Evaluation of the M6P model in predicting ectopic pregnancy among pregnancies of unknown location: A prospective monocentric study in Tunisia

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of gynecology obstetrics and human reproduction Pub Date : 2025-09-15 DOI:10.1016/j.jogoh.2025.103035

Wissal Jaafar , Ferdaous Mellouli , Hamdi Dhaouadi , Yasmine Chiba , Malak Medemagh , Mehdi Bouassida , Nahed Khalifa , Mechaal Mourali

{"title":"Evaluation of the M6P model in predicting ectopic pregnancy among pregnancies of unknown location: A prospective monocentric study in Tunisia","authors":"Wissal Jaafar , Ferdaous Mellouli , Hamdi Dhaouadi , Yasmine Chiba , Malak Medemagh , Mehdi Bouassida , Nahed Khalifa , Mechaal Mourali","doi":"10.1016/j.jogoh.2025.103035","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Pregnancy of unknown location (PUL) refers to a positive pregnancy test without definitive ultrasound evidence of intrauterine or ectopic pregnancy. It present a diagnostic challenge in early pregnancy management due to the risk of ectopic pregnancy (EP).</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted on 179 women presenting with PUL. We assessed the predictive accuracy of the M6P model and analyzed its performance compared to standard clinical, biological, and ultrasound parameters among patients with PUL in a Tunisian population.</div></div><div><h3>Results</h3><div>The M6P model showed promising performance in stratifying EP risk factors significantly associated with high-risk EP included history of ectopic pregnancy, intrauterine device use, history of pelvic inflammatory disease, and smoking.</div></div><div><h3>Conclusion</h3><div>The M6P model is a valuable, objective, and reproducible tool for early risk stratification in PUL, with potential to reduce unnecessary hospitalizations and improve patient care.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103035"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of gynecology obstetrics and human reproduction","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468784725001321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Pregnancy of unknown location (PUL) refers to a positive pregnancy test without definitive ultrasound evidence of intrauterine or ectopic pregnancy. It present a diagnostic challenge in early pregnancy management due to the risk of ectopic pregnancy (EP).

Methods

A prospective, observational study was conducted on 179 women presenting with PUL. We assessed the predictive accuracy of the M6P model and analyzed its performance compared to standard clinical, biological, and ultrasound parameters among patients with PUL in a Tunisian population.

Results

The M6P model showed promising performance in stratifying EP risk factors significantly associated with high-risk EP included history of ectopic pregnancy, intrauterine device use, history of pelvic inflammatory disease, and smoking.

Conclusion

The M6P model is a valuable, objective, and reproducible tool for early risk stratification in PUL, with potential to reduce unnecessary hospitalizations and improve patient care.

查看原文本刊更多论文

M6P模型在未知位置妊娠中预测异位妊娠的评价：突尼斯的一项前瞻性单中心研究。

简介：不明位置妊娠（PUL）是指妊娠试验阳性，但没有明确的宫内妊娠或异位妊娠的超声证据。由于异位妊娠（EP）的风险，它提出了早期妊娠管理的诊断挑战。方法：对179例PUL患者进行前瞻性观察性研究。我们评估了M6P模型的预测准确性，并将其与突尼斯人群中PUL患者的标准临床、生物学和超声参数进行了比较。结果：M6P模型对宫外孕史、宫内节育器使用史、盆腔炎史、吸烟史等与高危EP相关的危险因素进行分层，显示出良好的效果。结论：M6P模型是一种有价值的、客观的、可重复的PUL早期风险分层工具，具有减少不必要住院治疗和改善患者护理的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.