Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Evaluating the efficacy of transcutaneous electrical nerve stimulation in managing chronic pelvic pain in endometriosis patients","authors":"Maylis Robin ,&nbsp;Camille Durand ,&nbsp;Léa Roux ,&nbsp;Isabelle Berkelmans ,&nbsp;Benoit Peyronnet ,&nbsp;Charlène Brochard ,&nbsp;Ludivine Dion ,&nbsp;Vincent Lavoué ,&nbsp;Jean Levêque ,&nbsp;Maela Le Lous ,&nbsp;Krystel Nyangoh Timoh","doi":"10.1016/j.jogoh.2026.103130","DOIUrl":"10.1016/j.jogoh.2026.103130","url":null,"abstract":"<div><h3>Introduction</h3><div>This study sought to assess the impact of transcutaneous electrical nerve stimulation (TENS) prescribed by gynecologists in routine practice on pain, pelvic sensitization, quality of life, and catastrophization scores in patients with endometriosis and chronic pelvic pain.</div></div><div><h3>Methods</h3><div>Thirty patients at the University Hospital of Rennes, France, diagnosed with endometriosis and experiencing chronic pelvic pain, received TENS between September 2022 and February 2023. Pain, pelvic sensitization, quality of life, catastrophization, and Brief Pain Inventory (BPI) were assessed using standardized and validated questionnaires before and after 1, 3, and 6 months of TENS device use.</div></div><div><h3>Results</h3><div>After 1 month of device use, minimal changes occurred as improvement in the perception of treatment effectiveness by patients, sleep quality, and well-being (BPI). However, after 3 months, a significant improvement was observed in all these measures, which persisted at 6 months. Specifically, pain intensity (numerical rating scale) significantly decreased (<em>p</em> = 0.029), pelvic sensitization decreased (<em>p</em> = 0.039), quality of life assessed by the EHP-5 score improved (<em>p</em> = 0.003), and catastrophization scores significantly decreased (<em>p</em> = 0.003). Patients also reported a notable improvement in their perception of treatment effectiveness, particularly in terms of its impact on work and interactions with others (BPI).</div></div><div><h3>Conclusions</h3><div>TENS prescribed by gynecologists in routine practice may be effective in reducing pain, pelvic sensitization, and improving quality of life and catastrophization scores in patients with endometriosis and chronic pelvic pain. These findings are very useful in daily practice, especially for patients waiting for pain management physicians.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103130"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide exposure in early pregnancy and pregnancy outcomes: A case report and review of literature","authors":"Yuan-Cheng Jin ,&nbsp;Yu-Hua Wu ,&nbsp;Xue-Song Ma ,&nbsp;Wen Shi ,&nbsp;Miao-Lian Wu ,&nbsp;Qing-Qing Hu","doi":"10.1016/j.jogoh.2026.103133","DOIUrl":"10.1016/j.jogoh.2026.103133","url":null,"abstract":"<div><h3>Background</h3><div>Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used for the treatment of diabetes and weight loss, including in women of reproductive age. However, its impact on pregnancy outcomes remains largely unknown, with limited data available. The manufacturer advises against using semaglutide within two months prior to planned pregnancy, but some patients may unknowingly use it during early pregnancy.</div></div><div><h3>Case Presentation</h3><div>We report the case of a 37-year-old woman with a pre-pregnancy Body Mass Index (BMI) of 27.73 kg/m². She received semaglutide 0.5 mg once weekly, initiated before conception and continued until approximately 7 weeks of gestation, and discontinued treatment immediately upon recognition of pregnancy. All prenatal screenings, including nuchal translucency and four-dimensional color Doppler ultrasound, were normal. She delivered a healthy male infant at nearly 40 weeks of gestation. The infant showed no adverse outcomes during follow-up assessments at 1 and 3 months of age.</div></div><div><h3>Conclusions</h3><div>This case suggests that semaglutide exposure during early pregnancy may not necessarily lead to adverse outcomes in obese women. However, larger studies are needed to confirm these findings and to better understand the impact of semaglutide on pregnancy outcomes. This case report contributes to the limited literature on this topic and may inform future clinical decision-making.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103133"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of air pollution exposure with anti-Müllerian hormone as an ovarian reserve biomarker: A systematic review","authors":"Leila Mandalou ,&nbsp;Ali Aghebati-Maleki ,&nbsp;Amirhossein Mardi ,&nbsp;Mehdi Yousefi ,&nbsp;Leili Aghebati-Maleki","doi":"10.1016/j.jogoh.2026.103127","DOIUrl":"10.1016/j.jogoh.2026.103127","url":null,"abstract":"<div><h3>Background</h3><div>Reproductive health is essential to women's well-being. Rising infertility rates are influenced by environmental and lifestyle factors. Aging significantly reduces ovarian reserve and oocyte quality, especially after age 35. Anti-Müllerian hormone (AMH) is a reliable marker for assessing ovarian reserve. Air pollution, particularly exposure to particulate matter (PM) and nitrogen oxides (NOx), may be negatively associated with ovarian reserve and reproductive health.</div></div><div><h3>Objectives</h3><div>To evaluate current evidence on the effects of air pollution on AMH levels.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, and Web of Science for studies published from January 2000 until December 29, 2024, using specific keywords. Two reviewers independently screened studies based on predefined inclusion criteria, focusing on original articles examining the relationship between air pollutants and AMH levels. Data were extracted using Google Sheets. Study quality was assessed using the AXIS tool for cross-sectional studies and the Newcastle-Ottawa Scale for cohort studies.</div></div><div><h3>Results</h3><div>Twelve studies were included. Nine reported a significant association between air pollution and reduced AMH levels. The methodological quality of studies ranged from fair to good, supporting the robustness of findings.</div></div><div><h3>Conclusion</h3><div>Air pollution may significantly reduce ovarian reserve. Reducing exposure to PM2.5 and NOx is crucial for fertility preservation, especially in polluted urban areas.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103127"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"vNOTES (vaginal natural orifice transluminal surgery) gynecological procedures in morbidly obese patients BMI≥40kg/m2: An experience in a Southeast Asian tertiary centre","authors":"Sandra Lynn Jaya-Bodestyne,&nbsp;Ashton Kai Sheng Yin,&nbsp;Christopher Jer Wei Low,&nbsp;Ashley Shuen Ying Hong,&nbsp;Yvonne Wan Yu Wong,&nbsp;Joella Xiaohong Ang,&nbsp;Jason Shau Khng Lim,&nbsp;Ravichandran Nadarajah","doi":"10.1016/j.jogoh.2026.103128","DOIUrl":"10.1016/j.jogoh.2026.103128","url":null,"abstract":"<div><h3>Introduction</h3><div>Vaginal natural orifice transluminal surgery (vNOTES) is a promising tool in gynecology and is being increasingly adopted in minimally invasive surgery. The aim of this study is to assess the feasibility and outcomes of vNOTES for morbidly obese patients for gynecological surgeries.</div></div><div><h3>Material and methods</h3><div>Morbidly obese patients (BMI≥40kg/m²) who underwent vNOTES for gynecological conditions from March 2021 to June 2025 were identified. Data on patient demographics, operative factors, complications and postoperative outcomes were collected and analyzed. A literature review on gynecology vNOTES in morbidly obese patients was also performed.</div></div><div><h3>Results</h3><div>32 patients were identified. The median BMI was 42.1kg/m² (range 40.0 – 72kg/m²). Their age ranged from 23 to 77 years old. 50% of them had a previous abdominal or pelvic surgery. 50% were nulliparous. The most common procedure performed was total hysterectomy bilateral salpingoophorectomy (81.3%). One patient underwent pelvic lymph node dissection. The median operative time was 150mins (range 75 – 475mins). The median blood loss was 200mL (range 0 – 1700mL). The median length of stay was 2 days (range 1 – 38 days) and postoperative pain scores were low. One patient developed a postoperative pelvic collection that was treated conservatively. In the literature review comparing 3 other studies, the perioperative and postoperative complication rates and median operation time were generally comparable, although this interpretation is limited by the small sample sizes.</div></div><div><h3>Conclusion</h3><div>vNOTES is a feasible approach in morbidly obese patients for various gynaecological surgeries, demonstrating favourable outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103128"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting endometrial stem cell in endometriosis treatment, a scoping review","authors":"Maria João Carvalho ,&nbsp;Fernanda Santos ,&nbsp;Vanessa Vieira ,&nbsp;Bárbara Laranjeiro ,&nbsp;Carlota Anjinho-Carvalhos ,&nbsp;Ana Aparício ,&nbsp;Mariana Robalo-Cordeiro ,&nbsp;Margarida Figueiredo-Dias","doi":"10.1016/j.jogoh.2026.103123","DOIUrl":"10.1016/j.jogoh.2026.103123","url":null,"abstract":"<div><h3>Introduction</h3><div>Endometriosis is characterized by the ectopic implantation of endometrial tissue affecting reproductive-aged women. Available therapies have still unmet needs namely due to recurrence rates and systemic side effects. Emerging evidence suggests endometrial stem cells (EnSCs) contribution in disease pathogenesis, including mesenchymal stem cells (E-MSCs), epithelial progenitor cells (EPCs), and side population cells (ESPs). These stem/progenitor cells are involved in proliferation, migration, and angiogenesis, contributing to endometriosis genesis and persistence. Targeting EnSCs and their regulatory pathways present a promising therapeutic strategy to improve unmet needs in endometriosis.</div></div><div><h3>Materials and Methods</h3><div>This scoping review was based on a systematic literature search conducted in PubMed, EMBASE, and Web of Science considering studies published after 2000. Inclusion criteria focused on original research articles exploring the role and targeting of EnSCs in endometriosis, following PRISMA-ScR guidelines. Data were synthesized through narrative and descriptive methods.</div></div><div><h3>Results</h3><div>The review structures key pathways and therapeutic agents targeting EnSCs in endometriosis. Notch1, PI3K/Akt, Wnt/β-catenin, and JAK/STAT signalling are pathways that regulate proliferation, migration and survival of EnSCs in endometriosis. Agents such as metformin, lovastatin, sorafenib, quinagolide, and γ-secretase inhibitors demonstrated potential to modulate stemness, leading to a decrease in inflammation, migration and apoptosis. Anti-angiogenic agents showed efficacy in reducing lesion size <em>In vivo</em>, targeting E-MSCs. Exosomes emerge as a cell-free approach, derived from menstrual stem cells (MenSCs) or ginger-based nanoparticles and exhibited properties essential for endometriosis treatment, directed to ectopic stem cells.</div></div><div><h3>Conclusions</h3><div>EnSCs sustain aberrant cellular behaviours in endometriosis. Targeting EnSCs and their related pathways may be an innovative, individualized, and disease-modifying strategy. Pharmacological modulation, gene therapy and exosome are strategies for stem cell inhibition in endometriosis, being a promising avenue for future research leading to application in clinical practice.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103123"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to perform unilateral pectineal suspension for apical prolapse by robotic assistance: A technical note with Video","authors":"Gery Lamblin ,&nbsp;Graziella Moufawad ,&nbsp;Chloé Miguet-Bensouda ,&nbsp;Maiti Alefsen-de-Boisredon ,&nbsp;Charles-André Philip ,&nbsp;Erdogan Nohuz ,&nbsp;Laurent de Landsheere","doi":"10.1016/j.jogoh.2026.103122","DOIUrl":"10.1016/j.jogoh.2026.103122","url":null,"abstract":"<div><div>Sacrocolpopexy remains the gold-standard surgical technique for the management of apical prolapse, whether performed with or without concomitant hysterectomy. However, the use of synthetic mesh has become increasingly debated owing to concerns regarding postoperative complications. Robotic-assisted unilateral pectineal suspension (UPS) has emerged as an innovative, safe, and effective alternative for apical prolapse repair. This minimally invasive, mesh-free procedure achieves uterine suspension by anchoring the anterior cervical surface to Cooper’s iliopectineal ligament. Indications include women of reproductive age seeking a uterus-preserving approach, obese patients, and those unwilling to undergo procedures involving synthetic prostheses; it may also represent a suitable option in selected cases of recurrence following laparoscopic sacrocolpopexy or vaginal repair. We describe the standardized steps of this surgical procedure, along with the specific advantages of the robotic approach, illustrated by a detailed video demonstration to support implementation among surgeons.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103122"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of symptom improvement over time after fractional CO2 laser therapy in women with genito-urinary syndrome","authors":"FABBRO Laurine ,&nbsp;LELOUBE Simon ,&nbsp;MONIOD Louise ,&nbsp;FABBRO Pascale ,&nbsp;CHAULEUR Céline","doi":"10.1016/j.jogoh.2026.103121","DOIUrl":"10.1016/j.jogoh.2026.103121","url":null,"abstract":"<div><h3>Introduction</h3><div>Genitourinary Syndrome of Menopause (GSM) results from reduced estrogen levels, typically postmenopausally or after hormone-dependent cancer. It manifests with vulvovaginal (dryness, itching, burning), sexual (dyspareunia), and urinary (infections, incontinence) symptoms, severely affecting quality of life. For women who cannot use hormonal treatments or are unresponsive to them, CO₂ laser therapy offers a potential alternative.</div></div><div><h3>Objective</h3><div>This study aimed to assess short- and long-term symptom improvement and sexual quality of life following CO₂ laser treatment for genito-urinary syndrome.</div></div><div><h3>Method</h3><div>A prospective, monocentric symptom improvement survey was conducted at the Saint-Étienne University Hospital between July 2019 and August 2023 with 138 patients. It was assessed using visual analogue scales (VAS) and the Female Sexual Distress Scale-Revised (FSDS-R) before treatment, one month after each session, and 10–24 months post-treatment.</div></div><div><h3>Results</h3><div>One month after treatment, significant improvements (<em>p</em> &lt; 0.0001) were noted in all GSM symptoms and sexual quality of life. These improvements remained significant at long-term follow-up (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Fractional CO₂ laser therapy is an effective, durable treatment for GSM in postmenopausal women or those with hormone-dependent cancer, significantly improving urogenital quality of life.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103121"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in interpreting Doppler ultrasound for prolonged pregnancy: Key limitations and future research directions","authors":"Yan Li,&nbsp;Chunling Ma,&nbsp;Chao Li","doi":"10.1016/j.jogoh.2026.103126","DOIUrl":"10.1016/j.jogoh.2026.103126","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103126"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feasibility study of flipped classroom and TeamSTEPPS integration for obstetrical emergency simulations: Insights from the PARTUM group study","authors":"V. Balaya ,&nbsp;D. Desseauve ,&nbsp;A. Farin ,&nbsp;C. Daelemans ,&nbsp;P.F. Ceccaldi ,&nbsp;PARTUM group","doi":"10.1016/j.jogoh.2026.103114","DOIUrl":"10.1016/j.jogoh.2026.103114","url":null,"abstract":"<div><h3>Objectives</h3><div>The primary objective was to assess the internal correlations between TeamSTEPPS behavioral domains as perceived by learners evaluating faculty performance. The secondary objective was to explore the feasibility and reproducibility of a flipped classroom model applied to interprofessional simulation-based obstetrical training.</div></div><div><h3>Material and methods</h3><div>This study is an ancillary analysis of the PARTUM training program <em>(«</em> <strong><em>P</em></strong><em>rise en charge des</em> <strong><em>A</em></strong><em>ccouchements à</em> <strong><em>R</em></strong><em>isque e</em><strong><em>T</em></strong> <em>des</em> <strong><em>U</em></strong><em>rgences</em> <strong><em>M</em></strong><em>aternelles», Management of High-risk delivery and obstetrical emergencies</em>). Within the flipped classroom framework, learners designed a practical case involving a pregnant woman experiencing a local anesthetics overdose during labor. Two groups of teachers were evaluated by learners according to the modified Teamwork attitude questionnaire, consisting of 16 items rated from 1 (“very below expectations”) to 5 (“very above expectations”).</div></div><div><h3>Results</h3><div>The PARTUM 2022 session included seven teachers and eighteen learners. In the pooled analysis, three items among the 16 of the Teamwork attitude questionnaire (TAQ) were found to be below expectations with a mean score lower than 3: check-back using (<em>m</em> = 2.75 ± 0.84), callouts using (<em>m</em> = 2.91 ± 0.81) and appropriate task delegation or assignments (<em>m</em> = 2.95 ± 0.74). No significant differences were found between groups 1 and 2. Leadership was strongly correlated to team structure (<em>r</em> = 0.701, <em>p</em> &lt; 0.001), situation monitoring (<em>r</em> = 0.651, <em>p</em> = 0.001), and team communication (<em>r</em> = 0.576, <em>p</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>This study showed that a flipped classroom simulation was feasible and reproducible for interprofessional teaching of obstetric emergencies. Leadership appeared as the cornerstone of the teamwork</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103114"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding of trisomy 21 prenatal screening among pregnant women in France: A cross-sectional study in light of 2019 guidelines","authors":"Clément Wulveryck ,&nbsp;Eva Van Steijvoort ,&nbsp;Nicolas Sananès ,&nbsp;Romain Demailly ,&nbsp;Paulo Rodrigues","doi":"10.1016/j.jogoh.2026.103109","DOIUrl":"10.1016/j.jogoh.2026.103109","url":null,"abstract":"<div><h3>Objective</h3><div>Cell-free DNA (cfDNA) screening test has been reimbursed in France since 2019 as part of the national trisomy 21 (T21) screening program. The expansion of cfDNA sequencing in September 2024 to include additional chromosomal anomalies raises new challenges for information delivery and informed consent. This study aimed to assess pregnant women’s understanding of trisomy 21 prenatal screening information, distinct from satisfaction with or access to information, in light of these developments.</div></div><div><h3>Study design</h3><div>A cross-sectional online survey was conducted in August–September 2024 among women aged ≥18 years who had experienced at least one pregnancy since January 2019. Participants were recruited via Instagram and targeted mailing. The questionnaire assessed participants perceptions of the clarity, completeness, and sufficiency of T21 screening information, and included five open-ended questions to assess objective understanding. A comprehension score (0–10) was calculated using semantic analysis (BERT model) and predefined criteria. Associations between comprehension and sociodemographic factors were examined.</div></div><div><h3>Results</h3><div>Among 2,146 respondents, 94.5 % received information from a healthcare professional. Within this group, 35.6 % sought additional sources. Only 43.8 % judged the information as very clear, and less than 30 % considered it sufficient or complete. The median comprehension score was 2.6 out of 10. Misconceptions were common, notably the confusion between screening and diagnosis. Higher comprehension was significantly associated with full-time employment (p = .001), higher education level (p &lt; .001), and multiparity (p = .003).</div></div><div><h3>Conclusion</h3><div>Although most women received information from a healthcare professional, both their perceived and actual comprehension of trisomy 21 screening, especially regarding cfDNA screening test, remained limited. These findings highlight the need for improved communication tools and tailored support to ensure informed decision-making across diverse populations.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 4","pages":"Article 103109"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}