Journal of Functional Biomaterials最新文献_第4页

The Remineralizing and Desensitizing Potential of Hydroxyapatite in Dentistry: A Narrative Review of Recent Clinical Evidence. 羟基磷灰石在牙科中的再矿化和脱敏潜能：近期临床证据的叙述性回顾。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-09-04 DOI: 10.3390/jfb16090325

Jusef Naim, Sinan Sen

{"title":"The Remineralizing and Desensitizing Potential of Hydroxyapatite in Dentistry: A Narrative Review of Recent Clinical Evidence.","authors":"Jusef Naim, Sinan Sen","doi":"10.3390/jfb16090325","DOIUrl":"10.3390/jfb16090325","url":null,"abstract":"Although caries is declining in industrialized countries, early childhood caries and molar-incisor hypomineralization (MIH) remain clinically relevant. To meet the demand for effective and well-tolerated preventive strategies, hydroxyapatite (HAp) has gained attention as a biocompatible, fluoride-free agent. A structured narrative review was conducted to evaluate recent clinical evidence on the use of HAp. A PubMed search identified clinical trials from the past five years that investigated HAp-based products. Studies were included if they reported clinical outcomes related to remineralization, caries prevention, or desensitization. Fifteen clinical studies met the inclusion criteria. HAp seems to be a safe and effective alternative to flouride, especially for children or individuals at risk of overexposure. While both agents show similar efficacy in caries prevention, HAp may offer additional advantages in managing hypersensitivity and MIH. Compared to other remineralizing agents, such as calcium sodium phosphosilicate, HAp demonstrated comparable efficacy. Combination therapies show the most promising results. Future research should explore synergies of active ingredients and include standardized long-term studies to substantiate the clinical relevance of HAp.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Laser Scanning Parameters on Surface Morphology and Topography of Glass Solder-Coated Zirconia Substrate. 激光扫描参数对玻璃镀膜氧化锆基板表面形貌和形貌的影响。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-09-03 DOI: 10.3390/jfb16090324

Fiona Hartung, Christian Moss, Hermann Seitz, Georg Schnell

引用次数: 0

Enhanced Unidirectional Cell Migration Induced by Asymmetrical Micropatterns with Nanostructures. 纳米结构不对称微图案诱导细胞单向迁移增强。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-09-01 DOI: 10.3390/jfb16090323

Kaixin Chen, Yuanhao Xu, Stella W Pang

{"title":"Enhanced Unidirectional Cell Migration Induced by Asymmetrical Micropatterns with Nanostructures.","authors":"Kaixin Chen, Yuanhao Xu, Stella W Pang","doi":"10.3390/jfb16090323","DOIUrl":"10.3390/jfb16090323","url":null,"abstract":"Directed cell migration is crucial for numerous biological processes, including tissue regeneration and cancer metastasis. However, conventional symmetrical micropatterns typically result in bidirectional cell migration guidance instead of unidirectional guidance. In this study, polydimethylsiloxane (PDMS)-based platforms with asymmetrical arrowhead micropatterns, nanopillars, and selective fibronectin coating were developed to enhance unidirectional cell migration. The platforms were fabricated using nanoimprint lithography and PDMS replication techniques, allowing for precise control over surface topography and biochemical modification. The MC3T3 osteoblastic cells cultured on these platforms demonstrated significantly enhanced directional migration, characterized by increased displacement, and directional alignment with micropattern orientation compared to symmetrical patterns. Quantitative analyses revealed that asymmetrical arrowheads combined with nanopillars induced more focal adhesions and F-actin polarization at cell front regions, supporting the observed unidirectional cell migration enhancement. These results confirm that integrating micropattern asymmetry, nanoscale features, and biochemical functionalization synergistically promotes unidirectional cell migration. The developed platforms offer valuable insights and practical strategies for designing advanced biomaterials capable of precise spatial cell guidance that can be applied to the designs of organ-on-a-chip systems.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Histological and Clinical Evaluation of Long-Term Outcomes of Bovine Bone-Derived Xenografts in Oral Surgery: A Systematic Review. 口腔手术中牛骨来源异种移植物长期疗效的组织学和临床评价：一项系统综述。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-09-01 DOI: 10.3390/jfb16090321

Angelo Michele Inchingolo, Grazia Marinelli, Irma Trilli, Gaetano Del Vecchio, Angela Di Noia, Francesco Inchingolo, Massimo Del Fabbro, Andrea Palermo, Alessio Danilo Inchingolo, Gianna Dipalma

{"title":"A Histological and Clinical Evaluation of Long-Term Outcomes of Bovine Bone-Derived Xenografts in Oral Surgery: A Systematic Review.","authors":"Angelo Michele Inchingolo, Grazia Marinelli, Irma Trilli, Gaetano Del Vecchio, Angela Di Noia, Francesco Inchingolo, Massimo Del Fabbro, Andrea Palermo, Alessio Danilo Inchingolo, Gianna Dipalma","doi":"10.3390/jfb16090321","DOIUrl":"10.3390/jfb16090321","url":null,"abstract":"Background: Bovine bone-derived xenografts are widely used in regenerative dental procedures due to their osteoconductive properties and volumetric stability. However, their long-term behavior and biological integration remain a subject of debate. This systematic review aims to critically assess the histological and clinical outcomes associated with bovine xenografts over extended follow-up periods.Methods: An electronic search was performed in PubMed, Scopus, and Web of Science, including studies published in the English language from 2005 to 2025 for a total of 217 records, which were initially identified from PubMed, Scopus, and Wos.Results: After duplicate removal, following title/abstract screening and full-text evaluation, 11 studies met the inclusion criteria. These studies reported on the use of bovine-derived xenografts in clinical contexts, assessing parameters such as graft integration, histological remodeling, complication incidence (e.g., chronic inflammation or foreign body reactions), and implant success rates over time.Conclusions: The current evidence suggests that bovine-derived xenografts, particularly Bio-Oss®, are associated with favorable long-term outcomes in bone regenerative procedures, demonstrating satisfactory graft integration and implant survival rates. However, variations in study design, follow-up duration, and outcome measures warrant further high-quality, long-term randomized clinical trials to confirm these findings and guide clinical decision-making.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adhesion and Colonization Intensity of Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans on Smooth, Micro-Textured, and Macro-Textured Silicone Biomaterials. 表皮葡萄球菌、铜绿假单胞菌和白色念珠菌在光滑、微纹理和宏观纹理有机硅生物材料上的粘附和定植强度

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-09-01 DOI: 10.3390/jfb16090322

Kirils Jurševičs, Ingus Skadiņš, Jeļena Krasiļņikova, Anna Lece, Andrejs Šķesters, Eduards Jurševičs

{"title":"Adhesion and Colonization Intensity of Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans on Smooth, Micro-Textured, and Macro-Textured Silicone Biomaterials.","authors":"Kirils Jurševičs, Ingus Skadiņš, Jeļena Krasiļņikova, Anna Lece, Andrejs Šķesters, Eduards Jurševičs","doi":"10.3390/jfb16090322","DOIUrl":"10.3390/jfb16090322","url":null,"abstract":"Implantable biomaterials are widely used in modern medicine, especially in orthopaedics, cardiovascular surgery, dentistry, and plastic and reconstructive surgery. The issue of the interaction of implants with body tissues and the risk of infection associated with them is one of the most studied and topical issues in medicine. It is very important to find a biomaterial that effectively combines both microbiology and tissue compatibility aspects. The aim of this research work was to determine the adhesion and colonization rates of Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans on smooth, microtextured, and macro-textured silicone biomaterials in an in vitro study. A total of 90 silicone biomaterial samples were used, 30 for each type of biomaterial. In each of the biomaterial groups, half of the samples (n = 15) were used to determine the adhesion intensity and the other half to determine the colonization intensity on the active surface of the biomaterial samples. The study found that Staphylococcus epidermidis and Pseudomonas aeruginosa had the highest adhesion intensity on the macro-textured implant, while Candida albicans adhered best to smooth. Among the microorganisms, Pseudomonas aeruginosa demonstrated the highest colonization rate, followed by Staphylococcus epidermidis and then Candida albicans. The most intensive colonization of microorganisms was on the macro-textured implant, then on the micro-textured, and then on the smooth. The smooth and micro-textured implants did not show statistically significant differences in the intensity of adhesion and colonization. The biomaterials did not show pro-oxidant or anti-oxidant properties, and no lipid peroxidation was induced by the biomaterials.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Resin Cement Color Stability and Restoration Thickness as Determinants of the Final Shade in a Glass-Ceramic CAD/CAM Material. 生物活性树脂水泥颜色稳定性和修复厚度是玻璃陶瓷CAD/CAM材料最终色度的决定因素。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-08-31 DOI: 10.3390/jfb16090319

Hanin E Yeslam, Alaa Turkistani

{"title":"Bioactive Resin Cement Color Stability and Restoration Thickness as Determinants of the Final Shade in a Glass-Ceramic CAD/CAM Material.","authors":"Hanin E Yeslam, Alaa Turkistani","doi":"10.3390/jfb16090319","DOIUrl":"10.3390/jfb16090319","url":null,"abstract":"Bioactive resin cements are gaining popularity for their clinical benefits, but concerns remain regarding their color stability. This study evaluated the color change (ΔE00) and whiteness change (ΔWID) in bioactive resin cements and how their potential discoloration affects the shade of bonded CAD/CAM glass-ceramics at different ceramic thicknesses. VITA Mark II blocks were prepared in three thicknesses (0.5, 0.8, and 1.0 mm) and divided by resin cement: Panavia SA Universal (Pn), Predicta Bioactive Cement (Pr), and ACTIVA BioACTIVE Cement (Ac) (n = 10). Additionally, 10 specimens (10 × 2 mm) of each cement alone were prepared. Color was measured before and after 24 days of coffee immersion. Cement type significantly affected ΔE00 (p < 0.001). Pn had the highest color stability, followed by Pr and Ac, with significant differences between each. ΔWID also varied by cement (p = 0.004), with Pn and Pr differing significantly from Ac. Ceramic thickness alone had no significant effect on ΔE00 or ΔWID, but its interaction with cement type was significant (p < 0.001). While ceramic thickness does not directly affect the final shade, its combination with resin cement does. Choosing the right resin cement is key for long-term esthetic outcomes.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiofilm Activity of a Novel Calcium Phosphate Cement Doped with Two Antibiotics. 掺两种抗生素的新型磷酸钙水泥抗生物膜活性研究。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-08-31 DOI: 10.3390/jfb16090320

Eneko Elezgaray, Cassandra Pouget, Fanny Salmeron, Catherine Flacard, Jean-Philippe Lavigne, Vincent Cavaillès, Mikhael Bechelany

{"title":"Antibiofilm Activity of a Novel Calcium Phosphate Cement Doped with Two Antibiotics.","authors":"Eneko Elezgaray, Cassandra Pouget, Fanny Salmeron, Catherine Flacard, Jean-Philippe Lavigne, Vincent Cavaillès, Mikhael Bechelany","doi":"10.3390/jfb16090320","DOIUrl":"10.3390/jfb16090320","url":null,"abstract":"This study presents the development of a degradable and biocompatible calcium phosphate cement (CPC) co-loaded with gentamicin (1.25 wt%) and vancomycin (4.25 wt%) for the local treatment of polymicrobial bone infections. The antibiotics were incorporated-individually or in combination-into the solid phase of Graftys® Quickset (GQS), an injectable CPC. Antibiotic loading modifies some of the intrinsic properties of the GQS cement. Porosity exceeded 53%, compressive strength reduced around 5 MPa, which is comparable to calcium sulphates cements, and the setting time, although extended, remained within the clinically acceptable threshold (<20 min), ensuring suitable handling. A burst release of both antibiotics was observed within the first 24 h, with sustained release over time and no cytotoxic effects on human osteoblasts. The dual-loaded cement exhibited broad-spectrum antibacterial activity against both Gram-positive and Gram-negative strains, including methicillin-resistant isolates, in both planktonic and biofilm forms. Notably, the combination of both antibiotics demonstrated superior efficacy compared to either antibiotic alone. These findings suggest that this dual-antibiotic-loaded CPC offers a promising strategy for localised treatment of complex bone infections such as osteomyelitis, where polymicrobial involvement and antibiotic resistance pose significant therapeutic challenges.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nature-Based Hydrogels Combined with Nanoparticles for Bone Regeneration. 基于自然的水凝胶结合纳米颗粒用于骨再生。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-08-30 DOI: 10.3390/jfb16090317

Margarida Fernandes, Mónica Vieira, Daniela Peixoto, Natália M Alves

引用次数: 0

Innovative Smart Materials in Restorative Dentistry. 牙科修复中的创新智能材料。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-08-30 DOI: 10.3390/jfb16090318

Roxana Ionela Vasluianu, Livia Bobu, Iulian-Costin Lupu, Magda Antohe, Bogdan Petru Bulancea, Antonia Moldovanu, Ovidiu Stamatin, Catalina Cioloca Holban, Ana Maria Dima

{"title":"Innovative Smart Materials in Restorative Dentistry.","authors":"Roxana Ionela Vasluianu, Livia Bobu, Iulian-Costin Lupu, Magda Antohe, Bogdan Petru Bulancea, Antonia Moldovanu, Ovidiu Stamatin, Catalina Cioloca Holban, Ana Maria Dima","doi":"10.3390/jfb16090318","DOIUrl":"10.3390/jfb16090318","url":null,"abstract":"The growing challenge of biofilm-associated infections in dentistry necessitates advanced solutions. This review highlights the potential of smart bioactive and antibacterial materials-bioactive glass ceramics (BGCs), silver nanoparticle (AgNP)-doped polymers, and pH-responsive chitosan coatings-in transforming restorative dentistry. BGCs reduce biofilms by >90% while promoting bone integration. AgNP-polymers effectively combat S. mutans and C. albicans but require controlled dosing (<0.3 wt% in PMMA) to avoid cytotoxicity. Chitosan coatings enable pH-triggered drug release, disrupting acidic biofilms. Emerging innovations like quaternary ammonium compounds, graphene oxide hybrids, and 4D-printed hydrogels offer on-demand antimicrobial and regenerative functions. However, clinical translation depends on addressing cytotoxicity, standardizing antibiofilm testing (≥3-log CFU/mL reduction), and ensuring long-term efficacy. These smart materials pave the way for self-defending restorations, merging infection control with tissue regeneration. Future advancements may integrate AI-driven design for multifunctional, immunomodulatory dental solutions.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects. 可生物降解金属支架：进展、挑战和前景。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-08-29 DOI: 10.3390/jfb16090315

Lifeng Sun, Yuanyuan Zeng, Zhengyu Shen, Chongsheng Yue, Yahan Yang, Jia Gao, Junhao Zhang, Qi Yuan, Limei Cha

{"title":"Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects.","authors":"Lifeng Sun, Yuanyuan Zeng, Zhengyu Shen, Chongsheng Yue, Yahan Yang, Jia Gao, Junhao Zhang, Qi Yuan, Limei Cha","doi":"10.3390/jfb16090315","DOIUrl":"10.3390/jfb16090315","url":null,"abstract":"Cardiovascular disease is a leading cause of global mortality. Percutaneous coronary intervention, which involves the placement of stents to restore blood flow in narrowed arteries, is a widely used treatment. However, traditional stents, such as bare metal stents and drug-eluting stents, can lead to long-term complications such as restenosis, inflammation, and thrombosis. Biodegradable metallic vascular stents, with their superior mechanical properties, excellent biocompatibility, and gradual degradation in vivo, hold significant potential for the treatment of coronary artery disease. This review provides a comprehensive overview of the current research status and challenges. Firstly, it outlines the design principles and performance evaluation methods for biodegradable stents, which focus on mechanical properties, chemical characteristics, corrosion behavior, and biocompatibility. Furthermore, it summarizes the material features, degradation mechanisms, and metabolic behavior of three primary biodegradable metals-magnesium alloys, iron alloys, and zinc alloys-and discusses critical issues such as the degradation rate of different alloys and the development of zinc alloys. Finally, based on the current achievements and challenges of studies on biodegradable metal-based stents, this article proposes some optimization strategies and research prospects.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 9","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12470573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0