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Journal of Faculty Pharmacy of Istanbul University最新文献

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Professor Asuman Baytop (1920-2015)
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.50326
N. Özhatay
{"title":"Professor Asuman Baytop (1920-2015)","authors":"N. Özhatay","doi":"10.16883/JFPIU.50326","DOIUrl":"https://doi.org/10.16883/JFPIU.50326","url":null,"abstract":"Former Head of the Department of Pharmaceutical Botany, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78766284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Β3-Adrenergic receptor (ADRB3) gene polymorphism with body mass index and bone mineral density in Turkish postmenopausal women 土耳其绝经后妇女Β3-Adrenergic受体(ADRB3)基因多态性与体重指数和骨密度的关系
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.15922
Özlem Kurt-Şirin, Hülya Yılmaz-Aydoğan Mehmet Uyar, M. Seyhan, T. Isbir, A. Can
{"title":"Association between Β3-Adrenergic receptor (ADRB3) gene polymorphism with body mass index and bone mineral density in Turkish postmenopausal women","authors":"Özlem Kurt-Şirin, Hülya Yılmaz-Aydoğan Mehmet Uyar, M. Seyhan, T. Isbir, A. Can","doi":"10.16883/JFPIU.15922","DOIUrl":"https://doi.org/10.16883/JFPIU.15922","url":null,"abstract":"Abstract: Previous studies have suggested that β3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral density (BMD). However, little is known concerning the effect of the ADRB3 gene on BMD. The present study investigated the relationship between ADRB3 Trp64Arg polymorphism, BMI and BMD in Turkish postmenopausal women. 133 postmenopausal women (81 osteoporotic and 52 healthy control) were recruited. For the detection of ADRB3 Trp64Arg polymorphism, polymerase chain reaction-restriction fragment lenght polymorphism (PCR-RFLP) techniques have been used. BMD was measured at the lumbar spine and hip by dual-energy X-ray absorptiometry. Distribution of ADRB3 Trp64Arg genotypes was similar in the study groups (p>0.05). “Arg/Arg” genotype was not observed. In the osteoporotic group, subjects with “Trp/Trp” genotype tended to have lower BMI values compared to those with “Trp/Arg” genotype, the difference was closely tied to statistical significance (p=0.052). Subjects with “Trp/Trp” genotype had also lower BMD values of femoral neck (p=0.044) and total hip (p=0.043) than those with “Trp/Arg” genotype. No significant effects of the ADRB3 Trp64Arg genotypes on BMI and BMD values were found in the control group. Our results suggested that ADRB3 Trp64Arg “Trp/Trp” genotype might be associated with osteoporosis risk by affecting body mass index and bone mineral density values in Turkish postmenopausal women. Key words: β3-adrenergic receptor, gene polymorphism, body mass index, bone mineral density, postmenopausal women","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73374083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A literature review of analytical methods used for identification and determination of counterfeit drugs 鉴别和测定假药所用分析方法的文献综述
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.52094
Vedat Oral, Sena Caglar Andac
{"title":"A literature review of analytical methods used for identification and determination of counterfeit drugs","authors":"Vedat Oral, Sena Caglar Andac","doi":"10.16883/JFPIU.52094","DOIUrl":"https://doi.org/10.16883/JFPIU.52094","url":null,"abstract":"Abstract: Drug counterfeiting is a serious problem in developed and developing countries. Different types of drugs are produced factitiously and endanger the health of the patients. Quick inspection methods for counterfeit drugs are of vital necessity. Since counterfeit drugs are becoming increasingly more sophisticated, additional analytical techniques are necessary to detect these counterfeits. Qualitative and quantitative analysis of pharmaceutical active ingredients could be achieved by chromatographic and spectroscopic methods. Various analytical techniques such as Liquid Chromatography/Mass Spectroscopy, Gas Chromatography/Mass Spectroscopy, Nuclear Magnetic Resonance and Raman/Infrared Spectroscopy are used to determine the counterfeit product. In this study, analytical methods used for identification and determination of counterfeit drugs were summarized. Keywords: Counterfeit drugs, chromatography, spectroscopy, analytical methods, drug determination, counterfeitin","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83834816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Oxidative stress mediated cardiac apoptosis 氧化应激介导的心脏凋亡
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.94532
M. Kara, E. Ozcagli, A. T. Jannuzzi, B. Alpertunga
{"title":"Oxidative stress mediated cardiac apoptosis","authors":"M. Kara, E. Ozcagli, A. T. Jannuzzi, B. Alpertunga","doi":"10.16883/JFPIU.94532","DOIUrl":"https://doi.org/10.16883/JFPIU.94532","url":null,"abstract":"Abstract: Cardiovascular diseases are one of the most common diseases all around the world. In both acute and chronic cardiac diseases, apoptosis is the primary pathway of disease nature and according to current studies apoptotic pathway inhibition has an important role in cardiac disease tretament procedures. There are several studies regarding clarification of molecular pathways of cardiac apoptosis in several heart diseases. Oxidative stress could be defined as imbalance between the antioxidant defense systems and high concentrations of reactive species that arose from cellular processes and this mechanism also initiates apoptosis in cardiac cells. In the pathogenesis of apoptosis mediated cardiac diseases, reactive oxygen species (ROS) are the main oxidative stress products that play an important role in complex signaling pathway as secondary messengers. Here, we  review  the current status of knowledge on ROS induced cardiac apoptosis in heart diseases. Key words: Cardiac apoptosis, oxidative stress, reactive oxygen species","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79269134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Comparative morphological and anatomical characteristics of the species known as lemongrass (limonotu): Melissa officinalis L., Cymbopogon citratus (DC) Stapf. and Aloysia citriodora Palau. 香茅属(limontu): Melissa officinalis L.、Cymbopogon citratus (DC) Stapf.的形态解剖学比较。和帕劳芦荟。
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI: 10.16883/JFPIU.86730
Y. Yeşil, E. Akalın
{"title":"Comparative morphological and anatomical characteristics of the species known as lemongrass (limonotu): Melissa officinalis L., Cymbopogon citratus (DC) Stapf. and Aloysia citriodora Palau.","authors":"Y. Yeşil, E. Akalın","doi":"10.16883/JFPIU.86730","DOIUrl":"https://doi.org/10.16883/JFPIU.86730","url":null,"abstract":"Abstract: Aloysia citriodora (Verbenaceae), Melissa officinalis (Lamiaceae) and Cymbopogon citratus (Poaceae) leaves have a gentle lemon-scented essential oil, contains citral or citronellal and are called the Lemongrass in Turkey. This similarity causes the use of plants for the same purposes despite the presence of different families and different morphological and anatomical structure. Instead of Melissa officinalis, which grows naturally in our country, Aloysia citriodora samples are sold in bazaars and herbal markets. Leaves of all species are used and sold. In this study morphological and anatomical features of leaves of Aloysia citriodora, Melissa officinalis and Cymbopogon citratus are investigated to identification of powder and big parts in herbal tea. Key words: Melissa, Cymbopogon, Aloysia, Lemongrass, Morphology, Anatomy.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73095946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Alteration in global DNA methylation after bisphenol a exposure in MCF-7 cells MCF-7细胞双酚a暴露后整体DNA甲基化的改变
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2014-09-01 DOI: 10.16883/JFPIU.49456
Mine Şenyıldız, S. Ozden
{"title":"Alteration in global DNA methylation after bisphenol a exposure in MCF-7 cells","authors":"Mine Şenyıldız, S. Ozden","doi":"10.16883/JFPIU.49456","DOIUrl":"https://doi.org/10.16883/JFPIU.49456","url":null,"abstract":"Abstract: Bisphenol A (BPA), as synthetic monomer used especially in the production of polycarbonate plastic and epoxy resins, has endocrine disruptor properties and high risk on human health. Continuous release of free BPA into food, beverages, and environment has resulted in a widespread human exposure to this chemical. Role of endocrine effects of environmental chemicals such as BPA on the changes in gene expression may be associated with epigenetic mechanisms. Early detection of aberrant DNA methylation, which regulates transcription of tumor suppressor genes and activation of oncogenes in carcinogenesis process, may provide powerful mechanistic insights in the toxicity of BPA. 5-hydroxymethylcytosine (5-hmC), oxidation product of 5-methylcytosine (5-mC), is considered as a new epigenetic DNA modification with relevant roles in cell homeostasis regulating DNA demethylation and transcription. Our aim was to investigate possible changes in the global 5-mC and 5-hmC after 48 and 96 h BPA exposure in mammalian breast cancer cell line (MCF-7). 50% of inhibitory concentration (IC50) value of BPA was determined as 148 μM by MTT cytotoxicity test in MCF-7 cells. We revealed decrease on the level of global 5-mC after BPA exposure (100 nM and 1 μM) for 48 and 96 h by using 5-mC Elisa kit, whereas non-significant slightly increase were observed in the levels of 5-hmC%. We suggested that global DNA methylation may be involved in BPA toxicity in breast cancer cells. Furthermore, evaluation on the expression of enzymes involved in DNA methylation and demethylation after BPA exposure should be investigated in cell cultures. Key words: Bisphenol A, 5-methylcytosine, 5-hydroxymethylcytosine, Cytotoxicity, MCF-7 cells.","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89304780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The melliferous plants of Apiaceae from Istanbul and their conservation importance 伊斯坦布尔蜂科蜜科植物及其保护意义
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2014-01-01 DOI: 10.16883/JFPIU.60016
M. Koçyi̇ği̇t
{"title":"The melliferous plants of Apiaceae from Istanbul and their conservation importance","authors":"M. Koçyi̇ği̇t","doi":"10.16883/JFPIU.60016","DOIUrl":"https://doi.org/10.16883/JFPIU.60016","url":null,"abstract":"Melliferous means bearing any substance that is collected by bees to produce honey. Honey properties are different due to floral sources. The major objectives of this project (The Platform of Bees) are to identify the plant sources used for the production of wildflower honey in Istanbul (Turkey) area. The assessment of their conservation status is an important part of the modern concept and practices of sustainable use of plant resources and conservation of plant diversity. Based on field observation, it was established that wild melliferous plants of the family Apiaceae in Istanbul flora are represented by 24 taxa belonging 19 genera. They represent about %10 of melliferous species of Istanbul flora","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73840381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Partial purification and some properties of aspartate aminotransferase from the mantle tissue of Mytilus galloprovincialis Lam. 紫贻贝(Mytilus galloprovincialis Lam)套膜组织中天冬氨酸转氨酶的部分纯化及其性质。
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2014-01-01 DOI: 10.16883/JFPIU.88283
Özlem Dönmez Yurtpınar
{"title":"Partial purification and some properties of aspartate aminotransferase from the mantle tissue of Mytilus galloprovincialis Lam.","authors":"Özlem Dönmez Yurtpınar","doi":"10.16883/JFPIU.88283","DOIUrl":"https://doi.org/10.16883/JFPIU.88283","url":null,"abstract":"Aspartate aminotransferase (E.C.2.6.1.1; AST), is a pyridoxal phosphate dependent enzyme that occurs in virtually all organisms and plays a key role in intermediary nitrogen metabolism. Although AST was purified from a variety of plant and animal sources, it has not been purified previously from mantle tissue of Mytilus galloprovincialis Lam. In the present study we have partially purified AST from the mantle tissue of M. galloprovincialis and investigated some kinetic properties of the enzyme. The partially purified enzyme showed three protein and a single activity band in polyacrylamide gel electrophoresis. It was found that the enzyme exhibited maximum activity at 15oC and 35oC and that the activity was decreased at 40oC and totally lost at 55oC. AST activity was maximum at pH 7.4 in Tris-HCl buffer. Km values of AST for aspartate and 2-oxoglutarate were 1.64 mM and 2.2x10-2 mM, respectively, and Vmax values for the same substrates were 0.12 U/mL and 0.168 U/mL, respectively","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79398271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Another first for the Apiaceae: evidence for mitochondrial DNA transfer into the plastid genome 蜜蜂科的另一个首次:线粒体DNA转移到质体基因组的证据
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2014-01-01 DOI: 10.16883/JFPIU.20070
S. R. Downie, R. Jansen
{"title":"Another first for the Apiaceae: evidence for mitochondrial DNA transfer into the plastid genome","authors":"S. R. Downie, R. Jansen","doi":"10.16883/JFPIU.20070","DOIUrl":"https://doi.org/10.16883/JFPIU.20070","url":null,"abstract":"The complete plastid genome (plastome) sequences of Anthriscus cerefolium, Crithmum maritimum, Hydrocotyle verticillata, Petroselinum crispum, and Tiedemannia filiformis subsp. greenmanii have recently been determined. With the exceptions of Crithmum and Petroselinum, which each demonstrate major shifts of their LSC-IRB (JLB) and LSC-IRA (JLA) junctions, all plastomes are typical of most other non-monocot angiosperm plastid DNAs in their structure, organization, and gene content. Crithmum and Petroselinum also incorporate novel DNA in the LSC region adjacent to Jsimilarity to any other region of their plastid genomes and BLAST searches of the Petroselinum insert resulted in multiple significant hits to angiosperm mitochondrial genome sequences. We highlight results of this recent work on the comparative analysis of whole plastid genomes from the Apiales, present the circular plastome gene map of Petroselinum crispum (parsley), review the literature indicating other instances of mitochondrial DNA transfer into Apiaceae plastomes as evidenced by complete mitochondrial DNA sequencing of Daucus carota, and describe our ongoing research on the elucidation of mechanisms creating the many large IR junction shifts characteristic of the family","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74921716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Anatomical, micromorphological and palynological studies on Turkish endemic Heracleum platytaenium Boiss. (Apiaceae) 土耳其特有种白棘球龙的解剖、显微形态和孢粉学研究。(伞形科)
Journal of Faculty Pharmacy of Istanbul University Pub Date : 2014-01-01 DOI: 10.16883/JFPIU.80221
Gülay Ecevit-Genç
{"title":"Anatomical, micromorphological and palynological studies on Turkish endemic Heracleum platytaenium Boiss. (Apiaceae)","authors":"Gülay Ecevit-Genç","doi":"10.16883/JFPIU.80221","DOIUrl":"https://doi.org/10.16883/JFPIU.80221","url":null,"abstract":"Heracleum platytaenium is monocarpic and strongly aromatic plant and differs from other species with stout stem, obovate-suborbicular mericarp. Fruits are dorsally compressed. In this study, the anatomical features of the mericarp, as well as micromorphological characteristics of the pollen, fruit and leaf of pollen H. platytaenium have been investigated. A distribution map of this species is also given. Flattened mericarps are with filiforme dorsal ribs, and wings. Four vittae are found in the both, dorsal and commissural sides. The fruit surfaces are reticulate and striate structure. The leaves surface are reticulate and rugose structure. Mericarp surfaces are hairy. The hair shape of fruit and leaf are ribbon-type. The pollen grains are prolate in shape and tricolporate aperture. The exine sculpturing of this species is rugulate. The plants are used as a folk medicinal herb and food","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86099805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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