Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Prevalence of polycystic ovarian syndrome in South Asian countries and 21 global regions with Sociodemographic index: A systematic analysis of the Global Burden of Disease (1990–2021)","authors":"Prakasini Satapathy ,&nbsp;Nasir Vadia ,&nbsp;Soumya V Menon ,&nbsp;Kattela Chennakesavulu ,&nbsp;Rajashree Panigrahi ,&nbsp;Ganesh Bushi ,&nbsp;Mahendra Singh ,&nbsp;Sanjit Sah ,&nbsp;Awakash Turkar ,&nbsp;S． Govinda Rao ,&nbsp;Muhammed Shabil ,&nbsp;Manya Soni","doi":"10.1016/j.jogoh.2025.103019","DOIUrl":"10.1016/j.jogoh.2025.103019","url":null,"abstract":"<div><h3>Background</h3><div>This analysis examines both the prevalence and the disability-adjusted life years (DALYs) linked to polycystic ovary syndrome (PCOS) across South Asia and worldwide, drawing on data from the Global Burden of Disease (GBD) 1990–2021 study.</div></div><div><h3>Methods</h3><div>Data from GBD 2021 were analyzed using Joinpoint Regression to assess age-standardized prevalence rates (ASPR) and DALYs (ASDR). Sociodemographic index (SDI) was incorporated to evaluate the relationship between socioeconomic factors and PCOS burden. The analysis was conducted across 21 global regions, with Pearson's correlation assessing the association between SDI and PCOS outcomes.</div></div><div><h3>Results</h3><div>The prevalence of PCOS in South Asia increased significantly, with an average annual percentage change (AAPC) of 1.87 % (95 % CI: 1.85–1.88) from 1990 to 2021. India had the highest prevalence in 2021 (269.8 per 100,000), and the highest total percentage change (TPC) in prevalence (86.9 %). DALYs rate in India were similarly high (11.1 per 100,000. A positive correlation (<em>r</em> = 0.57, <em>p</em> &lt; 0.001) between SDI and both prevalence and DALYs was observed.</div></div><div><h3>Conclusion</h3><div>PCOS prevalence and DALYs are rising across South Asia, with India experiencing the highest burden. Public health interventions should focus on improving awareness, diagnosis, and management, especially in lower SDI regions to mitigate the growing health challenge.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103019"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does a second cervical ripening procedure improve vaginal delivery outcomes in primiparous women with an unfavourable Cervix? A before-and-after French study","authors":"Mathilde Frere ,&nbsp;Clemence Klapczynski ,&nbsp;Eric Verspyck ,&nbsp;Sophia Braund","doi":"10.1016/j.jogoh.2025.103008","DOIUrl":"10.1016/j.jogoh.2025.103008","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effectiveness of a second cervical ripening procedure in primiparous women with an unfavourable persistent cervix.</div></div><div><h3>Methods</h3><div>This retrospective, before-and-after, comparative study was conducted at Rouen University Hospital, France between January 1st, 2018, and August 15th, 2022. Inclusion criteria were women with indications for labour induction with singleton term pregnancies in cephalic presentation and with a Bishop score &lt;6 who required an initial cervical ripening. All women underwent an initial cervical ripening procedure with either a balloon catheter or vaginal dinoprostone. In the before-protocol group, labour induction was mostly pursued with oxytocin regardless of cervical status. In the after-protocol group (post-November 2020), a second cervical ripening procedure was proposed if the Bishop score remained ≤ 4. The primary outcome was caesarean section rate. A sensitivity analysis was also performed in women with a Bishop score &lt;6 after the first ripening.</div></div><div><h3>Results</h3><div>A total of 384 women were included in the study and were then divided in the before- protocol group (n=184) or in the after-protocol group (n=200). The caesarean section rate significantly decreased in the after-protocol group (31 % vs. 40.8 %; p=0.04). Bishop scores before oxytocin administration were significantly higher in the after-protocol group (median: 6 vs. 5; p=0.01). After adjustment, no significant association was found between the use of the new protocol and the caesarean section risk (OR 0.82; 95 % CI [0.58–1.34]). Factors independently associated with caesarean delivery were advanced maternal age, women not born in France, and lower Bishop scores both before and after cervical ripening. In the subgroup of women with persistent unfavourable cervix, the second procedure improved Bishop scores but was not associated with a significant reduction in caesarean section rate.</div></div><div><h3>Conclusion</h3><div>A second cervical ripening procedure for women with persistent low Bishop scores was not significantly associated with reduced caesarean section rates. Further studies are needed to evaluate whether combining cervical ripening methods can enhance vaginal delivery rates.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103008"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullying and burnout in French obstetrics and gynecology residency programs: a national cross-sectional study","authors":"Chloé Gaillard ,&nbsp;Camille Durand ,&nbsp;Marie Allegrini ,&nbsp;Estelle Le Pabic ,&nbsp;Estelle Michinov ,&nbsp;Ludivine Dion ,&nbsp;Vincent Lavoué ,&nbsp;Jean Levêque ,&nbsp;Linda Lassel ,&nbsp;Maela Le Lous ,&nbsp;Krystel Nyangoh Timoh","doi":"10.1016/j.jogoh.2025.103034","DOIUrl":"10.1016/j.jogoh.2025.103034","url":null,"abstract":"<div><h3>Introduction</h3><div>Prior research has demonstrated high burnout rates during medical residency, namely among obstetrics and gynecology (Ob-Gyn) specialists. Concurrently, reports of workplace bullying, particularly in surgical wards, have risen. However, no studies have evaluated these aspects among French Ob-Gyn residents. This study assessed the prevalence and impact of workplace bullying on Ob-Gyn residents, the relationship between bullying and burnout, and the risk and protective factors influencing burnout.</div></div><div><h3>Methods</h3><div>A national, observational, cross-sectional study was conducted involving 37 French Ob-Gyn residency programs during the 2021–2022 academic year. Data were collected via an anonymous online survey using instruments such as the Maslach Burnout Inventory, Negative Acts Questionnaire-Revised (NAQ-R), and Hospital Anxiety and Depression Scale. Sociodemographic data, working conditions, sources/locations of bullying, and incidence of suicidal ideation were also collected. Multivariable logistic regression was used to analyze associations.</div></div><div><h3>Results</h3><div>Of 625 respondents, 52.4% reported bullying as measured by the NAQ-R. Burnout was present in 18.4%, with notable rates of professional exhaustion (24.3%), depersonalization (34.9%), and diminished personal accomplishment (25.1%). A significative correlation between workplace bullying and burnout was found. Strong social support from superiors emerged as protective against burnout, whereas frequent exposure to bullying, excessive working hours, and high stress levels were identified as major risk factors.</div></div><div><h3>Conclusion</h3><div>Our study reveals that 52.5% of responding residents reported experiencing workplace bullying, and 18.4% met the criteria for burnout. While these findings are concerning and warrant attention, they reflect the experiences of residents who chose to participate in the survey, and may therefore overrepresent those most affected. Nevertheless, the significant association observed between bullying and burnout highlights the need for institutional strategies to better support residents' well-being and ensure a safe, respectful working environment in obstetrics and gynecology residency programs.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103034"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of obstetric outcomes between single and double embryo transfers among singleton live births from vitrified donor oocyte IVF cycles: a cohort study","authors":"Robert B. Hood ,&nbsp;Heather S. Hipp ,&nbsp;Zsolt P. Nagy ,&nbsp;Jessica B. Spencer ,&nbsp;Daniel B. Shapiro ,&nbsp;Audrey J. Gaskins","doi":"10.1016/j.jogoh.2025.103020","DOIUrl":"10.1016/j.jogoh.2025.103020","url":null,"abstract":"<div><h3>Research objective</h3><div>Among singleton live births resulting from donor oocyte cycles, do perinatal outcomes differ between single (SET) and double embryo transfers (DET)?</div></div><div><h3>Methods</h3><div>We utilized a retrospective cohort of 610 recipients who had a singleton livebirth following nonidentified vitrified donor oocyte IVF cycle from a fertility clinic in the southeast US, 2008–2016. Perinatal outcomes included gestational age and birth weight. Preterm birth was defined as &lt;37 weeks and low birth weight was defined as &lt;2500 grams. Cluster weighted generalized estimating equations were used to calculate effect estimates adjusted for year, embryo stage, prior donor transfers, recipient and donor age, recipient and donor body mass index, and infertility diagnosis.</div></div><div><h3>Results</h3><div>Among the 698 singleton live births, 482 (69 %) were the result of a SET while 216 (31 %) were the result of a DET. Women who had two embryos transferred, as compared with one, did not have a statistically significant difference in gestational age (adjusted mean difference [AMD]:0.23 weeks, 95 % confidence interval [CI]:0.63, 0.17) or birth weight (AMD:27.9 grams, 95 % CI:137.7, 81.9). Similar, non-significant results were observed when evaluating risk of preterm birth and low birthweight.</div></div><div><h3>Conclusion</h3><div>We did not observe an adverse impact of DET on gestational age or birthweight compared to SET in singleton live births from donor cycles. While reassuring, clinicians should continue to use SET in donor oocyte recipients to reduce the adverse impact of multiple pregnancy and all the associated adverse birth outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103020"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing outcomes of ovarian cystectomy by vaginal natural orifice transluminal endoscopic surgery versus laparoendoscopic single-site surgery: A systematic review and meta-analysis","authors":"Zainah Abdulbari Mohammed Alhebshi ,&nbsp;Marwah Nasir Ahmad ,&nbsp;Husna Irfan Thalib ,&nbsp;Ayah Nabil Al Jehani ,&nbsp;Amal Mahmoud ,&nbsp;Retaj Jameel Tallab ,&nbsp;Rasil Fayez A. Alahmadi ,&nbsp;Alanood Abdullah Banafea ,&nbsp;Saeed Baradwan","doi":"10.1016/j.jogoh.2025.103041","DOIUrl":"10.1016/j.jogoh.2025.103041","url":null,"abstract":"<div><h3>Background</h3><div>Vaginal natural orifice transluminal endoscopic surgery (vNOTES) and laparoendoscopic single-site surgery (LESS) are minimally invasive approaches for ovarian cystectomy, yet their comparative safety, efficacy, and patient-centered outcomes remain insufficiently evaluated, necessitating this systematic review and meta-analysis.</div></div><div><h3>Materials and Methods</h3><div>In December 2024, we conducted a systematic search using PubMed, Ovid Medline, and Ovid Cochrane. The Methodological Index for Non-Randomized Studies (MINORS) and the Revised Cochrane Risk of Bias (RoB 2) tools have been used for the risk of bias assessment.</div></div><div><h3>Results</h3><div>From an initial 588 records, four studies (576 patients: 197 vNOTES, 379 LESS) were included. Meta-analysis revealed that vNOTES significantly reduced operative time (pooled mean difference (MD) -13.62 min, <em>P</em> = 0.02) and hospital stay (MD -0.44 days, <em>P</em> = 0.03) compared to LESS, with sensitivity analyses strengthening these findings (e.g., MD -18.23 min and -0.63 days post-exclusion). Postoperative pain scores (by visual analogue score (VAS)) were markedly lower for vNOTES (MD -1.09, <em>P</em> &lt; 0.00001), and time to flatus recovery was shorter (MD -3.72 h, <em>P</em> &lt; 0.00001). No significant differences were observed in intraoperative blood loss (MD -6.99 mL, <em>P</em> = 0.27), conversion rates (odds ratio (OR) 1.15, <em>P</em> = 0.91), or overall adverse events (OR 0.70, <em>P</em> = 0.41), though heterogeneity persisted in retrospective subgroup analyses (I² = 72–96 % for operative time, and pain scores).</div></div><div><h3>Conclusion</h3><div>These findings position vNOTES as a favorable option for ovarian cystectomy, offering improved efficacy with safety comparable to LESS; however, further RCTs are needed to strengthen these conclusions.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103041"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of pregnant women complying or not with physical activity recommendations during the second trimester of pregnancy: A French pilot study","authors":"M. Gerard ,&nbsp;R. Beranger ,&nbsp;B. Pereira ,&nbsp;N. Boisseau","doi":"10.1016/j.jogoh.2025.103007","DOIUrl":"10.1016/j.jogoh.2025.103007","url":null,"abstract":"<div><h3>Introduction</h3><div>Insufficient physical activity (PA) during pregnancy is a global public health concern. The aims of this study were: i) to determine retrospectively PA and sedentary time in women in the second trimester of pregnancy, and ii) to identify factors that influence adherence to the French National College of Midwives guidelines on PA (≥150 minutes of moderate to high-intensity PA per week).</div></div><div><h3>Methods</h3><div>This cross-sectional, single-centre study, conducted at the University Hospital of Rennes, included 195 pregnant women. PA levels and sedentary time before and during the second trimester of pregnancy were determined using an anonymous self-report questionnaire. The self-reported PA levels were compared to the guidelines on PA. Bivariate analyses and Poisson generalized linear regression models were used to identify factors associated with non-compliance to such guidelines.</div></div><div><h3>Results</h3><div>Only 30.7 % of pregnant women reported the recommended PA levels in the second trimester of pregnancy. Sedentary time and adherence to the PA guidelines were not associated. Fatigue was the most frequently cited reason for insufficient PA (71.6 %). Preconception PA level was the strongest predictor of adherence. Body mass index &gt;25 kg/m², &lt;2 years of higher education, limited access to transportation and sports facilities, and living in a town with &lt;2.000 inhabitants also were associated with lower PA levels.</div></div><div><h3>Conclusion</h3><div>Adherence to the PA recommendations is low among French pregnant women. Public health initiatives should emphasize PA importance before pregnancy and provide tailored support throughout gestation. Future studies should explore the interplay between PA, sedentary time and pregnancy outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103007"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-pharmacological therapies in chronic pelvic pain of endometriosis: a systematic review and meta-analysis","authors":"Hegila da Silva Dantas ,&nbsp;Maiara Costa de Oliveira ,&nbsp;Tatiana CLA da Silva ,&nbsp;Joyce MP de Oliveira ,&nbsp;Maria LAS de Carvalho ,&nbsp;Maria TABC Micussi","doi":"10.1016/j.jogoh.2025.103006","DOIUrl":"10.1016/j.jogoh.2025.103006","url":null,"abstract":"<div><h3>Introduction</h3><div>Endometriosis is a condition that manifests through chronic pelvic pain and infertility. Current therapeutic options do not provide complete relief and may result in undesirable side effects.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of non-pharmacological therapies in relieving chronic pelvic pain compared to placebo therapies in women with endometriosis.</div></div><div><h3>Methods</h3><div>Developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered in Prospero (CRD42023455704). The searches were conducted in the Web of Science, PubMed, Scielo, Embase, and Pedro databases. We included clinical trials that employed non-pharmacological therapies and evaluated chronic pelvic pain as the primary outcome. The risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to evaluate the quality of the evidence.</div></div><div><h3>Results</h3><div>Nine studies were included. All studies addressed pain. The intervention group showed greater efficacy in reducing pain compared to the control group, except in one study. Five studies presented a high risk of bias, while four showed a low risk of bias. The meta-analysis for the pain outcome was conducted with five articles. The intervention was superior to the control, effectively reducing pain, with a mean difference of –1.40; 95 % CI –1.71, –1.09.</div></div><div><h3>Conclusion</h3><div>The studies showed improvements in pain relief and quality of through non-pharmacological therapies. However, evidence confidence was very low. This highlights the need for more rigorous studies to confirm the efficacy of non-pharmacological interventions in reducing pain in endometriosis.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103006"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a National Public Health Plan on the time frame for moderate and severe endometriosis diagnosis","authors":"Emilie Gastineau ,&nbsp;Laura Miquel ,&nbsp;Antoine Netter ,&nbsp;Aubert Agostini ,&nbsp;Maeva Jego ,&nbsp;Blandine Courbiere","doi":"10.1016/j.jogoh.2025.103011","DOIUrl":"10.1016/j.jogoh.2025.103011","url":null,"abstract":"<div><h3>Objective</h3><div>to study the time from symptom onset to the diagnosis of moderate and severe endometriosis and to compare this delay before and after the implementation of the French National Endometriosis Public Health Plan.</div></div><div><h3>Design</h3><div>Monocentric retrospective cohort study.</div></div><div><h3>Exposure</h3><div>A comparison of diagnostic delays for moderate and severe endometriosis in women before and after the implementation of a National Public Health Plan in February 2022.</div></div><div><h3>Main outcome measures</h3><div>Diagnostic delay, defined as the time from symptom onset to a final diagnosis of moderate or severe endometriosis confirmed by imaging or surgery.</div></div><div><h3>Results</h3><div>The median diagnostic delay was 5.0 years (range 1.6–11.2) with no statistically significant difference observed before and after the implementation of the National Endometriosis Public Health Plan: median delay of 5.7 years (range 1.6–11.8) <em>Vs.</em> 4.2 years (range 1.5–11.1) (<em>P</em> = 0.70). The most common presenting symptom was dysmenorrhea (73 %), and 91 women (65 %) experienced primary infertility. Women whose initial symptom was infertility had a significantly shorter diagnostic delay compared to those with pain symptoms: median (IQR) of 1.5 (0.9–3.1) <em>Vs.</em> 6.9 (2.1–12.6) years, <em>P</em> ≤ 0.001. A younger age at symptom onset was associated with a longer diagnostic delay.</div></div><div><h3>Conclusion</h3><div>Despite increased awareness efforts by Public Health institutions, significant diagnostic delays for moderate and severe endometriosis persist, particularly among younger women. The objective of the National Endometriosis Public Health Plan was to raise awareness among healthcare providers to reduce diagnostic delays; however, further longitudinal studies are needed to confirm its long-term impact.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103011"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “The value of ultrasound guidance during IUD insertion in women with RVF uterus: A randomized controlled trial” [J Gynecol Obstet Hum Reprod 50 (2025) 101875]","authors":"Ahmed M. Maged,&nbsp;Adel M. Nada,&nbsp;Hala Abdelwahab,&nbsp;Emad Salah,&nbsp;Mahmoud Soliman,&nbsp;Eman A. Hussein,&nbsp;Aimy Essam,&nbsp;Hala Nabil","doi":"10.1016/j.jogoh.2025.103016","DOIUrl":"10.1016/j.jogoh.2025.103016","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103016"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential and mechanism of mesenchymal stem cells in the treatment of premature ovarian failure","authors":"Wei-Ran Jin ,&nbsp;Shu-Yang He ,&nbsp;Xian-Xian Mao ,&nbsp;Jing-Yuan Li ,&nbsp;Xiang-Cheng Zhang ,&nbsp;Quan-Wen Liu","doi":"10.1016/j.jogoh.2025.103031","DOIUrl":"10.1016/j.jogoh.2025.103031","url":null,"abstract":"<div><div>Premature ovarian failure (POF), a common endocrine disorder, pertains to the loss of ovarian function in women under the age of 40 years. It is clinically characterized by estrogen deficiency with increased gonadotropin level and amenorrhea, which can lead to loss of fertility and increase the risk of other diseases, including cardiovascular disorders, osteoporosis, and mood disorders. Currently, the most common treatment is hormone replacement therapy (HRT), it relieves menopausal symptoms but does not improve the function of the ovary. Mesenchymal stem cells (MSCs) share the ability of self-renewal and differentiation, playing an important role in the regeneration of injured tissues. Notably, accumulating evidence indicates that MSCs primarily exert their effects through paracrine interactions with the ovarian cortex, rather than contributing to de novo oocyte generation. This suggests that ovarian exhaustion is not complete in POF, leaving a residual ovarian environment that allows MSCs to act. So far, many reports have demonstrated that transplantation of MSCs can improve ovarian structure and function, promote follicular development, and restore hormone levels by anti-apoptosis, promoting angiogenesis, immunomodulation, and anti-oxidation, suggesting the potential of MSCs as alternative therapeutics for POF. Therefore, this study aims to summarize the latest findings on the mechanism and application of MSCs in POF treatment, providing directions for continued research and clinical therapy.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 9","pages":"Article 103031"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}