Journal of gynecology obstetrics and human reproduction最新文献

{"title":"The impact of Assisted Reproductive Technology on the neonatal prognosis of newborns < 29 weeks gestational age: a retrospective case-control study.","authors":"Andréa Villeneuve, Aude Ansel-Wallois, Géraldine Porcu Buisson, Daniel Cohen, Aurélie Amar Hoffet, Anne Céline Reyss, Yves Jasaitis, Farid Boubred, Blandine Courbiere","doi":"10.1016/j.jogoh.2026.103158","DOIUrl":"https://doi.org/10.1016/j.jogoh.2026.103158","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the neonatal prognosis of preterm infants born before 29 weeks of gestation based on their mode of conception (Medically Assisted Reproduction vs spontaneous pregnancy).</p><p><strong>Design: </strong>A retrospective case-control study was conducted in the neonatal intensive care unit of the Hôpital de la Conception in Marseille.</p><p><strong>Subjetcs: </strong>All preterm newborns under 29 weeks of gestation hospitalized between 2014 and 2020 were included. Newborns conceived through Medically Assisted Reproduction were compared to a control group of newborns from spontaneous pregnancies, matched at a ratio of 1 case to 3 controls.</p><p><strong>Exposure: </strong>Medically Assisted Reproduction MAIN OUTCOME MESURES: The primary outcome was a composite criterion including the number of deaths, bronchopulmonary dysplasia at 36 weeks of gestation, severe intraventricular hemorrhage (grade 3 or higher), severe retinopathy of prematurity (grade 3), and/or necrotizing enterocolitis (grade 2 or higher). Secondary outcomes included Apgar score, cesarean section rate, and average age at discharge from neonatal intensive care.</p><p><strong>Results: </strong>Among the 616 hospitalized newborns, 18.8% were conceived through Medically Assisted Reproduction (n=112). A total of 448 patients were included, with 112 cases and 336 controls. Among the cases, 21 were conceived via intrauterine insemination, 14 through ovulation stimulation with clomiphene, 54 through In Vitro Fertilization, and 23 through IntraCytoplasmic Sperm Injection. Multiple pregnancies were more common in the Medically Assisted Reproduction group (61.6%) compared to spontaneous conception (30.6%). No significant difference was observed in the neonatal prognosis between newborns conceived via Medically Assisted Reproduction and those from spontaneous pregnancies (74.1% vs 77.1%, p=0.52). The cesarean section rate was significantly higher among mothers who underwent Medically Assisted Reproduction (83% vs 59.2%, p<0.05).</p><p><strong>Conclusion: </strong>This study suggests that newborns under 29 weeks of gestation conceived through Medically Assisted Reproduction have a neonatal prognosis comparable to those from spontaneous pregnancies, although cesarean section rates are higher among mothers who used Medically Assisted Reproduction.</p>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":" ","pages":"103158"},"PeriodicalIF":1.6,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From right to reality: Barriers in women's journey to tubal sterilization","authors":"Hélène Alleoud Michi ,&nbsp;Hélène Hoarau ,&nbsp;Vincent Balaya ,&nbsp;Julie Marcadet ,&nbsp;Malik Boukerrou ,&nbsp;Phuong Lien Tran","doi":"10.1016/j.jogoh.2026.103105","DOIUrl":"10.1016/j.jogoh.2026.103105","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103105"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which would you prefer: continuous or only on-demand contraception? International survey by IPSOS","authors":"D Serfaty ,&nbsp;J Escola ,&nbsp;L Klein ,&nbsp;CPJ Talbot ,&nbsp;L Longfier ,&nbsp;F Carrois","doi":"10.1016/j.jogoh.2026.103106","DOIUrl":"10.1016/j.jogoh.2026.103106","url":null,"abstract":"<div><h3>Introduction</h3><div>In France, contraception use is lowest among women aged 40 and over, and the abortion rate in this age group remains stable or slightly increases. This may be due to conventional contraceptive methods being unsuitable for these women, who are less fertile and often less sexually active. On-demand contraceptive methods include male and female condoms, diaphragms, pericoital pills and spermicides. While these methods are not currently recommended due to lower effectiveness compared to continuous contraception, they may be appropriate for women in their later reproductive years, given their reduced pregnancy risk. The IPSOS survey assessed women's contraceptive preferences, particularly for continuous <em>versus</em> on-demand methods.</div></div><div><h3>Material and methods</h3><div>A 10-minute online survey was taken by 900 women (300 from France, 300 from Algeria and 300 from Russia), randomly drawn from Ipsos database in February 2023. Half were aged between 18 and 39 and half between 40 and 50. Statistical analysis was performed on unweighted samples, the sample size insuring robustness.</div></div><div><h3>Results</h3><div>Overall, 63 % of women were open to on-demand contraception. Among those aged 40 and over (<em>n</em> = 450), 59 % favored it, with country-specific variations (49 % in France, 55 % in Algeria, and 73 % in Russia).</div></div><div><h3>Discussion</h3><div>This international study highlights the need for an on-demand contraception, particularly for women over 40. Combining it with continuous contraception could reduce the number of unplanned pregnancies and abortions, whose current rate in France is the highest since 1990.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103106"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and clinical value of virtual reality based on 3D model in colorectal endometriosis for surgical planning","authors":"Camille Martel ,&nbsp;Claire Zhang ,&nbsp;Lise Lecointre ,&nbsp;Catherine Roy ,&nbsp;Emilie Faller ,&nbsp;Thomas Boisramé ,&nbsp;Luc Soler ,&nbsp;Cherif Akladios","doi":"10.1016/j.jogoh.2025.103103","DOIUrl":"10.1016/j.jogoh.2025.103103","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal endometriosis (CRE) is one of the most severe forms of deep pelvic endometriosis with a high risk of major postoperative complications. While pelvic MRI is the gold standard for preoperative assessment, its interpretation remains challenging. This study aimed to evaluate the feasibility and potential clinical value of three-dimensional (3D) MRI-based modeling as a tool to support preoperative planning in patients with CRE.</div></div><div><h3>Methods</h3><div>All patients who underwent laparoscopic segmental rectosigmoid resection for deep endometriosis (DE) between January 1, 2008 and December 31, 2019 in the gynecologic surgery department of Hautepierre Hospital with preoperative pelvic MRI performed at the Strasbourg New Civil Hospital were retrospectively included. Segmentation was carried out by a gynecologic surgeon using VP Planning® software on T2-weighted 3D axial images. The resulting 3D models were then evaluated by four expert gynecologic surgeons using a structured questionnaire assessing anatomical accuracy and potential usefulness for surgical planning.</div></div><div><h3>Results</h3><div>Fourteen 3D models of the pelvic anatomy were produced. The comparison of the modeling data with operative reports was satisfactory with a good correlation of the modeling with the operative findings. The interest of modeling in surgical planning were evaluated at 7.6 / 10. Surgeons believed that 3D modeling could help them understand the complexity of the surgery in 79 % of the cases presented.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the technical feasibility of 3D surface-based modeling of CRE using pelvic MRI. The 3D models obtained seems to have interesting potential in the context of pre operative planning.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103103"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy chances and obstetrical outcomes after egg donation according to the maternal indication","authors":"Saadoun Cheina ,&nbsp;Zimmermann Appoline ,&nbsp;Gnisci Audrey ,&nbsp;Deveze Carole ,&nbsp;Guillemain-Metzler Catherine ,&nbsp;Courbiere Blandine","doi":"10.1016/j.jogoh.2025.103102","DOIUrl":"10.1016/j.jogoh.2025.103102","url":null,"abstract":"<div><h3>Introduction</h3><div>Infertility constitutes a major public health issue, and requests for oocyte donation, initially indicated in cases of premature ovarian insufficiency or to avoid the transmission of a maternally inherited genetic disease, are currently increasing due to the rise in requests following IVF failure or in cases of age-related infertility. Pregnancies resulting from oocyte donation are associated with increased obstetric morbidity compared with spontaneous pregnancies or those resulting from IVF with autologous oocytes. However, the influence of the initial indication for oocyte donation on obstetric outcomes is still debated.</div></div><div><h3>Objective</h3><div>To evaluate clinical pregnancy rates and obstetric outcomes of singleton pregnancies after oocyte donation according to the maternal indication.</div></div><div><h3>Materials and Methods</h3><div>A retrospective single-center study including infertile women aged 18 to 43 years, managed with oocyte donation between 2012 and 2024 in our Assisted Reproductive Technology center. Clinico-biological data and the outcomes of oocyte donation cycles were analyzed. The obstetric outcomes of singleton ongoing pregnancies were studied according to the etiology of oocyte donation: group 1 (intra-couple IVF failure), group 2 (genetic cause), group 3 (idiopathic POI), group 4 (iatrogenic POI).</div></div><div><h3>Results</h3><div>A total of 276 women underwent 586 oocyte donation cycles, with embryo transfer performed in 88% of cases under hormone replacement therapy. The clinical pregnancy rate per cycle was 30%, significantly higher in the group 3 idiopathic POI (44.2%,). The live birth rate per cycle was 21% in the overall population and 31% in the group 3 (<em>p</em> = 0.014). Among the 107 singleton pregnancies resulting in live birth, the most frequent complications were gestational diabetes (23 %) and hypertensive disorders (23%), with no significant difference between the 4 groups. The overall caesarean section rate was 44%.</div></div><div><h3>Conclusion</h3><div>Patients with idiopathic POI achieve better pregnancy and live birth rates after oocyte donation, without a specific increase in obstetric complications compared with other indications. The increased obstetric morbidity observed after oocyte donation underlines the need for personalized pregnancy follow-up.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103102"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of secondary surgery and PARP inhibition in platinum-sensitive ovarian cancer relapse","authors":"Stefano Fucina ,&nbsp;Nicolò Clemente ,&nbsp;Anna Del Fabro ,&nbsp;Luca Martella ,&nbsp;Emilio Lucia ,&nbsp;Fabio Puglisi ,&nbsp;Michele Bartoletti ,&nbsp;Gustavo Baldassarre ,&nbsp;Fabiola Giudici ,&nbsp;Vincenzo Canzonieri ,&nbsp;Antonino Ditto","doi":"10.1016/j.jogoh.2026.103108","DOIUrl":"10.1016/j.jogoh.2026.103108","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the benefit of secondary cytoreductive surgery (SCS) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC), and to evaluate how survival outcomes are influenced by second-line PARP inhibitor maintenance therapy.</div></div><div><h3>Methods</h3><div>This retrospective study included 52 patients with platinum-sensitive recurrent EOC treated at the National Cancer Institute of Aviano, Italy, between 2015 and 2022. Patients received either SCS followed by chemotherapy (SCS+CT group) or chemotherapy alone (CT-only group). The primary endpoints were progression-free survival (PFS) and post-recurrence survival (PRS). Secondary analyses explored the impact of second-line PARPi maintenance on survival outcomes within each treatment group.</div></div><div><h3>Results</h3><div>Patients in the SCS+CT group experienced significantly longer PFS compared to those in the CT-only group (median 19.2 vs. 10.0 months, <em>p</em>=0.007). Among patients receiving PARPi maintenance, the benefit was even more pronounced: median PFS was 40.3 months in the SCS+CT group versus 21.9 months in the CT-only group (p=0.026). A non-significant trend toward improved PRS was observed in the SCS+CT group (48.3 vs. 36.0 months, <em>p</em>=0.23). PARPi maintenance was associated with longer PRS in both treatment arms (<em>p</em>=0.0056 for SCS+CT; p=0.033 for CT-only).</div></div><div><h3>Conclusions</h3><div>In patients with platinum-sensitive recurrent EOC, SCS combined with chemotherapy significantly improves PFS, particularly when followed by second-line PARPi maintenance. These findings support the role of SCS in carefully selected patients and emphasize the synergistic effect of integrating surgical and molecularly targeted strategies.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103108"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of topical anesthetics during intrauterine device insertion: A systematic review","authors":"Sylvine Carrondo Cottin ,&nbsp;Geneviève Asselin ,&nbsp;Mathieu Leboeuf ,&nbsp;Marc Rhainds","doi":"10.1016/j.jogoh.2026.103104","DOIUrl":"10.1016/j.jogoh.2026.103104","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103104"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas embolism during operative hysteroscopy: Analysis of the Gynerisq experience feedback database","authors":"Amélie Sarribouette ,&nbsp;Antoine Netter ,&nbsp;Véronique Lejeune ,&nbsp;Alain Proust ,&nbsp;Emmanuel Peigné ,&nbsp;Philippe Boisselier ,&nbsp;Aubert Agostini","doi":"10.1016/j.jogoh.2026.103111","DOIUrl":"10.1016/j.jogoh.2026.103111","url":null,"abstract":"<div><h3>Objective</h3><div>Complications of operative hysteroscopy (OH) are rare and usually minor. However, in rare cases, certain complications such as gas embolism (GE) can be life-threatening. The objective of this study was to analyze the circumstances and outcomes of GE cases occurring during OH.</div></div><div><h3>Materials and Methods</h3><div>This retrospective descriptive observational study included all cases of GE during OH reported between 2016 and 2023 in the experience feedback (REX) database of Gynerisq, an organization accredited in risk management in Gynecology and Obstetrics by the French National Authority for Health (HAS).</div></div><div><h3>Results</h3><div>Among 318 reported OH complications, 14 cases of GE were identified (4.4%). The procedures involved fibroid resection in 11 patients (78.6%) and endometrectomy in 3 patients (21.4%). Bipolar energy was used in all cases. Of the 14 GE cases, 5 had serious consequences, including cardiac arrest and intensive care unit (ICU) admission. Eight cases were considered probably avoidable by the reporting practitioners, particularly due to non-compliance with the recommendations of the French National College of Gynecologists and Obstetricians (CNGOF), such as unpurged tubing and failure to monitor intrauterine pressure.</div></div><div><h3>Conclusion</h3><div>This analysis shows that all reported GEs occurred during procedures using bipolar energy and following fibroid or endometrial resection. <u>However, a causal relationship between bipolar energy and GE cannot be established.</u> Further studies are required to assess the role of bipolar energy and the conditions of its use in the occurrence of GE.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103111"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer in women eligible for HPV-vaccination in the Netherlands","authors":"Luc van Lonkhuijzen ,&nbsp;Constantijne H. Mom ,&nbsp;Maaike van der Aa","doi":"10.1016/j.jogoh.2026.103107","DOIUrl":"10.1016/j.jogoh.2026.103107","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103107"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HTLV-1, a neglected disease among breastfeeding women from endemic areas: a national survey of knowledge and screening practices in France","authors":"Diane Brebant ,&nbsp;Olivier Picone ,&nbsp;Nadja van Ginneken ,&nbsp;Christelle Vauloup-Fellous ,&nbsp;Nicolas Vignier","doi":"10.1016/j.jogoh.2025.103084","DOIUrl":"10.1016/j.jogoh.2025.103084","url":null,"abstract":"<div><h3>Background</h3><div>Screening of some infectious diseases is consistently recommended during pregnancy in France. Although Human T lymphotropic virus type 1 (HTLV-1) infection is a contraindication for breastfeeding, its screening is not routinely recommended as it is uncommon in a native mainland French population. However, HTLV-1 screening should be recommended among women from endemic countries. This study aims to evaluate HTLV-1 knowledge and screening practices of French healthcare professionals among pregnant women.</div></div><div><h3>Methods</h3><div>A French national professional practice evaluation study was conducted in 2022. An electronic questionnaire was distributed to midwives, gynecologists, and general practitioners in partnership with medical societies, and hospitals.</div></div><div><h3>Results</h3><div>A total of 936 participants were included, 75.4% (n=706) of whom were midwives and 21.8% were gynecologists (n=204). Among the participants, 62.1% had outpatient practice and 71.1% had never received previous specific training in obstetric infectious diseases. Only 27.5% of participants reported HTLV-1 as a contraindication to breastfeeding. Of these, a significant proportion had prior specific training in obstetric infectious diseases and practiced in the Paris region or endemic French overseas territories. Knowledge of countries that should lead to HTLV-1 screening was limited and appeared to vary among participants.</div></div><div><h3>Conclusion</h3><div>This national practice evaluation study highlighted the widespread lack of awareness of the issue of HTLV-1 infection. Further studies are needed to assess HTLV-1 seroprevalence in pregnant women (in France or similar European countries), and to evaluate relevance of targeted screening and psychological impact of a positive diagnosis.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103084"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}