Journal of Hypertension最新文献

{"title":"Development of the European Society of Hypertension guidelines for the management of arterial hypertension: comparison of the helpfulness of ESH 2013, 2018, and 2023 guidelines.","authors":"Akos Koller, Zoltán Járai, Johanna Takács","doi":"10.1097/HJH.0000000000003985","DOIUrl":"10.1097/HJH.0000000000003985","url":null,"abstract":"<p><strong>Objective: </strong>Over the last decade, the European Society of Hypertension (ESH) published several guidelines (GLs) for the Management of Arterial Hypertension (2013, 2018, and 2023). We hypothesized that the GL has been improved because of the publications of new evidence. Thus, we aimed to examine the development of ESH guidelines (ESH GLs) by comparing their helpfulness regarding the diagnosis and treatment of hypertension.</p><p><strong>Methods: </strong>A novel mathematical analysis was used to compare ESH GLs. Not only the frequency of Classes of Recommendations (CLASS) and the Levels of Evidence (LEVEL) were examined but a newly developed certainty index (CI) was calculated. This CI allows the CLASS and LEVEL to be assessed together, providing a less biased assessment of GLs, than examining the CLASS and LEVEL independently or related to each other.</p><p><strong>Results: </strong>The number of recommendations showed continuous and significant increases from 2013 ( N  = 110) to 2018 ( N  = 169), and 2023 ( N  = 269). Examining the frequency of CLASS and/or LEVEL led to biased results, showing both improvements and/or worsening comparing years. However, based on the new analysis, a continuous improvement was shown in the percentage of certainty from 2013 to 2023 (2013: 60.5%, 2018: 72.1%, 2023: 75.3%). Accordingly, the CI was also significantly increased from 2013 (CI: 0.21), to 2018 (CI: 0.44), and to 2023 (CI: 0.51).</p><p><strong>Conclusion: </strong>The analysis shows that compared to previous GLs, the structure of the ESH 2023 GL has been rearranged and simplified. The higher number of Recommendations indicates a continuously accumulating knowledge regarding the mechanisms, clinical findings, and epidemiology of hypertension. Moreover, the ESH 2023 GL shows a higher degree of certainty and CI, corresponding to a higher level of helpfulness of the ESH 2023 GL for healthcare professionals to diagnose, prevent, and treat hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"852-858"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chill factor: effect of thermoneutrality on thoracic perivascular adipose tissue and vascular reactivity.","authors":"Sophie N Saxton","doi":"10.1097/HJH.0000000000003983","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003983","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 5","pages":"750-751"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma renin activity: blood pressure steps or salt-sensitivity slopes - or both?","authors":"Peter Bie","doi":"10.1097/HJH.0000000000003991","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003991","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 5","pages":"747-749"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe neurovascular hypertension in a 17-year-old girl cured by microvascular decompression.","authors":"Maximilian Middelkamp, Paula-Sophie Steffens, Valentina Vogelsang, Raphael Schild, Jens Gempt, Ania C Muntau, Lasse Dührsen","doi":"10.1097/HJH.0000000000003986","DOIUrl":"10.1097/HJH.0000000000003986","url":null,"abstract":"<p><p>We report a rare case of centrally caused hypertension in a 17-year-old adolescent due to neurovascular compression of the root entry/exit zone of the ninth/tenth cranial nerves of the rostral ventrolateral medulla oblongata on the left side. The patient underwent a comprehensive diagnostic workup to exclude other causes of secondary hypertension. A cranial magnetic resonance imaging (cMRI) indicated a neurovascular compression. The patient underwent microvascular decompression (MVD) twice. After the first MVD, blood pressure values significantly decreased to normotensive levels without any antihypertensive medication. After one year without clinical symptoms, the patient experienced recurrent hypertension and underwent a second MVD. Again, the blood pressure normalized without any medication or clinical symptoms within six-month follow-up. This case report highlights neurovascular compression at brainstem level as an important differential diagnosis of centrally caused hypertension, even in the absence of specific cranial nerve deficits. MVD is an effective treatment option.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"904-908"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway.","authors":"Liang-Liang Tang, Xin-Yu Xu, Mei Zhang, Qi Qin, Rong Xue, Shuai Jiang, Xu Yang, Chen Liang, Qiu-Shi Wang, Chang-Jiang Yu, Zhi-Ren Zhang","doi":"10.1097/HJH.0000000000003979","DOIUrl":"10.1097/HJH.0000000000003979","url":null,"abstract":"<p><strong>Background and purpose: </strong>Ponatinib, a tyrosine kinase inhibitor (TKI) leads to hypertension; however, the mechanisms remain elusive. We aimed to investigate whether lysine acetyltransferase 7 (KAT7), a key regulator of cellular senescence that is closely associated with cardiovascular diseases, involves in ponatinib-induced hypertension.</p><p><strong>Methods and results: </strong>After administering ponatinib to Sprague-Dawley (SD) rats for 8 days, we measured blood pressure, vasodilation, and endothelial function using tail-cuff plethysmography, isometric myography, and the Total NO Assay kit, respectively. The results indicated that ponatinib increased blood pressure, impaired endothelium-dependent relaxation (EDR), and caused injury to endothelial cells in SD rats. Furthermore, PCR and Western blot experiments demonstrated an upregulation of KAT7 expression in rat mesenteric artery endothelial cells (MAECs) following ponatinib treatment. To further study the role of KAT7 in ponatinib-induced hypertension, we divided the SD rats into four groups: control, ponatinib, WM-3835 (a KAT7 inhibitor), and ponatinib plus WM-3835. Notably, WM-3835 administration significantly improved ponatinib-induced hypertension and EDR dysfunction in SD rats. Mechanistically, over-expression of KAT7 (OE-KAT7) in MAECs led to cellular senescence and inflammation, phenomena that were also observed in the mesenteric arteries of ponatinib-treated rats and in MAECs exposed to ponatinib. However, WM-3835 mitigated these detrimental effects in both in vivo and in vitro experiments. Additionally, both OE-KAT7 and ponatinib treatment induced H3K14 acetylation (H3K14ac), with OE-KAT7 also elevating the recruitment of the H3K14ac to the p21 promoter. Moreover, BAY 11-7085, a nuclear factor (NF)-κB inhibitor, potently alleviated the accumulation of IL-6 and IL-8, as well as endothelial cell senescence induced by ponatinib and KAT7 overexpression.</p><p><strong>Conclusion: </strong>Our data indicate that ponatinib-induced elevation of KAT7 led to endothelial cells senescence and inflammatory responses through H3K14 acetylation and NF-κB signaling pathway, subsequently caused vasotoxicity and hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"827-840"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of plateau heart disease misdiagnosed as chronic pulmonary heart disease.","authors":"Na Zhang, Feng Tang","doi":"10.1097/HJH.0000000000004018","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004018","url":null,"abstract":"<p><p>This paper reports a case of plateau heart disease in Qinghai-Tibetan plateau who had recurrent symptoms of chest tightness and shortness of breath for 6 years but was misdiagnosed as chronic pulmonary heart disease. Plateau heart disease was diagnosed by thoracic computed tomography, pulmonary arteriography, pulmonary function tests and examination of medical history. Through the detailed analysis and differential diagnosis of this case, the aim is to distinguish between high-altitude heart disease and high-altitude chronic pulmonary heart disease, with the hope of achieving new breakthroughs in the diagnosis and treatment of this condition in the future.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study.","authors":"Jun Qian, Zhongzheng Zhou, Yiwen Zheng, Shunkang Rong, Yuanqing Yao, Bo Xiong, Weiran Dai, Yun Du, Han Liu, Wei Sha, Dichuan Liu, Changming Deng, Jing Huang","doi":"10.1097/HJH.0000000000004005","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004005","url":null,"abstract":"<p><p>This study aimed to evaluate the feasibility and efficacy of a catheter-based ultrasound renal denervation (RDN) system for nerve mapping guided RDN and treatment efficacy verification. A total of five patients were sequentially enrolled. Low-power pulsed ultrasound stimulation was applied at the distal, middle and proximal segments of the renal arteries, in both head-foot and abdomen-back directions. Ultrasound RDN was selectively performed at sites where SBP increased by at least 5 mmHg following stimulation. Supplementary RDN was conducted at any sites exhibiting an SBP increase of at least 5 mmHg after re-stimulation. A total of 60 directional stimulations were applied across 10 renal arteries, with 70% of these directions received ultrasound RDN. The daytime ambulatory SBP decreased from 151 to 130 mmHg after two months. These findings indicate that catheter-based ultrasound renal mapping guided RDN might feasible and could offer a more targeted approach to the RDN procedure.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in blood pressure lowering of initial treatment with ultra-low dose combination therapy versus monotherapy. A secondary analysis of QUARTET.","authors":"Edel T O'Hagan, Simone L Marschner, Desi Quintans, Graham S Hillis, Emily R Atkins, Sarah Zaman, Markus P Schlaich, Anthony Rodgers, Clara K Chow","doi":"10.1097/HJH.0000000000004024","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004024","url":null,"abstract":"<p><p>Women with hypertension are more likely than men to have ineffective treatment where blood pressure (BP) is treated but not controlled. The aim of this study was to investigate whether a quadpill based strategy differs between males and females. A secondary analysis of The Quadruple UltrA-low-dose tReaTment for hypErTension (QUARTET); randomized controlled trial. In this analysis the primary outcome was sex differences in unattended office systolic BP at 12 weeks. The QUARTET study recruited 591 participants (40% female) with mean age 59 (standard deviation 12) years [male 57 (12); female 62 (11)]. Males and females recorded a similar reduction in unattended systolic BP at 12 weeks with no interaction between group allocation and sex [male:mean difference (MD) in mmHg -6.95 (95% CI -9.53 to -4.38), female: MD -6.34 (95% CI -9.50 to -3.18), interaction P = 0.77]. The quadpill strategy was similarly effective in men and women. Initiating BP control with a quadpill in women presents a promising approach to achieving similar BP control levels to men.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular events and biochemically negative paragangliomas: a systematic review.","authors":"George Tsorbatzoglou, Foteini Thanasoula, Chrysoula Mytareli, Elisavet Tasouli, Alexandros Smyrnis, Konstantinos Kontzoglou, Gregory Kaltsas, Anna Angelousi","doi":"10.1097/HJH.0000000000004026","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004026","url":null,"abstract":"<p><strong>Objective: </strong>To study cardiovascular morbidity in patients with biochemically inactive pheochromocytomas/paragangliomas.</p><p><strong>Methods: </strong>PubMed, Cochrane, and Scopus databases were searched by two independent reviewers to identify relevant studies. Twenty-four case reports (n = 24 patients) met the inclusion criteria providing data on the cardiovascular status of biochemically negative pheochromocytomas/paragangliomas patients. Methodological quality was assessed by the Grading of Recommendations, Assessment, Development and Evaluations system, and all included studies were assessed for the risk of bias. This systematic review was conducted in conformance with the PRISMA statement and registered to PROSPERO (ID: CRD42024530601).</p><p><strong>Results: </strong>Almost half of patients (46%) presented objective abnormal findings on noninvasive cardiovascular examination performed routinely before surgery, whereas 67% complained of pheochromocytoma/paraganglioma-related symptoms (angina, headache, diaphoresis, shortness of breath, palpitations) and exhibited relevant clinical signs (hypertension, tachycardia, tachypnea, pallor). Preoperatively, only 38% of patients with biochemically negative pheochromocytomas/paragangliomas were treated with alpha-blockers, 25% did not receive any pharmaceutical preparation whereas data were not available for the remaining 37% of patients. Following an uneventful surgery, 70% of patients exhibited resolution of the preoperatively detected cardiovascular symptoms and signs.</p><p><strong>Conclusion: </strong>The high occurrence of cardiovascular abnormalities in patients with pheochromocytomas/paragangliomas characterized as \"biochemically negative\" based on routine biochemical analyses highlights the difficulty in the appropriate classification of these tumors regarding their secretory profile and thus the risk of missing cardiovascular system involvement with potentially deleterious effects.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health financing interventions and hypertension control: a narrative review and hypothetical model.","authors":"Krishna D Rao, Matti Marklund, Rajeev Cherukupalli, Zhiqi Yao, Ahmad Khairul Abrar, Shamim Jubayer, Sohel Reza Choudhury, Lawrence J Appel, Kunihiro Matsushita","doi":"10.1097/HJH.0000000000004021","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004021","url":null,"abstract":"<p><p>Financial incentives have been used extensively in low-income and middle-income countries (LMICs) to improve health and service coverage. Little is known about their effectiveness in improving hypertension outcomes. We conducted a narrative literature review to document features of select supply-side (pay-for-performance, capitation) and demand-side [conditional cash transfers (CCT), vouchers] financing interventions focused on improving hypertension outcomes in primary care settings. Our review confirmed the paucity of studies, especially from LMICs. Pay-for-performance and capitation had small effects on screening, prescription practices, and blood pressure (BP) control. CCTs had mixed effects on screening and modest effects on BP control. Information on causal pathways, unintended consequences, and the use of vouchers was sparse. We then developed a conceptual model identifying pathways through which financing interventions influence hypertension outcomes. Based on this model, simulations in the context of Bangladesh indicated that pay-for-performance demands substantial financial resources but could become more favorable with increased treatment coverage.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}