Journal of Fungi最新文献

{"title":"New Species of <i>Byssosphaeria</i> (Melanommataceae, Pleosporales) from the Mexican Tropical Montane Cloud Forest.","authors":"Aurora Cobos-Villagrán, Abigail Pérez-Valdespino, Ricardo Valenzuela, César Ramiro Martínez-González, Isolda Luna-Vega, Lourdes Villa-Tanaca, Aída Verónica Rodríguez-Tovar, Tania Raymundo","doi":"10.3390/jof11020089","DOIUrl":"10.3390/jof11020089","url":null,"abstract":"<p><p><i>Byssosphaeria</i> Cooke is a monophyletic genus of the family Melanommataceae. The genus is characterized by ascomata smaller than 1000 µm, globose, well-developed subiculum, with a flat ostiole, and yellow-orange or reddish-brown color around the ostiole. The peridium is composed of an external layer of irregular cells followed by an internal layer of thinner cells. Clavate asci have fusiform ascospores, a hyaline-to-brown color, with one or more septa. The genus <i>Byssosphaeria</i> is composed of 29 species: saprophytes, endophytes, and parasites of woody angiosperms, and they are found in wood, leaves, and other decaying substrates. The distribution of these species is cosmopolitan, and four species have been described in Mexico. This study describes, through morphological characteristics and the phylogenetic analysis of molecular markers (ITS, SSU, LSU, <i>tef1-α</i>), four new species of <i>Byssosphaeria</i>: <i>B. bautistae</i>, <i>B. chrysostoma</i>, <i>B. neorhodomphala</i>, and <i>B. neoschiedermayriana</i>. These species are saprophytes on wood rot and are distributed in mountainous mesophilic forests from the states of Hidalgo, Puebla, and Oaxaca. The significance of this study is in the diversity of this genus in Mexico since eight species have been described.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11857076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Moesziomyces aphidis</i> Bloodstream Infection in Oncologic Patient: First Report in Poland.","authors":"Beata Sulik-Tyszka, Jolanta Małyszko, Agnieszka Pęczuła, Sylwia Jarzynka","doi":"10.3390/jof11020095","DOIUrl":"10.3390/jof11020095","url":null,"abstract":"<p><p><i>Moesziomyces</i> spp. (<i>Pseudozyma</i>) is a genus recognized as a new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi's natural resistance to caspofungin enables them to spread through vascular catheter colonization, making them a new etiological agent associated with fungal bloodstream infections (FBIs) and a significant contributor to high mortality rates. In this report, we present a case of fungemia caused by <i>Moesziomyces aphidis</i> species in a patient with medical history that revealed pancreatic cancer infiltrating the duodenum and bile ducts. During hospitalization, the <i>M. aphidis</i> was cultured twice from peripheral blood samples on Sabouraud agar. The strain was sensitive to amphotericin B and voriconazole. In vitro susceptibility testing revealed resistance to fluconazole, caspofungin, anidulafungin, and micafungin. Antifungal therapy with voriconazole resulted in the resolution of clinical symptoms associated with fungal infection. Related to <i>M. aphidis</i> fungemia, we reviewed a total of three cases in Europe published in the PubMed database between 2003 and 2024. To the best of our knowledge, this is the first case of <i>M. aphidis</i> FBI in Poland and the fourth case in an adult patient in Europe.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Testing of Vaginal <i>Candida</i> Isolates in Pregnant Women: A Retrospective, Single-Center Study in Adana, Türkiye.","authors":"Mete Sucu, Nevzat Ünal, Ayşe Sultan Karakoyun, İrem Şahin, Oğuzhan Bingöl, Fatih Hüner, Fatma İşlek Uzay, İlker Ünal, Dilek Yeşim Metin, Macit Ilkit","doi":"10.3390/jof11020092","DOIUrl":"10.3390/jof11020092","url":null,"abstract":"<p><p>Clinical and mycological data are essential for the optimal management of patients with <i>Candida</i> vaginitis (CV), particularly in cases of (i) azole-resistant <i>C</i>. <i>albicans</i> vaginitis, (ii) recurrent CV, and (iii) CV in pregnant women. The present retrospective single-center study investigated the antifungal activity of six commonly used antifungals against randomly selected vaginal isolates recovered from 68 pregnant women in Adana, Türkiye, including <i>C</i>. <i>albicans</i>, petite <i>C</i>. <i>glabrata</i>, non-petite <i>C</i>. <i>glabrata</i>, and <i>C</i>. <i>krusei</i>, using the disk diffusion method at pH 4 and 7. Furthermore, the antifungal activities of fluconazole and itraconazole were also assessed using the broth microdilution method. For all isolates, the mean inhibition zone diameters were narrower for itraconazole and ketoconazole and larger for miconazole at pH 4 than pH 7 (<i>p</i> < 0.05). For nystatin, zone diameters were wider in <i>C</i>. <i>albicans</i> and petite <i>C</i>. <i>glabrata</i> at pH 4 (<i>p</i> < 0.001 and <i>p</i> < 0.001). Remarkably, clotrimazole was more active at pH 4 than at pH 7, except against non-petite <i>C</i>. <i>glabrata</i> isolates. Based on the broth microdilution results, the resistance rate was higher at pH 4 than at pH 7 in all isolates. <i>Candida glabrata</i> petite isolates exhibited MIC values 2 to 5 times higher than those of the non-petite isolates for both fluconazole and itraconazole. This study highlights the potent activity of topical antifungals (miconazole, nystatin, and clotrimazole) for the treatment of CV in pregnant women and highlights the need to identify petite and non-petite mutants of vaginal <i>C</i>. <i>glabrata</i> isolates to obtain more reliable data and for antifungal susceptibility testing prior to decision-making. The results of the two antifungal susceptibility methods were compared for <i>C. albicans</i> and <i>C. glabrata</i> isolates, and the reliability of the disk diffusion test was discussed.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics.","authors":"Vinicius Alves, Daniel Zamith-Miranda, Susana Frases, Joshua D Nosanchuk","doi":"10.3390/jof11020093","DOIUrl":"10.3390/jof11020093","url":null,"abstract":"<p><p>Metabolomics has emerged as a transformative tool in the study of microbes, including pathogenic fungi, facilitating the identification of unique metabolic profiles that elucidate their pathogenic mechanisms, host interactions, and treatment resistance. This review highlights key applications of metabolomics in understanding fungal metabolites essential for human virulence, such as mycotoxins produced by various fungal species, including <i>Aspergillus fumigatus</i> (gliotoxin, fumagillins) and <i>Candida</i> species (phenylethyl alcohol, TCA cycle metabolites), and secondary metabolites that contribute to pathogenicity. It also explores the metabolic adaptations of fungi in relation to drug resistance and biofilm formation, revealing alterations in key metabolic pathways during infection, as seen in <i>C. albicans</i> and <i>C. auris</i>. Furthermore, metabolomics aids in deciphering host-pathogen interactions, showcasing how fungi like <i>Cryptococcus neoformans</i> and <i>Candida</i> modify host metabolism to promote survival and evade immune responses. The study of antifungal resistance mechanisms has also benefited from metabolomic approaches, identifying specific metabolite patterns that signify resistance, such as in <i>Candida albicans</i> and <i>Candidozyma (Candida) auris</i>, and informing new therapeutic strategies. The integration of metabolomics with other omics technologies is paving the way for a comprehensive understanding of fungal biology and pathogenesis. Such multi-omics approaches are crucial for discovering new therapeutic targets and developing innovative antifungal treatments. Thus, the purpose of this review is to provide an overview of how metabolomics is revolutionizing our understanding of fungal pathogenesis, drug resistance, and host interactions, and to highlight its potential for identifying new therapeutic targets and improving antifungal strategies.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Fusarium musae</i> Infection in Animal and Plant Hosts Confirms Its Cross-Kingdom Pathogenicity.","authors":"Valeria Tava, Agustin Reséndiz-Sharpe, Eliane Vanhoffelen, Marco Saracchi, Paolo Cortesi, Katrien Lagrou, Greetje Vande Velde, Matias Pasquali","doi":"10.3390/jof11020090","DOIUrl":"10.3390/jof11020090","url":null,"abstract":"<p><p><i>Fusarium musae</i> is a pathogen belonging to the <i>Fusarium fujikuroi</i> species complex, isolated from both banana fruits and immunocompromised patients, therefore hypothesized to be a cross-kingdom pathogen. We aimed to characterize <i>F. musae</i> infection in plant and animal hosts to prove its cross-kingdom pathogenicity. Therefore, we developed two infection models, one in banana and one in <i>Galleria mellonella</i> larvae, as a human proxy for the investigation of cross-kingdom pathogenicity of <i>F. musae</i>, along with accurate disease indexes effective to differentiate infection degrees in animal and plant hosts. We tested a worldwide collection of <i>F. musae</i> strains isolated both from banana fruits and human patients, and we provided the first experimental proof of the ability of all strains of <i>F. musae</i> to cause significant disease in banana fruits, as well as in <i>G. mellonella</i>. Thereby, we confirmed that <i>F. musae</i> can be considered a cross-kingdom pathogen. We, thus, provide a solid basis and toolbox for the investigation of the host-pathogen interactions of <i>F. musae</i> with its hosts.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Genomes from Fungal the Entomopathogenic <i>Moelleriella</i> Genus Reveals Evolutionary History, Intron Dynamics and Phylogeny.","authors":"Chengjie Xiong, Yongsheng Lin, Nemat O Keyhani, Junya Shang, Yuchen Mao, Jiao Yang, Minghai Zheng, Lixia Yang, Huili Pu, Longbing Lin, Taichang Mu, Mengjia Zhu, Ziyi Wu, Zhenxing Qiu, Wen Xiong, Xiayu Guan, Junzhi Qiu","doi":"10.3390/jof11020094","DOIUrl":"10.3390/jof11020094","url":null,"abstract":"<p><p>Members of the genus <i>Moelleriella</i> (Hypocreales, Clavicipitaceae) are insect pathogens with specificity for scale insects and whiteflies. However, no mitochondrial genomes are available for these fungi. Here, we assembled seven mitogenomes from <i>M. zhongdongii</i>, <i>M. libera</i>, <i>M. raciborskii</i>, <i>M. gracilispora</i>, <i>M. oxystoma</i>, <i>Moelleriella</i> sp. CGMCC 3.18909, and <i>Moelleriella</i> sp. CGMCC 3.18913, which varied in size from 40.8 to 95.7 Kb. Synteny and codon usage bias was relatively conserved, with the mitochondrial gene arrangement being completely homologous to the gene order of 21 other species within the Hypocreales. Nevertheless, significant intron polymorphism was observed between <i>Moelleriella</i> species. Evolutionary analyses revealed that all 15 core protein-coding genes had ka/ks < 1, indicating purifying selection pressure. Sequence variation within the mitochondrial ATP synthase F0 subunit 6 (<i>atp6</i>) gene showed the largest genetic distance, with the ATP synthase F0 subunit 9 (<i>atp9</i>) gene showing the smallest. Comparative analyses of mitogenomes revealed that introns were the primary factor contributing to the size variation in <i>Moelleriella</i> and, more broadly, within Hypocreales mitogenomes. Phylogenetic analyses indicated that the seven <i>Moelleriella</i> species examined form a well-supported clade, most closely related to <i>Metarhizium</i>. These data present the first mitogenomes from <i>Moelleriella</i> and further advance research into the taxonomy, origin, evolution, and genomics of <i>Moelleriella</i>.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating the Value of (1,3)-β-D-Glucan for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients: Current Evidence and Future Directions.","authors":"Emmanuel Novy, Mathieu Esposito, Anne Debourgogne, Claire Roger","doi":"10.3390/jof11020091","DOIUrl":"10.3390/jof11020091","url":null,"abstract":"<p><p>Intra-abdominal candidiasis (IAC) is associated with significant diagnostic and therapeutic challenges in critically ill patients. Traditional fungal cultures are slow, delaying appropriate antifungal treatment. (1,3)-β-D-glucan (BDG), a component of the fungal cell wall, has emerged as a potential biomarker for IAC, but its use in ICU settings is complicated by frequent false-positives results from invasive procedures and underlying conditions. This review examines the diagnostic value of BDG when present in serum and peritoneal fluid. While serum BDG is effective for excluding invasive fungal infections like candidemia, its specificity for IAC remains low in critically ill patients. Recent studies suggest that BDG levels in peritoneal fluid may provide better diagnostic accuracy, distinguishing IAC from bacterial peritonitis with higher specificity. We discuss the advantages, limitations, and practical aspects of BDG testing, emphasizing the potential of peritoneal BDG as a complementary tool. Further research is needed to refine diagnostic thresholds, validate its clinical utility, and establish the role of peritoneal BDG in improving timely, targeted antifungal treatment for IAC.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species Diversity of <i>Gymnopus</i> Section <i>Levipedes</i> in Southwestern China, with a Description of Three New Species.","authors":"Wei-Chao Feng, Xiao-Yan Li, Yang-Yang Cui, Qing Cai","doi":"10.3390/jof11020088","DOIUrl":"10.3390/jof11020088","url":null,"abstract":"<p><p>Species of <i>Gymnopus</i> sect. <i>Levipedes</i> are challenging to delimitate due to the morphological similarity among different taxa. In this study, morphological characteristics, molecular phylogenetic data, and ecological traits were integrated to investigate the species diversity of this section of southwestern China. A total of 17 species were documented in the region, including three new species, namely <i>G</i>. <i>sinobrevipes</i>, <i>G. flavoalbus</i>, <i>G</i>. <i>yunnanensis</i>, and two species new to the studied area-<i>G. bicolor</i> and <i>G. ocior.</i> Detailed descriptions and illustrations of the three new species are presented, along with comparisons to closely related or morphologically similar species. The remaining species included five that were originally described from southwestern China, four that were first identified from Europe, two from the Republic of Korea, and one from North America. Six of these species, originally described outside of China, currently lack molecular evidence to support their distributions in southwestern China. Finally, 11 species with morphological and molecular evidence were recognized in southwestern China. A key to these species is also provided.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture-Dependent and -Independent Wastewater Surveillance for Multiple Pathogenic Yeasts.","authors":"Tyla Baker, Phillip Armand Bester, Olihile Moses Sebolai, Jacobus Albertyn, Carolina Henritta Pohl","doi":"10.3390/jof11020086","DOIUrl":"10.3390/jof11020086","url":null,"abstract":"<p><p>Wastewater surveillance is a promising tool to monitor potential outbreaks and determine the disease burden within a community. This system has been extensively used to monitor polio and COVID-19 infection levels, yet few attempts have been made to apply it to monitoring pathogenic yeast. This study aimed to investigate the application of wastewater surveillance for potentially pathogenic yeast in wastewater treatment plant influent. This was done by comparing culture-dependent data with culture-independent data and investigating the fluconazole concentration in wastewater. Additional studies on the growth of isolated strains were conducted. We found that a multiplex PCR system to detect multiple yeasts holds promise as a molecular detection tool for wastewater surveillance. Culture-dependent results indicated that <i>Candida</i> spp. specifically <i>C. krusei</i> and <i>C. glabrata</i>, were most prominent. Growth studies supported that these species grow well in this environment while the less frequently isolated yeasts grew poorly. The data from culture-dependent and independent techniques showed some correlation, with similar species being identified with both, further promoting the use of molecular tools for surveillance. This study highlights the presence of potentially pathogenic yeasts in wastewater, which may indicate the prevalence of these yeasts in the environment or community. This wastewater may also be a potential source of infection for persons encountering it due to poor wastewater management.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan.","authors":"Anas H Abu-Humaidan, Areen Alshdaifat, Dima Awajan, Mohammad Abu-Hmidan, Abeer Alshdifat, Hanan Hasan, Fatima M Ahmad, Nader Alaridah, Amal Irshaid, Dina Yamin","doi":"10.3390/jof11020087","DOIUrl":"10.3390/jof11020087","url":null,"abstract":"<p><p><i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teaching hospital's microbiology lab (from 2017 to 2022). Complete records of <i>Candida</i> isolates (n = 2673) were assessed by sample type, species, and AMR. Among positive blood samples, <i>C. albicans</i> accounted for the majority (38.7%), followed by <i>C. tropicalis</i> (19.0%), <i>C. parapsilosis</i> (18.3%), <i>Nakaseomyces glabratus</i> (14.6%), and <i>Pichia kudriavzevii</i> (9.5%). Non-<i>albicans</i> species demonstrated higher resistance to Caspofungin, notably <i>P. kudriavzevii</i> (23.1%), <i>N. glabratus</i> (30.0%), and <i>C. parapsilosis</i> (32.0%), compared to <i>C. albicans</i> (1.9%). In high vaginal swabs, <i>C. albicans</i> was most prevalent (63.7%), with <i>N. glabratus</i> also notable (28.6%); Fluconazole resistance in <i>C. albicans</i> remained low (2.0%). Across all pooled isolates, AMR was similar between inpatients and outpatients, except for Micafungin, where inpatient resistance was significantly higher. In conclusion, non-<i>albicans</i> species predominated in blood infections and demonstrated pronounced AMR. Micafungin resistance was notably higher among inpatients. Variations in <i>Candida</i> species and AMR by sample type suggest that aggregating samples in registry studies may obscure critical patterns.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11857050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}