Journal of Hypertension最新文献

{"title":"Predicting blood pressure response to renal denervation based on a new approach.","authors":"Venera Bytyqi, Dennis Kannenkeril, Kristina Striepe, Agnes Bosch, Marina V Karg, Axel Schmid, Mario Schiffer, Michael Uder, Roland E Schmieder","doi":"10.1097/HJH.0000000000003918","DOIUrl":"10.1097/HJH.0000000000003918","url":null,"abstract":"<p><strong>Background: </strong>Identifying predictors of blood pressure (BP) response to renal denervation (RDN) is crucial for patient selection. According to Wilder's principle, baseline BP predicts BP change after any antihypertensive intervention. Thus, any observed BP change after RDN is the sum of the BP change depending on the baseline BP and the specific BP reduction due to RDN. Based on this concept, we propose a new definition of BP responders.</p><p><strong>Methods: </strong>In our center, 148 patients with uncontrolled hypertension underwent RDN, and 24-h ambulatory BP (ABP) was measured at baseline, and 6 months after the procedure. The decrease in 24-h systolic BP (SBP) correlated with baseline SBP ( P  = <0.001, r  = -0.374). We determined the RDN-specific effect by subtracting the predicted SBP decrease from the observed SBP decrease. The cohort was divided into RDN responders, neutral responders, and nonresponders.</p><p><strong>Results: </strong>Our study population had a mean age of 59 ± 10.4 years and was 74% male. The RDN-specific (residual) 24-h ABP decreased by -14.9 ± 6.3/-8.2 ± 3.8 mmHg (responder group), 1.0 ± 3.2/0.2 ± 1.9 mmHg (neutral group), and 14.2 ± 10.4/8.3 ± 3.9 mmHg (nonresponder group) 6 months after RDN. Responders had fewer antihypertensive medications ( P  = 0.018), higher baseline office heart rate (HR) ( P  = 0.019), higher 24-h ambulatory HR ( P  = 0.003), lower BMI ( P  < 0.038), and absence of type 2 diabetes (T2D) ( P  = 0.020).</p><p><strong>Conclusion: </strong>Our definition of BP responders to RDN separates baseline BP-related changes from RDN-specific changes. Positive predictors for BP response to RDN include low BMI, fewer antihypertensive medications, high baseline office HR, high 24-h ambulatory HR, and absence of T2D.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"413-419"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of hypertension after kidney transplantation is associated with improved kidney transplant outcomes: a nationwide cohort study.","authors":"Kyungho Lee, Bong-Sung Kim, Junseok Jeon, Dong Wook Shin, Jung Eun Lee, Wooseong Huh, Kyung-Do Han, Hye Ryoun Jang","doi":"10.1097/HJH.0000000000003938","DOIUrl":"10.1097/HJH.0000000000003938","url":null,"abstract":"<p><strong>Objectives: </strong>Patients with advanced chronic kidney disease suffer from hypertension, and kidney transplantation (KT) has potential to induce hypertension resolution. We hypothesized that hypertension resolution after KT is associated with better KT outcomes.</p><p><strong>Methods: </strong>We identified KT recipients (2006-2015) who had pretransplant hypertension. They were categorized into two groups based on their hypertension status after KT: persistent vs. resolved hypertension, using data from the Korea National Health Insurance System. Cox proportional hazard analyses were performed to assess the risk of graft failure and mortality, adjusting for various clinical factors.</p><p><strong>Results: </strong>Among 11 317 KT recipients with pretransplant hypertension, 7269 (64%) remained hypertensive, while 4048 (36%) experienced hypertension resolution. Recipients with resolved hypertension exhibited a lower prevalence of delayed graft function and major comorbidities, including diabetes, ischemic heart disease, and stroke. Graft failure and mortality rates were significantly lower in resolved hypertension group. After adjusting for multiple covariates, hazard ratios of resolved hypertension were 0.61 (95% confidence interval 0.52-0.72) for graft failure and 0.68 (0.56-0.81) for all-cause mortality.</p><p><strong>Conclusions: </strong>A significant proportion of patients experienced hypertension resolution after KT, which is associated with improved graft and overall survival. The post-KT hypertension resolution can be used as a prognostic indicator for predicting better KT outcomes.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"529-537"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative balance score with blood pressure, all-cause and cardiovascular disease mortality among hypertensive patients: a prospective study.","authors":"Menghan Yuan, Yingyue Zhang, Nina Zuo, Haoying Lei, Xuming Zhao, Yong Xu","doi":"10.1097/HJH.0000000000003931","DOIUrl":"10.1097/HJH.0000000000003931","url":null,"abstract":"<p><strong>Objective: </strong>The oxidative balance score (OBS) has emerged as a novel marker for assessing oxidative stress status. This study aimed to investigate the association of OBS with systolic blood pressure (SBP), diastolic blood pressure (DBP), all-cause, and cardiovascular disease mortality in hypertensive patients.</p><p><strong>Methods: </strong>We conducted an analysis of data from 7602 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Multiple linear regression, Cox proportional hazards models, Kaplan-Meier survival curves, restricted cubic spline, and subgroup analysis were used to examine the association between OBS and SBP, DBP, estimated pulse wave velocity (ePWV), and mortality risk.</p><p><strong>Results: </strong>The results showed that individuals in the highest OBS quartile (27 ≤ OBS ≤ 40) had a significant 2.41 mmHg reduction in SBP compared to the lowest quartile (5 ≤ OBS ≤ 15) ( Ptrend  < 0.001). Compared to the lowest quartile, individuals in the highest OBS quartile had a 29% lower risk of all-cause mortality and a 44% lower risk of cardiovascular disease mortality ( Ptrend  < 0.001). This inverse association persisted irrespective of antihypertensive medication use. OBS is inversely associated with SBP, all-cause, and cardiovascular disease mortality in hypertensive patients.</p><p><strong>Conclusion: </strong>This finding provides new evidence and suggestions for those with poor blood pressure control and low OBS (<15) to adjust their diet and lifestyle reasonably.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"492-503"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation interest and completion of home blood pressure measurements with mailed devices in adults with and without hypertension.","authors":"Tim Weihrauch, Johannes Lemcke, Julia Charlotte Büschges, Jennifer Allen, Patrick Schmich, Ulrich Kintscher, Birga Maier, Hannelore Neuhauser","doi":"10.1097/HJH.0000000000003932","DOIUrl":"10.1097/HJH.0000000000003932","url":null,"abstract":"<p><strong>Objectives: </strong>Home blood pressure monitoring (HBPM) is valuable for the detection and monitoring of hypertension. Despite logistical advantages, HBPM has not yet been used in national blood pressure (BP) surveys. We investigated randomly selected adults' willingness to participate in an HBPM study (attitude survey) and piloted this approach (feasibility study).</p><p><strong>Methods: </strong>The attitude survey, part of the 2020 population representative cross-sectional telephone interview survey, German Health Update (GEDA), assessed willingness to self-measure BP on three days in the morning and evening in 6517 participants. Descriptive analyses and weighted log-binomial regression were used to examine associations between willingness to participate in HBPM and sociodemographic and health factors. The feasibility study piloted self-measurements with mailed devices, video instructions, and before and after online interviews with 258 commercial panel volunteers.</p><p><strong>Results: </strong>In the attitude survey, 38% of randomly selected adults expressed willingness to participate in the HBPM study. Willingness to participate was associated with higher education [risk ratio (RR) 1.63, 95% confidence interval (CI) 1.37-1.94] and medium education (RR 1.30, 95% CI 1.09-1.56) compared to low education, ages 18-39 (RR 1.69, 95% CI 1.45-1.97) and 40-59 (RR 1.37, 95% CI 1.20-1.58) compared to participants from age 60s, and self-reported hypertension (RR 1.19, 95% CI 1.04-1.36). In the feasibility study, 43% ( n  = 110) of those receiving a device completed the study.</p><p><strong>Conclusion: </strong>Our findings suggest that national BP studies cannot rely solely on HBPM because selective participation would yield biased results. However, HBPM may be used in other epidemiological studies, such as longitudinal studies.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"504-512"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the mechanisms of PM2.5's impact on blood pressure: establishing a three-tier response strategy.","authors":"Qiang Sun, Zhiqiang Zhang","doi":"10.1097/HJH.0000000000003920","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003920","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 3","pages":"553"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of broader cognitive screening tools in assessing cognitive decline: a letter to the editor.","authors":"Uzay Cagatay, Lothar Vidal, Warren Chan, Mahindra Bandari","doi":"10.1097/HJH.0000000000003926","DOIUrl":"https://doi.org/10.1097/HJH.0000000000003926","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 3","pages":"554-555"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients.","authors":"Yu-Ling Yu, De-Wei An, Babangida S Chori, Błażej P Kaleta, Gontse Mokwatsi, Dries S Martens, Olugbenga O Abiodun, Tina Anya, Agnieszka Łebek-Szatańska, Jong-Shiuan Yeh, Catharina M C Mels, Agnieszka Latosinska, Ruan Kruger, Godsent Isiguzo, Krzystof Narkiewicz, Muhammad N Shehu, Martin Salazar, Walter Espeche, Blerim Mujaj, Jana Brgulian-Hitij, Agnieszka Olszanecka, Wiktoria Wojciechowska, Peter Reyskens, Marek Rajzer, Andrzej Januszewicz, Katarzyna Stolarz-Skrzypek, Kei Asayama, Karel Allegaert, Peter Verhamme, Harald Mischak, Tim S Nawrot, Augustine N Odili, Jan A Staessen","doi":"10.1097/HJH.0000000000003930","DOIUrl":"10.1097/HJH.0000000000003930","url":null,"abstract":"<p><strong>Objectives: </strong>Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce.</p><p><strong>Methods: </strong>Baseline data (2021-2024) were collected in 168 sub-Saharan Blacks and 93 European Whites in an ongoing clinical trial (NCT04299529), using standardized patient selection criteria. Data included clinical and biochemical risk factors, ECG and echocardiographic traits, Framingham CVD risk, CKD grades (KDIGO 2024), self-assessed symptoms (WHO questionnaire), and urinary proteomic profiles predictive of left ventricular dysfunction (LVD) and CKD, HF1, and CKD273, respectively. Racial comparisons rested on unadjusted and multivariable-adjusted analyses.</p><p><strong>Results: </strong>Despite being younger (60.4 vs. 68.3 years), blacks had a worse risk profile, as evidenced by higher diabetes prevalence, higher BMI, faster heart rate, unfavourable serum cholesterol fractions, lower estimated glomerular filtration rate, microalbuminuria, and sedentary lifestyle. This resulted in blacks having higher 10-year CVD risk, higher heart age (index of vascular ageing with chronological age as reference), and a worse CKD grades. In both races, CKD273 increased with CKD grade, but CKD273 and HF1 were not different by race. These observations were robust in subgroup and adjusted analyses.</p><p><strong>Conclusion: </strong>This study did not differentiate host (genetic, molecular, and pathogenic) from environmental drivers of disease. Nonetheless, the findings call for a multipronged and comprehensive implementation of innovative health policies in sub-Saharan countries. Education, research, empowerment of stakeholders, and international learned societies connecting experts from a wide array of disciplines should vigorously sustain this effort.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"481-491"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index and long-term mortality in patients with hypertension: a cohort study.","authors":"Yaling Zheng, Dongling Zhong, Juan Li, Yue Zhang, Huijing Li, Luoji Liu, Chi Ren, Shan Zhong, Xicen Liu, Xia He, Shiqi Jin, Lun Luo","doi":"10.1097/HJH.0000000000003927","DOIUrl":"10.1097/HJH.0000000000003927","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to examine the relationship between systemic inflammation and long-term mortality in patients with hypertension.</p><p><strong>Methods: </strong>The study employed a retrospective cohort design. The study population was derived from the National Health and Nutrition Examination Survey (NHANES), and the mortality data for this population was acquired from the National Death Index (NDI) database. Systemic inflammation was quantified by the Systemic Immune Inflammation Index (SII) and the Systemic Inflammatory Response Index (SIRI), which were then categorized into four groups (Q1-Q4, with Q4 representing the highest level of SII or SIRI). Weighted Cox regression models were constructed to investigate the association between mortality and SII and SIRI, with hazard ratios (HRs) subsequently calculated.</p><p><strong>Results: </strong>A total of 7431 participants were included in the analysis. The highest quantile (Q4) of SII was associated with a higher risk of all-cause mortality (hazard ratio 1.36, 95% CI 1.1-1.69, P  < 0.001). After adjustment for important covariates, the association remained significant (hazard ratio 1.70, 95% CI 1.27-2.30, P  < 0.001). The highest quantile (Q4) of SIRI was also associated with the highest risk of mortality (hazard ratio 2.11, 95% CI 1.64-2.70, P  < 0.001), and this association remained significant after adjustment for important covariates (hazard ratio 1.64, 95% CI 0.61-1.22, P  = 0.001).</p><p><strong>Conclusion: </strong>Both SII and SIRI scores were found to be associated with mortality rates in patients with hypertension. The findings suggest that these scores may serve as complementary biomarkers to the neutrophil-to-lymphocyte ratio (NLR) for assessing mortality risk in patients with hypertension. Further investigation is warranted to elucidate the underlying mechanisms that underpin this association.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"464-473"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibrutinib pharmacokinetics in B-lymphoproliferative disorders discloses exposure-related incidence of hypertension.","authors":"Loïc Ysebaert, Caroline Protin, Lucie Obéric, Guillaume Beziat, Sandra De Barros, Baptiste Bonneau, Ben Allal, Malika Yakoubi, Anne Quillet-Mary, Fabien Despas","doi":"10.1097/HJH.0000000000003937","DOIUrl":"10.1097/HJH.0000000000003937","url":null,"abstract":"<p><strong>Objective: </strong>Ibrutinib has been the first Bruton tyrosine kinase inhibitor (BTKi) authorized for the treatment of B-cell lymphoproliferative disorders (B-LPDs). Numerous publications have confirmed the efficacy of this orally administrated drug in chemo-free regimens for B-LPDs. They also reported several adverse events (AE) associated with ibrutinib treatment. Whether these AEs depended on ibrutinib exposure has however been seldom explored.</p><p><strong>Methods: </strong>In the study reported here, the incidence of AE was recorded in 92 patients with B-LPD (mostly chronic lymphocytic leukemia n  = 79) for whom ibrutinib alone was proposed as fist line therapy. Moreover, a pharmacokinetics (PK) exploration was planned over one day after 1 month treatment. PK assays included drug and metabolite (DHD-ibrutinib) mean/median and maximal plasmatic concentrations as well as areas under the curve (AUE) data.</p><p><strong>Results: </strong>This PK evaluation was analyzed regarding AEs recorded over the first year of therapy, which were similar as in published reports. PK data disclosed a significant impact of ibrutinib exposure on infections but mostly on the occurrence of hypertension. The latter was mostly related to dihydrodiol-ibrutinib (DHD-ibrutinib) exposure.</p><p><strong>Conclusions: </strong>These data suggest that a DHD-ibrutinib assay after one month of treatment could be interesting to consider a lower dosage for patients above maximal concentration thresholds for the drug, its metabolite or the sum of both. Whether this can be applied to newer BTKi remains to be explored but it could be important for patients to whom ibrutinib is proposed.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"521-528"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of single-pill versus free equivalent combinations on persistence and major adverse cardiovascular events in hypertension: a real-world analysis.","authors":"Gábor Simonyi, Michel Burnier, Krzysztof Narkiewicz, György Rokszin, Zsolt Abonyi-Tóth, Gábor Kovács, Praveen Kumar Potukuchi, Mohamed Abdel-Moneim, Csaba Farsang","doi":"10.1097/HJH.0000000000003916","DOIUrl":"10.1097/HJH.0000000000003916","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension guidelines recommend the use of single-pill combinations (SPCs) of antihypertensive drugs to improve treatment persistence and blood pressure control. This study aimed to investigate the long-term effects of ramipril/amlodipine (R/A) SPC versus free equivalent dose combinations (FEC) on cardiovascular outcomes and treatment persistence.</p><p><strong>Methods: </strong>This retrospective, observational study analysed the database of the Hungarian National Health Insurance Fund. The study included patients with hypertension aged at least 18 years who were initiated on R/A SPC or FEC of different dose combinations (R/A 5/5, 5/10, 10/5 and 10/10 mg) between 2012 and 2018, with follow-up for up to 60 months. Imbalances in baseline characteristics were reduced with propensity score-based sub-classification. All analyses were performed with Cox proportional hazard model and propensity score sub-classification to adjust the imbalances in baseline characteristics. Drug persistence and MACEs were the primary and secondary endpoints, respectively.</p><p><strong>Results: </strong>Overall, 104 882 patients with SPC and 68 324 patients with FEC-treated hypertension were included. The R/A 5/5 mg combination represented the largest proportion (62%). The nonpersistence rate was significantly lower with SPC than with FEC from month 1 to month 24 in the R/A 5/5 mg combination ( P  < 0.001) and during the entire observation period in the remaining combinations. The MACE rate was significantly reduced with all R/A SPCs versus FECs. No effects on age and sex on both endpoints were noted.</p><p><strong>Conclusion: </strong>This study further supports the beneficial effects of the use of SPC on 60-month persistence and MACEs in hypertension.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"405-412"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}