Journal of Human Reproductive Sciences最新文献

{"title":"The Predictive Value of Serum Follicle-stimulating Hormone Level and Testicular Volume on the Outcome of Spermatozoa Retrieval from Testes in Men with Non-obstructive Azoospermia - A Retrospective Cohort Study.","authors":"Puvithra Thanikachalam, Gayatri Ravikuppan, Sowbarnika Arunkumar, Radha Pandiyan, Pandiyan Natarajan","doi":"10.4103/jhrs.jhrs_9_25","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_9_25","url":null,"abstract":"<p><strong>Background: </strong>Biological parenthood in men with azoospermia can be achieved only by successful surgical spermatozoa retrieval and utilising these spermatozoa to perform intracytoplasmic spermatozoon injection. Spermatozoa retrieval from testes (SPERT) involves removing seminiferous tubules in an attempt to retrieve spermatozoa in men with non-obstructive azoospermia (NOA). Testicular volume and serum follicle-stimulating hormone (FSH) levels are considered to be markers for predicting the success of spermatozoa retrieval from the testes.</p><p><strong>Aim: </strong>The aim of this study was to study the predictive value of serum FSH level and testicular volume on the outcome of SPERT in men with NOA.</p><p><strong>Settings and design: </strong>It is a retrospective cohort study of 26 men with NOA who underwent SPERT from 2008 to 2024 in a university-level teaching hospital.</p><p><strong>Materials and methods: </strong>The study population was divided into four groups based on the FSH levels (Group I: FSH: 2-10.9 mIU/mL [<i>n</i> = 10], Group II: FSH: 11-20.9 mIU/mL [<i>n</i> = 4], Group III: FSH: 21-30 mIU/mL [<i>n</i> = 8] and Group IV: FSH: >30 mIU/mL [<i>n</i> = 4]). A comparison of testicular volume and SPERT outcome was studied in the number of testes, in which SPERT was performed (<i>n</i> = 48) due to the differences in testicular volume in the same individual and also because only unilateral SPERT was performed in some patients. Patients were divided into three groups based on testicular volume (Group I: Testicular volume: 7-10 mL (<i>n</i> = 30), Group II: Testicular volume: 4-6 mL (<i>n</i> = 11) and Group III: Testicular volume: <3 mL (<i>n</i> = 7)].</p><p><strong>Statistical analysis used: </strong>The collected data were analysed using Chi-square test using SPSS software.</p><p><strong>Results: </strong>Our observations showed no correlation between successful SPERT and serum FSH levels or testicular volume. Based on the serum FSH level, the success rate of SPERT was 40%, 50%, 25% and 75% in Groups I, II, III and IV (<i>P</i> = 0.415). Similarly, based on the testicular volume groups, the success rates were 30%, 45% and 71% in Groups I, II and III (<i>P</i> = 0.118).</p><p><strong>Conclusion: </strong>In this study, we found that neither serum FSH level nor testicular volume could predict the success of spermatozoa retrieval using the SPERT technique in men with NOA.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Inguinal Swelling in a Young Female: An Unusual Presentation of MURCS.","authors":"Navdeep Kaur, Bhawna Satija, Sayani Mahal, Shubham Arora","doi":"10.4103/jhrs.jhrs_190_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_190_24","url":null,"abstract":"<p><p>Inguinal hernia in females is an uncommon entity. While most patients present in infancy or early in childhood, only a few cases are diagnosed in adulthood. Most cases of inguinal hernia have small bowel or omentum as its content. Herniation of the ovary or fallopian tube is rare. In our case, an 18-year-old female presented to the outpatient department with unilateral inguinal swelling, which on imaging was found to be ovarian inguinal herniation. This prompted further evaluation. There was an associated absence of the uterus and left kidney, and congenital block vertebrae involving the cervical spine. On probing it was found that she had primary amenorrhoea with normal secondary sexual characteristics. All the findings led to the diagnosis of Mayer Rokitansky Kuster Hauser type II or Mullerian duct aplasia renal agenesis cervicothoracic somite dysplasia (MURCS) with unilateral inguinal ovarian herniation. Mullerian duct aplasia renal agenesis cervicothoracic somite dysplasia (MURCS) present a challenge as they require a multidisciplinary team including gynaecologist, surgeon and psychologist to preserve the ovarian function and help the patient counsel regarding the reproductive outcome and wade through the associated emotional stress.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Letrozole in Improving Semen Parameters of Subfertile Men with Moderate-to-Severe Oligoasthenoteratozoospermia: A Placebo-controlled Randomised Trial.","authors":"Pallavi Ullur, N S Kubera, Soliappappan Manikandan, Nivedita Nanda, Sujatha Venkatraman, Anusuya Ram","doi":"10.4103/jhrs.jhrs_160_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_160_24","url":null,"abstract":"<p><strong>Background: </strong>Currently lack of consensus regarding the medical treatment of men with Oligoasthenoteratozoospermia (OATS). Letrozole is an aromatase inhibitor and may improve semen quality by stimulating hormone synthesis and spermatogenesis. There is lack of evidence on the efficacy and safety of letrozole as therapy for male infertility.</p><p><strong>Aim: </strong>To study the efficacy of letrozole in improving semen parameters, hormonal profile of participants with moderate-to-severe OATS and its side effects.</p><p><strong>Settings and design: </strong>Randomised double-blinded placebo-controlled trials conducted in a tertiary care centre conducted between August 2021 and July 2023. Men with abnormal semen analysis reports between the age group of 21 and 45 years with moderate-to-severe OATS visiting the male infertility clinic were enrolled.</p><p><strong>Materials and methods: </strong>Fifty-four men were randomised into two groups. Twenty-eight men in A (intervention group) received letrozole, and 24 men in Group B (control group) received a placebo after written informed consent. After 3 months, semen analysis and hormonal parameters were studied.</p><p><strong>Statistical analysis used: </strong>Data analysis was performed using SPSS version 19 (IBM). Associations between categorical variables in two groups were analysed using the Chi-square test or Fisher's exact test. Continuous variables were compared using the Mann-Whitney test, and independent Students' <i>t</i>-test and pre- and post-treatment comparisons of continuous variables were assessed using a paired <i>t</i>-test or Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Total sperm count increased by 4.4 (2.8, 8.8) million per ejaculate, sperm concentration by 3.2 (1, 4.4) million/mL and progressive motility by 5.8 ± 7.3% compared to the placebo group, which was statistically significant (<i>P</i> = 0.001). The use of letrozole had minor side effects like headache and nausea. Letrozole use in men with OATS showed a significant improvement in follicle-stimulating hormone by 6.8 ± 5.5 mIU/mL, luteinising hormone by 6.3 ± 3.3 IU/L, testosterone by 193.3 ± 130 ng/dL, with <i>P</i> value of 0.001 and significant fall in oestradiol by 17.6 ± 7.9 pg/mL overall improving T/E ratio by 18.4 ± 8.8.</p><p><strong>Conclusion: </strong>Letrozole use may result in improving semen parameters in men with moderate-to-severe OATS. However, these findings need to be validated in larger trials.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary.","authors":"Mohan S Kamath","doi":"10.4103/jhrs.jhrs_49_25","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_49_25","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Factors Associated with Attrition in a Lifestyle Intervention Trial amongst Women with Polycystic Ovarian Syndrome Desiring Fertility - An Interview based Study.","authors":"Mary Ann, Chinta Parimala, Parisuddharao Koduri, Aleyamma Thayparmbil Kunjummen, Mohan Shashikant Kamath","doi":"10.4103/jhrs.jhrs_173_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_173_24","url":null,"abstract":"<p><strong>Background: </strong>Previous studies exploring the barriers to weight management have suggested psychological, social and logistical barriers were important reasons for high attrition and non-adherence.</p><p><strong>Aim: </strong>The aim of this study was to assess the possible reasons for high attrition and non-adherence to lifestyle interventions in a trial setting amongst women with polycystic ovarian syndrome (PCOS) who wish to conceive.</p><p><strong>Setting and design: </strong>The study was conducted in a tertary level hospital and employed a qualitative study paradigm.</p><p><strong>Materials and methods: </strong>The study was nested within a feasibility study that explored the possibility of conducting lifestyle interventional trials in women with PCOS who wish to conceive. Eligible participants who refused participation in the trial were interviewed under three major categories: refusal before randomisation, refusal after randomisation and non-adherence.</p><p><strong>Statistical analysis used: </strong>Thematic analysis was used to analyse textual data.</p><p><strong>Results: </strong>The participants considered PCOS as a 'fairly common' condition and did not perceive the need to address the impact of PCOS on their health. The second recurring theme was the perception of being overweight as 'healthy' and 'normal' and downplaying lifestyle changes to focus only on fertility treatment for achieving pregnancy. Finally, the decision to pursue weight loss or to discontinue it seems to be a shared decision making among family memebers which limits the ability of the clinicians and healthcare practitioners to effectively deliver appropriate advice on lifestyle interventions.</p><p><strong>Conclusion: </strong>The current findings would help in planning and designing adequately powered randomised controlled trials to evaluate the impact of lifestyle intervention in women with PCOS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Anxiety and Perceived Stress with <i>In vitro</i> Fertilization Outcomes in Infertile Women: A Cross-sectional Study.","authors":"Sara Abdoli, Amir Hossein Gholami, Seyedeh Zahra Masoumi, Roya Najafi-Vosough, Mozhdeh Azimi, Ensiyeh Jenabi, Sahar Aliabadi, Ali Reza Soltanian, Ali Ghaleiha, Shamim Pilehvari","doi":"10.4103/jhrs.jhrs_168_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_168_24","url":null,"abstract":"<p><strong>Background: </strong>The studies have shown that the effects of psychological distress on the outcome of <i>in vitro</i> fertilization (IVF) treatment are unclear, and there is still no conclusive empirical evidence that lower anxiety levels lead to better outcomes in assisted reproductive technique treatments.</p><p><strong>Aim: </strong>the present study was conducted to investigate the impact of perceived anxiety and stress on the outcome of IVF in infertile women in Western Iran.</p><p><strong>Settings and design: </strong>The current study is a cross-sectional study.</p><p><strong>Materials and methods: </strong>This study was conducted on infertile women who were candidates for IVF and visited the infertility center at Fatemiyeh Hospital in Hamadan City in the west of Iran from 8 July 2023, to 15 March 2024. The questionnaires were demographic and midwifery characteristics, the Spielberger State-Trait Anxiety Inventory and Perceived Stress Scale-14.</p><p><strong>Statistical analysis used: </strong>All statistical analyses were performed in SPSS software at a significance level of 0.05.</p><p><strong>Results: </strong>The stress was significantly associated with metaphase II eggs (<i>r</i> = -0.487), and the number of transferred embryos based on grade (<i>r</i> = -0.562), duration of marriage (<i>r</i> = 0.628), duration of infertility (<i>r</i> = 0.595) and duration of treatment (<i>r</i> = 0.595). There was no significant association between stress and endometrial thickness (<i>P</i> = 0.189). In addition, the anxiety was significantly associated with age (<i>r</i> = 0.509), husband›s age (<i>r</i> = 0.436), endometrial thickness (<i>r</i> = -0.173), metaphase II eggs (<i>r</i> = -0.570), and the number of ‎transferred embryos based on grade (<i>r</i> = -0.610), duration of marriage (<i>r</i> = 0.604), duration of infertility (<i>r</i> = 0.592) and duration of treatment (<i>r</i> = 0.604).</p><p><strong>Conclusion: </strong>Mean stress and anxiety in infertile women were significantly lower in infertile women with successful IVF. Stress was significantly associated with age, spouse's age, metaphase stage oocytes, embryo grade, duration of marriage and infertility and duration of treatment.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary.","authors":"Mohan S Kamath","doi":"10.4103/jhrs.jhrs_191_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_191_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"223"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrative Approach to Precision Pre-implantation Genetic Diagnosis by Investigating Single-cell Sequencing, Polygenic Risk Assessment, Artificial Intelligence-guided Embryo Selection and Genome Editing in Embryos with COL4A1 c.1537G>A Mutation.","authors":"Muhammed Ali Siham","doi":"10.4103/jhrs.jhrs_145_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_145_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"292-293"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Long Non-coding RNA FAS-AS1/FAS/Caspase3 Axis in Endometriosis: A Cross-sectional Study.","authors":"Amir Hossein Shayanfard, Zivar Salehi, Farhad Mashayekhi, Ziba Zahiri","doi":"10.4103/jhrs.jhrs_92_24","DOIUrl":"10.4103/jhrs.jhrs_92_24","url":null,"abstract":"<p><strong>Background: </strong>An increasing number of studies have demonstrated that excessive proliferation and apoptosis play a pivotal role in the development of endometriosis.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the expression of long non-coding RNA (lncRNA) FAS-AS1, FAS, soluble Fas (sFas) and caspase-3 in patients with different stages of endometriosis.</p><p><strong>Setting and design: </strong>The design of the study was a cross-sectional study.</p><p><strong>Materials and methods: </strong>The relative expression of lncRNA FAS-AS1 and FAs gene was evaluated by the quantitative real-time polymerase chain reaction in 60 ectopic endometrial samples from women with endometriosis in relation to 85 normal endometrial tissues from healthy women, whereas the protein level of sFAs in the peritoneal fluid samples and cleaved caspase-3 in ectopic and normal endometrial tissue samples were determined using the enzyme-linked immunosorbent assay and western blot, respectively. Furthermore, <i>in silico</i> analyses were performed to investigate protein-protein interactions as well as molecular function and cellular location of selected proteins.</p><p><strong>Statistical analysis used: </strong>The student's <i>t</i>-test was used to analyse the difference between the means of the two groups.</p><p><strong>Results: </strong>The expression of FAS and sFas increased in endometriosis tissues as compared to the control group (<i>P</i> < 0.05). However, lncRNA FAS-AS1 and cleaved caspase-3 decreased in ectopic endometrial tissues compared to normal endometrial tissues and low lncRNA FAS-AS1 expression was correlated with disease stages. In addition, the <i>in silico</i> analysis revealed the importance of FAS/caspase3 in the biological processes involved in the development of endometriosis.</p><p><strong>Conclusion: </strong>The current study suggests that lncRNA FAS-AS1 may function as an ectopic endometriotic suppressor. Moreover, the results showed that severity of endometriosis is also closely correlated with the expression of lncRNA FAS-AS1 and sFAS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"246-254"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Predictors of Response to Ovulation Induction Using Letrozole in Women with Polycystic Ovary Syndrome: A Prospective Cohort Study.","authors":"Shanti Tholiya, Archana Kumari, Reeta Mahey, Mani Kalaivani, Hem Chandra Sati, Mona Sharma, Aarthi K Jayraj, Neena Malhotra","doi":"10.4103/jhrs.jhrs_133_24","DOIUrl":"10.4103/jhrs.jhrs_133_24","url":null,"abstract":"<p><strong>Background: </strong>Ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS) remains challenging, and several biomarkers have been evaluated for their ability to predict ovulation. The predictive ability of candidate biomarkers, particularly with letrozole-based therapy in infertile PCOS women, remains inconclusive as it is yet to be evaluated in a prospective study.</p><p><strong>Aim: </strong>To assess the role of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinising hormone (LH)/FSH ratio, testosterone and free androgen index (FAI) as predictors of ovarian response to letrozole-based OI therapy during OI cycles in infertile women with PCOS from North India.</p><p><strong>Settings and design: </strong>A prospective cohort study was conducted in a tertiary care hospital in north India.</p><p><strong>Materials and methods: </strong>The study enrolled 80 infertile women with PCOS, diagnosed according to the Rotterdam criteria. OI was conducted using letrozole with or without human menopausal gonadotropin. Baseline endocrine and metabolic parameters, including serum AMH, FSH, LH, testosterone and FAI levels, were measured using ELISA or chemiluminescence methods on day 2 of the menstrual cycle. Follicular response to OI was monitored by transvaginal ultrasonography.</p><p><strong>Statistical analysis used: </strong>Descriptive and inferential statistical analyses were conducted, including Mann-Whitney, Kruskal-Wallis, Independent <i>t</i>-test, analysis of variance, Fisher's exact test and receiver operating characteristic curve analysis. Data were processed using Microsoft Excel and analysed with SPSS software, version 25.0. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Of 80 women enrolled, 74 responded to letrozole-based OI, while six were non-responders. Body mass index (BMI), serum testosterone and pre-treatment AMH levels significantly correlated with follicular response, with higher values linked to reduced responsiveness. The likelihood ratio+ (95% confidence interval) was 3.32 (2.45-5.06) for AMH, 1.97 (1.03-3.78) for BMI and 1.93 (1.22-3.08) for testosterone. The odds ratio for AMH was 2.88 (1.01-8.21) and 1.25 (1.02-1.53) for BMI. An AMH cut-off of ≤16.43 ng/mL predicted ovarian response with an AUC of 0.88.</p><p><strong>Conclusions: </strong>Pre-treatment AMH levels, along with BMI and serum testosterone, are significant predictors of ovarian response to letrozole-based OI in infertile women with PCOS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"240-245"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}