Journal of Fungi最新文献

Species Distribution and Antifungal Susceptibility Patterns of Invasive Candidiasis in a Belgian Tertiary Center: A 7-Year Retrospective Analysis. 比利时三级中心侵袭性念珠菌病的物种分布和抗真菌药敏模式：7年回顾性分析。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-19 DOI: 10.3390/jof11060465

Sarah Cugnata, Rosalie Sacheli, Nathalie Layios, Marie-Pierre Hayette

{"title":"Species Distribution and Antifungal Susceptibility Patterns of Invasive Candidiasis in a Belgian Tertiary Center: A 7-Year Retrospective Analysis.","authors":"Sarah Cugnata, Rosalie Sacheli, Nathalie Layios, Marie-Pierre Hayette","doi":"10.3390/jof11060465","DOIUrl":"10.3390/jof11060465","url":null,"abstract":"Candidiasis is a major fungal infection worldwide, with invasive forms linked to high morbidity and mortality. The emergence of azole resistance in Candida parapsilosis causing candidemia led us to examine the epidemiology and antifungal susceptibility of Candida species at the University Hospital of Liège between January 2017 and December 2023. A total of 916 isolates from blood or sterile body fluids, tissues, and abscesses were analyzed. Species identification was performed using MALDI-TOF MS and antifungal susceptibility testing via Sensititre YO10 AST was interpreted according to the CLSI guidelines. Candida albicans remained the predominant species (56%), followed by Nakaseomyces glabratus (19%), Candida parapsilosis (8%), and Candida tropicalis (7%). No significant shift toward non-albicans Candida species (NAC) was observed even during the COVID-19 pandemic, supporting the use of narrow-spectrum empirical therapy in selected patients. Fluconazole susceptibility was high in C. albicans (98.8%), whereas N. glabratus and C. tropicalis showed high resistance rates with 10.1% and 16.9%, respectively. C. parapsilosis showed stable fluconazole susceptibility across the study period. Echinocandins demonstrated excellent activity (95.6-100%), and amphotericin B was effective against nearly all isolates. This seven-year surveillance at the University Hospital of Liège confirms that while C. albicans remains the predominant and highly susceptible species, rising azole resistance in non-albicans Candida-particularly N. glabratus and C. tropicalis-highlights the critical need for ongoing local epidemiological monitoring to guide effective and targeted antifungal therapy.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histoplasmosis in Immunocompromised and Immunocompetent Patients in Guadeloupe. 瓜德罗普岛免疫功能低下和免疫功能正常患者的组织浆菌病。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-18 DOI: 10.3390/jof11060462

Constance Lahuna, Tanguy Dequidt, Pierre Postel-Vinay, Sandrine Peugny, Marwan Haboub, Samuel Markowicz, Muriel Nicolas

{"title":"Histoplasmosis in Immunocompromised and Immunocompetent Patients in Guadeloupe.","authors":"Constance Lahuna, Tanguy Dequidt, Pierre Postel-Vinay, Sandrine Peugny, Marwan Haboub, Samuel Markowicz, Muriel Nicolas","doi":"10.3390/jof11060462","DOIUrl":"10.3390/jof11060462","url":null,"abstract":"Background:Histoplasma capsulatum is an environmentally acquired dimorphic fungus. Infection results in histoplasmosis, a clinical syndrome often underdiagnosed and that may progress to life-threatening disseminated infection not only in immunocompromised individuals but also, following high-level exposure, in immunocompetent hosts. Epidemiological data from Caribbean regions, and particularly from Guadeloupe, remain limited. Methods: We performed a retrospective cohort study of all microbiologically confirmed histoplasmosis cases managed at the University Hospital of Guadeloupe between January 2014 and October 2024. Demographic, clinical, diagnostic, therapeutic, and outcome data were retrieved from medical records and analyzed using descriptive statistics. Results: Forty-two patients met the inclusion criteria, corresponding to an estimated annual incidence rate of 1 per 100,000 inhabitants. The median age was 52 years, and the male-to-female ratio was 4:1. An underlying immunocompromising condition was present in 85% of cases, most commonly HIV infection (48%). Common clinical features included weight loss (97%), fever (89%), and pulmonary manifestations (81%). The mean time to diagnosis from hospital admission was 3.5 ± 10.3 days. Direct microscopy was positive in 67% of cases, and culture was positive in 88% of cases. Intravenous liposomal amphotericin B constituted the initial therapy in 71% of patients. Overall, the in-hospital mortality was 29%, rising to 40% among HIV-positive individuals. The 30-day survival rate was 71%. Conclusions: Histoplasmosis in Guadeloupe is under-recognized and associated with appreciable morbidity and mortality in both immunocompromised and immunocompetent patients. The wider availability of rapid diagnostics and heightened clinical vigilance are essential to shorten diagnostic delays and improve outcomes in this Caribbean population.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Therapeutic Options for Fusariosis: A Patent Review (2008-2023). 镰孢病的新治疗选择：专利审查（2008-2023）。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-18 DOI: 10.3390/jof11060463

Izadora Dillis Faccin, Túlio Máximo Salomé, Gleyce Hellen de Almeida de Souza, Leonardo da Costa Xavier, Izabel Almeida Alves, Vanessa Castro Felix Lima, Fabíola Lucini, Simone Simionatto, Luana Rossato

{"title":"New Therapeutic Options for Fusariosis: A Patent Review (2008-2023).","authors":"Izadora Dillis Faccin, Túlio Máximo Salomé, Gleyce Hellen de Almeida de Souza, Leonardo da Costa Xavier, Izabel Almeida Alves, Vanessa Castro Felix Lima, Fabíola Lucini, Simone Simionatto, Luana Rossato","doi":"10.3390/jof11060463","DOIUrl":"10.3390/jof11060463","url":null,"abstract":"Fusariosis is an infection caused by the fungus Fusarium spp., which is pathogenic to both plants and humans. The disease presents several clinical manifestations and epidemiological patterns. Current treatment relies on azoles and polyenes, but increasing antifungal resistance requires the exploration of new therapeutic options. This study reviewed patents related to the treatment of Fusariosis from the last 15 years (up to June 2023). The search identified 318 patents, categorized by identification code, publication date, type of application and mechanism of action, using the International Patent Classification and Cooperative Patent Classification systems. In addition, we conducted a bibliographic search in the PubMed database using the same criteria to identify the number of scientific articles. Of the 318 patents, 21 targeted Fusarium infections in humans. The years 2014 and 2018 stood out with three patents each, while the same period recorded an average of 58 published articles. The patents addressed mechanisms such as drug delivery, gene expression, immunotherapy, engineered drugs, and novel compounds. This research highlights the urgent need for continued innovation in therapeutic technologies to effectively treat Fusarium wilt.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress. 蛹虫草CH1基因组的端粒-端粒组装及转录组学和代谢组学分析为光胁迫下虫草素的生物合成提供了新的见解。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-18 DOI: 10.3390/jof11060461

Yang Yang, Jingjing Huang, Gangqiang Dong, Xuebo Hu

{"title":"Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress.","authors":"Yang Yang, Jingjing Huang, Gangqiang Dong, Xuebo Hu","doi":"10.3390/jof11060461","DOIUrl":"10.3390/jof11060461","url":null,"abstract":"Cordyceps militaris, a model species in the genus Cordyceps, is widely distributed globally and is known for its significant medicinal value. It has been traditionally used in Chinese medicine to enhance immunity, alleviate fatigue, and treat tumors, among other therapeutic purposes. Here, we successfully assembled a telomere-to-telomere (T2T) level genome of C. militaris CH1 using PacBio HiFi and Hi-C technologies. The assembled genome is 32.67 Mb in size, with an N50 of 4.70 Mb. Gene prediction revealed a total of 10,749 predicted genes in the C. militaris CH1 genome, with a gene completeness of 99.20%. Phylogenetic analysis showed the evolutionary relationship between C. militaris CH1 and other Cordyceps species, suggesting that the divergence between this strain and C. militaris ATCC 34164 occurred approximately 1.36 Mya. Combined transcriptomic and metabolomic analyses identified 842 differentially expressed genes and 2052 metabolites that were significantly altered under light stress, primarily involving key pathways related to amino acid metabolism, purine metabolism, and secondary metabolite biosynthesis. Joint analysis of genes and metabolites revealed 79 genes coding for enzymes associated with the synthesis of adenine and adenosine, with the expression of 52 genes being upregulated, consistent with the accumulation trends of adenine and adenosine. Four gene clusters related to the synthesis of cordycepin were identified, with a significant upregulation of cns3 (FUN_003263), suggesting that light stress may promote cordycepin biosynthesis. This comprehensive analysis not only provides new insights into the genomics, metabolomics, and functional gene research of C. militaris CH1 but also offers a potential biological foundation for understanding the synthesis mechanisms of cordycepin and its efficient production.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Entomopathogenic Fungi Activity from the Fiocruz Amazônia Collection in Anopheles aquasalis Mosquitoes. 水按蚊Fiocruz Amazônia昆虫病原真菌活性评价。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-18 DOI: 10.3390/jof11060464

Natalia Stefany Pereira, Camila Fabbri, Kemily Nunes Moya, Ana Carolina Monteiro Ferreira, Francy's Sayara Andrade, Rosa Amélia Santana, Claudia Maria Ríos-Velásquez, Priscila Ferreira de Aquino, Stefanie Costa Pinto Lopes

{"title":"Assessment of Entomopathogenic Fungi Activity from the Fiocruz Amazônia Collection in Anopheles aquasalis Mosquitoes.","authors":"Natalia Stefany Pereira, Camila Fabbri, Kemily Nunes Moya, Ana Carolina Monteiro Ferreira, Francy's Sayara Andrade, Rosa Amélia Santana, Claudia Maria Ríos-Velásquez, Priscila Ferreira de Aquino, Stefanie Costa Pinto Lopes","doi":"10.3390/jof11060464","DOIUrl":"10.3390/jof11060464","url":null,"abstract":"Malaria remains a public health issue across the world. Different methods have been analyzed to achieve this disease's elimination, such as the vector control of Anopheles spp. Control strategies include the use of different classes of insecticides, although the accelerated evolution of vectors resistant to them makes the development of alternative control methods necessary. Therefore, entomopathogenic fungi have been considered to be promising biopesticides, given that they are safe for human beings and the environment. This study aimed to evaluate the entomopathogenic activity of fungi collected in the Amazon Rainforest against adult female Anopheles aquasalis mosquitoes. Females were exposed to four different species of fungi and observed daily to evaluate their survival rate. Also, fungi species' behavior was analyzed through scanning electron microscopy (SEM). Those exposed to Trichoderma harzianum and Penicillium citrinum had their survival rate reduced. SEM confirmed the development of fungi on the mosquitoes after 48 h. The findings suggest that the entomopathogenic potential of the fungi used in this study should be considered, given the reduction in the survival rate of Anopheles aquasalis mosquitoes.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass. 真菌共培养：释放木质纤维素生物质高效生物转化的潜力。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-17 DOI: 10.3390/jof11060458

Rafael Icaro Matos Vieira, Alencar da Silva Peixoto, Antonielle Vieira Monclaro, Carlos André Ornelas Ricart, Edivaldo Ximenes Ferreira Filho, Robert Neil Gerard Miller, Taísa Godoy Gomes

{"title":"Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass.","authors":"Rafael Icaro Matos Vieira, Alencar da Silva Peixoto, Antonielle Vieira Monclaro, Carlos André Ornelas Ricart, Edivaldo Ximenes Ferreira Filho, Robert Neil Gerard Miller, Taísa Godoy Gomes","doi":"10.3390/jof11060458","DOIUrl":"10.3390/jof11060458","url":null,"abstract":"Microbial decomposition of persistent natural compounds such as phenolic lignin and polysaccharides in plant cell walls plays a crucial role in the global carbon cycle and underpins diverse biotechnological applications. Among microbial decomposers, fungi from the Ascomycota and Basidiomycota phyla have evolved specialized mechanisms for efficient lignocellulosic biomass degradation, employing extracellular enzymes and synergistic fungal consortia. Fungal coculture, defined as the controlled, axenic cultivation of multiple fungal species or strains in a single culture medium, is a promising strategy for industrial processes. This approach to biomass conversion offers potential for enhancing production of enzymes, biofuels, and other high-value bioproducts, while enabling investigation of ecological dynamics and metabolic pathways relevant to biorefinery operations. Lignocellulosic biomass conversion into fuels, energy, and biochemicals is central to the bioeconomy, integrating advanced biotechnology with sustainable resource use. Recent advancements in -omics technologies, including genomics, transcriptomics, and proteomics, have facilitated detailed analysis of fungal metabolism, uncovering novel secondary metabolites and enzymatic pathways activated under specific growth conditions. This review highlights the potential of fungal coculture systems to advance sustainable biomass conversion in alignment with circular bioeconomy goals.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Bioactive Secondary Metabolites of Two Argentine Trichoderma afroharzianum Strains. 两株阿根廷非froharzium木霉次生代谢产物的生物活性研究。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-17 DOI: 10.3390/jof11060457

Rodrigo José Nunes Calumby, Antonella Santone, Estefanía Butassi, Laura Andrea Svetaz, Márcia de Souza Carvalho Melhem, Sebastián Pablo Rius, Valeria Alina Campos-Bermudez

{"title":"Exploring the Bioactive Secondary Metabolites of Two Argentine Trichoderma afroharzianum Strains.","authors":"Rodrigo José Nunes Calumby, Antonella Santone, Estefanía Butassi, Laura Andrea Svetaz, Márcia de Souza Carvalho Melhem, Sebastián Pablo Rius, Valeria Alina Campos-Bermudez","doi":"10.3390/jof11060457","DOIUrl":"10.3390/jof11060457","url":null,"abstract":"Trichoderma spp. produce diverse secondary metabolites with biological activity. This study explored the antimicrobial, antibiofilm, antioxidant, and cytotoxic properties of metabolites from two native Trichoderma strains, 10BR1 and UEPA AR12, isolated from rhizospheric soils. Organic extracts from both strains demonstrated broad-spectrum antimicrobial activity, inhibiting Gram-positive and Gram-negative bacteria, as well as various Candida species, with notable efficacy against Staphylococcus aureus (MICs: 15.6-31.25 µg/mL). The extracts also showed antibiofilm activity, with UEPA AR12 exhibiting the highest inhibition against Escherichia coli (81.8%), Enterococcus faecalis (92.8%), Candida albicans (87.9%), and Candida parapsilosis (89.3%). Antioxidant activity, assessed via DPPH assay, revealed a dose-dependent radical scavenging effect (12.88% to 39.67% at 7.8-1000 µg/mL). Cytotoxicity assays indicated that UEPA AR12 extracts were more cytotoxic (IC50: 202.5-234.3 µg/mL) than 10BR1 (IC50: 368.7-602.1 µg/mL) in non-tumor cells, with similar trends in tumor cells (Huh7). HPLC/MS analysis identified 21 metabolites in the extracts. Genomic analyses, supported by rpb2 gene and phylogenetic clustering, confirmed that both strains were T. afroharzianum. FUNGISMASH revealed multiple biosynthetic gene clusters, predominantly Type I polyketide synthase (T1PKS). Additionally, targeted genomic analyses did not detect mycotoxin-related genes. These findings highlight the antimicrobial, antibiofilm, and antioxidant potentials of these strains, positioning them as sources of bioactive metabolites for pharmaceutical applications.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Characterization of Mycelium-Based Composite Using Agro-Industrial Waste and Ganoderma lucidum as Insulating Material. 以工农业废弃物和灵芝为绝缘材料的菌丝体基复合材料的研制与表征。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-17 DOI: 10.3390/jof11060460

Gustavo Jiménez-Obando, Juan Sebastian Arcila, Ricardo Augusto Tolosa-Correa, Yenny Leandra Valencia-Cardona, Sandra Montoya

{"title":"Development and Characterization of Mycelium-Based Composite Using Agro-Industrial Waste and Ganoderma lucidum as Insulating Material.","authors":"Gustavo Jiménez-Obando, Juan Sebastian Arcila, Ricardo Augusto Tolosa-Correa, Yenny Leandra Valencia-Cardona, Sandra Montoya","doi":"10.3390/jof11060460","DOIUrl":"10.3390/jof11060460","url":null,"abstract":"Mycelium-based composites (MBCs) have emerged as eco-friendly alternatives, utilizing fungal mycelium as a natural binder for agro-industrial residues. This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to the Colombian-Venezuelan Andes with outstanding insulating properties, and natural fiber of Kikuyu grass (G) (Cenchrus clandestinus), utilizing Ganoderma lucidum as an agent to form a mycelium network in the MBC. Three formulations, T (100% A), F1 (70% A/30% G), and F2 (30% A/70% G), were evaluated under two different Arboloco particle size ranges (1.0 to 5.6 mm) for their physical, mechanical, and thermal properties. The Arboloco particle sizes did not show significant differences in the MBC properties. An increase in Kikuyu grass proportion (F2) demonstrated superior density (60.4 ± 4.5 kg/m3), lower water absorption (56.6 ± 18.4%), and better compressive strength (0.1686 MPa at 50% deformation). Both mixing formulations (F1-F2) achieved promising average thermal conductivity and specific heat capacity values of 0.047 ± 0.002 W m-1 K-1 and 1714 ± 105 J kg-1 K-1, comparable to commercial insulation materials. However, significant shrinkage (up to 53.6%) and high water absorption limit their scalability for broader applications. These findings enhance the understanding of MBC's potential for non-structural building materials made of regional lignocellulosic waste, promoting a circular economy in waste management for developing countries.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden Treasures of Colombia's Pacific Mangrove: New Fungal Species and Records of Macrofungi (Basidiomycota). 哥伦比亚太平洋红树林的隐藏宝藏：真菌新种和大型真菌（担子菌科）记录。

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-17 DOI: 10.3390/jof11060459

Viviana Motato-Vásquez, Lina Katherine Vinasco-Diaz, Jorge M Londoño-Caicedo, Ana C Bolaños-Rojas

{"title":"Hidden Treasures of Colombia's Pacific Mangrove: New Fungal Species and Records of Macrofungi (Basidiomycota).","authors":"Viviana Motato-Vásquez, Lina Katherine Vinasco-Diaz, Jorge M Londoño-Caicedo, Ana C Bolaños-Rojas","doi":"10.3390/jof11060459","DOIUrl":"10.3390/jof11060459","url":null,"abstract":"Mangrove-associated fungi represent a diverse but understudied group of eukaryotic organisms, especially in the Neotropics. The Colombian Pacific region, with approximately 1300 km of coastline covered with 194,880 ha of mangrove forests that remain largely unexplored for macrofungal diversity, is recognized as a global biodiversity hotspot. This study aimed to catalog the macrofungi associated with mangrove ecosystems in Colombia, integrating morphological characterization and molecular phylogenetics, focusing on three Valle del Cauca Pacific coast localities. A total of 81 specimens were collected from both living trees and decaying wood. Detailed macroscopic and microscopic analyses were conducted, and DNA sequences from two ribosomal DNA barcode regions (ITS and LSU) were generated for 43 specimens. Three new species-Neohypochnicium manglarense, Phlebiopsis colombiana, and Porogramme bononiae-were documented. In addition, eight species were reported as new records for both Colombia and mangrove ecosystems, including Microporus affinis, Paramarasmius palmivorus, Phlebiopsis flavidoalba, Porogramme brasiliensis, Resinicium grandisporum, Trametes ellipsospora, T. menziesii, and T. polyzona. Although previously recorded in Colombian terrestrial ecosystems, Lentinus scleropus and Oudemansiella platensis are globally reported here for the first time from mangrove habitats. Furthermore, Fomitopsis nivosella and Punctularia strigosozonata were documented for the first time in Colombia. This study addresses the first exploration of mangrove-associated macrofungi in the country and provides new insights into the hidden fungal diversity and potential of mangrove ecosystems as a latent niche for basidiomycete dispersal along Colombia's Pacific coast.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Experience with Isavuconazole for Invasive Aspergillosis in Hematologic Patients with and Without COVID-19 in Brazil. Isavuconazole在巴西治疗COVID-19和非COVID-19血液病患者侵袭性曲霉病的实际经验

IF 4.2 2区生物学

Journal of Fungi Pub Date : 2025-06-16 DOI: 10.3390/jof11060456

Larissa Simão Gandolpho, Vinicius Ponzio, Marjorie Vieira Batista, Ivan Leonardo Avelino França E Silva, Jessica Fernandes Ramos, Marcio Nucci, Arnaldo Lopes Colombo

{"title":"Real-World Experience with Isavuconazole for Invasive Aspergillosis in Hematologic Patients with and Without COVID-19 in Brazil.","authors":"Larissa Simão Gandolpho, Vinicius Ponzio, Marjorie Vieira Batista, Ivan Leonardo Avelino França E Silva, Jessica Fernandes Ramos, Marcio Nucci, Arnaldo Lopes Colombo","doi":"10.3390/jof11060456","DOIUrl":"10.3390/jof11060456","url":null,"abstract":"(1) Background: Invasive aspergillosis is a life-threatening fungal infection, particularly in patients with hematologic malignancies. Isavuconazole, a broad-spectrum triazole, has emerged as a key treatment option, but real-world data in high-risk populations from middle-income countries remain limited. (2) Methods: We conducted a multicenter, retrospective study to evaluate the clinical response rate and tolerability of isavuconazole in patients with hematologic malignancies and probable or proven invasive aspergillosis across four medical centers in Brazil. (3) Results: We enrolled 50 patients aged 18 to 82 years (64% male) with proven or probable invasive aspergillosis, diagnosed in the context of complex hematologic conditions. Among them, 60% had active or refractory malignancies, and 22% had a prior COVID-19 infection. Isavuconazole was used as a first-line therapy in 64% of cases. No patients discontinued treatment due to toxicity. The 6-week overall survival was 60%. Prior COVID-19 infection was associated with a lower survival rate (44% vs. 69% in patients without COVID-19, p = 0.04). (4) Conclusions: This study provides real-world evidence supporting the efficacy and tolerability of isavuconazole in a high-risk population. The findings reinforce its role as a key antifungal therapy, particularly in patients with complex underlying conditions.","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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