Journal of Fungi最新文献

{"title":"Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection.","authors":"Alexander M Aldejohann, Antonio Uribe Munoz, Miriam A Füller, Grit Walther, Oliver Kurzai, Frieder Schaumburg, Ronald Sträter, Jenny Potratz, Julia Sandkötter, Daniel Ebrahimi-Fakhari, Christian P Stracke, Laura Beck, Christian Thomas, Andreas H Groll","doi":"10.3390/jof11090618","DOIUrl":"10.3390/jof11090618","url":null,"abstract":"<p><p>Mucormycosis is a rare invasive fungal disease in pediatric patients with hematological malignancies and is associated with poor outcomes. We present a fulminant and ultimately fatal case of rhino-orbito-cerebral mucormycosis, addressing important issues including clinical signs and symptoms, diagnostic approaches and the challenges of timely diagnosis. The patient was an 11-year old girl undergoing re-induction chemotherapy for Central Nervous System relapse of B-cell precursor acute lymphoblastic leukemia. She presented six days into the second course of chemotherapy in profound neutropenia with aggravating headaches, painful abducens nerve palsy and anisocoria. At first (day -3), no significant radiological or ophthalmological correlations were found, and methyl-prednisolone was started due to suspected vasculitis following ICU admission. After further clinical deterioration, a second MRI scan (day 0) revealed a prolonged occlusion of the left carotid artery, which was successfully stented in a neuroradiological intervention (day +1). However, during the next day the child developed clinical signs indicating severe cerebral dysfunction. An emergency CT scan showed complete infarction of the left hemisphere including a progredient perfusion deficit and beginning brain edema. Based on the unfavorable prognosis, best supportive care was initiated, and the patient deceased on day +2. Pathological and microbiological workup identified thrombotic infarction in all major cerebral arteries. While microscopy was suspicious for mucormycosis, nested PCR from retained blood specimens confirmed the genus <i>Lichtheimia</i>. Final NGS on brain tissue led to the identification of <i>Lichtheimia ramosa.</i> This case illustrates the rapidity and severity of Mucorales infection. It shows the importance of early clinical suspicion and the need for an aggressive laboratory testing algorithms. The stratification of risk factors and definition of red flags may be a future task fighting these infections.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arbuscular Mycorrhizal Fungi Promote Soil Respiration Primarily Through Mediating Microbial and Root Biomass in Rocky Desertification Habitat.","authors":"Shuang Zhao, Shaojun Wang, Yali Song, Lingling Xie, Bo Xiao, Xiaofei Guo","doi":"10.3390/jof11090616","DOIUrl":"10.3390/jof11090616","url":null,"abstract":"<p><p>Arbuscular mycorrhizal (AM) fungi can have complicated interactions with plants and soils, which play a critical role in mediating the soil carbon cycle. However, the mechanism by which AM fungi regulate soil respiration is not well documented. This study conducted a completely randomized block-design mesocosm experiment using the inoculation of AM fungi (RI: <i>Rhizophagus intraradices</i>; FM: <i>Funneliformis mosseae</i>) with <i>Fraxinus malacophylla</i> to identify the pathways of AM fungi controlling soil respiration in a rocky desertification habitat. We observed that the average soil respiration rates (3.78 μmol·m^-2·s^-1) were significantly higher in two AM fungi inoculation treatments than in the control (2.87 μmol·m^-2·s^-1). Soil respiration rates were 1.59-fold higher in RI fungi inoculation and 1.05-fold higher in FM inoculation than in the control. Explanation rates of microbial biomass carbon, biomass nitrogen, and root biomass in RI (57.46-76.49%) and FM (44.81-62.62%) inoculation for soil respiration variation were higher than those in the control (24.51-34.32%). The direct positive pathway of soil respiration was mainly regulated by microbial biomass (59.5%) and root biomass (34.90%), while the indirect positive contributions of soil physicochemical properties (30.00%), colonization level (3.50%), soil microclimate (19.30%), and enzyme activity (3.38%) to respiration dynamics ranked second. Thus, we conclude that soil respiration dynamics can be mainly controlled by AM fungi-mediated changes in microbial and root biomass in rocky desertification areas.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Aspergillosis in Immunocompromised Critically Ill Patients: Prevalence, Risk Factors, Clinical Features and Diagnosis-A Narrative Review.","authors":"Maria Grazia Bocci, Laura Cascarano, Giulia Capecchi, Antonio Lesci, Valerio Sabatini, Dorotea Rubino, Giulia Valeria Stazi, Gabriele Garotto, Stefania Carrara, Antonella Vulcano, Chiara Gori, Franca Del Nonno, Daniele Colombo, Laura Falasca, Emanuela Caraffa, Stefania Cicalini, Carla Fontana","doi":"10.3390/jof11090617","DOIUrl":"10.3390/jof11090617","url":null,"abstract":"<p><p>Aspergillosis in immunocompromised individuals is a serious and potentially life-threatening infection, as the weakened immune system cannot effectively fight the <i>Aspergillus</i> fungus. This review provides an in-depth examination of aspergillosis in patients with various conditions that compromise immunity, including hematological disorders, HIV, SARS-CoV-2 pneumonia, influenza, and those who have undergone solid organ transplants. The clinical manifestations of aspergillosis are influenced by factors such as the host's underlying comorbidities, immune response, and immune suppression due to medications or treatments. The review delves into the epidemiology of aspergillosis, exploring various risk factors that predispose individuals to infection. It also discusses the wide range of clinical symptoms, highlighting the challenges in diagnosis and the importance of early detection. The review contrasts traditional diagnostic approaches with emerging molecular techniques, emphasizing the role of advanced diagnostics in improving outcomes. A proposed clinical decision-making flowchart is provided to assist healthcare professionals in managing suspected cases of aspergillosis. In addition to diagnostic challenges, the review addresses antifungal prophylaxis, pre-emptive therapy, and the growing concern of pharmacological resistance to antifungal agents. It concludes with a discussion of future research directions, underscoring the need for improved therapeutic strategies and preventative measures in immunocompromised patients to reduce the burden of this severe fungal infection.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Propylphenol Alters Membrane Integrity in Fungi Isolated from Walnut Anthracnose and Brown Spot.","authors":"Xiaoli Yu, Shuhan Yang, Panhong Su, Haiyao Bi, Yaxuan Li, Xingxing Peng, Xiaohui Sun, Qunqing Wang","doi":"10.3390/jof11090610","DOIUrl":"10.3390/jof11090610","url":null,"abstract":"<p><p>Walnut anthracnose (<i>Colletotrichum gloeosporioides</i> and <i>C. siamense</i>) and brown spot (<i>Alternaria alternata</i>) cause severe yield losses globally. Conventional fungicides face the challenges of pathogen resistance and environmental toxicity. This study evaluates 4-propylphenol, a plant-derived phenolic compound, as an eco-friendly alternative against key fungal pathogens of walnut. In vitro assays determined EC₅₀ values against target pathogens (29.11-31.89 mg·L^-1) via mycelial growth inhibition and conidial germination suppression (EC₅₀ = 55.04-71.85 mg·L^-1). Mechanistic analyses confirmed membrane disruption through propidium iodide staining (9.5-to-14.0-fold fluorescence intensity increase), DNA leakage (77.82-85.15% at 250 mg·L^-1), and protein efflux (58.10-66.49%). In field trials, we implemented a phenology-driven strategy: 100 mg·L^-1 ground/canopy spray at flowering to reduce primary inoculum, followed by 400 mg·L^-1 canopy application at fruiting. This protocol achieved 86.67% control efficacy against disease complexes with negligible phytotoxicity (SPAD variation < 5%). 4-propylphenol provides a sustainable solution through membrane-targeting action, effectively overcoming fungicide resistance in woody crops.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Cuminate Inhibits the Mycelial Growth of <i>Penicillium digitatum</i> by Inducing Oxidative Stress and Damaging the Cell Membrane.","authors":"Mingchen Yang, Yonghua Zhang, Xiaoli Tan, Lu Li, Qiuli OuYang, Nengguo Tao","doi":"10.3390/jof11090612","DOIUrl":"10.3390/jof11090612","url":null,"abstract":"<p><p>Green mold formed by <i>Penicillium digitatum</i> is a major disease that limits the yield and overall value of postharvest citrus fruits. The antifungal activity of sodium cuminate (SC) against <i>P. digitatum</i> and the corresponding mechanism were explored in this research. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of SC against <i>P. digitatum</i> were 0.4 and 0.8 g L^-1, respectively. SC (8× MFC) reduced the incidence of disease in Ponkan fruits without compromising their quality. The results of CFW staining and extracellular alkaline phosphatase assays revealed that 1/2MIC SC for 30 min had no impact on the cell wall integrity of <i>P. digitatum</i>. In contrast, 1/2MIC SC apparently destroyed cell membrane integrity, as shown by the increase in the content of reactive oxygen species (ROS), malondialdehyde, and H₂O₂. The addition of exogenous cysteine (Cys) or diphenyleneiodonium chloride (DPI) significantly mitigated the cytotoxic effects of SC. At the same time, mitochondrial membrane potential was significantly decreased by 1/2MIC SC, and the addition of exogenous Cys or DPI restored it to normal levels. In summary, the antifungal capacity of SC might be attributable to membrane damage in <i>P. digitatum</i> caused by oxidative stress.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of <i>Macadamia integrifolia</i> Leaf Blight Disease Caused by <i>Pestalotiopsis colombiensis</i> in China.","authors":"Huizhi Yu, Youyan Lei, Ling Ma, Xiahong He, Wenhao Dai, Jie Chen, Xin Hao","doi":"10.3390/jof11090613","DOIUrl":"10.3390/jof11090613","url":null,"abstract":"<p><p><i>Macadamia integrifolia</i>, a tropical and subtropical fruit tree with significant economic and nutritional value, faces serious fungal disease problems during cultivation that severely affect yield and quality. In November 2024, leaf blight symptoms of <i>M. integrifolia</i> were observed in Menglian, Pu'er, Yunnan, China, with a disease incidence of 23% in the field. Initial symptoms included small spots that enlarged into circular to irregular lesions with red-brown centers and brown to black margins. Finally, the leaves turned yellow and became scorched, eventually leading to massive leaf shedding. Infected leaf samples were collected, and fungal strains were isolated, purified, and inoculated via spore suspension, followed by re-isolation. The strains were conclusively identified as <i>Pestalotiopsis colombiensis</i> (SWFUCB2, SWFUCB1) through an integrated approach combining DNA extraction, polymerase chain reaction (PCR), sequencing, phylogenetic reconstruction, and morphological characterization. This is the first report of <i>P. colombiensis</i> causing <i>M. integrifolia</i> leaf blight disease in China, filling a gap in research on this disease. This study provided important information for epidemiological research on this disease and the development of comprehensive leaf blight disease control strategies.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidification and Nutrient Imbalances Drive Fusarium Wilt Severity in Banana (<i>Musa</i> spp.) Grown on Tropical Latosols.","authors":"Tao Jing, Kai Li, Lixia Wang, Mamdouh A Eissa, Bingyu Cai, Tianyan Yun, Yingdui He, Ahmed A El Baroudy, Zheli Ding, Yongzan Wei, Yufeng Chen, Wei Wang, Dengbo Zhou, Xiaoping Zang, Jianghui Xie","doi":"10.3390/jof11090611","DOIUrl":"10.3390/jof11090611","url":null,"abstract":"<p><p>Fusarium wilt, caused by <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> (FOC), remains a major constraint to global banana (<i>Musa</i> spp.) production, especially in tropical regions. Although soil conditions are known to modulate disease expression, the specific physicochemical drivers of FOC prevalence under field conditions are not well understood. This study investigated the relationships between soil properties and the Fusarium wilt incidence across 47 banana farms on Hainan Island, China, a tropical region dominated by highly weathered tropical soil (latosols). The disease incidence (%PDI) and FOC abundance were quantified, alongside key soil parameters, including the pH, organic carbon, cation exchange capacity, and macro- and micronutrient availability. The soils were predominantly acidic (mean pH 4.93), with low levels of organic carbon and exchangeable calcium (Ca) and elevated levels of available phosphorus (P), potassium (K), and magnesium (Mg). The Fusarium wilt incidence ranged from 1% to 78%, with significantly higher levels observed in younger plantations (<5 years old). Statistical analyses revealed strong negative correlations between the PDI and the soil pH, exchangeable Ca and Mg, and available K. Principal component analysis further confirmed the suppressive role of the pH and base cations in the disease dynamics. Farms older than five years exhibited better soil fertility indices and lower disease pressure, suggesting a temporal improvement in soil-mediated disease suppression. These findings underscore the critical role of soil acidification and nutrient imbalances, particularly Ca, Mg, and K deficiencies, in promoting FOC pathogenicity. Enhancing soil health offers a promising and sustainable strategy for managing Fusarium wilt in tropical banana production systems.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Climate, Changing <i>Candida</i>: Environmental and Social Pressures on Invasive Candidiasis and Antifungal Resistance in Latin America.","authors":"Juan Camilo Motta, Pilar Rivas-Pinedo, José Millan Onate","doi":"10.3390/jof11090609","DOIUrl":"10.3390/jof11090609","url":null,"abstract":"<p><p>Invasive candidiasis (IC) in Latin America is undergoing a significant epidemiological shift, increasingly driven by non-<i>albicans</i> strains such as <i>Candida tropicalis</i>, <i>Candida parapsilosis</i>, and <i>Candidozyma auris</i>. These pathogens often exhibit multidrug resistance, which complicates treatment and increases mortality. Diagnostic limitations, particularly in rural and public hospitals, delay detection and hinder the provision of rapid care. Environmental pressures, such as climate change and the widespread use of azoles in agriculture, appear to favor the selection of resistant and thermotolerant strains. Migratory birds may also play a role in the environmental transmission of pathogenic fungi. These factors are amplified by socioeconomic inequalities that restrict access to diagnostics and first-line antifungals. To help mitigate this emerging challenge, a One Health-oriented framework combining integrated environmental surveillance, robust antifungal-stewardship programmers, broader diagnostic access, and coordinated cross-sector public health actions should be developed. Reinforcing these pillars could lessen the regional burden of IC and slow the advance of antifungal resistance.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community Structure Diversity of Endophytic Fungi in <i>Cissampelos pareira</i> from Different Habitats and Their α-Glucosidase Inhibitory Activity.","authors":"Jing Yu, Cuiyun Yin, Zhaoyou Deng, Yin Yuan, Deying Tang, Xuanchao Shi, Yihang Li, Lixia Zhang","doi":"10.3390/jof11090615","DOIUrl":"10.3390/jof11090615","url":null,"abstract":"<p><p><i>Cissampelos pareira</i> is a medicinal plant with the potential effect of treating diabetes, commonly used by the Dai people in southern Yunnan Province. However, the wild resources of <i>C. pareira</i> are currently scarce. Endophytic fungi are a natural component of medicinal plants, while also serving as important repositories for discovering active natural products. In this study, we focused on 2-year-old <i>C. pareira</i> plants cultivated in potted and non-potted conditions. The community structure of endophytic fungi in the roots, stems, leaves, and flowers of two cultivation methods of <i>C. pareira</i> was investigated by using high-throughput sequencing (HTS) and traditional culture methods. Through HTS, we discover that the richness and diversity of endophytic fungi in <i>C. pareira</i> are associated with its growth environment and plant tissues. The endophytic fungi richness of <i>C. pareira</i> showed significant differences between the two habitats. And significant differences existed in the diversity of root endophytic fungi of <i>C. pareira</i> compared to those in the stems, leaves, and flowers. Additionally, the richness of endophytic fungi in the stems showed significant differences from that in the roots, leaves, and flowers. The results obtained using traditional culture methods revealed 69 endophytic fungi strains, classified into 2 phylum, 4 classes, 11 orders, 23 families, and 69 genera. The fermentation products of the obtained strains were evaluated for in vitro α-glucosidase inhibitory activity, and the results demonstrated that 11 endophytic fungi strains exhibited an inhibition rate exceeding 80%. The above-mentioned study can provide a theoretical basis for a comprehensive understanding of the community composition and diversity of endophytic fungi in <i>C. pareira</i>.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome Sequencing and Comparative Genomics of the Hyper-Cellulolytic Fungus <i>Talaromyces pinophilus</i> Y117.","authors":"Ya Li, Siyuan Yue, Peng Li, Jing Zeng, Jianjun Guo, Dawei Xiong, Shuaiwen Zhang, Tao Deng, Lin Yuan","doi":"10.3390/jof11090614","DOIUrl":"10.3390/jof11090614","url":null,"abstract":"<p><p><i>Talaromyces pinophilus</i> is a filamentous fungus with notable lignocellulose-degrading capacity based on enzyme activities and protein secretion potential, making it a compelling candidate for industrial biotechnology applications. In this study, we present the genomic characterization of the highly cellulolytic strain Y117, a domesticated variant of <i>T. pinophilus</i>, based on whole-genome sequencing and comparative genomic analysis with eleven related strains. Comprehensive analysis of CAZymes, transcription factors, and secondary metabolite diversity in <i>T. pinophilus</i> strains revealed that the exceptional lignocellulose degradation capacity of Y117 is driven by its unique genomic architecture. Key genomic features that distinguish Y117 include (1) significant expansion of glycoside hydrolase (GH) and carbohydrate-binding module (CBM) families, (2) loss of fungal-RiPP-like clusters, and (3) absence of the developmental regulator BrlA. These genomic adaptations could indicate a metabolic trade-off favoring hydrolytic enzyme production over secondary metabolism and sporulation. Our findings provide fundamental insights into fungal lignocellulose degradation mechanisms while establishing Y117 as a promising chassis for metabolic engineering applications in industrial enzyme production and heterologous protein expression.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}