Journal of Hypertension最新文献

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A small step forward for better patient selection in renal denervation. 为更好地选择肾去神经手术患者迈出了一小步。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1097/HJH.0000000000004077
Iskren Garvanski
{"title":"A small step forward for better patient selection in renal denervation.","authors":"Iskren Garvanski","doi":"10.1097/HJH.0000000000004077","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004077","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 10","pages":"1615-1616"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise blood pressure in adults with high-risk left ventricular hypertrophy: the importance of normalizing blood pressure to oxygen uptake. 高危左心室肥厚成人的运动血压:血压正常化对摄氧量的重要性
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-07-02 DOI: 10.1097/HJH.0000000000004074
Denis J Wakeham, Diana De Oliveira-Gomes, Matthew M Howrey, Joetsaroop S Bagga, Seamus B Hughes, Tiffany L Brazile, Michinari Hieda, Erin J Howden, James P MacNamara, Benjamin D Levine, Christopher M Hearon, Satyam Sarma
{"title":"Exercise blood pressure in adults with high-risk left ventricular hypertrophy: the importance of normalizing blood pressure to oxygen uptake.","authors":"Denis J Wakeham, Diana De Oliveira-Gomes, Matthew M Howrey, Joetsaroop S Bagga, Seamus B Hughes, Tiffany L Brazile, Michinari Hieda, Erin J Howden, James P MacNamara, Benjamin D Levine, Christopher M Hearon, Satyam Sarma","doi":"10.1097/HJH.0000000000004074","DOIUrl":"10.1097/HJH.0000000000004074","url":null,"abstract":"<p><strong>Introduction: </strong>Exaggerated exercise blood pressure (EEBP) is typically defined using systolic blood pressure (SBP) thresholds at maximal exercise of ≥190 (women) and ≥210 mmHg (men). However, SBP/workload and SBP/oxygen uptake (V̇O 2 ) slopes have been shown to be more sensitive predictors of all-cause mortality and/or cardiovascular morbidity than peak exercise SBP. Hypertensive adults with left ventricular hypertrophy (LVH) often present with EEBP; whether the change in SBP with exercise is also greater when normalized for workload/V̇O 2 is unknown. Therefore, we compared absolute and normalized exercise SBP in adults with LVH and age-matched healthy controls.</p><p><strong>Methods: </strong>We measured BP (brachial electrosphygmomanometry) and V̇O 2 (indirect calorimetry) during treadmill exercise in middle-aged adults who were either healthy ( n  = 52) or had LVH and elevated cardiac biomarkers ( n  = 48). Data were compared using Welch's t-tests and Fisher's exact tests.</p><p><strong>Results: </strong>Absolute V̇O 2 max was not different between groups (LVH: 2.24 ± 0.61 vs. Healthy: 2.21 ± 0.69 l/min, P  = 0.862). Baseline ( P  < 0.001) and max SBP were higher in LVH (196 ± 25 vs. 173 ± 26 mmHg, P  < 0.001); as such EEBP incidence was higher in LVH (48 vs. 11%, P  < 0.001) when measured using the SBP thresholds. However, there was no difference in the change in SBP from rest ( P  = 0.174) nor the SBP/V̇O 2 slope between groups (LVH: 37 ± 18 vs. Healthy: 33 ± 17 mmHg/l/min, P  = 0.334).</p><p><strong>Conclusion: </strong>The greater EEBP incidence in LVH using traditional thresholds reflects differences in resting BP, not an exaggerated SBP response. Therefore, those with high-risk LVH have a normal SBP response to exercise despite achieving a higher max SBP for the same absolute V̇O 2 max.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1650-1657"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends of awareness, treatment, and control of hypertension in Peru: a 5-year national survey analysis. 秘鲁高血压的认识、治疗和控制趋势:一项5年全国调查分析
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI: 10.1097/HJH.0000000000004109
Carlos Diaz-Arocutipa
{"title":"Trends of awareness, treatment, and control of hypertension in Peru: a 5-year national survey analysis.","authors":"Carlos Diaz-Arocutipa","doi":"10.1097/HJH.0000000000004109","DOIUrl":"10.1097/HJH.0000000000004109","url":null,"abstract":"<p><p>Hypertension remains a major public health challenge, particularly in low-resource settings. We analyzed trends in hypertension awareness, treatment, and control in Peru from 2019 to 2023 using nationally representative data from 167 204 individuals aged ≥15 years. Blood pressure was measured using validated automatic digital monitors (Omron HEM-7113) following a standardized protocol, ensuring accurate and comparable measurements across participants. The overall prevalence of hypertension was 20.8%, with a mean age of 41 years and 52% were female. Awareness increased from 49.2% in 2019 to 55.4% in 2023, despite a decline in 2021. Treatment rates ranged from 27% to 33.7%, while control declined from 28.3% in 2019 to 22.5% in 2021, subsequently improving to 33% by 2023. Although average annual percentage changes in awareness (+2.3%), treatment (+0.5%), and control (+4.5%) were positive, they did not reach statistical significance. Older individuals and women demonstrated higher rates, while regional disparities persisted, with greater improvements in the Andes region. In conclusion, despite some progress, significant gaps remain, underscoring the need for targeted and equitable interventions to optimize hypertension management in Peru.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1726-1730"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The saline infusion test with mass spectrometric measurements of aldosterone to confirm primary aldosteronism. 用质谱法测定醛固酮的生理盐水输注试验来确认原发性醛固酮增多症。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-07-15 DOI: 10.1097/HJH.0000000000004098
Christina Pamporaki, Hanna Remde, Georgiana Constantinescu, Lydia Kürzinger, Carmina Fuss, Sybille Fuld, Mirko Peitzsch, Manuel Schulze, Francesco Alessi, Myron Lee, Jun Yang, Tracy Ann Williams, Denise Brüdgam, Martin Reincke, Sven Gruber, Felix Beuschlein, Jacques W M Lenders, Graeme Eisenhofer
{"title":"The saline infusion test with mass spectrometric measurements of aldosterone to confirm primary aldosteronism.","authors":"Christina Pamporaki, Hanna Remde, Georgiana Constantinescu, Lydia Kürzinger, Carmina Fuss, Sybille Fuld, Mirko Peitzsch, Manuel Schulze, Francesco Alessi, Myron Lee, Jun Yang, Tracy Ann Williams, Denise Brüdgam, Martin Reincke, Sven Gruber, Felix Beuschlein, Jacques W M Lenders, Graeme Eisenhofer","doi":"10.1097/HJH.0000000000004098","DOIUrl":"10.1097/HJH.0000000000004098","url":null,"abstract":"<p><strong>Objective: </strong>Confirmation of primary aldosteronism with the saline infusion test requires accurate measurements of plasma aldosterone, which is best achieved by mass spectrometry. Diagnostic performance, appropriate cut-offs and intra-patient variability of the test remain inadequately defined. The objective of this prospective multicenter cohort study was to address these limitations.</p><p><strong>Methods: </strong>Primary aldosteronism was confirmed and excluded using alternative criteria to confirmatory tests in 138 and 282 respective patients with suspected disease. Those criteria were not satisfied in 89 patients. Diagnostic performance of the saline infusion test and optimal cut-offs were determined from receiver operating characteristic curves. Intra-patient variability was determined in 57 patients.</p><p><strong>Results: </strong>Analysis of receiver operating characteristic curves indicated an area under the curve of 0.964 and a cut-off of 169 pmol/l for posttest aldosterone concentrations that provided 97% sensitivity and 89% specificity. A cut-off of 255 pmol/l enabled improved specificity of 95% at a sensitivity of 75%. Among the 57 patients in whom the saline infusion test was repeated, 15 (26%) had posttest aldosterone concentrations that were discordant using the 169 pmol/l cut-off. Eighty percent of the discordant results were from a single center. With exclusion of that center, which did not minimize ambulation during saline infusion, the area under the curve increased to 0.985 and an optimal cut-off of 169 pmol/l provided 96% specificity and sensitivity.</p><p><strong>Conclusion: </strong>The seated saline infusion test with mass spectrometric measurements of aldosterone and the cut-offs documented here provides a useful confirmatory test, although this requires adherence to standard-operating procedures.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1666-1674"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between pulse wave velocity progression and baseline heart rate and its change over 3.7 years of follow-up in hypertensive patients. 高血压患者脉搏波速度进展与基线心率的关系及其随访3.7年的变化。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1097/HJH.0000000000004106
Alessandro Maloberti, Chiara Tognola, Stefano Fumagalli, Ilaria Garofani, Michela Algeri, Atea Shkodra, Marco Bellomare, Marta Campana, Andrea Busti, Alfonso Riccio, Rita Facchetti, Guido Grassi, Michele Bombelli, Cristina Giannattasio
{"title":"Relationship between pulse wave velocity progression and baseline heart rate and its change over 3.7 years of follow-up in hypertensive patients.","authors":"Alessandro Maloberti, Chiara Tognola, Stefano Fumagalli, Ilaria Garofani, Michela Algeri, Atea Shkodra, Marco Bellomare, Marta Campana, Andrea Busti, Alfonso Riccio, Rita Facchetti, Guido Grassi, Michele Bombelli, Cristina Giannattasio","doi":"10.1097/HJH.0000000000004106","DOIUrl":"10.1097/HJH.0000000000004106","url":null,"abstract":"<p><strong>Objective: </strong>The role of resting heart rate (HR) and of its changes over time on the progression of pulse wave velocity (PWV) has not been extensively evaluated. The aim of this study was to investigate this relationship in a population of hypertensive patients in a longitudinal study.</p><p><strong>Methods: </strong>We enrolled 572 hypertensive outpatients aged 18-80, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). Anamnestic, clinical and laboratory data, BP and PWV were assessed at baseline and after a median follow-up of 3.7 ± 0.5 years.</p><p><strong>Results: </strong>At baseline, mean age was 53.9 ± 12.7 years, SBP and DBP were 141.2 ± 17.8 and 86.5 ± 10.5 mmHg, HR was 65.6 ± 10.9 bpm and PWV was 8.6 ± 2.0 m/s. Despite an improvement in BP and therapies, at follow-up, a PWV increase (ΔPWV 0.5 ± 2.2 m/s). In patients with higher ΔHR, ΔPWV was significantly higher (0.82 ± 2.22 vs. 0.27 ± 2.25 m/s, P  = 0.003). At multivariable stepwise regression, baseline HR showed a significant association with baseline PWV. However, neither HR nor ΔHR was significantly associated with ΔPWV. Same results were confirmed by mediation analysis.</p><p><strong>Conclusion: </strong>The main result of our study was that despite the presence of a significant association between baseline HR and baseline PWV, neither HR nor ΔHR was significantly associated with PWV progression (ΔPWV). On the contrary, baseline PWV and baseline BP (SBP, DBP, MBP and PP) and their changes during follow-up present significant association with an accelerated process of arterial stiffening.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1686-1694"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marked increases in systemic blood flow in resistant or refractory hypertensives of African ancestry in Africa. 非洲非洲血统的抵抗性或难治性高血压患者的全身血流量显著增加。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI: 10.1097/HJH.0000000000004114
Nico Malan, Gavin R Norton, Carlos D Libhaber, Vernice Peterson, Hamza Bello, Mohlabani Masiu, Daniel Da Silva Fernandes, Nonhlanhla H Mthembu, Keneilwe N Mmopi, Grace Tade, Ferande Peters, Patrick H C Dessein, Pinhas Sareli, Angela J Woodiwiss
{"title":"Marked increases in systemic blood flow in resistant or refractory hypertensives of African ancestry in Africa.","authors":"Nico Malan, Gavin R Norton, Carlos D Libhaber, Vernice Peterson, Hamza Bello, Mohlabani Masiu, Daniel Da Silva Fernandes, Nonhlanhla H Mthembu, Keneilwe N Mmopi, Grace Tade, Ferande Peters, Patrick H C Dessein, Pinhas Sareli, Angela J Woodiwiss","doi":"10.1097/HJH.0000000000004114","DOIUrl":"10.1097/HJH.0000000000004114","url":null,"abstract":"<p><strong>Aims: </strong>A distinct volume-dependent increase in systemic blood flow has recently been demonstrated to contribute to hypertension in groups of African ancestry. We determined whether systemic blood flow contributes to resistant or refractory hypertension (RHTN).</p><p><strong>Methods: </strong>We compared the multivariate adjusted haemodynamic correlates of blood pressure in RHTN ( n  = 100) on diuretic and other therapy, to those in age and sex-matched normotensives (NT, n  = 128), untreated hypertensives (Untreat-HTN, n  = 124), and treated-controlled hypertensives (Control-HTN, n  = 74) of African ancestry in South Africa. Haemodynamics were determined from velocity and diameter measurements in the left ventricular outflow tract, and central arterial pressures.</p><p><strong>Results: </strong>All hypertensives had higher stroke volume (SV), cardiac output (CO) and peak aortic flow (Q) compared to NT ( P  < 0.05 to <0.0001). However, RHTN had higher SV, CO and Q than Untreat-HTN and Control-HTN ( P  < 0.0001). Proximal aortic characteristic impedance (Zc) in RHTN was similar to Untreat-HTN, but greater than NT ( P  < 0.005), and Control-HTN ( P  < 0.05). In RHTN, systemic vascular resistance was lower compared NT, Untreat-HTN and Control-HTN ( P  < 0.005 to <0.0001), and total arterial compliance was higher compared to Untreat-HTN and Control-HTN ( P  < 0.02 to <0.0001). The pressure generated by the product of Q and Zc (P QxZc ) and hence aortic pulse pressure were higher in RHTN compared to NT, Untreat-HTN and Control-HTN ( P  < 0.0001), effects attributed primarily to increases in SV and Q.</p><p><strong>Conclusions: </strong>Despite the use of diuretic therapy, increases in systemic blood flow are the main determinant of RHTN in groups of African ancestry in South Africa. Novel approaches to targeting volume-dependent increases in blood flow in this population are therefore required.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1711-1720"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term prediction of blood pressure reduction after renal denervation for arterial hypertension. 动脉高血压患者肾去神经后血压降低的长期预测。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1097/HJH.0000000000004070
Paula Sagmeister, Garnik Asatryan, Luise Mentzel, Parham Shahidi, Natalie Fischer, Philipp Lurz, Karl-Philipp Rommel, Steffen Desch, Maximilian von Roeder, Stephan Blazek, Holger Thiele, Karl Fengler
{"title":"Long-term prediction of blood pressure reduction after renal denervation for arterial hypertension.","authors":"Paula Sagmeister, Garnik Asatryan, Luise Mentzel, Parham Shahidi, Natalie Fischer, Philipp Lurz, Karl-Philipp Rommel, Steffen Desch, Maximilian von Roeder, Stephan Blazek, Holger Thiele, Karl Fengler","doi":"10.1097/HJH.0000000000004070","DOIUrl":"10.1097/HJH.0000000000004070","url":null,"abstract":"<p><strong>Background: </strong>Renal denervation (RDN) has emerged as a potential therapy for lowering blood pressure (BP) in patients with arterial hypertension. However, approximately one-third of patients do not experience significant BP reductions, underscoring the need for reliable predictors of treatment response.</p><p><strong>Objectives: </strong>This study evaluated the accuracy of a previously established bivariate prediction model for prediction of 3 months BP outcomes (based on baseline 24 h BP and ascending aortic distensibility) in predicting 24 h ambulatory BP outcomes up to 12 months post-RDN.</p><p><strong>Design and methods: </strong>We conducted a predefined secondary analysis from a prospective single-centre trial (NCT02772939). Patients with resistant hypertension undergoing ultrasound-based RDN were enrolled. Invasive and noninvasive arterial stiffness markers were assessed before the procedure. BP response was evaluated at 6 and 12 months via 24 h ambulatory BP monitoring. Model performance was assessed using linear regression to predict 24 h ambulatory BP change and receiver operating curve analyses to assess the accuracy for a binary systolic ambulatory BP reduction of more than 5 mmHg.</p><p><strong>Results: </strong>Eighty patients (mean age 63 ± 9 years, baseline 24 h SBP 150 ± 12 mmHg) were enrolled into this study. At 6 months, SBP decreased by 11 ± 15 mmHg, and by 7 ± 15 mmHg at 12 months ( P  < 0.001 for both). The prediction model demonstrated high predictive accuracy at 6 months ( r2  = 0.45, AUC 0.82, P  < 0.001), which decreased at 12 months ( r2  = 0.26, AUC 0.79, P  < 0.001).</p><p><strong>Conclusion: </strong>A noninvasive bivariate model effectively predicts BP response at 6 and 12 months post-RDN. These findings may enhance patient selection and shared decision-making, warranting further validation in larger studies.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1643-1649"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of the Mediterranean-Dietary Approaches to Stop Hypertension diet vs. ultra-processed diet with health outcomes in type 2 diabetes and hypertension: new insights from a 12-month interventional study. 地中海-饮食方法停止高血压饮食与超加工饮食与2型糖尿病和高血压健康结局的相关性:一项为期12个月的干预性研究的新见解
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-05-21 DOI: 10.1097/HJH.0000000000004061
Tatiana Palotta Minari, Veridiana Vera de Rosso, Carolina Freitas Manzano, Marcelo Jamil Humsi, Louise Buonalumi Tácito Yugar, Luis Gustavo Sedenho-Prado, Tatiane de Azevedo Rubio, Lúcia Helena Bonalumi Tácito, Antônio Carlos Pires, José Fernando Vilela-Martin, Luciana Neves Cosenso-Martin, Juan Carlos Yugar-Toledo, Heitor Moreno, Luciana Pellegrini Pisani
{"title":"Correlation of the Mediterranean-Dietary Approaches to Stop Hypertension diet vs. ultra-processed diet with health outcomes in type 2 diabetes and hypertension: new insights from a 12-month interventional study.","authors":"Tatiana Palotta Minari, Veridiana Vera de Rosso, Carolina Freitas Manzano, Marcelo Jamil Humsi, Louise Buonalumi Tácito Yugar, Luis Gustavo Sedenho-Prado, Tatiane de Azevedo Rubio, Lúcia Helena Bonalumi Tácito, Antônio Carlos Pires, José Fernando Vilela-Martin, Luciana Neves Cosenso-Martin, Juan Carlos Yugar-Toledo, Heitor Moreno, Luciana Pellegrini Pisani","doi":"10.1097/HJH.0000000000004061","DOIUrl":"10.1097/HJH.0000000000004061","url":null,"abstract":"<p><strong>Background and aims: </strong>There is ongoing debate about the optimal macronutrient and micronutrient proportions for treating type 2 diabetes (T2D) and hypertension. The objective of this study was to evaluate the dietary composition of patients participating in a 12-month interventional study with follow-up. Additionally, it aimed to evaluate the interactions and correlations between diet components and anthropometric markers, laboratory markers, and blood pressure (BP). Finally, perform a qualitative analysis of daily and postmeal satiety.</p><p><strong>Methods: </strong>This experimental, analytical, and correlational study is a quaternary evaluation within a recently published longitudinal research. Eighty-four participants were divided into two groups: intervention: followed a Mediterranean-DASH diet for 12 months with follow-up at 15 months; control: no dietary changes. Parametric variables were compared using two-way ANOVA and Tukey post hoc test. Nonparametric variables were compared using Kruskal-Wallis with Dwass-Steel-Critchlow-Fligner post hoc test and Friedman with Durbin-Conover post hoc test. Parametric data were represented as mean ± standard deviation, nonparametric as median ± interquartile range. Linear regression was used for interaction/relation analysis, and Pearson test for correlation. Significance was P less than 0.05.</p><p><strong>Results: </strong>Initially, both groups consumed diets high in ultra-processed foods, rich in refined carbohydrates, saturated fats, and sodium. At the 12th visit and follow-up, the intervention group showed substantial improvement in diet quality and dietary requirements ( P  < 0.05). The control group maintained or worsened their diet quality ( P  < 0.05). At first, both groups reported high hunger and low satiety. By the 12th month, the intervention group showed significant improvements, with 88.6% reporting postmeal fullness and 75% experiencing daily satiety. Significant positive and negative correlations ( P  < 0.05) were observed in both groups. In the control group, low-density lipoprotein cholesterol (LDL-C) was correlated with trans fats and proteins; high-density lipoprotein cholesterol (HDL-C) with polyunsaturated fats; total cholesterol (TC) with proteins and monounsaturated fats; and glycated hemoglobin (HbA1c) with fibers. In the intervention group, BMI was correlated with carbohydrates; HbA1c with total fats; LDL-C with carbohydrates; glucose with proteins; TC with total fats and carbohydrates; HDL-C with total fats, polyunsaturated fats, and saturated fats; glucose with monounsaturated fats ( P  < 0.05). In the intervention group, BP, heart rate, plasma, and urinary sodium levels significantly improved over time ( P  < 0.05). However, no strong correlations between sodium intake and these markers were observed ( P  > 0.05). In contrast, the control group showed no significant changes in BP, heart rate, plasma, or urinary sodium levels over time ( P  > 0.05), nor","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1622-1642"},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in the association between hypertension, cerebral small vessel disease and cognitive decline: a narrative review. 高血压、脑血管疾病和认知能力下降相关性的性别差异:一项叙述性综述
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-03-03 DOI: 10.1097/HJH.0000000000003997
Amanpreet Kaur, Sofia Ricciardelli, Natasha Rajah, Louise Pilote
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引用次数: 0
Blood pressure variability: a review. 血压变异性:综述。
IF 4.1 2区 医学
Journal of Hypertension Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1097/HJH.0000000000004100
Spoorthy Kulkarni, Peter Sever
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引用次数: 0
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