Journal of Hypertension最新文献

{"title":"The association of cardiovascular health with new-onset pulmonary hypertension and the mediating role of proteomic signatures.","authors":"Meng-Jie Zhang, Ya-Cong Bo, Jun-Zhuo Shi, Ming-Dan Xu, Xiang-Ying Suo, Cui-Cui Chen, Meng-Tong Xu, Lu-Ling Zhao, Hong-Da Zhang, Jie-Jian Kou, Xin-Mei Xie, Xiao-Bin Pang, Yong-Jian Zhu, Yi Yan, Yang-Yang He","doi":"10.1097/HJH.0000000000004409","DOIUrl":"10.1097/HJH.0000000000004409","url":null,"abstract":"<p><strong>Background: </strong>The cardiovascular health (CVH) metrics have been reported to play an important role in the development of noncommunicable chronic diseases, yet its link to pulmonary hypertension (PH) risk and the underlying biological mechanisms remain unclear. This study aimed to investigate the association of CVH with PH risk and elucidate the mediating role of plasma proteomic signatures.</p><p><strong>Methods: </strong>A total of 279 220 participants without PH at enrollment of the UK Biobank were included. Cox regression was used to quantify the association between CVH and incident PH. Proteome-wide association analysis, mediation analysis, and functional enrichment analysis were conducted to identify protein mediators. Key hub proteins were further validated at the transcriptional level through quantitative polymerase chain reaction (qPCR) in an animal model of PH, as well as at the protein level, and by macrophage-specific knockdown of interleukin (IL)-6 and CCL4 to evaluate its impact on rat pulmonary artery smooth muscle cell (PASMC) migration and proliferation.</p><p><strong>Results: </strong>Over a median 13.2-year follow-up, 1325 PH cases occurred. Compared to the lowest CVH, participants with moderate and high CVH had 59% [hazard ratio (HR): 0.41; 95% confidence interval (CI): 0.33-0.49] and 82% (HR: 0.18; 95% CI: 0.14-0.23) lower risk, respectively. Proteomic analyses revealed that this association was significantly mediated by a distinct plasma protein signature. Pathway enrichment analysis indicates that proteins are significantly enriched in inflammatory/immune pathways, and key hub proteins were identified as participating in the central mechanism pathway. In the lung tissue of PH rat models, the mRNA and protein expression levels of IL-6 and C-C motif chemokine ligand 4 (CCL4) were significantly elevated. Furthermore, functional assays demonstrated that knockdown of IL-6 or CCL4 in macrophages significantly attenuated the migration and proliferation of rat PASMCs in vitro.</p><p><strong>Conclusion: </strong>High CVH level, defined by Life's Essential 8 (LE8), is significantly linked to a reduced risk of developing PH. This protective effect is primarily mediated by a proteomic signature, revealing the role of signaling pathways such as cytokine-cytokine receptor interaction in the prevention of PH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1867-1880"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable wrist-watch type cuff oscillometric blood pressure monitors: consensus statement by the European Society of Hypertension Working Group on blood pressure monitoring.","authors":"George S Stergiou, Ariadni Menti, Kei Asayama, Anastasios Kollias, Gianfranco Parati, Aletta E Schutte, Jiguang Wang, Dagnovar Aristizabal, Roland Asmar, Grzegorz Bilo, Tomas Bothe, Christopher Clark, Kazuomi Kario, Yan Li, Richard McManus, Takayoshi Ohkubo, Paolo Palatini, Dean Picone, Daichi Shimbo, Thomas Tsaganos, Alejandro De La Sierra","doi":"10.1097/HJH.0000000000004415","DOIUrl":"10.1097/HJH.0000000000004415","url":null,"abstract":"<p><p>Wearable wristwatch-type cuff oscillometric blood pressure (BP) monitors represent a new category of BP devices and are the first wearable monitors to use established cuff-oscillometric BP measurement technology. This consensus statement by the European Society of Hypertension Working Group on BP Monitoring reviews the published evidence on their design, accuracy, validation, clinical application, and remaining research questions. Of 281 articles identified through a systematic PubMed search, 26 were relevant. Several devices are currently available; however, only two have published validation studies performed according to established standards (Omron HeartGuide and Huawei Watch D/D2). Static validation studies generally showed acceptable accuracy, whereas data on 24-h ambulatory use, in special populations, and clinical applications remain limited. Potential advantages include self-initiated measurement at home, at work, and in other settings and conditions; more convenient and repeatable 24-h ambulatory monitoring; more convenient and accurate assessment of asleep BP; capture of stress-related and other BP-related episodes. However, proper wrist position, user adherence, ambulatory performance, and clinical applications require further investigation. More research is needed to establish the accuracy and clinical utility of these novel devices and their role in improving the diagnosis and management of hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 10","pages":"1721-1731"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor John Low Reid, OBE, DM, FRCP, FRSE, FMedSci.","authors":"Anna F Dominiczak, Matthew R Walters, Anthony Michael Heagerty, George F Stergiou, Ian Wilkinson, Christian Delles","doi":"10.1097/HJH.0000000000004403","DOIUrl":"10.1097/HJH.0000000000004403","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 10","pages":"1898-1899"},"PeriodicalIF":5.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New pharmacologic and interventional horizons in hypertension and nondialysis chronic kidney disease: bridging innovation and clinical translation.","authors":"Aikaterini Damianaki, Panagiotis Iliakis, Angeliki Vakka, Emelina Stambolliu, Athanasios Sakalidis, Kyriakos Dimitriadis, Dimitrios Petras, Konstantinos Tsioufis","doi":"10.1097/HJH.0000000000004439","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004439","url":null,"abstract":"<p><p>Hypertension is highly prevalent among patients with chronic kidney disease (CKD), where it functions both as a cause and a consequence of disease progression. Renin-angiotensin-aldosterone system inhibitors remain foundational for nephroprotection, with calcium channel blockers, thiazide diuretics and mineralocorticoid receptor antagonists (MRAs) commonly added to improve blood pressure (BP) control. However, the limited efficacy of thiazides at low estimated glomerular filtration rate and the increased risk of hyperkalemia with MRAs, together with polypharmacy, and suboptimal adherence, further complicate BP management in advanced CKD. Emerging pharmacologic strategies - including nonsteroidal MRAs, aldosterone synthase inhibitors, and RNA-based therapies - offer mechanism-oriented approaches to optimize cardiorenal outcomes. Complementary interventional strategies, such as renal denervation and low-intensity shockwave intravascular lithotripsy, are being evaluated for their potential to improve BP control, while therapies targeting inflammatory pathways, enhancing natriuretic peptide signaling, or leveraging vaccine-based mechanisms may address residual risk and adherence challenges. In this review, we provide a comprehensive overview of emerging pharmacologic and interventional approaches for BP management in nondialysis CKD, highlighting mechanism-driven innovations and their potential clinical translation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the immune system in hypertension.","authors":"Eviatar Fields, Olga Berillo, Ernesto L Schiffrin","doi":"10.1097/HJH.0000000000004440","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004440","url":null,"abstract":"<p><p>The mechanisms that cause hypertension remain elusive despite more than a century of investigation. Some of its triggers include aging, sex, salt, diet, stress, experience with adversity, socio-cultural-economic disparities, and poor-quality sleep. The renin-angiotensin-aldosterone and the endothelin systems and other hormones contribute to varying degrees to the rise in BP and target organ damage. It has become increasingly recognized that inflammation and the innate and adaptive immune systems play a role in the etiopathogenesis of hypertension. We review here the participation of different cellular and molecular (genetic and epigenetic) mechanisms that play a role in hypertension via the immune system, including neutrophil extracellular traps, memory T cells, and aldosterone-modulated trained immunity mediated by monocytes/macrophages. Molecular mechanisms, including the effects of neutrophil gelatinase-associated lipocalin as an immunomodulator, and the role of isolevoglandins in mediating oxidative stress-induced activation of the adaptive immune system are analysed. We conclude by summarizing potential therapeutic avenues to address inflammation in hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal macrovascular and microvascular adaptation in healthy pregnancy, gestational diabetes, and hypertensive disorders of pregnancy.","authors":"Lorenzo Annesi, Davide Agnoletti, Emiliana Angilletta, Alessandro Baracchi, Giusy Buccomino, Debora Cromi, Elisa Montaguti, Leonardo Pieri, Gianluigi Pilu, Francesca Rosi, Federico Ruscelli, Sara Scarduelli, Giuliana Simonazzi, Sofia Vincenzi, Claudio Borghi, Federica Piani","doi":"10.1097/HJH.0000000000004414","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004414","url":null,"abstract":"<p><strong>Objective: </strong>Healthy pregnancy requires substantial vascular adaptation, yet clinically relevant vascular markers remain poorly defined. This study aimed to characterize longitudinal macrovascular and microvascular profiles during pregnancy and their association with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>A total of 166 nulliparous women were prospectively evaluated at 11-13 and 24-27 weeks' gestation. Vascular function was assessed through arterial applanation tonometry and sublingual dark-field microscopy. Blood pressure (BP) measurements in seated, supine, and standing positions were performed.</p><p><strong>Results: </strong>In healthy pregnancies, BP and arterial stiffness decreased from early to mid-pregnancy, while heart rate increased. Pregnancies that developed HDP showed higher BP and arterial stiffness already in early pregnancy, with a greater increase over time in sitting and upright BP. Microvascular parameters were similar across groups, with a trend toward endothelial glycocalyx thinning in HDP. Upright mean BP and carotid-femoral pulse wave velocity (cfPWV) showed the strongest associations with HDP and enhanced the predictive performance of the FMF score (AUC 0.84 vs. 0.71 for the FMF score alone). Vascular profiles in women who developed GDM largely overlapped with those of healthy pregnancies in cross-sectional group comparisons. However, logistic regressions identified higher second-trimester BP as an independent predictor of GDM occurrence, whereas association with arterial stiffness was inconsistent across vascular indices and adjustment models.</p><p><strong>Conclusion: </strong>HDP is characterized by early alterations in arterial stiffness and positional BP responses, which may improve risk stratification when integrated with FMF algorithm. In contrast, GDM was not associated with overt vascular dysfunction.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney-brain neural interaction in cardiorenal syndrome: insights from volume-overloaded spontaneously hypertensive rats with aorto-caval fistula.","authors":"Zuzana Honetschlägerová, Matúš Miklovič, Soňa Kikerlová, Janusz Sadowski, Zdenka Vaňourková, Petra Škaroupková, Šárka Vacková, Miloš Táborský, Filip Tichánek, Luděk Červenka","doi":"10.1097/HJH.0000000000004450","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004450","url":null,"abstract":"<p><strong>Objective: </strong>We hypothesized, first, that impairment of autoregulation of renal blood flow (RBF), glomerular filtration rate (GFR), and of the pressure-natriuresis in spontaneously hypertensive rats (SHR) is present in early phase of heart failure and precedes its decompensation. Second, that both the total renal denervation (T-RDN) and/or selective renal afferent denervation (A-RDN) would improve renal autoregulation and pressure-natriuresis in SHR with heart failure.</p><p><strong>Methods: </strong>Heart failure was elicited by volume overload achieved using aorto-caval fistula (ACF). T-RDN and A-RDN were performed 1 week after ACF creation. Two weeks later, animals were prepared for studies examining RBF, GFR, urine flow, and sodium excretion (UNaV) responses to stepwise changes in renal arterial pressure (RAP) induced by aortic clamping.</p><p><strong>Results: </strong>Basal values of RBF, urine flow, and UNaV were lower in ACF SHR than in sham-ACF SHR. In sham-ACF SHR, stepwise reductions in RAP decreased RBF and GFR, whereas in ACF SHR both parameters remained unchanged. Stepwise reductions in RAP decreased urine flow and UNaV in sham-ACF SHR and ACF SHR, with greater decrease in the former. T-RDN as well as A-RDN increased basal urine flow and UNaV and improved the pressure natriuresis compared with innervated ACF SHR.</p><p><strong>Conclusion: </strong>In this model of heart failure, renal hemodynamics autoregulation is preserved, suggesting that heart failure decompensation cannot be simply ascribed to impaired autoregulatory capacity. Both T-RDN and A-RDN enhanced the pressure-natriuresis in ACF SHR, suggesting an important role of kidney-brain neural interactions in the pathophysiology of HF.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromuscular dysplasia and aortic involvement: a systematic review for a potential association.","authors":"Marialuisa Zedde, Caitriona Canning, Tom Robberechts, Andreea Slavescu, Maria S Stoenoiu, Rosario Pascarella, Alexandre Persu","doi":"10.1097/HJH.0000000000004452","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004452","url":null,"abstract":"<p><p>Fibromuscular dysplasia (FMD) has been defined as a nonatherosclerotic and non-inflammatory arterial disease characterized by multifocal or focal stenosis, and often associated with aneurysms, dissections and marked arterial tortuosity. The disease typically affects medium-size arteries including renal, cerebrovascular, visceral and limb arterial beds. By contrast, the prevalence, clinical presentation and, for long, the very existence of aortic FMD have been questioned, and evidence remains scarce and scattered in case reports and small series. This systematic review aims to elucidate the relationship between FMD and aortic involvement, particularly focusing on the incidence, characteristics, and clinical outcomes of aortic disorders in patients with FMD. The literature search identified 24 studies, reporting a total of 34 patients (age range: 19-77 years, 74% women) with documented aortic disorders. Histological confirmation was available in 27 of them (74%). The majority of patients presented with FMD-related symptoms, predominantly hypertension, and a significant portion exhibited multivessel involvement, particularly affecting renal arteries. The findings revealed a predominance of focal aortic stenosis, with some patients exhibiting complications such as aneurysms and dissections. This review emphasizes the necessity for comprehensive screening in patients with FMD to detect concomitant aortic involvement, which could have significant clinical implications. Furthermore, it underscores the need to establish diagnostic criteria for aortic FMD, given the rarity of this condition and the specificities of its clinical presentation. Further research is warranted to explore the genetic underpinnings of aortic FMD and to develop standardized diagnostic approaches for managing patients with aortic involvement in FMD.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous antihypertensive administration before endovascular treatment in large vessel occlusion stroke: a pooled observational analysis of data from three randomized controlled trials.","authors":"Yanjie Huang, Jian Zhang, Xu Xu, Jinfu Ma, Lingyu Zhang, Haoxuan Zhu, Gaoming Li, Linyu Li, Chawen Ding, Fei Gao, Miao Chai, Jiaxing Song, Zhouzhou Peng, Mingrui Zhou","doi":"10.1097/HJH.0000000000004442","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004442","url":null,"abstract":"<p><strong>Objective: </strong>Whether patients suffering large vessel occlusion stroke with hypertension should be treated with intravenous antihypertensives (IV-antihypertensives) prior to endovascular treatment (EVT) remains unclear. We aimed to investigate the association between preprocedural IV-antihypertensives administration and clinical outcomes among this population.</p><p><strong>Methods: </strong>This post hoc pooled observational analysis used data from three randomized controlled trials that investigated interventions other than preprocedural IV-antihypertensive treatment in patients with LVO stroke. Patients were stratified into two groups according to whether they received IV-antihypertensives prior to EVT or not. The primary effectiveness outcome was the distribution of the modified Rankin Scale (mRS) score across the full range at 90 days. Safety outcomes included 90-day mortality, and the incidence of 48-h symptomatic intracranial hemorrhage.</p><p><strong>Results: </strong>A total of 1548 eligible patients were included in the study (non-IV-antihypertensives group, n = 1392; IV-antihypertensives group, n = 156). IV-antihypertensive group was with an unfavorable shift toward higher mRS score at 90 days compared with non-IV-antihypertensive group (adjusted odds ratio 0.70; 95% confidence interval, 0.51-0.96; P = 0.026). In the IV-antihypertensives group, there was a lower rate of successful reperfusion (P < 0.001), and a higher 90-day mortality (P < 0.001). Furthermore, relatively mild baseline stroke severity, smaller infarct core and shorter time of receiving EVT had worse functional outcomes in IV-antihypertensive group (P for interaction >0.05).</p><p><strong>Conclusion: </strong>IV-antihypertensives administration before EVT was associated with poorer 90-day functional outcomes, lower rates of successful reperfusion, and higher 90-day mortality in patients with LVO stroke. Nevertheless, these findings do not establish causality and warrant further confirmation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum fatty acid profile and desaturase activity in hypertensive patients with and without metabolic syndrome.","authors":"Mónica I Cardona-Alvarado, Gertrud Lund, Enrique Ramírez-Chávez, Dalia Rodríguez-Ríos, Silvio Zaina, Elva Pérez-Luque","doi":"10.1097/HJH.0000000000004398","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004398","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a major public health concern. Risk factors for hypertension include dietary factors such as fatty acids (FA), in addition to conditions that contribute to the metabolic syndrome.</p><p><strong>Objectives: </strong>To assess the associations of FA and FA desaturase activities with hypertension and anthropometric/metabolic parameters, and with the presence of metabolic syndrome.</p><p><strong>Methods: </strong>Anthropometric data, circulating FA and a range of metabolic parameters were obtained in fasting normotensive subjects and hypertensive patients (n = 100 and n = 98, respectively) of both sexes. Associations were determined by normotension-to-hypertension comparisons with and without stratification for metabolic syndrome, correlations and logistic regression. To assess reverse causality, sensitivity analyses were performed stratifying by hypertension treatment or excluding recently diagnosed (less than 1 year) patients.</p><p><strong>Results: </strong>Selected FA (C15:0, C17:0, and C20:2ω-6) were consistently associated with low hypertension risk. We also confirmed the association of the FA transC18:1 with high hypertension risk. The direction and strength of those associations persisted after sensitivity analysis. Metabolic syndrome modulated several of the detected associations, as stratifying by metabolic syndrome increased the number of significantly associated FA with hypertension and revealed associations of hypertension with FA desaturases.</p><p><strong>Conclusion: </strong>As C15:0 and C17:0 are mainly of dietary origin, our data underscore the potential for dietary intervention or supplementation in the control of hypertension risk. The FA desaturase Δ9D emerges as a potential target to lower MUFA associated with hypertension risk. Reverse causality driven by treatment or behavioural response to diagnosis played a minor role if any. Our results warrant further studies to assess causality.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}