Journal of Hypertension最新文献

{"title":"Blood pressure variability: a review.","authors":"Spoorthy Kulkarni, Gianfranco Parati, Sripal Bangalore, Grzegorz Bilo, Bum Joon Kim, Kazuomi Kario, Franz Messerli, George Stergiou, Jiguang Wang, William Whiteley, Ian Wilkinson, Peter S Sever","doi":"10.1097/HJH.0000000000003994","DOIUrl":"10.1097/HJH.0000000000003994","url":null,"abstract":"<p><p>Blood pressure variability (BPV) predicts cardiovascular events independent of mean blood pressure. BPV is defined as short-term (24-h), medium or long- term (weeks, months or years). Standard deviation, coefficient of variation and variation independent of the mean have been used to quantify BPV. High BPV is associated with increasing age, diabetes, smoking and vascular disease and is a consequence of premature ageing of the vasculature. Long-term BPV has been incorporated into cardiovascular risk models (QRISK) and elevated BPV confers an increased risk of cardiovascular outcomes even in subjects with controlled blood pressure. Long-acting dihydropyridine calcium channel blockers and thiazide diuretics are the only drugs that reduce BPV and for the former explains their beneficial effects on cardiovascular outcomes. We believe that BPV should be incorporated into blood pressure management guidelines and based on current evidence, long-acting dihydropyridines should be preferred drugs in subjects with elevated BPV.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"929-938"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium channel blockers and mental health: a comprehensive meta-analysis of psychiatric adverse events in double-blind randomized controlled trials.","authors":"Marc-Alexander Fürtig, Yana Kovalenko, Reinhold Kreutz, Thomas G Riemer","doi":"10.1097/HJH.0000000000004011","DOIUrl":"10.1097/HJH.0000000000004011","url":null,"abstract":"<p><strong>Objective: </strong>L-type calcium channel blockers (CCBs) are pivotal in managing cardiovascular disorders, such as hypertension and angina pectoris. Their action on L-type calcium channels, which are not only integral to cardiovascular function but also present in the brain, prompts questions about potential effects on mental health. While previous cohort studies explored this association with mixed results, our study aims to build upon these findings by systematically investigating psychiatric adverse events (PAEs) reported in double-blind randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>A systematic search identified double-blind RCTs reporting frequencies of PAEs during CCB therapy across different indications. Separate meta-analyses were conducted for dihydropyridine (DHP) and nondihydropyridine (non-DHP) CCBs against placebo and active controls. This study was registered on INPLASY (INPLASY202480075).</p><p><strong>Results: </strong>In 187 studies, encompassing 28,201 patients exposed to CCBs, several PAEs were reported, with the most common being depression, insomnia, somnolence, and agitation. Meta-analyses revealed no significant difference in PAE occurrence for CCBs vs. placebo, β-blockers, renin-angiotensin system blockers, and thiazide/thiazide-like diuretics (all P  > 0.05). Restricting the analyses to cardiovascular studies, DHP CCBs were linked to lower risks of depression and insomnia compared to placebo [odds ratio (OR) 0.84, confidence interval (CI) 0.70-1.00 and OR 0.38, CI 0.15-0.99, both P  = 0.05); however, these results may be artifacts and should be interpreted with caution.</p><p><strong>Conclusion: </strong>Concerns about negative mental health effects of CCBs appear to be unwarranted and should not deter clinicians from prescribing them when indicated. A detected signal towards positive mental health benefits in cardiovascular patients warrants further investigation.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1049-1056"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time series proteome profile analysis reveals a protective role of citrate synthase in angiotensin II-induced atrial fibrillation: Erratum.","authors":"","doi":"10.1097/HJH.0000000000004012","DOIUrl":"10.1097/HJH.0000000000004012","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 6","pages":"1089"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Day-to-day blood pressure variability in older persons - optimizing measurement.","authors":"Tanya Palsma, Jurgen A H R Claassen, Edo Richard, Rianne A A De Heus","doi":"10.1097/HJH.0000000000003975","DOIUrl":"10.1097/HJH.0000000000003975","url":null,"abstract":"<p><strong>Background: </strong>Higher blood pressure variability (BPV) is associated with adverse clinical outcomes but lack of standardized methodology hampers clinical translation. Day-to-day BPV seems most promising for an older population, especially those with cognitive impairment. This study aimed to determine the optimal number of measurements for obtaining day-to-day BPV in this population.</p><p><strong>Methods: </strong>We included 127 patients attending the geriatric outpatient memory clinic, who measured blood pressure for seven days, morning and evening. Blood pressure measurements of day one were discarded and the coefficient of variation was calculated to assess BPV. Concordance between 7-day BPV (CV 7days ) and a reduced number of measurement days (CV 6days - CV 3days ) was analysed with Bland-Altman plots, intraclass correlation coefficient (ICC), and an a priori determined threshold of a 95% confidence interval (CI) with a lower bound of 0.75.</p><p><strong>Results: </strong>The mean age was 74.6 ± 8.6 years, 49% were female, and had dementia or mild cognitive impairment in 37% and 33% respectively. Reducing the number of measurement days resulted in wider limits of agreement. Concordance decreased when reducing measurement days and reached our predefined threshold with four measurement days (ICC = 0.91, 95% CI = 0.87 - 0.93). BPV derived from five measurement days showed a similar relationship with diagnosis as our reference BPV value obtained with seven days.</p><p><strong>Conclusion: </strong>Our results suggest that systolic home blood pressure should be measured in the morning and evening for at least five consecutive days in duplicate to obtain reliable day-to-day BPV values in older adults with cognitive complaints.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"970-975"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing causal relationships between gut microbiotas, metabolites, and pulmonary arterial hypertension through univariate Mendelian randomization study and bioinformatics analysis.","authors":"Dongrui Xu, Hong Liu, Jiankang Yang","doi":"10.1097/HJH.0000000000004003","DOIUrl":"10.1097/HJH.0000000000004003","url":null,"abstract":"<p><strong>Background: </strong>Recent research has linked gut microbiotas and metabolites to the development and progression of pulmonary arterial hypertension (PAH) through the gut-lung axis. However, current studies on the causal relationship between gut microbiotas, gut microbiota derived metabolites, and PAH lack conclusive evidence. This study employed Mendelian randomization and bioinformatics analysis to reveal the possible causal links among them.</p><p><strong>Methods: </strong>Summary statistics of gut microbiotas, metabolites, and PAH were from GWAS. Univariate Mendelian randomization (inverse variance weighted and weighted median), reverse Mendelian randomization, and verification through other PAH GWAS cohorts were used to analyze the possible causal relationships between these gut microbiotas or gut microbiota derived metabolites and PAH. In addition, Cochran's Q statistic, MR-Egger regression intercept, MR-PRESSO global test, and the leave-one-out method were used for the sensitivity analysis. Based on this, we carried out an initial bioinformatics analysis to investigate its potential biological mechanisms.</p><p><strong>Results: </strong>Preliminary screening of the present research revealed four gut microbiotas ( Genus Eubacteriumfissicatenagroup , Genus RuminococcaceaeUCG002, Genus Tyzzerella3, and Genus Sutterella) and one metabolite (taurolithocholate 3-sulfate) correlated with PAH. However, after validation in other PAH GWAS cohorts, only genetically increased Genus Tyzzerella3 (odds ratio: 0.54, 95% confidence interval: 0.37-0.80, P  = 0.0018) correlated with a reduced risk for PAH, a relationship may be related to the keratan sulfate and glycosphingolipid synthesis. No significant heterogeneity, pleiotropy, or reversal causation effect was observed ( P  > 0.05).</p><p><strong>Conclusion: </strong>Our Mendelian randomization analysis establishes a significant correlation between Genus Tyzzerella3 and PAH, positioning it as a prominent protective factor for PAH.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1003-1011"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An I-Change approach to understanding exercise determinants among Black individuals with hypertension.","authors":"Donya Nemati, Adrián Noriega de la Colina, Kathy D Wright, Joshua J Joseph, Navin Kaushal","doi":"10.1097/HJH.0000000000003974","DOIUrl":"10.1097/HJH.0000000000003974","url":null,"abstract":"<p><strong>Objective: </strong>Black populations are disproportionately affected by hypertension and are less likely to engage in blood pressure-lowering activities, such as exercise, compared to non-Hispanic White populations. There is a lack of theory-informed approaches to understand how individual and environmental racial disparities impact exercise participation among Black individuals with hypertension. The I-Change Model, an integrated behavior change framework, combines concepts from social and health psychology to explain the interaction between awareness, motivation, and action in adopting and maintaining health behaviors. This study aims to apply an augmented version of the I-Change Model to enhance our understanding of racial disparities in exercise participation.</p><p><strong>Methods: </strong>Individuals with self-reported doctor-diagnosed hypertension ( N  = 370), comprising Black ( n  = 142) and White ( n  = 228) adults who were recruited via an online recruitment platform, completed a survey with validated theoretical constructs at baseline and at 4 weeks. Structural equation modeling with race set as a group variable was used to among both races, intention predicted exercise behavior model path effects.</p><p><strong>Results: </strong>Among both races, intention positively influenced exercise behavior, whereas psychological barriers reduced the likelihood of engaging in the behavior. However, notable racial disparities among Black participants included environmental barriers (e.g., safety, accessibility to a gym) that hindered exercise behavior and affective attitudes that did not facilitate intention.</p><p><strong>Conclusions: </strong>An exercise promotion program that fosters I-Change determinants and creates an accessible, supportive environment would enhance equitable exercise opportunities for Black individuals with hypertension. Additional recommendations for designing such a program are provided.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"961-969"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cardiovascular repercussions in women with previous pregnancies complicated by severe hypertensive disease.","authors":"Renata Gomes Sanches Verardino, Thiago Andrade de Macedo, Sara Rodrigues, Valéria Costa Hong, Fernanda Spadotto Baptista, Maria Rita de Figueiredo Lemos Bortolotto, Rossana Pulcineli Vieira Francisco, Luiz Aparecido Bortolotto","doi":"10.1097/HJH.0000000000003999","DOIUrl":"10.1097/HJH.0000000000003999","url":null,"abstract":"<p><strong>Objective: </strong>To assess the long-term functional and structural repercussions of the heart and vessels in women with a history of severe preeclampsia (PE).</p><p><strong>Methods: </strong>A cross-sectional study conducted at a tertiary hospital involving women 2-5 years postpregnancy, divided into three groups: isolated preeclampsia (de novo PE = 30), superimposed PE and/or chronic hypertension (PEs/HC= 60), and normal gestation (NG = 30). We evaluated age, body mass index (BMI), office systolic (SBP) and diastolic blood pressure (DBP), 24-h ambulatory blood pressure monitoring (ABPM), noninvasive central blood pressure (CBP) by tonometry (sphygmocor), pulse wave velocity (PWV - complior), and echocardiography (ViviDI-GE).</p><p><strong>Results: </strong>Age (38 ± 5 years) and BMI (32.6 ± 6 k/m 2 ) were higher in PEs/HC. Office SBP (mmHg) was higher in de novo PE (124.8 ± 11) and PEs/HC (133.6 ± 19) than NG (114.6 ± 9), and DBP (mmHg) was higher in PEs/HC (87.8 ± 12) than NG (73.3 ± 8) and de novo PE (80.4 ± 12). ABPM showed higher SBP in all periods for PEs/HC than NG and de novo PE. Central SBP was higher in PEs/HC and De novo PE compared to NG and De novo PE. Carotid-femoral PWV (m/s) was higher in PEs/HC (8.1 ± 2) than NG (6.8 ± 1) and de novo PE (7.0 ± 1). Echocardiography revealed increased septal thickness and left atrial diameter in PEs/HC, with a higher left ventricular (LV) mass index in de novo PE and PEs/HC than NG.</p><p><strong>Conclusion: </strong>Women with previous de novo PE have higher office and central blood pressure values and greater ventricular mass compared to those with previous normal pregnancies. The most significant cardiovascular repercussions were observed in women with previous superimposed PE or chronic hypertension during pregnancy.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"951-960"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study.","authors":"Jun Qian, Zhongzheng Zhou, Yiwen Zheng, Shunkang Rong, Yuanqing Yao, Bo Xiong, Weiran Dai, Yun Du, Han Liu, Wei Sha, Dichuan Liu, Changming Deng, Jing Huang","doi":"10.1097/HJH.0000000000004005","DOIUrl":"10.1097/HJH.0000000000004005","url":null,"abstract":"<p><p>This study aimed to evaluate the feasibility and efficacy of a catheter-based ultrasound renal denervation (RDN) system for nerve mapping guided RDN and treatment efficacy verification. A total of five patients were sequentially enrolled. Low-power pulsed ultrasound stimulation was applied at the distal, middle and proximal segments of the renal arteries, in both head-foot and abdomen-back directions. Ultrasound RDN was selectively performed at sites where SBP increased by at least 5 mmHg following stimulation. Supplementary RDN was conducted at any sites exhibiting an SBP increase of at least 5 mmHg after re-stimulation. A total of 60 directional stimulations were applied across 10 renal arteries, with 70% of these directions received ultrasound RDN. The daytime ambulatory SBP decreased from 151 to 130 mmHg after two months. These findings indicate that catheter-based ultrasound renal mapping guided RDN might feasible and could offer a more targeted approach to the RDN procedure.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1083-1085"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr Hassan's letter regarding our article Pharmacotherapy of arterial hypertension in patients with psoriasis.","authors":"Jozef Dodulík","doi":"10.1097/HJH.0000000000004017","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004017","url":null,"abstract":"","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":"43 6","pages":"1087-1088"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a single session of low- and high-intensity velocity-based resistance exercise on blood pressure in patients with hypertension.","authors":"Luis A Benavides-Roca, Germán Parra, Antonio R Zamunér","doi":"10.1097/HJH.0000000000004015","DOIUrl":"10.1097/HJH.0000000000004015","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of high and low-intensity velocity-based resistance exercise on blood pressure in individuals with hypertension.</p><p><strong>Methodology: </strong>A crossover clinical trial was performed. Thirty-three participants with diagnosis of hypertension took part in the study. Participants underwent two sessions of resistance training: low-intensity, characterized by 12 repetitions and 6 sets at 40% of one-repetition maximum velocity; high-intensity, characterized by 6 repetitions and 6 sets at 80% of one-repetition maximum velocity. A 1-week washout was considered between the sessions. Participants were randomly assigned to exercise intensity at the first session. Blood pressure was measured by an automated device before and immediately after both sessions. 24-h ambulatory blood pressure monitoring (ABPM) was performed after the sessions. Significance level was set at 5%.</p><p><strong>Outcomes: </strong>The results showed that low-intensity resistance exercises significantly decreased systolic (≈5 mmHg), diastolic (≈4 mmHg) and mean arterial blood pressure (≈4 mmHg), which was not observed after the high-intensity exercise. No significant differences were found between exercise sessions for the post 24-h ABPM.</p><p><strong>Conclusion: </strong>Low-intensity resistance exercise was more effective in decreasing blood pressure in patients with hypertension than a high-intensity protocol.</p>","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1075-1082"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}