Journal of Hypertension最新文献_第9页

Adrenalectomy versus esaxerenone: comparison of vascular benefits in patients with aldosterone-producing adenoma. 肾上腺切除术与艾赛酮：醛固酮产生腺瘤患者血管获益的比较。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-31 DOI: 10.1097/HJH.0000000000004425

Shinji Kishimoto, Tatsuya Maruhashi, Masato Kajikawa, Aya Mizobuchi, Takahiro Harada, Takayuki Yamaji, Yukiko Nakano, Chikara Goto, Farina Mohamad Yusoff, Yukihito Higashi

{"title":"Adrenalectomy versus esaxerenone: comparison of vascular benefits in patients with aldosterone-producing adenoma.","authors":"Shinji Kishimoto, Tatsuya Maruhashi, Masato Kajikawa, Aya Mizobuchi, Takahiro Harada, Takayuki Yamaji, Yukiko Nakano, Chikara Goto, Farina Mohamad Yusoff, Yukihito Higashi","doi":"10.1097/HJH.0000000000004425","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004425","url":null,"abstract":"Objective: The efficacy of adrenalectomy compared to the efficacy of treatment with esaxerenone in improving vascular function and arterial stiffness in patients with aldosterone-producing adenoma (APA) remains uncertain. The aim of this study was to determine the effects of esaxerenone on blood pressure, serum potassium, vascular function and arterial stiffness in patients with APA and to compare the effects of adrenalectomy and treatment with esaxerenone on vascular function and arterial stiffness as surrogate markers of cardiovascular events.Methods: Flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation (NID), and brachial-ankle pulse wave velocity (baPWV) were measured to assess vascular function and arterial stiffness before and after 3-month treatment with esaxerenone and at 3 months after adrenalectomy in 20 patients with APA.Results: FMD, NID, and baPWV after treatment with esaxerenone were significantly better than those before treatment with esaxerenone. FMD, NID, and baPWV after adrenalectomy were significantly better than those before treatment with esaxerenone. NID after adrenalectomy was significantly higher than that after treatment with esaxerenone (14.9 ± 4.8% vs. 13.0 ± 4.6%, P = 0.03). The changes in FMD, NID, and baPWV after adrenalectomy were significantly correlated with the changes in plasma aldosterone concentration.Conclusions: Compared with esaxerenone treatment, adrenalectomy provided more favorable improvements in vascular function and arterial stiffness in patients with APA. Nevertheless, esaxerenone also improved blood pressure, serum potassium levels, vascular function, and arterial stiffness, suggesting that it may be a beneficial treatment option for patients with APA who are inoperable or refuse surgery.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in associations of periodontitis with blood pressure and arterial stiffening: the Hordaland Health Study. 牙周炎与血压和动脉硬化相关的性别差异：Hordaland健康研究。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004418

Ester Kringeland, Ellen Berggreen, Dagmar F Bunæs, Gerhard Sulo, Knut Helge M Jensen, Hager R Z Elabdeen, Helga Midtbø, Siri Kvalheim, Anne Isine Bolstad, Eva Gerdts

{"title":"Sex differences in associations of periodontitis with blood pressure and arterial stiffening: the Hordaland Health Study.","authors":"Ester Kringeland, Ellen Berggreen, Dagmar F Bunæs, Gerhard Sulo, Knut Helge M Jensen, Hager R Z Elabdeen, Helga Midtbø, Siri Kvalheim, Anne Isine Bolstad, Eva Gerdts","doi":"10.1097/HJH.0000000000004418","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004418","url":null,"abstract":"Objectives: Periodontitis may promote chronic systemic inflammation leading to elevation of blood pressure (BP) and arterial stiffening. We explored sex-specific associations of periodontitis severity and inflammation with BP and arterial stiffness.Methods: BP and arterial stiffness by carotid-femoral pulse wave velocity (cf-PWV) were measured in 673 women and 565 men, mean age 68 years. Periodontitis was staged using the European Federation of Periodontology/American Academy of Periodontology 2018 classification. Periodontal inflammation was assessed by full-mouth registration of bleeding on probing (BoP) and number of sites with combined probing pocket-depth (PPD) ≥ 4 mm and BoP. The associations of periodontitis severity and periodontal inflammation with BP and arterial stiffness were tested in sex-specific linear/logistic regression analyses, adjusted for diabetes, smoking, BMI, education, and antihypertensive treatment.Results: Men had higher BP and cf-PWV than women (both P < 0.01). Stage II (moderate) and III/IV (advanced) periodontitis were found in 24 and 76% of women and 18 and 82% of men (P = 0.03). Mean BoP was 55 in both genders (P = 0.91). In adjusted analysis, stage III/IV (advanced) periodontitis was associated with higher SBP and DBP in women only (β = 0.08 and β = 0.09, both P < 0.05). BoP was associated with higher DBP only in women (β = 0.12) (P for sex interaction < 0.05) and with higher cf-PWV in men (β = 0.09) (both P < 0.05). PPD ≥ 4 mm with BoP was associated with increased arterial stiffness in women (P = 0.03).Conclusion: Advanced periodontitis and periodontal inflammation were both associated with higher BP only in women, while periodontal inflammation was associated with increased arterial stiffness in both genders.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated urinary angiotensinogen excretion links incidence of chronic kidney disease among community-dwelling population: The Aging Kidney Study. 尿血管紧张素原排泄升高与社区居民慢性肾病发病率相关：老龄化肾脏研究

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004421

Shun Yoshikoshi, Keisei Kosaki, Shoya Mori, Seiji Maeda, Makoto Kuro-O, Kunihiro Yamagata

{"title":"Elevated urinary angiotensinogen excretion links incidence of chronic kidney disease among community-dwelling population: The Aging Kidney Study.","authors":"Shun Yoshikoshi, Keisei Kosaki, Shoya Mori, Seiji Maeda, Makoto Kuro-O, Kunihiro Yamagata","doi":"10.1097/HJH.0000000000004421","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004421","url":null,"abstract":"Objectives: Activation of the intrarenal renin-angiotensin system (RAS) has been implicated in chronic kidney disease (CKD) pathophysiology. Although urinary angiotensinogen (AGT) is a noninvasive surrogate marker of intrarenal RAS activity, whether urinary AGT is associated with incident CKD remains unclear. We investigated the association between urinary AGT and incident CKD in community-dwelling adults without CKD.Methods: We conducted a prospective cohort study of community-dwelling adults without CKD. Urinary AGT, urinary N-acetyl-β-d-glucosaminidase (NAG), urinary β2-microglobulin (β2-MG), urinary albumin-to-creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR) were assessed at baseline. Incident CKD was defined according to established criteria based on eGFR and urinary ACR during follow-up. Associations between urinary AGT levels and incident CKD were examined using multivariable-adjusted Cox proportional hazards models.Results: Among 197 participants without CKD at baseline, 22% developed incident CKD during a median follow-up of 4.9 years. Weak to moderate correlations were observed between urinary AGT levels and kidney-related markers at baseline, including an inverse correlation with eGFR (ρ = -0.21) and positive correlations with urinary ACR (ρ = 0.44), urinary NAG (ρ = 0.35), and urinary β2-MG (ρ = 0.56). Higher baseline urinary AGT levels were significantly associated with an increased risk of incident CKD [adjusted hazard ratio per 1-SD increase, 1.48; 95% confidence interval (CI), 1.02-2.16] after multivariable adjustment.Conclusion: Higher urinary AGT levels were associated with incident CKD in individuals with preserved kidney function, suggesting that urinary AGT may serve as a marker of early CKD risk.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of the magnitude of the white-coat effect in hypertension. 高血压患者白大褂效应大小的预后意义。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004416

Alejandro de la Sierra, Natalie Staplin, Luis M Ruilope

{"title":"Prognostic significance of the magnitude of the white-coat effect in hypertension.","authors":"Alejandro de la Sierra, Natalie Staplin, Luis M Ruilope","doi":"10.1097/HJH.0000000000004416","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004416","url":null,"abstract":"Background: White-coat effect (WCE) is defined as the difference between office and daytime ambulatory blood pressure (BP). We aimed to evaluate the association between the magnitude of the WCE and all-cause and cardiovascular mortality in patients with hypertension.Methods: Forty-five thousand three hundred twenty-nine patients with office SBP at least 130 and a WCE more than 0 mmHg and 37 447 with office DBP at least 80 mmHg and a WCE more than 0 mmHg were studied. Follow-up was 9.7 years. For either systolic or diastolic WCE, hazard ratios were calculated for 1 standard deviation increase in Cox-regression models adjusted for clinical confounders and 24-h SBP. In addition, the highest and mid tertiles of the WCE distribution were compared to the lowest tertile (reference group).Results: In adjusted models, WCE was associated with all-cause mortality [hazard ratio for 1 SD increase: 1.13; 95% confidence interval (95% CI): 1.07-1.19, for systolic and 1.25; 95% CI: 1.17-1.34 for diastolic]. In addition, compared to the lowest tertile of the WCE distribution, the highest tertile of both systolic and diastolic WCE was associated with increased rates of all-cause mortality (1.15; 95% CI: 1.07-1.23 and 1.24; 95% CI: 1.13-1.35), respectively, for systolic and diastolic WCE, after adjustments. Similar results were observed for cardiovascular mortality.Conclusion: An exaggerated WCE effect is associated with increased rates of all-cause and cardiovascular mortality. This association, along with the presence of other cardiovascular risk factors, suggests that an exaggerated WCE is not merely the result of an alert reaction, but also associated with a more advanced disease.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of visit-to-visit blood pressure variability with kidney disease progression and cardiovascular outcomes in the chronic renal insufficiency cohort (CRIC). 慢性肾功能不全队列（CRIC）中，每次就诊血压变异性与肾脏疾病进展和心血管结局的关系

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004410

Rushelle L Byfield, Rachel Zhang, Alavi Hossain, Debbie L Cohen, Raymond R Townsend, Ian M Kronish, Daichi Shimbo, Jordana B Cohen

{"title":"Association of visit-to-visit blood pressure variability with kidney disease progression and cardiovascular outcomes in the chronic renal insufficiency cohort (CRIC).","authors":"Rushelle L Byfield, Rachel Zhang, Alavi Hossain, Debbie L Cohen, Raymond R Townsend, Ian M Kronish, Daichi Shimbo, Jordana B Cohen","doi":"10.1097/HJH.0000000000004410","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004410","url":null,"abstract":"Background: Visit-to-visit variability (VVV) of blood pressure (BP) has been linked to adverse cardiovascular and kidney outcomes in various populations, but results in those with chronic kidney disease (CKD) have been inconsistent.Methods: We evaluated VVV in Chronic Renal Insufficiency Cohort (CRIC) participants, using the coefficient of variation (CoV = standard deviation of SBP/mean SBP) calculated from BP measurements obtained at baseline visit through year 5 of the study. Cox proportional hazards models were used to assess the association of CoV with a composite cardiovascular outcome (myocardial infarction, stroke, peripheral artery disease, heart failure) and a composite kidney outcome (50% reduction in estimated glomerular filtration rate or end-stage kidney disease).Results: Among 3891 participants (44% women, mean age 63 ± 10 years, mean CoV 10.3 ± 5.2%), 757 cardiovascular and 920 kidney events occurred during a median follow-up of 5.4 and 4.5 years, respectively. In unadjusted analyses, the upper tertile of CoV was associated with increased risk of both cardiovascular [hazard ratio 2.04, 95% confidence interval (CI) 1.70-2.43] and kidney outcomes (hazard ratio 1.62, 95% CI 1.38-1.89) compared to the lowest tertile. However, after adjustment for clinical and sociodemographic factors, higher CoV was significantly associated with cardiovascular outcomes (adjusted hazard ratio 1.25, 95% CI 1.04-1.52) but not kidney outcomes (adjusted hazard ratio 0.95, 95% CI 0.80-1.15).Conclusion: In this large CKD cohort, higher visit-to-visit BP variability was independently linked to adverse cardiovascular, but not kidney, outcomes.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term treatment with soluble guanylyl cyclase stimulator BAY41-8543 abolishes malignant hypertension-related mortality and attenuates organ damage: studies in Ren-2 transgenic rats treated with L-NAME. 长期服用可溶性胍基环化酶刺激剂BAY41-8543可消除恶性高血压相关死亡率并减轻器官损害：用L-NAME治疗Ren-2转基因大鼠的研究

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-13 DOI: 10.1097/HJH.0000000000004422

Martina Hüttl, Matúš Miklovič, Petra Škaroupková, Zdenka Vaňourková, Soňa Kikerlová, Janusz Sadowski, Michal Šnorek, Peter Sandner, Luděk Červenka

{"title":"Long-term treatment with soluble guanylyl cyclase stimulator BAY41-8543 abolishes malignant hypertension-related mortality and attenuates organ damage: studies in Ren-2 transgenic rats treated with L-NAME.","authors":"Martina Hüttl, Matúš Miklovič, Petra Škaroupková, Zdenka Vaňourková, Soňa Kikerlová, Janusz Sadowski, Michal Šnorek, Peter Sandner, Luděk Červenka","doi":"10.1097/HJH.0000000000004422","DOIUrl":"https://doi.org/10.1097/HJH.0000000000004422","url":null,"abstract":"Objective: Malignant hypertension (MH) remains a life-threatening condition and new pharmacological strategies and drugs with potential new mode of actions are currently investigated. The aim of the present study was to evaluate the effects of nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) stimulator on the long-term MH-related mortality and morbidity.Methods: As a model of MH, Ren-2 transgenic rats (TGR) treated with nonspecific NO synthase inhibitor, [Nω-nitro-l-arginine methyl ester - (L-NAME)], was used. Systolic blood pressure (SBP) was measured by tail-cuff method. The treatment with sGC stimulator, BAY41-8543, was started 3 days before administration of L-NAME. The follow-up period was 120days after L-NAME administration.Results: Untreated TGR + L-NAME rats developed MH (SBP on day +10 was 207 ± 4 mmHg) associated with development of marked albuminuria and high mortality (median survival rate 8 days). The treatment with sGC stimulator BAY41-8543 completely abolished MH-related mortality in TGR receiving L-NAME (all animals survived until end of the study) and prevented rises in SBP and development of albuminuria.Conclusion: The treatment with sGC stimulator BAY41-8543 provided long-term protection against MH-related mortality and morbidity. On the whole, these results suggest that pharmacological targeting NO/sGC pathway should be considered in attempts to develop new pharmacological strategies for treatment of MH.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The MDS-arterial stiffness link: interpreting what remains unmeasured. mds与动脉僵硬度的联系：解释仍未测量的东西。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004334

Almas Gul, Ramsha Gul

引用次数: 0

Update from the National Hypertension Taskforce of Australia: prevalence, treatment and control rates of hypertension between 2022 and 2024 - implications and future directions. 来自澳大利亚国家高血压工作组的最新信息：2022年至2024年间高血压的患病率、治疗和控制率——含义和未来方向。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-05-27 DOI: 10.1097/HJH.0000000000004358

Amelie H Ohlrogge, Xiaoyue Xu, Andrew Goodman, Garry Jennings, Lisa Murphy, Mark R Nelson, James E Sharman, Rob Tassie, Markus P Schlaich, Aletta E Schutte

{"title":"Update from the National Hypertension Taskforce of Australia: prevalence, treatment and control rates of hypertension between 2022 and 2024 - implications and future directions.","authors":"Amelie H Ohlrogge, Xiaoyue Xu, Andrew Goodman, Garry Jennings, Lisa Murphy, Mark R Nelson, James E Sharman, Rob Tassie, Markus P Schlaich, Aletta E Schutte","doi":"10.1097/HJH.0000000000004358","DOIUrl":"10.1097/HJH.0000000000004358","url":null,"abstract":"High blood pressure is the dominant risk factor for cardiovascular diseases and death in Australia. The blood pressure control rate in Australia was reported at 32% based on 2017-2018 data, which is substantially lower than other high-income countries. New results from the National Health Survey show an improvement of the crude control rate to 39.6% in the years 2022-2023, though changes in methodology need to be considered in the interpretation. Hypertension prevalence has increased from 33.7 to 39.4%. The prevalence and control rates vary strongly across diverse population groups. The age-standardized prevalence among First Nations peoples is higher than in the general population (37.8 versus 35%), and age-standardized blood pressure control rates are lower (22.2 versus 31.1%). Younger individuals and those in socioeconomically disadvantaged areas have substantially lower control rates, highlighting the need for greater equity to achieve the National Hypertension Taskforce's goal of 70% blood pressure control by 2030.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"1457-1461"},"PeriodicalIF":5.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension in autoimmune rheumatic diseases: progress made, gaps remain. 自身免疫性风湿病高血压：取得进展，仍有差距。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004344

Gisele Facholi Bomfim, Michael J Ryan, Leonardo Bonilha, Cameron G McCarthy, Camilla F Wenceslau

引用次数: 0

Reply to comment: Limited public understanding of the risk factors and complications of hypertension. 回复评论：公众对高血压危险因素和并发症的了解有限。

IF 5.6 2区医学

Journal of Hypertension Pub Date : 2026-08-01 Epub Date: 2026-06-25 DOI: 10.1097/HJH.0000000000004346

Mingjuan Zeng, Sonali R Gnanenthiran, David K E Chan, Ruth Griffiths, Aletta E Schutte

引用次数: 0