Yuhong Hu, Thomas Chavez, Sandrah P Eckel, Tingyu Yang, Xinci Chen, Mario Vigil, Nathan Pavlovic, Fred Lurmann, Deborah Lerner, Nathana Lurvey, Brendan Grubbs, Laila Al-Marayati, Claudia Toledo-Corral, Jill Johnston, Genevieve F Dunton, Shohreh F Farzan, Rima Habre, Carrie Breton, Theresa M Bastain
{"title":"交通相关空气污染和妊娠高血压疾病对产妇产后抑郁和焦虑症状的共同影响。","authors":"Yuhong Hu, Thomas Chavez, Sandrah P Eckel, Tingyu Yang, Xinci Chen, Mario Vigil, Nathan Pavlovic, Fred Lurmann, Deborah Lerner, Nathana Lurvey, Brendan Grubbs, Laila Al-Marayati, Claudia Toledo-Corral, Jill Johnston, Genevieve F Dunton, Shohreh F Farzan, Rima Habre, Carrie Breton, Theresa M Bastain","doi":"10.1038/s41370-024-00692-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Ambient air pollution has been linked to postpartum depression. However, few studies have investigated the effects of traffic-related NO<sub>x</sub> on postpartum depression and whether any pregnancy-related factors might increase susceptibility.</p><p><strong>Objectives: </strong>To evaluate the association between traffic-related NO<sub>x</sub> and postpartum depressive and anxiety symptoms, and effect modification by pregnancy-related hypertension.</p><p><strong>Methods: </strong>This study included 453 predominantly low-income Hispanic/Latina women in the MADRES cohort. Daily traffic-related NO<sub>x</sub> concentrations by road class were estimated using the California LINE-source dispersion model (CALINE4) at participants' residential locations and averaged across pregnancy. Postpartum depressive and anxiety symptoms were evaluated by a validated questionnaire (Postpartum Distress Measure, PDM) at 1, 3, 6 and 12 months postpartum. Multivariate linear regressions were performed to estimate the associations at each timepoint. Interaction terms were added to the linear models to assess effect modification by hypertensive disorders of pregnancy (HDPs). Repeated measurement analyses were conducted by using mixed effect models.</p><p><strong>Results: </strong>We found prenatal traffic-related NO<sub>x</sub> was associated with increased PDM scores. Specifically, mothers exposed to an IQR (0.22 ppb) increase in NO<sub>x</sub> from major roads had 3.78% (95% CI: 0.53-7.14%) and 5.27% (95% CI: 0.33-10.45%) significantly higher 3-month and 12-month PDM scores, respectively. Similarly, in repeated measurement analyses, higher NO<sub>x</sub> from major roads was associated with 3.06% (95% CI: 0.43-5.76%) significantly higher PDM scores across the first year postpartum. Effect modification by HDPs was observed: higher freeway/highway and total NO<sub>x</sub> among mothers with HDPs were associated with significantly higher PDM scores at 12 months postpartum compared to those without HDPs.</p><p><strong>Impact: </strong>This study shows that prenatal traffic-related air pollution was associated with postpartum depressive and anxiety symptoms. The study also found novel evidence of greater susceptibility among women with HDPs, which advances the understanding of the relationships between air pollution, maternal cardiometabolic health during pregnancy and postpartum mental health. Our study has potential implications for clinical intervention to mitigate the effects of traffic-related pollution on postpartum mental health disorders. The findings can also offer valuable insights into urban planning strategies concerning the implementation of emission control measures and the creation of green spaces.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms.\",\"authors\":\"Yuhong Hu, Thomas Chavez, Sandrah P Eckel, Tingyu Yang, Xinci Chen, Mario Vigil, Nathan Pavlovic, Fred Lurmann, Deborah Lerner, Nathana Lurvey, Brendan Grubbs, Laila Al-Marayati, Claudia Toledo-Corral, Jill Johnston, Genevieve F Dunton, Shohreh F Farzan, Rima Habre, Carrie Breton, Theresa M Bastain\",\"doi\":\"10.1038/s41370-024-00692-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Ambient air pollution has been linked to postpartum depression. However, few studies have investigated the effects of traffic-related NO<sub>x</sub> on postpartum depression and whether any pregnancy-related factors might increase susceptibility.</p><p><strong>Objectives: </strong>To evaluate the association between traffic-related NO<sub>x</sub> and postpartum depressive and anxiety symptoms, and effect modification by pregnancy-related hypertension.</p><p><strong>Methods: </strong>This study included 453 predominantly low-income Hispanic/Latina women in the MADRES cohort. Daily traffic-related NO<sub>x</sub> concentrations by road class were estimated using the California LINE-source dispersion model (CALINE4) at participants' residential locations and averaged across pregnancy. Postpartum depressive and anxiety symptoms were evaluated by a validated questionnaire (Postpartum Distress Measure, PDM) at 1, 3, 6 and 12 months postpartum. Multivariate linear regressions were performed to estimate the associations at each timepoint. Interaction terms were added to the linear models to assess effect modification by hypertensive disorders of pregnancy (HDPs). Repeated measurement analyses were conducted by using mixed effect models.</p><p><strong>Results: </strong>We found prenatal traffic-related NO<sub>x</sub> was associated with increased PDM scores. Specifically, mothers exposed to an IQR (0.22 ppb) increase in NO<sub>x</sub> from major roads had 3.78% (95% CI: 0.53-7.14%) and 5.27% (95% CI: 0.33-10.45%) significantly higher 3-month and 12-month PDM scores, respectively. Similarly, in repeated measurement analyses, higher NO<sub>x</sub> from major roads was associated with 3.06% (95% CI: 0.43-5.76%) significantly higher PDM scores across the first year postpartum. Effect modification by HDPs was observed: higher freeway/highway and total NO<sub>x</sub> among mothers with HDPs were associated with significantly higher PDM scores at 12 months postpartum compared to those without HDPs.</p><p><strong>Impact: </strong>This study shows that prenatal traffic-related air pollution was associated with postpartum depressive and anxiety symptoms. The study also found novel evidence of greater susceptibility among women with HDPs, which advances the understanding of the relationships between air pollution, maternal cardiometabolic health during pregnancy and postpartum mental health. Our study has potential implications for clinical intervention to mitigate the effects of traffic-related pollution on postpartum mental health disorders. 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Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms.
Background: Ambient air pollution has been linked to postpartum depression. However, few studies have investigated the effects of traffic-related NOx on postpartum depression and whether any pregnancy-related factors might increase susceptibility.
Objectives: To evaluate the association between traffic-related NOx and postpartum depressive and anxiety symptoms, and effect modification by pregnancy-related hypertension.
Methods: This study included 453 predominantly low-income Hispanic/Latina women in the MADRES cohort. Daily traffic-related NOx concentrations by road class were estimated using the California LINE-source dispersion model (CALINE4) at participants' residential locations and averaged across pregnancy. Postpartum depressive and anxiety symptoms were evaluated by a validated questionnaire (Postpartum Distress Measure, PDM) at 1, 3, 6 and 12 months postpartum. Multivariate linear regressions were performed to estimate the associations at each timepoint. Interaction terms were added to the linear models to assess effect modification by hypertensive disorders of pregnancy (HDPs). Repeated measurement analyses were conducted by using mixed effect models.
Results: We found prenatal traffic-related NOx was associated with increased PDM scores. Specifically, mothers exposed to an IQR (0.22 ppb) increase in NOx from major roads had 3.78% (95% CI: 0.53-7.14%) and 5.27% (95% CI: 0.33-10.45%) significantly higher 3-month and 12-month PDM scores, respectively. Similarly, in repeated measurement analyses, higher NOx from major roads was associated with 3.06% (95% CI: 0.43-5.76%) significantly higher PDM scores across the first year postpartum. Effect modification by HDPs was observed: higher freeway/highway and total NOx among mothers with HDPs were associated with significantly higher PDM scores at 12 months postpartum compared to those without HDPs.
Impact: This study shows that prenatal traffic-related air pollution was associated with postpartum depressive and anxiety symptoms. The study also found novel evidence of greater susceptibility among women with HDPs, which advances the understanding of the relationships between air pollution, maternal cardiometabolic health during pregnancy and postpartum mental health. Our study has potential implications for clinical intervention to mitigate the effects of traffic-related pollution on postpartum mental health disorders. The findings can also offer valuable insights into urban planning strategies concerning the implementation of emission control measures and the creation of green spaces.
期刊介绍：
Journal of Exposure Science and Environmental Epidemiology (JESEE) aims to be the premier and authoritative source of information on advances in exposure science for professionals in a wide range of environmental and public health disciplines.
JESEE publishes original peer-reviewed research presenting significant advances in exposure science and exposure analysis, including development and application of the latest technologies for measuring exposures, and innovative computational approaches for translating novel data streams to characterize and predict exposures. The types of papers published in the research section of JESEE are original research articles, translation studies, and correspondence. Reported results should further understanding of the relationship between environmental exposure and human health, describe evaluated novel exposure science tools, or demonstrate potential of exposure science to enable decisions and actions that promote and protect human health.
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