Journal of Hypertension最新文献

{"title":"Assessing causal relationships between gut microbiotas, metabolites, and pulmonary arterial hypertension through univariate Mendelian randomization study and bioinformatics analysis.","authors":"Dongrui Xu, Hong Liu, Jiankang Yang","doi":"10.1097/HJH.0000000000004003","DOIUrl":"10.1097/HJH.0000000000004003","url":null,"abstract":"<p><strong>Background: </strong>Recent research has linked gut microbiotas and metabolites to the development and progression of pulmonary arterial hypertension (PAH) through the gut-lung axis. However, current studies on the causal relationship between gut microbiotas, gut microbiota derived metabolites, and PAH lack conclusive evidence. This study employed Mendelian randomization and bioinformatics analysis to reveal the possible causal links among them.</p><p><strong>Methods: </strong>Summary statistics of gut microbiotas, metabolites, and PAH were from GWAS. Univariate Mendelian randomization (inverse variance weighted and weighted median), reverse Mendelian randomization, and verification through other PAH GWAS cohorts were used to analyze the possible causal relationships between these gut microbiotas or gut microbiota derived metabolites and PAH. In addition, Cochran's Q statistic, MR-Egger regression intercept, MR-PRESSO global test, and the leave-one-out method were used for the sensitivity analysis. Based on this, we carried out an initial bioinformatics analysis to investigate its potential biological mechanisms.</p><p><strong>Results: </strong>Preliminary screening of the present research revealed four gut microbiotas ( Genus Eubacteriumfissicatenagroup , Genus RuminococcaceaeUCG002, Genus Tyzzerella3, and Genus Sutterella) and one metabolite (taurolithocholate 3-sulfate) correlated with PAH. However, after validation in other PAH GWAS cohorts, only genetically increased Genus Tyzzerella3 (odds ratio: 0.54, 95% confidence interval: 0.37-0.80, P  = 0.0018) correlated with a reduced risk for PAH, a relationship may be related to the keratan sulfate and glycosphingolipid synthesis. No significant heterogeneity, pleiotropy, or reversal causation effect was observed ( P  > 0.05).</p><p><strong>Conclusion: </strong>Our Mendelian randomization analysis establishes a significant correlation between Genus Tyzzerella3 and PAH, positioning it as a prominent protective factor for PAH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1003-1011"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An I-Change approach to understanding exercise determinants among Black individuals with hypertension.","authors":"Donya Nemati, Adrián Noriega de la Colina, Kathy D Wright, Joshua J Joseph, Navin Kaushal","doi":"10.1097/HJH.0000000000003974","DOIUrl":"10.1097/HJH.0000000000003974","url":null,"abstract":"<p><strong>Objective: </strong>Black populations are disproportionately affected by hypertension and are less likely to engage in blood pressure-lowering activities, such as exercise, compared to non-Hispanic White populations. There is a lack of theory-informed approaches to understand how individual and environmental racial disparities impact exercise participation among Black individuals with hypertension. The I-Change Model, an integrated behavior change framework, combines concepts from social and health psychology to explain the interaction between awareness, motivation, and action in adopting and maintaining health behaviors. This study aims to apply an augmented version of the I-Change Model to enhance our understanding of racial disparities in exercise participation.</p><p><strong>Methods: </strong>Individuals with self-reported doctor-diagnosed hypertension ( N  = 370), comprising Black ( n  = 142) and White ( n  = 228) adults who were recruited via an online recruitment platform, completed a survey with validated theoretical constructs at baseline and at 4 weeks. Structural equation modeling with race set as a group variable was used to among both races, intention predicted exercise behavior model path effects.</p><p><strong>Results: </strong>Among both races, intention positively influenced exercise behavior, whereas psychological barriers reduced the likelihood of engaging in the behavior. However, notable racial disparities among Black participants included environmental barriers (e.g., safety, accessibility to a gym) that hindered exercise behavior and affective attitudes that did not facilitate intention.</p><p><strong>Conclusions: </strong>An exercise promotion program that fosters I-Change determinants and creates an accessible, supportive environment would enhance equitable exercise opportunities for Black individuals with hypertension. Additional recommendations for designing such a program are provided.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"961-969"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cardiovascular repercussions in women with previous pregnancies complicated by severe hypertensive disease.","authors":"Renata Gomes Sanches Verardino, Thiago Andrade de Macedo, Sara Rodrigues, Valéria Costa Hong, Fernanda Spadotto Baptista, Maria Rita de Figueiredo Lemos Bortolotto, Rossana Pulcineli Vieira Francisco, Luiz Aparecido Bortolotto","doi":"10.1097/HJH.0000000000003999","DOIUrl":"10.1097/HJH.0000000000003999","url":null,"abstract":"<p><strong>Objective: </strong>To assess the long-term functional and structural repercussions of the heart and vessels in women with a history of severe preeclampsia (PE).</p><p><strong>Methods: </strong>A cross-sectional study conducted at a tertiary hospital involving women 2-5 years postpregnancy, divided into three groups: isolated preeclampsia (de novo PE = 30), superimposed PE and/or chronic hypertension (PEs/HC= 60), and normal gestation (NG = 30). We evaluated age, body mass index (BMI), office systolic (SBP) and diastolic blood pressure (DBP), 24-h ambulatory blood pressure monitoring (ABPM), noninvasive central blood pressure (CBP) by tonometry (sphygmocor), pulse wave velocity (PWV - complior), and echocardiography (ViviDI-GE).</p><p><strong>Results: </strong>Age (38 ± 5 years) and BMI (32.6 ± 6 k/m 2 ) were higher in PEs/HC. Office SBP (mmHg) was higher in de novo PE (124.8 ± 11) and PEs/HC (133.6 ± 19) than NG (114.6 ± 9), and DBP (mmHg) was higher in PEs/HC (87.8 ± 12) than NG (73.3 ± 8) and de novo PE (80.4 ± 12). ABPM showed higher SBP in all periods for PEs/HC than NG and de novo PE. Central SBP was higher in PEs/HC and De novo PE compared to NG and De novo PE. Carotid-femoral PWV (m/s) was higher in PEs/HC (8.1 ± 2) than NG (6.8 ± 1) and de novo PE (7.0 ± 1). Echocardiography revealed increased septal thickness and left atrial diameter in PEs/HC, with a higher left ventricular (LV) mass index in de novo PE and PEs/HC than NG.</p><p><strong>Conclusion: </strong>Women with previous de novo PE have higher office and central blood pressure values and greater ventricular mass compared to those with previous normal pregnancies. The most significant cardiovascular repercussions were observed in women with previous superimposed PE or chronic hypertension during pregnancy.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"951-960"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study.","authors":"Jun Qian, Zhongzheng Zhou, Yiwen Zheng, Shunkang Rong, Yuanqing Yao, Bo Xiong, Weiran Dai, Yun Du, Han Liu, Wei Sha, Dichuan Liu, Changming Deng, Jing Huang","doi":"10.1097/HJH.0000000000004005","DOIUrl":"10.1097/HJH.0000000000004005","url":null,"abstract":"<p><p>This study aimed to evaluate the feasibility and efficacy of a catheter-based ultrasound renal denervation (RDN) system for nerve mapping guided RDN and treatment efficacy verification. A total of five patients were sequentially enrolled. Low-power pulsed ultrasound stimulation was applied at the distal, middle and proximal segments of the renal arteries, in both head-foot and abdomen-back directions. Ultrasound RDN was selectively performed at sites where SBP increased by at least 5 mmHg following stimulation. Supplementary RDN was conducted at any sites exhibiting an SBP increase of at least 5 mmHg after re-stimulation. A total of 60 directional stimulations were applied across 10 renal arteries, with 70% of these directions received ultrasound RDN. The daytime ambulatory SBP decreased from 151 to 130 mmHg after two months. These findings indicate that catheter-based ultrasound renal mapping guided RDN might feasible and could offer a more targeted approach to the RDN procedure.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1083-1085"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr Hassan's letter regarding our article Pharmacotherapy of arterial hypertension in patients with psoriasis.","authors":"Jozef Dodulík","doi":"10.1097/HJH.0000000000004017","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004017","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 6","pages":"1087-1088"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a single session of low- and high-intensity velocity-based resistance exercise on blood pressure in patients with hypertension.","authors":"Luis A Benavides-Roca, Germán Parra, Antonio R Zamunér","doi":"10.1097/HJH.0000000000004015","DOIUrl":"10.1097/HJH.0000000000004015","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of high and low-intensity velocity-based resistance exercise on blood pressure in individuals with hypertension.</p><p><strong>Methodology: </strong>A crossover clinical trial was performed. Thirty-three participants with diagnosis of hypertension took part in the study. Participants underwent two sessions of resistance training: low-intensity, characterized by 12 repetitions and 6 sets at 40% of one-repetition maximum velocity; high-intensity, characterized by 6 repetitions and 6 sets at 80% of one-repetition maximum velocity. A 1-week washout was considered between the sessions. Participants were randomly assigned to exercise intensity at the first session. Blood pressure was measured by an automated device before and immediately after both sessions. 24-h ambulatory blood pressure monitoring (ABPM) was performed after the sessions. Significance level was set at 5%.</p><p><strong>Outcomes: </strong>The results showed that low-intensity resistance exercises significantly decreased systolic (≈5 mmHg), diastolic (≈4 mmHg) and mean arterial blood pressure (≈4 mmHg), which was not observed after the high-intensity exercise. No significant differences were found between exercise sessions for the post 24-h ABPM.</p><p><strong>Conclusion: </strong>Low-intensity resistance exercise was more effective in decreasing blood pressure in patients with hypertension than a high-intensity protocol.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1075-1082"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term event rates, risk factors, and treatment pattern in 1.4 million individuals qualifying for dual blood pressure lowering therapy.","authors":"Antonio Coca, Claudio Borghi, George S Stergiou, Nelly Francoise Ly, Christopher Lee, Aurore Tricotel, Anna Castelo-Branco, Irfan Khan, Jacques Blacher, Mohamed Abdel-Moneim","doi":"10.1097/HJH.0000000000004002","DOIUrl":"10.1097/HJH.0000000000004002","url":null,"abstract":"<p><strong>Objectives: </strong>We assessed rates of cardiovascular events, all-cause death, baseline risk factors, and treatment patterns in a population qualifying for initiation of dual combination blood pressure (BP)-lowering therapy. We also evaluated the association between dual versus monotherapy during follow-up and incidence of cardiovascular events.</p><p><strong>Methods: </strong>This study utilized integrated databases in England: Clinical Practice Research Datalink, Hospital Episode Statistics, and Office for National Statistics. Individuals aged at least 18 years qualifying for dual therapy were identified during 15-year period (2005-2019). The primary endpoint was composite of nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, and cardiovascular death. The secondary endpoint was all-cause death.</p><p><strong>Results: </strong>Total 1 426 079 individuals met selection criteria. The 15-year event rates for the primary and secondary endpoints were 27.1 and 32.6%, respectively. Atherosclerotic cardiovascular disease, diabetes on insulin therapy, heart failure, atrial fibrillation, chronic kidney disease, and advanced age were associated with two to four-fold higher risk of primary and secondary endpoints. The estimated hazard ratio for dual versus monotherapy as a time-varying covariate was 0.82 (95% confidence interval 0.81-0.83) for the primary endpoint. At variance with guidelines, monotherapy was most common treatment pattern over 5-year follow-up.</p><p><strong>Conclusion: </strong>Baseline characteristics conveying a multifold higher risk for cardiovascular events and all-cause death mostly represented nonmodifiable risk factors. Treatment with dual therapy as compared to monotherapy was associated with reduction in cardiovascular events. Monotherapy remained most common BP-lowering treatment indicating substantial opportunity for risk reduction by treatment intensification.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"993-1002"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of antihypertensive therapy in psoriasis: limitations and future directions.","authors":"Ibrahim Nagmeldin Hassan","doi":"10.1097/HJH.0000000000004016","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004016","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 6","pages":"1086"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell adhesion molecules and incident hypertension in black and white adults: the REGARDS study.","authors":"Tyler Harkness, Katherine Wilkinson, Ying K Loo, Virginia J Howard, Mary Cushman, Neil A Zakai, Katharine L Cheung, Suzanne E Judd, Timothy B Plante","doi":"10.1097/HJH.0000000000004004","DOIUrl":"10.1097/HJH.0000000000004004","url":null,"abstract":"<p><strong>Background: </strong>Higher C-reactive protein-quantified inflammation associates with greater incident hypertension risk. E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) are cell adhesion molecules that aid leukocyte adhesion during inflammation. Their association with incident hypertension is unclear.</p><p><strong>Methods: </strong>REGARDS enrolled 30 239 Black and White US adults aged ≥45 years from across the contiguous United States in 2003-2007, with a second exam in 2013-2016. The Biomarkers as Mediators of Racial Disparities in Risk Factors (BioMedioR) study included 4400 REGARDS participants who attended both exams. We excluded participants with hypertension or missing biomarkers at baseline. Hypertension used a 140/90 mmHg threshold or self-reported use of blood pressure (BP) lowering medications. Modified Poisson regression estimated relative risk (RR) of incident hypertension by tertile of baseline E-Selectin, ICAM-1, and VCAM-1.</p><p><strong>Results: </strong>Among 1879 nonhypertensive participants (mean [SD] age 62 [8] years, 25% Black race, 55% women) with 9 years median follow up, 36% developed hypertension. E-selectin and ICAM-1 were higher among Black participants; VCAM-1 was higher among White participants. Higher E-selectin was associated with greater risk of incident hypertension among White but not Black adults in some models (e.g., minimally adjusted: RR 1.27; 95% confidence interval (CI) 1.04-1.44 comparing tertile 3 vs. 1) ICAM-1 was associated with greater hypertension risk in only an unadjusted model.</p><p><strong>Conclusion: </strong>In a prospective study of Black and White US adults, E-selectin was associated with incident hypertension among White adults and ICAM-1 in White and Black adults in partially or unadjusted models. Modification of E-selectin might be tested to lower risk of hypertension development.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1012-1020"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing the paradigm of long-term blood pressure control: a systematic review of novel therapies.","authors":"Sonali R Gnanenthiran, Sabrina Delgado, Katrina M Mirabito Colafella, Markus P Schlaich, Aletta E Schutte, Anthony Rodgers","doi":"10.1097/HJH.0000000000003984","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003984","url":null,"abstract":"<p><p>Novel drug and device therapies have the potential to achieve long-term control of blood pressure (BP) and thereby overcome the barriers of nonadherence and undertreatment. We propose that ideal BP lowering therapy should meet six key criteria: (i) achieve a clinically relevant BP reduction; (ii) durable BP reduction; (iii) be well tolerated; (iv) have the ability to be safely combined with other BP lowering treatments; (v) have high patient acceptability and (vi) be cost-effective and simple to use to maximize scalability. In this paper, we systematically review emerging solutions for long-term control of BP including antibody-based therapies, sRNA therapies, and DNA-based gene editing which target the renin angiotensin system, and implant therapies, and interventional approaches (renal denervation and baroreceptor activation therapies). These novel therapies may substantially complement and, in some settings, even replace current antihypertensive therapies. Implementation will require significant progress in overcoming technological-, systems-, prescriber- and patient-level barriers.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 6","pages":"917-928"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}