{"title":"Xanomeline/Trospium Combination for Schizophrenia: Treatment Considerations for Older Adults.","authors":"Clayton English, Kaela Bergeron, Leigh Ann Mike","doi":"10.3928/00989134-20250509-03","DOIUrl":"10.3928/00989134-20250509-03","url":null,"abstract":"<p><strong>Purpose: </strong>Xanomeline/trospium, a combination of a mixed muscarinic agonist/peripheral antagonist, is a novel treatment for schizophrenia that does not antagonize dopamine receptors. Given its unique pharmacology on the cholinergic system, special considerations may apply for older adults.</p><p><strong>Method: </strong>The current article reviews the evidence of xanomeline/trospium in older adults as well as implications and considerations for use in practice.</p><p><strong>Results: </strong>The evidence of using xanomeline/trospium is largely derived from the phase-3 EMERGENT clinical trial program, which investigated safety and efficacy in adults aged 18 to 65 years with schizophrenia. Significant reduction in psychosis was demonstrated; however, gastrointestinal effects were common.</p><p><strong>Conclusion: </strong>Xanomeline/trospium is a novel treatment for schizophrenia that lacks many of the adverse effects associated with dopamine receptor blockers. Although the package insert provides guidance for use in older adults, patients aged >65 years were excluded from EMERGENT trials. Continued research is necessary to define the safety and place in therapy for older adults. [<i>Journal of Gerontological Nursing, 51</i>(6), 7-12.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":"51 6","pages":"7-12"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Li, Shuang Chen, Yilin Wang, Bei Wang, Jing Yuan, Wenkui Zheng, Yanling Li
{"title":"Chain Mediating Effect of Physical Activity and Psychological Resilience on Social Isolation and Psychological Well-Being in Community-Dwelling Older Adults.","authors":"Zheng Li, Shuang Chen, Yilin Wang, Bei Wang, Jing Yuan, Wenkui Zheng, Yanling Li","doi":"10.3928/00989134-20250324-01","DOIUrl":"10.3928/00989134-20250324-01","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the relationship between social isolation and psychological well-being among community-dwelling older adults and analyze the mediating role of physical activity and psychological resilience in the chain mediation effect between social isolation and psychological well-being.</p><p><strong>Method: </strong>Two hundred sixty-five older adults from six communities in Baoding City were selected using convenience sampling. Social isolation, physical activity, psychological resilience, and psychological well-being were measured. The SPSS PROCESS program was used to test the chain mediation effect.</p><p><strong>Results: </strong>Pearson correlation analysis indicated significant relationships between psychological well-being and social isolation, psychological resilience, and physical activity (all <i>p</i> < 0.001). Mediation analysis results showed that social isolation directly affects psychological well-being and influences psychological well-being through three mediation chains: physical activity, psychological resilience, and the chain mediation effect of physical activity and psychological resilience. Total mediation effect accounted for 60% of the total effect.</p><p><strong>Conclusion: </strong>Social isolation is a significant risk factor for decreased psychological well-being among older adults, and physical activity and psychological resilience serve as important explanatory mechanisms. Community health workers should prioritize the impact of social isolation on the psychological well-being of older adults and develop intervention strategies based on the pathways of physical activity and psychological resilience to enhance psychological well-being and promote healthy aging. [<i>Journal of Gerontological Nursing, 51</i>(6), 23-29.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"23-29"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Factors for Emergency Department Visits or Hospitalizations Among Older Adults With Urinary Incontinence in Home Health Care.","authors":"Danielle Scharp, Jiyoun Song, Mary Happel Palmer, Veronica Barcelona, Maxim Topaz","doi":"10.3928/00989134-20250417-02","DOIUrl":"10.3928/00989134-20250417-02","url":null,"abstract":"<p><strong>Purpose: </strong>To determine factors associated with emergency department (ED) visits or hospitalizations among older adults with urinary incontinence (UI) in home health care (HHC).</p><p><strong>Method: </strong>We analyzed HHC episode data for adults aged ≥65 years with UI. Five clusters were identified a priori using hierarchical clustering of symptoms extracted from clinical notes using natural language processing. Chi-square tests and backward stepwise logistic regression identified cluster, sociodemographic, and clinical variables associated with outcomes.</p><p><strong>Results: </strong>A total of 39,179 HHC episodes reflecting 29,981 patients were included. Episodes in the anxiety, all symptoms, dizziness-anxiety, and constipation-anxiety-dizziness clusters were more likely to result in ED visits/hospitalizations versus the no symptoms cluster. Episodes for Black and Hispanic patients had higher odds of these outcomes than White patients. Episodes for patients with skin ulcers and prior urinary tract infections had higher odds of these outcomes than those without these characteristics.</p><p><strong>Conclusion: </strong>Older adults with UI require comprehensive care addressing complex factors contributing to ED visits/hospitalizations. [<i>Journal of Gerontological Nursing, 51</i>(6), 38-47.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"38-47"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adverse Childhood Experiences Reported by Spouses of Persons Living With Dementia and Their Association With Care-Related Strain.","authors":"Kylee Deterding, Lyndsey Anderson, Allison Lindauer","doi":"10.3928/00989134-20250321-01","DOIUrl":"10.3928/00989134-20250321-01","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the association between adverse childhood experiences (ACEs) and care-related strain among spouses of persons living with dementia (PLWD).</p><p><strong>Method: </strong>Data from spouses (<i>N</i> = 30) of PLWD were included in a cross-sectional analysis examining whether childhood adversity, as measured by the Adverse Childhood Experiences Questionnaire (ACE-10), was associated with reports of care-related strain, as measured by the Zarit Burden Interview (ZBI-12).</p><p><strong>Results: </strong>Care-related strain was moderate (mean = 17), and there was a significant difference between ZBI-12 scores of spouses with no ACEs (<i>n</i> = 10, mean = 11.3) versus those with ≥1 ACE (<i>n</i> = 18, mean = 20.17) (<i>p</i> = 0.01, 95% confidence interval [-15.37, -2.36]). Multiple linear regression analysis indicated there was a significant association between ACE-10 and ZBI-12 scores (<i>p</i> = 0.006), even when controlling for role captivity (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>ACEs may influence the degree of care-related strain experienced by spouses of PLWD based on these preliminary results. Future research is needed to understand mechanisms and potential interventions for heightened appraisal of strain among spousal caregivers with ACEs. [<i>Journal of Gerontological Nursing, 51</i>(6), 17-21.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"17-21"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emika S Miller, Celia E Wills, Kimberly S Wilson-Lawson, Mary Beth Happ, Alai Tan, Todd B Monroe, Karen O Moss
{"title":"Perspectives of Former Caregivers of Black Older Adults Living With Dementia on Advance Care Planning.","authors":"Emika S Miller, Celia E Wills, Kimberly S Wilson-Lawson, Mary Beth Happ, Alai Tan, Todd B Monroe, Karen O Moss","doi":"10.3928/00989134-20250417-01","DOIUrl":"10.3928/00989134-20250417-01","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the perspectives of lower socioeconomic status (SES) former family caregivers of Black persons living with dementia (PLWD) on advance care planning needs and preferences for their care recipients.</p><p><strong>Method: </strong>Semi-structured interviews were completed with 17 lower SES former family caregivers of Black PLWD. Basic qualitative description was used for these analyses.</p><p><strong>Results: </strong>Four major themes were identified: (1) <i>Improvements Needed for Caregiver Education</i>, (2) <i>Caregiver Support Needs During and After Caregiving</i>, (3) <i>Obstacles Faced During Caregiving</i>, and (4) <i>Need for Restored Identity Following Care Recipient Death</i>. Former family caregivers also expressed a desire to support current caregivers.</p><p><strong>Conclusion: </strong>Findings fill a critical gap in the literature by highlighting challenges faced during and after caregiving. Future research should leverage perspectives of former caregivers to assist with improving outcomes for Black caregivers, thereby promoting health equity. [<i>Journal of Gerontological Nursing, 51</i>(6), 30-37.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"30-37"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frailty in Hospitalized Older Adults in the Rural Setting and Impact of Mobility on Length of Stay and Discharge Disposition.","authors":"Jessica B Buckner, Christine Sump","doi":"10.3928/00989134-20250401-01","DOIUrl":"10.3928/00989134-20250401-01","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence of frailty among individuals aged ≥65 years with heart failure and/or chronic obstructive pulmonary disease, and if there was a difference in length of stay (LOS) and/or discharge disposition in individuals who mobilized daily versus those who did not.</p><p><strong>Method: </strong>Thirty-five individuals were screened using the FRAIL Scale. A retrospective chart review was performed for participants with frailty, assessing residential location on admission and discharge, LOS, and daily mobilization during hospitalization.</p><p><strong>Results: </strong>Participants were categorized as robust (<i>n</i> = 1, 2.9%), pre-frail (<i>n</i> = 15, 42.9%), and frail (<i>n</i> = 19, 54.3%). Mean LOS for those who mobilized daily (<i>n</i> = 12) was 2.33 and 4.71 for those who did not mobilize daily (<i>p</i> = 0.028). A lower percentage of participants who mobilized (16.7%) required higher levels of care at discharge versus those who did not mobilize (42.9%, <i>p</i> = 0.067).</p><p><strong>Conclusion: </strong>Early recognition of frailty may provide opportunities to implement mobility programs to decrease LOS and ensure these individuals remain at functional baseline. [<i>Journal of Gerontological Nursing, 51</i>(6), 13-16.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"13-16"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges and Opportunities for Immigrant Nursing Staff in U.S. Long-Term Care Facilities.","authors":"Sherif Adewale Olanrewaju, Susan J Loeb","doi":"10.3928/00989134-20250414-01","DOIUrl":"https://doi.org/10.3928/00989134-20250414-01","url":null,"abstract":"","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":"51 5","pages":"4-6"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AGS' Recommendations to the CDC for Updating STEADI for Primary Care Published in <i>JAGS</i>.","authors":"Mark A Supiano","doi":"10.3928/00989134-20250326-02","DOIUrl":"https://doi.org/10.3928/00989134-20250326-02","url":null,"abstract":"","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":"51 5","pages":"55-56"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina B de Rosa, Ashleigh Holmes, Weijun Wang, Yu-Ping Chang
{"title":"The Association Between Caregiving Burden, the Caregiving Relationship, and Caregiver Health.","authors":"Cristina B de Rosa, Ashleigh Holmes, Weijun Wang, Yu-Ping Chang","doi":"10.3928/00989134-20250310-01","DOIUrl":"10.3928/00989134-20250310-01","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the mediating effects of the quality of family caregivers' relationships with their older adult care recipients on the association between care-giver burden and caregivers' mental health and perceived general health.</p><p><strong>Method: </strong>Participants included 2,431 family/informal caregivers from the 2022 National Study of Caregiving. Mediator path analysis models adjusting for caregivers' age, sex, and race/ethnicity were used to test the direct and indirect effects of caregiver burden on mental health and perceived general health via the caregiving relationship.</p><p><strong>Results: </strong>Quality of the caregiving relationship partially mediated the association between caregiver burden and mental health, and also partially mediated the association between caregiver burden and perceived general health.</p><p><strong>Conclusion: </strong>Caregiver burden and quality of the caregiving relationship are influential factors in caregiver health. Strategies addressing caregiver burden and the caregiving relationship simultaneously could yield potential benefits. [<i>Journal of Gerontological Nursing, 51</i>(5), 27-34.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"27-34"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Geriatric Care Competencies Among Nurses Working in Home Health Care in Saudi Arabia.","authors":"Samira Ahmed Alsenany, Amani A Alharbi","doi":"10.3928/00989134-20250311-01","DOIUrl":"10.3928/00989134-20250311-01","url":null,"abstract":"<p><strong>Purpose: </strong>To assess geriatric care competencies of nurses in home health care (HHC) settings in Saudi Arabia and explore the factors influencing these competencies.</p><p><strong>Method: </strong>A cross-sectional design was used. Data were collected using the Gerontological Nursing Competence Scale among 393 RNs working in HHC units in the Riyadh and Qassim regions.</p><p><strong>Results: </strong>Nurses demonstrated high competence in ensuring safe living environments and addressing nutritional needs. However, weaker competencies were noted in supporting older adults' sexuality and managing ethical challenges. Specialized training and shorter work hours were significantly associated with higher self-perceived competency levels. This finding may suggest that reduced working hours allows nurses to engage in continuing education, skill development, and quality-focused care, rather than indicating lack of clinical experience.</p><p><strong>Conclusion: </strong>Findings highlight strengths and gaps in geriatric care competencies among HHC nurses, emphasizing the need for targeted training to address weaknesses in sensitive areas, including sexual health, ethical dilemmas, and communication challenges in end-of-life care. [<i>Journal of Gerontological Nursing, 51</i>(5), 35-45.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":" ","pages":"35-45"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}