Journal of Hypertension最新文献_第2页

Response to Wuopio et al.: Concerns regarding the use of inappropriate statistical methods and unreliable references. 对Wuopio等人的回应：对使用不恰当的统计方法和不可靠的参考文献的担忧。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.1097/HJH.0000000000004049

Jing Song, Changqiong Wang, Sonia Pombo-Rodrigues, Graham A MacGregor, Norm R C Campbell, Feng J He

引用次数: 0

Limitations of constant sodium estimates: a response to Song et al. 恒定钠估计的局限性：对Song等人的回应。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.1097/HJH.0000000000004044

Jonas Wuopio, Linda S Johnson, Andrew Mente, Johan Ärnlöv

引用次数: 0

Controversies in hypertension therapy: bedtime dosing or daytime dosing? 高血压治疗的争议：睡前给药还是白天给药？

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1097/HJH.0000000000004035

Haojiang Li, Ru Sun, Yahui Li, Xindi Yue, Li Ni, Ling Zhou, Chunxia Zhao

引用次数: 0

The European Society of Cardiology got it wrong: their target systolic blood pressure in chronic kidney disease patients is not low enough! 欧洲心脏病学会错了：慢性肾病患者的目标收缩压不够低！

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.1097/HJH.0000000000004048

Robert S Brown

引用次数: 0

Effect of telemonitoring and home blood pressure monitoring on blood pressure reduction in hypertensive adults: a network meta-analysis. 远程监测和家庭血压监测对高血压成人血压降低的影响：网络荟萃分析。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-03-27 DOI: 10.1097/HJH.0000000000004008

Shubhima Grover, Hara Prasad Mishra, Rachna Gupta, Lalit K Gupta

{"title":"Effect of telemonitoring and home blood pressure monitoring on blood pressure reduction in hypertensive adults: a network meta-analysis.","authors":"Shubhima Grover, Hara Prasad Mishra, Rachna Gupta, Lalit K Gupta","doi":"10.1097/HJH.0000000000004008","DOIUrl":"10.1097/HJH.0000000000004008","url":null,"abstract":"Introduction: Telemonitoring and home blood pressure monitoring (HBPM) are becoming popular approaches for managing hypertension. They are believed to improve patient compliance as compared to the usual care monitoring. This network meta-analysis was undertaken to compare blood pressure (BP) reduction following telemonitoring, HBPM and usual care BP monitoring approaches.Methods: PubMed and clinicaltrial.gov were searched till 15 May 2024 for randomized controlled trials (RCTs) comparing telemonitoring, HBPM and usual care monitoring for reduction in BP and the postintervention BP in hypertensive adults.Results: A network meta-analysis with 24 RCTs was performed using MetaInsight. Telemonitoring produced a significantly greater reduction in the systolic blood pressure (SBP) (-3.69 mmHg [95% CI -5.82; -1.57, P < 0.001]) and the diastolic blood pressure (DBP) (-1.82 mmHg [95% CI -2.98 to -0.67, P < 0.001]) as compared to the usual care monitoring. Home BP monitoring also produced a greater lowering of SBP (-2.73 mmHg [95% CI -5.69 to 0.22, P = 0.069]) and DBP (-2.09 mm Hg [95% CI -3.66 to -0.52, P < 0.001]) than usual care, with a significant reduction in the DBP alone. The postintervention SBP and DBP were also lower in the telemonitoring and the HBPM groups than the usual care group. However, there was no significant difference between the SBP and the DBP reductions in the telemonitoring and the HBPM groups.Conclusion: Telemonitoring and HBPM may be more useful in controlling BP as compared to usual care management alone. However, more direct studies comparing telemonitoring with HBPM are needed in the future.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1091-1098"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the relationship between short-term blood pressure variability and glycation profile in young and middle-aged nondiabetic hypertensive individuals. 评估中青年非糖尿病性高血压患者短期血压变异性与糖化特征之间的关系。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/HJH.0000000000004029

Nestor Vazquez-Agra, Lucia Barrera-Lopez, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras

{"title":"Assessing the relationship between short-term blood pressure variability and glycation profile in young and middle-aged nondiabetic hypertensive individuals.","authors":"Nestor Vazquez-Agra, Lucia Barrera-Lopez, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras","doi":"10.1097/HJH.0000000000004029","DOIUrl":"10.1097/HJH.0000000000004029","url":null,"abstract":"Introduction: Elevated short-term blood pressure (BP) variability (BPV) has been associated with a poorer cardiovascular prognosis. The glycation profile is related to BPV in diabetic and prediabetic individuals. However, little is known about the relationship between glycation levels and BPV in hypertensive patients with optimal glycemic control.Objectives: This observational study aimed to elucidate the relationship between glycated hemoglobin (HbA1c) levels and short-term BPV in young and middle-aged hypertensive patients over 18 years with HbA1c levels below 5.7%.Methods: We collected and analyzed data on 24-h ambulatory BP monitoring, demographic, epidemiological, clinical, and laboratory variables from 143 hypertensive patients. BPV was measured as the standard deviation (SD) and average real variability (ARV) in millimeters of mercury, as well as the dimensionless coefficient of variation (CV).Results: Depending on the index, each one unit increase in nighttime SD and CV indices was associated with a 17-24% higher likelihood of elevated HbA1c levels (higher than 5.2%). Regarding BPV dipping, each 1% decrease in nighttime SD and CV dipping was associated with a 10-20% higher risk of increased HbA1c levels. Additionally, each 1% decrease in nighttime ARV DBP dipping was also associated with a 10% higher risk of elevated HbA1c levels. A one-standardized-unit increase in the overall combined BPV index, as a pooled measure of BPV, was associated with a 45% higher likelihood of raised HbA1c levels.Conclusion: Even within the optimal range, elevated HbA1c levels may reflect an underlying increase in BPV, which may be particularly relevant given the prognostic implications of short-term BPV.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1148-1157"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension determinants among Ghanaians differ according to location of residence: RODAM study: Erratum. 加纳人的高血压决定因素因居住地而异：RODAM研究：勘误。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.1097/HJH.0000000000004033

引用次数: 0

Within-visit blood pressure variability in children and adolescents in the National Health and Nutrition Examination Survey (2013-2020). 2013-2020年全国健康与营养检查调查中儿童和青少年访内血压变异性

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/HJH.0000000000004006

Sandeep K Riar, Scott Gillespie, Andrew M South

{"title":"Within-visit blood pressure variability in children and adolescents in the National Health and Nutrition Examination Survey (2013-2020).","authors":"Sandeep K Riar, Scott Gillespie, Andrew M South","doi":"10.1097/HJH.0000000000004006","DOIUrl":"10.1097/HJH.0000000000004006","url":null,"abstract":"Background: Blood pressure (BP) varies depending on several factors. The objective of our study was to describe within-visit BP variability (BPV) in healthy children and compare BPV between manual and automated BP readings.Methods: We included individuals aged 8-17 years with three BP readings from NHANES 2013-2020 cycles. From 2013 to 2016, BP was obtained using auscultation (manual protocol, MP) and, subsequently, using oscillometry (automated protocol, AP). We excluded individuals with DBP 'zero'.Results: In 5656 individuals [MP group: 3365 (59.5%); AP group: 2291 (40.5%]), a ΔBP (difference between highest and lowest of three BP readings) at least 5 mmHg was noted in 49.1 and 60.7% of individuals for SBP and DBP, respectively. ΔDBP at least 10 mmHg was twice as common in the MP group as in the AP group. ΔDBP at least 20 mmHg was observed in 4.4% individuals. A difference of at least 5 mmHg between the initial and averaged second and third BP readings was noted in 24.9 and 34.5% of individuals for SBP and DBP, respectively. The highest of three BP readings was the first, second, or third in 44.2, 30.5, and 25.4% of individuals, for SBP, and 42.4, 29.8, and 27.7%, for DBP respectively.Conclusion: Less than half of individuals had three DBP readings within 5 mmHg and some had ΔBP at least 20 mmHg. Initial BP is not always the highest; inclusion of the second and third BP readings may be more representative of the individual's actual BP. DBPV was higher with manual than with automated BP measurement.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1158-1168"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DDX17 deficiency inhibits the proliferation and migration of vascular smooth muscle cells by inhibiting RHEB/mTORC1-mediated glycolysis and oxidative stress. DDX17缺乏通过抑制RHEB/ mtorc1介导的糖酵解和氧化应激，抑制血管平滑肌细胞的增殖和迁移。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI: 10.1097/HJH.0000000000004043

Ying Li, Chenming Qiu, Xi Wu, Sheng Hu

{"title":"DDX17 deficiency inhibits the proliferation and migration of vascular smooth muscle cells by inhibiting RHEB/mTORC1-mediated glycolysis and oxidative stress.","authors":"Ying Li, Chenming Qiu, Xi Wu, Sheng Hu","doi":"10.1097/HJH.0000000000004043","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004043","url":null,"abstract":"As an RNA-binding protein, DEAD-box RNA helicase 17 (DDX17) plays a critical role in influencing gene expression and participates in the proliferation and migration of several cell lines. The current study aims to investigate the role of DDX17 in vascular smooth muscle cell (VSMC) proliferation and migration and vascular intimal hyperplasia. DDX17 expression was upregulated in injured mouse arteries and platelet derived growth factor (PDGF)-BB-treated VSMCs. An adeno-associated virus serotype 9 vector carrying Ddx17 short hairpin RNA (shDdx17) was used to silence DDX17 expression in vivo. DDX17 silencing significantly ameliorated injury-induced mouse vascular intimal hyperplasia. In vitro, the recombinant lentivirus carrying Ddx17 shRNA (Len-Ddx17i) was used to inhibition DDX17 expression in VSMCs. DDX17 deficiency inhibited PDGF-BB-induced phenotypic switching of VSMCs. Bioinformatics analysis revealed that DDX17 expression is closely related to glucose metabolism- and oxidative stress-associated pathways. Next, we found that glycolysis and oxidative stress were both attenuated by DDX17 ablation in VSMCs. Mechanically, reduced ras homolog enriched in brain (RHEB) expression and decreased mammalian target of rapamycin complex 1 (mTORC1) activity were observed after silencing of DDX17 in PDGF-BB-challenged VSMCs. Upregulating RHEB expression or elevating mTORC1 activity abolished the inhibitory effects of DDX17 silencing on PDGF-BB-induced glycolysis, oxidative stress, proliferation, and migration in VSMCs. Furthermore, the decreased mTORC1 activity induced by DDX17 deficiency was also reversed by RHEB overexpression. In conclusion, DDX17 silencing attenuates VSMC proliferation and migration by inhibiting RHEB/mTORC1-mediated glycolysis and oxidative stress, thus suppressing vascular intimal hyperplasia.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 7","pages":"1232-1246"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension accelerates the development of a diabetic nephropathy model with more relevant clinical features in Dahl salt-sensitive rat. 在达尔盐敏感大鼠中，高血压加速了具有更相关临床特征的糖尿病肾病模型的发展。

IF 3.3 2区医学

Journal of Hypertension Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI: 10.1097/HJH.0000000000004038

Lijun Hu, Jing Li, Weizhi Wang, Yong Li, Baohua Gu, Yao Tian, Qiyan Ruan, Juncheng Deng

{"title":"Hypertension accelerates the development of a diabetic nephropathy model with more relevant clinical features in Dahl salt-sensitive rat.","authors":"Lijun Hu, Jing Li, Weizhi Wang, Yong Li, Baohua Gu, Yao Tian, Qiyan Ruan, Juncheng Deng","doi":"10.1097/HJH.0000000000004038","DOIUrl":"10.1097/HJH.0000000000004038","url":null,"abstract":"Objective: Diabetic nephropathy is becoming an increasing health problem and the major cause of chronic kidney disease. The lack of experimental models that reproduce all structural and functional alterations of human diabetic nephropathy is one of the barriers to solve these clinical needs in basic research. We aimed to establish a simple and rapid method for diabetic nephropathy induction in Dahl salt-sensitive rats and achieved more clinical relevant features.Methods and results: Six or seven-week-old male Dahl salt-sensitive rats were used to induce diabetes by a single injection of streptozotocin (STZ; 45 mg/kg, intraperitoneally). After 7 days, rats with diabetes (will refer as STZ-DS rats) will be used for further studies. STZ-DS rats will be grouped and were fed with water or water containing 0.3%/0.9%/2% NaCl and a regular chow throughout the study. We found that STZ-treated Dahl salt-sensitive rat fed with 0.9% NaCl in drinking water (STZ-DS + 0.9% NaCl) displayed most of the characteristics of human diabetic nephropathy and the model meets the criteria of the diabetic nephropathy standards proposed by Animal Models of Diabetic Complications Consortium (AMDCC); which includes a 10-fold increase in albuminuria, more than 50% decline in estimated glomerular filtration rate over the lifetime, hypertrophy, thickening of the glomerular basement membrane, expansion of the mesangial matrix, any degree of arteriolar hyalinosis, severe glomerulosclerosis, and tubulointerstitial fibrosis.Conclusion: STZ-DS + 0.9% NaCl is an improved diabetes nephropathy model and more suited for the study of the signaling pathways and mechanisms in the progression of diabetes-induced renal disease. The model will facilitate the development of new therapies for diabetes nephropathy.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1225-1231"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0