Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Comparison of obstetric outcomes between single and double embryo transfers among singleton live births from vitrified donor oocyte IVF cycles: a cohort study","authors":"Robert B. Hood ,&nbsp;Heather S. Hipp ,&nbsp;Zsolt P. Nagy ,&nbsp;Jessica B. Spencer ,&nbsp;Daniel B. Shapiro ,&nbsp;Audrey J. Gaskins","doi":"10.1016/j.jogoh.2025.103020","DOIUrl":"10.1016/j.jogoh.2025.103020","url":null,"abstract":"<div><h3>Research objective</h3><div>Among singleton live births resulting from donor oocyte cycles, do perinatal outcomes differ between single (SET) and double embryo transfers (DET)?</div></div><div><h3>Methods</h3><div>We utilized a retrospective cohort of 610 recipients who had a singleton livebirth following nonidentified vitrified donor oocyte IVF cycle from a fertility clinic in the southeast US, 2008–2016. Perinatal outcomes included gestational age and birth weight. Preterm birth was defined as &lt;37 weeks and low birth weight was defined as &lt;2500 grams. Cluster weighted generalized estimating equations were used to calculate effect estimates adjusted for year, embryo stage, prior donor transfers, recipient and donor age, recipient and donor body mass index, and infertility diagnosis.</div></div><div><h3>Results</h3><div>Among the 698 singleton live births, 482 (69 %) were the result of a SET while 216 (31 %) were the result of a DET. Women who had two embryos transferred, as compared with one, did not have a statistically significant difference in gestational age (adjusted mean difference [AMD]:0.23 weeks, 95 % confidence interval [CI]:0.63, 0.17) or birth weight (AMD:27.9 grams, 95 % CI:137.7, 81.9). Similar, non-significant results were observed when evaluating risk of preterm birth and low birthweight.</div></div><div><h3>Conclusion</h3><div>We did not observe an adverse impact of DET on gestational age or birthweight compared to SET in singleton live births from donor cycles. While reassuring, clinicians should continue to use SET in donor oocyte recipients to reduce the adverse impact of multiple pregnancy and all the associated adverse birth outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103020"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing outcomes of ovarian cystectomy by vaginal natural orifice transluminal endoscopic surgery versus laparoendoscopic single-site surgery: A systematic review and meta-analysis","authors":"Zainah Abdulbari Mohammed Alhebshi ,&nbsp;Marwah Nasir Ahmad ,&nbsp;Husna Irfan Thalib ,&nbsp;Ayah Nabil Al Jehani ,&nbsp;Amal Mahmoud ,&nbsp;Retaj Jameel Tallab ,&nbsp;Rasil Fayez A. Alahmadi ,&nbsp;Alanood Abdullah Banafea ,&nbsp;Saeed Baradwan","doi":"10.1016/j.jogoh.2025.103041","DOIUrl":"10.1016/j.jogoh.2025.103041","url":null,"abstract":"<div><h3>Background</h3><div>Vaginal natural orifice transluminal endoscopic surgery (vNOTES) and laparoendoscopic single-site surgery (LESS) are minimally invasive approaches for ovarian cystectomy, yet their comparative safety, efficacy, and patient-centered outcomes remain insufficiently evaluated, necessitating this systematic review and meta-analysis.</div></div><div><h3>Materials and Methods</h3><div>In December 2024, we conducted a systematic search using PubMed, Ovid Medline, and Ovid Cochrane. The Methodological Index for Non-Randomized Studies (MINORS) and the Revised Cochrane Risk of Bias (RoB 2) tools have been used for the risk of bias assessment.</div></div><div><h3>Results</h3><div>From an initial 588 records, four studies (576 patients: 197 vNOTES, 379 LESS) were included. Meta-analysis revealed that vNOTES significantly reduced operative time (pooled mean difference (MD) -13.62 min, <em>P</em> = 0.02) and hospital stay (MD -0.44 days, <em>P</em> = 0.03) compared to LESS, with sensitivity analyses strengthening these findings (e.g., MD -18.23 min and -0.63 days post-exclusion). Postoperative pain scores (by visual analogue score (VAS)) were markedly lower for vNOTES (MD -1.09, <em>P</em> &lt; 0.00001), and time to flatus recovery was shorter (MD -3.72 h, <em>P</em> &lt; 0.00001). No significant differences were observed in intraoperative blood loss (MD -6.99 mL, <em>P</em> = 0.27), conversion rates (odds ratio (OR) 1.15, <em>P</em> = 0.91), or overall adverse events (OR 0.70, <em>P</em> = 0.41), though heterogeneity persisted in retrospective subgroup analyses (I² = 72–96 % for operative time, and pain scores).</div></div><div><h3>Conclusion</h3><div>These findings position vNOTES as a favorable option for ovarian cystectomy, offering improved efficacy with safety comparable to LESS; however, further RCTs are needed to strengthen these conclusions.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103041"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of pregnant women complying or not with physical activity recommendations during the second trimester of pregnancy: A French pilot study","authors":"M. Gerard ,&nbsp;R. Beranger ,&nbsp;B. Pereira ,&nbsp;N. Boisseau","doi":"10.1016/j.jogoh.2025.103007","DOIUrl":"10.1016/j.jogoh.2025.103007","url":null,"abstract":"<div><h3>Introduction</h3><div>Insufficient physical activity (PA) during pregnancy is a global public health concern. The aims of this study were: i) to determine retrospectively PA and sedentary time in women in the second trimester of pregnancy, and ii) to identify factors that influence adherence to the French National College of Midwives guidelines on PA (≥150 minutes of moderate to high-intensity PA per week).</div></div><div><h3>Methods</h3><div>This cross-sectional, single-centre study, conducted at the University Hospital of Rennes, included 195 pregnant women. PA levels and sedentary time before and during the second trimester of pregnancy were determined using an anonymous self-report questionnaire. The self-reported PA levels were compared to the guidelines on PA. Bivariate analyses and Poisson generalized linear regression models were used to identify factors associated with non-compliance to such guidelines.</div></div><div><h3>Results</h3><div>Only 30.7 % of pregnant women reported the recommended PA levels in the second trimester of pregnancy. Sedentary time and adherence to the PA guidelines were not associated. Fatigue was the most frequently cited reason for insufficient PA (71.6 %). Preconception PA level was the strongest predictor of adherence. Body mass index &gt;25 kg/m², &lt;2 years of higher education, limited access to transportation and sports facilities, and living in a town with &lt;2.000 inhabitants also were associated with lower PA levels.</div></div><div><h3>Conclusion</h3><div>Adherence to the PA recommendations is low among French pregnant women. Public health initiatives should emphasize PA importance before pregnancy and provide tailored support throughout gestation. Future studies should explore the interplay between PA, sedentary time and pregnancy outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103007"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-pharmacological therapies in chronic pelvic pain of endometriosis: a systematic review and meta-analysis","authors":"Hegila da Silva Dantas ,&nbsp;Maiara Costa de Oliveira ,&nbsp;Tatiana CLA da Silva ,&nbsp;Joyce MP de Oliveira ,&nbsp;Maria LAS de Carvalho ,&nbsp;Maria TABC Micussi","doi":"10.1016/j.jogoh.2025.103006","DOIUrl":"10.1016/j.jogoh.2025.103006","url":null,"abstract":"<div><h3>Introduction</h3><div>Endometriosis is a condition that manifests through chronic pelvic pain and infertility. Current therapeutic options do not provide complete relief and may result in undesirable side effects.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of non-pharmacological therapies in relieving chronic pelvic pain compared to placebo therapies in women with endometriosis.</div></div><div><h3>Methods</h3><div>Developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered in Prospero (CRD42023455704). The searches were conducted in the Web of Science, PubMed, Scielo, Embase, and Pedro databases. We included clinical trials that employed non-pharmacological therapies and evaluated chronic pelvic pain as the primary outcome. The risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to evaluate the quality of the evidence.</div></div><div><h3>Results</h3><div>Nine studies were included. All studies addressed pain. The intervention group showed greater efficacy in reducing pain compared to the control group, except in one study. Five studies presented a high risk of bias, while four showed a low risk of bias. The meta-analysis for the pain outcome was conducted with five articles. The intervention was superior to the control, effectively reducing pain, with a mean difference of –1.40; 95 % CI –1.71, –1.09.</div></div><div><h3>Conclusion</h3><div>The studies showed improvements in pain relief and quality of through non-pharmacological therapies. However, evidence confidence was very low. This highlights the need for more rigorous studies to confirm the efficacy of non-pharmacological interventions in reducing pain in endometriosis.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103006"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a National Public Health Plan on the time frame for moderate and severe endometriosis diagnosis","authors":"Emilie Gastineau ,&nbsp;Laura Miquel ,&nbsp;Antoine Netter ,&nbsp;Aubert Agostini ,&nbsp;Maeva Jego ,&nbsp;Blandine Courbiere","doi":"10.1016/j.jogoh.2025.103011","DOIUrl":"10.1016/j.jogoh.2025.103011","url":null,"abstract":"<div><h3>Objective</h3><div>to study the time from symptom onset to the diagnosis of moderate and severe endometriosis and to compare this delay before and after the implementation of the French National Endometriosis Public Health Plan.</div></div><div><h3>Design</h3><div>Monocentric retrospective cohort study.</div></div><div><h3>Exposure</h3><div>A comparison of diagnostic delays for moderate and severe endometriosis in women before and after the implementation of a National Public Health Plan in February 2022.</div></div><div><h3>Main outcome measures</h3><div>Diagnostic delay, defined as the time from symptom onset to a final diagnosis of moderate or severe endometriosis confirmed by imaging or surgery.</div></div><div><h3>Results</h3><div>The median diagnostic delay was 5.0 years (range 1.6–11.2) with no statistically significant difference observed before and after the implementation of the National Endometriosis Public Health Plan: median delay of 5.7 years (range 1.6–11.8) <em>Vs.</em> 4.2 years (range 1.5–11.1) (<em>P</em> = 0.70). The most common presenting symptom was dysmenorrhea (73 %), and 91 women (65 %) experienced primary infertility. Women whose initial symptom was infertility had a significantly shorter diagnostic delay compared to those with pain symptoms: median (IQR) of 1.5 (0.9–3.1) <em>Vs.</em> 6.9 (2.1–12.6) years, <em>P</em> ≤ 0.001. A younger age at symptom onset was associated with a longer diagnostic delay.</div></div><div><h3>Conclusion</h3><div>Despite increased awareness efforts by Public Health institutions, significant diagnostic delays for moderate and severe endometriosis persist, particularly among younger women. The objective of the National Endometriosis Public Health Plan was to raise awareness among healthcare providers to reduce diagnostic delays; however, further longitudinal studies are needed to confirm its long-term impact.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103011"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “The value of ultrasound guidance during IUD insertion in women with RVF uterus: A randomized controlled trial” [J Gynecol Obstet Hum Reprod 50 (2025) 101875]","authors":"Ahmed M. Maged,&nbsp;Adel M. Nada,&nbsp;Hala Abdelwahab,&nbsp;Emad Salah,&nbsp;Mahmoud Soliman,&nbsp;Eman A. Hussein,&nbsp;Aimy Essam,&nbsp;Hala Nabil","doi":"10.1016/j.jogoh.2025.103016","DOIUrl":"10.1016/j.jogoh.2025.103016","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103016"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential and mechanism of mesenchymal stem cells in the treatment of premature ovarian failure","authors":"Wei-Ran Jin ,&nbsp;Shu-Yang He ,&nbsp;Xian-Xian Mao ,&nbsp;Jing-Yuan Li ,&nbsp;Xiang-Cheng Zhang ,&nbsp;Quan-Wen Liu","doi":"10.1016/j.jogoh.2025.103031","DOIUrl":"10.1016/j.jogoh.2025.103031","url":null,"abstract":"<div><div>Premature ovarian failure (POF), a common endocrine disorder, pertains to the loss of ovarian function in women under the age of 40 years. It is clinically characterized by estrogen deficiency with increased gonadotropin level and amenorrhea, which can lead to loss of fertility and increase the risk of other diseases, including cardiovascular disorders, osteoporosis, and mood disorders. Currently, the most common treatment is hormone replacement therapy (HRT), it relieves menopausal symptoms but does not improve the function of the ovary. Mesenchymal stem cells (MSCs) share the ability of self-renewal and differentiation, playing an important role in the regeneration of injured tissues. Notably, accumulating evidence indicates that MSCs primarily exert their effects through paracrine interactions with the ovarian cortex, rather than contributing to de novo oocyte generation. This suggests that ovarian exhaustion is not complete in POF, leaving a residual ovarian environment that allows MSCs to act. So far, many reports have demonstrated that transplantation of MSCs can improve ovarian structure and function, promote follicular development, and restore hormone levels by anti-apoptosis, promoting angiogenesis, immunomodulation, and anti-oxidation, suggesting the potential of MSCs as alternative therapeutics for POF. Therefore, this study aims to summarize the latest findings on the mechanism and application of MSCs in POF treatment, providing directions for continued research and clinical therapy.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103031"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New challenges in operative vaginal delivery: the Odon device. A systematic review","authors":"Mattia Dominoni ,&nbsp;Gabriele Rasore ,&nbsp;Martina Rita Pano ,&nbsp;Alessia Scimeca ,&nbsp;Barbara Gardella","doi":"10.1016/j.jogoh.2025.103017","DOIUrl":"10.1016/j.jogoh.2025.103017","url":null,"abstract":"<div><div>Operative vaginal delivery is the best option for accelerating labor in the second stage labor; however, this technique requires precise clinical assessment, customized care, skilled and appropriately educated workers, in order to avoid both maternal and fetal complications. The aim of this systematic review is to analyze the innovation, design, and effectiveness of a new instrument for Operative Vaginal Delivery, the Odon device, in order to improve intrapartum obstetric care in clinical practice, to facilitate the instrumental vaginal birth, and increase maternal and neonatal outcomes.</div><div>A literature search was conducted thought electronic databases PubMed, EMBASE, Web Of Science. We considered papers published online from 2000 until January 2025, reporting the use of Odon device for operative vaginal delivery. The research was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. Two reviewers independently screened the abstracts of the selected studies and extracted data from full-text articles. The data were subsequently tabulated and evaluated. We selected 14 studies suitable for this systematic review.</div><div>The operative vaginal birth is expedited with the Odon Device, which reported a safe, feasible and effective profile, both for structural characteristics and clinical application. There are no serious maternal and neonatal adverse events related to the use of the device during birth. There are no serious adverse device effects. The operators reported elevated value of satisfaction about the use and application of this new instrument. A favorable evaluation and positive experience were reported also by pregnant women and obstetrics. In conclusion, phase I and II trials show that the Odon device has satisfactory safety, feasibility, and efficacy profile, so it may be considered for potential clinical uses in addition to existing procedures for operative vaginal delivery. Randomized clinical studies are required to clarify the potentials benefits associated with the use of the Odon device on newborns in comparison to other instruments for OVD.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103017"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Comparison of the four malignancy risk indices in the discrimination of malignant ovarian masses: A cross-sectional study” [J Gynecol Obstet Hum Reprod 50 (2025) 101986]","authors":"Mustafa N. Ali,&nbsp;Dina Habib,&nbsp;Ahmed I. Hassanien,&nbsp;Ahmed M. Abbas","doi":"10.1016/j.jogoh.2025.103021","DOIUrl":"10.1016/j.jogoh.2025.103021","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103021"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging education: Boosting HPV vaccination through a serious game","authors":"Pauline Ferreira ,&nbsp;Julie Duclaud ,&nbsp;Romane Tarrusson ,&nbsp;Emmanuel Chirpaz ,&nbsp;Antoine Bertolotti ,&nbsp;Vincent Balaya ,&nbsp;Phuong Lien Tran","doi":"10.1016/j.jogoh.2025.103005","DOIUrl":"10.1016/j.jogoh.2025.103005","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103005"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}