Journal of Human Reproductive Sciences最新文献

{"title":"Combined Parental Thrombophilia Gene Mutation Defects in Couples with Repeated Pregnancy Loss.","authors":"Mehdi Kashifard, Zahra Basirat, Fatemeh Ramezani, Faeze Ghofrani, Masoumeh Golsorkhtabaramiri","doi":"10.4103/jhrs.jhrs_137_23","DOIUrl":"10.4103/jhrs.jhrs_137_23","url":null,"abstract":"<p><strong>Background: </strong>Several genetic mutations in female thrombotic defects have recently been shown to affect recurrent pregnancy loss (RPL); however, it is unclear which common parental mutations are involved in thrombosis-associated repeated pregnancy loss RPL.</p><p><strong>Aims: </strong>In this study, the prevalence of some combined parental thrombophilia gene mutation defects was studied in couples with RPL.</p><p><strong>Settings and design: </strong>The observational study was done in babol infertility research center (Iran) in 2022.</p><p><strong>Materials and methods: </strong>Sixty-two infertile women with a history of RPL and their male partners (124 individuals) participated in this study. The frequencies of common defects associated with methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, factor V Leiden, protein C, protein S and homocysteine were analysed in these couples.</p><p><strong>Statistical analysis used: </strong>The data were statistically analysed using the Mann-Whitney test.</p><p><strong>Results: </strong>Sixty-two couples (124 individuals) were analysed. 56.2% of couples with a history of RPL had MTHFR C677T and 23.1% had MTHFR A1298C. Forty percent of couples showed homocysteine deficiency and 12.5% protein C deficiency. Other genes tested were only observed in the mother or father but not both.</p><p><strong>Conclusions: </strong>Results obtained with RPL couples demonstrate the importance of further investigating combined parental thrombophilia gene mutation defects (not only maternal).</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"352-357"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of psychological entitlement and abusive supervision on organizational deviance in cabin attendants","authors":"Seçil Ulufer Kansoy, Can Burak Nalbantoğlu","doi":"10.14687/jhs.v20i4.6403","DOIUrl":"https://doi.org/10.14687/jhs.v20i4.6403","url":null,"abstract":"The behavior of employees and managers within the organization is often an influential factor in the functioning of the organization. Therefore, some issues in organizations constitute a particular area of investigation. In this context, the aim of study is to measure the impact of psychological entitlement and abusive supervision on organizational deviance The data of the study consisted of 271 full-time employees in organizations operating within the scope of airline transportation in Istanbul. Relational survey method was used in the study. In the study, the psychological entitlement scale adapted into Turkish by Kürü (2022), the organizational deviance scale adapted into Turkish by Gültaç (2019) and the abusive supervision scale adapted into Turkish by Ülbeği, Özgen and Özgen (2014) were used. Confirmatory factor analysis (CFA) was conducted to test the validity of the scales used in the research. Kruskal Wallis test, Mann Whitney U test, correlation and regression analyses were conducted to test the problems in the research. Among the scales used in the study, the Cronbach Alpha value of the psychological entitlement scale is 0.86, the Cronbach Alpha value of the abusive supervision scale is 0.97 and the Cronbach Alpha value of the organizational deviance scale is 0.96. According to the results of confirmatory factor analysis with structural equation modeling, the scales were found to be appropriate for the study. When the findings are analyzed, psychological entitlement, organizational deviance and abusive supervision dimensions did not differ significantly with gender, age, marital status and length of service in the organization. Those with undergraduate education have the highest mean for psychological entitlement, those with graduate education have the highest mean for organizational deviance, and those with graduate education have the highest mean for abusive supervision. Abusive supervision has a positive very low-level correlation with psychological entitlement and a positive low-level correlation and significant relationship with organizational deviance. In conclusion, psychological entitlement and abusive supervision did not have any predictive effect on organizational deviance. (Extended English summary is at the end of this document) Özet Örgütteki çalışan ve yöneticilerin davranışları, örgütün işleyişini etkileyen önemli faktörlerdendir. Bu nedenle örgütlerde bazı konular özellikle bir inceleme alanı oluşturmaktadır. Bu kapsamda çalışmanın amacı psikolojik ayrıcalık ve istismarcı yönetimin örgütsel sapma üzerindeki etkisini ölçmektir. Araştırmanın verisi, İstanbul’da havayolu taşımacılığı kapsamında faaliyet gösteren örgütlerde tam zamanlı çalışan statüsündeki 271 personel oluşturmaktadır. Araştırmada ilişkisel tarama yöntemi kullanılmıştır. Çalışmada Kürü (2022) tarafından Türkçe’ye uyarlanan psikolojik ayrıcalık ölçeği, Gültaç (2019) tarafından Türkçe’ye uyarlanan örgütsel sapma ölçeği ve Ülbeği, Özgen ve Özgen (2014) tarafınd","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135407404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Assisted Reproductive Outcomes in Women with Different Polycystic Ovary Syndrome Phenotypes Undergoing Frozen Embryo Transfer.","authors":"Anubhuti Patel, Anviti Saraf, Vyshnavi A Rao, Kamini A Rao","doi":"10.4103/jhrs.jhrs_145_23","DOIUrl":"10.4103/jhrs.jhrs_145_23","url":null,"abstract":"<p><strong>Background: </strong>Patients with polycystic ovarian syndrome (PCOS) have unique characteristics depending on its phenotype. Therefore, prediction of controlled ovarian stimulation (COS) response and assisted reproductive technique (ART) outcome in these becomes challenging.</p><p><strong>Aims: </strong>To assess the outcomes of assisted reproductive technology (ART) in various polycystic ovary syndrome (PCOS) phenotypes and to evaluate the predictive value of anti-Mullerian hormone (AMH) and total testosterone on ART success. Clinical pregnancy rate (CPR) was measured as the primary outcome.</p><p><strong>Settings and design: </strong>This was a prospective observational study conducted at a tertiary care centre.</p><p><strong>Materials and methods: </strong>A total of 190 infertile women with PCOS (Rotterdam criteria) were enrolled and were subdivided into four phenotypes. Baseline screening and transvaginal scan were done. All patients underwent COS using antagonist protocol with recombinant follicle-stimulating hormone, and an agonist trigger was given for follicular maturation. One or two blastocysts were transferred in a frozen-thawed embryo transfer cycle. Luteal phase support was given with vaginal progesterone.</p><p><strong>Statistical analysis used: </strong>For quantitative variables, we employed the Kruskal-Wallis Test with post hoc Tukey's analysis. For continuous or ordinal variables, the Mann-Whitney U test was utilized. The analysis of categorical data was conducted using the Chi-square (χ2) test with SPSS 21 software.</p><p><strong>Results: </strong>Phenotype A was the most prevalent (37%). CPR was the highest in phenotype D (57.7%), followed by phenotype C (53.06%), A (43%) and B (36%). The mean serum AMH level was the highest in phenotype A (9.7 ± 4.3 ng/dL) and the lowest in phenotype B (5.9 ± 1.8 ng/dL). The mean total testosterone level was 103 ± 15.68 ng/mL in Type A, 109.46 ± 37.08 ng/mL in Type B and 48.52 ± 17.07 ng/ml in Type D.</p><p><strong>Conclusion: </strong>Phenotype D showed higher CPR and lower miscarriage rate compared to other phenotypes (not significant) and was associated with good clinical outcome. No correlation could be established with serum AMH, total testosterone levels and CPR.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"340-345"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Fluorescence <i>In situ</i> Hybridisation in the Diagnosis of Hidden Mosaicism in Egyptian Patients with Turner Syndrome.","authors":"Heba Mohamed Ossama, Soha Kholeif, Ghada Mohamed Elhady","doi":"10.4103/jhrs.jhrs_128_23","DOIUrl":"10.4103/jhrs.jhrs_128_23","url":null,"abstract":"<p><strong>Background: </strong>Turner syndrome (TS) is the most common chromosomal abnormality in females. The diagnosis of TS is based on karyotyping of 30 blood lymphocytes. This technique does not rule out tissue mosaicism or low-grade mosaicism in the blood. Because of the associated risk of gonadoblastoma, mosaicism is especially important in case this involves a Y chromosome.</p><p><strong>Aims: </strong>This study was set to determine the value of additional genetic studies such as fluorescent <i>in situ</i> hybridisation and the inclusion of buccal cells in search for mosaicism in TS patients.</p><p><strong>Settings and design: </strong>This cross-sectional, descriptive study was performed in Human Genetics Department, Medical Research Institute, Alexandria University.</p><p><strong>Materials and methods: </strong>Fluorescence <i>in situ</i> hybridisation technique was applied to lymphocyte cultures as well as buccal smears using centromeric probes for X and Y chromosomes. Genotype phenotype correlation was also evaluated.</p><p><strong>Statistical analysis used: </strong>Descriptive study where categorical variables were described using number and percentage and continuous variables were described using mean and standard deviation.</p><p><strong>Results: </strong>Fluorescence <i>in situ</i> hybridisation technique study detected hidden mosaicism in 60% of studied patients; 20% of patients had a cell line containing Y material, while 40% had variable degrees of X, XX mosaicism, and in the remaining 40% no second cell line was detected. Fluorescence <i>in situ</i> hybridisation study helped identify the origin of the marker to be Y in all patients. The introduction of an additional cell line helped in identifying mosaicism in patients with monosomy X. Virilisation signs were only observed among TS patients with Y cell line mosaicism. The clinical manifestations were more severe in patients with monosomy X than other mosaic cases.</p><p><strong>Conclusions: </strong>Molecular cytogenetic investigation for all suspected cases of TS should be considered for appropriate treatment plan and genetic counselling.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"286-298"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Effects of Ultra-low Oxygen Concentration during Extended Embryo Culture on <i>In vitro</i> Fertilisation Outcomes in Indian Women: A Retrospective Cross-sectional Study.","authors":"Deven Patel, R G Patel, Trupti Patel, Nikunj Patel, Naroda Maheshwari","doi":"10.4103/jhrs.jhrs_143_23","DOIUrl":"10.4103/jhrs.jhrs_143_23","url":null,"abstract":"<p><strong>Background: </strong>Amongst various other factors, oxygen (O2) concentration in embryo culture plays an important role in determining pregnancy outcomes in women undergoing in vitro fertilisation. Some studies have reported that lowering O2 levels in embryo culture provides better results.</p><p><strong>Aims: </strong>To explore the effects of low- and ultra-low- O2 concentrations (5% and 2%, respectively) in extended embryo culture on various outcome parameters of pregnancy.</p><p><strong>Settings and design: </strong>This was a retrospective cross-sectional study.</p><p><strong>Materials and methods: </strong>In this study 382 participants had their embryos cultured in varying O2 concentrations (5% or 2%), followed by either a fresh embryo transfer (ET) or frozen embryo transfer (FET). Outcomes such as pregnancy rate, implantation rate, abortion rate, twinning rate, and live birth rate were compared between the groups.</p><p><strong>Statistical analysis used: </strong>Chi square test was applied to compare the primary and secondary outcomes between different groups.</p><p><strong>Results: </strong>No significant differences were observed in pregnancy rate and implantation rate between 5% and 2% O2 groups, irrespective of their mode of ET. The abortion rate was significantly higher in 5% O2 group than in 2% group during FET (24.71% vs. 11.49%, <i>P</i> = 0.02). While the proportion of good-quality embryos was higher in 5% O2 group, these did not translate to better pregnancy outcomes. Additionally, embryos cultured in 2% O2 concentration had a significantly better implantation rate when they were transferred fresh rather than frozen (71.34% vs. 61.46%, <i>P</i> = 0.04). There were no other differences observed.</p><p><strong>Conclusion: </strong>Only marginal benefits were observed in switching human embryos to ultra-low O2 concentration after the initial days of culture.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"324-332"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Cycle Frozen Embryo Transfer: Evaluating Optimal Protocols for Preparation and Timing.","authors":"Kai N Holder, Jessica S Mormol, Jennifer B Bakkensen, Mary Ellen Pavone, Kara N Goldman, Chen Yeh, Lutfiyya N Muhammad, Lia A Bernardi","doi":"10.4103/jhrs.jhrs_125_23","DOIUrl":"10.4103/jhrs.jhrs_125_23","url":null,"abstract":"<p><strong>Background: </strong>While natural cycle frozen embryo transfer (NC-FET) is becoming increasingly common, significant practice variation exists in the use of ovulation induction medications, administration of ovulation trigger, and timing of embryo transfer without consensus as to the optimal protocol.</p><p><strong>Aims: </strong>The objective of this study is to evaluate the association of key aspects of the NC-FET protocol with implantation, pregnancy and live birth.</p><p><strong>Settings and design: </strong>This was a retrospective cohort study of blastocyst stage NC-FET cycles from October 2019 to July 2021 at a single academic fertility centre.</p><p><strong>Materials and methods: </strong>Protocols varied between cycles across three key parameters which were evaluated as primary predictors of cycle outcomes: (1) use of letrozole for mild ovarian stimulation/ovulation induction, (2) administration of exogenous ovulation trigger versus spontaneous luteinising hormone surge and (3) transfer timing based on ovulation trigger versus sequential progesterone monitoring. Primary outcomes included implantation rate, clinical pregnancy and ongoing pregnancy.</p><p><strong>Statistical analysis used: </strong>Generalised estimating equations were fitted to obtain adjusted odds ratios or rate ratios as appropriate with 95% confidence intervals for each outcome across the three primary predictors.</p><p><strong>Results: </strong>A total of 183 cycles from 170 unique patients were eligible for inclusion. The average implantation rate was 0.58, resulting in an overall clinical pregnancy and ongoing pregnancy rate of 59.0% and 51.4%, respectively. After adjusting for age at embryo freeze and history of a failed embryo transfer, there were no significant associations between any predictor and implantation rate, clinical pregnancy, ongoing pregnancy, or live birth.</p><p><strong>Conclusion: </strong>In NC-FET, a variety of preparation and timing protocols may lead to comparable cycle outcomes, potentially allowing for flexibility on the basis of patient and physician preference. These findings warrant validation in a larger, randomised trial.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"333-339"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Anabolic-Androgenic Steroids and Male Fertility: A Systematic Review and Meta-analysis.","authors":"Prashant Motiram Mulawkar, Pankaj N Maheshwari, Vineet Gauhar, Sumeet Gopal Agrawal, Taofiq Olayinka Mohammed, Abhishek Gajendra Singh, Gopal Ramdas Tak, Utsav Shailesh Shah, Deepali Parthsarthi Shukla, Deepali Mamankar","doi":"10.4103/jhrs.jhrs_90_23","DOIUrl":"10.4103/jhrs.jhrs_90_23","url":null,"abstract":"<p><strong>Background: </strong>Anabolic-androgenic steroids (AASs) are often used by men for bodybuilding and to improve sports performance. The use is not limited to professional competitive athletes, but many amateur men.</p><p><strong>Objective: </strong>The objective of this study was to assess and systematically review the effects of AAS on male fertility parameters, spermiogram, testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH) and to review reversibility and other morbidity impacting fertility.</p><p><strong>Methods: </strong>Eligibility criteria - We included studies mentioning data about adult males using supraphysiologic doses of AAS for sports performance or appearance enhancement, with comparison data from general population or matched controls if available reporting fertility parameters and sexual performance. Information sources - A systematic literature search was performed using PubMed, MEDLINE, EMBASE, Google Scholar and World of Science. Controlled clinical trials randomised or nonrandomised (if available), case series with or without matched controls, case reports, cross-sectional surveys, reports on follow-up of subjects caught in doping test and their fertility parameters when reported. Risk of bias/quality assessment - The quality assessment of the included studies was performed using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Included studies - Thirty-two studies were included. There were 12 cohort studies, 5 case-control studies, 9 cross-sectional surveys and 6 case reports. The study population comprised 9371 individuals, of which 2671 were AAS users. Synthesis of results - AAS users had reduced levels of FSH and LH than the naïve population. These levels remained low for 3-6 months after stopping AAS. One year after stopping AAS, the users and naïve population had insignificant differences in FSH and LH values. The total testosterone (TT) levels were comparable in users and naïve populations at baseline, 3 months and 6 months after stopping, but at 1 year, TT values were lower in AAS users. Sperm concentration in AAS users and naïve population was similar, but sperm motility was lower in AAS users. The testicular size was lower in AAS users. The erectile function improved with AAS use, but on withdrawal, there was decreased libido and erectile dysfunction. Most AAS users need additional medications to mitigate detrimental effects on fertility. Description of the effect - AAS use negatively impacted the gonadotrophin levels and had lower sperm motility and testicular size. Strength - Comprehensive review of 32 publications, study population of 9371 individuals, of which 2671 were AAS users, meta-analysis of reproductive hormones, semen parameters and testis size.</p><p><strong>Limitations: </strong>The limitations are small sample size of most of the studies, polypharmacy, lack of information on dosing and high heterogeneity.</p><p><strong>Interpretation: </strong>AAS use is d","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"268-285"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary.","authors":"Padma Rekha Jirge","doi":"10.4103/jhrs.jhrs_178_23","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_178_23","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"267"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining the Unexplained: Examining the Predictive Value of Semen Parameters, Sperm DNA Fragmentation and Metal Levels in Unexplained Infertility.","authors":"Navdeep Kaur Ghuman, Kamla Kant Shukla, Srividhya Nandagopal, Sunil Raikar, Shailendra Kumar, Priyanka Kathuria, Dinesh Choudhary, Poonam Elhence, Pratibha Singh","doi":"10.4103/jhrs.jhrs_140_23","DOIUrl":"10.4103/jhrs.jhrs_140_23","url":null,"abstract":"<p><strong>Background: </strong>There is ongoing research to find an optimum modality to predict male fertility potential.</p><p><strong>Aims: </strong>To compare the semen parameters, sperm DNA damage and seminal metal levels of Zinc, Lead and Aluminium among the male partners of couples with unexplained infertility and men with proven fertility.</p><p><strong>Settings and design: </strong>Prospective case-control study at a tertiary level teaching hospital.</p><p><strong>Materials and methods: </strong>One hundred male partners of couples with unexplained subfertility and 50 men with proven fertility were included in the study. Male partners of unexplained infertility couples and fertile men were compared for their semen parameters, sperm DNA Fragmentation Index (DFI) and seminal metal levels in semen.</p><p><strong>Statistical analysis used: </strong>Chi-square test, Student's <i>t</i>-test, sensitivity and specificity analysis, binomial logistic regression analysis.</p><p><strong>Results: </strong>Fertile men had statistically significantly higher mean progressive sperm motility than male partners of unexplained infertility (53.12 ± 9.89% vs. 44.81 ± 19.47%, <i>P</i> = 0.005). Semen volume and sperm concentration were comparable among the cases and control population. The mean sperm DFI was significantly lower among fertile men (10.83 ± 6.28 vs. 21.38 ± 10.28, <i>P</i> < 0.0001). Plotting the receiver-operating characteristic curve the threshold for discrimination was calculated to be 18% DFI. The sensitivity specificity and overall accuracy were 43%, 84% and 56.67%, respectively when the DFI cut-off was set at 18%. Zinc concentration in the semen had a strong positive correlation (Point Biserial correlation coefficient = 0.831) with fertility, whereas lead and aluminium had a moderate negative correlation.</p><p><strong>Conclusion: </strong>Conventional semen analysis had limited differentiating ability for unexplained infertility. The sperm DFI may be employed for explanatory purposes among couples with unexplained subfertility. A lower discriminatory threshold of DFI (18%) has better overall accuracy as opposed to a 30% cutpoint for unexplained subfertility. Among metals, Zinc was strongly correlated with fertility status.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"317-323"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling for present and future (2100) possible distribution of Anadolu Chestnut (Castanea sativa) in Anatolia","authors":"Ayşe Atalay Dutucu","doi":"10.14687/jhs.v20i4.6405","DOIUrl":"https://doi.org/10.14687/jhs.v20i4.6405","url":null,"abstract":"Climate is a factor that closely controls the forming of the geographical environment and human life. One of the most obvious reflections of this effect is seen on biodiversity. Especially plants are among the most fragile species that will be affected by the changes that may occur in climatic conditions. The aim of this study is to determine the current and future potential distribution areas of Anatolian Chestnut, which grows in Anatolia and forms an important species of temperate-humid forests. For this purpose, today's distribution data regarding the distribution of Anatolian chestnut in Anatolia and its surroundings were provided. Climate data with 2.5 arc-minutes/~5 km resolution covering the period 1970-2000 obtained from the WorldClim 2.1 database were used to determine the current suitable habitat areas of the species. MIROC6 model with 2.5 arc-minutes/~5 km resolution for determining suitable future habitat areas, Common Socio-Economic (SSP) SSP2-4.5, SSP5-8.5 scenarios included in IPCC 6th Report and WorldClim 2.1 database covering the period 2081-2100 climate projection data applied. As a result, it has been revealed that the Anatolian chestnut is grown on the humid slopes of the mountains facing north, especially in the Black Sea coastal zone, in the Marmara and partalla in the Aegean Regions. According to the projection results, it is expected that the \"suitable\" distribution areas for the species will decrease by 33.9% according to the SSP2-4.5 scenario and by 79.7% according to the SSP5-8.5 scenario. (Extended English summary is at the end of this document) Özet İklim coğrafi çevrenin şekillenmesini ve insan yaşamını çok yakından kontrol eden bir etmendir. Bu etkinin en belirgin yansımalarından biri biyoçeşitlilik üzerinde görülmektedir. Özellikle bitkiler iklim koşullarında meydana gelen değişkenliklere karşı en kırılgan türlerin başında gelmektedir. Bu çalışmanın amacı ılıman- nemli ormanların önemli bir türünü oluşturan Anadolu Kestanesi’ nin Anadolu’daki günümüz ve gelecekteki potansiyel yayılış alanlarını belirlemektir. Bu amaçla Anadolu Kestanesi’ nin Anadolu ve çevresindeki dağılımına ilişkin günümüz dağılış verileri temin edilmiştir. Türün günümüzdeki uygun habitat sahalarını belirlemek için WorldClim 2.1 veri tabanından temin edilen 1970-2000 periyodunu kapsayan 2.5 arc-dakika/~5 km çözünürlüklü iklim verileri kullanılmıştır. Gelecekteki uygun habitat sahalarının belirlenmesinde 2.5 arc-dakika/~5 km çözünürlükte MIROC6 modeli, IPCC 6. Raporunda yer alan Ortak Sosyo-Ekonomik (SSP) SSP2-4.5, SSP5-8.5 senaryoları ve WorldClim 2.1 veri tabanından elde edilen ve 2081-2100 dönemini kapsayan iklim projeksiyonu verisi kullanılmıştır. Sonuçta Anadolu Kestanesi’ nin günümüzde özellikle Karadeniz kıyı kuşağı olmak üzere Marmara ve kısmen de Ege Bölgelerinde dağların kuzeye bakan nemli yamaçlarında yetiştiği ortaya konmuştur. Projeksiyon sonuçlarına göre ise tür için “uygun” yayılış alanlarının SSP2-4.5 senaryosuna göre %33.9, SSP5-8","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135407417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}