Grace Oscullo, Martino F Pengo, Jose Daniel Gómez-Olivas, Carolina Lombardi, Gianfranco Parati, Miguel Angel Martinez-Garcia
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引用次数: 0
Abstract
Refractory hypertension (RfH) is the most difficult-to-control form of hypertension and carries the highest cardiovascular risk. It is estimated to account for 0.5-1% of all forms of hypertension. Sleep apnea syndrome (OSA), defined as the repeated partial or complete interruption of the airway flow during sleep, is highly prevalent, with almost one billion people worldwide suffering from it. Both diseases share a pathophysiological mechanism: the hyperactivation of the sympathetic nervous system. In recent years, a clinical relationship between RfH and OSA has been demonstrated. 80-90% of patients with RfH suffer from OSA, which could partly explain the refractoriness to treatment. Treatment of OSA with continuous positive airway pressure (CPAP) significantly reduces blood pressure by 8-10 mmHg in patients with RfH.
期刊介绍：
The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.
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