Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Development and temporal validation of a deep learning model for automatic fetal biometry from ultrasound videos","authors":"M. Goetz-Fu ,&nbsp;M. Haller ,&nbsp;T. Collins ,&nbsp;N. Begusic ,&nbsp;F. Jochum ,&nbsp;Y. Keeza ,&nbsp;J. Uwineza ,&nbsp;J. Marescaux ,&nbsp;A.S. Weingertner ,&nbsp;N. Sananès ,&nbsp;A. Hostettler","doi":"10.1016/j.jogoh.2025.103039","DOIUrl":"10.1016/j.jogoh.2025.103039","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective was to develop an artificial intelligence (AI)-based system, using deep neural network (DNN) technology, to automatically detect standard fetal planes during video capture, measure fetal biometry parameters and estimate fetal weight.</div></div><div><h3>Methods</h3><div>A standard plane recognition DNN was trained to classify ultrasound images into four categories: head circumference (HC), abdominal circumference (AC), femur length (FL) standard planes, or ‘other’. The recognized standard plane images were subsequently processed by three fetal biometry DNNs, automatically measuring HC, AC and FL. Fetal weight was then estimated with the Hadlock 3 formula. The training dataset consisted of 16,626 images. A prospective temporal validation was then conducted using an independent set of 281 ultrasound videos of healthy fetuses. Fetal weight and biometry measurements were compared against an expert sonographer. Two less experienced sonographers were used as controls.</div></div><div><h3>Results</h3><div>The AI system obtained a significantly lower absolute relative measurement error in fetal weight estimation than the controls (AI vs. medium-level: <em>p</em> = 0.032, AI vs. beginner: <em>p</em> &lt; 1e-8), so in AC measurements (AI vs. medium-level: <em>p</em> = 1.72e-04, AI vs. beginner: <em>p</em> &lt; 1e-06). Average absolute relative measurement errors of AI versus expert were: 0.96 % (S.D. 0.79 %) for HC, 1.56 % (S.D. 1.39 %) for AC, 1.77 % (S.D. 1.46 %) for FL and 3.10 % (S.D. 2.74 %) for fetal weight estimation.</div></div><div><h3>Conclusion</h3><div>The AI system produced similar biometry measurements and fetal weight estimation to those of the expert sonographer. It is a promising tool to enhance non-expert sonographers’ performance and reproducibility in fetal biometry measurements, and to reduce inter-operator variability.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103039"},"PeriodicalIF":1.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetrics and gynecology residents’ preparedness to perform essential obstetric procedures autonomously: A national survey among French residents and teachers","authors":"Laura Puroski ,&nbsp;Salma Touleimat ,&nbsp;Patrice Crochet ,&nbsp;Olivia Guerin ,&nbsp;Jean-michel Coq ,&nbsp;Eric Verspyck ,&nbsp;Sophia Braund","doi":"10.1016/j.jogoh.2025.103038","DOIUrl":"10.1016/j.jogoh.2025.103038","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the self-evaluation of French residents and the opinion of academic teachers regarding the autonomy granted during residents’ training and the level of preparation achieved at the end of the residency to perform essential obstetric procedures.</div></div><div><h3>Methods</h3><div>A national survey of French obstetrics and gynecology residents and their academic teachers was conducted using an online questionnaire distributed in 2023, which gathered the self-evaluation by residents and opinion of academic teachers on the level of autonomy for essential obstetric procedures and perceptions of preparedness upon graduation. The survey also examined perceptions on the impact of factors that improve autonomy.</div></div><div><h3>Results</h3><div>510 of the 1197 (43%) residents and 49 of the 137 academic teachers (36%) completed the questionnaire. Both residents and academic teachers were confident that residents would be prepared at the end of residency to perform most essential obstetric procedures, including vacuum and forceps or spatula assisted vaginal delivery. However, regarding advanced obstetric surgery in case of severe postpartum hemorrhage (PPH), only 36% of 6th-year residents reported feeling capable of performing a uterine artery ligation in case of an emergency, and 11% in performing a hemostatic hysterectomy. Main factors that were perceived as important for improving autonomy were the number of cases and the quality of coaching.</div></div><div><h3>Conclusion</h3><div>French residents reported a gradual increase in autonomy throughout their residency for the majority of essential obstetric procedures, with the exception of surgical management of severe PPH. Teachers shared a similar opinion. Simulation and the quality of supervision appear to be promising pathways for enhancing their autonomy.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103038"},"PeriodicalIF":1.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential and mechanism of mesenchymal stem cells in the treatment of premature ovarian failure","authors":"Wei-Ran Jin ,&nbsp;Shu-Yang He ,&nbsp;Xian-Xian Mao ,&nbsp;Jing-Yuan Li ,&nbsp;Xiang-Cheng Zhang ,&nbsp;Quan-Wen Liu","doi":"10.1016/j.jogoh.2025.103031","DOIUrl":"10.1016/j.jogoh.2025.103031","url":null,"abstract":"<div><div>Premature ovarian failure (POF), a common endocrine disorder, pertains to the loss of ovarian function in women under the age of 40 years. It is clinically characterized by estrogen deficiency with increased gonadotropin level and amenorrhea, which can lead to loss of fertility and increase the risk of other diseases, including cardiovascular disorders, osteoporosis, and mood disorders. Currently, the most common treatment is hormone replacement therapy (HRT), it relieves menopausal symptoms but does not improve the function of the ovary. Mesenchymal stem cells (MSCs) share the ability of self-renewal and differentiation, playing an important role in the regeneration of injured tissues. Notably, accumulating evidence indicates that MSCs primarily exert their effects through paracrine interactions with the ovarian cortex, rather than contributing to de novo oocyte generation. This suggests that ovarian exhaustion is not complete in POF, leaving a residual ovarian environment that allows MSCs to act. So far, many reports have demonstrated that transplantation of MSCs can improve ovarian structure and function, promote follicular development, and restore hormone levels by anti-apoptosis, promoting angiogenesis, immunomodulation, and anti-oxidation, suggesting the potential of MSCs as alternative therapeutics for POF. Therefore, this study aims to summarize the latest findings on the mechanism and application of MSCs in POF treatment, providing directions for continued research and clinical therapy.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103031"},"PeriodicalIF":1.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of the CAESARE tool in the management of non-reassuring fetal status at risk of acidosis","authors":"Simon Hubert ,&nbsp;Océane Brodbeck ,&nbsp;Fares Ghrairi ,&nbsp;Amjad Kattini ,&nbsp;Jan Chrusciel ,&nbsp;Stéphane Sanchez","doi":"10.1016/j.jogoh.2025.103037","DOIUrl":"10.1016/j.jogoh.2025.103037","url":null,"abstract":"<div><h3>Introduction</h3><div>Developed in 2020, the CAESARE tool is a decision-support tool for interpreting fetal heart rate (FHR). In a preliminary study, the use of CAESARE led to a significant reduction in caesarean section rates.</div></div><div><h3>Methods</h3><div>We assessed the ability of the CAESARE tool to predict acidosis earlier by reducing the time-to-intervention in cases of non-reassuring fetal status (NRFS). We performed a retrospective, single-center case-control analysis evaluating associations between CAESARE scoring and the onset of neonatal acidosis. The primary outcome was presence or absence of fetal acidosis at birth based on CAESARE score. The case population was patients whose fetuses had fetal heart rate abnormalities and an arterial pH &lt; 7.00 at birth. The control population was patients who had fetal heart rate abnormalities without the fetuses having acidosis at birth.</div></div><div><h3>Results</h3><div>CAESARE influenced decisions regarding the continuation of labor. It was associated with increased end of labor in the case group (<em>p</em> &lt; 0.01) and greater expectant management in the control group (<em>p</em> &lt; 0.01). CAESARE sensitivity and specificity were 0.97 and 0.88, respectively.</div></div><div><h3>Conclusion</h3><div>In our study, 32.1% of neonatal acidosis cases could have potentially been avoided if CAESARE had been used. The tool enabled extended expectant management in 42% of cases where end of labor was recommended. These findings support the implementation of a procedure for improved FHR analysis practices.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103037"},"PeriodicalIF":1.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to detect and remove deep or nonpalpable contraceptive implants ? A technical note","authors":"Gautier Chene ,&nbsp;Ana Gjorgjievska-Delov ,&nbsp;Anthony Atallah ,&nbsp;Alexandra Ohannessian ,&nbsp;Emanuele Cerruto ,&nbsp;Erdogan Nohuz","doi":"10.1016/j.jogoh.2025.103036","DOIUrl":"10.1016/j.jogoh.2025.103036","url":null,"abstract":"<div><div>Removing deep subcutaneous contraceptive implants is a challenge. Despite modifications to the inserter and insertion site, the prevalence of deep implants is still estimated at 1/1000. In this technical note, we describe strategies for safely locating and removing deep implants.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103036"},"PeriodicalIF":1.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the M6P model in predicting ectopic pregnancy among pregnancies of unknown location: A prospective monocentric study in Tunisia","authors":"Wissal Jaafar ,&nbsp;Ferdaous Mellouli ,&nbsp;Hamdi Dhaouadi ,&nbsp;Yasmine Chiba ,&nbsp;Malak Medemagh ,&nbsp;Mehdi Bouassida ,&nbsp;Nahed Khalifa ,&nbsp;Mechaal Mourali","doi":"10.1016/j.jogoh.2025.103035","DOIUrl":"10.1016/j.jogoh.2025.103035","url":null,"abstract":"<div><h3>Introduction</h3><div>Pregnancy of unknown location (PUL) refers to a positive pregnancy test without definitive ultrasound evidence of intrauterine or ectopic pregnancy. It present a diagnostic challenge in early pregnancy management due to the risk of ectopic pregnancy (EP).</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted on 179 women presenting with PUL. We assessed the predictive accuracy of the M6P model and analyzed its performance compared to standard clinical, biological, and ultrasound parameters among patients with PUL in a Tunisian population.</div></div><div><h3>Results</h3><div>The M6P model showed promising performance in stratifying EP risk factors significantly associated with high-risk EP included history of ectopic pregnancy, intrauterine device use, history of pelvic inflammatory disease, and smoking.</div></div><div><h3>Conclusion</h3><div>The M6P model is a valuable, objective, and reproducible tool for early risk stratification in PUL, with potential to reduce unnecessary hospitalizations and improve patient care.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103035"},"PeriodicalIF":1.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nine-step standard operating procedure for uterine preservation in placenta accreta spectrum: 7-year experience in a Chinese tertiary hospital","authors":"Zhixia Wei ,&nbsp;Li Feng ,&nbsp;Xiaomin Yang ,&nbsp;Hailan Yang","doi":"10.1016/j.jogoh.2025.103032","DOIUrl":"10.1016/j.jogoh.2025.103032","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate risk factors for adverse outcomes in the placenta accreta spectrum (PAS) and assess the efficacy of a nine-step uterus-sparing cesarean section protocol compared with traditional approaches.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 137 women with PAS who underwent cesarean delivery between 2016 and 2022. Participants were stratified into nine-step surgery (<em>n</em> = 26) and conventional surgery (<em>n</em> = 111) groups. The allocation of patients in each group was based on surgeon experience and surgical team’s intraoperative judgment. The protocol integrates placental mapping, transient uterine ischemia, delayed vascular control, and multilayer reconstruction. Machine learning (SMOTE-enhanced Random Forest) was used to identify the predictors of hemorrhage and hysterectomy.</div></div><div><h3>Results</h3><div>The nine-step surgery group reduced the hysterectomy rate to 1.9 % vs. 9.0 % in the control group (<em>P</em> &lt; 0.001), with fewer severe complications (hemorrhagic shock: 3.8 % vs. 12.6 %; DIC: 1.9 % vs. 8.1 %). Multivariate logistic regression analysis confirmed that nine-step surgery was independently related to a lower probability of hysterectomy (<em>P</em> = 0.050) (odds ratio: 0.107, 95 %CI: 0.011, 0.998). Gravidity (Gini=3.809) and pathological placental adhesion (PPA) were key hemorrhage predictors. The hysterectomy prediction model achieved exceptional discrimination (AUC=0.993), driven by intraoperative blood loss (Gini=16.068) and PPA severity. Experienced teams preserved 83.3 % of the uterus, compared to 63.0 % in the less-experienced group (<em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>The nine-step uterine preservation protocol significantly reduced the hysterectomy rate in the PAS through dynamic risk stratification and staged hemostasis. Integrated machine learning models enhance precision management, enabling fertility preservation while minimizing the risk of severe complications.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 1","pages":"Article 103032"},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullying and burnout in French obstetrics and gynecology residency programs: a national cross-sectional study","authors":"Chloé Gaillard ,&nbsp;Camille Durand ,&nbsp;Marie Allegrini ,&nbsp;Estelle Le Pabic ,&nbsp;Estelle Michinov ,&nbsp;Ludivine Dion ,&nbsp;Vincent Lavoué ,&nbsp;Jean Levêque ,&nbsp;Linda Lassel ,&nbsp;Maela Le Lous ,&nbsp;Krystel Nyangoh Timoh","doi":"10.1016/j.jogoh.2025.103034","DOIUrl":"10.1016/j.jogoh.2025.103034","url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research has demonstrated high burnout rates during medical residency, namely among obstetrics and gynecology (Ob-Gyn) specialists. Concurrently, reports of workplace bullying, particularly in surgical wards, have risen. However, no studies have evaluated these aspects among French Ob-Gyn residents. This study assessed the prevalence and impact of workplace bullying on Ob-Gyn residents, the relationship between bullying and burnout, and the risk and protective factors influencing burnout.</div></div><div><h3>Methods</h3><div>A national, observational, cross-sectional study was conducted involving 37 French Ob-Gyn residency programs during the 2021–2022 academic year. Data were collected via an anonymous online survey using instruments such as the Maslach Burnout Inventory, Negative Acts Questionnaire-Revised (NAQ-R), and Hospital Anxiety and Depression Scale. Sociodemographic data, working conditions, sources/locations of bullying, and incidence of suicidal ideation were also collected. Multivariable logistic regression was used to analyze associations.</div></div><div><h3>Results</h3><div>Of 625 respondents, 52.4% reported bullying as measured by the NAQ-R. Burnout was present in 18.4%, with notable rates of professional exhaustion (24.3%), depersonalization (34.9%), and diminished personal accomplishment (25.1%). A significative correlation between workplace bullying and burnout was found. Strong social support from superiors emerged as protective against burnout, whereas frequent exposure to bullying, excessive working hours, and high stress levels were identified as major risk factors.</div></div><div><h3>Conclusion</h3><div>Our study reveals that 52.5% of responding residents reported experiencing workplace bullying, and 18.4% met the criteria for burnout. While these findings are concerning and warrant attention, they reflect the experiences of residents who chose to participate in the survey, and may therefore overrepresent those most affected. Nevertheless, the significant association observed between bullying and burnout highlights the need for institutional strategies to better support residents' well-being and ensure a safe, respectful working environment in obstetrics and gynecology residency programs.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103034"},"PeriodicalIF":1.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long hours, limited rest: a national snapshot of ObGyn resident work conditions in France and paths to reform","authors":"Charline Bertholdt ,&nbsp;Nadia Magroune ,&nbsp;Anne-Laure Fijean ,&nbsp;Mikaël Agopiantz ,&nbsp;Kévin Guillez ,&nbsp;Matthieu Dap ,&nbsp;Olivier Morel","doi":"10.1016/j.jogoh.2025.103033","DOIUrl":"10.1016/j.jogoh.2025.103033","url":null,"abstract":"<div><h3>Objectives</h3><div>The main aim was to describe the weekly working time of French ObGyn residents. As secondary objectives, we aimed to evaluate the respect of training time and day off for safety and finally, to describe proposed adjustments to respect maximal weekly working time.</div></div><div><h3>Methods</h3><div>This national descriptive survey was addressed among ObGyn residents in 2024. The primary outcome was the average weekly working time declared by all residents. For the secondary outcomes, we assessed the mean number of weekday and weekend on-call, the rate of applicability of day off after on-call, the rate of presence of training days and the description of modalities proposed regarding additional day off to respect working time.</div></div><div><h3>Results</h3><div>413 responses were obtained with 92.8 % of universities represented. The mean weekly working time was 63 h with a daily time range of 10.5 h. In total, 98.1 % of residents worked &gt;48 h by week. In 25 % of cases, residents assumed professional activity after on-call. 57.1 % of French universities offered adjustments to reduce weekly working time consisting of an additional day off for on-call during Friday, Saturday or Sunday.</div></div><div><h3>Conclusion</h3><div>The weekly working time is insufficiently controlled in French ObGyn residents but there are very promising suggestions for improvement.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103033"},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of obstetric outcomes between single and double embryo transfers among singleton live births from vitrified donor oocyte IVF cycles: a cohort study","authors":"Robert B. Hood ,&nbsp;Heather S. Hipp ,&nbsp;Zsolt P. Nagy ,&nbsp;Jessica B. Spencer ,&nbsp;Daniel B. Shapiro ,&nbsp;Audrey J. Gaskins","doi":"10.1016/j.jogoh.2025.103020","DOIUrl":"10.1016/j.jogoh.2025.103020","url":null,"abstract":"<div><h3>Research objective</h3><div>Among singleton live births resulting from donor oocyte cycles, do perinatal outcomes differ between single (SET) and double embryo transfers (DET)?</div></div><div><h3>Methods</h3><div>We utilized a retrospective cohort of 610 recipients who had a singleton livebirth following nonidentified vitrified donor oocyte IVF cycle from a fertility clinic in the southeast US, 2008–2016. Perinatal outcomes included gestational age and birth weight. Preterm birth was defined as &lt;37 weeks and low birth weight was defined as &lt;2500 grams. Cluster weighted generalized estimating equations were used to calculate effect estimates adjusted for year, embryo stage, prior donor transfers, recipient and donor age, recipient and donor body mass index, and infertility diagnosis.</div></div><div><h3>Results</h3><div>Among the 698 singleton live births, 482 (69 %) were the result of a SET while 216 (31 %) were the result of a DET. Women who had two embryos transferred, as compared with one, did not have a statistically significant difference in gestational age (adjusted mean difference [AMD]:0.23 weeks, 95 % confidence interval [CI]:0.63, 0.17) or birth weight (AMD:27.9 grams, 95 % CI:137.7, 81.9). Similar, non-significant results were observed when evaluating risk of preterm birth and low birthweight.</div></div><div><h3>Conclusion</h3><div>We did not observe an adverse impact of DET on gestational age or birthweight compared to SET in singleton live births from donor cycles. While reassuring, clinicians should continue to use SET in donor oocyte recipients to reduce the adverse impact of multiple pregnancy and all the associated adverse birth outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103020"},"PeriodicalIF":1.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}