Journal of Hypertension最新文献

{"title":"Relationship between pulse wave velocity progression and baseline heart rate and its change over 3.7 years of follow-up in hypertensive patients.","authors":"Alessandro Maloberti, Chiara Tognola, Stefano Fumagalli, Ilaria Garofani, Michela Algeri, Atea Shkodra, Marco Bellomare, Marta Campana, Andrea Busti, Alfonso Riccio, Rita Facchetti, Guido Grassi, Michele Bombelli, Cristina Giannattasio","doi":"10.1097/HJH.0000000000004106","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004106","url":null,"abstract":"<p><strong>Objective: </strong>The role of resting heart rate (HR) and of its changes over time on the progression of pulse wave velocity (PWV) has not been extensively evaluated. The aim of this study was to investigate this relationship in a population of hypertensive patients in a longitudinal study.</p><p><strong>Methods: </strong>We enrolled 572 hypertensive outpatients aged 18-80, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). Anamnestic, clinical and laboratory data, BP and PWV were assessed at baseline and after a median follow-up of 3.7 ± 0.5 years.</p><p><strong>Results: </strong>At baseline, mean age was 53.9 ± 12.7 years, SBP and DBP were 141.2 ± 17.8 and 86.5 ± 10.5 mmHg, HR was 65.6 ± 10.9 bpm and PWV was 8.6 ± 2.0 m/s. Despite an improvement in BP and therapies, at follow-up, a PWV increase (ΔPWV 0.5 ± 2.2 m/s). In patients with higher ΔHR, ΔPWV was significantly higher (0.82 ± 2.22 vs. 0.27 ± 2.25 m/s, P = 0.003). At multivariable stepwise regression, baseline HR showed a significant association with baseline PWV. However, neither HR nor ΔHR was significantly associated with ΔPWV. Same results were confirmed by mediation analysis.</p><p><strong>Conclusion: </strong>The main result of our study was that despite the presence of a significant association between baseline HR and baseline PWV, neither HR nor ΔHR was significantly associated with PWV progression (ΔPWV). On the contrary, baseline PWV and baseline BP (SBP, DBP, MBP and PP) and their changes during follow-up present significant association with an accelerated process of arterial stiffening.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between home blood pressure control status and cardiovascular prognosis in participants with left ventricular hypertrophy: the J-HOP study.","authors":"Takeshi Fujiwara, Satoshi Hoshide, Kazuomi Kario","doi":"10.1097/HJH.0000000000004101","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004101","url":null,"abstract":"<p><strong>Objective: </strong>We examined the association between home blood pressure (BP) control status and the cardiovascular disease (CVD) risk associated with left ventricular hypertrophy (LVH) in clinical practice.</p><p><strong>Methods: </strong>J-HOP (Japan Morning Surge-Home BP) Study participants underwent home BP monitoring in the morning and evening for a 14-day period and echocardiography at baseline. Controlled home BP was defined as morning SBP less than 135 mmHg and morning DBP less than 85 mmHg. LVH was defined as LV mass index greater than 115 g/m2 in males and greater than 95 g/m2 in females.</p><p><strong>Results: </strong>Among 1823 participants [mean [SD] age: 65.1 [11.6] years; 48.6% men; 82% on antihypertensive medications], 1112 (61%) showed uncontrolled BP, and 662 (36.3%) participants had LVH (233 men, 429 women). Over a median 6.8-year follow-up (11 985 person-years), 140 total CVD events occurred. In the uncontrolled BP group (n = 440), participants with LVH had higher incident rates of total CVD events compared to those without LVH, but this was not the case in the controlled BP group. Cox models suggested that LVH was associated with increased risk of total CVD events in the uncontrolled BP group [adjusted hazard ratio (aHR) 1.80, 95% confidence interval (CI) 1.17-2.75], and again, this was not the case in the controlled BP group (aHR 1.32, 95% CI 0.70-2.50).</p><p><strong>Conclusion: </strong>The CVD risk associated with LVH differed depending on the morning home BP control status. The assessment of LVH is important to optimize risk stratification of CVD in clinical practice, especially in participants with uncontrolled home BP.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of sacubitril/valsartan in Afro-descendant patients with resistant hypertension: a randomized controlled trial.","authors":"Yasmin de Souza Lima Bitar, André Rodrigues Durães, Cristiano Ricardo Bastos de Macedo, Marcela Gordilho Aras, Levi Cardozo Santos, Rogério Smith Freire de Abreu, Enilson Carmo Barbosa Dos Santos, Edimar Bocchi, Wallace Andre Pedro da Silva, Roque Aras Junior","doi":"10.1097/HJH.0000000000004075","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004075","url":null,"abstract":"<p><strong>Background: </strong>Sacubitril/valsartan (Sac-Val) has demonstrated blood pressure (BP)-lowering effects, but its role in resistant hypertension remains unclear. This study evaluated the efficacy and safety of Sac-Val compared to optimized angiotensin II receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI) therapy in Brazilian patients with resistant hypertension, predominantly Afro-descendant.</p><p><strong>Methods: </strong>In this phase III, 8-week, single-center, randomized trial, 80 adults with resistant hypertension were assigned to Sac-Val (titrated to 200 mg with an optional increase to 400 mg if BP remained >140/90 mmHg) or standard therapy (ARB/ACEI combined with other antihypertensive agents). The primary endpoint was the proportion of patients achieving BP control (<140/90 mmHg). The co-primary endpoints included mean reductions in mean sitting SBP (msSBP), mean sitting DBP (msDBP), and mean sitting pulse pressure (msPP) at week 8. Secondary outcomes assessed dose-dependent BP reduction.</p><p><strong>Results: </strong>BP control was achieved in 94.9% of patients in the Sac-Val group versus 69.2% in the control group (P = 0.03). Sac-Val significantly reduced msPP (-6.05 mmHg, P = 0.008) and showed a trend toward greater msSBP reduction (P = 0.06). The 400 mg dose resulted in the greatest BP reduction, particularly for msPP (P = 0.034). No deaths were reported.</p><p><strong>Conclusion: </strong>Sac-Val was more effective than standard therapy in achieving BP control and reducing BP in resistant hypertension, with a dose-dependent trend favoring the 400 mg regimen. These findings support Sac-Val as a potential treatment alternative for high-risk Afro-descendant patients.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive quantification of aortic wave reflection timing indices in aging: a study combining MRI and applanation tonometry.","authors":"Emilie Bollache, Ioannis Bargiotas, Alain Giron, Alain De Cesare, Gilles Soulat, Elie Mousseaux, Nadjia Kachenoura","doi":"10.1097/HJH.0000000000004088","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004088","url":null,"abstract":"<p><strong>Objective: </strong>To study associations of newly proposed noninvasive central arterial wave reflection timing indices with age and reference indices of reflection magnitude, using superimposed MRI aortic flow and applanation tonometry carotid pressure waveforms.</p><p><strong>Methods: </strong>Consecutively acquired MRI flow and tonometry pressure waveforms were superimposed in 113 volunteers [56 women, age: 43 ± 16 (19-81) years] free from overt cardiovascular disease except for hypertension, after registration and interpolation to averaged cardiac cycle duration using a custom interface to derive time to peak flow (TQmax) and pressure (TPmax). Conventional time to return of reflected pressure wave (Ti), augmentation index (AIx) and reflection magnitude (RM) were further measured and used as reference.</p><p><strong>Results: </strong>TQmax occurred slightly earlier, whereas TPmax appeared later in the cardiac cycle with age, resulting in significant, independent age-related decrease in TQmax to Ti (r = -0.63, P < 0.0001) and increase in TQmax to TPmax (r = 0.61, P < 0.0001) delays. Such delays were further significantly and independently related to reference AIx (Ti - TQmax: r = -0.66, P < 0.0001; TPmax - TQmax: r = 0.78, P < 0.0001) and RM (Ti - TQmax: r = -0.55, P < 0.0001; TPmax - TQmax: r = 0.76, P < 0.0001). Correlations obtained with TPmax - TQmax were overall higher than those obtained with conventional Ti timing (age: r = -0.52, P < 0.0001; AIx: r = -0.77, P < 0.0001; RM: r = -0.42, P < 0.0001).</p><p><strong>Conclusion: </strong>Combination of noninvasive flow and pressure time domain waveforms was able to reliably capture central wave reflection timing indices as demonstrated by strong and independent associations with age and gold standard measures of reflection magnitude. Such timing, which was based on straightforward peaks detection, could be used to explore and better understand left ventricular-aortic coupling in cardiovascular conditions presenting increased reflections.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term prediction of blood pressure reduction after renal denervation for arterial hypertension.","authors":"Paula Sagmeister, Garnik Asatryan, Luise Mentzel, Parham Shahidi, Natalie Fischer, Philipp Lurz, Karl-Philipp Rommel, Steffen Desch, Maximilian von Roeder, Stephan Blazek, Holger Thiele, Karl Fengler","doi":"10.1097/HJH.0000000000004070","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004070","url":null,"abstract":"<p><strong>Background: </strong>Renal denervation (RDN) has emerged as a potential therapy for lowering blood pressure (BP) in patients with arterial hypertension. However, approximately one-third of patients do not experience significant BP reductions, underscoring the need for reliable predictors of treatment response.</p><p><strong>Objectives: </strong>This study evaluated the accuracy of a previously established bivariate prediction model for prediction of 3 months BP outcomes (based on baseline 24 h BP and ascending aortic distensibility) in predicting 24 h ambulatory BP outcomes up to 12 months post-RDN.</p><p><strong>Design and methods: </strong>We conducted a predefined secondary analysis from a prospective single-centre trial (NCT02772939). Patients with resistant hypertension undergoing ultrasound-based RDN were enrolled. Invasive and noninvasive arterial stiffness markers were assessed before the procedure. BP response was evaluated at 6 and 12 months via 24 h ambulatory BP monitoring. Model performance was assessed using linear regression to predict 24 h ambulatory BP change and receiver operating curve analyses to assess the accuracy for a binary systolic ambulatory BP reduction of more than 5 mmHg.</p><p><strong>Results: </strong>Eighty patients (mean age 63 ± 9 years, baseline 24 h SBP 150 ± 12 mmHg) were enrolled into this study. At 6 months, SBP decreased by 11 ± 15 mmHg, and by 7 ± 15 mmHg at 12 months (P < 0.001 for both). The prediction model demonstrated high predictive accuracy at 6 months (r2 = 0.45, AUC 0.82, P < 0.001), which decreased at 12 months (r2 = 0.26, AUC 0.79, P < 0.001).</p><p><strong>Conclusion: </strong>A noninvasive bivariate model effectively predicts BP response at 6 and 12 months post-RDN. These findings may enhance patient selection and shared decision-making, warranting further validation in larger studies.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic characteristic impedance-induced increases in forward wave but not central arterial pulse pressure beyond brachial blood pressure in coronary artery disease.","authors":"Vernice R Peterson, Danelle Els, Eitzaz Sadiq, Ravi Naran, Taalib Monareng, Talib Abdool-Carrim, Ismail Cassimjee, Girish Modi, Gavin R Norton, Ferande Peters, Angela J Woodiwiss","doi":"10.1097/HJH.0000000000004094","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004094","url":null,"abstract":"<p><strong>Background: </strong>Whether coronary artery disease (CAD) associates with proximal aortic stiffness-induced increases in central arterial forward wave pressures (Pf), but not peak central arterial pulse pressure (PPc) beyond peripheral PP, is uncertain. Therefore, we aimed to investigate the relationship between CAD and aortic characteristic impedance (Zc) and Pf beyond brachial PP and PPc.</p><p><strong>Methods: </strong>From central pressure (SphygmoCor), and aortic velocity and diameter measurements (echocardiography), we compared Zc (n = 71) and central arterial pressure wave morphology (n = 189) in patients with CAD, to 210 age- and sex-matched controls, and patients with stroke or critical limb ischemia (CLI) (n = 287).</p><p><strong>Results: </strong>With adjustments for confounders, including mean arterial pressure and aortic root diameter, Zc was increased in patients with CAD compared to controls and patients with stroke or CLI (P < 0.0001). The early systolic pressures generated by the product of peak aortic flow (Q) and Zc (PQxZc), and Pf were also increased in patients with CAD compared to controls and patients with alternative arterial diseases (P < 0.0005). Enhanced PQxZc at peak PPc, rather than increases in re-reflected wave pressures, accounted for increases in Pf. After further adjustments for brachial PP or SBP, the higher Pf values in patients with CAD were retained (P < 0.01 to P < 0.0005). In contrast, although peak PPc was higher in patients with CAD or alternative arterial diseases compared to controls (P < 0.05 to P < 0.0005), these differences were abolished by further adjustments for brachial BP.</p><p><strong>Conclusion: </strong>Increases in stiffness-associated proximal aortic Zc in patients with CAD translate into increases in Pf, but not peak PPc, beyond brachial BP. Hence, the pulsatile load responsible for CAD is beyond brachial BP and poorly indexed by PPc.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise blood pressure in adults with high-risk left ventricular hypertrophy: the importance of normalizing blood pressure to oxygen uptake.","authors":"Denis J Wakeham, Diana De Oliveria Gomes, Matthew M Howrey, Joetsaroop S Bagga, Seamus B Hughes, Tiffany L Brazile, Michinari Hieda, Erin J Howden, James P MacNamara, Benjamin D Levine, Christopher M Hearon, Satyam Sarma","doi":"10.1097/HJH.0000000000004074","DOIUrl":"10.1097/HJH.0000000000004074","url":null,"abstract":"<p><strong>Introduction: </strong>Exaggerated exercise blood pressure (EEBP) is typically defined using systolic blood pressure (SBP) thresholds at maximal exercise of ≥190 (women) and ≥210 mmHg (men). However, SBP/workload and SBP/oxygen uptake (V̇O2) slopes have been shown to be more sensitive predictors of all-cause mortality and/or cardiovascular morbidity than peak exercise SBP. Hypertensive adults with left ventricular hypertrophy (LVH) often present with EEBP; whether the change in SBP with exercise is also greater when normalized for workload/V̇O2 is unknown. Therefore, we compared absolute and normalized exercise SBP in adults with LVH and age-matched healthy controls.</p><p><strong>Methods: </strong>We measured BP (brachial electrosphygmomanometry) and V̇O2 (indirect calorimetry) during treadmill exercise in middle-aged adults who were either healthy (n = 52) or had LVH and elevated cardiac biomarkers (n = 48). Data were compared using Welch's t-tests and Fisher's exact tests.</p><p><strong>Results: </strong>Absolute V̇O2 max was not different between groups (LVH: 2.24 ± 0.61 vs. Healthy: 2.21 ± 0.69 l/min, P = 0.862). Baseline (P < 0.001) and max SBP were higher in LVH (196 ± 25 vs. 173 ± 26 mmHg, P < 0.001); as such EEBP incidence was higher in LVH (48 vs. 11%, P < 0.001) when measured using the SBP thresholds. However, there was no difference in the change in SBP from rest (P = 0.174) nor the SBP/V̇O2 slope between groups (LVH: 37 ± 18 vs. Healthy: 33 ± 17 mmHg/l/min, P = 0.334).</p><p><strong>Conclusion: </strong>The greater EEBP incidence in LVH using traditional thresholds reflects differences in resting BP, not an exaggerated SBP response. Therefore, those with high-risk LVH have a normal SBP response to exercise despite achieving a higher max SBP for the same absolute V̇O2 max.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of plateau heart disease misdiagnosed as chronic pulmonary heart disease.","authors":"Na Zhang, Feng Tang","doi":"10.1097/HJH.0000000000004018","DOIUrl":"10.1097/HJH.0000000000004018","url":null,"abstract":"<p><p>This paper reports a case of plateau heart disease in Qinghai-Tibetan plateau who had recurrent symptoms of chest tightness and shortness of breath for 6 years but was misdiagnosed as chronic pulmonary heart disease. Plateau heart disease was diagnosed by thoracic computed tomography, pulmonary arteriography, pulmonary function tests and examination of medical history. Through the detailed analysis and differential diagnosis of this case, the aim is to distinguish between high-altitude heart disease and high-altitude chronic pulmonary heart disease, with the hope of achieving new breakthroughs in the diagnosis and treatment of this condition in the future.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1247-1251"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spironolactone protects against hypertension-induced renal fibrosis by promoting autophagy and inhibiting the NLRP3 inflammasome.","authors":"Lin Zhang, Jianchang Liu","doi":"10.1097/HJH.0000000000004020","DOIUrl":"10.1097/HJH.0000000000004020","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to investigate the mechanism by which spironolactone protects against hypertensive renal fibrosis.</p><p><strong>Methods: </strong>For in-vivo experiments, we established Control, SHR, and SHR+spironolactone (20 mg/kg/day) groups. For in-vitro experiments, we established Control, TGF-β1-induced (10 ng/ml), and spironolactone (1 μmol/l) intervention groups. Renal function and serum potassium, estradiol, testosterone, and plasma aldosterone levels were assessed, along with autophagy indicators LC3 and p62, and NLRP3 inflammasome-related proteins (NLRP3, Caspase-1, IL-1β and IL-18). Additionally, changes in macrophage polarization and T cell and dendritic cell populations were determined.</p><p><strong>Results: </strong>20 mg/kg/day of spironolactone effectively maintained systolic blood pressure and renal function by lowering aldosterone levels and significantly reducing testosterone levels. Hypertensive renal fibrosis was predominant in the glomeruli, tubules, and interstitium, and was associated with autophagy inhibition in renal tubules, NLRP3 inflammasome activation, both M1 and M2 macrophages polarization, with a predominant effect on M1 polarization, decreased CD4 + T cell population and CD4/CD8 ratio, and increased CD8 + T cell and dendritic cell population. Autophagy negatively regulated the NLRP3 inflammasome. Spironolactone inhibited both M1 and M2 macrophages polarization, mainly M1 macrophage polarization, reduced CD8 + T and dendritic cell population, increased CD4 + T cell population, negatively regulated the release of NLRP3 inflammasome-related proteins in macrophages, and restored autophagy in the glomeruli and renal tubules.</p><p><strong>Conclusion: </strong>Spironolactone acts on sites where the mineralocorticoid receptor is present. A dose of 20 mg/kg/day spironolactone is well tolerated and protects against hypertension-induced renal fibrosis by restoring autophagy and suppressing NLRP3 inflammasome activation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1169-1181"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A young woman with severe renovascular hypertension due to essential thrombocytosis: case report and literature review.","authors":"Ankur Jain","doi":"10.1097/HJH.0000000000004031","DOIUrl":"10.1097/HJH.0000000000004031","url":null,"abstract":"<p><p>Essential thrombocytosis is characterized by the presence of microvascular and/or thrombo-hemorrhagic complications. The heart, brain, and peripheral vasculature are the most common sites for arterial thrombosis. Renal artery thrombosis (RAT) is uncommon in essential thrombocytosis patients. We report the case of a 27-year-old primigravida, who presented with accelerated hypertension during her early pregnancy. Despite four antihypertensive medications, her blood pressure (BP) remained uncontrolled. Radiological imaging revealed a left RAT. The presence of thrombocytosis prompted evaluation for essential thrombocytosis, which was confirmed after JAK2V617F positivity and corroborative bone marrow biopsy findings. The patient was deemed ineligible for renal angioplasty. Treatment with hydroxyurea and twice-daily aspirin resulted in BP control. A review of 13 cases of essential thrombocytosis with RAT was also presented. Essential thrombocytosis should be considered in the differential diagnosis of renovascular hypertension in young (< 40 years) women in the presence of thrombocytosis, and a history of prior/concurrent thrombosis or microvascular symptoms.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1252-1255"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}