Journal of Human Reproductive Sciences最新文献

{"title":"Editorial Commentary.","authors":"Padma Rekha Jirge","doi":"10.4103/jhrs.jhrs_178_23","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_178_23","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"267"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining the Unexplained: Examining the Predictive Value of Semen Parameters, Sperm DNA Fragmentation and Metal Levels in Unexplained Infertility.","authors":"Navdeep Kaur Ghuman, Kamla Kant Shukla, Srividhya Nandagopal, Sunil Raikar, Shailendra Kumar, Priyanka Kathuria, Dinesh Choudhary, Poonam Elhence, Pratibha Singh","doi":"10.4103/jhrs.jhrs_140_23","DOIUrl":"10.4103/jhrs.jhrs_140_23","url":null,"abstract":"<p><strong>Background: </strong>There is ongoing research to find an optimum modality to predict male fertility potential.</p><p><strong>Aims: </strong>To compare the semen parameters, sperm DNA damage and seminal metal levels of Zinc, Lead and Aluminium among the male partners of couples with unexplained infertility and men with proven fertility.</p><p><strong>Settings and design: </strong>Prospective case-control study at a tertiary level teaching hospital.</p><p><strong>Materials and methods: </strong>One hundred male partners of couples with unexplained subfertility and 50 men with proven fertility were included in the study. Male partners of unexplained infertility couples and fertile men were compared for their semen parameters, sperm DNA Fragmentation Index (DFI) and seminal metal levels in semen.</p><p><strong>Statistical analysis used: </strong>Chi-square test, Student's <i>t</i>-test, sensitivity and specificity analysis, binomial logistic regression analysis.</p><p><strong>Results: </strong>Fertile men had statistically significantly higher mean progressive sperm motility than male partners of unexplained infertility (53.12 ± 9.89% vs. 44.81 ± 19.47%, <i>P</i> = 0.005). Semen volume and sperm concentration were comparable among the cases and control population. The mean sperm DFI was significantly lower among fertile men (10.83 ± 6.28 vs. 21.38 ± 10.28, <i>P</i> < 0.0001). Plotting the receiver-operating characteristic curve the threshold for discrimination was calculated to be 18% DFI. The sensitivity specificity and overall accuracy were 43%, 84% and 56.67%, respectively when the DFI cut-off was set at 18%. Zinc concentration in the semen had a strong positive correlation (Point Biserial correlation coefficient = 0.831) with fertility, whereas lead and aluminium had a moderate negative correlation.</p><p><strong>Conclusion: </strong>Conventional semen analysis had limited differentiating ability for unexplained infertility. The sperm DFI may be employed for explanatory purposes among couples with unexplained subfertility. A lower discriminatory threshold of DFI (18%) has better overall accuracy as opposed to a 30% cutpoint for unexplained subfertility. Among metals, Zinc was strongly correlated with fertility status.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"317-323"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Is There a Relationship between Serum AntiMullerian Hormone Levels and Abortion Rates in Patients Who Received <i>In vitro</i> FertilisationEmbryo Transfer Cycles?","authors":"","doi":"10.4103/0974-1208.392250","DOIUrl":"10.4103/0974-1208.392250","url":null,"abstract":"<p><p>[This corrects the article on p. 57 in vol. 16, PMID: 37305769.].</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"366"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Measurement of Fertility-related Quality of Life across Gender in Primary Infertile Couples.","authors":"Amita Kumari, Afreen Begum H Itagi, V Bhargava Reddy Kanchi, Vijayan Sharmila, Satish Pundlik Dipankar","doi":"10.4103/jhrs.jhrs_65_23","DOIUrl":"10.4103/jhrs.jhrs_65_23","url":null,"abstract":"<p><strong>Background: </strong>Infertility is a crucial global public health issue that affects millions of people of reproductive age. Fertility-related stress can negatively impact infertile couples' quality of life (QoL).</p><p><strong>Aims: </strong>This study aimed to assess and compare the psychometric properties of fertility QoL between primary infertile couples' male and female partners.</p><p><strong>Settings and design: </strong>This cross-sectional study included 114 primary infertile couples visiting the Andrology Laboratory referred from the Gynaecology and Obstetrics Department, AIIMS, Patna.</p><p><strong>Materials and methods: </strong>Data were collected using the Fertility QoL (FertiQoL) tool, an internationally validated questionnaire to measure the reproductive QoL, demographic information and medical history. The FertiQoL questionnaire responses were recorded and analysed.</p><p><strong>Statistical analyses used: </strong>Statistical analyses used were performed using the SPSS 20.0 version. Descriptive statistics, Kolmogorov-Smirnov test, Cronbach's alpha and Student's independent <i>t</i>-tests were used. Statistical significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>In our study, the overall estimated Cronbach's α was 0.83, and males had a significantly better fertility-related QoL in all domains of the FertiQoL, such as emotional (<i>P</i> < 0.000), mind-body (<i>P</i> < 0.000), social (<i>P</i> < 0.004) and tolerability (<i>P</i> < 0.000), except relational and environmental domains, which were lower in them. However, between the groups, the relational domain was significant (0.000) and the environmental domain was non-significant (0.592). Overall, males had a significantly better total core score, total treatment score and overall total FertiQoL score, while females had lower scores.</p><p><strong>Conclusion: </strong>Amongst infertile couples, the reproductive QoL was poorer in females than in males. Our study suggests psychological counselling and mental support for females during infertility management.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"346-351"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Cervical Ectopic Pregnancy: A Multidisciplinary Approach Utilising Uterine Artery Embolisation and Hysteroscopic Resection.","authors":"Sangam Jha, B Jafeesha","doi":"10.4103/jhrs.jhrs_119_23","DOIUrl":"10.4103/jhrs.jhrs_119_23","url":null,"abstract":"<p><p>Cervical ectopic pregnancy (CEP) is a rare and challenging condition that requires prompt management to prevent complications. We present a case of a 27-year-old woman with a history of prior uterine surgeries who presented with vaginal spotting. Ultrasonography revealed an empty uterine cavity and a growing gestational sac with a viable foetus in the cervical canal. Despite methotrexate therapy, her beta-human chorionic gonadotropin hCG levels continued to rise, necessitating an alternative treatment approach. Bilateral uterine artery embolisation (UAE) was performed to reduce the risk of haemorrhage before hysteroscopic resection of the pregnancy. The combined approach of UAE and hysteroscopic resection successfully managed the CEP, leading to a favourable outcome. This case highlights the importance of early detection, tailored interventions and multidisciplinary collaboration in the management of CEP. UAE, in conjunction with hysteroscopic resection, offers a promising treatment option for CEP, minimising complications and preserving reproductive health.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"16 4","pages":"358-361"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between total vertical jump load and block performance in elite volleyball players: Position-specific analysis","authors":"Mehmet Görkem İşgüzar, Kadir Keskin, Fatma Tokat, Serdar Uslu","doi":"10.14687/jhs.v20i3.6401","DOIUrl":"https://doi.org/10.14687/jhs.v20i3.6401","url":null,"abstract":"Aim: The study aimed to examine the relationship between total load jumps and negative block performance of elite male volleyball players. Method: During the research, 18 elite volleyball athletes were monitored, composed of 7 middle players, 8 spikers, and 3 opposite players. The total vertical jump and block performance of volleyball players were assessed during 23 demo matches completed in routine training sessions. The tracking of vertical jump count was facilitated by employing a vert belt, while the assessment of block performance relied on the application of Data Volley 4 Pro software. The statistical analysis of the data was conducted using the SPSS 22.0 package program for Windows. The Spearman correlation test was applied to assess the relationship between jump load and block performance. Results: A negative, weak, and significant relationship was found between vertical jump load and ineffective block (r=-,206; p<0,05) and a weak but insignificant relationship for block error (r=,100; p>0,05) for middle players. A positive, insignificant relationship was found between vertical jump load and block error (r=,007; p>0,05), and a negative, insignificant, for the ineffective block (r=-,079; p>0,05) for spikers. A positive, insignificant relationship between total jump load and ineffective block (r=,054; p>0,05), and block error (r=,027; p>0,05). Conclusion: Across all players, the findings suggest that the total jump load is not significantly related to either block errors or ineffective blocks. The positive correlations observed between jump load and both block errors and ineffective blocks are not statistically significant for the entire group.","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135961630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the perceptions of physical education teachers towards inclusive students through metaphors","authors":"Ramazan Küçükahmetoğlu, Ekrem Levent İlhan","doi":"10.14687/jhs.v20i36399","DOIUrl":"https://doi.org/10.14687/jhs.v20i36399","url":null,"abstract":"The aim of this research is to determine the perceptions of physical education teachers towards inclusion students in physical education lesson through metaphor. Phenomenology pattern, one of the qualitative research patterns, was used in this research and 95 physical education teachers working in secondary schools in Konya province participated in the 2022-2023 academic year. From the teachers who participated in the research in the semi-structured form used as a data collection tool, ‘’Inclusive students in physical education class are for me ..... it's like. Because ........’’ they were asked to complete the sentence. Data obtained from the teachers' responses were analyzed according to the content analysis approach. Within the scope of the research, it was determined that physical education teachers produced 95 metaphors related to inclusion students. The metaphors produced were examined under 8 categories as ‘’a source of uncertainty and anxiety’’, ‘’a tool that provides complementary and equality’’, ‘’a difficult, exhausting and patience-demanding structure‘’, ‘’an individual that requires expertise’’, ‘’a tool for discovery and innovation’’, ‘’a source of happiness’’, ‘’a fragile structure’’ and ‘’individuals who are relegated to the background’’. When the categories were examined, it was found that the most metaphors were in the category of inclusion students as a means of discovery and innovation, and the least metaphors were in the category of inclusion students as individuals who were relegated to the background. As a result of the research, it was found that physical education teachers had positive perceptions towards inclusion students in the metaphors they developed for inclusion students. (Extended English summary is at the end of this document) Özet Bu araştırmanın amacı beden eğitimi öğretmenlerinin beden eğitimi dersinde kaynaştırma öğrencilerine yönelik algılarını metafor yoluyla belirlemektir. Nitel araştırma desenlerinden olgu bilim deseninin kullanıldığı araştırmaya 2022-2023 eğitim öğretim yılında Konya ilindeki ortaokullarda görev yapan 95 beden eğitimi öğretmeni katılmıştır. Veri toplama aracı olarak kullanılan yarı yapılandırılmış formda araştırmaya katılan öğretmenlerden ‘’Beden eğitimi dersinde kaynaştırma öğrencileri benim için ….. gibidir. Çünkü ……..’dır.’’ cümlesini tamamlamaları istenmiştir. Öğretmenlerin yanıtlarından elde edilen veriler içerik analizi yaklaşımına göre çözümlenmiştir. Araştırma kapsamında beden eğitimi öğretmenlerinin kaynaştırma öğrencilerine ilişkin 95 adet metafor ürettikleri belirlenmiştir. Üretilen metaforlar ‘’belirsizlik ve endişe kaynağı’’, ‘’tamamlayıcı ve eşitliği sağlayan bir araç’’, ‘’zor, yorucu ve sabır gerektiren yapı’’, ‘’uzmanlık gerektiren bir birey’’, ‘’keşfetme ve yenilik aracı’’, ‘’mutluluk kaynağı’’, ‘’kırılgan bir yapı’’ ve ‘’geri plana atılan bireyler’’ şeklinde 8 kategori altında incelenmiştir. Kategoriler incelendiğinde en fazla metaforun keşfetme ve yenilik aracı olarak ","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"168 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135151511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compassion fatigue and psychological resilience in nurses: A mixed method study","authors":"Nihan Yalçıner Durgu, Hilal Aydoğdu Durmuş","doi":"10.14687/jhs.v20i3.6400","DOIUrl":"https://doi.org/10.14687/jhs.v20i3.6400","url":null,"abstract":"Aim: The aim of this study is to determine the level and factors affecting nurses' compassion fatigue, the relationship between compassion fatigue and psychological resilience and to examine the causes of high and low levels of compassion fatigue and to reveal the factors that cause the situation. Method: An explanatory design, one of the mixed method designs, was used. In the quantitative part of the study, the Compassion Fatigue-Short Scale and the Psychological Resilience Scale were applied to 56 nurses. Face-to-face in-depth interviews were conducted with three nurses with the highest and lowest scores on compassion fatigue. Analysis of quantitative data was made t-test, ANOVA and post-hoc tests; analysis of qualitative data was made descriptive analysis. Findings: According to the quantitative results of the study, nurses who are satisfied with their profession and the department they work in have lower levels of compassion fatigue. In addition, there is a weak negative correlation between compassion fatigue and psychological resilience total scores. According to the qualitative results, while giving care to a patient in need, nurses feel the desire to help, sadness and helplessness. Caring for these patients results in psychological fatigue, psychological trauma, feeling of emptiness, sympathy, and happiness due to positive feedback. Witnessing the helplessness of patients, sudden/young deaths, devaluation, patients with bad prognosis and dissatisfied patients are among the situations that trigger compassion fatigue. Nurses cope with compassion fatigue by participating in social activities, taking leave, meditating, and thinking that it is their duty. Conclusions: Nurses are a professional group that experiences compassion fatigue intensely due to exposure to traumas of patients. It is recommended to create environments and conditions where nurses and nurses can express their intense emotions, to establish and maintain the consultation-liaison psychiatry system in hospitals, to create conditions that will increase professional satisfaction, to increase awareness of compassion fatigue, and to create programs to prevent compassion fatigue. Aim: The aim of this study is to determine the level and factors affecting nurses' compassion fatigue, the relationship between compassion fatigue and psychological resilience and to examine the causes of high and low levels of compassion fatigue and to reveal the factors that cause the situation. Method: An explanatory design, one of the mixed method designs, was used. In the quantitative part of the study, the Compassion Fatigue-Short Scale and the Psychological Resilience Scale were applied to 56 nurses. Face-to-face in-depth interviews were conducted with three nurses with the highest and lowest scores on compassion fatigue. Analysis of quantitative data was made t-test, ANOVA and post-hoc tests; analysis of qualitative data was made descriptive analysis. Findings: According to the quantitative results ","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135152933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of matters to technology and determination of affecting factors","authors":"Yasemin Aydın Kartal, Büşra Hızlıol, Aleyna Bulut, Sema Aker","doi":"10.14687/jhs.v20i3.6396","DOIUrl":"https://doi.org/10.14687/jhs.v20i3.6396","url":null,"abstract":"Aim: This study was conducted out to determine the attitudes of midwives working in a public hospital towards technology and the factors affecting it. Materials and Methods: The sample of the study, which was conducted in a descriptive design, consisted of 112 midwives actively working in a public hospital (Participation Rate: 82%). The data were collected with the \"Personal Information Form\" and the \"Attitudes Towards Technology Scale (ATTS)\". Results: It was determined that the average age of the midwives participating in the study was 27.14±4.95 (min: 21, max: 48) and 76.8% of the participants were undergraduate graduates. It was determined that 58% of the midwives worked between 1-5 years. It was determined that 60.7% of the participants partially benefited from technological devices while working in the clinic, while 83% had difficulty using technological devices. In the clinic, most monitors (91.1%), blood pressure and glucometer (91.1%) are mostly used for purposes such as following laboratory information (83%), entering or exiting materials (77.7%), drug tracking (68.8%) and midwifery care registration (63.4%). It was determined that 95.5%, digital thermometer (82.1%), computer (95.5%) and similar technological devices were used. It was found that problems such as connection/power supply interruption (69.6%) and slow system operation (89.3%) were frequently encountered while using these devices. The total score of midwives in ATTS was determined as 136.04±24.64. When the attitudes of midwives towards technology are evaluated in terms of different variables; It was determined that variables such as education level, clinic worked, years of work and benefiting from technological devices in the institution significantly differed the total score of ATTS. Conclusion: It was identified that the attitudes of midwives towards technology were positive and affected by many variables. It is recommended to organize in-service trainings and certificate programs to ensure the integration of current technologies in midwifery care. (Extended English summary is at the end of this document) Özet Amaç: Bu çalışma bir kamu hastanesinde çalışan ebelerin teknolojiye ilişkin tutumları ve etkileyen faktörlerin belirlenmesi amacıyla yürütüldü. Gereç ve Yöntem: Tanımlayıcı desende yürütülen araştırmanın örneklemini bir kamu hastanesinde aktif olarak görev yapan 112 ebe oluşturdu (Katılım Oranı: %82). Veriler “Kişisel Bilgi Formu” ve “Teknolojiye Karşı Tutum Ölçeği (TKTÖ)” ile toplandı. Bulgular: Araştırmaya katılan ebelerin yaş ortalamasının 27.14±4.95 (min: 21, max:48) olduğu ve katılımcıların %76.8’inin lisans mezunu olduğu saptandı. Ebelerin, %58’inin çalışma sürelerinin 1-5 yıl arasında değiştiği belirlendi. Katılımcıların, %60.7’sinin klinikte çalışırken teknolojik cihazlardan kısmen faydalandığı tespit edilirken, %83’ünün ise teknolojik aletlerden yararlanırken zorluk yaşadığı saptandı. Klinikte, çoğunlukla laboratuvar bilgilerini takip etme (%83), malzeme gi","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135258675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An alternative approach for daily perineal care of patients with indwelling urinary catheterization: Photodynamic inactivation with cationic porphyrin derivatives","authors":"Ayşe Akbıyık, Selçuk Kaya, Nermin Topaloğlu Avşar, Hüseyin Taşlı, Vildan Alptüzün, Sülünay Parlar Çoşkun","doi":"10.14687/jhs.v20i3.6395","DOIUrl":"https://doi.org/10.14687/jhs.v20i3.6395","url":null,"abstract":"Background: Catheter-associated urinary tract infections (CAUTI) constitute a significant portion of healthcare-associated infections. Using antiseptic for routine daily perineal care of patients with IUC may reduce CAUTIs. Aim: This study aimed to examine antimicrobial photodynamic inactivation (aPDI) against clinical isolates for use in the daily perineal care of patients with IUC. In addition, it was also aimed to compare the antimicrobial activities of aPDI and 0.1% chlorhexidine gluconate. Methods: In this in-vitro study, cationic porphyrin derivatives (CPDs) were used as photosensitizers in the experiments. CPDs, named PM, PE, PN, and PL were synthesized by the researchers. A diode laser device emitting light with a wavelength of 450 nm (blue light) was used as the light source. Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Klebsiella pneumoniae with multidrug-resistant (MDR) properties and Candida albicans were used. Photosensitizer (PS), aPDI, light (L), and control (C) groups in aPDI experiments; control (C) and chlorhexidine gluconate 0.1% groups were used in the chlorhexidine gluconate experiments. Survival was calculated based on CFU/mL in the control group. Results: In experiments, combinations of 25 J/cm² with 6.25 and 3.125 µM PM, PE reduced E. coli, K. pneumoniae, MRSA, and C. albicans survival in the range of 8.70 to 11.53 log₁₀. In aPDI experiments performed with 6.25 and 3.125 µM PN and PL concentrations at the same energy density, reductions in the range of 4.41 to 0.17 log₁₀ were observed in all four clinical isolates. In experiments where 1.5625 µM concentration was used, survival decreased in the range of 8.29 to 10.87 log₁₀ in PM and PE, while antimicrobial activity was limited in PN and PL. In the 0.1% chlorhexidine gluconate experiments, the survival reduction in all four clinical isolates ranged from 8.87 to 10.24 log₁₀. Conclusion: For PM and PE, a very strong aPDI was obtained in C. albicans, E.coli, K. pneumoniae, and MRSA at low concentrations and energy density. The same antimicrobial activity was found in experiments using 0.1% chlorhexidine gluconate. In this context, we would like to inform you that aPDI to be performed with a combination of 25 J/cm² at 6.25 and 3.125 µM concentrations of PM and PE has the potential to be an antiseptic in the daily perineal care of patients with IUC.","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135258799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}