Journal of Exposure Science and Environmental Epidemiology最新文献

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Young infants' exposure to parabens: lotion use as a potential source of exposure. 婴儿对羟基苯甲酸酯的接触:洗剂的使用是潜在的接触源。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-02-15 DOI: 10.1038/s41370-025-00756-4
Elizabeth Boxer, Yilin Zhong, Jessica Levasseur, Heather M Stapleton, Kate Hoffman
{"title":"Young infants' exposure to parabens: lotion use as a potential source of exposure.","authors":"Elizabeth Boxer, Yilin Zhong, Jessica Levasseur, Heather M Stapleton, Kate Hoffman","doi":"10.1038/s41370-025-00756-4","DOIUrl":"https://doi.org/10.1038/s41370-025-00756-4","url":null,"abstract":"<p><strong>Background: </strong>Parabens are widely used as antimicrobials in personal care products and pharmaceuticals. While previous studies demonstrate paraben exposure is ubiquitous, data investigating infants' exposure is limited.</p><p><strong>Objective: </strong>We sought to characterize infants' exposure to parabens and identify factors associated with higher levels of exposure.</p><p><strong>Methods: </strong>Families enrolled in the CHildren's Immune ResPonse Study between 2016-2018. Parents completed questionnaires, providing information on demographics and lifestyle factors. Urine samples were collected when infants were 1 to 3 months old (n = 71) and 12 months old (n = 29), with 18 infants evaluated at both ages. Parabens were measured in urine samples using liquid chromatography tandem mass spectrometry and served as an indicator of exposure.</p><p><strong>Results: </strong>Methylparaben (MP), ethylparaben (EP), and propylparaben (PP) were detected in >70% of urine samples, and concentrations ranged several orders of magnitude (specific-gravity-corrected medians: MP = 25.4 PP = 3.55; EP = 0.90 ng/mL). Butylparaben was detected less frequently (<50%). Paraben concentrations were lower than those reported for older children and adults; however, we did not find statistically significant differences in paraben concentrations by infant age. Correlations between measurements taken over time were poor, suggesting paraben exposure is variable, and multiple measurements are needed to capture cumulative exposure information. We observed differences in exposure by race/ethnicity and socioeconomic status; non-White infants and infants whose parents completed less education had higher paraben exposure. Recent lotion usage strongly predicted paraben exposure in 1-3-month-olds. For example, infants using lotion in the past seven days had urinary MP concentrations 355% higher than infants without lotion usage (e<sup>ß</sup> = 4.55, 95% Confidence Interval = 1.68, 12.55, p < 0.001). Together, our results suggest infants are ubiquitously exposed to parabens and personal care product use may be an important source of exposure.</p><p><strong>Impact: </strong>To the best of our knowledge, this is the first paper to report paraben levels and evaluate predictors of exposure in infants. This study supports the hypothesis that universal exposure to parabens extends to infants, as indicated by urinary biomarker concentrations. Of the predictors evaluated, lotion use in the last seven days was the strongest predictor of exposure in 1-3-month-olds. Given infant paraben levels are strongly correlated to lotion use, there may be an opportunity for parents to reduce paraben exposure by limiting its application or consulting ingredient labels to ensure no parabens are present.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noise: a public health problem 噪音:一个公共健康问题。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-02-11 DOI: 10.1038/s41370-025-00748-4
Jamie L. Banks, Elaine A. Cohen Hubal
{"title":"Noise: a public health problem","authors":"Jamie L. Banks,&nbsp;Elaine A. Cohen Hubal","doi":"10.1038/s41370-025-00748-4","DOIUrl":"10.1038/s41370-025-00748-4","url":null,"abstract":"","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 1","pages":"1-2"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41370-025-00748-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mass and particle size distribution of household dust on children's hands. 儿童手上的家庭灰尘的质量和粒度分布。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-02-10 DOI: 10.1038/s41370-025-00749-3
Cristina Fayad-Martinez, Maribeth Gidley, Matthew A Roca, Ryuichi Nitta, Ali Pourmand, Arash Sharifi, Foluke Adelabu, Jenna K Honan, Olusola Olabisi Ogunseye, Paloma I Beamer, Helena Solo-Gabriele, Alesia Ferguson
{"title":"Mass and particle size distribution of household dust on children's hands.","authors":"Cristina Fayad-Martinez, Maribeth Gidley, Matthew A Roca, Ryuichi Nitta, Ali Pourmand, Arash Sharifi, Foluke Adelabu, Jenna K Honan, Olusola Olabisi Ogunseye, Paloma I Beamer, Helena Solo-Gabriele, Alesia Ferguson","doi":"10.1038/s41370-025-00749-3","DOIUrl":"10.1038/s41370-025-00749-3","url":null,"abstract":"<p><strong>Background: </strong>Children are vulnerable to household dust exposure; however, to date, a handful of studies simultaneously report both the mass and particle size of household dust found on children's hands after natural indoor play activities.</p><p><strong>Objective: </strong>Evaluate a new approach to measure dust loading and characterize particle size on a child's hands using a Coulter Counter.</p><p><strong>Methods: </strong>The volume of particles rinsed off children's hands was measured through counting and sizing particles (using a Coulter Counter), followed by multiplying the particle volume by the density of dust collected from the home. This mass was then normalized per total hand surface area to obtain dust loading on children's hands. Results were compared by region (North Carolina, Florida, Arizona), age groups (6 months to 6 years), and social demographics (gender, race, ethnicity) for 101 children.</p><p><strong>Results: </strong>The estimated median density for household dust was 1.54 g/cm<sup>3</sup>, with an average of 1.58 g/cm<sup>3</sup> (SD = 0.43). The overall median dust loading on children's hands was 11.13 μg/cm<sup>2</sup> (per total hand surface area), with a range of 0.004-167.6 μg/cm<sup>2</sup>. No statistical difference was observed by region, age, nor social demographics (p > 0.05). The majority of particles (90%) from children's hand rinses had a diameter (D<sub>90,v</sub>) <35 μm; however, these small particles represent a fraction of the total mass. This new approach succeeded at obtaining dust loadings and particle size simultaneously from the same sample, in contrast to current methods that would have required multiple methods and sample types.</p><p><strong>Impact statement: </strong>Children are vulnerable to household dust due to their play behavior; however, to date, limited measurements are available for the mass and particle size of dust on children's hands after natural indoor play activities. We propose a new approach to facilitate dust loading measurements, while also obtaining the particle size of dust, through the usage of a Coulter Counter. Results showed that 90% of particles were <35 μm, which is four times smaller than the current guidelines threshold (150 μm) for risk assessments that utilize estimates for particles found on hands.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sub-micrometer scale synchrotron x-ray fluorescence measurements of trace elements in teeth compared with laser ablation inductively coupled plasma mass spectrometry. 亚微米尺度同步x射线荧光测量牙齿中微量元素与激光烧蚀电感耦合等离子体质谱的比较。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-29 DOI: 10.1038/s41370-025-00754-6
Aaron J Specht, Xinxin Zhang, Olga A Antipova, Abu Sayed Mohammed Sayam, Vy T Nguyen, Christian G Hoover, Tracy Punshon, Brian P Jackson, Marc G Weisskopf
{"title":"Sub-micrometer scale synchrotron x-ray fluorescence measurements of trace elements in teeth compared with laser ablation inductively coupled plasma mass spectrometry.","authors":"Aaron J Specht, Xinxin Zhang, Olga A Antipova, Abu Sayed Mohammed Sayam, Vy T Nguyen, Christian G Hoover, Tracy Punshon, Brian P Jackson, Marc G Weisskopf","doi":"10.1038/s41370-025-00754-6","DOIUrl":"https://doi.org/10.1038/s41370-025-00754-6","url":null,"abstract":"<p><strong>Background: </strong>Elemental analysis of teeth allows for exposure assessment during critical windows of development and is increasingly used to link early life exposures and health. The measurement of inorganic elements in teeth is challenging; laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is the most widely used technique.</p><p><strong>Objective: </strong>Both synchrotron x-ray fluorescence (SXRF) and LA-ICP-MS have the capability to measure elemental distributions in teeth with each having distinct advantages and disadvantages.</p><p><strong>Methods: </strong>In our study, we compared these two methods for teeth elemental quantification. SXRF was able to achieve spatial resolutions of 0.3 µm and is non-destructive while giving similar elemental quantification results to LA-ICP-MS.</p><p><strong>Results: </strong>For particular elements, SXRF can offer lower detection limits but depends on the specific beam intensity. The comparison between methods revealed less than 10% disagreement between quantification results from LA-ICP-MS and SXRF.</p><p><strong>Impact: </strong>Synchrotron x-ray fluorescence can be used to effectively quantify elemental distributions in teeth at a nanoscale resolution and is comparable to current laser ablation inductively coupled plasma mass spectrometry. Both methods offer advantages and disadvantages with LA-ICP-MS offering in-lab analyses, whereas SXRF offers much finer spatial and temporal scales and better detection capabilities. For studies focused on fine scale changes in structure, SXRF is more appropriate than LA-ICP-MS.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
marlod: an R package to model environmental exposure and biomonitoring data with repeated measurements and values below the limit of detection. marlod:一个R软件包,用于模拟环境暴露和生物监测数据,具有重复测量和低于检测极限的值。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-28 DOI: 10.1038/s41370-025-00752-8
I-Chen Chen
{"title":"marlod: an R package to model environmental exposure and biomonitoring data with repeated measurements and values below the limit of detection.","authors":"I-Chen Chen","doi":"10.1038/s41370-025-00752-8","DOIUrl":"https://doi.org/10.1038/s41370-025-00752-8","url":null,"abstract":"","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence. 产前金属暴露与早产:流行病学证据的系统回顾。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-25 DOI: 10.1038/s41370-025-00744-8
Lauren A Eaves, Evans K Lodge, Wendy R Rohin, Kyle R Roell, Tracy A Manuck, Rebecca C Fry
{"title":"Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.","authors":"Lauren A Eaves, Evans K Lodge, Wendy R Rohin, Kyle R Roell, Tracy A Manuck, Rebecca C Fry","doi":"10.1038/s41370-025-00744-8","DOIUrl":"https://doi.org/10.1038/s41370-025-00744-8","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth (PTB) is a common pregnancy complication associated with significant neonatal morbidity. Prenatal exposure to environmental chemicals, including toxic and/or essential metal(loid)s, may contribute to PTB risk.</p><p><strong>Objective: </strong>We aimed to summarize the epidemiologic evidence of the associations among levels of arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), lead (Pb), and zinc (Zn) assessed during the prenatal period and PTB or gestational age at delivery; to assess the quality of the literature and strength of evidence for an effect for each metal; and to provide recommendations for future research.</p><p><strong>Methods: </strong>We adapted the Navigation Guide methodology and followed PRISMA guidelines. We searched the MEDLINE/PubMed database for epidemiologic studies from 1995 to 2023. We used a customized risk of bias protocol and evaluated the sufficiency of evidence for an effect of each metal(loid) on PTB risk.</p><p><strong>Results: </strong>A total of 1206 studies were identified and screened. Of these, 139 were assessed for eligibility by reading the full-text, and 92 studies were ultimately included (arsenic: 40, cadmium: 30, chromium: 11, copper: 21, mercury: 27, manganese: 17, lead: 41, zinc: 18, metal(loid) mixtures: 12). We found sufficient evidence that lead increases the risk of PTB and, while the evidence was limited, suggestive evidence that cadmium and chromium increase the risk of PTB. The evidence was deemed inadequate to determine an effect for the other metal(loid)s.</p><p><strong>Significance: </strong>Future research would benefit from more precise PTB clinical phenotyping, measuring exposure early and longitudinally throughout pregnancy, using an appropriate media for metal(loid)s under study, and evaluating metal mixtures. Given the strength of evidence linking lead exposure and PTB, active and comprehensive prenatal screening for lead exposure among pregnant individuals is warranted.</p><p><strong>Impact: </strong>By summarizing 92 epidemiologic studies that investigated the associations between metal exposure and preterm birth using the rigorous Navigation Guide methodology, our review provides compelling evidence for a strong link between prenatal lead exposure and preterm birth. Additionally, it suggests potential associations between cadmium and chromium exposure and preterm birth. Given the robust nature of this evidence, there is an urgent need for prenatal screening for lead exposure during pregnancy, along with targeted interventions to reduce exposure. These actions are critical for advancing maternal and child health.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Derivation of human toxicokinetic parameters and internal threshold of toxicological concern for tenuazonic acid through a human intervention trial and hierarchical Bayesian population modeling. 通过人类干预试验和分层贝叶斯种群模型推导出替那唑酸的人体毒性动力学参数和毒理学关注的内部阈值。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-24 DOI: 10.1038/s41370-025-00746-6
Lia Visintin, En-Hsuan Lu, Hsing-Chieh Lin, Yasmine Bader, Truong Nhat Nguyen, Thanos Mouchtaris Michailidis, Sarah De Saeger, Weihsueh A Chiu, Marthe De Boevre
{"title":"Derivation of human toxicokinetic parameters and internal threshold of toxicological concern for tenuazonic acid through a human intervention trial and hierarchical Bayesian population modeling.","authors":"Lia Visintin, En-Hsuan Lu, Hsing-Chieh Lin, Yasmine Bader, Truong Nhat Nguyen, Thanos Mouchtaris Michailidis, Sarah De Saeger, Weihsueh A Chiu, Marthe De Boevre","doi":"10.1038/s41370-025-00746-6","DOIUrl":"10.1038/s41370-025-00746-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tenuazonic acid (TeA), a mycotoxin produced by Alternaria alternata, contaminates various food commodities and is known to cause acute and chronic health effects. However, the lack of human toxicokinetic (TK) data and the reliance on external exposure estimates have stalled a comprehensive risk assessment for TeA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To bridge this gap, a human TK trial and population-based TK (PopTK) modeling were applied to determine human TK parameters of TeA, and the results were applied for risk screening using population biomonitoring data and threshold of toxicological concern (TTC)-based approaches.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Ten healthy volunteers participated in the TK trial during which the volunteers ingested a bolus dose of TeA at the (external) TTC (1500 ng/kg bw). Blood, urine, and fecal samples were collected over 48 h and analyzed using UPLC-MS/MS. Concentration-time profiles were fit with a multi-compartmental PopTK model using a hierarchical Bayesian population structure. Utilizing a probabilistic framework, fitted TK parameters were used to derive internal TTC (iTTC) values for comparison to blood and urine biomonitoring data. Risk screening with data from five diverse biomonitoring cohorts was performed using Hazard Quotient (HQ) and probabilistic individual margin of exposure (IMOE) approaches.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;TeA was estimated to have a population median half-life of 1.9 [90% CI: 1.4-2.7] hours and volume of distribution of 4.4 [3.1-6.1] L/kg, with inter-individual variability geometric standard deviations of 2.4- and 1.7-fold, respectively. Probabilistic lower confidence bound iTTCs were derived of 0.5 nmol/L in blood and 2.53 nmol/kg-d urinary excretion. Risk screening HQs were mostly &gt;1 for the three blood biomonitoring cohorts and &lt; 1 for the two urinary biomonitoring cohorts; results from probabilistic IMOE calculations were qualitatively consistent.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Significance: &lt;/strong&gt;A comprehensive human TK study was performed for TeA for the first time, demonstrating the importance of integrating TK and population variability for a more comprehensive risk evaluation, particularly for interpreting biomonitoring data. The results for TeA point to the critical need for toxicity data to move beyond TTC-based risk screening.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Impact: &lt;/strong&gt;A critical gap in food safety research was addressed studying the toxicokinetics of tenuazonic acid (TeA) in humans and using these data to derive an internal threshold of toxicological concern (iTTC) for comparison to human biomonitoring data. The innovative approach-combining a human intervention trial with population-based toxicokinetic modeling-accounts for inter-individual variability and provides a more comprehensive understanding of population exposure to TeA. The resulting probabilistic iTTC and risk screening methodologies offer improved tools for interpretation of biomonitoring data. These fi","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalised estimation of exposure to ambient air pollution and application in a longitudinal cohort analysis of cognitive function in London-dwelling older adults. 暴露于环境空气污染的个性化估计和在伦敦居住的老年人认知功能纵向队列分析中的应用。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-14 DOI: 10.1038/s41370-025-00745-7
Dylan Wood, Dimitris Evangelopoulos, Nutthida Kitwiroon, Gregor Stewart, Tuan Vu, James Smith, Sean Beevers, Klea Katsouyanni
{"title":"Personalised estimation of exposure to ambient air pollution and application in a longitudinal cohort analysis of cognitive function in London-dwelling older adults.","authors":"Dylan Wood, Dimitris Evangelopoulos, Nutthida Kitwiroon, Gregor Stewart, Tuan Vu, James Smith, Sean Beevers, Klea Katsouyanni","doi":"10.1038/s41370-025-00745-7","DOIUrl":"10.1038/s41370-025-00745-7","url":null,"abstract":"<p><strong>Background: </strong>Accurate estimates of personal exposure to ambient air pollution are difficult to obtain and epidemiological studies generally rely on residence-based estimates, averaged spatially and temporally, derived from monitoring networks or models. Few epidemiological studies have compared the associated health effects of personal exposure and residence-based estimates.</p><p><strong>Objective: </strong>To evaluate the association between exposure to air pollution and cognitive function using exposure estimates taking mobility and location into account.</p><p><strong>Methods: </strong>Residence-based dispersion model estimates of ambient NO<sub>2</sub>, PM<sub>10</sub> and PM<sub>2.5</sub> were assigned to 768 London-dwelling participants of the English Longitudinal Study of Ageing. The London Hybrid Exposure Model was implemented to adjust estimates per pollutant to reflect the estimated time-activity patterns of each participant based on age and residential location. Single pollutant linear mixed-effects models were fit for both exposure assessment methods to investigate the associations between assigned pollutant concentrations and cognitive function over a follow-up period of up to 15 years.</p><p><strong>Results: </strong>Increased long-term exposures to residence-based ambient NO<sub>2</sub> (IQR: 11.10 µg/m<sup>3</sup>), PM<sub>10</sub> (2.35 µg/m<sup>3</sup>), and PM<sub>2.5</sub> (2.50 µg/m<sup>3</sup>) were associated with decreases of -0.10 [95% CI: -0.20, 0.00], -0.07 [-0.11, -0.02] and -0.14 [-0.21, -0.06], respectively, in composite memory score. Similar decreases were observed for executive function scores (-0.38 [-0.58, -0.18], -0.11 [-0.20, -0.02] and -0.14 [-0.29, 0.01], respectively). When applying personalised exposure estimates, which were substantially lower, similar decreases were observed for composite memory score per IQR, but a consistent pattern of slightly more adverse effects with executive function score was evident.</p><p><strong>Impact statement: </strong>The present study constructed a framework through which time-activity information derived from a representative sample could be applied to estimates of ambient air pollution concentrations assigned to individuals in epidemiological cohort studies, with the intention of adjusting commonly used residence-based estimates to reflect population mobility and time spent in various microenvironments. Estimates of exposure were markedly lower when incorporating time-activity, likely because people in European populations spend a large proportion of their time indoors, where their exposure to ambient air pollution may be reduced through infiltration, which is not taken into account in residence-based ambient estimates. Further work into such methods could provide insights into the efficacy of personalising exposure estimates.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classroom air quality in a randomized crossover trial with portable HEPA air cleaners. 便携式高效微粒空气净化器在教室空气质量随机交叉试验中的应用。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-11 DOI: 10.1038/s41370-025-00743-9
Shayna C Simona, Scott M Bartell, Verónica M Vieira
{"title":"Classroom air quality in a randomized crossover trial with portable HEPA air cleaners.","authors":"Shayna C Simona, Scott M Bartell, Verónica M Vieira","doi":"10.1038/s41370-025-00743-9","DOIUrl":"https://doi.org/10.1038/s41370-025-00743-9","url":null,"abstract":"<p><strong>Background: </strong>Children living in communities with lower socioeconomic status and higher minority populations are often disproportionately exposed to particulate matter (PM) compared to children living in other communities.</p><p><strong>Objective: </strong>We assessed whether adding HEPA filter air cleaners to classrooms with existing HVAC systems reduces indoor air pollution exposure.</p><p><strong>Methods: </strong>From July 2022 to June 2023, using a block randomized crossover trial of 17 Los Angeles Unified School District elementary schools, classroom PM concentrations were monitored and compared for 99 classrooms with HEPA filter air cleaners and 87 classrooms with non-HEPA filter air cleaners.</p><p><strong>Results: </strong>In HEPA classrooms, average school-year PM<sub>2.5</sub> was 39.9% lower (0.581 µg/m³; p < 0.001) and infiltration of outdoor PM<sub>2.5</sub> into classrooms was 13.8-82.4% lower than non-HEPA classrooms, depending on the school.</p><p><strong>Impact: </strong>Few studies have examined HEPA filtration in a classroom environment, and this is one of the first studies since the COVID-19 pandemic to assess PM exposure in the classroom. Using a well powered block randomized crossover trial, we showed that adding portable HEPA air cleaners to classrooms that already had HVAC systems with MERV 13 air filters resulted in lower measurable PM concentrations and less infiltration of outdoor PM<sub>2.5</sub> compared to control classrooms with non-HEPA filters. This demonstrates that further improvements in classroom air quality, especially in environmentally burdened communities, can be achieved with additional filtration.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community impacts of aviation noise: a pilot survey 航空噪音对社区的影响:一项试点调查。
IF 4.1 3区 医学
Journal of Exposure Science and Environmental Epidemiology Pub Date : 2025-01-07 DOI: 10.1038/s41370-024-00737-z
Jamie L. Banks, Becky Petrou O’Rourke
{"title":"Community impacts of aviation noise: a pilot survey","authors":"Jamie L. Banks,&nbsp;Becky Petrou O’Rourke","doi":"10.1038/s41370-024-00737-z","DOIUrl":"10.1038/s41370-024-00737-z","url":null,"abstract":"Aviation noise policy in the United States is decades old and has not kept up with the science on the adverse effects of chronic noise exposure. New aviation noise policies are needed for the 21st century, respecting the lived experience of affected communities. Existing surveys have reported adverse impacts from aviation noise but more information is needed to understand the factors that contribute to those impacts. To evaluate the impacts of current aircraft noise exposure on impacted communities and their determinants. A 10-question online community pilot survey was distributed in May 2022 to an email list of groups and individuals in aviation-impacted communities. The survey was open for two weeks. Information on geographic location, frequency of exposure, and type of aircraft exposure were collected. Seven questions focused on the type and magnitude of health impacts, perceptions, and concerns. A total of 1452 surveys were completed within the 2-week period. Respondents report experiencing loud, repetitive, low-altitude aircraft noise - day and night - causing stress and negative effects on mental and physical health. For many, “annoyance” did not adequately describe their experience. Strong, consistent exposure-response patterns for weekly flight frequency (&lt;100 to &gt;1000 flights) were found for most health impacts, perceptions, and concerns. The likelihood of adverse impacts and heightened perceptions and concerns was greatest in respondents exposed mainly to military aircraft. Current aviation noise policy is based on annoyance, and relies on a metric that exceeds safe levels and does not meaningfully convey community impact. Aviation-impacted communities are experiencing mental and physical health impacts that extend beyond annoyance. The magnitude of impact is influenced by flight frequency and aircraft type. Aviation noise policy should be updated to account for those factors and focus on reducing public health impacts and their human and economic costs. Aviation noise policy in the United States is decades old and is based solely on the concept of annoyance without sufficient regard to the harms caused to health and well-being of people living in aviation-impacted communities. Efforts to amend the policy must be informed by the scientific evidence on the adverse effects of noise and health and by metrics that properly represent the lived experiences of communities. The results of this pilot survey highlight the importance of incorporating these aspects into policy for preventing and mitigating harms caused by aviation noise, especially as the industry grows.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 1","pages":"80-90"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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