Favorable pregnancy outcome in a woman with extensive disseminated peritoneal leiomyomatosis

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of gynecology obstetrics and human reproduction Pub Date : 2025-10-03 DOI:10.1016/j.jogoh.2025.103045

E. Hagelauer , M. Beck , C. Rousset-Jablonski , E. Ruaux , A. Trecourt , P. Rousset , W. Gertych

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Abstract

Disseminated peritoneal leiomyomatosis (DPL) is a rare and benign condition characterized by the progression of smooth muscle tumors across the peritoneal cavity. The etiology is not well understood and could include previous surgeries and hormonal stimulation. We report on a 39-year-old woman with extensive DPL at the end of her pregnancy. She was diagnosed in the context of amenorrhea and was initially treated by gonadotropin-releasing hormone (GnRH) agonist. During pregnancy, a significant increase in lesion size was observed. The day before the planned cesarean-section (C-section), she presented with severe hypercalcemia, which was probably from a paraneoplastic origin. The patient underwent a planned C-section at 36 weeks and 5 days of gestation by midline sub-umbilical laparotomy, allowing a safe delivery.

This case provides insights for healthcare providers facing similar cases, considering that the obstetrical management of patients with DPL has not yet been defined.

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广泛播散性腹膜平滑肌瘤病患者妊娠结局良好。

播散性腹膜平滑肌瘤病（DPL）是一种罕见的良性疾病，其特征是平滑肌肿瘤在腹膜腔内的进展。病因尚不清楚，可能包括以前的手术和激素刺激。我们报告了一位39岁的女性，在她怀孕结束时患有广泛的DPL。她被诊断为闭经，最初使用促性腺激素释放激素（GnRH）激动剂治疗。在怀孕期间，观察到病变大小明显增加。在计划剖腹产的前一天，她出现了严重的高钙血症，可能是由副肿瘤引起的。患者在妊娠36周零5天通过脐下中线剖腹手术计划剖腹产，允许安全分娩。考虑到DPL患者的产科管理尚未明确，本病例为面临类似病例的医疗保健提供者提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.