Journal of Exposure Science and Environmental Epidemiology最新文献

{"title":"Personalised estimation of exposure to ambient air pollution and application in a longitudinal cohort analysis of cognitive function in London-dwelling older adults.","authors":"Dylan Wood, Dimitris Evangelopoulos, Nutthida Kitwiroon, Gregor Stewart, Tuan Vu, James Smith, Sean Beevers, Klea Katsouyanni","doi":"10.1038/s41370-025-00745-7","DOIUrl":"https://doi.org/10.1038/s41370-025-00745-7","url":null,"abstract":"<p><strong>Background: </strong>Accurate estimates of personal exposure to ambient air pollution are difficult to obtain and epidemiological studies generally rely on residence-based estimates, averaged spatially and temporally, derived from monitoring networks or models. Few epidemiological studies have compared the associated health effects of personal exposure and residence-based estimates.</p><p><strong>Objective: </strong>To evaluate the association between exposure to air pollution and cognitive function using exposure estimates taking mobility and location into account.</p><p><strong>Methods: </strong>Residence-based dispersion model estimates of ambient NO₂, PM₁₀ and PM_2.5 were assigned to 768 London-dwelling participants of the English Longitudinal Study of Ageing. The London Hybrid Exposure Model was implemented to adjust estimates per pollutant to reflect the estimated time-activity patterns of each participant based on age and residential location. Single pollutant linear mixed-effects models were fit for both exposure assessment methods to investigate the associations between assigned pollutant concentrations and cognitive function over a follow-up period of up to 15 years.</p><p><strong>Results: </strong>Increased long-term exposures to residence-based ambient NO₂ (IQR: 11.10 µg/m³), PM₁₀ (2.35 µg/m³), and PM_2.5 (2.50 µg/m³) were associated with decreases of -0.10 [95% CI: -0.20, 0.00], -0.07 [-0.11, -0.02] and -0.14 [-0.21, -0.06], respectively, in composite memory score. Similar decreases were observed for executive function scores (-0.38 [-0.58, -0.18], -0.11 [-0.20, -0.02] and -0.14 [-0.29, 0.01], respectively). When applying personalised exposure estimates, which were substantially lower, similar decreases were observed for composite memory score per IQR, but a consistent pattern of slightly more adverse effects with executive function score was evident.</p><p><strong>Impact statement: </strong>The present study constructed a framework through which time-activity information derived from a representative sample could be applied to estimates of ambient air pollution concentrations assigned to individuals in epidemiological cohort studies, with the intention of adjusting commonly used residence-based estimates to reflect population mobility and time spent in various microenvironments. Estimates of exposure were markedly lower when incorporating time-activity, likely because people in European populations spend a large proportion of their time indoors, where their exposure to ambient air pollution may be reduced through infiltration, which is not taken into account in residence-based ambient estimates. Further work into such methods could provide insights into the efficacy of personalising exposure estimates.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classroom air quality in a randomized crossover trial with portable HEPA air cleaners.","authors":"Shayna C Simona, Scott M Bartell, Verónica M Vieira","doi":"10.1038/s41370-025-00743-9","DOIUrl":"https://doi.org/10.1038/s41370-025-00743-9","url":null,"abstract":"<p><strong>Background: </strong>Children living in communities with lower socioeconomic status and higher minority populations are often disproportionately exposed to particulate matter (PM) compared to children living in other communities.</p><p><strong>Objective: </strong>We assessed whether adding HEPA filter air cleaners to classrooms with existing HVAC systems reduces indoor air pollution exposure.</p><p><strong>Methods: </strong>From July 2022 to June 2023, using a block randomized crossover trial of 17 Los Angeles Unified School District elementary schools, classroom PM concentrations were monitored and compared for 99 classrooms with HEPA filter air cleaners and 87 classrooms with non-HEPA filter air cleaners.</p><p><strong>Results: </strong>In HEPA classrooms, average school-year PM_2.5 was 39.9% lower (0.581 µg/m³; p < 0.001) and infiltration of outdoor PM_2.5 into classrooms was 13.8-82.4% lower than non-HEPA classrooms, depending on the school.</p><p><strong>Impact: </strong>Few studies have examined HEPA filtration in a classroom environment, and this is one of the first studies since the COVID-19 pandemic to assess PM exposure in the classroom. Using a well powered block randomized crossover trial, we showed that adding portable HEPA air cleaners to classrooms that already had HVAC systems with MERV 13 air filters resulted in lower measurable PM concentrations and less infiltration of outdoor PM_2.5 compared to control classrooms with non-HEPA filters. This demonstrates that further improvements in classroom air quality, especially in environmentally burdened communities, can be achieved with additional filtration.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States.","authors":"Shiwen Li, Paulina Oliva, Lu Zhang, Jesse A Goodrich, Rob McConnell, David V Conti, Lida Chatzi, Max Aung","doi":"10.1038/s41370-024-00742-2","DOIUrl":"https://doi.org/10.1038/s41370-024-00742-2","url":null,"abstract":"<p><strong>Background: </strong>Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water and cancers can help inform biomonitoring and prevention efforts.</p><p><strong>Objective: </strong>To screen for incident cancer (2016-2021) and assess associations with PFAS contamination in drinking water in the US.</p><p><strong>Methods: </strong>We obtained county-level age-adjusted cancer incidence (2016-2021) from the Surveillance, Epidemiology, and End Results (SEER) Program. Data on PFAS levels in public drinking water systems were obtained from the Third (UCMR3; 2013-2015) and Fifth (UCMR5; 2023-2024) Unregulated Contaminant Monitoring Rule. UCMR3 measured PFOS, PFOA, PFNA, PFHxS, PFHpA, and PFBS. UCMR5 expanded measurements to include PFBA, PFHxA, PFPeA, and PFPeS. We created indicators of PFAS detection and, for UCMR5, concentrations above Maximum Contaminant Levels (MCLs). MCLs for PFOA and PFOS are 4 ng/L, and for PFNA and PFHxS are 10 ng/L. We used Poisson regression models to assess associations between PFAS detection or MCL violation and cancer incidence, adjusting for potential confounders. We estimated the number of attributable cancer cases.</p><p><strong>Results: </strong>PFAS in drinking water was associated with increased cancer incidence in the digestive, endocrine, oral cavity/pharynx, and respiratory systems. Incidence rate ratios (IRRs) ranged from 1.02 to 1.33. The strongest association was observed between PFBS and oral cavity/pharynx cancers (IRR: 1.33 [1.04, 1.71]). Among males, PFAS was associated with cancers in the urinary, brain, leukemia, and soft tissues. Among females, PFAS was associated with cancers in the thyroid, oral cavity/pharynx, and soft tissue. PFAS in drinking water is estimated to contribute to 4626 [95% CI: 1,377, 8046] incident cancer cases per year based on UCMR3 data and 6864 [95% CI: 991, 12,804] based on UCMR5.</p><p><strong>Impact statement: </strong>The ecological study examined the associations between PFAS in drinking water measured in two waves (2013-2015 and 2023-2024) and cancer incidence between 2016 and 2021. We found that PFAS in drinking water was associated with cancers in the organ system including the oral cavity/pharynx, lung, digestive system, brain, urinary system, soft tissue, and thyroid. Some cancers have not been widely studied for their associations with PFAS. We also observed sex differences in the associations between PFAS and cancer risks. This is the first ecological study that examined PFAS exposure in drinking water and various cancer risks.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community impacts of aviation noise: a pilot survey.","authors":"Jamie L Banks, Becky Petrou O'Rourke","doi":"10.1038/s41370-024-00737-z","DOIUrl":"https://doi.org/10.1038/s41370-024-00737-z","url":null,"abstract":"<p><strong>Background: </strong>Aviation noise policy in the United States is decades old and has not kept up with the science on the adverse effects of chronic noise exposure. New aviation noise policies are needed for the 21^st century, respecting the lived experience of affected communities. Existing surveys have reported adverse impacts from aviation noise but more information is needed to understand the factors that contribute to those impacts.</p><p><strong>Objective: </strong>To evaluate the impacts of current aircraft noise exposure on impacted communities and their determinants.</p><p><strong>Methods: </strong>A 10-question online community pilot survey was distributed in May 2022 to an email list of groups and individuals in aviation-impacted communities. The survey was open for two weeks. Information on geographic location, frequency of exposure, and type of aircraft exposure were collected. Seven questions focused on the type and magnitude of health impacts, perceptions, and concerns.</p><p><strong>Results: </strong>A total of 1452 surveys were completed within the 2-week period. Respondents report experiencing loud, repetitive, low-altitude aircraft noise - day and night - causing stress and negative effects on mental and physical health. For many, \"annoyance\" did not adequately describe their experience. Strong, consistent exposure-response patterns for weekly flight frequency (<100 to >1000 flights) were found for most health impacts, perceptions, and concerns. The likelihood of adverse impacts and heightened perceptions and concerns was greatest in respondents exposed mainly to military aircraft.</p><p><strong>Significance: </strong>Current aviation noise policy is based on annoyance, and relies on a metric that exceeds safe levels and does not meaningfully convey community impact. Aviation-impacted communities are experiencing mental and physical health impacts that extend beyond annoyance. The magnitude of impact is influenced by flight frequency and aircraft type. Aviation noise policy should be updated to account for those factors and focus on reducing public health impacts and their human and economic costs.</p><p><strong>Impact statement: </strong>Aviation noise policy in the United States is decades old and is based solely on the concept of annoyance without sufficient regard to the harms caused to health and well-being of people living in aviation-impacted communities. Efforts to amend the policy must be informed by the scientific evidence on the adverse effects of noise and health and by metrics that properly represent the lived experiences of communities. The results of this pilot survey highlight the importance of incorporating these aspects into policy for preventing and mitigating harms caused by aviation noise, especially as the industry grows.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex specificity in associations between exposure to a mixture of per and poly-fluoroalkyl substances and anxiety among US adults.","authors":"Xiaoguo Hua, Rui Hu, Cai Chen, Jiangjie Sun, Xiqiu Feng, Xiujun Zhang","doi":"10.1038/s41370-024-00741-3","DOIUrl":"https://doi.org/10.1038/s41370-024-00741-3","url":null,"abstract":"<p><strong>Background: </strong>Exposure to per and poly-fluoroalkyl substances (PFAS) is suggested to interfere with the central nervous system that may affect mental health. Studies on the relationships between exposure to PFAS mixtures and anxiety in humans are rare. This study aimed to evaluate the associations between single and combined exposure to PFAS and anxiety among adults.</p><p><strong>Methods: </strong>Data were extracted from the National Health and Nutrition Examination Survey (NHANES, 2007-2012). Six serum PFAS concentrations were accessed including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), PFOS (perfluorooctanesulfonic acid), PFHxS (perfluorohexane sulfonate), PFDA (perfluorodecanoic acid), Me-PFOSA-AcOH (2-(N-methylperfluorooctanesulfonamide) acetic acid). The anxiety state was defined through the questionnaire responses of the participants. Weighted logistics regression was used to calculate their odds ratio (OR) and corresponding confidence interval (95% CI) that assessed the relationship between PFAS exposure and anxiety. Moreover, Two different statistical methods including quantile-based g-computation (Qgcomp), and Bayesian kernel machine regression (BKMR) were employed to investigate the overall effects of PFAS mixtures on anxiety.</p><p><strong>Results: </strong>The effects of specific PFAS exposure on anxiety varied by sex. In male participants, one-unit increase in PFDA (OR = 0.62; 95%CI: 0.44, 0.88), PFOA (OR = 0.60; 95%CI: 0.41, 0.87), PFNA (OR = 0.68; 95%CI: 0.46, 0.96) concentrations were inversely linked to anxiety. In female participants, a one-unit increase in PFOA (OR = 1.50; 95%CI: 1.05, 2.14) concentration was associated with anxiety. Analysis of Qgcomp demonstrated that PFAS mixtures were negatively associated with anxiety in males (OR = 0.85; 95%CI: 0.74, 0.99), and were positively associated with anxiety in females(OR = 1.16; 95%CI: 1.01, 1.33). Analysis of BKMR suggested that PFAS mixtures were negatively associated with anxiety in the males, while its associations with anxiety were positive in the females.</p><p><strong>Impact: </strong>Although a growing number of studies have focused on the relationship between PFAS and anxiety, most have been performed based on animal observations rather than human populations, and the combined effects of PFAS mixtures on anxiety have not been evaluated. To address these gaps, this study first explored the associations between individual PFAS and PFAS mixture exposures and anxiety among US adults. Using data from the National Health and Nutrition Examination Survey, we demonstrated that co-exposure to a mixture of PFAS was negatively associated with anxiety in males, and its association was contrary in females.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile hydrocarbon exposures and immune-related illnesses among Deepwater Horizon oil spill workers.","authors":"Opal P Patel, Kaitlyn G Lawrence, Christine G Parks, Patricia A Stewart, Mark R Stenzel, Caroline P Groth, Gurumurthy Ramachandran, Sudipto Banerjee, Tran B Huynh, Braxton Jackson, Dale P Sandler, Lawrence S Engel","doi":"10.1038/s41370-024-00738-y","DOIUrl":"https://doi.org/10.1038/s41370-024-00738-y","url":null,"abstract":"<p><strong>Background: </strong>Despite evidence from experimental studies linking some petroleum hydrocarbons to markers of immune suppression, limited epidemiologic research exists on this topic.</p><p><strong>Objective: </strong>The aim of this cross-sectional study was to examine associations of oil spill related chemicals (benzene, toluene, ethylbenzene, xylene, and n-hexane (BTEX-H)) and total hydrocarbons (THC) with immune-related illnesses as indicators of potential immune suppression.</p><p><strong>Methods: </strong>Subjects comprised 8601 Deepwater Horizon (DWH) oil spill clean-up and response workers who participated in a home visit (1-3 years after the DWH spill) in the Gulf Long-term Follow-up (GuLF) Study. Cumulative exposures to THC and individual BTEX-H constituents during the oil spill clean-up were estimated using a job-exposure matrix linking air measurement data to detailed participant work histories. Study outcomes included post-spill occurrence and/or frequency of illnesses ascertained at the home visit, including colds, flu, cold sores, pneumonia, and shingles. Frequent cold and frequent flu were defined as ≥4 colds and ≥2 episodes of flu since the spill, respectively. We examined an aggregate outcome of frequent colds, any flu, cold sores, or pneumonia since the spill. In single pollutant models, we used multivariable log-binomial regression to estimate prevalence ratios (PR) and 95% confidence intervals (CI) for associations between quartiles of THC and BTEX-H exposures with each outcome. We used quantile g-computation to estimate the joint effect of the BTEX-H mixture.</p><p><strong>Results: </strong>We observed positive associations of increasing quartiles of THC and BTEX-H with all outcomes except shingles, with evidence of an exposure-response for most outcomes. Strongest associations were observed for frequent flu (range of PR: 1.41-1.67). The BTEX-H mixture was associated with small to modest elevations in PRs for most outcomes.</p><p><strong>Impact statement: </strong>This study is the first to our knowledge to demonstrate an association between oil spill BTEX-H exposures and multiple immune-related illnesses as measures of potential immune suppression. Increasing oil spill-related volatile hydrocarbon exposures may increase the risk of multiple immune-related illnesses, especially frequent cold and frequent flu. Future research on this topic using more robust measures of immune function would advance existing evidence on this relationship.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental costs of noise pollution-is history rhyming again?","authors":"Peter M Bingham","doi":"10.1038/s41370-024-00725-3","DOIUrl":"https://doi.org/10.1038/s41370-024-00725-3","url":null,"abstract":"","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study.","authors":"Marlene Stratmann, Fatih Özel, Maria Marinopoulou, Christian Lindh, Hannu Kiviranta, Chris Gennings, Carl-Gustaf Bornehag","doi":"10.1038/s41370-024-00739-x","DOIUrl":"https://doi.org/10.1038/s41370-024-00739-x","url":null,"abstract":"<p><strong>Background: </strong>Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture.</p><p><strong>Objective: </strong>The objective is to determine associations between prenatal exposure to EDCs and behavioural difficulties. Furthermore, we investigated sex-specific associations and determined chemicals of concern in significant regressions.</p><p><strong>Methods: </strong>Associations between prenatal exposure to EDCs (both as single compounds and their mixtures) and behavioural outcomes using the Strengths and Difficulties Questionnaire (SDQ) were estimated in 607 mother-child pairs in the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy (SELMA) study. Levels for chemical compounds were measured in either urine or serum (median of 10 weeks of gestation). Associations were estimated for the total SDQ score (quasipoisson regression) and a 90th percentile cut-off (logistic regression). Exposure for EDC mixtures (phenols, phthalates, PFAS and persistent chlorinated) was studied using weighted quantile sum (WQS) regression with deciles and with and without repeated holdout validation techniques. The models were adjusted for selected covariates.</p><p><strong>Results: </strong>The odds for behavioural difficulties increased in girls with higher chemical exposures (OR 1.77, 95% CI 1.67, 1.87) using the full sample and borderline for the validation set (OR 1.31, 95% CI 0.93, 1.85) with 94/100 positive betas in the 100 repeated holdout validations. Chemicals of concern for girls are mostly short-lived chemicals and more specifically plasticizers. No pattern of significant associations was detected for boys.</p><p><strong>Significance: </strong>There is an indication of increased behavioural difficulties for girls in the SELMA population with higher exposure to mixtures of EDCs. Using the repeated holdout validation techniques, the inference is more stable, reproducible and generalisable. Prenatal exposure to mixtures of environmental chemicals should be considered when assessing the safety of chemicals.</p><p><strong>Impact: </strong>Growing evidence points towards a \"mixture effect\" where different environmental chemicals might act jointly where individual compounds may be below a level of concern, but the combination may have an effect on human health. We are constantly exposed to a complicated mixture pattern that is individual for every person as this mixture depends on personal choices of lifestyle, diet and housing to name a few. Our study suggests that prenatal exposure to EDCs might adversely affect the behaviour of children and especially girls. Hence, risk assessment needs to improve and sex-specific mechanisms should be included in assessments.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noise causes cardiovascular disease: it's time to act.","authors":"Thomas Münzel, Andreas Daiber, Nicole Engelmann, Martin Röösli, Marin Kuntic, Jamie L Banks","doi":"10.1038/s41370-024-00732-4","DOIUrl":"10.1038/s41370-024-00732-4","url":null,"abstract":"<p><strong>Background: </strong>Chronic transportation noise is an environmental stressor affecting a substantial portion of the population. The World Health Organization (WHO) and various studies have established associations between transportation noise and cardiovascular disease (CVD), such as myocardial infarction, stroke, heart failure, and arrhythmia. The WHO Environmental Noise Guidelines and recent reviews confirm a heightened risk of cardiovascular incidents with increasing transportation noise levels.</p><p><strong>Objective: </strong>We present a narrative review of the evidence from epidemiologic studies and translation studies on the adverse cardiovascular effects of transportation noise.</p><p><strong>Methods: </strong>We describe the results of a recent Umbrella+ review that combines the evidence used in the 2018 WHO Environmental Noise Guidelines with more recent (post-2015) high-quality systematic reviews of original studies. High-quality systematic reviews were included based on the quality of literature search, risk of bias assessment, and meta-analysis methodology using AMSTAR 2.</p><p><strong>Results: </strong>Epidemiologic studies show that exposure to high levels of road traffic noise for several years lead to numerous adverse health outcomes, including premature deaths, ischemic heart disease (IHD), chronic sleep disturbances, and increased annoyance. Mechanistically, noise exposure triggers oxidative stress, inflammation, endothelial dysfunction, and circadian rhythm disruptions. These processes involve the activation of NADPH oxidase, mitochondrial dysfunction, and nitric oxide synthase uncoupling, leading to vascular and cardiac damage. Studies indicate that chronic noise exposure does not result in habituation, and susceptible individuals, such as those with pre-existing CVD, are particularly vulnerable.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical exposomics in biobanked plasma samples and associations with breast cancer risk factors.","authors":"Jessica Edlund, Kalliroi Sdougkou, Stefano Papazian, Wendy Yi-Ying Wu, Jonathan W Martin, Sophia Harlid","doi":"10.1038/s41370-024-00736-0","DOIUrl":"https://doi.org/10.1038/s41370-024-00736-0","url":null,"abstract":"<p><strong>Background: </strong>The chemical exposome includes exposure to numerous environmental and endogenous molecules, many of which have been linked to reproductive outcomes due to their endocrine-disrupting properties. As several breast cancer risk factors, including age and parity, are related to reproduction, it is imperative to investigate the interplay between such factors and the chemical exposome prior to conducting large scale exposome-based breast cancer studies.</p><p><strong>Objective: </strong>This pilot study aimed to provide an overview of the chemical exposome in plasma samples from healthy women and identify associations between environmental exposures and three risk factors for breast cancer: age, parity, and age at menarche.</p><p><strong>Material and methods: </strong>Plasma samples (n = 161), were selected based on reproductive history from 100 women participating in the Northern Sweden Health and Disease Study, between 1987 and 2006. Samples were analyzed by liquid chromatography high-resolution mass spectrometry (LC-HRMS) for 77 priority target analytes including contaminants and hormones, with simultaneous untargeted profiling of the chemical exposome and metabolome. Linear mixed effects models were applied to test associations between risk factors and chemical levels.</p><p><strong>Results: </strong>Fifty-five target analytes were detected in at least one individual and over 94,000 untargeted features were detected across all samples. Among untargeted features, 430 could be annotated and were broadly classified as environmental (246), endogenous (167) or ambiguous (17). Applying mixed effect models to features detected in at least 70% of the samples (16,778), we found seven targeted analytes (including caffeine and various per- and poly-fluoroalkyl substances) and 38 untargeted features, positively associated with age. The directionality of these associations reversed for parity, decreasing with increasing births. Seven separate targeted analytes were associated with age at menarche.</p><p><strong>Significance: </strong>This study demonstrates how a comprehensive chemical exposome approach can be used to inform future research prioritization regarding associations between known and unknown substances, reproduction, and breast cancer risk.</p><p><strong>Impact statement: </strong>This study illustrates how chemical exposomics of long-term stored blood samples offers valuable insights to discover chemical exposures and their potential links to disease in humans, particularly those related to reproduction and breast cancer risk factors.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}