Journal of Hypertension最新文献

{"title":"Effect of systemic hypertension on retinal layers in patients without retinopathy.","authors":"Gayathri Jagadesh, Rajalakshmi A R, Swathi Nagarajan","doi":"10.1097/HJH.0000000000004042","DOIUrl":"10.1097/HJH.0000000000004042","url":null,"abstract":"<p><strong>Objective: </strong>Retinal neuronal damage can be recorded as thinning of inner layers of retina using optical coherence tomography (OCT). This study aimed to determine the effect of systemic hypertension (HTN) on the inner retinal layers in patients without clinically evident hypertensive retinopathy.</p><p><strong>Methodology: </strong>This cross-sectional observational study used spectral domain OCT to measure the thickness of the peripapillary and macular retinal nerve fibre layer (pRNFL and mRNFL) thickness as well as macular ganglion cell-inner plexiform layer (mGC-IPL) thickness in HTN patients without retinopathy. These measurements were compared with age-matched and sex-matched controls.</p><p><strong>Results: </strong>Fifty HTN patients without retinopathy and 50 age-sex matched controls ( p  > 0.05) were included in the study. The pRNFL, mRNFL and mGC-IPL thickness in HTN group were 98.9 ± 6.29, 34.62 ± 3.98 and 63.57 ± 4.61 μm, respectively. This was significantly reduced when compared to controls [113.04 ± 6.94 μm ( p  = 0.001); 36.50 ± 5.26 μm ( p  = 0.047); 68.04 ± 4.60 μm ( p  = 0.001) respectively]. A significant reduction in pRNFL ( p  = 0.003) and mGC-IPL ( p  = 0.007) was noted with increased duration of HTN. Sex, family history of HTN, Type of anti-HTN medication did not seem to affect the inner retinal thickness in our study ( p  > 0.05).</p><p><strong>Conclusion: </strong>Hypertensive patients without retinopathy showed significant thinning of the pRNFL, mRNFL and mGC-IPL when compared to the controls. Longer duration of hypertension was associated with greater thinning of inner retinal layers.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1367-1372"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational glucocorticoid exposure impaired endothelial nitric oxide synthesis via downregulating IP3 receptor 3 expression in male offspring vessels.","authors":"Jiahui Lei, Fengying Deng, Junlan Qiu, Chenxuan Zhao, Meihua Zhang, Qinqin Gao","doi":"10.1097/HJH.0000000000004067","DOIUrl":"10.1097/HJH.0000000000004067","url":null,"abstract":"<p><strong>Background: </strong>Antenatal glucocorticoid administration represents a standard therapeutic intervention for preterm birth; however, its long-term consequences on vascular endothelial function in offspring remain poorly understood. Nitric oxide (NO), the principal vasodilator secreted by vascular endothelial cells (VECs), plays a pivotal role in vascular pathophysiology when its biosynthesis is dysregulated. This investigation elucidates the effects and underlying mechanisms of gestational exposure to clinically relevant glucocorticoid doses on endothelial NO synthesis in offspring.</p><p><strong>Methods and results: </strong>Pregnant Sprague-Dawley rats were administered dexamethasone (DEX), a synthetic glucocorticoid, during the final gestational week. Thoracic aorta specimens from both fetal and adult offspring were isolated for experimentation. Gestational DEX exposure markedly attenuated NO-dependent acetylcholine-induced vasodilation in thoracic aorta rings from both fetal and adult male offspring. Furthermore, acetylcholine-stimulated NO synthesis was significantly impaired in VECs derived from DEX-exposed offspring thoracic aorta. Mechanistic investigations revealed that gestational DEX exposure diminished endothelial NO synthesis capacity in offspring, primarily through downregulation of inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) expression. Notably, gestational DEX-induced epigenetic reprogramming of IP3R3 gene expression appears to be mediated by alterations in DNA methylation status, ultimately disrupting the IP3R3/Ca 2+ /NO synthase signaling cascade in offspring VECs and predisposing to long-term vascular dysfunction through impaired NO biosynthesis.</p><p><strong>Conclusion: </strong>This study provides the first experimental evidence that gestational glucocorticoid exposure compromises endothelial NO synthesis in offspring vasculature through epigenetic reprogramming of IP3R3 gene expression. These novel findings demonstrate that the detrimental effects of antenatal glucocorticoid exposure on fetal vascular function persist into adulthood, offering critical insights into the developmental origins of vascular disease pathogenesis.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1423-1435"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor Alan G. Jardine: 27th August 1960-3rd April 2025, aged 64.","authors":"Adrian J B Brady, Christian Delles, Patrick B Mark, Thomas M MacDonald","doi":"10.1097/HJH.0000000000004063","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004063","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1460-1462"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the hypertension-kidney connection: implications for black communities.","authors":"Carmine Zoccali, Francesca Mallamaci","doi":"10.1097/HJH.0000000000004059","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004059","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1322-1324"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of hypertension after preeclampsia: the enigma remains alive.","authors":"Ilektra Oikonomopoulou, Olga Kourti, Aliki Zografou, Rafaella Paparidou, Ioannis Vaseiliadis, Costas Platanias, Eftichia Michalaki, Elias Sanidas, Costas Thomopoulos","doi":"10.1097/HJH.0000000000004071","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004071","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1459"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'4 Ss' for successful blood pressure control.","authors":"Ian B Wilkinson, Sarah Partridge, Peter Sever","doi":"10.1097/HJH.0000000000004054","DOIUrl":"10.1097/HJH.0000000000004054","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1319-1321"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension in children with intellectual disabilities: a population not to be overseen.","authors":"Justyna Wyszyńska, Edyta Łuszczki, Tomas Seeman, Giacomo D Simonetti, Olena Nyankovska, Małgorzata Wójcik, Agnieszka Kozioł-Kozakowska, Aliki Peletidi, Artur Mazur, Julio Alvarez-Pitti, Empar Lurbe","doi":"10.1097/HJH.0000000000004052","DOIUrl":"10.1097/HJH.0000000000004052","url":null,"abstract":"<p><p>Hypertension (HTN) is a significant public health concern affecting individuals across all age groups, including those with and without disabilities. Among children and adolescents, particularly those with intellectual disabilities, the risk of HTN is heightened due to factors such as obesity, low physical activity, and comorbid conditions. Regular blood pressure (BP) monitoring is essential, considering the challenges in measurement accuracy among children with intellectual disabilities. Beyond traditional lifestyle modifications, individualized dietary interventions and structured physical activity programs play a fundamental role in HTN prevention and management. Additionally, optimizing sleep quality and addressing comorbidities are essential for improving long-term health outcomes. The updated recommendations emphasize a broader specialist involvement, including endocrinologists, nephrologists, cardiologists, and rehabilitation specialists, to ensure comprehensive care. The integration of these approaches, along with appropriate pharmacological strategies whenever necessary, is crucial for achieving health benefit. This article provides practical guidance for primary care providers, specialists, and caregivers, advocating for a collaborative, patient-centered approach to reducing cardiovascular risks and enhancing the quality of life for children with intellectual disabilities.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1277-1285"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal blood pressure: pathophysiology, measurement and clinical implications. Position paper of the European Society of Hypertension.","authors":"Gianfranco Parati, Martino F Pengo, Alberto Avolio, Michel Azizi, Tomas Lucca Bothe, Michel Burnier, Francesco Paolo Cappuccio, Alejandro De La Sierra, Cristiano Fava, Mariela M Gironacci, Satoshi Hoshide, Kazuomi Kario, Anastasios Kollias, Carolina Lombardi, Giuseppe Maiolino, Simona Maule, Krzysztof Narkiewicz, Takayoshi Ohkubo, Paolo Palatini, Jean Luis Pepin, Pantelis Sarafidis, Aletta Elisabeth Schutte, Alessandro Silvani, George Stergiou, Paolo Verdecchia, Giuseppe Mancia, Grzegorz Bilo","doi":"10.1097/HJH.0000000000004053","DOIUrl":"10.1097/HJH.0000000000004053","url":null,"abstract":"<p><p>Interest in the pathophysiology, measurement, and clinical implications of nocturnal blood pressure (BP) has significantly increased due to its strong association with cardiovascular risk, and its importance was recognized by the 2023 European Society of Hypertension (ESH) guidelines. Nocturnal BP regulation is complex and multifactorial, involving sleep-wake cycle, circadian rhythms, autonomic nervous system, renin-angiotensin-aldosterone system, and renal mechanisms. 24-h ambulatory blood pressure monitoring is currently the reference method for nocturnal BP assessment. Home BP monitoring, with specially designed, validated devices with nocturnal BP measuring function, may also be used, while new cuffless and wearable technologies hold great potential but require further validation. Nocturnal BP phenotypes of clinical interest include nocturnal hypertension, increased nocturnal BP variability and altered day-night BP fluctuations. Among those, isolated nocturnal hypertension may be considered a type of masked hypertension. BP variability has prognostic relevance, as do the day-night BP changes, i.e. the nocturnal BP \"dipping\". Nocturnal hypertension and nondipping are particularly prevalent in individuals with autonomic neuropathies, sleep disorders (e.g., obstructive sleep apnoea), kidney disease, and metabolic or endocrine disorders, and are linked to hypertension mediated organ damage and cardiovascular risk. Therapeutic strategies targeting nocturnal BP remain debated. Chronotherapy (evening dosing of antihypertensives) has shown inconsistent results in clinical trials. Renal denervation and treatment of sleep-related breathing disorders may lower nocturnal BP and improve sleep quality. More research is needed to further clarify pathophysiology, measurement, therapeutic interventions, and overall management of nocturnal hypertension, issues on which this ESH position paper offers an in-depth review.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1296-1318"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential associations between kidney and vascular health biomarkers in young adults stratified by blood pressure status: The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension study.","authors":"Anja Degenaar, Ruan Kruger, Adriaan Jacobs, Marlien Pieters, Catharina Mc Mels","doi":"10.1097/HJH.0000000000004051","DOIUrl":"10.1097/HJH.0000000000004051","url":null,"abstract":"<p><strong>Objective: </strong>Hypertension and kidney disease share common pathophysiological pathways involved in endothelial dysfunction including increased oxidative stress and chronic inflammation. The precise early-stage mechanisms associated with nephron-specific kidney injury remain unclear. We aimed to explore associations of kidney function biomarkers with markers representing these mechanisms in young adults stratified by blood pressure status [according to 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guidelines].</p><p><strong>Methods: </strong>We cross-sectionally analysed 1055 adults. Kidney biomarkers included estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (uACR), alpha-1 microglobulin (uA1M), neutrophil gelatinase-associated lipocalin (uNGAL), uromodulin (uUMOD) and CKD273 classifier. Markers of oxidative stress [gamma-glutamyl transferase (GGT); malondialdehyde (MDA)], inflammation [interleukin 6 (IL-6); C-reactive protein (CRP); fibrinogen] and endothelial function [soluble intercellular adhesion molecule-1; soluble vascular cell adhesion molecule-1 (sVCAM-1); von Willebrand factor antigen (vWF ag ); monocyte chemoattractant protein-1 (MCP-1); plasminogen activator inhibitor-1 activity (PAI-1 act ); urinary nitrate-to-nitrite ratio] were analysed.</p><p><strong>Results: </strong>Individuals in the hypertensive group (mean age 24.8 years; 73.2% men; 39% Black) had higher GGT, CRP, IL-6, MCP-1 and PAI-1 act levels (all P  ≤ 0.024) compared to their normotensive counterparts. In individuals with hypertension, eGFR associated negatively and uNGAL positively with IL-6, while uA1M associated positively with PAI-1 act (all P  ≤ 0.047). In the same group, UMOD associated positively with fibrinogen and CKD273 classifier negatively with MCP-1 (all P  ≤ 0.021). In contrast, eGFR associated positively with MDA and negatively with GGT, CKD273 classifier associated positively with GGT, sVCAM-1 and vWF ag , and uACR associated negatively with CRP (all P  ≤ 0.033) in normotensives.</p><p><strong>Conclusion: </strong>In young adults, mechanisms linked to early nephron-specific kidney injury biomarkers differ according to blood pressure status.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1339-1347"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum adiponectin and risk of incident hypertension: the REGARDS study.","authors":"Aneesh M Singal, Virginia J Howard, Suzanne E Judd, April P Carson, Neil A Zakai, Nels C Olson, Mary Cushman, Timothy B Plante","doi":"10.1097/HJH.0000000000004057","DOIUrl":"10.1097/HJH.0000000000004057","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a cardiovascular disease risk factor disproportionately affecting Black adults. Adiponectin is a cytokine secreted by adipocytes that improves insulin sensitivity, maintains vascular homeostasis, and is inversely associated with adiposity. We sought to determine the risk of incident hypertension by level of adiponectin.</p><p><strong>Methods: </strong>The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 adults from 2003 to 2007. We included REGARDS participants in the Biomarkers as Mediators of Racial Disparities in Risk Factors (BioMedioR) substudy. We estimated the risk ratio for incident hypertension in unadjusted and adjusted models for demographics factors, dietary patterns, measures of adiposity, and SBP.</p><p><strong>Results: </strong>Inverse odds ratio weighting estimated the excess hypertension incidence among Black participants that was explained by adiponectin. Of the 1498 BioMedioR participants, 35% developed incident hypertension in follow-up. White adults had higher baseline adiponectin levels than Black adults. For each 1-SD higher log adiponectin, the risk ratio of hypertension was 0.90 [95% confidence interval (95% CI) 0.84-0.96] in an unadjusted model, 0.92 (0.86-1.00) in a demographic adjusted model, and 0.99 (0.91-1.07) in a fully adjusted model. Lower adiponectin mediated 21-46% of the excess risk of incident hypertension among Black relative to White participants in models adjusting for just demographics and dietary patterns.</p><p><strong>Conclusion: </strong>Among Black and White adults, lower adiponectin was associated with a greater risk of incident hypertension in unadjusted and minimally adjusted models. Future studies into how adiponectin changes in obesity could help to further explain its impact on hypertension risk.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1391-1399"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}