Journal of Fungi最新文献

{"title":"Characterization of a New Hsp110 Inhibitor as a Potential Antifungal.","authors":"Cancan Sun, Yi Li, Justin M Kidd, Jizhong Han, Liangliang Ding, Aaron E May, Lei Zhou, Qinglian Liu","doi":"10.3390/jof10110732","DOIUrl":"10.3390/jof10110732","url":null,"abstract":"<p><p>Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protein homeostasis in eukaryotes. Fungal Hsp110s have emerged as a promising target for innovative antifungal strategies. Notably, 2H stands out as a promising candidate in the endeavor to target Hsp110s and combat fungal infections. Our study reveals that 2H exhibits broad-spectrum antifungal activity, effectively disrupting the in vitro chaperone activity of Hsp110 from <i>Candida auris</i> and inhibiting the growth of <i>Cryptococcus neoformans</i>. Pharmacokinetic analysis indicates that oral administration of 2H may offer enhanced efficacy compared to intravenous delivery, emphasizing the importance of optimizing the AUC/MIC ratio for advancing its clinical therapy.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xerophilic Aspergillaceae Dominate the Communities of Culturable Fungi in the Mound Nests of the Western Thatching Ant (<i>Formica obscuripes</i>).","authors":"Rachelle M Gross, Courtney L Geer, Jillian D Perreaux, Amin Maharaj, Susan Du, James A Scott, Wendy A Untereiner","doi":"10.3390/jof10110735","DOIUrl":"10.3390/jof10110735","url":null,"abstract":"<p><p>The nests of mound-building ants are unexplored reservoirs of fungal diversity. A previous assessment of this diversity in the nests of <i>Formica ulkei</i> suggested that water availability may be a determinant of the composition of this mycota. To investigate this question, we recovered 3594 isolates of filamentous Ascomycota from the nests of <i>Formica obscuripes</i> and adjacent, non-nest sites, employing Dichloran Rose Bengal agar (DRBA), Dichloran Rose Bengal agar containing glycerol (DRBAG), and malt extract agar containing sucrose (MEA20S). Higher numbers of fungi were isolated from the tops of mounds than from within mounds and non-mound sites. Mound nest soils were dominated by members of the family Aspergillaceae, and up to 50% of the colonies isolated on DRBAG belonged to the genus <i>Aspergillus</i>. <i>Pseudogymnoascus pannorum</i> and species of <i>Talaromyces</i> were also present in higher numbers in mound soils. Species of <i>Penicillium</i> were more abundant in non-nest soils, where they accounted for over 66% of isolates on DRBA. All Aspergillaceae assessed for xerotolerance on a medium augmented with glycerol or sucrose were xerophilic. These results, and our observation that the nests of <i>F. obscuripes</i> are low-water environments, indicate that water availability influences the structure of the fungal communities in these animal-modified habitats.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Costs of Hospitalizations Due to Aspergillosis and 25-Year Trends in Spain, 1997-2021.","authors":"María Rincón Villar, Montserrat Alonso-Sardón, Elisa Alvarez-Artero, Beatriz Rodríguez Alonso, Amparo López-Bernús, Ángela Romero-Alegría, Javier Pardo-Lledías, Moncef Belhassen-García","doi":"10.3390/jof10110733","DOIUrl":"10.3390/jof10110733","url":null,"abstract":"<p><p>In the last 40 years, a significant increase in the incidence of lung infections by Aspergillus has been reported. The scarcity of studies that describe the costs of aspergillosis indicates that the economic impact of aspergillosis in the hospital environment is greater than that of other fungal infections. The objective of the study was to evaluate the direct healthcare costs associated with aspergillosis in the Spanish National Health System from 1997 to 2021. A retrospective nationwide longitudinal descriptive study was designed to review hospital records from the Minimum Basic Data Set of patients admitted to hospitals of the National Health System from 1997 to 2021, with a diagnosis of aspergillosis. A total of 44,586 patients were admitted for aspergillosis in the Spanish National Health System. There was a progressive increase in the average annual cost from 1997 to 2012, which reached a maximum peak, EUR 1,395,154.21 (±2,155,192.87). It decreased between 2014 and 2019, but increased again in 2020 and 2021, EUR 28,675.79 (±30,384.12). The Pearson correlation coefficient revealed a weak negative correlation between age and hospital costs and a moderate positive correlation between average length of stay and hospital costs. Our data show that the economic impact of hospitalizations for aspergillosis is significant and increasing at a rate proportionally higher than that of other prevalent diseases. Costs related to Aspergillus infection are associated mainly with respiratory diseases. The results of this economic evaluation may be useful for health authorities to develop a future economic strategy for managing this fungal infection.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of the Candidate Metabolite to Evaluate the Mycelium Physiological Maturation of <i>Lyophyllum decastes</i> Based on Metabolome and Transcriptome Analysis.","authors":"Lidan Liang, Xizhe Zang, Peijin Zhang, Jingwei Sun, Qingyun Shi, Siyuan Chang, Pengfei Ren, Zhuang Li, Li Meng","doi":"10.3390/jof10110734","DOIUrl":"10.3390/jof10110734","url":null,"abstract":"<p><p><i>Lyophyllum decastes</i> is a commercially cultivated rare edible mushroom with high dietary and medicinal value. The mycelium physiological maturation was an important factor to the yield and quality of mushrooms obtained. However, it was impossible to obtain discriminative characteristics represented the maturity level of the mycelia from morphological features. In this article, we screened a candidate metabolite for evaluating the mycelium physiological maturation by metabolomic and transcriptomic analysis during mycelial vegetative growth stages of <i>L. decastes</i>. The results showed that mycelial vegetative growth 55 d had reached to physiological maturation according to the yield and quality of <i>L. decastes</i>, which the single bottle yield (307 g/bottle), the contents of flavonoids (2.94 mg/g dry weight), and 5 flavor amino acids (glutamate 177.90 μg/g, aspartate 95.74 μg/g, phenylalanine 31.68 μg/g, tyrosine 13.79 μg/g, and alanine 10.99 μg/g) were the highest. In addition, the metabolomic and transcriptomic analysis results showed that biosynthesis of secondary metabolites and amino acid had significant different during mycelial vegetative growth stages, and glutamine may be a candidate indicator to evaluate the mycelial physiological maturation. These findings contribute to improve our knowledge of mycelium physiological maturation and it will be used to increase mushroom yield and quality.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11596021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Trichophyton indotineae Erg1</i>^Ala448Thr Strain Expressed Constitutively High Levels of Sterol 14-α Demethylase <i>Erg11B</i> mRNA, While Transporter <i>MDR3</i> and <i>Erg11A</i> mRNA Expression Was Induced After Addition of Short Chain Azoles.","authors":"Nadine Berstecher, Anke Burmester, Deborah Maria Gregersen, Jörg Tittelbach, Cornelia Wiegand","doi":"10.3390/jof10110731","DOIUrl":"10.3390/jof10110731","url":null,"abstract":"<p><p><i>Trichophyton indotineae</i> is an emerging pathogen causing recalcitrant skin infections and exhibiting multiple resistances to azoles and allylamines. Squalene epoxidase <i>erg1</i>^Ala448Thr mutants often show association with azole resistance. RT-PCR gene expression analysis helps to elucidate the connection between ergosterol biosynthesis regulation and efflux control through the activation of multidrug resistance (MDR) and major facilitator superfamily (MFS1) transporters as well as heat shock proteins (HSP). Several <i>T. indotineae</i> isolates demonstrated a heat-dependent increase of <i>Erg11B</i> transcripts combined with downregulation of <i>Erg1</i>, suggesting a protective role for <i>Erg11B</i>. They also showed persistent upregulation of <i>MFS1.</i> The addition of fluconazole or voriconazole induced the expression of <i>Erg11A</i>, <i>MDR3</i> and, to a lesser extent, <i>Erg11B</i> and <i>Erg1</i>. The azole-resistant <i>erg1</i>^Ala448Thr mutant UKJ 476/21 exhibited exceptionally high transcript levels of sterol 14-αdemethylase <i>Erg11B</i>, combined with the inability of HSP60 and HSP90 to respond to increasing growth temperatures. Itraconazole demonstrated similar effects in a few <i>T. indotineae</i> isolates, but terbinafine did not enhance <i>Erg1</i> transcription at all. Overexpression of <i>Erg11B</i> may explain the multiple azole resistance phenotype, whereas <i>Erg11B</i> point mutations are not associated with resistance to azoles used for medical treatment.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Yeast Isolated from the Gut Microbiota of Tunisian Children with Autism Spectrum Disorder.","authors":"Mariem Chamtouri, Abderrahmen Merghni, Katherine Miranda-Cadena, Nabil Sakly, Naoufel Gaddour, Clara G de Los Reyes-Gavilán, Maha Mastouri, Elena Eraso, Guillermo Quindós","doi":"10.3390/jof10110730","DOIUrl":"10.3390/jof10110730","url":null,"abstract":"<p><p>Research on the microbiota-gut-brain axis in autism has primarily focused on bacteria, with limited attention to fungi. There is a growing interest in understanding the involvement of fungi, particularly <i>Candida</i>, in patients with autism spectrum disorder. The aim of this study was to assess the prevalence, antifungal susceptibility profiles and virulence factors of <i>Candida</i> isolates from the guts of Tunisian children with autism. Twenty-eight children with autism and forty-six controls were enrolled. <i>Candida</i> isolates from the faecal samples were identified using biochemical and molecular methods; antifungal susceptibility testing was determined by the EUCAST broth microdilution method and virulence factors, including biofilm formation, cell surface hydrophobicity and phospholipase and proteinase activities, were assessed in vitro. As a result, <i>Candida</i> was detected in 13 children with autism (46.4%) and 14 control children (30.4%). <i>Candida albicans</i> was found to be the most common species isolate in the faeces of both groups of children. Antifungal susceptibility profiles showed that one <i>Candida</i> isolate was resistant to amphotericin B and anidulafungin (3.7%), six were resistant to micafungin (22.2%) and five were resistant to fluconazole (18.5%). All <i>Candida</i> isolates were biofilm producers. Of the twenty-seven isolates, only four showed phospholipase activity (14.8%), eight showed aspartyl-proteinase activity (29.6%) and nine were hydrophobic (33.3%). These results highlight the presence of <i>Candida</i> in the guts of children with autism, as well as the ability to express multiple virulence factors and the antifungal resistance, and they emphasize the need for further studies to confirm intestinal <i>Candida</i> colonization and its potential role in autism.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a High-Affinity Copper Transporter <i>CTR1a</i> in the White-Nose Syndrome Causing Fungal Pathogen <i>Pseudogymnoascus destructans</i>.","authors":"Saika Anne, Alyssa D Friudenberg, Ryan L Peterson","doi":"10.3390/jof10100729","DOIUrl":"10.3390/jof10100729","url":null,"abstract":"<p><p>Copper is an essential micronutrient and the ability to scavenge tightly bound or trace levels of copper ions at the host-pathogen interface is vital for fungal proliferation in animal hosts. Recent studies suggest that trace metal ion acquisition is critical for the establishment and propagation of <i>Pseudogymnoascus destructans</i>, the fungal pathogen responsible for white-nose syndrome (WNS), on their bat host. However, little is known about these metal acquisition pathways in <i>P. destructans.</i> In this study, we report the characterization of the <i>P. destructans</i> high-affinity copper transporter VC83_00191 (<i>Pd</i>CTR1a), which is implicated as a virulence factor associated with the WNS disease state. Using <i>Saccharomyces cerevisiae</i> as a recombinant expression host, we find that <i>Pd</i>CTR1a can efficiently traffic Cu ions into the yeast cytoplasm. Complementary studies in the native <i>P. destructans</i> fungus provide evidence that <i>Pd</i>CTR1a transcripts and protein levels are dictated by Cu-bioavailability in the growth media. Our study demonstrates that <i>Pd</i>CTR1a is a functional high-affinity copper transporter and is relevant to Cu homeostasis pathways in <i>P. destructans.</i></p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 10","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity and Antifungal Susceptibilities of Yeasts from Mangroves in Hong Kong, China-A One Health Aspect.","authors":"Pak-Ting Hau, Anson Shiu, Emily Wan-Ting Tam, Eddie Chung-Ting Chau, Michaela Murillo, Eva Humer, Wai-Wai Po, Ray Chun-Wai Yu, Joshua Fung, Sai-Wang Seto, Chi-Ching Tsang, Franklin Wang-Ngai Chow","doi":"10.3390/jof10100728","DOIUrl":"https://doi.org/10.3390/jof10100728","url":null,"abstract":"<p><p>While mangrove ecosystems are rich in biodiversity, they are increasingly impacted by climate change and urban pollutants. The current study provides first insights into the emergence of potentially pathogenic yeasts in Hong Kong's mangroves. Sediment and water samples were collected from ten urban and rural mangroves sites. Initial CHROMagar^TM Candida Plus screening, representing the first application of this differential medium for water and soil samples collected from a non-clinical environment, enabled the rapid, preliminary phenotypic identification of yeast isolates from mangroves. Subsequent molecular profiling (ITS and/or 28S nrDNA sequencing) and antifungal drug susceptibility tests were conducted to further elucidate yeast diversity and drug resistance. A diversity of yeasts, including 45 isolates of 18 distinct species across 13 genera/clades, was isolated from sediments and waters from Hong Kong mangroves. Molecular profiling revealed a dominance of the <i>Candida</i>/<i>Lodderomyces</i> clade (44.4%), a group of notorious opportunistic pathogens. The findings also reveal a rich biodiversity of non-<i>Candida</i>/<i>Lodderomyces</i> yeasts in mangroves, including the first reported presence of <i>Apiotrichum domesticum</i> and <i>Crinitomyces flavificans</i>. A potentially novel <i>Yamadazyma</i> species was also discovered. Remarkably, 14.3% of the ubiquitous <i>Candida parapsilosis</i> isolates displayed resistance to multiple antifungal drugs, suggesting that mangroves may be reservoirs of multi-drug resistance. Wildlife, especially migratory birds, may disseminate these hidden threats. With significant knowledge gaps regarding the environmental origins, drug resistance, and public health impacts of pathogenic yeasts, urgent surveillance is needed from a One Health perspective. This study provides an early warning that unrestrained urbanization can unleash resistant pathogens from coastal ecosystems globally. It underscores the necessity for enhanced surveillance studies and interdisciplinary collaboration between clinicians, ornithologists, and environmental microbiologists to effectively monitor and manage this environmental health risk, ensuring the maintenance of 'One Health'.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 10","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous Nitric Oxide Induces Pathogenicity of <i>Alternaria alternata</i> on Huangguan Pear Fruit by Regulating Reactive Oxygen Species Metabolism and Cell Wall Modification.","authors":"Di Wang, Haijue Zhang, Lingkui Meng, Xinyu Tan, Rong Liu, Qingchao Gao, Yan Wu, Yuhan Zhu, Xueyan Ren, Yongcai Li, Qingjun Kong","doi":"10.3390/jof10100726","DOIUrl":"https://doi.org/10.3390/jof10100726","url":null,"abstract":"<p><p>Black spot caused by <i>Alternaria alternata</i> is one of the most common postharvest diseases in fruit and vegetables. A comprehensive investigation into its pathogenicity mechanism is imperative in order to propose a targeted and effective control strategy. The effect of nitric oxide (NO) on the pathogenicity of <i>A. alternata</i> and its underlying mechanism was studied. The results showed that treatment with 0.5 mM L^-1 of sodium nitroprusside (SNP) (NO donor) increased the lesion diameter of <i>A. alternata</i> in vivo and in vitro, which was 22.8% and 13.2% higher than that of the control, respectively. Exogenous NO treatment also induced endogenous NO accumulation by activating nitric oxide synthase (NOS). In addition, NO triggered an increase in reactive oxygen species (ROS) levels. NO enhanced activities and gene expression levels of NADPH oxidase (NOX), superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX), and glutathione reductase (GR). Moreover, NO stimulated cell wall degrading enzymes by activating the corresponding gene expression in vivo and in vitro. These results suggested that exogenous NO promoted the pathogenicity of <i>A. alternata</i> by inducing ROS accumulation and activating antioxidants and cell wall degrading enzymes. The present results could establish a theoretical foundation for the targeted control of the black spot disease in pear fruit.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 10","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Diagnostic Approaches for Mucormycosis.","authors":"Jawad Safiia, Marco Aurelio Díaz, Hassan Alshaker, Christine J Atallah, Paul Sakr, Dimitrios G Moshovitis, Ahmad Nawlo, Andres E Franceschi, Alexis Liakos, Sophia Koo","doi":"10.3390/jof10100727","DOIUrl":"https://doi.org/10.3390/jof10100727","url":null,"abstract":"<p><p>Mucormycosis, an invasive fungal infection caused by members of the order Mucorales, often progresses fulminantly if not recognized in a timely manner. This comprehensive review discusses the latest developments in diagnostic approaches for mucormycosis, from traditional histopathology and culture-based methods to advanced and emerging techniques such as molecular assays, imaging, serology, and metabolomics. We discuss challenges in the diagnosis of mucormycosis and emphasize the importance of rapid and accurate identification of this life-threatening infection.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"10 10","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}