFag); monocyte chemoattractant protein-1 (MCP-1); plasminogen activator inhibitor-1 activity (PAI-1act); urinary nitrate-to-nitrite ratio] were analysed.</p><p><strong>Results: </strong>Individuals in the hypertensive group (mean age 24.8 years; 73.2% men; 39% Black) had higher GGT, CRP, IL-6, MCP-1 and PAI-1act levels (all P ≤ 0.024) compared to their normotensive counterparts. In individuals with hypertension, eGFR associated negatively and uNGAL positively with IL-6, while uA1M associated positively with PAI-1act (all P ≤ 0.047). In the same group, UMOD associated positively with fibrinogen and CKD273 classifier negatively with MCP-1 (all P ≤ 0.021). In contrast, eGFR associated positively with MDA and negatively with GGT, CKD273 classifier associated positively with GGT, sVCAM-1 and vWFag, and uACR associated negatively with CRP (all P ≤ 0.033) in normotensives.</p><p><strong>Conclusion: </strong>In young adults, mechanisms linked to early nephron-specific kidney injury biomarkers differ according to blood pressure status.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum adiponectin and risk of incident hypertension: the REGARDS study.","authors":"Aneesh M Singal, Virginia J Howard, Suzanne E Judd, April P Carson, Neil A Zakai, Nels C Olson, Mary Cushman, Timothy B Plante","doi":"10.1097/HJH.0000000000004057","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004057","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a cardiovascular disease risk factor disproportionately affecting Black adults. Adiponectin is a cytokine secreted by adipocytes that improves insulin sensitivity, maintains vascular homeostasis, and is inversely associated with adiposity. We sought to determine the risk of incident hypertension by level of adiponectin.</p><p><strong>Methods: </strong>The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 adults from 2003 to 2007. We included REGARDS participants in the Biomarkers as Mediators of Racial Disparities in Risk Factors (BioMedioR) substudy. We estimated the risk ratio for incident hypertension in unadjusted and adjusted models for demographics factors, dietary patterns, measures of adiposity, and SBP.</p><p><strong>Results: </strong>Inverse odds ratio weighting estimated the excess hypertension incidence among Black participants that was explained by adiponectin. Of the 1498 BioMedioR participants, 35% developed incident hypertension in follow-up. White adults had higher baseline adiponectin levels than Black adults. For each 1-SD higher log adiponectin, the risk ratio of hypertension was 0.90 [95% confidence interval (95% CI) 0.84-0.96] in an unadjusted model, 0.92 (0.86-1.00) in a demographic adjusted model, and 0.99 (0.91-1.07) in a fully adjusted model. Lower adiponectin mediated 21-46% of the excess risk of incident hypertension among Black relative to White participants in models adjusting for just demographics and dietary patterns.</p><p><strong>Conclusion: </strong>Among Black and White adults, lower adiponectin was associated with a greater risk of incident hypertension in unadjusted and minimally adjusted models. Future studies into how adiponectin changes in obesity could help to further explain its impact on hypertension risk.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of systemic hypertension on retinal layers in patients without retinopathy.","authors":"Gayathri Jagadesh, Rajalakshmi A R, Swathi Nagarajan","doi":"10.1097/HJH.0000000000004042","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004042","url":null,"abstract":"<p><strong>Objective: </strong>Retinal neuronal damage can be recorded as thinning of inner layers of retina using optical coherence tomography (OCT). This study aimed to determine the effect of systemic hypertension (HTN) on the inner retinal layers in patients without clinically evident hypertensive retinopathy.</p><p><strong>Methodology: </strong>This cross-sectional observational study used spectral domain OCT to measure the thickness of the peripapillary and macular retinal nerve fibre layer (pRNFL and mRNFL) thickness as well as macular ganglion cell-inner plexiform layer (mGC-IPL) thickness in HTN patients without retinopathy. These measurements were compared with age-matched and sex-matched controls.</p><p><strong>Results: </strong>Fifty HTN patients without retinopathy and 50 age-sex matched controls (p > 0.05) were included in the study. The pRNFL, mRNFL and mGC-IPL thickness in HTN group were 98.9 ± 6.29, 34.62 ± 3.98 and 63.57 ± 4.61 μm, respectively. This was significantly reduced when compared to controls [113.04 ± 6.94 μm (p = 0.001); 36.50 ± 5.26 μm (p = 0.047); 68.04 ± 4.60 μm (p = 0.001) respectively]. A significant reduction in pRNFL (p = 0.003) and mGC-IPL (p = 0.007) was noted with increased duration of HTN. Sex, family history of HTN, Type of anti-HTN medication did not seem to affect the inner retinal thickness in our study (p > 0.05).</p><p><strong>Conclusion: </strong>Hypertensive patients without retinopathy showed significant thinning of the pRNFL, mRNFL and mGC-IPL when compared to the controls. Longer duration of hypertension was associated with greater thinning of inner retinal layers.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring early vascular aging in youth: an expert consensus document from the Youth Vascular Consortium.","authors":"Jeanne Hersant, Ruan Kruger, Elisabetta Bianchini, Karsten Königstein, Manish D Sinha, Erzsébet V Hidvégi, Vimarsha Kodithuwakku, José Geraldo Mill, Alejandro Diaz, Yanina Zócalo, Daniel Bia, David Celermajer, Henner Hanssen, Madeleine Johansson, Giacomo Pucci, Mieczysław Litwin, Keeron Stone, Christopher J A Pugh, Lee Stoner, Elaine M Urbina, Rosa Maria Bruno, Peter M Nilsson, Rachel E Climie","doi":"10.1097/HJH.0000000000004039","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004039","url":null,"abstract":"<p><p>Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with these biomarkers in youth, a standardized approach for clinical evaluation of EVA remains elusive, leaving pertinent gaps in understanding the optimal methodology. This article, resulting from international consensus efforts from the Youth Vascular Consortium, aims to provide an updated overview of methods available to measure EVA in youth and to discuss challenges in translating these methods into clinical practice.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermoneutral-housed rats demonstrate impaired perivascular adipose tissue and vascular crosstalk.","authors":"Melissa M Henckel, Ji Hye Chun, Leslie A Knaub, Gregory B Pott, Georgia E James, Kendall S Hunter, Robin Shandas, Lori A Walker, Jane E-B Reusch, Amy C Keller","doi":"10.1097/HJH.0000000000003948","DOIUrl":"10.1097/HJH.0000000000003948","url":null,"abstract":"<p><strong>Objective: </strong>Vascular pathology, characterized by impaired vasoreactivity and mitochondrial respiration, differs between the sexes. Housing rats under thermoneutral (TN) conditions causes vascular dysfunction and perturbed metabolism. We hypothesized that thoracic perivascular adipose tissue (tPVAT), a vasoregulatory adipose depot known to have a brown adipose tissue (BAT) phenotype, remodels to a mainly white adipose (WAT) phenotype in rats housed at TN, driving diminished vasoreactivity in a sex-dependent manner.</p><p><strong>Methods: </strong>Male and female Wistar rats were housed at either room temperature (RT) or TN. We measured changes in tPVAT morphology, vasoreactivity in vessels with intact tPVAT or transferred to tPVAT of the oppositely-housed animal, vessel stiffness, vessel mitochondrial respiration and cellular signaling.</p><p><strong>Results: </strong>Remodeling of tPVAT was observed in rats housed at TN; animals in this environment showed tPVAT whitening and displayed diminished aortae vasodilation ( P  < 0.05), different between the sexes. Juxtaposing tPVAT from RT rats onto aortae from TN rats in females corrected vasodilation ( P  < 0.05); this did not occur in males. In aortae of all animals housed at TN, mitochondrial respiration was significantly diminished in lipid substrate experiments ( P  < 0.05), and there was significantly less expression of phosphorylated endothelial nitric oxide synthase (peNOS) ( P  < 0.001).</p><p><strong>Conclusions: </strong>These data are consistent with TN-induced remodeling of tPVAT, notably associated with sex-specific blunting of vasoreactivity, diminished mitochondrial respiration, and altered cellular signaling.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"752-767"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of left ventricular ejection fraction on cardiovascular and renal outcome in hypertensive patients with nondialysis chronic kidney disease.","authors":"Ernesto Paoletti, Chiara Ruotolo, Federica Marzano, Silvio Borrelli, Carlo Garofalo, Paolo Chiodini, Laura Pieracci, Mariano Mij, Carmela Iodice, Luca De Nicola, Maura Ravera, Roberto Minutolo","doi":"10.1097/HJH.0000000000004000","DOIUrl":"10.1097/HJH.0000000000004000","url":null,"abstract":"<p><strong>Objectives: </strong>Identification of nondialysis chronic kidney disease (CKD) patients at a higher risk of end-stage kidney disease (ESKD) or adverse cardiovascular events is the first essential step to optimize management. We evaluated the role of left ventricular ejection fraction (LVEF) in predicting cardiac and renal outcome in CKD.</p><p><strong>Methods: </strong>We prospectively studied 580 consecutive patients with nondialysis CKD followed in two Italian renal clinics in order to evaluate the association between LVEF as either continuous variable or categories (>60, 50-60 and <50%) and adjusted risks (hazard ratio, 95% confidence interval) of either cardiovascular (composite of fatal and nonfatal cardiovascular events) or renal events (composite of ESKD and all-cause death before ESKD).</p><p><strong>Results: </strong>The mean age of participants was 65.0 ± 13.5 years, 62% men, eGFR 41.3 ± 21.1 ml/min/1.73 m 2 , LVEF 60.6 ± 8.1% and left ventricular mass index (LVMI) 59.3 ± 17.6 g/m 2.7 . LVEF more than 60%, 50-60% and <50% was recorded in 274, 234 and 72 patients, respectively. Patients with LVEF less than 50% were predominantly men with more frequent history of cardiovascular disease and lower eGFR; in addition, they had higher 24 h, daytime and nighttime blood pressure. During the follow-up (median 5.0 years, IQR 4.9-7.1), cardiovascular and renal endpoints were registered in 113 and 228 patients, respectively. LVEF as a continuous variable was inversely associated with the adjusted risk of either cardiovascular (0.97, 0.95-0.99) or renal endpoint (0.98, 0.97-0.995). In comparison with patients with LVEF more than 60%, the risk of cardiovascular events was increased in patients with LVEF 50-60% (1.64, 1.06-2.53) and less than 50% (2.17, 1.27-3.72). The same occurred for renal endpoint (1.68, 1.24-2.27 and 1.73, 1.15-2.59 for LVEF 50-60% and <50%, respectively).</p><p><strong>Conclusion: </strong>In CKD patients, lower LVEF is associated with worse cardiorenal prognosis, independently from LVMI.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"897-903"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemodynamic changes from prepregnancy to very early pregnancy among women planning to conceive in Southwestern Uganda.","authors":"Henry M Lugobe, Carmel M Mceniery, Musa Kayondo, Janet M Catov, Joseph Ngonzi, Charles Batte, Bonnie Wandera, Bruce Kirenga, Blair J Wylie, Adeline A Boatin, Kwame Adu-Bonsaffoh, David C Agaba, Ian B Wilkinson","doi":"10.1097/HJH.0000000000003988","DOIUrl":"10.1097/HJH.0000000000003988","url":null,"abstract":"<p><strong>Introduction: </strong>Normal pregnancy is associated with cardiovascular changes that enable adaptation to the pregnancy state. We sought to describe the haemodynamic changes from prepregnancy to very early pregnancy in women planning to conceive in southwestern Uganda.</p><p><strong>Methods: </strong>In this prospective cohort study, we enrolled women in southwestern Uganda planning to conceive. Brachial and central blood pressure, heart rate, cardiac output, stroke volume, and peripheral vascular resistance were assessed prepregnancy and repeated in very early pregnancy.</p><p><strong>Results: </strong>We studied 86 women with a mean age of 27.8 years (SD ± 4.4). The mean gestational age was 7 (±2) weeks at the time of repeat blood pressure measurement. Brachial systolic and diastolic blood pressure decreased in very early pregnancy (116 ± 11 to 114 ± 8 mmHg and 68 ± 6 to 65 ± 5 mmHg, respectively; P  < 0.001). Central systolic and diastolic blood pressure also decreased (112 ± 10 to 109 ± 8 mmHg, P  = 0.003 and 68 ± 6 to 65 ± 5 mmHg, P  < 0.001, respectively), as did peripheral vascular resistance (1450 ± 581 to 1311 ± 276 dyn/s/cm 5P  = 0.038). There was no significant difference in cardiac output (5.3 ± 1.2 vs 5.5 ± 1.1 l/min P  = 0.146) or stroke volume (64 ± 13 to 66 ± 12 ml, P  = 0.172).</p><p><strong>Conclusion: </strong>Significant haemodynamic changes occur in very early pregnancy. Using late first trimester measurements as a baseline for pregnancy induced changes may not be suitable for understanding the full extent of pregnancy induced haemodynamic changes, or provide a reliable substitute for prepregnancy states.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"859-863"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Prof. George Fodor (1927 - 2024).","authors":"Renata Cífková","doi":"10.1097/HJH.0000000000003992","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003992","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 5","pages":"914-915"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothesis: Reactive increases in plasma renin activity attenuate the fall in blood pressure caused by salt depletion and renin-angiotensin system inhibition.","authors":"Jean E Sealey, Jon D Blumenfeld","doi":"10.1097/HJH.0000000000003964","DOIUrl":"10.1097/HJH.0000000000003964","url":null,"abstract":"<p><p>There are inconsistencies in the effect of raising or lowering body salt on blood pressure (BP). We hypothesize that they are caused in part by differences in plasma renin activity (PRA). PRA changes reciprocally with body salt. PRA is the rate limiting step in the formation of the vasoconstrictor peptide angiotensin II (Ang II) in the circulation where it cleaves Ang I from plasma angiotensinogen, and then Ang I is rapidly converted to Ang II by angiotensin-converting enzyme in plasma and vascular endothelial cells. We hypothesize that PRA levels above 0.65 ng/ml/h lead to sufficient Ang II production to cause vasoconstriction, whereas lower levels do not. PRA is usually more than 0.65 in normotensives who are not on a high-salt diet; in them, the increase in PRA/Ang II vasoconstriction caused by reduction in body salt (low-salt diet, diuretic use) is large enough to prevent BP from falling. By contrast, a similar reduction in body salt lowers BP in the 30% of hypertensive patients with low baseline PRA (<0.65 ng/ml/h), because vasoconstriction does not increase in that range. A similar reduction in body salt also lowers BP in the 60% of hypertensive patients with baseline PRA between 0.65 and 4.5 ng/ml/h, but for a different reason; the rise in PRA and the increase in vasoconstriction is too small to prevent BP from falling. However, after body salt has been reduced enough to raise PRA above 4.5 ng/ml/h, further salt depletion increases PRA to a greater extent, and BP does not fall. Renin-angiotensin system (RAS) inhibitors leave a small amount of renin unblocked. In salt-depleted hypertensive patients, they also raise PRA enough to prevent BP from falling significantly. We propose that this PRA/Ang II vasoconstrictor effect related to reactive increases in PRA can prevent or attenuate the decrease in BP caused by excessive salt depletion, even during concurrent RAS inhibition. This phenomenon, if confirmed, could inform new strategies to optimize the treatment of hypertension, cardiovascular disease (CVD) and chronic kidney disease (CKD).</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"739-746"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of new onset arterial hypertension after metabolic bariatric surgery: an 8-year prospective follow-up with matched controls.","authors":"Viiko Vahtera, Jukka S Pajarinen, Mika Kivimäki, Jenni Ervasti, Jaana Pentti, Sari Stenholm, Jussi Vahtera, Paulina Salminen","doi":"10.1097/HJH.0000000000003993","DOIUrl":"10.1097/HJH.0000000000003993","url":null,"abstract":"<p><strong>Background: </strong>Metabolic bariatric surgery (MBS) reduces the risk of new-onset hypertension; however, it is unclear whether this effect varies according to patient sex, age, or socioeconomic background. This study aimed to assess the risk of new-onset arterial hypertension after MBS, with a special focus on these patient characteristics.</p><p><strong>Methods: </strong>This follow-up study with matched controls was nested in a large employee cohort, the Finnish Public Sector study, consisting of individuals with no hypertension at baseline. For each patient who underwent laparoscopic MBS between 2008 and 2016, two propensity-score matched controls were selected from individuals hospitalized with a diagnosis of obesity or individuals with self-reported severe obesity [body mass index (BMI) ≥ 35 kg/m 2 ] but no recorded history of MBS. Cases of new-onset hypertension were identified via linked electronic health records from the national health registries until December 31, 2016.</p><p><strong>Results: </strong>The study included 912 patients and 1780 matched controls. The rate of new-onset hypertension per 1000 person-years was 2.8 in the surgery group and 9.6 in the control group, with a rate ratio of 0.29 (95% confidence intervals 0.15-0.57) and a rate difference of -6.8 (95% confidence intervals -9.6 to -4.0) per 1000 person-years. No significant differences in rate reduction after MBS were observed to be associated with patient sex, age, or socioeconomic status.</p><p><strong>Conclusion: </strong>Metabolic bariatric surgery reduces the risk of new-onset arterial hypertension across all age-, sex-, and socioeconomic subgroups.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"871-879"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}