Journal of Hypertension最新文献

{"title":"Erratum: Immune profiles in KCNJ5-mutant aldosterone-producing adenomas: pilot characterisation of age and gender differences.","authors":"","doi":"10.1097/HJH.0000000000004096","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004096","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 9","pages":"1603"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LASSO logistic regression and cluster analysis in predicting adherence and drug patterns among new users of monotherapy for antihypertensive drugs.","authors":"Xuechun Li, Mutiara Djayanis Tia, Jens H J Bos, Catharina C M Schuiling-Veninga, Eelko Hak, Sumaira Mubarik","doi":"10.1097/HJH.0000000000004084","DOIUrl":"10.1097/HJH.0000000000004084","url":null,"abstract":"<p><strong>Objective: </strong>Real-world long-term adherence and drug utilization patterns are essential for hypertension management. However, the evidence was unclear. We aimed to construct adherence and drug patterns risk prediction models.</p><p><strong>Methods: </strong>We designed a retrospective inception cohort study using pharmacy records from the University of Groningen IADB.nl dispensing database. Exposures were antihypertensive drug monotherapy including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium channel blockers, and thiazides. Primary outcomes included adherence rates and drug utilization patterns. Cluster analysis was performed to categorize patients with similar risk factors. Least Absolute Shrinkage and Selection Operator logistic regression was then employed to construct prediction models.</p><p><strong>Results: </strong>The adherence rate in the 1 st year to the 10 th year increased from 86.4% to 92.9%. Most monotherapies, middle and older age, with initial diabetes, asthma/ chronic-obstructive-pulmonary-disease drug, and without psycholeptics drug, first exposure prescription after 2000 promoted high adherence. Thiazides and being male were harmful to continuation and helpful to discontinuation, switching and adding on. Middle and older age promoted switching and adding on but impeded discontinuation. High adherence contributed to continuation, switching and adding on but impeded discontinuation. Thiazides were better for the short term use to achieve high adherence while calcium channel blockers in both short term and long term were better to achieve high adherence than beta-blockers.</p><p><strong>Conclusions: </strong>The results highlighted key factors influencing medication adherence and treatment changes, emphasizing the need for personalized approaches to optimize patient care. Enhancing adherence and provide specific monotherapy for short term and long term plan were beneficial to better personalized treatment.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1519-1528"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure.","authors":"Karita C F Lidani, Shubham Tomar, Hossein Mousavi, Robert Buscaglia, Kirolos Michael, Alexander P Landry, Leonie Dupuis, Erin D Michos, Erin S Morgan, Xiuqing Guo, Jie Yao, Henry J Lin, Jerome I Rotter, Wendy S Post, Sotirios Tsimikas, Patrick J Trainor, Andrew P DeFilippis","doi":"10.1097/HJH.0000000000004080","DOIUrl":"10.1097/HJH.0000000000004080","url":null,"abstract":"<p><strong>Objective: </strong>The renin angiotensin aldosterone system plays a key role in circulatory homeostasis. We sought to identify genetic determinants of measured plasma angiotensinogen levels and subsequently evaluate the association of these single nucleotide polymorphisms (SNPs) with blood pressure (BP) and hypertension in a multiethnic population.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) of plasma angiotensinogen levels, measured using an enzyme-linked immunoassay, was conducted in 4899 Multi-Ethnic Study of Atherosclerosis (MESA) participants (self-identified as White, n = 1865; Hispanic, n  = 1113; Black, n  = 1224; and Chinese, n  = 629). Linear and logistic models examined the association between SNPs with angiotensinogen and hypertension, respectively. Mediation analysis evaluated the effect of angiotensinogen on BP/hypertension through the top SNPs identified by GWAS.</p><p><strong>Results: </strong>In the analysis utilizing all participants, 115 SNPs were associated with angiotensinogen ( P  < 5 × 10 -8 ), including lead SNP rs4762(G>A) in exon 2 ( P  = 1.51E -100 ) and rs5050(T>G) in the promoter region ( P  = 2.26E -69 ) of the AGT gene. Race/ethnic-specific analyses identified rs4762(G>A) as the lead SNP for White and Hispanic participants, whereas Black and Chinese participants had rs5050(T>G) and rs16852311(G>C), respectively. Both rs4762(G>A) and rs5050(T>G) indirectly increased systolic BP, diastolic BP, and the odds of hypertension through its effect of increasing angiotensinogen.</p><p><strong>Conclusions: </strong>Our findings demonstrate racial/ethnic differences in genetic effects on angiotensinogen levels across multiple SNPs. AGT rs4762(G>A) and rs5050(T>G) impact BP and hypertension through a mediated effect via angiotensinogen, though opposing direct effects may mask the overall association.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1500-1509"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, awareness, and risk factors affecting hypertension according to 2017 American College of Cardiology and American Heart Association guidelines: a cross-sectional study from a developing country.","authors":"Imad Asmar, Omar Almahmoud, Maram Jaghama","doi":"10.1097/HJH.0000000000004089","DOIUrl":"10.1097/HJH.0000000000004089","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a chronic disease prevalent worldwide, with a significant increase in the number of people diagnosed with HTN. This study aimed to determine the prevalence and awareness of HTN among adults in Palestine according to the 2017 American College of Cardiology and American Heart Association guidelines, and to investigate the risk factors affecting HTN.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between August 2024 and November 2024 among residents of West Bank Palestine. A total of 1420 adults aged 18 years and older were recruited using convenience sampling. Data were collected through blood pressure and anthropometric measurements of BMI and waist circumference. A questionnaire was used to gather sociodemographic information, HTN history, physical activity, antihypertensive drug use, and other family history information. Statistical analyses, including chi-square tests and binary logistic regression, were performed.</p><p><strong>Results: </strong>The prevalence of HTN in this study was 60%. Moreover, 46.4% of participants with HTN were unaware of their condition. Several factors were found to be independent predictors of HTN, including smoking [adjusted odds ratio (aOR): 8; 95% confidence interval (CI): 5.1-11.1], older age (aOR: 1.022; 95% CI: 1.01-1.04), and living in urban areas (aOR: 1.9; 95% CI: 1.4-2.5). Conversely, normal BMI (aOR: 0.6; 95% CI: 0.4-0.9) and moderate physical activity (aOR: 0.6; 95% CI: 0.6-0.8) were protective against the development of HTN.</p><p><strong>Conclusion: </strong>Three out of five adults in Palestine had HTN, and approximately half of them were unaware of their condition. The study findings indicate the urgent need for appropriate public health interventions to address awareness, early detection, and modifiable risk factors, which will greatly alleviate the regional HTN burden.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1561-1569"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmeal walking reduces nighttime central SBP and increases nocturnal dipping of SBP in healthy, physically inactive young women.","authors":"Maison P D'Amelio, Ryan L Bonitatibus, Bilal A Chaudhry, John G Dennett, Deborah L Feairheller, Michael S Brian","doi":"10.1097/HJH.0000000000004082","DOIUrl":"10.1097/HJH.0000000000004082","url":null,"abstract":"<p><strong>Introduction: </strong>Postmeal walking (PMW) blunts postprandial blood glucose, but the impact on postexercise hypotension and ambulatory blood pressure (BP) has not been examined in young women. Further, it remains unknown how PMW influences ambulatory central BP among young women.</p><p><strong>Methods: </strong>Fourteen physically inactive, nonhypertensive women (20 ± 1 years; body fat: 28.1 ± 12%) completed the study during the early follicular or placebo phase of their contraceptive cycle. Participants completed a control day (CON; no exercise/excess physical activity) and PMW day (three bouts for 15 min of brisk walking). Ambulatory brachial and central BP (24 h, daytime, nocturnal, postexercise BP, nocturnal dipping) and accelerometry data were collected.</p><p><strong>Results: </strong>PMW reduced 24 h central augmentation pressure (PMW = 9 ± 4 mmHg; CON=10 ± 5 mmHg, P  = 0.049) and central pulse pressure (PMW = 31 ± 3 mmHg; CON=33 ± 4 mmHg, P  = 0.02). PMW also reduced nighttime central augmentation pressure (PMW = 10 ± 4 mmHg; CON = 13 ± 4 mmHg, P  < 0.001) and central pulse pressure (PMW = 35 ± 5 mmHg; CON = 32 ± 3 mmHg, P  = 0.001). PMW induced postexercise hypotension (effect of time: P  < 0.05), but there was no effect of condition ( P  > 0.05 vs. CON), as the CON postprandial state also induced a hypotensive effect. PMW increased heart rate (main effect of condition, P  = 0.01). PMW also increased brachial SBP nocturnal dipping (PMW = 17.5 ± 4.2; CON = 14.4 ± 5.2%, P  < 0.05) and central SBP nocturnal dipping (PMW = 6.8 ± 4.5; CON = 12.2 ± 5.3%, P  < 0.01). Brachial and central DBP nocturnal dipping was not different between conditions (PMW = 23.7 ± 5.9%, CON = 22.3 ± 7%, P  = 0.50; PMW = 25 ± 6.4%, CON = 21.9 ± 5.6%, P  = 0.13, respectively).</p><p><strong>Conclusion: </strong>PMW exerts the greatest influence on nighttime SBP and nocturnal dipping of SBP in young women. PMW also induces a similar hypotensive response that occurs following a meal.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1510-1518"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index and incidence of hypertension, a population-based observational study of the Japanese population.","authors":"Shintaro Ishida, Yukiko Shinohara, Takashi Sakaguchi, Shiori Katsuki, Kazumi Kawano, Tamami Ueno, Kaori Maki, Chihiro Nohara, Takako Fujii, Makiko Abe, Miki Kawazoe, Toshiki Maeda, Chikara Yoshimura, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Shigeaki Mukobara, Kosuke Masutani, Hisatomi Arima","doi":"10.1097/HJH.0000000000004087","DOIUrl":"10.1097/HJH.0000000000004087","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the relationship between the triglyceride-glucose (TyG) index and the incidence of hypertension in a population-based sample of Japanese health check participants.</p><p><strong>Methods: </strong>We conducted a population-based retrospective cohort study using annual health checkup data from residents of Iki City, Nagasaki Prefecture, Japan. In total, 2,600 participants without hypertension at baseline were included in the present analysis. The TyG index was classified as quartile1 (<8.08), quartile2 (8.09-8.43), quartile3 (8.44-8.84) and quartile4 (≥8.85) for men, and as quartile1 (<7.89), quartile2 (7.9-8.22), quartile3 (8.23-8.54) and quartile4 (≥8.55) for women. The outcome measure was the incidence of hypertension.</p><p><strong>Results: </strong>During an average follow-up period of 4.96 years, 789 participants developed hypertension using the Cox proportional hazards model. The annual incidence of hypertension increased with an increase in the TyG index in men (4.79% in quartile1, 6.25% in quartile2, 7.72% in quartile3, and 9.31% in quartile4) and women (3.65% in quartile1, 5.36% in quartile2, 5.55% in quartile3, and 6.96% in quartile4). This association was significant even after adjustment for other risk factors: hazard ratios 1.39 [95% confidence interval (CI) 0.99-1.93] for quartil2, 1.44 (1.03-2.01) for quartile3, 1.79 (1.27-2.52) for quartile4 relative to quartile1 among men ( P  = 0.001 for trend), 1.02 (95% CI 0.74-1.40) for quartile2, 1.04 (0.75-1.41) for quartile3, and 1.02 (0.74-1.42) for quartile4 relative to quartile1 among women ( P  = 0.882 for trend).</p><p><strong>Conclusion: </strong>The TyG index was associated with the future incidence of hypertension in a population-based sample of Japanese men.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1554-1560"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic characteristic impedance-induced increases in forward wave but not central arterial pulse pressure beyond brachial blood pressure in coronary artery disease.","authors":"Vernice R Peterson, Danelle Els, Eitzaz Sadiq, Ravi Naran, Taalib Monareng, Talib Abdool-Carrim, Ismail Cassimjee, Girish Modi, Gavin R Norton, Ferande Peters, Angela J Woodiwiss","doi":"10.1097/HJH.0000000000004094","DOIUrl":"10.1097/HJH.0000000000004094","url":null,"abstract":"<p><strong>Background: </strong>Whether coronary artery disease (CAD) associates with proximal aortic stiffness-induced increases in central arterial forward wave pressures (Pf), but not peak central arterial pulse pressure (PPc) beyond peripheral PP, is uncertain. Therefore, we aimed to investigate the relationship between CAD and aortic characteristic impedance (Zc) and Pf beyond brachial PP and PPc.</p><p><strong>Methods: </strong>From central pressure (SphygmoCor), and aortic velocity and diameter measurements (echocardiography), we compared Zc ( n  = 71) and central arterial pressure wave morphology ( n  = 189) in patients with CAD, to 210 age- and sex-matched controls, and patients with stroke or critical limb ischemia (CLI) ( n  = 287).</p><p><strong>Results: </strong>With adjustments for confounders, including mean arterial pressure and aortic root diameter, Zc was increased in patients with CAD compared to controls and patients with stroke or CLI ( P  < 0.0001). The early systolic pressures generated by the product of peak aortic flow (Q) and Zc (P QxZc ), and Pf were also increased in patients with CAD compared to controls and patients with alternative arterial diseases ( P  < 0.0005). Enhanced P QxZc at peak PPc, rather than increases in re-reflected wave pressures, accounted for increases in Pf. After further adjustments for brachial PP or SBP, the higher Pf values in patients with CAD were retained ( P  < 0.01 to P  < 0.0005). In contrast, although peak PPc was higher in patients with CAD or alternative arterial diseases compared to controls ( P  < 0.05 to P  < 0.0005), these differences were abolished by further adjustments for brachial BP.</p><p><strong>Conclusion: </strong>Increases in stiffness-associated proximal aortic Zc in patients with CAD translate into increases in Pf, but not peak PPc, beyond brachial BP. Hence, the pulsatile load responsible for CAD is beyond brachial BP and poorly indexed by PPc.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1589-1597"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension doesn't cause heart failure. Rethinking heart failure with preserved ejection fraction and hypertensive heart disease.","authors":"Maria Giulia Bellicini","doi":"10.1097/HJH.0000000000004069","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004069","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 9","pages":"1473-1474"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A steep-increasing blood pressure trajectory from early pregnancy is associated with birth outcomes in the EDEN mother-child cohort.","authors":"Briana DeStaffan, Muriel Tafflet, Grégory Lailler, Valérie Olié, Jacques Blacher, Catherine Deneux-Tharaux, Marie-Aline Charles, Barbara Heude, Wen Lun Yuan","doi":"10.1097/HJH.0000000000004083","DOIUrl":"10.1097/HJH.0000000000004083","url":null,"abstract":"<p><strong>Background: </strong>An enhanced consideration of blood pressure (BP) dynamics during pregnancy could improve its monitoring. Distinct BP trajectories may exist, and some have been linked to adverse fetal development. Using maternal BP measurements spanning almost the entire pregnancy, this study aimed to identify trajectories and assess their association with birth outcomes.</p><p><strong>Methods: </strong>Routine BP measurements (median = 8) were extracted from the obstetric records of 1849 mothers from the French EDEN birth cohort. Outcomes included birth weight z-score, prematurity and, for a subsample ( n  = 1377), placental weight and birth weight-to-placental weight ratio. Maternal SBP trajectories were identified by Latent Class Growth Mixture Modeling. Associations with outcomes were analyzed using adjusted linear or logistic regressions.</p><p><strong>Results: </strong>Two BP trajectories were identified: a first U-shaped and a second steep-increasing, comprising 96 and 4% of mothers, respectively. The steep-increasing trajectory reached the hypertensive threshold around 30 weeks of gestation. Over half of mothers in this trajectory had a hypertensive disorder diagnosis, and 24% had preeclampsia. Mothers in this trajectory had newborns with lower birth weight z-scores [β = -0.31, 95% confidence interval (95% CI) = -0.55 to -0.07] and/or increased likelihood of premature delivery (odds ratio = 4.02, 95% CI = 2.04-7.50). No associations were observed with placental outcomes.</p><p><strong>Conclusion: </strong>Our results suggest the existence of a steep-increasing BP trajectory from the first weeks of pregnancy and associated with poorer birth outcomes. Further investigation into this trajectory's determinants could lead to improved hypertensive disorder risk stratification, ultimately aiding in the prevention of related maternal and fetal consequences.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1492-1499"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of the spleen in the development of arterial hypertension in humans.","authors":"Matteo Nardin, Claudia Agabiti Rosei, Claudia Rossini, Fabio Bertacchini, Silvia Piantoni, Valeria Brami, Giulia Chiarini, Paolo Malerba, Niccolò Piacentini, Samantha Sartori, Silvia Ministrini, Antonella Anastasia, Mariella D'Adda, Enzo Porteri, Paolo Airò, Guido Alberto Massimo Tiberio, Giuseppe Rossi, Franco Franceschini, Damiano Rizzoni, Carolina De Ciuceis","doi":"10.1097/HJH.0000000000004115","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004115","url":null,"abstract":"<p><strong>Objectives: </strong>Immunity, particularly T lymphocytes, plays an important role in the development of arterial hypertension. Moreover, the so-called neuro-immune axis has been identified as a crucial crossroads, occurring in the spleen and involving placental growth factor as the principal mediator. However, no studies in humans have yet investigated the role of the spleen in hypertension and vascular damage.</p><p><strong>Methods: </strong>In this retrospective, case-control, single-blind study, we enrolled patients who had previously undergone elective splenectomy (cases) and subjects who had undergone elective cholecystectomy (controls). All subjects underwent 24-h ambulatory blood pressure monitoring, evaluation of retinal arteriole morphology by adaptive optics, capillary density assessment by video-capillaroscopy, arterial stiffness measurements, and analysis of T lymphocyte subpopulations by flow cytometry.</p><p><strong>Results: </strong>Fifty patients were included: 25 (50%) cases and 25 (50%) controls. No difference in hypertension prevalence (P = 0.39) or cumulative incidence (P = 0.79) of new diagnoses was detected. Splenectomized patients displayed lower 24-h (P = 0.024) and daytime (P = 0.011) diastolic blood pressure compared to cholecystectomized patients. Similar results were obtained for retinal structural parameters, capillary density, and arterial stiffness between the groups. A significant impact of splenectomy on the relationship between 24-h diastolic BP and wall cross-sectional area (P-interaction = 0.019) and forearm capillary density recruitment (P-interaction = 0.020) was found. A higher number and percentage of CD3+CD8+ T cells were observed in splenectomized patients compared to cholecystectomized patients (P = 0.009 and P = 0.001, respectively), although no differences in cytokine production patterns were detected.</p><p><strong>Conclusions: </strong>For the first time, our results support the role of the spleen in blood pressure control in humans. Further and larger studies are required to appropriately translate our findings into clinical practice.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}