Journal of Hypertension最新文献_第10页

Association of visit-to-visit blood pressure variability with kidney disease progression and cardiovascular outcomes in the chronic renal insufficiency cohort (CRIC). 慢性肾功能不全队列（CRIC）中，每次就诊血压变异性与肾脏疾病进展和心血管结局的关系

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004410

Rushelle L Byfield, Rachel Zhang, Alavi Hossain, Debbie L Cohen, Raymond R Townsend, Ian M Kronish, Daichi Shimbo, Jordana B Cohen

{"title":"Association of visit-to-visit blood pressure variability with kidney disease progression and cardiovascular outcomes in the chronic renal insufficiency cohort (CRIC).","authors":"Rushelle L Byfield, Rachel Zhang, Alavi Hossain, Debbie L Cohen, Raymond R Townsend, Ian M Kronish, Daichi Shimbo, Jordana B Cohen","doi":"10.1097/HJH.0000000000004410","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004410","url":null,"abstract":"Background: Visit-to-visit variability (VVV) of blood pressure (BP) has been linked to adverse cardiovascular and kidney outcomes in various populations, but results in those with chronic kidney disease (CKD) have been inconsistent.Methods: We evaluated VVV in Chronic Renal Insufficiency Cohort (CRIC) participants, using the coefficient of variation (CoV = standard deviation of SBP/mean SBP) calculated from BP measurements obtained at baseline visit through year 5 of the study. Cox proportional hazards models were used to assess the association of CoV with a composite cardiovascular outcome (myocardial infarction, stroke, peripheral artery disease, heart failure) and a composite kidney outcome (50% reduction in estimated glomerular filtration rate or end-stage kidney disease).Results: Among 3891 participants (44% women, mean age 63 ± 10 years, mean CoV 10.3 ± 5.2%), 757 cardiovascular and 920 kidney events occurred during a median follow-up of 5.4 and 4.5 years, respectively. In unadjusted analyses, the upper tertile of CoV was associated with increased risk of both cardiovascular [hazard ratio 2.04, 95% confidence interval (CI) 1.70-2.43] and kidney outcomes (hazard ratio 1.62, 95% CI 1.38-1.89) compared to the lowest tertile. However, after adjustment for clinical and sociodemographic factors, higher CoV was significantly associated with cardiovascular outcomes (adjusted hazard ratio 1.25, 95% CI 1.04-1.52) but not kidney outcomes (adjusted hazard ratio 0.95, 95% CI 0.80-1.15).Conclusion: In this large CKD cohort, higher visit-to-visit BP variability was independently linked to adverse cardiovascular, but not kidney, outcomes.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term treatment with soluble guanylyl cyclase stimulator BAY41-8543 abolishes malignant hypertension-related mortality and attenuates organ damage: studies in Ren-2 transgenic rats treated with L-NAME. 长期服用可溶性胍基环化酶刺激剂BAY41-8543可消除恶性高血压相关死亡率并减轻器官损害：用L-NAME治疗Ren-2转基因大鼠的研究

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004422

Martina Hüttl, Matúš Miklovič, Petra Škaroupková, Zdenka Vaňourková, Soňa Kikerlová, Janusz Sadowski, Michal Šnorek, Peter Sandner, Luděk Červenka

{"title":"Long-term treatment with soluble guanylyl cyclase stimulator BAY41-8543 abolishes malignant hypertension-related mortality and attenuates organ damage: studies in Ren-2 transgenic rats treated with L-NAME.","authors":"Martina Hüttl, Matúš Miklovič, Petra Škaroupková, Zdenka Vaňourková, Soňa Kikerlová, Janusz Sadowski, Michal Šnorek, Peter Sandner, Luděk Červenka","doi":"10.1097/HJH.0000000000004422","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004422","url":null,"abstract":"Objective: Malignant hypertension (MH) remains a life-threatening condition and new pharmacological strategies and drugs with potential new mode of actions are currently investigated. The aim of the present study was to evaluate the effects of nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) stimulator on the long-term MH-related mortality and morbidity.Methods: As a model of MH, Ren-2 transgenic rats (TGR) treated with nonspecific NO synthase inhibitor, [Nω-nitro-l-arginine methyl ester - (L-NAME)], was used. Systolic blood pressure (SBP) was measured by tail-cuff method. The treatment with sGC stimulator, BAY41-8543, was started 3 days before administration of L-NAME. The follow-up period was 120days after L-NAME administration.Results: Untreated TGR + L-NAME rats developed MH (SBP on day +10 was 207 ± 4 mmHg) associated with development of marked albuminuria and high mortality (median survival rate 8 days). The treatment with sGC stimulator BAY41-8543 completely abolished MH-related mortality in TGR receiving L-NAME (all animals survived until end of the study) and prevented rises in SBP and development of albuminuria.Conclusion: The treatment with sGC stimulator BAY41-8543 provided long-term protection against MH-related mortality and morbidity. On the whole, these results suggest that pharmacological targeting NO/sGC pathway should be considered in attempts to develop new pharmacological strategies for treatment of MH.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The MDS-arterial stiffness link: interpreting what remains unmeasured. mds与动脉僵硬度的联系：解释仍未测量的东西。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004334

Almas Gul, Ramsha Gul

引用次数: 0

Outcomes of renal angioplasty for fibromuscular dysplasia in Asian vs. white patients: a systematic review and meta-analysis. 肾脏血管成形术治疗纤维肌肉发育不良的亚洲和白人患者的结果：系统回顾和荟萃分析。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-05-20 DOI: 10.1097/HJH.0000000000004354

Weiwei Wang, Tom Robberechts, Jianzhong Xu, Tomotaka Fujimoto, Anne-Catherine Pouleur, David Vancraeynest, Nada Kanaan, Jiguang Wang, Kan Zen, Maria Simona Stoenoiu, Alexandre Persu

{"title":"Outcomes of renal angioplasty for fibromuscular dysplasia in Asian vs. white patients: a systematic review and meta-analysis.","authors":"Weiwei Wang, Tom Robberechts, Jianzhong Xu, Tomotaka Fujimoto, Anne-Catherine Pouleur, David Vancraeynest, Nada Kanaan, Jiguang Wang, Kan Zen, Maria Simona Stoenoiu, Alexandre Persu","doi":"10.1097/HJH.0000000000004354","DOIUrl":"10.1097/HJH.0000000000004354","url":null,"abstract":"Percutaneous transluminal renal angioplasty (PTRA) is the first-line treatment for fibromuscular dysplasia (FMD)-related renal artery stenosis. Previous meta-analyses were predominantly based on white populations. We updated the meta-analysis to include Asian data and allow ethnicity-specific comparisons. Seven databases were systematically searched for clinical studies published since 2000 reporting PTRA outcomes in FMD. Data were pooled using random-effects models. Twenty-nine studies (1470 patients) were included: 15 Asian ( n = 823) and 14 white ( n = 647). Hypertension cure was significantly higher in Asians (40 vs. 17%; P < 0.001). Cure or improvement tended to be higher in Asians (90 vs. 78%; P = 0.08). SBP reduction tended to be greater (-33 vs. -23mmHg; P = 0.08), and DBP reduction was significantly greater in Asians (-21 vs. -11 mmHg; P = 0.016). Reduction in antihypertensive drugs (-1.1 vs. -0.8; P = 0.10), technical success (97 vs. 99%; P = 0.25), and restenosis (20 vs. 19%; P = 0.96) were similar. Overall reported periprocedural complications were more frequent in whites (12 vs. 1%; P = 0.01), with no deaths in either group. In meta-regression, younger age and a higher proportion of men were associated with hypertension cure in univariable analyses. However, when both variables were included in a multivariable model, only age remained independently predictive. PTRA shows comparable safety and procedural success in Asian and white patients with renal FMD, while BP responses are more favorable in Asians. Age independently predicts hypertension cure, underscoring the importance of early diagnosis and timely intervention.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1285-1294"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-chain acyl-CoA dehydrogenase: a novel and promising therapeutic target for heart failure via modulation of mitochondrial fatty acid oxidation. 短链酰基辅酶a脱氢酶：通过线粒体脂肪酸氧化调节心力衰竭的一个新的和有前途的治疗靶点。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-05-07 DOI: 10.1097/HJH.0000000000004345

Yingqin Liao, Jingyun Feng, Chunyu Chen, Yaxin Duan, Zhonghong Li, Yongshao Su, Jieyu Xing, Haiyun Chen, Guixiang Wang, Sigui Zhou

{"title":"Short-chain acyl-CoA dehydrogenase: a novel and promising therapeutic target for heart failure via modulation of mitochondrial fatty acid oxidation.","authors":"Yingqin Liao, Jingyun Feng, Chunyu Chen, Yaxin Duan, Zhonghong Li, Yongshao Su, Jieyu Xing, Haiyun Chen, Guixiang Wang, Sigui Zhou","doi":"10.1097/HJH.0000000000004345","DOIUrl":"10.1097/HJH.0000000000004345","url":null,"abstract":"Objective: Heart failure is a major global health problem with high morbidity and mortality. Dysregulated fatty acid oxidation (FAO) appears to be an important therapeutic target for directly improving cardiac function. Short-chain acyl-CoA dehydrogenase (SCAD) is a key enzyme in FAO. This study aimed to elucidate the role of SCAD in heart failure.Methods: Left anterior descending (LAD) coronary artery ligation in rats was used as an acute heart failure model, whereas aged spontaneously hypertensive rats (SHRs, 20 months old) served as a chronic heart failure model. We generated conventional SCAD knockout (KO) mice to evaluate the role of SCAD in heart failure. Additionally, adenovirus-mediated SCAD overexpression was employed. Heart sections from patients with heart failure were analyzed for SCAD expression.Results: SCAD expression was downregulated in chronic heart failure in aged SHRs. Subsequent experiments showed that aged SCAD-deficient mice (2 years old) developed spontaneous heart failure. Moreover, SCAD KO markedly exacerbated heart failure in transverse aortic constriction-operated mice. Conversely, adenovirus-mediated SCAD overexpression suppressed tert-butyl hydroperoxide-induced cardiomyocyte apoptosis in vitro and protected the heart against LAD ligation-induced heart failure after myocardial infarction in rats. Similarly, SCAD expression was decreased in the hearts of patients with heart failure.Conclusion: SCAD has a negative regulatory effect on heart failure and may represent a novel therapeutic target.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1382-1398"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update from the National Hypertension Taskforce of Australia: prevalence, treatment and control rates of hypertension between 2022 and 2024 - implications and future directions. 来自澳大利亚国家高血压工作组的最新信息：2022年至2024年间高血压的患病率、治疗和控制率——含义和未来方向。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-05-27 DOI: 10.1097/HJH.0000000000004358

Amelie H Ohlrogge, Xiaoyue Xu, Andrew Goodman, Garry Jennings, Lisa Murphy, Mark R Nelson, James E Sharman, Rob Tassie, Markus P Schlaich, Aletta E Schutte

{"title":"Update from the National Hypertension Taskforce of Australia: prevalence, treatment and control rates of hypertension between 2022 and 2024 - implications and future directions.","authors":"Amelie H Ohlrogge, Xiaoyue Xu, Andrew Goodman, Garry Jennings, Lisa Murphy, Mark R Nelson, James E Sharman, Rob Tassie, Markus P Schlaich, Aletta E Schutte","doi":"10.1097/HJH.0000000000004358","DOIUrl":"10.1097/HJH.0000000000004358","url":null,"abstract":"High blood pressure is the dominant risk factor for cardiovascular diseases and death in Australia. The blood pressure control rate in Australia was reported at 32% based on 2017-2018 data, which is substantially lower than other high-income countries. New results from the National Health Survey show an improvement of the crude control rate to 39.6% in the years 2022-2023, though changes in methodology need to be considered in the interpretation. Hypertension prevalence has increased from 33.7 to 39.4%. The prevalence and control rates vary strongly across diverse population groups. The age-standardized prevalence among First Nations peoples is higher than in the general population (37.8 versus 35%), and age-standardized blood pressure control rates are lower (22.2 versus 31.1%). Younger individuals and those in socioeconomically disadvantaged areas have substantially lower control rates, highlighting the need for greater equity to achieve the National Hypertension Taskforce's goal of 70% blood pressure control by 2030.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1457-1461"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension in autoimmune rheumatic diseases: progress made, gaps remain. 自身免疫性风湿病高血压：取得进展，仍有差距。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004344

Gisele Facholi Bomfim, Michael J Ryan, Leonardo Bonilha, Cameron G McCarthy, Camilla F Wenceslau

引用次数: 0

Reply to comment: Limited public understanding of the risk factors and complications of hypertension. 回复评论：公众对高血压危险因素和并发症的了解有限。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004346

Mingjuan Zeng, Sonali R Gnanenthiran, David K E Chan, Ruth Griffiths, Aletta E Schutte

引用次数: 0

Hypertension and skeletal fragility: time to add bone to the target-organ list? 高血压和骨骼脆弱：是时候将骨骼加入目标器官列表了？

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004350

Carmine Zoccali, Francesca Mallamaci

引用次数: 0

Impact of night shift work on vascular function in healthy adult workers. 夜班对健康成年工人血管功能的影响。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-05-14 DOI: 10.1097/HJH.0000000000004336

Hiroyasu Murata, Ai Hirasawa, Ayumu Sakurai, Daichi Takano, Shotaro Saito, Marina Fukuie, Rina Suzuki, Masayoshi Horino, Shinya Matsushima, Shigeki Shibata

{"title":"Impact of night shift work on vascular function in healthy adult workers.","authors":"Hiroyasu Murata, Ai Hirasawa, Ayumu Sakurai, Daichi Takano, Shotaro Saito, Marina Fukuie, Rina Suzuki, Masayoshi Horino, Shinya Matsushima, Shigeki Shibata","doi":"10.1097/HJH.0000000000004336","DOIUrl":"10.1097/HJH.0000000000004336","url":null,"abstract":"Background: Night shift work (NSW) is associated with increased cardiovascular risk, but its impact on vascular function and the role of lifestyle factors in healthy individuals remain unclear. We aimed to compare vascular function between NSW and day workers (DW) and to examine associations with objectively measured lifestyle behaviors.Methods: In this cross-sectional study, 40 healthy adults (20 DW, 20 NSW) underwent assessments of flow-mediated dilation (FMD), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI). Physical activity and sleep status were objectively measured using triaxial accelerometry for 7 consecutive days. Group comparisons and correlation analyses were conducted to evaluate the effects of NSW and its association with lifestyle factors.Results: FMD was significantly lower in the NSW group than in the DW group (4.0% vs. 7.0%, P < 0.01), while baPWV and ABI showed no between-group differences. In the overall cohort, FMD was positively correlated with time in bed, total sleep time, and sleep efficiency, and negatively correlated with nocturnal awakening. Subgroup analysis revealed that FMD was associated with sleep quality in DW and with physical activity patterns in NSW.Conclusions: Chronic night shift work is associated with impaired endothelial function in healthy adults, potentially driven by disrupted sleep and reduced physical activity. Early assessment using FMD and targeted behavioral interventions may help preserve vascular health among shift workers.Lay summary: This study shows that healthy adults who regularly work night shifts have poorer blood vessel function than people who only work daytime hours, and that sleep and physical activity patterns may help explain this difference.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1345-1353"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0