Journal of Hypertension最新文献

{"title":"Prediction of blood pressure response through arterial stiffness in 'supersized smokers' undergoing renal denervation: a needle in a haystack.","authors":"Aliki Zografou, Grigoris Lachanas, Rafaella Paparidou, Olga Kourti, Vanessa Antoniadou, Ilektra Oikonomopoulou, Elias Sanidas, Costas Thomopoulos","doi":"10.1097/HJH.0000000000004147","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004147","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 11","pages":"1899"},"PeriodicalIF":4.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of malignant hypertension due to sarcoidosis.","authors":"Sosuke Kinomura, Takafumi Toyohara, Yuki Chiba, Hidekazu Aoki, Yusuke Ishizuka, Yuji Noguchi, Saori Kin, Maho Akiu, Koichi Kikuchi, Rui Makino, Mai Yoshida, Yuji Oe, Tasuku Nagasawa, Koji Okamoto, Mariko Miyazaki, Hiroshi Sato, Kei Takase, Takaaki Abe, Tetsuhiro Tanaka","doi":"10.1097/HJH.0000000000004110","DOIUrl":"10.1097/HJH.0000000000004110","url":null,"abstract":"<p><p>Sarcoidosis is a systemic inflammatory disease that is difficult to diagnose. This report describes a 54-year-old man who presented with an incidental finding of abnormal hilar shadows on imaging, indicating sarcoidosis. During follow-up, he experienced a sudden blood pressure increase (210/140 mmHg) accompanied by headaches, nausea, hypertensive retinopathy, and renal dysfunction, diagnosed as malignant hypertension. Contrast-enhanced computed tomography (CT) revealed wedge-shaped areas of poor enhancement in both kidneys, suggesting impaired perfusion due to interlobar artery compression. Renal biopsy showed noncaseating epithelioid cell granulomas, confirming renal sarcoidosis. After prednisolone treatment, the active renin concentration decreased from 265 pg/ml to 89 pg/ml, and the renal perfusion abnormalities improved on repeat CT. Renovascular hypertension due to sarcoidosis nodules disrupting the interlobar artery strongly suggests the cause of malignant hypertension. This is the first reported case of malignant hypertension due to renal sarcoidosis. Therefore, sarcoidosis should be considered as a differential diagnosis in patients with malignant hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1721-1725"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We are what we eat.","authors":"Mohammad Qasim Minhas, Rayaz A Malik","doi":"10.1097/HJH.0000000000004097","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004097","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 10","pages":"1619"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sex differences in the association between cerebral small vessel disease, hypertension and cognitive decline.","authors":"Ella Hastings, Adam S Greenstein","doi":"10.1097/HJH.0000000000004095","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004095","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 10","pages":"1617-1618"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term risk of adverse events in patients discharged alive after hospitalization for hypertensive crisis.","authors":"Tommaso Bucci, Steven H M Lam, Antonios A Argyris, D Gareth Beevers, Eduard Shantsila, Alena Shantsila, Gregory Y H Lip","doi":"10.1097/HJH.0000000000004113","DOIUrl":"10.1097/HJH.0000000000004113","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the long-term clinical course of patients presenting with hypertensive crisis discharged alive from hospital.</p><p><strong>Methods: </strong>Retrospective study utilizing TriNetX. Based on the ICD-10-CM codes recorded between 2000 and 2022, patients with hypertensive crisis were subdivided into hypertensive urgencies (HU) and hypertensive emergencies (HE). In those with HE, the type of target organ damage was reported, i.e. central nervous system (ischemic or haemorrhagic stroke and hypertensive encephalopathy), cardiovascular (myocardial infarction (MI), heart failure (HF), aorta dissection (AD)), or renal (acute kidney failure). Primary outcomes were the one-year risks of all-cause death, and major cardiovascular events (MACE: MI, stroke, cardiac arrest, AD, and HF). Secondary outcomes were the risks for each type of MACE and the incident risk of Atrial Fibrillation (AF). Cox regression analysis after propensity score matching (PSM) 1 : 1 was used to produce hazard ratios (HRs) and 95% Confidence Intervals (95%CIs).</p><p><strong>Results: </strong>Overall, we identified 27 721 patients with HE (age 62.4 ± 15.7, 46.3% females) and 23 478 patients with HU (age 63.4 ± 17.3, 55.8% females). After PSM, patients with HE showed a higher risk of all-cause death [hazard ratio (HR), 1.33, 95% confidence internal (CI) 1.24-1.44] and MACE (HR 4.00, 95% CI 3.79-4.22), vs. those with HU. Of the secondary outcomes, patients with HE had increased risks of MI, stroke, cardiac arrest, AD, acute HF, AD and incident AF. All the different types of organ involvement were associated with similar long-term risks of adverse events. During follow-up, 4% of patients with HU progressed to HE. Young age, female sex, Black or Asian ethnicity, smoking, secondary hypertension, diabetes and chronic kidney disease were identified as the main risk factors.</p><p><strong>Conclusion: </strong>Patients with HE have a high long-term risk of all-cause death, MACE and incident AF. Preventing the onset of target organ damage in patients with hypertensive crisis is crucial to mitigate their long-term risk of adverse events.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1703-1710"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of TLR7 contributes to the development of preeclampsia through suppression of the PI3K-Akt signaling pathway.","authors":"Xiaowei Zhang, Shilin Zhong, Ping Yang, Xinyang Liu, Jinli Lyu, Yuzhen Ding, Qiaoli Feng, Yiheng Liang, Ping Liu, Chunfeng Liu, Yanlan Wang, Yuxia Zhu, Liting Huang, Zhansong Xiao, Pingyue Zhao, Qing Li, Kaidong Ma, Shangrong Fan","doi":"10.1097/HJH.0000000000004099","DOIUrl":"10.1097/HJH.0000000000004099","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to uncover key genes contributing to preeclampsia development and elucidate their underlying mechanisms.</p><p><strong>Methods: </strong>We conducted transcriptome analysis of placental tissues from preeclampsia patients and healthy pregnancies. Pregnant mice were administered a TLR7 agonist to induce preeclampsia-like symptoms. Additionally, we over-expressed TLR7 in HTR8/Svneo cells to assess its effects on cell functions. Co-analysis of transcriptomic differences between TLR7 agonist-treated mice, oe-TLR7 cells, and corresponding control groups was performed to identify key regulatory pathways.</p><p><strong>Results: </strong>Our findings revealed that the Toll-like receptor (TLR) signaling pathway may serve as a central network hub, with TLR7 being the only significantly altered TLR between preeclampsia and healthy pregnancies. In-vivo studies showed that TLR7 agonist administration in pregnant mice induced preeclampsia -like symptoms, including elevated blood pressure and increased levels of sFlt and sEng. In-vitro experiments demonstrated that over-expression of TLR7 in HTR8/Svneo cells resulted in reduced cell proliferation and migration. Transcriptomic analysis identified the PI3K-Akt signaling pathway as a central regulator that significantly altered following TLR7 over-expression. Activation of the P53 signaling pathway and decreased expression of THBS2/col-IV were found to be potentially regulated by PI3K-Akt signals, further suppressing trophoblast migration and invasion. These effects contribute to superficial placental implantation and compromised uterine perfusion, ultimately leading to the development of preeclampsia.</p><p><strong>Conclusion: </strong>Our study suggests that the over-activation of TLR7 may play a significant role in preeclampsia development and could be a potential therapeutic target, providing a theoretical basis for the development of novel treatments for preeclampsia.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1675-1685"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting response to renal denervation: aortic distensibility as a piece of the puzzle.","authors":"Umut Selda Bayrakci","doi":"10.1097/HJH.0000000000004103","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004103","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 10","pages":"1620-1621"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive quantification of aortic wave reflection timing indices in aging: a study combining MRI and applanation tonometry.","authors":"Emilie Bollache, Ioannis Bargiotas, Alain Giron, Alain De Cesare, Gilles Soulat, Elie Mousseaux, Nadjia Kachenoura","doi":"10.1097/HJH.0000000000004088","DOIUrl":"10.1097/HJH.0000000000004088","url":null,"abstract":"<p><strong>Objective: </strong>To study associations of newly proposed noninvasive central arterial wave reflection timing indices with age and reference indices of reflection magnitude, using superimposed MRI aortic flow and applanation tonometry carotid pressure waveforms.</p><p><strong>Methods: </strong>Consecutively acquired MRI flow and tonometry pressure waveforms were superimposed in 113 volunteers [56 women, age: 43 ± 16 (19-81) years] free from overt cardiovascular disease except for hypertension, after registration and interpolation to averaged cardiac cycle duration using a custom interface to derive time to peak flow ( TQmax ) and pressure ( TPmax ). Conventional time to return of reflected pressure wave ( Ti ), augmentation index (AIx) and reflection magnitude (RM) were further measured and used as reference.</p><p><strong>Results: </strong>TQmax occurred slightly earlier, whereas TPmax appeared later in the cardiac cycle with age, resulting in significant, independent age-related decrease in TQmax to Ti ( r  = -0.63, P  < 0.0001) and increase in TQmax to TPmax ( r  = 0.61, P  < 0.0001) delays. Such delays were further significantly and independently related to reference AIx ( Ti  -  TQmax : r  = -0.66, P  < 0.0001; TPmax  -  TQmax : r  = 0.78, P  < 0.0001) and RM ( Ti  -  TQmax : r  = -0.55, P  < 0.0001; TPmax  -  TQmax : r  = 0.76, P  < 0.0001). Correlations obtained with TPmax  -  TQmax were overall higher than those obtained with conventional Ti timing (age: r  = -0.52, P  < 0.0001; AIx: r  = -0.77, P  < 0.0001; RM: r  = -0.42, P  < 0.0001).</p><p><strong>Conclusion: </strong>Combination of noninvasive flow and pressure time domain waveforms was able to reliably capture central wave reflection timing indices as demonstrated by strong and independent associations with age and gold standard measures of reflection magnitude. Such timing, which was based on straightforward peaks detection, could be used to explore and better understand left ventricular-aortic coupling in cardiovascular conditions presenting increased reflections.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1658-1665"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic volatility in children and young adults with down syndrome during procedural sedation.","authors":"Justin Abe, Panteha Hayati Rezvan, Benjamin N Vogel, Lilia Kazerooni, Maeve C Lucas, Mariam M Yousuf, Mackenzie Silverman, Deepti Nagesh, Saba Jafarpour, Jonathan D Santoro","doi":"10.1097/HJH.0000000000004107","DOIUrl":"10.1097/HJH.0000000000004107","url":null,"abstract":"<p><strong>Objective: </strong>Individuals with Down syndrome (DS) have been reported to have lower systemic blood pressure compared to individuals without DS. This study sought to retrospectively evaluate biomedical parameters in patients with DS undergoing procedural sedation compared to non-DS controls.</p><p><strong>Methods: </strong>A retrospective observational study was performed comparing children and young adults with DS ( n  = 150) and age-matched non-DS patients ( n  = 146) who underwent procedural sedation. Demographics, comorbidities, and diagnostic studies were assessed, along with preprocedural baseline, median procedural, and procedural nadir systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP). The average rate of change in SBP and DBP from baseline to nadir was also examined between the two groups.</p><p><strong>Results: </strong>Although baseline SBP, DBP, and PP were comparable between the two groups, individuals with DS showed lower median procedural SBP and DBP ( P  < 0.001) as well as lower procedural nadir SBP, DBP, and PP ( P  < 0.001). Consistent results were found for median SBP ( P  = 0.006) and nadir SBP ( P  = 0.006) percentiles. Notably, the reduction from baseline to nadir during sedation was larger in individuals with DS for both SBP (mean difference [95% CI]: -12.3 [-16.1, -8.6]) and DBP (-10.2 [-13.3, -7.0]) compared to the non-DS controls. These differences remained consistent even after adjusting for demographic factors.</p><p><strong>Conclusions: </strong>Children and young adults with DS exhibited significantly larger blood pressure drops during procedural sedation. Additional research is warranted to investigate the clinical significance of these findings, including the potential for decreased cerebral blood flow in this population during sedation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1695-1702"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term and long-term blood pressure variabilities. Are they related to each other?","authors":"Paolo Palatini","doi":"10.1097/HJH.0000000000004090","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004090","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 10","pages":"1731-1732"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}