Journal of Hypertension最新文献

{"title":"Sex-specific associations between triglyceride-glucose index and emotional states.","authors":"Abdülmelik Birgün, Mehmet Mustafa Yilmaz, Macit Kalçik","doi":"10.1097/HJH.0000000000004256","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004256","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 6","pages":"1074"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter 'Sex-specific associations between TyG index and emotional states'.","authors":"Mahdieh Niknam, Proushat Shirvani, Leila Cheraghi, Parisa Amiri","doi":"10.1097/HJH.0000000000004289","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004289","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 6","pages":"1074-1076"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiotrophin-1 as a mediator between systolic blood pressure and left ventricular hypertrophy in obesity.","authors":"Chin-Feng Hsuan, Jou-Wei Lin, Thung-Lip Lee, Huai-Wen Liang, Chih-Kun Huang","doi":"10.1097/HJH.0000000000004302","DOIUrl":"10.1097/HJH.0000000000004302","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular hypertrophy (LVH) is prevalent in obesity. Cardiotrophin-1 (CT-1), an interleukin-6 family cytokine implicated in myocardial remodeling, has an unclear role in obesity-associated LVH. This study examined whether CT-1 mediates the association between systolic blood pressure (BP) and left ventricular (LV) mass index in obesity.</p><p><strong>Methods: </strong>Seventy-three adults with body mass index (BMI) ≥35 kg/m 2 underwent clinical evaluation, echocardiography, and serum CT-1 measurement. Mediation analysis was performed using SPSS PROCESS macro (Model 4), with systolic BP as the independent variable, CT-1 as the mediator, and LV mass index as the dependent variable, adjusting for age, sex, and BMI.</p><p><strong>Results: </strong>Mean BMI, systolic BP, LV mass index, and CT-1 level were 42.4 ± 5.7 kg/m 2 , 146 ± 15 mmHg, 50.7 ± 11.8 g/m 2.7 , and 283.07 ± 632.94 pg/ml, respectively. LV mass index correlated with BMI ( r = 0.533, P  < 0.001) and systolic BP ( r  = 0.267, P  = 0.022). CT-1 correlated with systolic BP ( r  = 0.300, P  = 0.010) and LV mass index ( r  = 0.325, P  = 0.005), but not BMI. Mediation analysis showed CT-1 fully mediated the systolic BP-LV mass index association, with a significant indirect effect ( B  = 0.070, 95% CI [0.007, 0.168]) and a non-significant direct effect ( B  = -0.042,   P = 0.600, 95% CI [-0.201, 0.117]).</p><p><strong>Conclusion: </strong>CT-1 mediates the effect of BP on LV mass in severe obesity, suggesting that CT-1 may be a biomarker or therapeutic target in obesity-associated LVH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1056-1061"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial triple-pathway vasorelaxation as an adjunctive strategy in resistant hypertension.","authors":"Paolo Madeddu, Monica Cattaneo, Michael Giuffre, Luke J Laffin","doi":"10.1097/HJH.0000000000004286","DOIUrl":"10.1097/HJH.0000000000004286","url":null,"abstract":"<p><p>Resistant hypertension (RH) affects approximately 10-15% of treated hypertensive adults and up to 50% of individuals with chronic kidney disease (CKD). Defined by persistent elevation of blood pressure despite multidrug therapy, RH reflects inadequate therapeutic control and is associated with accelerated renal function decline, increased cardiovascular morbidity and mortality, and more than US$10 billion in excess annual healthcare costs. Growing evidence indicates that, beyond sodium retention and activation of vasoconstrictor pathways, chronic endothelial dysfunction and maladaptive microvascular remodelling - particularly in CKD-associated RH - are increasingly recognized contributors to disease progression. The vascular endothelium regulates arterial tone through three major vasodilatory systems: nitric oxide (NO), prostacyclin (PGI 2 ), and endothelium-dependent hyperpolarization (EDH). Pharmacologic agents targeting individual pathways have demonstrated short-term vasodilatory effects but have not consistently translated into durable endothelial recovery or microvascular repair in clinical practice. Therapeutic strategies capable of coordinated engagement of all three pathways may therefore be required to modify the vascular abnormalities underlying RH. Human tissue kallikrein-1 (KLK1) and its recombinant analogue, rinvecalinase alfa (DM199), represent a promising approach. In cardiovascular and renal disease models, KLK1 supplementation restores physiological generation of kinin peptides, which, by binding vascular and renal B 2 receptors, stimulate NO, PGI 2 , and EDH signalling pathways, thereby promoting vasorelaxation and natriuresis. Moreover, sustained KLK1 therapy has been associated with improved microvascular integrity and angiogenic signalling through both kinin-dependent and independent mechanisms. Emerging Phase II clinical evidence with DM199 in CKD populations demonstrates blood pressure reduction together with stabilization of renal function and reductions in albuminuria, suggesting potential downstream effects on microvascular structure and function. Importantly, these effects are achieved with a favourable electrolyte and safety profile, supporting investigation in CKD-associated RH where standard therapies often fail. This review integrates contemporary treatment perspectives with mechanistic and clinical evidence supporting KLK1 augmentation as a chronic, endothelial-supportive strategy targeting microvascular remodelling in CKD-associated RH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"918-930"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on transvenous aorticorenal ganglion ablation: a leap towards physiology-guided renal denervation.","authors":"Sushant Saluja","doi":"10.1097/HJH.0000000000004251","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004251","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 6","pages":"948-949"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The theory of hypertensive heart disease and heart failure: revisiting the evidence and pathophysiology.","authors":"Maria Giulia Bellicini","doi":"10.1097/HJH.0000000000004283","DOIUrl":"10.1097/HJH.0000000000004283","url":null,"abstract":"<p><p>Arterial hypertension is a major epidemiological risk factor for left ventricular hypertrophy (LVH) and heart failure (HF). Within this framework, the theory of hypertensive heart disease (HHD) has historically been proposed as the conceptual substrate for HF with preserved ejection fraction (HFpEF). The aim of this state-of-the-art review is to re-examine whether secondary hypertrophic remodelling due to chronic pressure overload represents an intrinsically dysfunctional myocardial state prone to HF, beyond the well recognized role of severe excess afterload as a haemodynamic precipitant of decompensation. This state-of-the-art review critically examines historical, experimental, imaging, histopathological, and clinical trial evidence addressing the relationship between arterial hypertension, afterload, myocardial remodelling, and HF. Across these domains, available evidence does not demonstrate arterial hypertension as a sufficient condition to cause HF, nor does it establish hypertensive myocardial remodelling as an intrinsic cardiomyopathy predisposed to decompensation. Clarifying this distinction has important implications for phenotyping, diagnosis, and interpretation of HF in hypertensive populations.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"911-917"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in blood pressure following transcatheter aortic valve implantation: predictors and association with prognosis.","authors":"Alon Kaplan, Viana Copeland, Ehud Regev, Paul Fefer, David Rott, Amit Segev, Elad Maor, Ehud Grossman","doi":"10.1097/HJH.0000000000004278","DOIUrl":"10.1097/HJH.0000000000004278","url":null,"abstract":"<p><strong>Introduction: </strong>Aortic stenosis significantly contributes to cardiovascular mortality. While hypertension often coexists with aortic stenosis, the long-term effects of transcatheter aortic valve implantation (TAVI) on blood pressure (BP), the predictors of BP changes, and their prognostic significance remain incompletely understood.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 1333 patients who underwent TAVI at Sheba Medical Centre between 2008 and 2023. Changes in SBP and DBP were divided into quintiles (lowest, intermediate, and highest) and assessed for associations with all-cause mortality using Kaplan-Meier survival curves and Cox proportional hazards models, adjusted for clinical and echocardiographic variables. Multinomial logistic regression identified predictors of BP changes.</p><p><strong>Results: </strong>The mean age was 81 years; 50% were men, and 73% had preexisting hypertension. Mean baseline SBP and DBP were 135 and 69 mmHg, respectively. Post-TAVI, SBP increased in 53% of patients, and DBP in 47%. Over a median follow-up of 4.6 years, higher post-TAVI SBP and DBP were independently associated with improved survival, after adjustment for clinical and echocardiographic confounders. Lower baseline left ventricular ejection fraction (LVEF) predicted increased SBP ( P  < 0.001), and female sex predicted increased DBP ( P  < 0.001). Preexisting hypertension did not predict BP changes.</p><p><strong>Conclusion: </strong>Post-TAVI BP elevation is linked to better long-term survival, especially among patients with reduced baseline LVEF, and may reflect a beneficial hemodynamic response rather than comorbidity. Lower baseline LVEF and female sex are independent predictors of this response. These findings support permissive management of BP changes post-TAVI to improve patient outcomes.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"992-998"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive emergency department patients frequently have no existing hypertension diagnosis or antihypertensive medications.","authors":"Grant A Parrelli, Paul I Musey, Diane Kuhn","doi":"10.1097/HJH.0000000000004293","DOIUrl":"10.1097/HJH.0000000000004293","url":null,"abstract":"<p><p>Hypertension is highly prevalent and frequently identified in the emergency department (ED), yet recognition and treatment in this setting remain limited. We conducted a retrospective chart review of 200 randomly selected adults discharged from an urban academic ED in 2024 with at least one blood pressure meeting American Heart Association Stage 1 hypertension criteria. We assessed prior diagnosis, medication use, ED discussion, discharge documentation, and antihypertensive initiation. Although 60.5% of patients had no recorded hypertension diagnosis and 60.5% were not taking antihypertensive medications, only 3.0% had documented discussion of elevated blood pressure, 2.5% received discharge instructions addressing hypertension, and 2.0% were prescribed antihypertensive therapy. In only one case was therapy initiated by the emergency physician without specialist involvement. These findings demonstrate substantial missed opportunities for hypertension recognition and management in the ED and highlight the need for systematic screening, counseling, and treatment pathways.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1071-1073"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wrist-type home blood pressure monitoring device improves usability and preserves sleep quality compared with conventional ambulatory monitoring.","authors":"Cornelia J C Vermeer, Carline J Van den Dries, Monika Hollander, Geert-Jan Geersing, Frans H Rutten","doi":"10.1097/HJH.0000000000004297","DOIUrl":"10.1097/HJH.0000000000004297","url":null,"abstract":"<p><strong>Objective: </strong>To compare usability and impact on sleep quality of a wrist-type home blood pressure monitoring (HBPM) device and a conventional upper-arm 24-h ambulatory blood pressure monitoring (ABPM) device.</p><p><strong>Methods: </strong>In this randomized crossover study, 60 community-dwelling individuals aged 50-80 years from the Reviving Early Detection of cardiovascular disease in the Utrecht Health Project (RED-LRGP) trial underwent wrist-type HBPM (Omron HEM-9601T) and upper-arm ABPM. HBPM included three nocturnal measurements per night (4 h after bedtime, 02 : 00, and 04 : 00) for five nights, with additional morning and evening daytime measurements. ABPM included a single 24-h period with hourly cuff inflations. After each monitoring period, participants completed the system usability scale (SUS) and visual analogue scale (VAS) for sleep quality. Linear mixed-effects models were used to compare usability (SUS) and sleep quality (VAS) between devices.</p><p><strong>Results: </strong>Sixty participants (mean age 58 years, 57% female, 23% hypertensive) completed questionnaires. HBPM showed higher usability (SUS 71.9 versus 52.4; P  < 0.0001) and better sleep quality (VAS 74.6 versus 58.9; P  < 0.0001) than ABPM. With five nightly HBPM measurements, nocturnal hypertension was detected in 27-39% of participants. This was 26% using single-night ABPM measurement. Nondipping patterns occurred in 7-14% with HBPM versus 25% using ABPM. Sixteen participants without obesity, hypertension, or other relevant comorbidities (27%) were classified as HBPM nondippers on ≥1 night.</p><p><strong>Conclusions: </strong>Wrist-type HBPM, combining multinight automated monitoring with high usability and minimal sleep disruption represents a feasible, patient-centered tool for home-based nocturnal BP assessment that has the potential to capture night-to-night BP variability.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1032-1040"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overpowered by uncontrolled hypertension: can we win this war?","authors":"Irakli Todua, Deeb N Salem","doi":"10.1097/HJH.0000000000004307","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004307","url":null,"abstract":"<p><p>Hypertension affects over 1.4 billion adults worldwide. Precise root cause analysis of suboptimal blood pressure control remains critically important for development of most optimal management strategies. We suggest the following evidence-supported steps can be immediately undertaken to improve uncontrolled hypertension treatment outcomes: reduction of the Medicare Quality Payment Program set blood pressure target to widely accepted goal of less than 130/80 mmHg, with the intent of providing additional cardiovascular benefits for senior US citizens; improving hypertension awareness and utilization of ambulatory blood pressure monitoring tools, as well as more frequent screening of uncontrolled patients for treatment noncompliance and/or therapeutic inertia; use of newer pharmaceutical agents in treatment of refractory hypertension, such as recently approved-agent aprocitentan; polypill treatment strategy encouragement, intending to improve poor medication compliance in the areas with challenging socioeconomic conditions; and timely consideration for RDN in multidrug-resistant and/or treatment-noncompliant patients.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 6","pages":"931-937"},"PeriodicalIF":4.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}