Journal of Faculty Pharmacy of Istanbul University最新文献

Check-list of additional taxa to the supplement flora of Turkey VII 土耳其补充植物区系新增分类群核对表7

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2017-10-10 DOI: 10.5152/ISTANBULJPHARM.2017.006

N. Özhatay, Ş. Kültür, B. Gürdal

引用次数: 325

The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility 内分泌干扰物及遗传易感性对男性不育的影响

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-26 DOI: 10.16883/JFPIU.44440

Merve Arıcı Gül Özhan

{"title":"The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility","authors":"Merve Arıcı Gül Özhan","doi":"10.16883/JFPIU.44440","DOIUrl":"https://doi.org/10.16883/JFPIU.44440","url":null,"abstract":"Abstract: Reproductive functions in men are impaired by many environmental, physiologic, and genetic factors. Xenobiotics (e.g. phthalate, alkylphenols, heavy metals, bisphenol A, ets) are the majority of the environmental factors which happen adverse effects with covalent interactions between intermediate metabolites and cellular macromolecules. The recent publications regarding infertility have stated that the substances do not only interfere human’s normal hormone functions, but also cause the reproductive disorders such as testicular germ line cancer and prostate hyperplasia. The xenobiotics disrupting endocrine system are metabolized by the enzyme involved phase I (e.g., CYP450) and II (e.g., NAT, SULT) enzymes. Most of the enzymes are polymorphic and genetic variants modify the enzyme catalytic activities. Thus, the effects of endocrine disrupting chemicals might vary between individuals. To date, the impact of genetic variability in the capacity of metabolizing xenobiotics has not been extensively studied on male reproductive functions. The relation between environmental and genetic factors and infertility has not been shown clearly. Therefore, we aimed to evaluate the interaction between endocrine disruptors’ exposure and polymorphisms involved in genes (e.g., DAZL, MTHFR, POLG) in male infertility risk by data obtained from previously studies. Key words: Polymorphism, endocrine disruptors, reproduction, testis, fertility","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82196052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing certain ethnobotanical objects in Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany 介绍伊斯坦布尔大学药学院药物植物学系的某些民族植物学对象

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-22 DOI: 10.16883/JFPIU.99364

Y. Yeşil

{"title":"Introducing certain ethnobotanical objects in Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany","authors":"Y. Yeşil","doi":"10.16883/JFPIU.99364","DOIUrl":"https://doi.org/10.16883/JFPIU.99364","url":null,"abstract":"Abstract: In terms of plant diversity, Turkey is one of the richest countries in the world. In addition to studying the country’s rich flora, a number of ethnobotanical studies have recently been conducted in Turkey. The diversity of plant usage in the ethnobotanical studies revealed the multicultural structure of Turkey. Documentation of traditional knowledge through ethnobotanical studies is important for the conservation and utilization of biological resources. As well as documents obtained from ethnobotanical research being important, objects collected during the study are important at the same time. The idea of collecting ethnobotanical objects in Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany arose in 2007. Then ethnobotanical objects were collected from around Turkey. They include medicines, foods and ethnographic objects (such as musical instruments, agricultural tools and utensils) as well as plant specimens (including seeds, roots, fruits and oils). This study aims to introduce certain objects found in Istanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany. Key words: Ethnobotany, ISTE, Pharmacy, Istanbul, Turkey.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82814250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological and genetic analysis of cellular sodium and lithium response/resistance behavior using the yeast Saccharomyces cerevisiae as a model organism 以酿酒酵母为模式生物的细胞钠锂响应/抗性生理和遗传分析

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-22 DOI: 10.16883/JFPIU.54980

Ş. H. Tekarslan, Ceren Alkim, C. Hunte, Z. P. Çakar

{"title":"Physiological and genetic analysis of cellular sodium and lithium response/resistance behavior using the yeast Saccharomyces cerevisiae as a model organism","authors":"Ş. H. Tekarslan, Ceren Alkim, C. Hunte, Z. P. Çakar","doi":"10.16883/JFPIU.54980","DOIUrl":"https://doi.org/10.16883/JFPIU.54980","url":null,"abstract":"Abstract: The yeast Saccharomyces cerevisiae is a simple eukaryote and an excellent model organism for molecular biology. In this study, a NaCl-resistant S. cerevisiae mutant obtained by inverse metabolic engineering was used as a model to investigate responses and resistance behavior to NaCl, LiCl, KCl, TMA, spermine and sorbitol stresses., at physiological and genetic levels. The physiological spot test results revealed that the NaCl-resistant yeast mutant showed higher resistance to LiCl and NaCl. Gene expression analysis by qRT-PCR revealed that ENA6 and NHA1 genes of the mutant were induced in the absence and presence of LiCl and NaCl. The dysfunction of Na+/H+ antiporters are related to several diseases such as hypertension, epilepsy, postischemic myocardial arrhythmia, gastric and kidney disease, diarrhea, and glaucoma. Thus, the NaCl-resistant yeast mutant could be used to understand cellular sodium and lithium resistance mechanisms and the function of Na+/H+ antiporters also in higher eukaryotic organisms, including humans. Key words: Saccharomyces cerevisiae, stress resistance, salt-resistance , lithium resistance, NHA1","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81527658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphological characteristics of exported taxa as Oregano from Turkey I: Origanum 土耳其牛至出口分类群的形态特征ⅰ:牛至属

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-22 DOI: 10.16883/JFPIU.31809

N. Sadıkoğlu, N. Özhatay

引用次数: 4

Twenty years of research on Aloe vera 二十年来对芦荟的研究

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-22 DOI: 10.16883/JFPIU.90447

N. Akev, A. Can, N. Sütlüpinar, Eda Candoken, N. Ozsoy, T. Ozden, R. Yanardag, E. Üzen

{"title":"Twenty years of research on Aloe vera","authors":"N. Akev, A. Can, N. Sütlüpinar, Eda Candoken, N. Ozsoy, T. Ozden, R. Yanardag, E. Üzen","doi":"10.16883/JFPIU.90447","DOIUrl":"https://doi.org/10.16883/JFPIU.90447","url":null,"abstract":"Abstract: Aloe vera, sometimes referred as a “miraculous” or “wonder” plant, has been used by mankind for centuries for the treatment of different disorders due to the inner gel of its succulent leaves. Medical usage and applications of the main species, namely Aloe vera (L.) Burm. f. are mainly attributed to immunomodulatory or antioxidant activities. Our work on A. vera has begun with the separation of anthraquinones and continued with the purification and characterization of the lectins. In another study, hypoglycemic effect of A. vera leaf extracts was assayed in vivo, followed by the effect of the extracts on several tissues in diabetic rats. A. vera has shown a significant prophylactic effect on Ehrlich ascites tumour cells when given before tumour inoculation in mice. This effect was also seen with the purified lectin and attributed to the immunomodulatory effect of the plant. Assuming that its benefit could also be attributed to the antioxidant activity, the antioxidant potential of the leaves aqueous extract was evaluated. The leaf skin extract showed good antioxidant capacity in all tests while the inner gel did not exhibit any activity. Our work on A. vera continues on the research of the potential use of the plant leaves as anticancer and enzyme inhibitory agent. Key words: Aloe vera, antioxidant, antitumour, antidiabetic, immunomodulatory","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82564046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Quality by design (QbD) for pharmaceutical area 医药领域的设计质量(QbD)

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2016-11-22 DOI: 10.16883/JFPIU.81993

B. Aksu, B. Mesut

{"title":"Quality by design (QbD) for pharmaceutical area","authors":"B. Aksu, B. Mesut","doi":"10.16883/JFPIU.81993","DOIUrl":"https://doi.org/10.16883/JFPIU.81993","url":null,"abstract":"Abstract: Recent changes and limited resources for drug development and manufacturing have rendered the conventional pharmaceutical quality assurance approach insufficient and have given rise to new research in these areas. To address these research efforts, the FDA improved and modernized the rules governing pharmaceutical manufacturing and product quality in 2002, thereby realizing a paradigm change in the current Good Manufacturing Practices (cGMP). The Quality by Design (QbD) approach has entered the pharmaceutical industry within the last 10 years after the approval of the ICH Q8 in 2005. QbD is based on an understanding of the target product’s quality profile (QTPP) and an assessment of its risks during the design and development of pharmaceutical dosage forms. By determining the critical quality attributes of the drug, including its active ingredient, its excipients, and the processes and design spaces used during the R&D phase, multi-way tracking during the life cycle of the drug can be achieved. This tracking can provide numerous advantages, including flexibility in licensing by decreasing the variation and type modifications in applications of the pharmaceutical product, which result from minimizing the possible issues arising after the release of the product. When all these data are observed, it is clear that the new QbD approach benefits the authorities, the drug manufacturers and the patient. Although QbD has certain challenges during its early stages, it is thought that QbD will benefit pharmaceutical manufacturers. Keywords: Quality by design (QbD), target product quality profile, critical quality attributes, design space, risk assessment.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82574688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Determination and comparison of the antimicrobial efficacy of alcohol based hand hygiene products 酒精基手卫生用品抗菌效果的测定与比较

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.90661

Ayşe Seher Birteksöz-Tan, S. Dosler, G. Ötük

{"title":"Determination and comparison of the antimicrobial efficacy of alcohol based hand hygiene products","authors":"Ayşe Seher Birteksöz-Tan, S. Dosler, G. Ötük","doi":"10.16883/JFPIU.90661","DOIUrl":"https://doi.org/10.16883/JFPIU.90661","url":null,"abstract":"Abstract: Hand hygiene is a general definition for the act of “hand cleaning” which is important for the control and prevention of infectious diseases in society. Hand hygiene is intended to reduce the number of microorganisms on people’s hands to a non-infectious level. In this study, we assessed the antimicrobial activities of 9 alcohol-based hand hygiene products that are produced in Turkey. The antimicrobial activities of 3 each hand rubs, hand washes, and hand wipes were tested against to Staphylococcus aureus ATCC6538, Escherichia coli ATCC10538, Pseudomonas aeruginosa ATCC15442, Enterococcus hirae ATCC10541 and Candida albicans ATCC10231 according to the European Standard methods (pr)E12054 and EN1275. 70% ethanol+0.3% triclosan and benzyl alcohol+methyl isothiazolinone were the 2 most effective agents within 1 min of treatment, followed by 70% ethanol+0.1% triclosan+benzalkonium chloride and 70% ethanol+0.1% triclosan against Staphylococcus aureus ATCC6538, Escherichia coli ATCC10538, Pseudomonas aeruginosa ATCC15442, Enterococcus hirae ATCC10541 and Candida albicans ATCC10231. According to these results, it was observed that the antimicrobial activity of the studied products was dependent on the composition of products, duration of exposure and the type of product. Key words: Alcohol, hand hygiene, hand gel, hand wash, hand wipe, in vitro antimicrobial activity","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82335264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide 6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-乙酸肼新腙衍生物的合成及抗菌评价

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.58800

N. Güzeldemirci, Dilek Şatana, Ö. Küçükbasmacı

引用次数: 1

Antibacterial and anti-biofilm activities of new chiral and racemic 1,3-Dioxolanes 新型手性和外消旋1,3-二恶氧烷的抗菌和抗生物膜活性

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.90438

S. Dosler, Emel Mataraci, Hatice Başpınar-Küçük, A. Yusufoglu

{"title":"Antibacterial and anti-biofilm activities of new chiral and racemic 1,3-Dioxolanes","authors":"S. Dosler, Emel Mataraci, Hatice Başpınar-Küçük, A. Yusufoglu","doi":"10.16883/JFPIU.90438","DOIUrl":"https://doi.org/10.16883/JFPIU.90438","url":null,"abstract":"Abstract: We investigated the potential anti-microbial and anti-biofilm activities of previously synthesized 1,3-dioxolane derivatives against several pathogen microorganisms. In vitro antibacterial activities of new compounds against Staphylococcus aureus ATCC 29213, S. epidermidis ATCC 12228, Enterococcus faecalis 29212, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352, Proteus mirabilis ATCC 14153 and antifungal activities against Candida albicans ATCC 10231 were investigated. The minimum inhibitory concentrations (MIC), and minimum biofilm eradication concentrations (MBEC) were determined by microbroth dilution technique. As a result, two molecules were found active against the planktonic and biofilms of the E. faecalis and S. epidermidis. The MIC and MBEC values of those two agents were 9.76 - 39.06 mg/L and 2000 - 5000 mg/L, respectively. In addition, they inhibited the biofilm attachment according to time, and they showed the significant inhibitor activity against biofilm formation at 24 h according to their concentrations. According to these results, two 1,3-dioxolane derivatives were active against the planktonic and biofilm cells of some bacteria. Key words: 1,3-dioxolane derivatives, antimicrobial, anti-biofilm, in-vitro activity.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86727402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3