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a-Amilaz Molekülündeki Bazı Grupların Enzim Aktivitesi Hakkında
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-06-26 DOI: 10.16883/JFPIU.27444
Nevzat Öner ve Nur Ülgür-Alçitepe
{"title":"a-Amilaz Molekülündeki Bazı Grupların Enzim Aktivitesi Hakkında","authors":"Nevzat Öner ve Nur Ülgür-Alçitepe","doi":"10.16883/JFPIU.27444","DOIUrl":"https://doi.org/10.16883/JFPIU.27444","url":null,"abstract":"B. subtuis a-amilaz cozeltisinin glukozlu ortamda TJV (279 mu.) absorpsyonu ve Folin-fenol ve Diazo reaktifleri ile verdigi renk re­aksiyonlarinin siddetleri glukoz ihtiva etmeyen enzim cozeltisine ki­yasla daha dusuk bulundu. Bu durum glukoz molekulu ile enzimde­ki urozil bakiyeleri arasinda karsilikli bir etkinin bulunmasi ile izah edilebilir. Bu karsilikli etki tirozil bakiyelerinin karakteristik reaksi­yonlarini vermesine engel oldugu halde glukozlu ortamda aktivitenin aynen devam etmesi, enzimin tirozil bakiyelerindeki ■—OH gruplari­nin aktivitede rolu olmadigi kanisini uyandirmaktadir. Bundan bas­ka, glukozsuz ortama —SH gruplarinin aktivatoru olan, sistein ila­vesiyle enzim aktivitesinde bir artma musahede edilmesi enzimin sis-teinil bakiyelerindeki —SH gruplannm aktivitede rol oynadigini gos­termektedir. B.s. cc-amilazmdaki tirozil ve sisteinil bakiyelerinin en­zim aktivitesindeki rolu tartisilmistir.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"31 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79309092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Türk Kitre Zamkının Menşei ve Terkibi Hakkında
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-06-25 DOI: 10.16883/JFPIU.45294
Asuman Baytop va Tekand Gözler
{"title":"Türk Kitre Zamkının Menşei ve Terkibi Hakkında","authors":"Asuman Baytop va Tekand Gözler","doi":"10.16883/JFPIU.45294","DOIUrl":"https://doi.org/10.16883/JFPIU.45294","url":null,"abstract":"Kitre zamki, yurdumuzda Mugla'dan Hakkari'ye kadar uzanan ge­nis alanlarda elde edilir. Bu saha uc bolgeye ayrilir. Bu maddeyi bize g'inilermis olan Prof. Dr. R. Paris'e tesekkur ederiz. Bati bolgede zamk, sadece Astragalus microcephalus Willd- tu­runden ve bitkiyi ozel surette yaralamakla elde edilir. Bu zamka Yap­rak kitre zamki adi verilir ve 5 kaliteye ayirilir. Orta bolgede zamk, bati bolgede oldugu gibi sadece A. micro­cephalus Willd. turunden, ayni usulle elde edilir ve ayni kalitelere ayi­rilir. Dogu bolgede zamk, A. microcephalus Will., A. gummifer La-bill., A. kurdicus Boiss, var. kurdicus ve var. muschianus (Kotschy et Boiss.) Chamb. bitkilerinden, bitki uzerindeki tabii zamk sizintilarinin toplanmasi suretiyle, Firde ve Traganton adlari ile bilinen iki cins zamk elde edilir. Bu dort geven disinda, baska Astragalus turlerine ait bitkiler uze­rinde de tabii olarak sizan zamk parcalari gorulmus, fakat bunlardan faydalanilmadigi musahede edilmistir. Turkiye'de elde edilen kitrenin ticari kalitelerinin analitik ozellik­leri Cetvel I de gosterilmistir. Degisik farmakopelerin kitre zamki icin istedigi degerler de Cetvel II de verilmistir. Bu iki tablonun mukaye­sesinden anlasiliyor ki Yaprak kitrenin Fiyor ve Beyaz kaliteleri ile Firde kitrenin Birinci kalitesi, farmakope standartlarina uygundur ve eczacilik tekniginde kullanilmaga elverislidir. Astragalus microcephalus, A. gummifer ve A. kurdicus var. mus-chianus uzerinde bizzat toplanan zamk orneklerinin hidrolizinde tes­pit edilen maddeler Cetvel III de gosterilmistir. A. gummifer ve A. kurdicus zamklarinin hidroliz urunleri arasin­da D-galakturonik asit, D-galaktoz, L-arabinoz, D-ksiloz, L-ramnoz tes­his edilmistir. A. microcephalus zamki, bu iki ture ait zamklardan L-fukoz ihtiva etmesiyle ayrilir.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"30 1","pages":"56-65"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79697720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Türkiye Bitkileri Üzerinde Kimyasal Araştırmalar, II
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-06-25 DOI: 10.16883/JFPIU.32971
Turhan Baytop, Günay Özcöbek Gülsüm Alpuğan
{"title":"Türkiye Bitkileri Üzerinde Kimyasal Araştırmalar, II","authors":"Turhan Baytop, Günay Özcöbek Gülsüm Alpuğan","doi":"10.16883/JFPIU.32971","DOIUrl":"https://doi.org/10.16883/JFPIU.32971","url":null,"abstract":"Ekserisi Trabzon bolgesi (Zigana dagi) ve Trakyadan toplanmis olan 100 bitki turu uzerinde yapilan ilk arastirmalar sonunda 38 tur­de tanen, 78 turde glikozit ve 50 turde alkaloit bulundugu tespit edil­mistir (Tablo I). Literatur(3-8) ile yapilan karsilastirmada, alkaloit tespit edilen turlerden 27 sinde alkaloit bulunduguna dair bir kayda rastlanma­mistir. Alkaloit tasidigi ilk defa gosterilen turler sunlardir Anthemis austrA­aca Jacq., Butomus umbellatus L., Centaurea cal-citrapa L., C. salonitana Vis., Cynanchum acutum L., C. vincetoxicum Pers., Hyacinthus orientalis L., Lemna gibba L., L. polyrhiza L., Lepi-dium latifolium L., Lycium barbarum L„ L. europaeum L., Marsdenia erecta R. Br., Oenanthe phellandrium Lam., Oe. silaifolia M. B., Parie-taria vulgaris Hill., Petasites albus L., Phacelurus digitatus (S. etSm.) Gris., Polystichum setiferum (Forsk.) Woynar, PotamogetA³n fluitans Roth, P. perfoliatus L., Scolymus maculatus L., Smyrnium olusatrum L., S. perfoiiatum L., Thalictrum lucidum L., Valeriana alliariaefolia Vahi., V. dioscoridis S. et Sm.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"36 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90594474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Türkiyede Yetişen Peganum harmala L. Üzerinde Kimyasal Araştırmalar
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-06-25 DOI: 10.16883/JFPIU.81286
Hüsamettin Kutlu ve Hayriye Amã„L Hüsamettin Kutlu ve Hayriye Amã„L
{"title":"Türkiyede Yetişen Peganum harmala L. Üzerinde Kimyasal Araştırmalar","authors":"Hüsamettin Kutlu ve Hayriye Amã„L Hüsamettin Kutlu ve Hayriye Amã„L","doi":"10.16883/JFPIU.81286","DOIUrl":"https://doi.org/10.16883/JFPIU.81286","url":null,"abstract":"Bu calismamizda Nigde-Bor havalisinden toplanan P. harmala L. (Zygophyllaceae) bitkisinin olgun tohumlarinin aktif prensipleri in­celenmistir. P. harmdla tohumlan |% 8.4 kadar rutubet, ihtiva eder; yakil­diginda f/o 7.05 kul birakir. Asitte cozunmeyen kul !%0.78; sulfatli kul % 9.061 dir. Tohumlar % 14.24 sabit yag ihtiva eder. Tohum­larda steroller, tanenler, serbest ve kombine sekerler, saponinler, antrakinon turevleri ve flavonlar bulunmamistir. Tohumlardan muhtelif cozuculerle muamele edilerek kuru eks-tre miktar tayini yapilmis ve total alkaloit miktarlari, sulfurik asit­le titrimetrik veya Reinecke tuzu yardimiyle gravimetrik ve titri-metrik olarak tayin edilmistir; en yuksek kuru ekstre ve total alka­loit miktari metanol ile yapilan ekstraksiyon mahsulunde bulunmus olup % 34.90 kuru ekstre; !% 7.012 total alkaloittir. Reinecke tuzu ile gravimetrik tayinde total alkaloit %6.40; titrimetrik tayinde %7.10 dur. Asitli maseralarla elde edilen en yuksek total alkaloit, % 15 lik asetik asitle hazirlanan mesarada olup <% 6.028 dir. Ekstrelerin kagit ve ince tabaka kromatograf ileriyle tetkiklerin­de ; alkaloit reaktifleriyle reaksiyon veren ve UV de muhtelif renkte fluoresans gosteren belli basli uc esas leke ile, alkaloit karakterinde olmayan boyar maddelere ait lekeler gorulmustur. Bunlardan UV de mor fluoresans gosterenin harmin (C :a H 12 N 2 0); yesil fluoresans gos­terenin tetrahidroharmin (C ia HiaN 2 0) oldugu standart madde ile kontrol edilerek, ayrica C, H, N, tayini ve UV, IR, NMR analizleriyle ispatlanmistir. Sari fluoresans gosteren maddenin C, H, N, tayini; asetil-6-metok-sitriptamin formulune uymaktadir (C 13 HioN 2 0 2 ). Bu madde UV alan­da monosubstitue indole ait bir maksimum vermistir. Tecrit edilmis alkaloitlerin metanollu ekstreye gecen miktarlari teker teker spektrofotometrik olarak tayin edilmis ve harmin icin % 1.965; tetrahidroharmin icin f/o 3.957 bulunmustur. Sari fluoresans gosteren madde cok dayaniksiz oldugundan, standart solusyonlari hazirlanamamis, miktari da tespit edilememistir.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"28 1","pages":"133-147"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78130493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyoscyamus leptocalyx Üzerinde Botanik Araştırma
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-06-25 DOI: 10.16883/JFPIU.97661
Asuman Baytop
{"title":"Hyoscyamus leptocalyx Üzerinde Botanik Araştırma","authors":"Asuman Baytop","doi":"10.16883/JFPIU.97661","DOIUrl":"https://doi.org/10.16883/JFPIU.97661","url":null,"abstract":"Hyoscyamus leptocalyx Stapf, cok dar yayihsli bir Hyoscyamus tu­rudur. Bugune kadar Mardin'de (Guneydogu Anadolu) ve Mardin'in yakinlarinda bulunmustur. Kaya catlaklarinda alcak kumeler teskil et­mesi, ciceklerinin altin rengi, yapraklarinin ozel sekli (Şek. 1), mey-valarimn kucuklugu, meyva kaliksinin otsu ve yumusak olup loplari­nin asagi kivrik durusu (Şek. 1) ile tamhr. Yapraklarinin anatomik ozellikleri Şek. 2-6 da belirtilmistir. Tuyler, sapi 2-7 hucreli ve basi bir hucreli olan salgi tuylerinden ibarettir (Şek. 6). Billurlar buyuk­tur ve baslica druz seklindedir. Bunlarin yaninda farkli sekilde birle­sik billurlara ve basit billurlara tesaduf edilir (Şek. 6).","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"601 1","pages":"138-146"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76793466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
WILD EDIBLE PLANTS IN KARAMAN (SOUTHERN TURKEY) 卡拉曼(土耳其南部)野生可食植物
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-01-01 DOI: 10.16883/JFPIU.64877
S. K. N. Özhatay
{"title":"WILD EDIBLE PLANTS IN KARAMAN (SOUTHERN TURKEY)","authors":"S. K. N. Özhatay","doi":"10.16883/JFPIU.64877","DOIUrl":"https://doi.org/10.16883/JFPIU.64877","url":null,"abstract":"An ethnobotanical study was carried out in Karaman province (South of Central Anatolia) and wild edible species were identified used as food, spice, pickle, appetizer, mastic, tea and coffee. Identified 61 wild edible plant species belonging to 20 families of the 57 flowering plants, 2 fungi and 1 lichen species were collected from different localities in Karaman. The highest species number is found for Labiatae family (19 species) is followed by Compositae (8 species), Rosaceae (5 species), Caryophyllaceae, Polygonaceae (3 species) and Anacardiaceae, Malvaceae, Chenopodiaceae and Urticaceae (2 species). The rest of the 11 families represented by only 1 species.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"5 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88769648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
RARE AND ENDEMIC PIMPINELLA SPECIES FROM TURKEY: P. SINTENISII H. WOLFF 土耳其罕见的特有种鸡皮皮虫;p. sinintenisii h. wolff
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-01-01 DOI: 10.16883/JFPIU.95918
E. A. A. Akpulat
{"title":"RARE AND ENDEMIC PIMPINELLA SPECIES FROM TURKEY: P. SINTENISII H. WOLFF","authors":"E. A. A. Akpulat","doi":"10.16883/JFPIU.95918","DOIUrl":"https://doi.org/10.16883/JFPIU.95918","url":null,"abstract":"Pimpinella sintenisii H. Wolff was collected by Sintenis in 1888 from Mardin, Southern Turkey named as Reutera intermedia Stapf. In 1937 Wolff. changed the genus as Pimpinella and named P. sintenisii. Its distribution recorded in Flora of Turkey Mardin, Siirt and Northern Iraq. The specimens from Northern Iraq were (1961) described as a new species P. nephrophylla Rech. F. H. Rieldl and it is also recorded in Turkey by Ertekin. P. sintenisii and related 3 species are yellow flower and distributed in Southern Turkey. A comprehensive study has been carried out in P. sintenisii, Pimpinella nephrophylla, Pimpinella paucidentata V.A.Matthews and Pimpinella flabellifolia (Boiss.) Benth. ex Drude.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"42 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86730490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A PRELIMINARY ETHNOBOTANICAL SURVEY OF KUMLUCA (ANTALYA) 库姆卢卡(安塔利亚)民族植物学初步调查
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-01-01 DOI: 10.16883/JFPIU.86050
Y. E. Arican, Y. Genç
{"title":"A PRELIMINARY ETHNOBOTANICAL SURVEY OF KUMLUCA (ANTALYA)","authors":"Y. E. Arican, Y. Genç","doi":"10.16883/JFPIU.86050","DOIUrl":"https://doi.org/10.16883/JFPIU.86050","url":null,"abstract":"In this study, 31 plant taxa belonging to 21 families that are used as medicine, food, food conservation, cosmetic and miscellaneous purposes are documented in Kumluca district of Antalya City. While 83,8% of these taxa (26 species) are used for medicinal purposes, 25% of them (8 species) are used for nutritional purposes. The information gathered by investigating the local usage of the plants is compared with the literature.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"11 1","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90683562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
AN OVERVIEW TO CENTAUREA s.l. (ASTERACEAE) BASED ON HERBARIUM SPECIMENS OF ISTE 基于ISTE植物标本馆标本的半人马属(菊科)概述
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-01-01 DOI: 10.16883/JFPIU.10823
M. Bona
{"title":"AN OVERVIEW TO CENTAUREA s.l. (ASTERACEAE) BASED ON HERBARIUM SPECIMENS OF ISTE","authors":"M. Bona","doi":"10.16883/JFPIU.10823","DOIUrl":"https://doi.org/10.16883/JFPIU.10823","url":null,"abstract":"In this study; a list of the Centaurea L. taxa kept in (ISTE) “Herbarium of Faculty Pharmacy, University of Istanbul” is given. The genus Centaurea is the third largest genus in terms of species number in Turkey. There are 217 species (146 endemics), 36 subspecies (22 endemics), 28 varieties (16 endemics) totally 255 taxa and endemism ratio is 66.8 %. ISTE has an important Centaurea collection with 146 species (67 endemics), 28 subspecies (18 endemics), 20 varieties (9 endemics) totally 171 taxa (83 endemics). The collection also contains 16 European species. Basic chromosome numbers of the genus were reported as x = 6, 7, 8, 9, 10, 11, 12, 13, 15. The list which given in this paper contains; ISTE specimens with voucher numbers, endemism, and chromosome numbers.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"57 1","pages":"121-137"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83689476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
INVOLVEMENT OF MAIN OXIDATIVE STRESS MECHANISMS IN THE TOXICITY OF BENOMYL AND CARBENDAZIM IN RATS 苯甲酰和多菌灵对大鼠毒性的主要氧化应激机制参与
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2013-01-01 DOI: 10.16883/JFPIU.87601
Sadik Catalgol, B. Alpertunga
{"title":"INVOLVEMENT OF MAIN OXIDATIVE STRESS MECHANISMS IN THE TOXICITY OF BENOMYL AND CARBENDAZIM IN RATS","authors":"Sadik Catalgol, B. Alpertunga","doi":"10.16883/JFPIU.87601","DOIUrl":"https://doi.org/10.16883/JFPIU.87601","url":null,"abstract":"SUMMARY This study aimed to evaluate the role of oxidative stress in toxicity induced by BNL (benomyl) and its metabolite CBZ (carbendazim), which are systemic broad-spectrum benzimidazole fungicides. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Rd), γ−glutamyl transpeptidase (GGT) and glutathione-S-transferase (GST) as well as the levels of malonyldialdehyde (MDA), being a lipid peroxidation marker and reduced glutathione (GSH) were measured in the liver, kidney, testis and brain tissues of the rats, after acute exposure of the two fungicides and their mixture. In all tissues, it was observed that MDA levels were increased and changes in antioxidant defense system were occurred. The induction of oxidative stress manifested as changes in the activity and/or levels of antioxidative parameters has been suggested as the mechanism by which BNL and CBZ induces their toxic effects. OZET Bu calismada, genis spektrumlu sistemik benzimidazol grubu fungusidlerden olan BNL (benomyl) ve metaboliti CBZ (carbendazim)’ nin toksik etki mekanizmalarinda oksidatif stresin rolu arastirildi. BNL, CBZ ve karisimlarina akut maruziyet sonrasi sicanlarin karaciger, bobrek, testis ve beyin dokularinda oksidatif stres gostergesi olarak lipid peroksidasyon son urunu malondialdehid (MDA) ve indirgenmis glutatyon (GSH) seviyeleri, superoksid dismutaz (SOD), katalaz (CAT), glutatyon peroksidaz (GSHPx), glutatyon reduktaz (GSH-Rd), gama glutamil transpeptidaz (GGT) ve glutatyon-S-transferaz (GST) antioksidan enzim aktivitelerinin tayini yapildi. Tum dokularda MDA duzeylerinin arttigi ve antioksidan savunma sistemlerinde degisiklik oldugu gozlendi. BNL ve CBZ’nin toksisitesinde, antioksidan parametrelerin aktivite ve/veya duzeylerinde oksidatif stresin induksiyonu sonucu gorulen degisikliklerin rol oynadigi sonucuna varildi. Key words: Oxidative Stress, Benomyl, Carbendazim, Pesticide toxicity","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"72 1","pages":"103-120"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80517505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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