Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Commentary on \"Impact of a national public health plan on the time frame for moderate and severe endometriosis diagnosis\".","authors":"Ruihang Luo, Maosen Liu, Wei Zhong, Jian Bo Wu, Yuxin Fan, Mingshan Liu","doi":"10.1016/j.jogoh.2025.103048","DOIUrl":"10.1016/j.jogoh.2025.103048","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":" ","pages":"103048"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of GLP-1 receptor agonists in Obstetrics and Perinatal Outcomes: A Systematic Review and Meta-Analysis.","authors":"Bruna Benigna Sales Armstrong, Ana Clara Pimenta Servidoni, Giovanna Cristina de Castro Martin, Guilherme Franceschini Machado, Wellgner Fernandes Oliveira Amador, Abdelrahman Yousif","doi":"10.1016/j.jogoh.2025.103046","DOIUrl":"https://doi.org/10.1016/j.jogoh.2025.103046","url":null,"abstract":"<p><strong>Objective: </strong>Primary endpoint is maternal and fetal complications during pregnancy, labor, and delivery after exposure to GLP-1 receptor agonists.</p><p><strong>Data sources: </strong>A systematic search was conducted across PubMed, Embase, and Cochrane Central databases, including studies published from 2020 to 2025.</p><p><strong>Study eligibility criteria: </strong>Included studies: (1) RCTs or cohorts; (2) exposure to GLP-1 RAs during pregnancy or preconception; (3) control group not exposed to GLP-1 RAs. Excluded studies: (1) without outcomes of interest; (2) lacking data transparency; (3) retracted; (4) abstracts, case reports, reviews; (5) no control group.</p><p><strong>Study appraisal and synthesis methods: </strong>Six studies evaluated GLP-1 RA exposure during preconception or first trimester. Two authors screened studies; a third resolved disagreements. Risk of bias was assessed with ROBINS-I and RoB 2. Meta-analysis pooled continuous outcomes with mean differences and binary outcomes with odds ratios. Heterogeneity was evaluated via Cochrane Q and I². Subgroup analysis focused on first-trimester exposure.</p><p><strong>Results: </strong>No statistically significant differences in pregnancy outcomes between GLP-1 RA and control group, including fetal growth restriction or small for gestational age (p = 0.12), live births (p = 0.10), major birth defects (p = 0.79), miscarriages (p = 0.41), preterm delivery (p = 0.62); and stillbirths (p = 0.09). GLP-1 RAs were linked to a lower risk of congenital heart defects (p = 0.03), even in the subgroup analysis (p = 0.03), and showed no significant protective effect against gestational diabetes (p = 0.49). In subgroup analysis, there were no notable differences in miscarriage (p = 0.32), major birth defects (p = 0.83) and preterm delivery (p = 0.88); there were fewer live births that did not reach statistical significance (p = 0.06).</p><p><strong>Conclusion: </strong>No statistically significant difference was observed between the control and intervention groups. GLP-1 RAs were connected to a lower risk of congenital heart defects.</p>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":" ","pages":"103046"},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with mode of delivery in large-for-gestational-age fetuses: A retrospective cohort study","authors":"Salomé Azeroual,&nbsp;Mohamed Dakin,&nbsp;Théo Joannes,&nbsp;Olivier Graesslin,&nbsp;René Gabriel,&nbsp;Benjamin Birene","doi":"10.1016/j.jogoh.2025.103047","DOIUrl":"10.1016/j.jogoh.2025.103047","url":null,"abstract":"<div><h3>Background</h3><div>Large-for-gestational-age (LGA) fetuses are often associated with increased maternal and neonatal morbidity. Although suspicion of LGA can prompt closer surveillance and interventions such as labor induction, the actual impact on delivery outcomes and complications remains controversial.</div></div><div><h3>Purpose</h3><div>To assess maternal and fetal factors associated with the mode of delivery in pregnancies with LGA fetuses.</div></div><div><h3>Basic procedures</h3><div>Retrospective, single-center study (2018–2021) including term, singleton pregnancies with birthweight ≥ 90th percentile (AUDIPOG). Exclusion criteria were prior cesarean, multiples, preterm birth, non-cephalic presentation, planned cesarean, maternal request, or incomplete records. Primary outcome was mode of delivery. Multiple logistic regression was used.</div></div><div><h3>Main findings</h3><div>A total of 211 women met inclusion criteria. The rate of operative delivery (cesarean or instrumental vaginal birth) was 32.2% (68/211). In multiple logistic regression, nulliparity (OR 8.1, 95% CI 3.2–20.5, <em>p</em> &lt; 0.001), induction of labor (OR 2.6, 95% CI 1.1–6.3, <em>p</em> = 0.035), greater gestational weight gain (OR 1.07 per kg, 95% CI 1.01–1.14, <em>p</em> = 0.021), and prenatal suspicion of macrosomia (EFW &gt; 90th percentile at growth or third-trimester ultrasound, OR 2.9, 95% CI 1.2–7.1, <em>p</em> = 0.019) were independently associated with an increased risk of non-spontaneous birth. Maternal age, diabetes, and a history of LGA were not significantly associated after adjustment. Neonatal outcomes were favorable, with only one case of umbilical arterial pH &lt; 7.00 (0.5%) and no severe traumatic complications.</div></div><div><h3>Conclusions</h3><div>In LGA pregnancies, nulliparity and suspected macrosomia were associated with higher rates of medical intervention, whereas induction and prior vaginal delivery favored spontaneous birth. Neonatal weight did not differ between delivery modes. These findings underscore the complexity of managing suspected LGA fetuses and the need for prospective multicenter studies to refine risk stratification.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103047"},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favorable pregnancy outcome in a woman with extensive disseminated peritoneal leiomyomatosis","authors":"E. Hagelauer ,&nbsp;M. Beck ,&nbsp;C. Rousset-Jablonski ,&nbsp;E. Ruaux ,&nbsp;A. Trecourt ,&nbsp;P. Rousset ,&nbsp;W. Gertych","doi":"10.1016/j.jogoh.2025.103045","DOIUrl":"10.1016/j.jogoh.2025.103045","url":null,"abstract":"<div><div>Disseminated peritoneal leiomyomatosis (DPL) is a rare and benign condition characterized by the progression of smooth muscle tumors across the peritoneal cavity. The etiology is not well understood and could include previous surgeries and hormonal stimulation. We report on a 39-year-old woman with extensive DPL at the end of her pregnancy. She was diagnosed in the context of amenorrhea and was initially treated by gonadotropin-releasing hormone (GnRH) agonist. During pregnancy, a significant increase in lesion size was observed. The day before the planned cesarean-section (C-section), she presented with severe hypercalcemia, which was probably from a paraneoplastic origin. The patient underwent a planned C-section at 36 weeks and 5 days of gestation by midline sub-umbilical laparotomy, allowing a safe delivery.</div><div>This case provides insights for healthcare providers facing similar cases, considering that the obstetrical management of patients with DPL has not yet been defined.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103045"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Follow-Up in young women with severe dysmenorrhea predicts early onset of endometriosis.","authors":"Elvira Nocita, Francesco Giuseppe Martire, Chiara Paladino, Giulia Monaco, Federica Iacobini, Sara Valeriani, Giorgia Soreca, Consuelo Russo, Caterina Exacoustos","doi":"10.1016/j.jogoh.2025.103003","DOIUrl":"10.1016/j.jogoh.2025.103003","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the progression of endometriosis and painful symptoms in young women (≤ 25 years) with severe dysmenorrhea (Visual Analogue Scale score ≥ 7), with or without ultrasound-detected endometriosis, over a follow-up period of 12 to 36 months. The impact of hormone therapy was also assessed.</p><p><strong>Methods: </strong>This retrospective observational study included 124 young women with severe dysmenorrhea: 67 had ultrasound signs of endometriosis/adenomyosis, 57 did not. All patients with ultrasound-detected endometriosis/adenomyosis received continuous hormone therapy, inducing amenorrhea; those without ultrasound findings underwent either cyclic hormone therapy or no treatment. Clinical and ultrasound assessments were performed at baseline and at follow-up visits at 12, 24 and 36 months, recording all symptoms and disease sites.</p><p><strong>Results: </strong>In patients with ultrasound-detected endometriosis on continuous hormone therapy, all painful symptoms improved, and endometrioma size significantly decreased, with 40 % resolving completely. Utero-sacral ligament lesions also shrank, while rectal endometriosis remained unchanged. Ultrasound direct signs of adenomyosis were no longer visible in 22 % of cases. In patients without initial ultrasound evidence of endometriosis and with a regular menstrual cycle, new ultrasound-detected endometriosis emerged in 20 % of cases at follow-up.</p><p><strong>Conclusions: </strong>In young patients with severe dysmenorrhea, clinical and ultrasound follow-up supports early detection of endometriosis and an appropriate treatment may reduce symptoms and prevent disease progression.</p>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":" ","pages":"103003"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What changes in the fetal heart rate are associated with neonatal acidosis during the second stage of labor?","authors":"G. Dhenin ,&nbsp;S. Godin ,&nbsp;N. Ramdane ,&nbsp;H. Behal ,&nbsp;C. Garabedian","doi":"10.1016/j.jogoh.2025.103043","DOIUrl":"10.1016/j.jogoh.2025.103043","url":null,"abstract":"<div><h3>Objective</h3><div>To describe fetal heart rate (FHR) patterns associated with neonatal acidosis during the second stage of labor.</div></div><div><h3>Method</h3><div>This single-center (Lille, France) retrospective cohort study was conducted between September 2022 and January 2023. Fetal heart rate (FHR) during maternal expulsive efforts was interpreted for all low-risk women who delivered vaginally after 37 weeks' gestation. Low risk was defined by the absence of any maternal history, obstetric complications, and a normal fetal heart rate in the hour before the onset of expulsive efforts. A baseline increase was defined as a greater than 20 % increase in baseline FHR. Reduced variability and marked variability were defined as a variability &lt;5 bpm and greater than 25 bpm, respectively. FHRs were also described according to Melchior's classification. Neonatal acidosis was defined as umbilical artery pH &lt;7.15.</div></div><div><h3>Results</h3><div>Among the 275 expulsion FHRs analysed, 7.3 % (20/275) showed increased baseline and 5.5 % (15/275) abnormal variability. Neonatal acidosis occurred in 19.6 % (54/275) of neonates. Increased baseline and bradycardia were significantly associated with neonatal acidosis (14.8 % vs 5.4 %, <em>p</em> = 0.035 and 20.4 % vs 10.0 %, <em>p</em> = 0.035, respectively).</div></div><div><h3>Conclusion</h3><div>Increased baseline fetal heart rate during the second stage of labor was associated with a significant risk of neonatal acidosis. It would be interesting to include it in classifications related to this stage.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103043"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hyperhomocysteinemia with IVF live birth rate: A retrospective cohort study","authors":"Lijun Shui ,&nbsp;Xiaozhu Chen ,&nbsp;Xianchao Dou ,&nbsp;Liangyi Ni ,&nbsp;Chao Chen ,&nbsp;Xinyi Zhu ,&nbsp;Qi Jin ,&nbsp;Shun Bai ,&nbsp;Limin Wu ,&nbsp;Meihong Hu","doi":"10.1016/j.jogoh.2025.103044","DOIUrl":"10.1016/j.jogoh.2025.103044","url":null,"abstract":"<div><h3>Objective</h3><div>Homocysteine (Hcy) has been reported to be associated with female reproduction. However, the correlation between hyperhomocysteinemia (HHcy) and pregnancy outcomes among infertile women remains unclear. This observational study aims to evaluate the effect of HHcy on pregnancy outcomes in infertile patients undergoing ART treatment.</div></div><div><h3>Methods</h3><div>Data were collected from 385 patients (50 in the HHcy group and 335 in the non-HHcy group) who underwent In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) at the First Affiliated Hospital of University of Science and Technology of China. Clinical outcomes between the two groups were analyzed.</div></div><div><h3>Results</h3><div>The number of oocytes retrieved, MII oocytes, oocyte maturation rate and normal fertilization rate did not differ significantly between the two groups. However, the HHcy group exhibited significantly lower rates of biochemical pregnancy (48 % vs. 74.9 %), clinical pregnancy (38 % vs. 63.9 %) and live births (34 % vs. 52.8 %) in the HHcy group compared to non-HHcy group. Logistic regression analyses indicated that HHcy was negatively associated with biochemical pregnancy rate (OR= 0.28, 95 % CI: 0.14–0.54, <em>P</em> &lt; 0.001), clinical pregnancy rate (OR = 0.32, 95 % CI: 0.16–0.61, <em>P</em> &lt; 0.001) and live birth rate (OR = 0.45, 95 % CI: 0.23–0.86, <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>HHcy exhibited a negative correlation with live birth among patients underwent IVF/ICSI. Clinicians should consider focusing more attention on patients with HHcy to enhance ART outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103044"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing outcomes of ovarian cystectomy by vaginal natural orifice transluminal endoscopic surgery versus laparoendoscopic single-site surgery: A systematic review and meta-analysis","authors":"Zainah Abdulbari Mohammed Alhebshi ,&nbsp;Marwah Nasir Ahmad ,&nbsp;Husna Irfan Thalib ,&nbsp;Ayah Nabil Al Jehani ,&nbsp;Amal Mahmoud ,&nbsp;Retaj Jameel Tallab ,&nbsp;Rasil Fayez A. Alahmadi ,&nbsp;Alanood Abdullah Banafea ,&nbsp;Saeed Baradwan","doi":"10.1016/j.jogoh.2025.103041","DOIUrl":"10.1016/j.jogoh.2025.103041","url":null,"abstract":"<div><h3>Background</h3><div>Vaginal natural orifice transluminal endoscopic surgery (vNOTES) and laparoendoscopic single-site surgery (LESS) are minimally invasive approaches for ovarian cystectomy, yet their comparative safety, efficacy, and patient-centered outcomes remain insufficiently evaluated, necessitating this systematic review and meta-analysis.</div></div><div><h3>Materials and Methods</h3><div>In December 2024, we conducted a systematic search using PubMed, Ovid Medline, and Ovid Cochrane. The Methodological Index for Non-Randomized Studies (MINORS) and the Revised Cochrane Risk of Bias (RoB 2) tools have been used for the risk of bias assessment.</div></div><div><h3>Results</h3><div>From an initial 588 records, four studies (576 patients: 197 vNOTES, 379 LESS) were included. Meta-analysis revealed that vNOTES significantly reduced operative time (pooled mean difference (MD) -13.62 min, <em>P</em> = 0.02) and hospital stay (MD -0.44 days, <em>P</em> = 0.03) compared to LESS, with sensitivity analyses strengthening these findings (e.g., MD -18.23 min and -0.63 days post-exclusion). Postoperative pain scores (by visual analogue score (VAS)) were markedly lower for vNOTES (MD -1.09, <em>P</em> &lt; 0.00001), and time to flatus recovery was shorter (MD -3.72 h, <em>P</em> &lt; 0.00001). No significant differences were observed in intraoperative blood loss (MD -6.99 mL, <em>P</em> = 0.27), conversion rates (odds ratio (OR) 1.15, <em>P</em> = 0.91), or overall adverse events (OR 0.70, <em>P</em> = 0.41), though heterogeneity persisted in retrospective subgroup analyses (I² = 72–96 % for operative time, and pain scores).</div></div><div><h3>Conclusion</h3><div>These findings position vNOTES as a favorable option for ovarian cystectomy, offering improved efficacy with safety comparable to LESS; however, further RCTs are needed to strengthen these conclusions.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103041"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Efficacy of non-pharmacological therapies in chronic pelvic pain of endometriosis: A systematic review and meta-analysis”","authors":"Dinesh Puri ,&nbsp;Nivedita Nikhil Desai ,&nbsp;Shubham Kumar","doi":"10.1016/j.jogoh.2025.103040","DOIUrl":"10.1016/j.jogoh.2025.103040","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103040"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips and tricks: How to control bleeding in mini invasive myomectomy?","authors":"Mathilde Castel ,&nbsp;Gaby Moawad ,&nbsp;Malik Boukerrou ,&nbsp;Phuong Lien Tran","doi":"10.1016/j.jogoh.2025.103042","DOIUrl":"10.1016/j.jogoh.2025.103042","url":null,"abstract":"<div><div>Myomectomy using laparoscopic approach offers patients reduced abdominal scars, better post surgical rehabilitation. However, bleeding control may pose a challenge in spite of techniques already described [<span><span>1</span></span>,<span><span>2</span></span>]. Our objective is to show a reproducible technique of bleeding control during mini invasive myomectomy.</div><div>We performed a mini-invasive myomectomy using with robotic surgery, with Da Vinci, X. We describe the case of a 35 year-old women, gesta 0 para 0, who presented with menorrhagia, avec pelvic pain, because of a fibroma FIGO 2–5 of 8 cm. She had a desire of pregnancy. We show tips and tricks to control bleeding: (a) two ways of accessing to uterine artery for its occlusion, using either a vascular clamp or a metallic clip; (b) sub serous infiltration with 20 mL of xylocaine with 1% adrenalin, diluated in 100 mL of NaCl serum using a oocyte punction needle; (c) suture with barbed suture. Blood loss was &lt;200 mL.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103042"},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}