Journal of ethnopharmacology最新文献

{"title":"Corrigendum to \"Chrysin reprograms microglial metabolism and function via targeting SYK to alleviate the symptoms of Alzheimer's disease\" [J. Ethnopharmacol. (2026) 122056].","authors":"Lixi Li, Yanjia Gu, Xinyue Luo, Jinyu Wang, Ying Jia, Tingxu Yan","doi":"10.1016/j.jep.2026.122169","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122169","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122169"},"PeriodicalIF":6.8,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Maimendong decoction modulates the PINK1/Parkin signaling pathway alleviates type 2 alveolar epithelial cells senescence and enhances mitochondrial autophagy to offer potential therapeutic effects for idiopathic pulmonary fibrosis\" [J. Ethnopharmacol., 345, (9 April 2025), 119568].","authors":"Yuhe Zhou, Wen Su, Mengzhen Xu, Aijun Zhang, Shaoli Li, Hong Guo, Kai Gong, Kaihui Lu, Xin Yu, Jiang Zhu, Qingjun Zhu, Chuanguo Liu","doi":"10.1016/j.jep.2026.122158","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122158","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122158"},"PeriodicalIF":6.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition\" [J. Ethnopharmacol. 349 (2025) 119965].","authors":"Shishuang Yu, Ke Liu, Fengjiao Zhou, Xiuli Yang, Junru Zhang, Kexin Yu, Yi Zhu, Ling Qin, Ting Peng, Chuantao Zhang, Yujiao He","doi":"10.1016/j.jep.2026.122127","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122127","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122127"},"PeriodicalIF":6.8,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Codonopsis pilosula (Dangshen) decoction promotes NR2F2-dependent pulmonary endothelial repair in an H9N2-induced lung injury model\" [J. Ethnopharmacol. 370 (2026) 122078].","authors":"Qian Ye, Zhenyi Liu, Yuanyuan Zhang, Chang Qiao, Haotong Guo, Yan Zhi, Chaohui Zhang, Ge Hu, Tao Zhang, Youran Wu, Qian Zhang","doi":"10.1016/j.jep.2026.122151","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122151","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122151"},"PeriodicalIF":6.8,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Study of the acute and subacute toxicity of alkaloids from Tetraena gaetula\" [J. Ethnopharmacol. 368 (2026) 121808].","authors":"Omaima Boudaia, Zineb Sekkout, Najat El Amrani, Driss Radallah, Amal El Hamsas El Youbi","doi":"10.1016/j.jep.2026.122110","DOIUrl":"10.1016/j.jep.2026.122110","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122110"},"PeriodicalIF":6.8,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Shengxian decoction mitigate bleomycin-induced pulmonary fibrosis in mice via MerTK mediated macrophage efferocytosis\" [J. Ethnopharmacol. 365 (2026) 121583].","authors":"Pengxiang Zhao, Yaning Liu, Shanyao Liu, Le Li, Huan Song, Guojing Zhao, Ying Sun, Guohu Di, Xuechao Lu, Haibo Hu","doi":"10.1016/j.jep.2026.122114","DOIUrl":"10.1016/j.jep.2026.122114","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122114"},"PeriodicalIF":6.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive improvement and hippocampal BDNF/GFAP alterations by Schinus molle essential oil in a rat model of scopolamine-induced amnesia","authors":"Umut İrfan Üçel ,&nbsp;Ümmühan Kandemi̇r ,&nbsp;Cevşen Yazici ,&nbsp;Öznur Bi̇lgi̇n ,&nbsp;Nazlı Turan Yücel ,&nbsp;Temel Özek ,&nbsp;Ümide Demi̇r Özkay ,&nbsp;Gökalp İşcan ,&nbsp;Özgür Devrim Can","doi":"10.1016/j.jep.2026.121309","DOIUrl":"10.1016/j.jep.2026.121309","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div><em>Schinus molle</em> L. (Anacardiaceae) has been traditionally used for conditions related to the nervous system and emotional well-being, often through aromatic preparations. However, its cognition-specific effects have not yet been investigated.</div></div><div><h3>Aim of the study</h3><div>To assess the cognitive effects of the fruit-derived essential oil of <em>Schinus molle</em> L. (SMEO), administered via oral and inhalation routes, in a rat model of scopolamine-induced amnesia.</div></div><div><h3>Materials and methods</h3><div>SMEO was obtained by hydrodistillation and characterised by GC–MS/GC–FID. Amnesic rats received SMEO for 14 days by inhalation (1% or 3%) or oral gavage (100 or 200 mg/kg). Cognition was assessed by Morris water maze (MWM), passive avoidance (PA), and novel object recognition (NOR) tests; locomotion was measured by activity-meter. Hippocampal BDNF and GFAP immunoreactivity were assessed by immunohistochemistry.</div></div><div><h3>Results</h3><div>SMEO was dominated by α-phellandrene (48.7%). Scopolamine impaired cognition, whereas SMEO attenuated deficits with efficacy comparable to piracetam. Key behavioural and immunohistochemical findings (main omnibus statistical effects) were as follows: In the MWM, treatment and time effects on escape latency were significant (both p &lt; 0.001), and probe performance improved (p &lt; 0.001). PA retention was restored (p &lt; 0.001) and the NOR index improved (p &lt; 0.001), without locomotor changes (all p &gt; 0.05). Scopolamine reduced hippocampal BDNF immunoreactivity in CA1 and DG (p &lt; 0.01) and CA3 (p &lt; 0.001), which was restored by SMEO via both routes. GFAP immunoreactivity was reduced in CA1/CA3/DG (all p &lt; 0.001) and was rescued selectively after inhalation.</div></div><div><h3>Conclusions</h3><div>These findings provide preclinical evidence consistent with an ethnopharmacological rationale for SMEO and support further translational work to clarify its relevance beyond this experimental paradigm.</div></div>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":"362 ","pages":"Article 121309"},"PeriodicalIF":5.4,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid antidepressant effects of Aurantii Fructus are mediated by hypoxanthine-caspase-4 axis in CUMS mice","authors":"Chao Lu,&nbsp;Liyuan Tian,&nbsp;Zixuan Wei,&nbsp;Yiran Jiang,&nbsp;Mengqi Shao,&nbsp;Yaping Zhu,&nbsp;Lei Wu","doi":"10.1016/j.jep.2026.121330","DOIUrl":"10.1016/j.jep.2026.121330","url":null,"abstract":"<div><h3>Ethnopharmacological relevancy</h3><div>Aurantii Fructus (AF)is a traditional Chinese medicine historically used to regulate Qi and alleviate emotional distress, suggesting potential psychotropic effects. This study investigates its therapeutic value for depression based on this traditional indication.</div></div><div><h3>Aim of the study</h3><div>To evaluate the rapid antidepressant-like effect of a single acute dose of AF extract in a chronic unpredictable mild stress (CUMS) mouse model and elucidate its underlying molecular mechanisms through integrated transcriptomic and metabolomic analyses.</div></div><div><h3>Materials and methods</h3><div>AF flavonoid content was quantified by HPLC. Male mice underwent a 4-week CUMS protocol. A single oral dose of AF was administered 2 h prior to behavioral testing (NSF, TST, SPT, and OFT), with ketamine serving as a positive control. Hippocampal transcriptome analysis was performed by RNA sequencing, and serum metabolites were profiled via LC-MS in both positive and negative ion modes. Pearson correlation analysis assessed relationships between key targets and behavioral outcomes. Pathway involvement was functionally validated in a separate experiment using a hypoxanthine synthesis inhibitor.</div></div><div><h3>Results</h3><div>AF contained narirutin (1.32 mg/g), hesperidin (3.19 mg/g), neohesperidin (22.89 mg/g), naringenin (0.03 mg/g), and nobiletin (0.08 mg/g). Acute AF administration rapidly reversed CUMS-induced depressive-like behaviors, significantly decreasing latency to feed and increasing food consumption in the NSF test, reducing immobility time in the TST, and elevating sucrose preference in the SPT, without altering locomotor activity. Transcriptomic analysis revealed specific downregulation of hippocampal caspase-4 expression by AF. Metabolomic profiling showed AF normalized elevated serum hypoxanthine levels. Serum hypoxanthine levels negatively correlated with hippocampal caspase-4 expression and behavioral improvements, whereas caspase-4 expression positively correlated with behavioral deficits. Pharmacological inhibition of hypoxanthine synthesis abolished AF's antidepressant effects and prevented its normalization of hippocampal caspase-4, NF-κB, GDNF, and BDNF expression.</div></div><div><h3>Conclusions</h3><div>Acute AF produces rapid, ketamine-like antidepressant effects by targeting the hypoxanthine-caspase-4 pathway. This study reveals a novel purinergic mechanism underlying AF's traditional use for emotional disorders and offers a promising therapeutic strategy for rapid-acting antidepressant development.</div></div>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":"362 ","pages":"Article 121330"},"PeriodicalIF":5.4,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gancao decoction ameliorated senecionine-induced Hepatic Sinusoidal Obstruction Syndrome in mice by inhibiting NET formation and senecionine bioactivation in liver","authors":"Shuang Zhang ,&nbsp;Dongming Yan ,&nbsp;Si Cheng ,&nbsp;Jingyi Jin ,&nbsp;Jiamin Cui ,&nbsp;Chenghai Liu ,&nbsp;Yue Li ,&nbsp;Furong Qiu","doi":"10.1016/j.jep.2026.121356","DOIUrl":"10.1016/j.jep.2026.121356","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div>In China, pyrrolizidine alkaloid (PA)-induced hepatic sinusoidal obstruction syndrome (HSOS) accounts for approximately 50.0-88.6% of all HSOS cases, primarily resulting from inadvertent ingestion of <em>Gynura japonica</em> (Thunb.) Juel. (Tǔ sān qī). <em>Glycyrrhiza uralensis</em> Fisch. (Gān cǎo), a classical hepatoprotective herb in Traditional Chinese Medicine (TCM), has recently demonstrated significant protective effects against PA-induced HSOS in murine models. However, its underlying mechanisms remain poorly understood.</div></div><div><h3>Aim of study</h3><div>This study aimed to assess the therapeutic efficacy of Gancao decoction (GCD) and elucidate its underlying mechanisms in PA-induced HSOS.</div></div><div><h3>Materials and methods</h3><div>HSOS was induced in mice by senecionine (SEN), followed by treatment with GCD or enoxaparin (ENO, positive control). Histopathological and therapeutic efficacy was assessed by histopathological examination and serum biochemical analyses. Neutrophil depletion was employed to investigate the contribution of neutrophil extracellular traps (NETs) to the protective effects of GCD. Transcriptomic analysis was performed to identify potential targets of GCD. Mechanistic studies were investigated using quantitative real-time PCR (qPCR), Western blotting (WB), and immunofluorescence (IF). In addition, the inhibitory effect of GCD on SEN bioactivation was evaluated using human liver microsomes (HLMs).</div></div><div><h3>Results</h3><div>GCD improved serum biochemistry and hepatic histopathology in SEN-induced HSOS mice. Mechanistically, GCD suppressed intrahepatic neutrophil chemotaxis, thereby reducing NET formation and alleviating immunothrombosis. Furthermore, GCD inhibited the hepatic formation of dehydropyrrolizidine (DHP), the reactive metabolite responsible for SEN-induced HSOS.</div></div><div><h3>Conclusion</h3><div>GCD attenuated SEN-induced HSOS through dual mechanisms: (1) suppression of chemokine-driven neutrophil chemotaxis, leading to reduced NET formation and immunothrombosis; (2) inhibiting of SEN bioactivation. These findings provide mechanistic support for the ethnopharmacological use of Gancao in PA-HSOS and highlight its potential for clinical translation.</div></div>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":"362 ","pages":"Article 121356"},"PeriodicalIF":5.4,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomics and metabolomics demonstrate that Taohe Chengqi decoction alleviates sepsis-associated acute lung injury by modulating immunometabolism","authors":"Zuming Li ,&nbsp;Jiankun Chen ,&nbsp;Ming Gao ,&nbsp;Kao Gan ,&nbsp;Jian Xu ,&nbsp;Wanhua Huo ,&nbsp;Simin Pan ,&nbsp;Yunqi Kong ,&nbsp;Xiaoya Li ,&nbsp;Jiqiang Li ,&nbsp;Yue Lu ,&nbsp;Yuntao Liu ,&nbsp;Rongyuan Yang","doi":"10.1016/j.jep.2026.121283","DOIUrl":"10.1016/j.jep.2026.121283","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div>The clinical treatment of sepsis-associated acute lung injury (SA-ALI) is a major issue faced by critical care medicine. Taohe Chengqi decoction (THCQ), a formulation rooted in traditional Chinese medicine, exhibits potential therapeutic efficacy in the management of sepsis-associated complications. However, the precise mechanisms underlying its effects remain to be comprehensively elucidated.</div></div><div><h3>Aim of the study</h3><div>This study aimed to explore the potential immunometabolism mechanisms of THCQ in the treatment of SA-ALI.</div></div><div><h3>Materials and methods</h3><div>The study first established an LPS-induced SA-ALI mouse model to verify the pharmacological effects of THCQ. Non-targeted metabolomics was employed to explore the metabolic pathways regulated by THCQ, including OPLS-DA, differential metabolites, and pathway enrichment. Single-cell transcriptomics was employed to investigate the immune microenvironment regulated by THCQ, including gene expression analysis, pathway enrichment, and cellular communication. Finally, the pharmacological mechanism of THCQ was validated by Western blotting, RT-PCR, ELISA, and flow cytometry.</div></div><div><h3>Results</h3><div>Integrating single-cell transcriptomics and untargeted metabolomics analysis revealed that THCQ improved the alveolar-capillary barrier by inhibiting glycolysis. Specifically, THCQ ameliorated pathological changes in alveolar epithelial cells and microvascular endothelial cells, and inhibited the pro-inflammatory response of damage-responsive alveolar fibroblasts. THCQ reversed the pathological mechanism of Il1b⁺alveolar macrophages and NK cells by regulating glycolysis, and demonstrated the potential to regulate the phenotype of Fth1⁺neutrophils and Prok2⁺neutrophils, reshaping the immune microenvironment during SA-ALI.</div></div><div><h3>Conclusion</h3><div>This study reveals the immunometabolism mechanism of THCQ treatment for SA-ALI through single-cell transcriptomics and metabolomics analysis, laying the groundwork for subsequent fundamental research and clinical applications. These findings are based on one batch of THCQ, so further studies are necessary to confirm consistent effects across multiple batches for reproducibility and clinical relevance.</div></div>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":"362 ","pages":"Article 121283"},"PeriodicalIF":5.4,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}