Journal of Hypertension最新文献

{"title":"Low flow state masks true arterial stiffness on pulse wave analysis in patients with severe aortic stenosis.","authors":"Ning Song, Sara L Hungerford, Mayooran Namasivayam, Andrew Jabbour, Christopher S Hayward, David W M Muller, Audrey I Adji","doi":"10.1097/HJH.0000000000004064","DOIUrl":"10.1097/HJH.0000000000004064","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis is a common valvular disorder that shares pathophysiological principles with age-associated elevated arterial stiffness. Flow attenuation from valvular obstruction in aortic stenosis may lead to under-estimation of true arterial stiffness, particularly in aortic stenosis patients with reduced stroke volume.</p><p><strong>Methods: </strong>Severe aortic stenosis patients were divided into high mean transvalvular gradient (HG, ≥40 mmHg) and low mean transvalvular gradient (LG, <40 mmHg) and compared with elderly controls without aortic stenosis. Aortic pressures were obtained from radial arterial tonometry calibrated to brachial cuff pressures simultaneously with aortic flows acquired via cardiac magnetic resonance phase contrast imaging. Pulse wave analysis was performed and pulsatile arterial load indices calculated using frequency domain analysis.</p><p><strong>Results: </strong>We analysed 58 patients, with 21, 16 and 21 patients in the high gradient, low gradient and control groups, respectively. Aortic stenosis patients had higher augmentation indices (high gradient 40 ± 8%; low gradient 38 ± 7%; control 32 ± 9%, P  < 0.01) despite lower mean arterial pressure (high gradient 91 ± 22 mmHg; low gradient 94 ± 23 mmHg; control 109 ± 17 mmHg, P  =0.02). Cardiac output, systemic vascular resistance and aortic characteristic impedance were comparable. The high gradient group had a significantly higher stroke volume index (high gradient 39 ± 8 ml/m 2 ; low gradient 33 ± 7 ml/m 2 ; control 34 ± 7 ml/m 2 , P  = 0.02), but stroke volume index was positive correlated with augmentation index only in the low gradient group ( R  = 0.57, P  = 0.02).</p><p><strong>Conclusion: </strong>In patients with low gradient aortic stenosis, smaller stroke volume index is associated with lower measured arterial stiffness by augmentation index on pulse wave analysis, suggesting that ventriculo-valvulo-arterial uncoupling due to elevated arterial stiffness may be more pronouncedly under-estimated in patients low-flow, low-gradient aortic stenosis.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1407-1415"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swimming-based training ameliorates cardiac dysfunction and oxidative stress in chronically stressed rats.","authors":"Carlos H O Reis, Leonardo Dos Santos, Elis A Morra, Divanei A Zaniqueli, Ana Paula Lima-Leopoldo, Julien S Baker, Andre S Leopoldo, Danilo S Bocalini","doi":"10.1097/HJH.0000000000004047","DOIUrl":"10.1097/HJH.0000000000004047","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to evaluate the influence of swimming training on cardiac structure and function, and oxidative stress induced by the rat model of chronic restraint stress.</p><p><strong>Methods: </strong>Young Wistar-UFES rats (n:40) were distributed in four groups: Control, Trained, Stressed, and Stressed and Trained. The training program consisted of 60 min per day, five times a week for 12 weeks, without additional load. The restraint stress was applied using an opaque PVC cylinder for 1 h per day, 5 days a week, for 12 weeks. Physical capacity, blood pressure, ventricular performance via echocardiogram, histological evaluations, and oxidative stress were assessed.</p><p><strong>Results: </strong>After 12 weeks, only the trained groups improved physical capacity. Corticosterone levels (nmol/l) were higher than in the Trained group (174 ± 9) compared to Control (141 ± 8). Swimming training does not prevent the increase (Stressed and trained: 231 ± 17) but mitigate the effect of restraint stress on the corticosterone circulation (Stressed: 335 ± 24). SBP (mmHg) was similar in Trained (138 ± 14) and Control (135 ± 22). Chronic stress significantly increased SBP (180 ± 13), while swimming training prevented partially this increase (Stressed and Trained: 164 ± 16). Regarding ventricular performance, the A wave (mm/s) was lower in the Stressed group (268 ± 36) compared to Control (342 ± 63), Trained (355 ± 74), and Stressed and Trained (360 ± 80), and the E/A ratio was higher in the Stressed group (2.96 ± 0.70) compared to Control (1.66 ± 0.28), Trained (1.55 ± 0.30), and Stressed and Trained (1.75 ± 0.33). The values of DT, +dT/dtmax, and -dT/dtmax Trained group was high than Control, Stressed, and Stressed and Trained groups. For nuclear volume (μm3), no differences were observed between the Control (144 ± 7) and Trained (146 ± 7) groups, and both were smaller than the Stressed (175 ± 10) and Stressed and Trained (161 ± 2) groups, which differed from each other. Malondialdehyde (MDA, in μmol/l/mg) increased in the Stressed group (0.74 ± 0.07) beyond control levels (Control: 0.49 ± 0.09). This increase in MDA levels was prevented by swimming training (Stressed and trained: 0.43 ± 0.12). Oxidized proteins (μmol/l) also increased with restraint stress (Stressed: 1.4 ± 0.4 vs. Control: 0.76 ± 0.10, and Trained: 0.72 ± 0.04), but this increase was prevented by swimming training (Stressed and Trained: 0.69 ± 0.11).</p><p><strong>Conclusion: </strong>Restraint stress caused a significant increase in SBP, impairments in diastolic function, increase in nuclear volume, and oxidative stress. Swimming training in turn prevented these stress-evoked effects.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1381-1390"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing prediction models for electrolyte abnormalities in patients indicated for antihypertensive therapy: evidence-based treatment and monitoring recommendations.","authors":"Ariel Wang, Constantinos Koshiaris, Lucinda Archer, Richard D Riley, Kym I E Snell, Richard Stevens, Amitava Banerjee, Juliet A Usher-Smith, Subhashisa Swain, Andrew Clegg, Christopher E Clark, Rupert A Payne, F D Richard Hobbs, Richard J McManus, James P Sheppard","doi":"10.1097/HJH.0000000000004032","DOIUrl":"10.1097/HJH.0000000000004032","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence from clinical trials suggests that antihypertensive treatment is associated with an increased risk of common electrolyte abnormalities. We aimed to develop and validate two clinical prediction models to estimate the risk of hyperkalaemia and hyponatraemia, respectively, to facilitate targeted treatment and monitoring strategies for individuals indicated for antihypertensive therapy.</p><p><strong>Design and methods: </strong>Participants aged at least 40 years, registered to an English primary care practice within the Clinical Practice Research Datalink (CPRD), with a systolic blood pressure reading between 130 and 179 mmHg were included the study. The primary outcomes were first hyperkalaemia or hyponatraemia event recorded in primary or secondary care. Model development used a Fine-Gray approach with death from other causes as competing event. Model performance was assessed using C-statistic, D-statistic, and Observed/Expected (O/E) ratio upon external validation.</p><p><strong>Results: </strong>The development cohort included 1 773 224 patients (mean age 59 years, median follow-up 6 years). The hyperkalaemia model contained 23 predictors and the hyponatraemia model contained 29 predictors, with all antihypertensive medications associated with the outcomes. Upon external validation in a cohort of 3 805 366 patients, both models calibrated well (O/E ratio: hyperkalaemia 1.16, 95% CI 1.13-1.19; hyponatraemia 1.00, 95% CI 0.98-1.02) and showed good discrimination at 10 years (C-statistic: 0.69, 95% CI 0.69-0.69; 0.80, 95% CI 0.80-0.80, respectively).</p><p><strong>Conclusion: </strong>Current clinical guidelines recommend monitoring serum electrolytes after initiating antihypertensive treatment. These clinical prediction models predicted individuals' risk of electrolyte abnormalities associated with antihypertensive treatment and could be used to target closer monitoring for individuals at a higher risk, where resources are limited.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1348-1359"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure management in clinically complex scenarios: new horizons for a tailored approach.","authors":"Maria Concetta Pastore, Riccardo Liga, Enrico Emilio Diviggiano, Carlo Vitale, Alessandro Parlato, Francesca Amati, Flavio D'ascenzi, Egidio Imbalzano, Andrea Rinaldi, Pietro Scicchitano, Anna Vittoria Mattioli, Marco Matteo Ciccone, Roberto Pedrinelli, Matteo Cameli","doi":"10.1097/HJH.0000000000004025","DOIUrl":"10.1097/HJH.0000000000004025","url":null,"abstract":"<p><p>Arterial hypertension is a major preventable cardiovascular risk factor, which is estimated to be responsible of around 25% of heart attacks and 40% of cardiovascular deaths in Europe. As the prevalence of arterial hypertension is continuously growing in the general population, it is estimated that by 2025 up to 60% of the adult western population will suffer from high blood pressure (BP), making arterial hypertension a timely topic for scientific research. The management of BP in specific conditions such as heart failure, kidney diseases or paediatric patients could be challenging. In the last years, new drugs have been introduced, changing the landscape of heart failure treatment, while possibly having a significant impact on BP regulation and kidney function. Similarly, while resistant hypertension may represent a true issue for clinicians and patients, novel therapeutic approaches are now available. In this regard, while for instance renal artery denervation has been introduced as an innovative therapy for patients with resistant hypertension, it has possibly shown consistent benefits also in patients with heart failure at large, whereby it could significantly reduce sympathetic nervous activation. This review focuses on new perspectives for the management of BP in these specific populations in order to provide practical hints for a tailored approach for clinically complex and/or resistant patients.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1267-1276"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex disparities in awareness, treatment, and control of hypertension in Peru.","authors":"Carlos Diaz-Arocutipa, Rafael Salguero-Bodes, Elena Puerto, Roberto Martín-Asenjo, Lourdes Vicent","doi":"10.1097/HJH.0000000000004072","DOIUrl":"10.1097/HJH.0000000000004072","url":null,"abstract":"<p><strong>Objective: </strong>Understanding sex differences in the hypertension treatment cascade is essential, particularly in developing countries where such data are limited. This study aimed to evaluate sex differences in hypertension awareness, treatment, and control in Peru.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from the 2023 Peruvian Demographic and Health Survey, a nationally representative survey using a stratified, two-stage cluster sampling design. We included individuals aged at least 15 years with complete and valid blood pressure data. Hypertension was defined based on self-reports and blood pressure measurements. Binary logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI), and all analyses were weighted to account for the survey's complex design.</p><p><strong>Results: </strong>In total, 36 075 individuals were included (mean age 41 years; 51.9% women). The prevalence of hypertension was lower in women than in men [17.8 vs. 20.9%; odds ratio (OR) 0.66, 95% CI 0.59-0.75]. However, women exhibited significantly higher odds of hypertension awareness (70.4 vs. 41.6%; OR 3.41, 95% CI 2.70-4.30), treatment (42.8 vs. 25.3%; OR 2.05, 95% CI 1.59-2.64), and control (45.7 vs. 21.3%; OR 3.35, 95% CI 2.68- 4.18) compared to men.</p><p><strong>Conclusion: </strong>In Peru, notable sex differences exist in the hypertension treatment cascade, with women more likely than men to be aware of, treated for, and have controlled hypertension. These findings highlight the need for sex-specific strategies to improve hypertension management outcomes.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1442-1449"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure-lowering efficacy of Sacubitril/Allisartan versus Olmesartan in Chinese hypertensive patients with a nondipping blood pressure pattern.","authors":"Wei Zhang, Jie Yan, Jin Zhang, Qian Ge, Xiao-Hong Lu, Shao-Xing Chen, Wen-Jie Xu, Jing-Chao Sun, Jin-Feng Li, Zi-Chen Liu, Qiang Wang, Xiang-Nan Zhou, Yan Li, Ji-Guang Wang","doi":"10.1097/HJH.0000000000004065","DOIUrl":"10.1097/HJH.0000000000004065","url":null,"abstract":"<p><strong>Background: </strong>Abnormal nocturnal blood pressure dipping profile is an important cardiovascular risk factor in patients with hypertension. This analysis aimed to investigate the effects of Sacubitril/Allisartan on blood pressure in Chinese patients with mild to moderate hypertension and a nighttime nondipping pattern.</p><p><strong>Methods: </strong>We performed analysis of data from a randomized clinical trial that compared the blood pressure-lowering effect at 12 weeks of treatment with Sacubitril/Allisartan (240 or 480 mg/day) and Olmesartan (20 mg/day). Nighttime nondipping pattern was defined as mean nighttime (10 p.m. to 6 a.m.) ambulatory blood pressure fall of less than 10% versus daytime (6 a.m. to 10 p.m.) ambulatory blood pressure. The outcome measures included clinical and 24-h, daytime, and nighttime ambulatory blood pressure.</p><p><strong>Results: </strong>Of the 1197 randomized patients of the trial, 497 (41.5%) patients had a nighttime nondipping pattern and were included in this analysis. At 12 weeks, the least square mean (±standard error) changes from baseline in 24-h mean ambulatory SBP/DBP (maSBP/maDBP) in the Sacubitril/Allisartan 240 and 480 mg/day groups were -10.3 ± 1.1/-5.3 ± 0.6 and -13.7 ± 1.1/-6.7 ± 0.6 mmHg, respectively. The reductions in nighttime maSBP were significantly greater with both doses of Sacubitril/Allisartan compared with Olmesartan 20 mg [-12.7 ± 1.2/6.3 ± 0.7 mmHg, with a difference of -3.8 (-7.2 to -0.4) mmHg, P  = 0.029 for Sacubitril/Allisartan 240 mg and -7.5 (-10.9 to -4.1) mmHg, P  < 0.001 for Sacubitril/Allisartan 480 mg]. The 24-h mean ambulatory blood pressure and nighttime maSBP reductions in nondipper patients tended to be dose-dependent for Sacubitril/Allisartan. At 12 weeks of treatment, the prevalence of dippers was significantly ( P  ≤ 0.019) higher in the Sacubitril/Allisartan 240 and 480 mg groups than in the Olmesartan 20 mg group for both SBP (46.9 and 47.9 versus 33.7%) and DBP (42.0 and 40.2 versus 26.5%).</p><p><strong>Conclusion: </strong>Sacubitril/Allisartan is particularly effective in reducing nighttime blood pressure and in reversing the nondipping to dipping nighttime blood pressure pattern.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1416-1422"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiorespiratory fitness and pediatric primary hypertension: a case-control study in China.","authors":"Tingjuan Lin, Wenqing Jiang, Yao Lin, Mingming Zhang, Tong Zheng, He Jiang, Baosheng Liang, Yan Liu, Yu Chen, Qin Zhang, Lin Shi","doi":"10.1097/HJH.0000000000004036","DOIUrl":"10.1097/HJH.0000000000004036","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the association between cardiorespiratory fitness (CRF) and the risk of primary hypertension in children and adolescents, and to explore the relationship between CRF and hemodynamic parameters.</p><p><strong>Methods: </strong>In this single-center case-control study, 972 participants aged 10-17 years (352 hypertension cases, 620 controls) were included. CRF was quantified as peak oxygen uptake (VO 2peak ) using a validated equation derived from treadmill tests. Logistic regression models, restricted cubic splines, and subgroup analyses were employed to assess CRF-hypertension associations, adjusted for age, sex, height, and overweight/obesity. Multivariate linear regression evaluated correlations between CRF and blood pressure or heart rate parameters.</p><p><strong>Results: </strong>After adjustment, each 5 ml/kg/min increment in CRF was associated with a 30% reduction in hypertension risk [odds ratio (OR) 0.70, 95% confidence interval (95% CI) 0.63-0.78, P  < 0.001]. Participants with CRF less than 44.7 ml/kg/min exhibited a 3.35-fold higher hypertension risk than those with CRF at least 44.7 ml/kg/min (OR 3.35, 95% CI 2.21-5.16, P  < 0.001). Subgroup analyses confirmed consistency across age, sex, height, and BMI status ( P for interaction > 0.05). Notably, overweight/obese individuals showed a 35% risk reduction per 5 ml/kg/min CRF improvement (OR 0.65, 95% CI 0.57-0.74). CRF was inversely correlated with systolic, diastolic, and mean arterial blood pressure, resting and peak heart rate, peak SBP/DBP, and rate-pressure product (all P  < 0.05).</p><p><strong>Conclusion: </strong>Higher CRF is independently associated with reduced primary hypertension risk in children and adolescents, highlighting its role as a modifiable protective factor, particularly among overweight/obese youth. These findings support CRF-enhancing interventions as a preventive strategy against pediatric hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1360-1366"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality risks in different subtypes of white-coat hypertension: implications for the diagnosis of white-coat hypertension.","authors":"Alejandro de la Sierra, Luis M Ruilope, Natalie Staplin, George S Stergiou, Ernest Vinyoles, Bryan Williams","doi":"10.1097/HJH.0000000000004076","DOIUrl":"10.1097/HJH.0000000000004076","url":null,"abstract":"<p><strong>Background: </strong>The risk associated with white-coat hypertension is controversial. We evaluated mortality risks in white-coat hypertension subtypes defined according to the circadian pattern of blood pressure (BP) elevation over 24 h.</p><p><strong>Methods: </strong>In 44 119 patients with elevated office BP, white-coat hypertension subtypes were defined as normal BP in all circadian periods (day, night, and 24-h, 12 192 patients), normal 24-h, with nocturnal BP elevation (4368), and normal daytime, with 24-h BP elevation (3525). Associations of each subtype with all-cause and cardiovascular mortality were estimated by Cox-regression models, adjusted for clinical confounders, compared to a reference group of 7690 patients with normal both office and ambulatory (all periods) BP.</p><p><strong>Results: </strong>Compared to the reference group, white-coat hypertension defined by normal BP in all circadian periods was not associated with an increased risk of all-cause [hazard ratio, 0.94 [95% confidence interval, 95% CI,0.85-1.03]) or cardiovascular death (hazard ratio, 0.91 [95% CI,0.76-1.08]). In contrast, white-coat hypertension defined by normal daytime, but with elevated 24-h BP, was associated with increased risks of all-cause (hazard ratio, 1.27 [95% CI,1.13-1.42]) and cardiovascular death (hazard ratio, 1.37 [95% CI,1.12-1.68]). The group of white-coat hypertension defined by normal 24-h BP, but with nocturnal BP elevation had increased crude rates of death, but risks were not significantly increased after adjusting for confounders.</p><p><strong>Conclusion: </strong>White-coat hypertension is a heterogeneous condition in terms of associated risk of death. A definition based only on a normal daytime BP may mask a significant group of patients with increased 24-h or night BP, who exhibit an increased risk of mortality.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1450-1456"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms for changes in blood pressure after nonsevere COVID-19.","authors":"Sikandar Khan, Arsh Issany, Aayush Visaria","doi":"10.1097/HJH.0000000000004058","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004058","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 8","pages":"1457-1459"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor IX and incident hypertension in Black and White adults: the REasons for Geographic and Racial Differences in Stroke cohort.","authors":"Eric G Stoutenburg, Maria C Bravo, Virginia J Howard, Suzanne E Judd, D Leann Long, Timothy B Plante","doi":"10.1097/HJH.0000000000004045","DOIUrl":"10.1097/HJH.0000000000004045","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a cardiovascular disease risk factor disproportionately affecting Black adults. Certain biomarkers of thrombosis and inflammation are associated with a greater risk of hypertension. Factor IX is a marker of thrombosis; Black adults have higher levels than others. Whether factor IX correlates with incident hypertension risk or explains some of the disproportionate burden faced by Black adults, is not known.</p><p><strong>Methods: </strong>REasons for Geographic and Racial Differences in Stroke (REGARDS) recruited 30 239 Black and White adults from the contiguous US in 2003-2007 (Visit 1) and had repeat assessment in 2013-2016 (Visit 2). Factor IX was measured in Visit 1 samples in a sex-race stratified sample of 4400 participants that attended both visits. Modified Poisson regression estimated adjusted risk ratios (RR) for incident hypertension at Visit 2 by factor IX tertiles. Inverse odds ratio weighting estimated the proportion of the excess burden of incident hypertension in Black adults due to factor IX levels.</p><p><strong>Results: </strong>Among 1824 participants (55% female and 24% Black race), 36% developed hypertension. The fully adjusted RR for the third vs. first tertile was 1.21; 95% confidence interval (CI) 1.03-1.43, and there was a significant linear trend across tertiles ( P  < 0.001). Factor IX did not mediate excess hypertension risk among Black adults in adjusted models.</p><p><strong>Conclusions: </strong>In this prospective study of Black and White adults without prevalent hypertension, higher factor IX was associated with a greater risk of incident hypertension. This risk may relate to adverse thromboinflammation among persons in the 2nd and 3rd tertiles of factor IX.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1373-1380"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}