Journal of Hypertension最新文献

{"title":"Association between pulse pressure and markers of cognitive function: a systematic review and meta-analysis.","authors":"Olivia Gaunt, Kaavya Venkatesh, Ryan McNally, Phil J Chowienczyk, Marina Cecelja","doi":"10.1097/HJH.0000000000004401","DOIUrl":"10.1097/HJH.0000000000004401","url":null,"abstract":"<p><p>Our aim was to systematically review and meta-analyse evidence on the association between pulse pressure (PP) and cognitive function using PubMed, PsycInfo, Embase and Scopus (inception-July 2025) publication databases. Studies were included if they reported an association between PP and cognitive function and summarized narratively and by performing fixed-effects meta-analysis. The search identified 4171 publications with 43 studies meeting inclusion criteria. Domains assessed included global cognition, memory, language, attention, executive function, processing speed and visuospatial ability. Meta-analysis suggests a positive association between PP and global cognition, and a negative association with memory in both cross-sectional and longitudinal studies with inconsistent findings from narratively summarized studies. Processing speed, executive function and language negatively associated with PP in cross-sectional studies with limited evidence provided by longitudinal studies or narratively summarized studies. There was limited evidence of an association with attention and visuospatial ability.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1692-1707"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxiredoxin-2 inhibits abdominal aortic aneurysm formation by resisting ferroptosis through elimination of reactive oxygen species accumulation in vascular smooth muscle cells.","authors":"Tao Zheng, Qingyun Zhou, Zixuan Wang, Taotao Huang, Yinze Wei","doi":"10.1097/HJH.0000000000004388","DOIUrl":"10.1097/HJH.0000000000004388","url":null,"abstract":"<p><strong>Background: </strong>Abdominal aortic aneurysm (AAA) is defined as the abnormal and progressive dilation of the abdominal aorta, posing a high mortality risk due to its tendency to expand and eventually rupture. Vascular smooth muscle cells (VSMCs), the predominant cell type in the medial layer of the arterial wall, contribute to AAA development through multiple mechanisms, including ferroptosis, apoptosis, and VSMC reprogramming, etc. Here, we investigate the molecular mechanisms by which ferroptosis affects VSMC function and its role in AAA formation.</p><p><strong>Methods: </strong>A single-cell RNA sequencing dataset (GSE164678) was downloaded from the GEO database for re-analysis. Ang II was used to induce C57BL/6J mice to establish an AAA model. After injection of peroxiredoxin-2 (PRDX2)-overexpressing VSMCs, the structural integrity of the abdominal aorta, mitochondrial morphology, as well as the levels of Fe 2+ and lipid peroxides were detected. PRDX2-knockdown VSMCs were constructed and treated with catalase (CAT), followed by the detection of reactive oxygen species (ROS) level, cell proliferation, and angiogenic capacity. Finally, PRDX2-overexpressing VSMCs were treated with H 2 O 2 and Erastin in combination, and the changes in ferroptosis-related indicators were determined.</p><p><strong>Results: </strong>Reanalysis of single-cell RNA sequencing data revealed that PRDX2+ SMCs, a specific subpopulation of smooth muscle cells recruited in AAA, may drive AAA progression through ferroptosis mechanisms. In vivo experiments confirmed that the injection of PRDX2-overexpressing VSMCs alleviated Ang II-induced ferroptosis and inhibited the development of AAA. As a ROS scavenger, PRDX2 effectively suppressed ferroptosis in VSMCs and regulated their proliferation and angiogenic functions.</p><p><strong>Conclusion: </strong>PRDX2 inhibits the formation of AAA by eliminating intracellular ROS accumulation and suppressing ferroptosis in VSMCs, suggesting that targeting PRDX2 to regulate VSMC ferroptosis represents a potential therapeutic strategy for AAA.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1769-1779"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and cardiometabolic impact of mild autonomous cortisol secretion in primary aldosteronism: a systematic review and meta-analysis.","authors":"Naseem Eisa, Mira Khoury","doi":"10.1097/HJH.0000000000004367","DOIUrl":"10.1097/HJH.0000000000004367","url":null,"abstract":"<p><p>Many primary aldosteronism (PA) patients harbor concomitant mild autonomous cortisol secretion (MACS), termed \"Connshing syndrome.\" The prevalence and cardiometabolic impact of this co-secretion have not been quantitatively synthesized. To determine the pooled prevalence of MACS in PA and evaluate its association with cardiovascular (CV) events, type 2 diabetes mellitus (T2DM), and obesity. PubMed, Embase, Cochrane, Web of Science, and Scopus through January 2026. Following PRISMA 2020 and MOOSE guidelines (PROSPERO: CRD420261334965), studies reporting MACS prevalence [post-1 mg dexamethasone suppression test (DST) cortisol ≥1.8 μg/dl] in PA were included. Prevalence was pooled using random-effects models. Odds ratios (ORs) were calculated for cardiometabolic outcomes. Certainty was evaluated using GRADE. Fourteen studies (2356 patients) were included. Pooled MACS prevalence was 26.2% [95% confidence interval (CI): 24.1-28.4; I2 = 24.2%; prediction interval: 21.6-31.4%], consistent across European (27.0%) and East Asian (25.2%) cohorts ( P = 0.62). MACS + PA patients had higher odds of CV events (OR 1.60; 95% CI: 1.07-2.38; P = 0.021) and T2DM (OR 1.37; 95% CI: 1.00-1.86; P = 0.048), but not obesity (OR 1.10; P = 0.411). Sensitivity analyses confirmed robustness. GRADE certainty was moderate for prevalence and low for CV events. Approximately one in four PA patients has MACS, associated with a 60% higher CV event risk. These findings support routine DST screening in PA and have implications for perioperative management and cardiometabolic risk stratification.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1667-1676"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular hypertrophy in hypertension: a systematic review and meta-analysis of echocardiographic studies published from 2011 to 2025.","authors":"Elisa Gherbesi, Andrea Faggiano, Carla Sala, Stefano Carugo, Guido Grassi, Marijana Tadic, Cesare Cuspidi","doi":"10.1097/HJH.0000000000004408","DOIUrl":"10.1097/HJH.0000000000004408","url":null,"abstract":"<p><strong>Aim: </strong>An updated meta-analysis targeting the prevalence of left ventricular hypertrophy (LVH), a cardinal marker of hypertensive heart disease (HHD), over the last 15 years is lacking. Thus, we analyzed the literature in order to provide a comprehensive information on LVH prevalence, as assessed by echocardiography, in the hypertensive setting.</p><p><strong>Methods: </strong>The PubMed, OVID-MEDLINE, and Cochrane Library databases were analyzed to search English-language articles published from 1 January 2011 up to 31 December 2025. Studies were identified by using MeSH terms and crossing the following search items: 'left ventricular hypertrophy', 'left ventricular mass', 'hypertensive heart disease', 'echocardiography', 'hypertension', and 'subclinical cardiac damage'.</p><p><strong>Results: </strong>A total of 51 studies including 74 632 hypertensive patients were considered. Overall, the prevalence of LVH in the pooled cohort, defined according to criteria recommended by echocardiographic guidelines, was 36.6% (95% CI: 33.4-40%). Data provided by 18 studies ( n  = 40 108 patients) showed that the probability of having LVH was lower in men than in women (OR = 0.62, CI: 0.48-0.80, P  < 0.0001). Among patients with LVH (17 studies), the risk of concentric LVH was almost twice as high as eccentric (OR = 1.94, CI: 1.52-2.49, P  < 0.0001).</p><p><strong>Conclusion: </strong>Our meta-analysis suggests that the high contemporary prevalence of LVH reflects the failure of therapeutic strategies worldwide in the prevention and treatment of HHD. From a clinical perspective, these data imply the need for a more aggressive treatment of hypertension and related cardiovascular risk factors leading to LVH, especially in women.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1853-1866"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency department blood pressure elevations frequently occur without documented hypertension diagnosis.","authors":"Diane Kuhn, Paul I Musey, Katherine A Pollard, Grant A Parrelli, Phillip Levy","doi":"10.1097/HJH.0000000000004417","DOIUrl":"10.1097/HJH.0000000000004417","url":null,"abstract":"<p><strong>Background: </strong>High blood pressure readings (HBPRs) are common in emergency department (ED) patients, but the frequency of HBPRs among patients without a documented diagnosis of hypertension (DDxHTN) is unclear.</p><p><strong>Methods: </strong>We performed a retrospective study of discharged ED encounters at a large Midwestern academic ED in 2024. HBPRs were defined as blood pressure ≥130 mmHg systolic or ≥80 mmHg diastolic.</p><p><strong>Results: </strong>Among 66 624 discharged encounters with blood pressure data, 52 461 (78.7%) had at least one HBPR and 38 715 (58.1%) had at least one Stage 2-range HBPR (≥140/90 mmHg). Among patients with Stage 2-range HBPRs, 22 471 (58.0%) lacked DDxHTN. Older age, female sex, Black race, absence of interpreter need, and Medicare or Medicaid coverage were independently associated with DDxHTN.</p><p><strong>Conclusions: </strong>More than half of discharged ED patients with Stage 2-range HBPRs lacked DDxHTN, and many had only a single documented blood pressure. The ED may provide an opportunity for blood pressure reassessment and outpatient referral.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 10","pages":"1893-1895"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Arterial hypertension-attributable mortality in Europe, 2012-2021\".","authors":"Marco Zuin","doi":"10.1097/HJH.0000000000004385","DOIUrl":"10.1097/HJH.0000000000004385","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 10","pages":"1897"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices.","authors":"Paweł Uruski, Justyna Mikuła-Pietrasik, Andrzej Tykarski, Krzysztof Książek","doi":"10.1097/HJH.0000000000004391","DOIUrl":"10.1097/HJH.0000000000004391","url":null,"abstract":"<p><strong>Objectives: </strong>Serum from patients with hypertension (HT) causes endothelial cell (EC) damage, leading to senescence and dysfunctional phenotype. This study investigated whether serum from patients treated with the antihypertensive drugs could normalize EC activity.</p><p><strong>Methods: </strong>This study involved 71 patients with newly diagnosed HT, who were randomly assigned to one of three groups based on the antihypertensive treatment: amlodipine, nebivolol, or perindopril. Serum samples collected before and 6 weeks after treatment were applied to ECs in vitro to assess their angiogenic activity, cellular senescence, mitochondrial metabolism, and oxidative stress.</p><p><strong>Results: </strong>Results showed that exposure of ECs to serum from patients treated for 6 weeks significantly altered EC function, with varying effects among the drugs. Serum from nebivolol-treated patients produced the most consistent benefits, reducing EC proliferation and HIF-1α expression, likely due to lower levels of angiogenic factors such as angiopoietin-1, basic fibroblast growth factor (bFGF), insulin-like growth factor 1 (IGF-1), and vascular endothelial growth factor (VEGF). Additionally, this serum contained reduced levels of pro-inflammatory cytokines (E-selectin, P-selectin, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor α (TNFα)) and lower TGF-β1, which are linked to HT-related EC senescence. Nebivolol treatment decreased senescence biomarkers such as SA-β-Gal, 53BP1, and p16, with SA-β-Gal reduction comparable to that of TGF-β1 neutralizing antibodies. Oxidative stress was reduced, indicated by lower oxidized DNA product levels.</p><p><strong>Conclusions: </strong>Nebivolol was the most effective at reducing the factors, associated with HT induced cellular senescence of endothelium, through reducing TGF-β1.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1780-1790"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure phenotypes and hypertension-associated cardiac damage.","authors":"Maria Randjelovic, Magnus Wijkman, Karin Festin, Lisa Kastbom, David Kylhammar, Fredrik H Nyström, Carl Johan Östgren","doi":"10.1097/HJH.0000000000004406","DOIUrl":"10.1097/HJH.0000000000004406","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to characterize hypertension-associated cardiac damage in the blood pressure (BP) phenotypes sustained normotension (SNT), white coat hypertension (WCHT), masked hypertension (MHT) and sustained hypertension (SHT).</p><p><strong>Methods: </strong>In a population-based study, 4115 individuals were examined with office and home BP measurement, computed tomography, coronary computed tomography angiography and echocardiography. The odds ratios of hypertension-associated cardiac damage in the BP phenotypes were analysed with SNT and SHT as references, respectively, for coronary artery calcium score (CACS) at least 100 and at least 300, Segment Involvement Score (SIS) at least 4, any significant (>50%) coronary stenosis, left ventricular ejection fraction (LVEF) less than 50%, E/e΄ ratio (E/e΄) at least 14, and global longitudinal strain (GLS) greater than -17 (men) or greater than -18 (women).</p><p><strong>Results: </strong>The odds of having hypertension-associated cardiac damage were significantly higher for WCHT than for SNT [LVEF < 50%: OR 1.83 (1.17-2.86), CACS ≥ 100: OR 1.58 (1.19-2.11)], and for SHT than for SNT [LVEF < 50%: OR 2.34 (1.53-3.57), CACS ≥ 100: OR 1.52 (1.14-2.02)]. The odds of having hypertension-associated cardiac damage were also significantly higher for MHT than for SNT (LVEF < 50%: OR 2.68 (1.41-5.10), CACS ≥ 100: OR 2.15 (1.37-3.38) and CACS ≥ 300: OR 2.34 (2.21-4.52)].</p><p><strong>Conclusion: </strong>The prevalence of hypertension-associated cardiac damage was higher in WCHT and in MHT compared to SNT. WCHT and MHT should therefore be considered when assessing cardiovascular risk, and BP should be measured both in the office and at home when diagnosing and monitoring hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 10","pages":"1822-1829"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of annexin A5 against preeclampsia-like phenotypes in mice through the NF-κB/NLRP3 inflammasome pathway.","authors":"Xiaojing Liu, Ziyi Zhang, Ming Jin, Rongwei Ye, Nan Li","doi":"10.1097/HJH.0000000000004246","DOIUrl":"10.1097/HJH.0000000000004246","url":null,"abstract":"<p><strong>Background and objectives: </strong>Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality, yet effective targeted therapies remain limited. This study aimed to investigate the therapeutic potential of annexin A5 (ANX A5) in PE and to elucidate the underlying mechanisms based on metabolomic profiling.</p><p><strong>Methods: </strong>A PE-like mouse model was established by intraperitoneal injection of lipopolysaccharide (LPS, 20 μg/kg/day) from gestational day (GD) 7.5 to 17.5, followed by intravenous administration of ANX A5 (50 μg/kg/day) in the treatment group. In vitro, LPS-stimulated HTR-8/Svneo trophoblast cells were treated with either ANX A5 or NLRP3 inhibitor. Placental metabolite profiling was performed using liquid chromatography-tandem mass spectrometry. Placental morphology and NF-κB/NLRP3 inflammasome markers were evaluated by western blotting and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>ANX A5 administration markedly attenuated high blood pressure, proteinuria, and adverse pregnancy outcomes in PE-like mice. Metabolic alterations associated with ANX A5 were predominantly enriched in the NF-κB/NLRP3 inflammasome pathway. Correspondingly, ANX A5 treatment downregulated the elevated placental expression of NLRP3, caspase-1, and interleukin-1β in PE-like mice. Furthermore, in HTR-8/Svneo cells, ANX A5 effectively suppressed the inflammatory responses by inhibiting the NF-κB/NLRP3 inflammasome signaling pathway, thereby restoring trophoblast migratory capacity.</p><p><strong>Conclusion: </strong>These findings demonstrate that ANX A5 confers significant protection in a PE mouse model, which is mediated through inhibition of the NF-κB/NLRP3 inflammasome pathway and modulation of placental metabolism. This study highlights the potential of ANX A5 as a novel therapeutic strategy for PE.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1761-1768"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative genomic and transcriptomic analysis of hypertension in a Taiwanese population.","authors":"Sheng-Nan Chang, Guan-Wei Lee, Jien-Jiun Chen, Chih-Hsien Wang, Fu-Chun Chiu, Pang-Shuo Huang, Eric Y Chuang, Chia-Ti Tsai","doi":"10.1097/HJH.0000000000004395","DOIUrl":"10.1097/HJH.0000000000004395","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is highly prevalent in Asian populations and represents a major cardiovascular risk factor. However, most genome-wide association studies (GWASs) and transcriptome-wide association studies (TWASs) have focused primarily on Caucasian cohorts. This study aimed to identify genetic loci and gene expression signatures associated with hypertension in an Asian population.</p><p><strong>Methods: </strong>We analyzed 10 739 hypertensive patients and 49 668 controls from the Taiwan Biobank, testing 4 512 191 genome-wide single nucleotide polymorphisms (SNPs). Integrated GWAS, TWAS, and expression quantitative trait locus (eQTL) analyses were conducted to characterize genetic risk. Additionally, a polygenic risk score (PRS) was constructed using a split-sample design to evaluate genetic risk stratification.</p><p><strong>Results: </strong>We identified 14 loci significantly associated with hypertension, including a novel locus at 5p13.1. eQTL analysis linked this locus to DAB2 expression in whole blood. TWAS detected 55 hypertension-associated genes, with 20 (36%) overlapping GWAS loci. Several novel genes outside GWAS loci, including FBXL15, KCNIP2, and CRIP3, were highly significant and implicated in vascular biology and hypertension mechanisms. PRS analysis effectively differentiated hypertension risk, with individuals in the top 10% showing a > 3.5-fold increased risk compared to the bottom 10%.</p><p><strong>Conclusions: </strong>Our findings provide new insights into the genetic and transcriptomic landscape of hypertension in Asians. The identification of novel loci and genes advances understanding of disease biology and may guide precision medicine approaches for risk prediction and therapeutic development.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1812-1821"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}