Journal of Hypertension最新文献

{"title":"Hypertension in autoimmune rheumatic diseases: progress made, gaps remain.","authors":"Gisele Facholi Bomfim, Michael J Ryan, Leonardo Bonilha, Cameron G McCarthy, Camilla F Wenceslau","doi":"10.1097/HJH.0000000000004344","DOIUrl":"10.1097/HJH.0000000000004344","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1325-1326"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comment: Limited public understanding of the risk factors and complications of hypertension.","authors":"Mingjuan Zeng, Sonali R Gnanenthiran, David K E Chan, Ruth Griffiths, Aletta E Schutte","doi":"10.1097/HJH.0000000000004346","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004346","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1471-1472"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and skeletal fragility: time to add bone to the target-organ list?","authors":"Carmine Zoccali, Francesca Mallamaci","doi":"10.1097/HJH.0000000000004350","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004350","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1322-1324"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of night shift work on vascular function in healthy adult workers.","authors":"Hiroyasu Murata, Ai Hirasawa, Ayumu Sakurai, Daichi Takano, Shotaro Saito, Marina Fukuie, Rina Suzuki, Masayoshi Horino, Shinya Matsushima, Shigeki Shibata","doi":"10.1097/HJH.0000000000004336","DOIUrl":"10.1097/HJH.0000000000004336","url":null,"abstract":"<p><strong>Background: </strong>Night shift work (NSW) is associated with increased cardiovascular risk, but its impact on vascular function and the role of lifestyle factors in healthy individuals remain unclear. We aimed to compare vascular function between NSW and day workers (DW) and to examine associations with objectively measured lifestyle behaviors.</p><p><strong>Methods: </strong>In this cross-sectional study, 40 healthy adults (20 DW, 20 NSW) underwent assessments of flow-mediated dilation (FMD), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI). Physical activity and sleep status were objectively measured using triaxial accelerometry for 7 consecutive days. Group comparisons and correlation analyses were conducted to evaluate the effects of NSW and its association with lifestyle factors.</p><p><strong>Results: </strong>FMD was significantly lower in the NSW group than in the DW group (4.0% vs. 7.0%, P  < 0.01), while baPWV and ABI showed no between-group differences. In the overall cohort, FMD was positively correlated with time in bed, total sleep time, and sleep efficiency, and negatively correlated with nocturnal awakening. Subgroup analysis revealed that FMD was associated with sleep quality in DW and with physical activity patterns in NSW.</p><p><strong>Conclusions: </strong>Chronic night shift work is associated with impaired endothelial function in healthy adults, potentially driven by disrupted sleep and reduced physical activity. Early assessment using FMD and targeted behavioral interventions may help preserve vascular health among shift workers.</p><p><strong>Lay summary: </strong>This study shows that healthy adults who regularly work night shifts have poorer blood vessel function than people who only work daytime hours, and that sleep and physical activity patterns may help explain this difference.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1345-1353"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of participants with a disproportionate degree of hypertension-mediated organ damage: the Maastricht study.","authors":"Dellaneira Setjiadi, Christian Delles, Abraham A Kroon, Koen Ressink, Otto Bekers, Steven J R Meex, Sebastian Köhler, Jeroen P Kooman, Jacobus F A Jansen, Hans-Peter Brunner-La Rocca, Anke Wesselius, Alfons J H M Houben, Marleen M J van Greevenbroek","doi":"10.1097/HJH.0000000000004265","DOIUrl":"10.1097/HJH.0000000000004265","url":null,"abstract":"<p><strong>Background: </strong>Although there is a well established link between blood pressure (BP) levels and the severity of hypertension-mediated organ damage (HMOD), some patients with hypertension exhibit a disproportionate degree of HMOD relative to their BP.</p><p><strong>Objective: </strong>This study aims to define disproportionate degrees, relative to blood pressure, of left ventricular hypertrophy (LVH) measured by Sokolow-Lyon (SL) index and of arterial stiffness measured by carotid-femoral pulse wave velocity (PWV), and to assess the sex differences and characteristics of individuals with such disproportional SL index and PWV.</p><p><strong>Methods: </strong>SL index was analysed in 6487 participants of The Maastricht Study [50.9% men; 23.7% type 2 diabetes mellitus (T2DM)]. PWV was analysed in 6239 participants (51.3% men; 23.5% T2DM). The residuals of linear regression models for the relationship between SL index or PWV and 24 h mean arterial pressure (MAP) was used to define participants with disproportional SL index and PWV, respectively. Individuals with higher-than-expected (>90th percentile of the residuals) and lower-than-expected (<10th percentile) of SL index or PWV were defined as subclinical HMOD. A multinomial regression analysis was conducted to identify the clinical characteristics associated with subclinical HMOD.</p><p><strong>Results: </strong>Males and females with higher SL index than expected based on their 24 h MAP, were older, had a higher BMI and were more often living with type 2 diabetes in comparison to those in the as-expected and lower-than-expected groups. In line, men who are living with diabetes are 34% less likely to be in the group with lower-than-expected SL index while women living with prediabetes and type 2 diabetes are 40% more likely to be in the group with higher-than-expected SL index. Likewise, males and females with higher-than-expected PWV were older and more often living with type 2 diabetes than those in the as-expected and lower-than-expected groups.</p><p><strong>Conclusions: </strong>Persons who are older, or living with obesity and/or T2D are more likely to have subclinical HMOD, than would be expected based on their prevailing level of BP. Therefore, these clinical determinants would result in higher-than-expected HMOD. Treating those with overweight and obesity with prediabetes and diabetes more aggressively will likely reduce subclinical HMOD.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1329-1336"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Neurofibromatosis 2 alleviates ferroptosis and fibrosis in the aortas of spontaneously hypertensive rats through the Yes-associated protein pathway.","authors":"","doi":"10.1097/HJH.0000000000004349","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004349","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1473-1474"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephron deficit as susceptibility, not determinism.","authors":"Nobuo Tsuboi","doi":"10.1097/HJH.0000000000004342","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004342","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1469-1470"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased 24-h blood pressure and arterial stiffness in young adults with childhood-onset type 1 diabetes: the Norwegian Atherosclerosis and Childhood Diabetes study.","authors":"Aida Simeunovic, Cathrine Brunborg, Martin Heier, Tore Julsrud Berg, Knut Dahl-Jørgensen, Hanna Dis Margeirsdottir","doi":"10.1097/HJH.0000000000004338","DOIUrl":"10.1097/HJH.0000000000004338","url":null,"abstract":"<p><strong>Objective: </strong>Individuals with type 1 diabetes (T1D) have increased mortality from cardiovascular disease (CVD) compared to general population, where hypertension is a major risk factor. The aim of this study was to evaluate blood pressure (BP) and arterial stiffness in young adults with childhood-onset T1D compared to healthy control subjects.</p><p><strong>Methods: </strong>The atherosclerosis and childhood diabetes (ACD) study is a prospective population-based cohort study, with follow-up every fifth year on early atherosclerosis development and other cardiovascular risk factors in childhood-onset T1D compared to healthy controls. At baseline the cohort was recruited among children with T1D in a defined health-region in Norway along with their friends as healthy control subjects. The original T1D cohort was found to be representative of all children with T1D in Norway at that time. At the 10-year follow-up a cross-sectional analysis of 24-h ambulatory blood pressure measurements (ABPM), including arterial stiffness, was performed, along with an assessment of other CVD risk factors.</p><p><strong>Results: </strong>One hundred and twenty-three participants were included in the analysis (T1D n  = 82, controls n  = 41). The T1D group had mean ± SD age of 24 ± 3 years, diabetes duration of 15 ± 4 years and present HbA1c of 64 ± 14 mmol/mol (8.0 ± 1.3%). None of the T1D participants had previously known hypertension or were on antihypertensive treatment. Females with T1D had significantly higher mean weight, BMI, waist circumference, LDL-cholesterol, and apolipoprotein B than female controls. In females, almost all parameters of ABPM were significantly increased compared to their controls, whereas in males only nighttime blood pressure (BP) was significantly increased compared to controls. In the (stage 2) hypertensive group with T1D, LDL-c (3.1 ± 0.08; ρ = 0.038) was significantly increased. Arterial stiffness was significantly increased in the T1D group (24-h PWV was 8.0 ± 1.0 m/s vs. 7.2 ± 0.6 m/s; ρ  = 0.011) compared to controls.</p><p><strong>Conclusion: </strong>Young adults with childhood-onset T1D had significantly increased BP and arterial stiffness compared to controls, especially females.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1374-1381"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting public understanding of hypertension: methodological considerations and future directions.","authors":"Ahmad Shafi Antar, Asia Sharifi","doi":"10.1097/HJH.0000000000004331","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004331","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"44 8","pages":"1466-1467"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity interval training is associated with improvements in ambulatory blood pressure, arterial stiffness, and gut-derived metabolites in adults with hypertension.","authors":"Alireza Ghardashi Afousi, Maryam Asvadi Fard, Aida Sabouri","doi":"10.1097/HJH.0000000000004337","DOIUrl":"10.1097/HJH.0000000000004337","url":null,"abstract":"<p><strong>Background: </strong>Gut microbiota-derived metabolites, including trimethylamine N-oxide (TMAO) and short-chain fatty acids (SCFAs), are associated with vascular function and blood pressure (BP) regulation. However, whether high-intensity interval training (HIIT) is accompanied by coordinated changes in these metabolites, along with improvements in ambulatory BP (ABP), and arterial stiffness in adults with hypertension (HTN), remains unclear.</p><p><strong>Methods: </strong>In this 12-week randomized controlled trial (RCT), 60 adults with HTN (age 60.1 ± 6.1 years) were allocated to the HIIT or CONTROL group. HIIT consisted of 10-15 cycling intervals (1 min at 85-90% of heart rate reserve) interspersed with 1 min of active recovery (50-55% of heart rate reserve), performed three times per week. 24 h ABP, carotid-femoral pulse wave velocity (cfPWV), and plasma concentrations of TMAO and SCFAs were assessed before and after intervention.</p><p><strong>Results: </strong>Compared with CONTROL, HIIT was associated with greater reductions in office BP (6.9/3.1 mmHg, P  < 0.001), 24 h systolic and diastolic ABP (6.1/3.5 mmHg, P  < 0.001) and cfPWV (225.7 ± 41.8 cm/s, P  < 0.001). Plasma TMAO concentrations decreased following HIIT (1.41 ± 0.66 μmol/l, P  = 0.001), while acetate (5.72 ± 2.27 μmol/l), propionate (0.76 ± 0.36 μmol/l), and butyrate (0.65 ± 0.21 μmol/l) increased ( Ps  = 0.001). Reductions in systolic ABP ( r  = 0.780, P  < 0.001), diastolic ABP ( r  = 0.713, P  < 0.001), and cfPWV ( r  = 0.542, P  = 0.002) were positively associated with decreases in TMAO and inversely associated with changes in SCFAs levels.</p><p><strong>Conclusion: </strong>In adults with HTN, HIIT was associated with improvements in ABP, arterial stiffness, and gut microbiota-derived metabolites level. These findings support an integrated relationship between exercise-related metabolic adaptation and vascular function, highlighting the potential relevance of the gut-vascular axis in BP regulation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1362-1373"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}