Journal of Hypertension最新文献

{"title":"Family-based interventions for optimal blood pressure outcomes in adults: a cluster randomised controlled trial in India.","authors":"Panniyammakal Jeemon, Thottathan Athira, Thoniparambil Ravindranathanpillai Lekha, Sunaib Ismail, Sanjay Ganapathi, Sivadasanpillai Harikrishnan","doi":"10.1097/HJH.0000000000004132","DOIUrl":"10.1097/HJH.0000000000004132","url":null,"abstract":"<p><strong>Background and objectives: </strong>Globally, hypertension is a prominent risk factor for disability and death. We assessed the effectiveness of a family-centred strategy for lowering blood pressure in high-risk families.</p><p><strong>Methods: </strong>Engaging families as intervention units, we conducted an open-label, cluster randomised controlled trial (ClinicalTrials.gov NCT02771873). First-degree family members and spouses of those suffering from coronary heart disease (CHD) over the age of 18 were included in the trial. The chosen families were allocated in a ratio of 1 : 1 to the enhanced usual care and intervention arms. The interventions included cardiovascular disease risk screening, systematic lifestyle modifications, facilitating access to primary healthcare services, and ensuring self-care adherence through regular follow-up. We measured the blood pressure at baseline, 12 months, and 24 months using electronic devices. A generalised estimating equation model assessed the between-group population average variation in DBP and SBP levels.</p><p><strong>Results: </strong>The trial involved 1671 participants (women = 1111, mean age = 40.8 years) from 750 families. At the 2-year follow-up, the attrition rate was 3%. The adjusted between-group population average differences in SBP and DBP were -5.23 mmHg, 95% confidence interval (95% CI) -7.01 to -3.47, P  < 0.001, and -2.56 mmHg, 95% CI -3.63 to -1.49, P  < 0.001, respectively. The odds of blood pressure ≥140/90 mmHg at 2-year follow-up was 25% lower in the intervention than the usual care arm (odds ratio 0.75, 95% CI 0.60-0.95, P  = 0.017).</p><p><strong>Conclusion: </strong>Family-centred lifestyle interventions may yield significant public health benefits in maintaining optimal blood pressure in high-risk individuals.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1871-1877"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachial-ankle versus carotid-femoral pulse wave velocity: a systematic review and meta-analysis.","authors":"Konstantinos G Kyriakoulis, Michail Chatzopoulos, Aikaterini Komnianou, Dimitrios Terentes-Printzios, Kyriakos Dimitriadis, Charalambos Vlachopoulos, Athanase D Protogerou, Nikos Pantazis, George S Stergiou, Anastasios Kollias","doi":"10.1097/HJH.0000000000004131","DOIUrl":"10.1097/HJH.0000000000004131","url":null,"abstract":"<p><p>Carotid-femoral pulse wave velocity (cfPWV) is the reference method for measuring large artery stiffness. Automated brachial-ankle pulse wave velocity (baPWV) is an alternative method for assessing medium-to-large artery stiffness. A systematic review/meta-analysis was performed to investigate the relationship of cfPWV and baPWV measurements regarding their difference and association, and their relationship with indices of subclinical target organ damage (TOD) and cardiovascular outcomes. Among 1000 records initially retrieved, 51 were included ( n  = 36 126). Meta-analysis of 46 studies [ n  = 32 426, weighted mean age 61 years, men 49%, BMI 25.1 kg/m 2 , SBP/DBP 129/75 mmHg, hypertension 58%, diabetes 23%, smokers 17%, baPWV 15.82 m/s, cfPWV 9.47 m/s] indicated a pooled baPWV-cfPWV mean difference 5.03 m/s [95% confidence intervals (4.34-5.72)]. Meta-analysis of 23 studies ( n  = 10 880, age 58 years, men 58%, BMI 26.2 kg/m 2 , BP 126/74 mmHg, hypertension 41%, diabetes 16%, smokers 13%) indicated a pooled baPWV vs. cfPWV Pearson correlation coefficient 0.68 (0.61, 0.74). Similar correlations of baPWV/cfPWV with left ventricular mass index, carotid intima-media thickness and urine albumin-to-creatinine ratio were found. Limited data indicated a slightly higher predictive value of cfPWV for cardiovascular outcomes. Sensitivity and multivariable meta-regression analyses indicated significant associations of pooled baPWV-cfPWV mean difference with the distance used for cfPWV calculation and baPWV/cfPWV devices. baPWV and cfPWV are strongly correlated to each other and similarly to subclinical TOD, but baPWV gives higher values. There is considerable heterogeneity among the available studies and standardized design and methodology is needed in future research.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1773-1786"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of olive leaf extracts in controlling blood pressure in hypertensive patients: a double-blind randomized clinical trial.","authors":"Feten Lamti, Imen Trabelsi, Randa Dhaoui, Ekram Hajji, Bilal Ben Amor, Adel Sekma, Lynn Keraani, Marwa Toumia, Lotfi Boukadida, Hajer Yaakoubi, Rahma Jaballah, Arij Bakir, Rym Youssef, Asma Zorgati, Khaoula Bel Haj Ali, Kaouthar Beltaief, Zohra Dridi, Khaldoun Ben Hamda, Walid Jomaa, Nahla Jerbi, Amira Sghaier, Rabie Razgallah, Wahid Bouida, Mohamed Habib Grissa, Jamel Saad, Nourzed Frikha, Ines Khochtali, Hamdi Boubaker, Riadh Boukef, Mohamed Amine Msolli, Semir Nouira","doi":"10.1097/HJH.0000000000004141","DOIUrl":"10.1097/HJH.0000000000004141","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this trial was to assess the effects of olive leaf extract (OLE) on blood pressure (BP) control in patients treated for hypertension.</p><p><strong>Methods: </strong>This is multicenter randomized, double-blind, placebo-controlled trial including 621 participants who were randomly assigned to receive either oral OLE ( n  = 307) or placebo ( n  = 314). The primary outcome was the change in 24-h SBP and DBP from baseline to week-12. Secondary outcomes included the change in BP load (BPL), BP variability (BPV), metabolic parameters, C-reactive protein (CRP), and body weight.</p><p><strong>Results: </strong>OLE significantly reduced 24-h SBP compared to baseline and placebo group [respectively -6.4 mmHg (95% confidence interval, 95% CI -10 to -2.1) and -1.5 mmHg (95% CI -3.9 to 0.51); P  < 0.01]. In OLE group, systolic BPL decreased from 53.9% at baseline to 42.2% at 12-week ( P  = 0.03); in placebo group, it did not change significantly ( P  = 0.55). Diastolic BPL decreased from 30.7 to 21.2% ( P  = 0.03) in OLE group and did not change significantly in placebo group ( P  = 0.12). In OLE group, systolic BPV did not change significantly between baseline and week-12 [+2%; P  = 0.23] while diastolic BPV significantly decreased [-13.3%; P  = 0.04]. In placebo group, BPV did not change significantly at week-12 compared to baseline. OLE was associated with improvement in lipid profile and a significant reduction in blood glucose, triglycerides, CRP, and body weight. No significant adverse events were reported.</p><p><strong>Conclusion: </strong>OLE can decrease 24-h BP, BPL, and diastolic BPV with improvement of lipid profile, systemic inflammation, and body weight in hypertensive patients.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1878-1884"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical role of accurate diagnosis in Liddle's syndrome: a case report and literature review highlighting the importance of genetic testing, a rigorous diagnostic algorithm and early intervention in preventing cardiovascular and renal complications.","authors":"Diego B Ripeau, Paula A Scaglia, Maria E Azcoiti, Maria G Ropelato, Miriam Romo","doi":"10.1097/HJH.0000000000004124","DOIUrl":"10.1097/HJH.0000000000004124","url":null,"abstract":"<p><p>Liddle syndrome is a rare, monogenic, autosomal dominant cause of hypertension linked to mutations in the SCNN1A, SCNN1B, or SCNN1G genes, which are involved in the epithelial sodium channel. This leads to excessive sodium reabsorption, resulting in hypertension, hypokalemia, and low renin and aldosterone levels. Early genetic testing is essential for proper diagnosis and to avoid severe cardiovascular and renal issues. A 16-year-old male with recurrent muscle weakness, hypokalemia, and hypertension was misdiagnosed initially, but genetic testing revealed a mutation in the SCNN1B gene, confirming Liddle syndrome (LS). Treatment with amiloride normalized his potassium levels and stabilized his blood pressure. This case highlights the importance of genetic testing in diagnosing LS, ensuring timely treatment, and preventing complications. Early diagnosis can improve patient outcomes and help identify at-risk family members, underscoring the need for structured diagnostic approaches in cases of suspected LS.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1889-1893"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on the Youth Vascular Consortium's 'Expert consensus documents'.","authors":"J Kennedy Cruickshank","doi":"10.1097/HJH.0000000000004092","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004092","url":null,"abstract":"<p><p>Two major articles in the Journal review childhood arterial function, one the literature, the other methodology complemented by another elsewhere, with a different method focus and presents reference values. Studies of pulse wave velocity (PWV) measured in young children followed into adulthood are just emerging. Like blood pressure (BP), PWV, the index of stiffening, tracks as it rises over time. The carotid arteries are useful indicators, but the vital measurement pathway is from the heart to the descending, distensible aorta's bifurcation. Doppler methods do that well but are too slow to detect real change over time. Tonometry is widely used, requiring two probes for the transit time but is hampered by lack of simultaneous BP recording and few childhood studies calibrating measured or height-adjusted length against magnetic resonance measures. Length errors are compounded in repeat studies by differing probe positions. Cuff-based methods allow 24-h recordings and much wider clinical use; their potential 'imprecision' alienates engineers but are calibrated. Intervention studies as randomized trials in children, adolescents, and young adults can overcome these issues; there are huge preventive opportunities to show the public. Children at school are likely to grasp the notion of how the heart connects to its major blood vessel, what stiffening means, why that is troublesome - and how to keep vessels healthier. Try re-measuring PWV after running, upstairs, or on the flat!</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 11","pages":"1787-1790"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between home blood pressure control status and cardiovascular prognosis in participants with left ventricular hypertrophy: the J-HOP study.","authors":"Takeshi Fujiwara, Satoshi Hoshide, Kazuomi Kario","doi":"10.1097/HJH.0000000000004101","DOIUrl":"10.1097/HJH.0000000000004101","url":null,"abstract":"<p><strong>Objective: </strong>We examined the association between home blood pressure (BP) control status and the cardiovascular disease (CVD) risk associated with left ventricular hypertrophy (LVH) in clinical practice.</p><p><strong>Methods: </strong>J-HOP (Japan Morning Surge-Home BP) Study participants underwent home BP monitoring in the morning and evening for a 14-day period and echocardiography at baseline. Controlled home BP was defined as morning SBP less than 135 mmHg and morning DBP less than 85 mmHg. LVH was defined as LV mass index greater than 115 g/m 2 in men and greater than 95 g/m 2 in women.</p><p><strong>Results: </strong>Among 1823 participants [mean [SD] age: 65.1 [11.6] years; 48.6% men; 82% on antihypertensive medications], 1112 (61%) showed uncontrolled BP, and 662 (36.3%) participants had LVH (233 men, 429 women). Over a median 6.8-year follow-up (11 985 person-years), 140 total CVD events occurred. In the uncontrolled BP group ( n  = 440), participants with LVH had higher incident rates of total CVD events compared to those without LVH, but this was not the case in the controlled BP group. Cox models suggested that LVH was associated with increased risk of total CVD events in the uncontrolled BP group [adjusted hazard ratio (aHR) 1.80, 95% confidence interval (CI) 1.17-2.75], and again, this was not the case in the controlled BP group (aHR 1.32, 95% CI 0.70-2.50).</p><p><strong>Conclusion: </strong>The CVD risk associated with LVH differed depending on the morning home BP control status. The assessment of LVH is important to optimize risk stratification of CVD in clinical practice, especially in participants with uncontrolled home BP.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1793-1801"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant hypertension as a presentation of complement-mediated thrombotic microangiopathy: case series report.","authors":"Xiaohui Zhang, Wenhua Bi, Chengjun Ma, Kun Li, Yanxia Gao","doi":"10.1097/HJH.0000000000004116","DOIUrl":"10.1097/HJH.0000000000004116","url":null,"abstract":"<p><p>Complement-mediated thrombotic microangiopathy (TMA) presenting as malignant hypertension (mHTN) is frequently misdiagnosed as mHTN-associated TMA, particularly when their clinical presentations overlap. The diagnostic challenge is further compounded when patients have normal serum levels of complement factor H (CFH) and test negative for anti-CFH. We presented two patients of complement-mediated TMA exhibiting clinical features consistent with mHTN-associated TMA, yet their renal function did not improve following the achievement of target blood pressure (BP) levels. Notably, both patients demonstrated elevated serum soluble C5b-9 levels. Based on these findings, we hypothesized the presence of complement-mediated TMA and initiated treatment with eculizumab. Consequently, one patient was successfully weaned off dialysis, and the other experienced substantial improvement in renal function, highlighting that in patients with mHTN-associated TMA where antihypertensive treatment fails to ameliorate renal function, consideration should be given to the possibility of complement-mediated TMA.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1885-1888"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond resting measurements: exercise pulse pressure and its association with heart failure hospitalization.","authors":"Wei-Ming Huang, Liang-Yin Lin, Chih-Hsueh Tseng, Hao-Chih Chang, Chi-Jung Huang, Wen-Chung Yu, Hao-Min Cheng, Chern-En Chiang, Chen-Huan Chen, Shih-Hsien Sung","doi":"10.1097/HJH.0000000000004105","DOIUrl":"10.1097/HJH.0000000000004105","url":null,"abstract":"<p><strong>Background: </strong>Pulse pressure (PP), the difference between SBP and DBP, is a known predictor of heart failure. While high resting PP has been linked to increased heart failure risk, the implications of exercise-induced PP changes remain less understood. This study investigates the contrasting roles of exercise PP in predicting hospitalization for heart failure (hHF).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of adults referred for treadmill exercise testing between 2003 and 2012. ΔMaximal blood pressure (BP) referred to the BP change from rest to peak exercise. Cox proportional hazards models adjusted for demographic and clinical variables were used to assess the predictive value of PP changes for hHF.</p><p><strong>Results: </strong>Among 15 249 participants, 117 (0.7%) were hospitalized for HF over a median follow-up of 112 months. Higher resting PP was significantly associated with an increased risk of hHF, whereas increased exercise PP was inversely related to hHF risk independently (adjusted hazard ratio: 0.988, 95% confidence interval: 0.977-0.998, P  < 0.001).</p><p><strong>Conclusion: </strong>Resting PP and Exercise PP exhibit opposite effects on the risk of heart failure hospitalization. These findings suggest the importance of considering both resting and exercise-induced PP changes in the assessment and management of heart failure risk.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1816-1822"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring early vascular aging in youth: an expert consensus document from the Youth Vascular Consortium.","authors":"Jeanne Hersant, Ruan Kruger, Elisabetta Bianchini, Karsten Königstein, Manish D Sinha, Erzsébet V Hidvégi, Vimarsha Kodithuwakku, José Geraldo Mill, Alejandro Diaz, Yanina Zócalo, Daniel Bia, David Celermajer, Henner Hanssen, Madeleine Johansson, Giacomo Pucci, Mieczysław Litwin, Keeron Stone, Christopher J A Pugh, Lee Stoner, Elaine M Urbina, Rosa Maria Bruno, Peter M Nilsson, Rachel E Climie","doi":"10.1097/HJH.0000000000004039","DOIUrl":"10.1097/HJH.0000000000004039","url":null,"abstract":"<p><p>Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with these biomarkers in youth, a standardized approach for clinical evaluation of EVA remains elusive, leaving pertinent gaps in understanding the optimal methodology. This article, resulting from international consensus efforts from the Youth Vascular Consortium, aims to provide an updated overview of methods available to measure EVA in youth and to discuss challenges in translating these methods into clinical practice.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1733-1742"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroinflammation and hypertensive cardiac hypertrophy: mechanisms, pathways, and therapeutic perspectives.","authors":"Shijun Li, Beibei Wang, Jiaojiao Xing, Xiaoying Li","doi":"10.1097/HJH.0000000000004108","DOIUrl":"10.1097/HJH.0000000000004108","url":null,"abstract":"<p><p>Hypertensive cardiac hypertrophy is a major pathological consequence of chronic hypertension, leading to heart failure and increased cardiovascular morbidity. Emerging evidence highlights the critical role of neuroinflammation in the development and progression of hypertensive cardiac hypertrophy. This review provides a comprehensive overview of the interplay between neuroinflammation and hypertensive cardiac hypertrophy, focusing on the roles of the sympathetic nervous system (SNS), immune activation, and central nervous system (CNS) dysregulation. We also explore the molecular mechanisms underlying neuroinflammation-induced cardiac remodeling and discuss potential therapeutic strategies targeting neuroinflammatory pathways. By integrating recent preclinical and clinical findings, this review aims to shed light on novel approaches to prevent or reverse hypertensive cardiac hypertrophy through modulation of neuroinflammation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1750-1763"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}